Read by QxMD icon Read

Lab science

Warren Tierney, Martin Schweinsberg, Jennifer Jordan, Deanna M Kennedy, Israr Qureshi, S Amy Sommer, Nico Thornley, Nikhil Madan, Michelangelo Vianello, Eli Awtrey, Luke Lei Zhu, Daniel Diermeier, Justin E Heinze, Malavika Srinivasan, David Tannenbaum, Eliza Bivolaru, Jason Dana, Clintin P Davis-Stober, Christilene du Plessis, Quentin F Gronau, Andrew C Hafenbrack, Eko Yi Liao, Alexander Ly, Maarten Marsman, Toshio Murase, Michael Schaerer, Christina M Tworek, Eric-Jan Wagenmakers, Lynn Wong, Tabitha Anderson, Christopher W Bauman, Wendy L Bedwell, Victoria Brescoll, Andrew Canavan, Jesse J Chandler, Erik Cheries, Sapna Cheryan, Felix Cheung, Andrei Cimpian, Mark A Clark, Diana Cordon, Fiery Cushman, Peter H Ditto, Alice Amell, Sarah E Frick, Monica Gamez-Djokic, Rebecca Hofstein Grady, Jesse Graham, Jun Gu, Adam Hahn, Brittany E Hanson, Nicole J Hartwich, Kristie Hein, Yoel Inbar, Lily Jiang, Tehlyr Kellogg, Nicole Legate, Timo P Luoma, Heidi Maibeucher, Peter Meindl, Jennifer Miles, Alexandra Mislin, Daniel C Molden, Matt Motyl, George Newman, Hoai Huong Ngo, Harvey Packham, P Scott Ramsay, Jennifer L Ray, Aaron M Sackett, Anne-Laure Sellier, Tatiana Sokolova, Walter Sowden, Daniel Storage, Xiaomin Sun, Jay J Van Bavel, Anthony N Washburn, Cong Wei, Erik Wetter, Carlos T Wilson, Sophie-Charlotte Darroux, Eric Luis Uhlmann
We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings...
October 11, 2016: Scientific Data
Dorret I Boomsma
No abstract text is available yet for this article.
October 11, 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
Bahareh Kherzi, Martin Pumera
Self-propelled autonomous nano/micromotors are in the forefront of current materials science and technology research. These small machines convert chemical energy from the environment into propulsion, and they can move autonomously in the environment and are capable of chemotaxis or magnetotaxis. They can be used for drug delivery, microsurgeries or environmental remediation. It is of immense interest from a future biomedical application point of view to understand the motion of the nano/micromotors in microfluidic channels...
October 14, 2016: Nanoscale
Kislon Voïtchovsky
The behaviour of fluids confined in nanoscale gaps plays a central role in molecular science and nanofluidics, with applications ranging from biological function to multiscale printing, osmosis and filtration, lab-on-chip technology and friction reduction. Here atomic force microscopy is used to shear five different mixtures of hexadecane and squalane confined between the tip apex and atomically flat graphite. The shearing amplitudes are typically <2 nm, hence reflecting highly localised information at the interface...
October 14, 2016: Nanoscale
Paul E Smaldino, Richard McElreath
Poor research design and data analysis encourage false-positive findings. Such poor methods persist despite perennial calls for improvement, suggesting that they result from something more than just misunderstanding. The persistence of poor methods results partly from incentives that favour them, leading to the natural selection of bad science. This dynamic requires no conscious strategizing-no deliberate cheating nor loafing-by scientists, only that publication is a principal factor for career advancement...
September 2016: Royal Society Open Science
Dinesh Kumar, Sandeep R Vemula, Narayanaganesh Balasubramanian, Gregory R Cook
Stereoselective indium-mediated organic reactions have enjoyed tremendous growth in the last 25 years. This is in part due to the insensitivity of allylindium to moisture, affording facile and practical reaction conditions coupled with outstanding functional group tolerance and minimal side reactions. Despite the plethora of articles about allylindium, there is much yet to be discovered and exploited for efficient and sustainable synthesis. In this Account, we describe indium-mediated synthetic methods for the preparation of chiral amines with the aim to present a balance of practical method development, novel asymmetric chemistry, and mechanistic understanding that impact multiple chemical and materials science disciplines...
October 4, 2016: Accounts of Chemical Research
Michael J Bernstein, Kiera Reifschneider, Ira Bennett, Jameson M Wetmore
Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy...
September 28, 2016: Science and Engineering Ethics
Marcus Antonius Ynalvez, Ruby A Ynalvez, Enrique Ramírez
We explored the social shaping of science at the micro-level reality of face-to-face interaction in one of the traditional places for scientific activities-the scientific lab. We specifically examined how doctoral students' perception of their: (i) interaction with doctoral mentors (MMI) and (ii) lab social environment (LSE) influenced productivity. Construed as the production of peer-reviewed articles, we measured productivity using total number of articles (TOTAL), number of articles with impact factor greater than or equal to 4...
September 26, 2016: Biochemistry and Molecular Biology Education
Alison L Antes, Adelina Mart, James M DuBois
Principal investigators are responsible for a myriad of leadership and management activities in their work. The practices they use to navigate these responsibilities ultimately influence the quality and integrity of research. However, leadership and management roles in research have received scant empirical examination. Semi-structured interviews with 32 National Institutes of Health (NIH)-funded genetic researchers revealed that they considered leadership and management essential for effective research, but their scientific training inadequately prepared them...
