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https://www.readbyqxmd.com/read/28101273/who-scared-the-cat-a-molecular-crime-scene-investigation-laboratory-exercise
#1
Laura E Ott, Susan D Carson
This introductory laboratory exercise gives first-year life science majors or nonmajors an opportunity to gain knowledge and experience in basic bioinformatics and molecular biology laboratory techniques and analysis in the context of a mock crime scene investigation. In this laboratory, students determine if a human (Lady) or dog (Kona) committed the fictional crime of scaring a cat. Students begin by performing in silico PCR using provided dog- and human-specific PCR primers to determine the sequences to be amplified and predict PCR amplicon sizes...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28048893/mo-de-209-01-primer-on-tomosynthesis
#2
A Maidment
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048241/mo-de-209-02-tomosynthesis-reconstruction-methods
#3
J Mainprize
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048058/mo-de-209-04-radiation-dosimetry-in-breast-tomosynthesis
#4
I Sechopoulos
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048023/tu-fg-brb-09-thermoacoustic-range-verification-with-perfect-co-registered-overlay-of-bragg-peak-onto-ultrasound-image
#5
S Patch, M Kireeff Covo, A Jackson, Y Qadadha, K Campbell, R Albright, P Bloemhard, A Donoghue, C Siero, T Gimpel, S Small, B Ninemire, M Johnson, L Phair
PURPOSE: The potential of particle therapy has not yet been fully realized due to inaccuracies in range verification. The purpose of this work was to correlate the Bragg peak location with target structure, by overlaying thermoacoustic localization of the Bragg peak onto an ultrasound image. METHODS: Pulsed delivery of 50 MeV protons was accomplished by a fast chopper installed between the ion source and the inflector of the 88″ cyclotron at Lawrence Berkeley National Lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047595/mo-de-209-03-assessing-image-quality
#6
W Zhao
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046829/mo-de-209-00-dbt-physics-basic-to-advanced
#7
Andrew D Maidment
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043965/cell-scientist-to-watch-madeline-lancaster
#8
(no author information available yet)
Madeline Lancaster received her first degree in biochemistry from the Occidental College in Los Angeles, California, and continued to follow her interests by pursuing a PhD in biomedical sciences in the laboratory of Joseph Gleeson at University of California, San Diego. She then left the USA to train as a postdoctoral fellow with Jürgen Knoblich at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna. Madeline was a recipient of the EMBO, Helen Hay Whitney and Marie Curie Incoming Fellowships, and in 2014 her work was recognised when she was awarded the Eppendorf Award for Young Investigators...
January 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28025912/of-spheres-and-squares-can-sloterdijk-help-us-rethink-the-architecture-of-climate-science
#9
Martin Skrydstrup
This article explores how different visions and values of science translate into different architectural shapes. I bring Peter Sloterdijk's 'spherology' to bear on my ethnographic fieldwork at the NEEM ice core base in Greenland, a significant node in the global infrastructure of climate science. I argue that the visual form of the geodesic dome of the camp materializes specific values and visions of this branch of paleoclimate science, which I elaborate vis-a-vis the pragmatic claims of the scientists/designers and the particular architectural history of Danish ice core drilling in Greenland...
December 2016: Social Studies of Science
https://www.readbyqxmd.com/read/28012137/vapros-a-database-integration-approach-for-protein-genome-information-retrieval
#10
Takashi Gojobori, Kazuho Ikeo, Yukie Katayama, Takeshi Kawabata, Akira R Kinjo, Kengo Kinoshita, Yeondae Kwon, Ohsuke Migita, Hisashi Mizutani, Masafumi Muraoka, Koji Nagata, Satoshi Omori, Hideaki Sugawara, Daichi Yamada, Kei Yura
Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures, protein-protein interactions, phenotypes and so forth. The knowledge accumulated by all the omics research is so vast that a computer-aided search of data is now a prerequisite for starting a new study. In addition, a combinatory search throughout these databases has a chance to extract new ideas and new hypotheses that can be examined by wet-lab experiments. By virtually integrating the related databases on the Internet, we have built a new web application that facilitates life science researchers for retrieving experts' knowledge stored in the databases and for building a new hypothesis of the research target...
December 23, 2016: Journal of Structural and Functional Genomics
https://www.readbyqxmd.com/read/28004190/systematic-review-of-the-implementation-of-simulation-training-in-surgical-residency-curriculum
#11
REVIEW
Yo Kurashima, Satoshi Hirano
PURPOSE: We reviewed the literature regarding the specific methods and strategies for implementing simulation-based training into the modern surgical residency curriculum. Residency programs are still struggling with how best to implement it into their curricula from a practical viewpoint. METHODS: A systematic review was performed using Ovid MEDLINE, EMBASE, PubMed, PsycINFO, Web of Science, and other resources for studies involving the use of simulation for technical skills training in the surgical residency curriculum...
