Read by QxMD icon Read

Lab science

Susanne E Hall, Christina Birch
Creating and teaching successful writing and communication assignments for biology undergraduate students can be challenging for faculty trying to balance the teaching of technical content. The growing body of published research and scholarship on effective teaching of writing and communication in biology can help inform such work, but there are also local resources available to support writing within biology courses that may be unfamiliar to science faculty and instructors. In this article, we discuss common on-campus resources biology faculty can make use of when incorporating writing and communication into their teaching...
2018: Journal of Microbiology & Biology Education: JMBE
David Drubin
Recent articles published in the popular press have highlighted how science can go wrong; alarmingly, when some labs have attempted to reproduce results of already published data from preclinical studies, they have reported being successful only 12%-25% of the time. Since there is a lack of consensus about this problem, this talk focusses on the magnitude and applicability of the problem of reproducibility and what journals can do to address it. This article is protected by copyright. All rights reserved.
June 14, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Marlene Zuk, Mike Travisano
Models are universal in science, both as theoretical formulations of reality and as model systems, representatives of other organisms. A recent paper on how scientists view the world divides our work into the mind, the lab, and the field and suggests that models must not be conflated with reality. But in practice, these distinctions are blurred. For example, are flour beetles a model system for other insects when their natural habitat is the same as the way they live in the lab? In addition, models can become restrictive when they are viewed as archetypes, making us overgeneralize about the world and ignoring meaningful variation...
July 2018: American Naturalist
Azadeh Kamel Ghalibaf, Majid Jangi, Mohammad Reza Mazaheri Habibi, Sara Zangouei, Reza Khajouei
Background and aim: Obstetrics and gynecology information system is a critical component of the HIS in social security organization health centers. The objective of this study was to evaluate the usability of this system using the cognitive walkthrough method. Also, the present study provided a detailed formal description of how the cognitive usability evaluation can be applied and reported for a health care information system. Methods: This study was conducted at the Mashhad University of Medical Sciences' usability lab from March 2016 to June 2017...
April 2018: Electronic Physician
Utkarsha A Singh, Mukta Kumari, Soumya Iyengar
Background: Although genomic DNA isolation using the Chelex 100 resin is rapid and inexpensive, the DNA obtained by this method has a low concentration in solution and contains suspended impurities. The presence of debris in the DNA solution may result in degradation of DNA on long term storage and inhibition of the polymerase chain reaction. In order to remove impurities and concentrate the DNA in solution, we have introduced modifications in the existing DNA isolation protocol using Chelex-100...
2018: Biological Procedures Online
Petr Brůha, Roman Mouček, Vítězslav Vacek, Pavel Šnejdar, Kateřina Černá, Petr Řehoř
Smoking, excessive drinking, overeating and physical inactivity are well-established risk factors decreasing human physical performance. Moreover, epidemiological work has identified modifiable lifestyle factors, such as poor diet and physical and cognitive inactivity that are associated with the risk of reduced cognitive performance. Definition, collection and annotation of human reaction times and suitable health related data and metadata provides researchers with a necessary source for further analysis of human physical and cognitive performance...
April 2018: Data in Brief
Kendall Powell
No abstract text is available yet for this article.
June 2018: Nature
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Frances Tilley is the first author on 'Retromer associates with the cytoplasmic amino-terminus of polycystin-2', published in Journal of Cell Science. Frances conducted the work in this article while a PhD student in the lab of Peter Cullen at the University of Bristol, UK, but is now a postdoc in Corinne Antignac's lab at Imagine Institute, Paris, France, investigating the mechanisms of pathogenesis in Galloway-Mowat syndrome, with a focus on the role of podocytes on disease progression...
June 6, 2018: Journal of Cell Science
Jianmin Gu, Baipeng Yin, Shaoyan Fu, Man Feng, Ziming Zhang, Haiyun Dong, Faming Gao, Yong Sheng Zhao
Directing the architecture of complex organic nanostructures is desirable and still remains a challenge in areas of materials science due to their structure-dependent collective optoelectronic properties. Herein, we demonstrate a simple and versatile solution strategy that allows surface tension to drive low-dimensional nanostructures to aggregate into complex structures via a lab in a droplet technique. By selecting a suitable combination of a solvent and an anti-solvent with controllable surface tension difference, the droplets can be automatically cracked into micro-droplets, which provides an aggregation force directed toward the centre of the droplet to drive the low-dimensional building blocks to form the special aggregations during the self-assembly process...
June 5, 2018: Nanoscale
Krishanu Nandy, David W Collinson, Charlie M Scheftic, L Catherine Brinson
The cost of specialized scientific equipment can be high and with limited funding resources, researchers and students are often unable to access or purchase the ideal equipment for their projects. In the fields of materials science and mechanical engineering, fundamental equipment such as tensile testing devices can cost tens to hundreds of thousands of dollars. While a research lab often has access to a large-scale testing machine suitable for conventional samples, loading devices for meso- and micro-scale samples for in-situ testing with the myriad of microscopy tools are often hard to source and cost prohibitive...
2018: PloS One
Elizabeth O'Day, Leticia Hosta-Rigau, Diego A Oyarzún, Hideyuki Okano, Víctor de Lorenzo, Conrad von Kameke, Habiba Alsafar, Cong Cao, Guo-Qiang Chen, Weizhi Ji, Richard J Roberts, Mostafa Ronaghi, Karen Yeung, Feng Zhang, Sang Yup Lee
Patient X: A 67-year-old Caucasian man slips on a patch of ice. He has abrasions to his hands and has sustained significant damage to his hip. At the emergency room, he informs clinicians he takes atorvastatin, metformin and glimepiride to treat hypertension and Type 2 Diabetes Mellitus (T2DM). X-rays reveal a fractured hip, which will require total hip replacement surgery. Biotechnology is a major force poised to help us to live longer and healthier lives. In 2015, the United Nations defined 17 Sustainable Development Goals aimed at providing an all-encompassing framework for improving the state of the world (**)...
