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https://www.readbyqxmd.com/read/27905056/principal-covariates-clusterwise-regression-pccr-accounting-for-multicollinearity-and-population-heterogeneity-in-hierarchically-organized-data
#1
Tom Frans Wilderjans, Eva Vande Gaer, Henk A L Kiers, Iven Van Mechelen, Eva Ceulemans
In the behavioral sciences, many research questions pertain to a regression problem in that one wants to predict a criterion on the basis of a number of predictors. Although in many cases, ordinary least squares regression will suffice, sometimes the prediction problem is more challenging, for three reasons: first, multiple highly collinear predictors can be available, making it difficult to grasp their mutual relations as well as their relations to the criterion. In that case, it may be very useful to reduce the predictors to a few summary variables, on which one regresses the criterion and which at the same time yields insight into the predictor structure...
November 30, 2016: Psychometrika
https://www.readbyqxmd.com/read/27899505/an-interview-with-david-mcclay
#2
Aidan Maartens
David McClay is the Arthur S. Pearse Professor of Biology at Trinity College of Arts and Sciences, Duke University, North Carolina. His lab works on the transcriptional control of morphogenesis in the sea urchin embryo. We caught up with David at the 2016 Society for Developmental Biology - International Society of Differentiation joint meeting in Boston, where he received the Lifetime Achievement Award.
December 1, 2016: Development
https://www.readbyqxmd.com/read/27885317/poetry-and-neuroscience-an-interdisciplinary-conversation
#3
James Wilkes, Sophie K Scott
Dialogues and collaborations between scientists and non-scientists are now widely understood as important elements of scientific research and public engagement with science. In recognition of this, the authors, a neuroscientist and a poet, use a dialogical approach to extend questions and ideas first shared during a lab-based poetry residency. They recorded a conversation and then expanded it into an essayistic form, allowing divergent disciplinary understandings and uses of experiment, noise, voice and emotion to be articulated, shared and questioned...
2016: Configurations
https://www.readbyqxmd.com/read/27869519/a-post-planktonic-era-of-in-vitro-infectious-models-issues-and-changes-addressed-by-a-clinically-relevant-wound-like-media
#4
Urvish Trivedi, Jonas S Madsen, Kendra P Rumbaugh, Randall D Wolcott, Mette Burmølle, Søren J Sørensen
Medical science is pitted against an ever-increasing rise in antibiotic tolerant microorganisms. Concurrently, during the past decade, biofilms have garnered much attention within research and clinical practice. Although the significance of clinical biofilms is becoming very apparent, current methods for diagnostics and direction of therapy plans in many hospitals do not reflect this knowledge; with many of the present tools proving to be inadequate for accurately mimicking the biofilm phenomenon. Based on current findings, we address some of the fundamental issues overlooked by clinical labs: the paradigm shifts that need to occur in assessing chronic wounds; better simulation of physiological conditions in vitro; and the importance of incorporating polymicrobial populations into biofilm models...
November 21, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27856549/investigating-the-role-of-an-inquiry-based-biology-lab-course-on-student-attitudes-and-views-toward-science
#5
Erica Jeffery, Kathy Nomme, Thomas Deane, Carol Pollock, Gülnur Birol
Students' academic experiences can influence their conceptualization of science. In contrast experts hold particular beliefs, perceptions, opinions, and attitudes about science that are often absent in first-year undergraduate students. Shifts toward more expert-like attitudes and views have been linked to improved student engagement, critical-thinking ability, conceptual understanding, and academic performance. In this study, we investigate shifts in attitudes and views toward science by students in four biology classes with differences in student enrollment, academic support, and instruction...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27852827/cell-scientist-to-watch-sabine-petry
#6
(no author information available yet)
Originally from Germany, Sabine Petry received her Diploma (MSc) from Goethe University in Frankfurt and undertook her Master's thesis at the Max Planck Institute of Biophysics. She then moved to the UK to pursue a PhD under the supervision of Venki Ramakrishnan at the MRC Laboratory of Molecular Biology in Cambridge. In 2008, Sabine started her postdoctoral work in the laboratory of Ron Vale at the University of California, San Francisco as an EMBO fellow and then an HHMI postdoctoral fellow of the Life Science Research Foundation...
November 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27848190/towards-a-systematic-screening-tool-for-quality-assurance-and-semiautomatic-fraud-detection-for-images-in-the-life-sciences
#7
Lars Koppers, Holger Wormer, Katja Ickstadt
The quality and authenticity of images is essential for data presentation, especially in the life sciences. Questionable images may often be a first indicator for questionable results, too. Therefore, a tool that uses mathematical methods to detect suspicious images in large image archives can be a helpful instrument to improve quality assurance in publications. As a first step towards a systematic screening tool, especially for journal editors and other staff members who are responsible for quality assurance, such as laboratory supervisors, we propose a basic classification of image manipulation...
