keyword
MENU ▼
Read by QxMD icon Read
search

Lab science

keyword
https://www.readbyqxmd.com/read/29655519/much-ado-about-mice-standard-setting-in-model-organism-research
#1
Rebecca A Hardesty
Recently there has been a practice turn in the philosophy of science that has called for analyses to be grounded in the actual doings of everyday science. This paper is in furtherance of this call and it does so by employing participant-observation ethnographic methods as a tool for discovering epistemological features of scientific practice in a neuroscience lab. The case I present focuses on a group of neurobiologists researching the genetic underpinnings of cognition in Down syndrome (DS) and how they have developed a new mouse model which they argue should be regarded as the "gold standard" for all DS mouse research...
April 11, 2018: Studies in History and Philosophy of Biological and Biomedical Sciences
https://www.readbyqxmd.com/read/29650763/first-person-xuan-xie
#2
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Xuan Xie is the first author on 'Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities', published in Journal of Cell Science. Xuan is a PhD student in the lab of Masayuki Komada at the Tokyo Institute of Technology, Yokohama, Japan, investigating the roles of ubiquitylation and deubiquitylation in the regulation of stress granules...
April 12, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29643891/assessment-of-freshwater-springs-associated-diseases-and-indigenous-perception-in-ghizer-gilgit-baltistan-pakistan
#3
Shaukat Ali, Rubina, Sadiq Hussain
Objective: To assess the quality of freshwater aquifers (springs) associated diseases, and indigenous perception in Ghizer, Gilgit-Baltistan. Methods: This was a cross-sectional study conducted at the department of environmental science, Karakoram International University Gilgit after approval from departmental research committee. In order to get the most accurate results, 18 water samples in triplicates were collected according to our lab own set of sampling standard operating procedures (SOPs) using pre-sterilized bottles of 100 ml from June 2016 to August 2016 along with associated diseases record and structured interviews from indigenous population...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29618182/accuracy-of-imputation-of-microsatellite-markers-from-bovinesnp50-and-bovinehd-beadchip-in-hanwoo-population-of-korea
#4
Aditi Sharma, Jong-Eun Park, Byungho Park, Mi-Na Park, Seung-Hee Roh, Woo-Young Jung, Seung-Hwan Lee, Han-Ha Chai, Gul-Won Chang, Yong-Min Cho, Dajeong Lim
Until now microsatellite (MS) have been a popular choice of markers for parentage verification. Recently many countries have moved or are in process of moving from MS markers to single nucleotide polymorphism (SNP) markers for parentage testing. FAO-ISAG has also come up with a panel of 200 SNPs to replace the use of MS markers in parentage verification. However, in many countries most of the animals were genotyped by MS markers till now and the sudden shift to SNP markers will render the data of those animals useless...
March 2018: Genomics & Informatics
https://www.readbyqxmd.com/read/29595784/why-laughter-in-the-lab-can-help-your-science
#5
Amber Dance
No abstract text is available yet for this article.
March 29, 2018: Nature
https://www.readbyqxmd.com/read/29581688/introducing-in-vivo-dissection-modules-for-undergraduate-level-trainees-what-is-the-actual-benefit-and-how-could-we-make-it-more-efficient
#6
Michail Sideris, Apostolos Papalois, Korina Theodoraki, Georgios Paparoidamis, Nikolaos Staikoglou, Ismini Tsagkaraki, Efstratios Koletsis, Panagiotis Dedeilias, Nikolaos Lymperopoulos, Konstantinos Imprialos, Savvas Papagrigoriadis, Vassilios Papalois, Georgios Zografos, Georgios Tsoulfas
Essential Skills in the Management of Surgical Cases (ESMSC) is an international wet lab simulation course aimed at undergraduate students. It combines basic science workshops, case-based lectures and ex vivo skills modules, as well as in vivo dissections using a swine model. This study aims to evaluate the effectiveness of high-fidelity In Vivo Simulation-Based Learning for undergraduate level trainees. Also our goal was to compare the skill-based performance of final year students vs. more junior-level ones...
February 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29571046/the-contributions-of-dr-kathleen-k-sulik-to-fetal-alcohol-spectrum-disorders-research-and-prevention
#7
REVIEW
Scott E Parnell, Edward P Riley, Kenneth R Warren, Kathleen T Mitchell, Michael E Charness
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career...