May 24, 2018: Biotechnology Journal
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Pawel Leznicki is the first author on 'Expansion of DUB functionality generated by alternative isoforms - USP35, a case study', published in Journal of Cell Science. Pawel conducted the research in this article while in Yogesh Kulathu's lab at the University of Dundee, UK. He is now a research associate in the lab of Stephen High at the University of Manchester, UK, investigating protein biogenesis processes and their quality control...
May 16, 2018: Journal of Cell Science
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Chih-Wen Chu is the first author on 'The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure', published in Journal of Cell Science. Chih-Wen is an associate scientist in the lab of Sergei Sokol at Icahn School of Medicine at Mount Sinai, New York, USA, investigating apical constriction and planar cell polarity, with a focus on protein dynamics at the cell junctions...
May 16, 2018: Journal of Cell Science
Mudasir Bashir Gugjoo, Amarpal, Vikash Chandra, Mohd Yaqoob Wani, Kuldeep Dhama, Gutulla Taru Sharma
BACKGROUND: The stem cells due to their unique characteristic features like self-renewal, multiplication, immuno-modulation and differentiation, are seen and hoped to bring new horizons in the field of biology, in general and medicine, in particular. OBJECTIVE: Among various stem cell types, currently mesenchymal stem cells (MSCs) are extensively studied in regenerative medicine owing to their readily available sources, easy harvesting and ability to differentiate both into mesodermal as well as non-mesodermal tissues with little associated ethical issues...
May 16, 2018: Current Stem Cell Research & Therapy
Suresh K Vasa, Petra Rovó, Rasmus Linser
Solid-state nuclear magnetic resonance (ssNMR) is a spectroscopic technique that is used for characterization of molecular properties in the solid phase at atomic resolution. In particular, using the approach of magic-angle spinning (MAS), ssNMR has seen widespread applications for topics ranging from material sciences to catalysis, metabolomics, and structural biology, where both isotropic and anisotropic parameters can be exploited for a detailed assessment of molecular properties. High-resolution detection of protons long represented the holy grail of the field...
May 15, 2018: Accounts of Chemical Research
Lisa A Corwin, Christopher R Runyon, Eman Ghanem, Moriah Sandy, Greg Clark, Gregory C Palmer, Stuart Reichler, Stacia E Rodenbusch, Erin L Dolan
Course-based undergraduate research experiences (CUREs) provide a promising avenue to attract a larger and more diverse group of students into research careers. CUREs are thought to be distinctive in offering students opportunities to make discoveries, collaborate, engage in iterative work, and develop a sense of ownership of their lab course work. Yet how these elements affect students' intentions to pursue research-related careers remain unexplored. To address this knowledge gap, we collected data on three design features thought to be distinctive of CUREs (discovery, iteration, collaboration) and on students' levels of ownership and career intentions from ∼800 undergraduates who had completed CURE or inquiry courses, including courses from the Freshman Research Initiative (FRI), which has a demonstrated positive effect on student retention in college and in science, technology, engineering, and mathematics...
June 2018: CBE Life Sciences Education
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Julia Abitbol is the first author on 'Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss', published in Journal of Cell Science. Julia is a PhD student in the lab of Dale Laird at the University of Western Ontario, Canada, investigating the mechanisms of connexin-induced hearing loss...
May 4, 2018: Journal of Cell Science
Pablo Rey-Mazón, Hagit Keysar, Shannon Dosemagen, Catherine D'Ignazio, Don Blair
This paper explores three cases of Do-It-Yourself, open-source technologies developed within the diverse array of topics and themes in the communities around the Public Laboratory for Open Technology and Science (Public Lab). These cases focus on aerial mapping, water quality monitoring and civic science practices. The techniques discussed have in common the use of accessible, community-built technologies for acquiring data. They are also concerned with embedding collaborative and open source principles into the objects, tools, social formations and data sharing practices that emerge from these inquiries...
May 3, 2018: Science and Engineering Ethics
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Varun Jayeshkumar Shah is the first author on 'CRL7SMU1 E3 ligase complex-driven H2B ubiquitination functions in sister chromatid cohesion by regulating SMC1 expression', published in Journal of Cell Science. Varun is a PhD student in the lab of Dr Subbareddy Maddika at the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India, investigating the role of LisH-domain-containing proteins in the assembly of multi-subunit E3 ligase complexes...
April 26, 2018: Journal of Cell Science
Priscila A Maranhão, Gustavo Bacelar-Silva, Duarte Gonçalves-Ferreira, Pedro Vieira-Marques, Ricardo Cruz-Correia
Since the Human Genomic Project discovered the sequencing of human genome, the interest about genome content in clinical practice has increased. Genetic information has become a key point to understand diseases or improve treatments, for example, the nutrigenomic and nutrigenetics. However, the huge amount of data generated raises the need for Electronic Health Record (EHR) improvements as it becomes increasingly necessary that it includes more specific genetic information. Thus, we aim to propose standard genetic archetypes (in openEHR) and describe our main challenges in this context...
2018: Studies in Health Technology and Informatics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"