November 15, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27844423/introduction-to-optical-tweezers
#8
Matthias D Koch, Joshua W Shaevitz
Thirty years after their invention by Arthur Ashkin and colleagues at Bell Labs in 1986 [1], optical tweezers (or traps) have become a versatile tool to address numerous biological problems. Put simply, an optical trap is a highly focused laser beam that is capable of holding and applying forces to micron-sized dielectric objects. However, their development over the last few decades has converted these tools from boutique instruments into highly versatile instruments of molecular biophysics. This introductory chapter intends to give a brief overview of the field, highlight some important scientific achievements, and demonstrate why optical traps have become a powerful tool in the biological sciences...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27830662/controlling-placement-of-nonspherical-boomerang-colloids-in-nematic-cells-with-photopatterned-director
#9
Chenhui Peng, Taras Turiv, Rui Zhang, Yubing Guo, Sergij V Shiyanovskii, Qi-Huo Wei, Juan de Pablo, Oleg D Lavrentovich
Placing colloidal particles in predesigned sites represents a major challenge of the current state-of-the-art colloidal science. Nematic liquid crystals with spatially varying director patterns represent a promising approach to achieve a well-controlled placement of colloidal particles thanks to the elastic forces between the particles and the surrounding landscape of molecular orientation. Here we demonstrate how the spatially varying director field can be used to control placement of non-spherical particles of boomerang shape...
November 10, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27830064/evaluating-the-educational-environment-of-an-international-animal-model-based-wet-lab-course-for-undergraduate-students
#10
Michail Ch Sideris, Apostolos E Papalois, Thanos Athanasiou, Ioannis Dimitropoulos, Korina Theodoraki, Francois Sousa Dos Santos, Georgios Paparoidamis, Nikolaos Staikoglou, Dimitrios Pissas, Peter C Whitfield, Alexandros Rampotas, Savvas Papagrigoriadis, Vassilios Papalois, Georgios Zografos, Georgios Tsoulfas
BACKGROUND: Essential Skills in the management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course aimed at the undergraduate level. ESMSC combines interactive basic science workshops and case-based learning, with basic surgical training modules (BST) on Ex Vivo and In Vivo swine model. In Vivo Dissections include more advanced modules i.e. Abdominal Anatomy Dissections and Cardiac Transplant. AIM: To evaluate the educational environment of a novel course, as well as to compare Medical students' perceptions across various groups...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27812943/gene-category-analysis
#11
Sebastian Bauer
Gene-category analysis is one important knowledge integration approach in biomedical sciences that combines knowledge bases such as Gene Ontology with lists of genes or their products, which are often the result of high-throughput experiments, gained from either wet-lab or synthetic experiments. In this chapter, we will motivate this class of analyses and describe an often used variant that is based on Fisher's exact test. We show that this approach has some problems in the context of Gene Ontology of which users should be aware...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27809995/organizing-brain-science-on-an-international-scale
#12
(no author information available yet)
Examples from the last decade of neuroscience research point to an increase in international collaborations, big consortia, global data gathering, and the development of atlases and databases. How might global initiatives coordinate conceptual breakthroughs and promote discoveries without taking away from the freedom of individual labs? Scientists from around the world lent their voices to the discussion of how to address the organizational challenges of these large-scale initiatives.
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27809993/global-collaboration-learning-from-other-fields
#13
(no author information available yet)
Neuroscience research is becoming increasingly more collaborative and interdisciplinary with partnerships between industry and academia and insights from fields beyond neuroscience. In the age of institutional initiatives and multi-investigator collaborations, scientists from around the world shared their perspectives on the effectiveness of large-scale collaborations versus single-lab, hypothesis-driven science.
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27803054/an-interview-with-paola-arlotta
#14
Catarina Vicente
Paola Arlotta is a neurodevelopmental biologist based at the Harvard Department of Stem Cell and Regenerative Biology in Boston, MA, USA. Her lab studies the birth, differentiation and assembly of neuronal circuits in the cerebral cortex with the aim of developing novel therapies for degenerative and neuropsychiatric diseases. Paola has recently become an editor for Development, and we asked her about her research and career, and her recent efforts to support women in science.