December 22, 2016: Surgery Today
https://www.readbyqxmd.com/read/27965547/regular-cycles-of-forward-and-backward-signal-propagation-in-prefrontal-cortex-and-in-consciousness
#12
Paul J Werbos, Joshua J J Davis
This paper addresses two fundamental questions: (1) Is it possible to develop mathematical neural network models which can explain and replicate the way in which higher-order capabilities like intelligence, consciousness, optimization, and prediction emerge from the process of learning (Werbos, 1994, 2016a; National Science Foundation, 2008)? and (2) How can we use and test such models in a practical way, to track, to analyze and to model high-frequency (≥ 500 hz) many-channel data from recording the brain, just as econometrics sometimes uses models grounded in the theory of efficient markets to track real-world time-series data (Werbos, 1990)? This paper first reviews some of the prior work addressing question (1), and then reports new work performed in MATLAB analyzing spike-sorted and burst-sorted data on the prefrontal cortex from the Buzsaki lab (Fujisawa et al...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27932550/spermaurin-an-la1-like-peptide-from-the-venom-of-the-scorpion-scorpio-maurus-palmatus-improves-sperm-motility-and-fertilization-in-different-mammalian-species
#13
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27905056/principal-covariates-clusterwise-regression-pccr-accounting-for-multicollinearity-and-population-heterogeneity-in-hierarchically-organized-data
#14
Tom Frans Wilderjans, Eva Vande Gaer, Henk A L Kiers, Iven Van Mechelen, Eva Ceulemans
In the behavioral sciences, many research questions pertain to a regression problem in that one wants to predict a criterion on the basis of a number of predictors. Although in many cases, ordinary least squares regression will suffice, sometimes the prediction problem is more challenging, for three reasons: first, multiple highly collinear predictors can be available, making it difficult to grasp their mutual relations as well as their relations to the criterion. In that case, it may be very useful to reduce the predictors to a few summary variables, on which one regresses the criterion and which at the same time yields insight into the predictor structure...
November 30, 2016: Psychometrika
https://www.readbyqxmd.com/read/27899505/an-interview-with-david-mcclay
#15
Aidan Maartens
David McClay is the Arthur S. Pearse Professor of Biology at Trinity College of Arts and Sciences, Duke University, North Carolina. His lab works on the transcriptional control of morphogenesis in the sea urchin embryo. We caught up with David at the 2016 Society for Developmental Biology - International Society of Differentiation joint meeting in Boston, where he received the Lifetime Achievement Award.
December 1, 2016: Development
https://www.readbyqxmd.com/read/27885317/poetry-and-neuroscience-an-interdisciplinary-conversation
#16
James Wilkes, Sophie K Scott
Dialogues and collaborations between scientists and non-scientists are now widely understood as important elements of scientific research and public engagement with science. In recognition of this, the authors, a neuroscientist and a poet, use a dialogical approach to extend questions and ideas first shared during a lab-based poetry residency. They recorded a conversation and then expanded it into an essayistic form, allowing divergent disciplinary understandings and uses of experiment, noise, voice and emotion to be articulated, shared and questioned...
2016: Configurations
https://www.readbyqxmd.com/read/27869519/a-post-planktonic-era-of-in-vitro-infectious-models-issues-and-changes-addressed-by-a-clinically-relevant-wound-like-media
#17
Urvish Trivedi, Jonas S Madsen, Kendra P Rumbaugh, Randall D Wolcott, Mette Burmølle, Søren J Sørensen
Medical science is pitted against an ever-increasing rise in antibiotic tolerant microorganisms. Concurrently, during the past decade, biofilms have garnered much attention within research and clinical practice. Although the significance of clinical biofilms is becoming very apparent, current methods for diagnostics and direction of therapy plans in many hospitals do not reflect this knowledge; with many of the present tools proving to be inadequate for accurately mimicking the biofilm phenomenon. Based on current findings, we address some of the fundamental issues overlooked by clinical labs: the paradigm shifts that need to occur in assessing chronic wounds; better simulation of physiological conditions in vitro; and the importance of incorporating polymicrobial populations into biofilm models...
November 21, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27856549/investigating-the-role-of-an-inquiry-based-biology-lab-course-on-student-attitudes-and-views-toward-science
#18
Erica Jeffery, Kathy Nomme, Thomas Deane, Carol Pollock, Gülnur Birol
Students' academic experiences can influence their conceptualization of science. In contrast experts hold particular beliefs, perceptions, opinions, and attitudes about science that are often absent in first-year undergraduate students. Shifts toward more expert-like attitudes and views have been linked to improved student engagement, critical-thinking ability, conceptual understanding, and academic performance. In this study, we investigate shifts in attitudes and views toward science by students in four biology classes with differences in student enrollment, academic support, and instruction...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27852827/cell-scientist-to-watch-sabine-petry
#19
(no author information available yet)
Originally from Germany, Sabine Petry received her Diploma (MSc) from Goethe University in Frankfurt and undertook her Master's thesis at the Max Planck Institute of Biophysics. She then moved to the UK to pursue a PhD under the supervision of Venki Ramakrishnan at the MRC Laboratory of Molecular Biology in Cambridge. In 2008, Sabine started her postdoctoral work in the laboratory of Ron Vale at the University of California, San Francisco as an EMBO fellow and then an HHMI postdoctoral fellow of the Life Science Research Foundation...
November 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27848190/towards-a-systematic-screening-tool-for-quality-assurance-and-semiautomatic-fraud-detection-for-images-in-the-life-sciences
#20
Lars Koppers, Holger Wormer, Katja Ickstadt
The quality and authenticity of images is essential for data presentation, especially in the life sciences. Questionable images may often be a first indicator for questionable results, too. Therefore, a tool that uses mathematical methods to detect suspicious images in large image archives can be a helpful instrument to improve quality assurance in publications. As a first step towards a systematic screening tool, especially for journal editors and other staff members who are responsible for quality assurance, such as laboratory supervisors, we propose a basic classification of image manipulation...
November 15, 2016: Science and Engineering Ethics
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