March 20, 2018: Alcohol
https://www.readbyqxmd.com/read/29548829/lab-scale-evaluation-of-aerated-burial-concept-for-treatment-and-emergency-disposal-of-infectious-animal-carcasses
#8
Jacek A Koziel, Heekwon Ahn, Thomas D Glanville, Timothy S Frana, J Hans van Leeuwen, Lam T Nguyen
Nearly 55,000 outbreaks of animal disease were reported to the World Animal Health Information Database between 2005 and 2016. To suppress the spread of disease, large numbers of animal mortalities often must be disposed of quickly and are frequently buried on the farm where they were raised. While this method of emergency disposal is fast and relatively inexpensive, it also can have undesirable and lasting impacts (slow decay, concerns about groundwater contamination, pathogens re-emergence, and odor). Following the 2010 foot-and-mouth disease outbreak, the Republic of Korea's National Institute of Animal Science funded research on selected burial alternatives or modifications believed to have potential to reduce undesirable impacts of burial...
March 13, 2018: Waste Management
https://www.readbyqxmd.com/read/29545286/an-interview-with-susan-strome
#9
Aidan Maartens
Susan Strome is Distinguished Professor of Molecular, Cell and Developmental Biology at the University of California, Santa Cruz, USA. Recently appointed an editor at Development, her lab studies the regulation of germ cell development in C. elegans , with a particular focus on the epigenetic transmission of chromatin states. We caught up with Susan to discuss her early career switch from prokaryotes to worms, her experiences of small and big science, and why teaching is so important to her.
March 15, 2018: Development
https://www.readbyqxmd.com/read/29519810/developing-a-novel-international-undergraduate-surgical-masterclass-during-a-financial-crisis-our-4-year-experience
#10
Michail Sideris, John Hanrahan, Georgios Tsoulfas, Iakovos Theodoulou, Fatema Dhaif, Vassilios Papalois, Savvas Papagrigoriadis, George Velmahos, Patricia Turner, Apostolos Papalois
BACKGROUND: Essential Skills in the Management of Surgical Cases (ESMSC) is a novel 3-day international undergraduate surgical masterclass. Its current curriculum (Cores integrated for Research-Ci4R) is built on a tetracore, multiclustered architecture combining high-fidelity and low-fidelity simulation-based learning (SBL), with applied and basic science case-based workshops, and non-technical skills modules. We aimed to report our experience in setting up ESMSC during the global financial crisis...
March 8, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29504019/assessing-the-impact-of-a-virtual-lab-in-an-allied-health-program
#11
Robin Kay, Helene Goulding, Jia Li
Competency-based education in health care requires rigorous standards to ensure professional proficiency. Demonstrating competency in hands-on laboratories calls for effective preparation, knowledge, and experience, all of which can be difficult to achieve using traditional teaching methods. Virtual laboratories are an alternative, cost-effective approach to providing students with sufficient preparatory information. Research on the use of virtual labs in allied health education is limited. The current study investigated the benefits, challenges, and perceived impact of a virtual lab in an allied health program...
2018: Journal of Allied Health
https://www.readbyqxmd.com/read/29500320/first-person-anuttoma-ray
#12
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Anuttoma Ray is the first author on 'Dileucine-like motifs in the C-terminal tail of connexin32 control its endocytosis and assembly into gap junctions', published in Journal of Cell Science. Anuttoma is a PhD student in the lab of Dr Parmender P. Mehta at the University of Nebraska Medical Center, Omaha, USA, investigating the molecular mechanisms that regulate assembly of connexins into gap junctions...
March 2, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29491155/copy-number-heterogeneity-large-origin-tandem-repeats-and-interspecies-recombination-in-hhv-6a-and-hhv-6b-reference-strains
#13
Alexander L Greninger, Pavitra Roychoudhury, Negar Makhsous, Derek Hanson, Jill Chase, Gerhard Krueger, Hong Xie, Meei-Li Huang, Lindsay Saunders, Dharam Ablashi, David M Koelle, Linda Cook, Keith R Jerome
Quantitative PCR is the diagnostic pillar for clinical virology testing, and reference materials are necessary for accurate, comparable quantitation between clinical laboratories. Accurate quantitation of HHV-6A/B is important for detection of viral reactivation and inherited chromosomally integrated HHV-6A/B in immunocompromised patients. Reference materials in clinical virology commonly consist of laboratory-adapted viral strains that may be affected by the culture process. We performed next-generation sequencing to make relative copy number measurements at single nucleotide resolution of eight candidate HHV-6A and seven HHV-6B reference strains and DNA materials from the HHV-6 Foundation and Advanced Biotechnologies...
February 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29487106/an-interview-with-yk%C3%A3-helariutta
#14
Aidan Maartens
Yrjö (Ykä) Helariutta is a group leader at The Institute of Biotechnology in the University of Helsinki and at the Sainsbury Laboratory in the University of Cambridge. Recently appointed an editor at Development, his lab works on vascular development in plants and trees. We met Ykä in his Cambridge office to hear how a childhood passion for collecting led him to plant science, what Arabidopsis can tell us about trees and vice versa, and why he thinks there are many different ways of being successful in science...