November 1, 2016: Development
https://www.readbyqxmd.com/read/27799494/the-need-to-connect-on-the-cell-biology-of-synapses-behaviors-and-networks-in-science
#15
Daniel A Colón-Ramos
My laboratory is interested in the cell biology of the synapse. Synapses, which are points of cellular communication between neurons, were first described by Santiago Ramón y Cajal as "protoplasmic kisses that appear to constitute the final ecstasy of an epic love story." Who would not want to work on that?! My lab examines the biological mechanisms neurons use to find and connect to each other. How are synapses formed during development, maintained during growth, and modified during learning? In this essay, I reflect about my scientific journey to the synapse, the cell biological one, but also a metaphorical synapse-my role as a point of contact between the production of knowledge and its dissemination...
November 1, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27754182/db-03-2-renal-sympathetic-denervation-is-still-a-viable-option-for-treating-resistant-hypertension-con
#16
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27727246/data-from-a-pre-publication-independent-replication-initiative-examining-ten-moral-judgement-effects
#17
Warren Tierney, Martin Schweinsberg, Jennifer Jordan, Deanna M Kennedy, Israr Qureshi, S Amy Sommer, Nico Thornley, Nikhil Madan, Michelangelo Vianello, Eli Awtrey, Luke Lei Zhu, Daniel Diermeier, Justin E Heinze, Malavika Srinivasan, David Tannenbaum, Eliza Bivolaru, Jason Dana, Clintin P Davis-Stober, Christilene du Plessis, Quentin F Gronau, Andrew C Hafenbrack, Eko Yi Liao, Alexander Ly, Maarten Marsman, Toshio Murase, Michael Schaerer, Christina M Tworek, Eric-Jan Wagenmakers, Lynn Wong, Tabitha Anderson, Christopher W Bauman, Wendy L Bedwell, Victoria Brescoll, Andrew Canavan, Jesse J Chandler, Erik Cheries, Sapna Cheryan, Felix Cheung, Andrei Cimpian, Mark A Clark, Diana Cordon, Fiery Cushman, Peter H Ditto, Alice Amell, Sarah E Frick, Monica Gamez-Djokic, Rebecca Hofstein Grady, Jesse Graham, Jun Gu, Adam Hahn, Brittany E Hanson, Nicole J Hartwich, Kristie Hein, Yoel Inbar, Lily Jiang, Tehlyr Kellogg, Nicole Legate, Timo P Luoma, Heidi Maibeucher, Peter Meindl, Jennifer Miles, Alexandra Mislin, Daniel C Molden, Matt Motyl, George Newman, Hoai Huong Ngo, Harvey Packham, P Scott Ramsay, Jennifer L Ray, Aaron M Sackett, Anne-Laure Sellier, Tatiana Sokolova, Walter Sowden, Daniel Storage, Xiaomin Sun, Jay J Van Bavel, Anthony N Washburn, Cong Wei, Erik Wetter, Carlos T Wilson, Sophie-Charlotte Darroux, Eric Luis Uhlmann
We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27725004/lab-girl-hope-jahren-2016-alfred-a-knopf-290-pages-isbn-978-0-349-00619-2man-of-science-man-of-god-gregor-mendel-discovering-the-gene-for-his-150th-anniversary-david-j-galton-timaeus-press-at-wolfson-241-pages-isbn-978-1-326-25936-5
#18
Dorret I Boomsma
No abstract text is available yet for this article.
December 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27714185/self-propelled-autonomous-nanomotors-meet-microfluidics
#19
Bahareh Kherzi, Martin Pumera
Self-propelled autonomous nano/micromotors are in the forefront of current materials science and technology research. These small machines convert chemical energy from the environment into propulsion, and they can move autonomously in the environment and are capable of chemotaxis or magnetotaxis. They can be used for drug delivery, microsurgeries or environmental remediation. It is of immense interest from a future biomedical application point of view to understand the motion of the nano/micromotors in microfluidic channels...
October 14, 2016: Nanoscale
https://www.readbyqxmd.com/read/27714164/effect-of-temperature-on-the-viscoelastic-properties-of-nano-confined-liquid-mixtures
#20
Kislon Voïtchovsky
The behaviour of fluids confined in nanoscale gaps plays a central role in molecular science and nanofluidics, with applications ranging from biological function to multiscale printing, osmosis and filtration, lab-on-chip technology and friction reduction. Here atomic force microscopy is used to shear five different mixtures of hexadecane and squalane confined between the tip apex and atomically flat graphite. The shearing amplitudes are typically <2 nm, hence reflecting highly localised information at the interface...
October 14, 2016: Nanoscale
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