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https://www.readbyqxmd.com/read/28211993/recent-lab-on-chip-developments-for-novel-drug-discovery
#1
REVIEW
Nauman Khalid, Isao Kobayashi, Mitsutoshi Nakajima
Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS) revolutionized the biochemical and electronic industries, and this miniaturization process became a key driver for many markets. Now, it is a driving force for innovations in life sciences, diagnostics, analytical sciences, and chemistry, which are called 'lab-on-a-chip, (LOC)' devices. The use of these devices allows the development of fast, portable, and easy-to-use systems with a high level of functional integration for applications such as point-of-care diagnostics, forensics, the analysis of biomolecules, environmental or food analysis, and drug development...
February 17, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28197569/microfabricated-tools-for-quantitative-plant-biology
#2
Meltem Elitaş, Meral Yüce, Hikmet Budak
The development of microfabricated devices that will provide high-throughput quantitative data and high resolution in a fast, repeatable and reproducible manner is essential for plant biology research. Plants have been intensely explored since the beginning of humanity, especially for medical needs. However, plant biology research is still laborious, lacking the latest technological advancements in the laboratory practices. Microfabricated tools can provide a significant contribution to plant biology research since they require small volumes of samples and reagents with minimal cost and labor...
February 15, 2017: Analyst
https://www.readbyqxmd.com/read/28196473/2-7-million-samples-genotyped-for-hla-by-next-generation-sequencing-lessons-learned
#3
Gerhard Schöfl, Kathrin Lang, Philipp Quenzel, Irina Böhme, Jürgen Sauter, Jan A Hofmann, Julia Pingel, Alexander H Schmidt, Vinzenz Lange
BACKGROUND: At the DKMS Life Science Lab, Next Generation Sequencing (NGS) has been used for ultra-high-volume high-resolution genotyping of HLA loci for the last three and a half years. Here, we report on our experiences in genotyping the HLA, CCR5, ABO, RHD and KIR genes using a direct amplicon sequencing approach on Illumina MiSeq and HiSeq 2500 instruments. RESULTS: Between January 2013 and June 2016, 2,714,110 samples largely from German, Polish and UK-based potential stem cell donors have been processed...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28193243/bite-size-research-bmc-research-notes-goes-back-to-its-roots
#4
EDITORIAL
Dirk Krüger, Diana M Marshall
Since it first launched in 2008, BMC Research Notes has been a place where researchers can publish short notes and observations, research outputs which are useful for the community but which can end up hidden in the lab notebook or as a footnote in a dataset. In order to re-affirm the importance of publishing these kinds of outputs, the journal is renewing its focus on publishing note articles as well as other potentially dark data such as short null results. Publishing these articles is useful for many researchers, therefore we are also expanding the scope to all scientific and clinical disciplines including health sciences, life sciences, physical sciences, mathematics and all engineering disciplines...
February 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28186046/building-research-capacity-results-of-a-feasibility-study-using-a-novel-mhealth-epidemiological-data-collection-system-within-a-gestational-diabetes-population
#5
Allen McLean, Nathaniel Osgood, Jill Newstead-Angel, Kevin Stanley, Dylan Knowles, William van der Kamp, Weicheng Qian, Roland Dyck
Public health researchers have traditionally relied on individual self-reporting when collecting much epidemiological surveillance data. Data acquisition can be costly, difficult to acquire, and the data often notoriously unreliable. An interesting option for the collection of individual health (or indicators of individual health) data is the personal smartphone. Smartphones are ubiquitous, and the required infrastructure is well-developed across Canada, including many remote areas. Researchers and health professionals are asking themselves how they might exploit increasing smartphone uptake for the purposes of data collection, hopefully leading to improved individual and public health...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28178270/encouraging-entrepreneurship-in-university-labs-research-activities-research-outputs-and-early-doctorate-careers
#6
Michael Roach
This paper investigates how the encouragement of entrepreneurship within university research labs relates with research activities, research outputs, and early doctorate careers. Utilizing a panel survey of 6,840 science & engineering doctoral students at 39 R1 research universities, this study shows that entrepreneurship is widely encouraged across university research labs, ranging from 54% in biomedical engineering to 18% in particle physics, while only a small share of labs openly discourage entrepreneurship, from approximately 3% in engineering to approximately 12% in the life sciences...