February 27, 2018: Development
https://www.readbyqxmd.com/read/29453261/molecular-and-functional-study-of-a-branching-sucrase-like-glucansucrase-reveals-an-evolutionary-intermediate-between-two-subfamilies-of-the-gh70-enzymes
#15
Minghui Yan, Bing-Hua Wang, Xiaofen Xu, Peng Chang, Feng Hang, Zhengjun Wu, Chunping You, Zhenmin Liu
Family GH70 glucansucrases (GSs) catalyze the synthesis of α-glucans from sucrose, a reaction widely seen in lactic acid bacteria (LAB). These enzymes have been implicated in many aspects of the microbial life. Products of GSs have great commercial value as food supplements and medical materials, therefore these enzymes have attracted much attention from both fields of science and industry. However, certain issues concerning the origin and evolution of GS are still to be addressed, although an increasing number of GH70 enzymes have been characterized...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29451391/the-future-of-lc-ms-for-pharmaceutical-analysis-an-interview-with-jun-qu
#16
Jun Qu
Jun Qu speaks to Sankeetha Nadarajah, Editor of Bioanalysis: Jun Qu is the group leader of the proteomics and pharmaceutical analysis lab of SUNY-Buffalo (NY, USA) and a Professor in the Department of Pharmaceutical Sciences. His research is focused on the study of Clinical and Pharmaceutical Proteomics and Pharmaceutical Analysis using LC-MS-based strategies. His research programs include high-resolution and large-scale expression profiling of pathological proteomes, for the discovery of novel disease/therapeutics biomarkers using gel-free proteomic methods; sensitive identification, localization and quantification of post-translational modifications in tissue proteomes such as these in myocardium, using novel anti-PTM affinity capture and alternating Collision-induced dissociation/Electron transfer dissociation to obtain abundant PTM information; targeted investigation of marker proteins that are of high interests for clinical and pharmaceutical study, using highly sensitive nano-LC/SRM-based methods; and highly sensitive and accurate investigation of the PK of biotherapeutics using LC-MS...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29444954/invite-your-representative-to-work-change-the-world-here-s-how
#17
Denise J Montell
Today's political climate can seem hostile to science. Alternative facts, climate change denial, and relabeling of actual news as fake news are discouraging phenomena for sure. But these trends make it more important than ever to engage our politicians. Take heart! There is something you can do. You can show your representatives firsthand the amazing things you do, evidence of the economic engine that your activities generate, and the real people behind the discoveries. I did, and it was fun. We invited our congressman to the University of California, Santa Barbara (UCSB), and he accepted! For 2 hours, we explained and demonstrated efforts to cure blindness using stem cells, the medical implications of the discovery that cells can recover from the brink of death, a mosquito lab striving to eliminate insect-borne disease, and an Alzheimer's disease laboratory...
February 15, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29432479/quality-science-from-quality-measurement-the-role-of-measurement-type-with-respect-to-replication-and-effect-size-magnitude-in-psychological-research
#18
Diana E Kornbrot, Richard Wiseman, George J Georgiou
The quality of psychological studies is currently a major concern. The Many Labs Project (MLP) and the Open-Science-Collaboration (OSC) have collected key data on replicability and statistical effect sizes. We build on this work by investigating the role played by three measurement types: ratings, proportions and unbounded (measures without conceptual upper limits, e.g. time). Both replicability and effect sizes are dependent on the amount of variability due to extraneous factors. We predicted that the role of such extraneous factors might depend on measurement type, and would be greatest for ratings, intermediate for proportions and least for unbounded...
2018: PloS One
https://www.readbyqxmd.com/read/29431640/first-person-guillaume-hatte
#19
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Guillaume Hatte is the first author on 'Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue', published in Journal of Cell Science. Guillaume completed his PhD in the lab of Claude Prigent at CNRS UMR 6290 and Université de Rennes 1, Rennes, France, where he investigated the involvement of tight junctions during epithelial cell cytokinesis in a vertebrate model...
February 5, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29409535/dmto-a-realistic-ontology-for-standard-diabetes-mellitus-treatment
#20
Shaker El-Sappagh, Daehan Kwak, Farman Ali, Kyung-Sup Kwak
BACKGROUND: Treatment of type 2 diabetes mellitus (T2DM) is a complex problem. A clinical decision support system (CDSS) based on massive and distributed electronic health record data can facilitate the automation of this process and enhance its accuracy. The most important component of any CDSS is its knowledge base. This knowledge base can be formulated using ontologies. The formal description logic of ontology supports the inference of hidden knowledge. Building a complete, coherent, consistent, interoperable, and sharable ontology is a challenge...
February 6, 2018: Journal of Biomedical Semantics
keyword
keyword
50165
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"