2017: PloS One
https://www.readbyqxmd.com/read/28177855/retraction-of-unlocking-past-emotion-verb-use-affects-mood-and-happiness
#7
(no author information available yet)
The following article has been retracted by the Editor and publishers of Psychological Science: Hart, W. (2013). Unlocking past emotion: Verb use affects mood and happiness. Psychological Science, 24, 19-26. doi: 10.1177/0956797612446351 The retraction follows an investigation by the University of Alabama's Office for Research Compliance. That investigation found that a former graduate student in William Hart's lab altered the data in strategic ways. The investigation found that William Hart was unaware when the article was published that the data had been manipulated...
February 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28168694/the-optimization-of-electrophoresis-on-a-glass-microfluidic-chip-and-its-application-in-forensic-science
#8
Jun P Han, Jing Sun, Le Wang, Peng Liu, Bin Zhuang, Lei Zhao, Yao Liu, Cai X Li
Microfluidic chips offer significant speed, cost, and sensitivity advantages, but numerous parameters must be optimized to provide microchip electrophoresis detection. Experiments were conducted to study the factors, including sieving matrices (the concentration and type), surface modification, analysis temperature, and electric field strengths, which all impact the effectiveness of microchip electrophoresis detection of DNA samples. Our results showed that the best resolution for ssDNA was observed using 4...
February 7, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28159796/a-model-for-designing-adaptive-laboratory-evolution-experiments
#9
Ryan A LaCroix, Bernhard O Palsson, Adam M Feist
: The occurrence of mutations is a cornerstone of the evolutionary theory of adaptation, capitalizing on the rare chance that a mutation confers a fitness benefit. Natural selection is increasingly being leveraged in laboratory settings for industrial and basic science applications. Despite an increasing deployment, there are no standardized procedures available for designing and performing adaptive laboratory evolution (ALE) experiments. Thus, there is a need to optimize the experimental design, specifically for determining when to consider an experiment complete and for balancing outcomes with available resources (i...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28157497/big-data-driven-stem-cell-science-and-tissue-engineering-vision-and-unique-opportunities
#10
Antonio Del Sol, Hans J Thiesen, Jaime Imitola, Rafael E Carazo Salas
Achieving the promises of stem cell science to generate precise disease models and designer cell samples for personalized therapeutics will require harnessing pheno-genotypic cell-level data quantitatively and predictively in the lab and clinic. Those requirements could be met by developing a Big-Data-driven stem cell science strategy and community.
February 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28148738/cell-scientist-to-watch-andrew-holland
#11
(no author information available yet)
Andrew received his first degree in natural sciences from the University of Cambridge and a Masters degree from the University of Manchester, followed by a PhD with Stephen Taylor in Manchester. He then moved to California in 2007 with an EMBO long-term fellowship for his postdoctoral research with Don Cleveland at the Ludwig Institute for Cancer Research. In 2013, Andrew started his own lab as an Assistant Professor in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine, having been named a Kimmel Scholar and a Pew-Stewart Scholar in 2014...
February 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28148277/safe-sparql-federation-over-rdf-data-cubes-with-access-control
#12
Yasar Khan, Muhammad Saleem, Muntazir Mehdi, Aidan Hogan, Qaiser Mehmood, Dietrich Rebholz-Schuhmann, Ratnesh Sahay
BACKGROUND: Several query federation engines have been proposed for accessing public Linked Open Data sources. However, in many domains, resources are sensitive and access to these resources is tightly controlled by stakeholders; consequently, privacy is a major concern when federating queries over such datasets. In the Healthcare and Life Sciences (HCLS) domain real-world datasets contain sensitive statistical information: strict ownership is granted to individuals working in hospitals, research labs, clinical trial organisers, etc...
February 1, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28128213/high-throughput-automated-microfluidic-sample-preparation-for-accurate-microbial-genomics
#13
Soohong Kim, Joachim De Jonghe, Anthony B Kulesa, David Feldman, Tommi Vatanen, Roby P Bhattacharyya, Brittany Berdy, James Gomez, Jill Nolan, Slava Epstein, Paul C Blainey
Low-cost shotgun DNA sequencing is transforming the microbial sciences. Sequencing instruments are so effective that sample preparation is now the key limiting factor. Here, we introduce a microfluidic sample preparation platform that integrates the key steps in cells to sequence library sample preparation for up to 96 samples and reduces DNA input requirements 100-fold while maintaining or improving data quality. The general-purpose microarchitecture we demonstrate supports workflows with arbitrary numbers of reaction and clean-up or capture steps...
January 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28127350/uncommon-human-urinary-tract-myiasis-due-to-psychoda-sp-larvae-kashan-iran-a-case-report
#14
Sima Rasti, Rouhullah Dehghani, Hassan Naeimi Khaledi, Sayed Mahdi Takhtfiroozeh, Elahe Chimehi
Contamination of human and animal body tissues with flies' larvae and diptera cause myiasis. A 26 yr old female patient refers to Kashan Shahid Beheshti Hospital, central Iran because of urogenital infection, pain in the right part of stomach, smelly and reddish vaginal discharge and frequent urination. In the first checking, urine sample was taken. In the sample, active and alive larvae were seen. The live samples were taken to the Environmental Health Department Lab of Kashan University of Medical Sciences in clean glass jars...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28117566/poly-oligo-ethylene-glycol-methyl-ether-methacrylate-brushes-on-high-%C3%AE%C2%BA-metal-oxide-dielectric-surfaces-for-bioelectrical-environments
#15
Daniel Y Joh, Felicia McGuire, Roozbeh Abedini-Nassab, Joseph B Andrews, Rohan K Achar, Zackary Zimmers, Darush Mozhdehi, Rebecca Blair, Faris Albarghouthi, William Oles, Jacob Richter, Cassio M Fontes, Angus M Hucknall, Benjamin B Yellen, Aaron D Franklin, Ashutosh Chilkoti
Advances in electronics and life sciences have generated interest in "lab-on-a-chip" systems utilizing complementary metal oxide semiconductor (CMOS) circuitry for low-power, portable, and cost-effective biosensing platforms. Here, we present a simple and reliable approach for coating "high-κ" metal oxide dielectric materials with "non-fouling" (protein- and cell-resistant) poly(oligo(ethylene glycol) methyl ether methacrylate (POEGMA) polymer brushes as biointerfacial coatings to improve their relevance for biosensing applications utilizing advanced electronic components...
February 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28111495/public-attitudes-on-the-ethics-of-deceptively-planting-false-memories-to-motivate-healthy-behavior
#16
Robert A Nash, Shari R Berkowitz, Simon Roche
Researchers have proposed that planting false memories could have positive behavioral consequences. The idea of deceptively planting 'beneficial' false memories outside of the laboratory raises important ethical questions, but how might the general public appraise this moral dilemma? In two studies, participants from the USA and UK read about a fictional 'false-memory therapy' that led people to adopt healthy behaviors. Participants then reported their attitudes toward the acceptability of this therapy, via scale-rating (both studies) and open-text (study 2) responses...
November 2016: Applied Cognitive Psychology
https://www.readbyqxmd.com/read/28101273/who-scared-the-cat-a-molecular-crime-scene-investigation-laboratory-exercise
#17
Laura E Ott, Susan D Carson
This introductory laboratory exercise gives first-year life science majors or nonmajors an opportunity to gain knowledge and experience in basic bioinformatics and molecular biology laboratory techniques and analysis in the context of a mock crime scene investigation. In this laboratory, students determine if a human (Lady) or dog (Kona) committed the fictional crime of scaring a cat. Students begin by performing in silico PCR using provided dog- and human-specific PCR primers to determine the sequences to be amplified and predict PCR amplicon sizes...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28048893/mo-de-209-01-primer-on-tomosynthesis
#18
A Maidment
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048241/mo-de-209-02-tomosynthesis-reconstruction-methods
#19
J Mainprize
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048058/mo-de-209-04-radiation-dosimetry-in-breast-tomosynthesis
#20
I Sechopoulos
: Digital Breast Tomosynthesis (DBT) is rapidly replacing mammography as the standard of care in breast cancer screening and diagnosis. DBT is a form of computed tomography, in which a limited set of projection images are acquired over a small angular range and reconstructed into tomographic data. The angular range varies from 15° to 50° and the number of projections varies between 9 and 25 projections, as determined by the equipment manufacturer. It is equally valid to treat DBT as the digital analog of classical tomography - that is, linear tomography...
June 2016: Medical Physics
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