September 19, 2016: Journal of Empirical Research on Human Research Ethics: JERHRE
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
Thomas Greb, Jan U Lohmann
Among the trending topics in the life sciences, stem cells have received a fair share of attention in the public debate - mostly in connection with their potential for biomedical application and therapies. While the promise of organ regeneration and the end of cancer have captured our imagination, it has gone almost unnoticed that plant stem cells represent the ultimate origin of much of the food we eat, the oxygen we breathe, as well the fuels we burn. Thus, plant stem cells may be ranked among the most important cells for human well-being...
September 12, 2016: Current Biology: CB
Michail Sideris, Apostolos Papalois, Korina Theodoraki, Ioannis Dimitropoulos, Elizabeth O Johnson, Efstratia-Maria Georgopoulou, Nikolaos Staikoglou, Georgios Paparoidamis, Panteleimon Pantelidis, Ismini Tsagkaraki, Stefanos Karamaroudis, Michael E Potoupnis, Eleftherios Tsiridis, Panagiotis Dedeilias, Savvas Papagrigoriadis, Vassilios Papalois, Georgios Zografos, Aggeliki Triantafyllou, Georgios Tsoulfas
BACKGROUND: Undergraduate Surgical Education is becoming an essential element in the training of the future generation of safe and efficient surgeons. Essential Skills in the Management of Surgical Cases (ESMSC), is an international, joint applied surgical science and simulation-based learning wet lab course. METHODS: We performed a review of the existing literature on the topic of undergraduate surgical education. Following that, we analyzed the feedback questionnaire received 480 from 2 recent series of ESMSC courses (May 2015, n = 49 and November 2015, n = 40), in order to evaluate European Union students' (UK, Germany, Greece) views on the ESMSC course, as well as on the undergraduate surgical education...
September 9, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Ilias Georgakopoulos-Soares, Naman Jain, Jesse M Gray, Martin Hemberg
MOTIVATION: With the rapid advances in DNA synthesis and sequencing technologies and the continuing decline in the associated costs, high-throughput experiments can be performed to investigate the regulatory role of thousands of oligonucleotide sequences simultaneously. Nevertheless, designing high-throughput reporter assay experiments such as massively parallel reporter assays (MPRAs) and similar methods remains challenging. RESULTS: We introduce MPRAnator, a set of tools that facilitate rapid design of MPRA experiments...
September 6, 2016: Bioinformatics
Djordje Gligorijevic, Jelena Stojanovic, Nemanja Djuric, Vladan Radosavljevic, Mihajlo Grbovic, Rob J Kulathinal, Zoran Obradovic
Data-driven phenotype analyses on Electronic Health Record (EHR) data have recently drawn benefits across many areas of clinical practice, uncovering new links in the medical sciences that can potentially affect the well-being of millions of patients. In this paper, EHR data is used to discover novel relationships between diseases by studying their comorbidities (co-occurrences in patients). A novel embedding model is designed to extract knowledge from disease comorbidities by learning from a large-scale EHR database comprising more than 35 million inpatient cases spanning nearly a decade, revealing significant improvements on disease phenotyping over current computational approaches...
2016: Scientific Reports
Jayan Ozhikandathil, Simona Badilescu, Muthukumaran Packirisamy
Lab-on-chip technology is attracting great interest due to its potential as miniaturized devices that can automate and integrate many sample-handling steps, minimize consumption of reagent and samples, have short processing time and enable multiplexed analysis. Microfluidic devices have demonstrated their potential for a broad range of applications in life sciences, including point-of-care diagnostics and personalized medicine, based on the routine diagnosis of levels of hormones, cancer markers, and various metabolic products in blood, serum, etc...
August 27, 2016: Journal of Neural Transmission
Mitra L Taheri, Eric A Stach, Ilke Arslan, P A Crozier, Bernd C Kabius, Thomas LaGrange, Andrew M Minor, Seiji Takeda, Mihaela Tanase, Jakob B Wagner, Renu Sharma
This review article discusses the current and future possibilities for the application of in situ transmission electron microscopy to reveal synthesis pathways and functional mechanisms in complex and nanoscale materials. The findings of a group of scientists, representing academia, government labs and private sector entities (predominantly commercial vendors) during a workshop, held at the Center for Nanoscale Science and Technology- National Institute of Science and Technology (CNST-NIST), are discussed. We provide a comprehensive review of the scientific needs and future instrument and technique developments required to meet them...
August 6, 2016: Ultramicroscopy
Wiebke Jahr, Benjamin Schmid, Michael Weber, Jan Huisken
LIGHT SHEET MICROSCOPY IN THE MUSEUM: Light sheet microscopy (or selective plane illumination microscopy) is an important imaging technique in the life sciences. At the same time, this technique is also ideally suited for community outreach projects, because it produces visually appealing, highly dynamic images of living organisms and its working principle can be understood with basic optics knowledge. Still, the underlying concepts are widely unknown to the non-scientific public. On the occasion of the UNESCO International Year of Light, a technical museum in Dresden, Germany, launched a special, interactive exhibition...
2016: PloS One
Kabindra M Shakya, Alyssa Noyes, Randa Kallin, Richard E Peltier
Inexpensive cloth masks are widely used in developing countries to protect from particulate pollution albeit limited data on their efficacy exists. This study examined the efficiency of four types of masks (three types of cloth masks and one type of surgical mask) commonly worn in the developing world. Five monodispersed aerosol sphere size (30, 100, and 500 nm, and 1 and 2.5 μm) and diluted whole diesel exhaust was used to assess facemask performance. Among the three cloth mask types, a cloth mask with an exhaust valve performed best with filtration efficiency of 80-90% for the measured polystyrene latex (PSL) particle sizes...
August 17, 2016: Journal of Exposure Science & Environmental Epidemiology
Adil Bata, Ata Ur Rehman Quraishi, Michael Love, Lawrence Title, Hussein Beydoun, Tony Lee, Najaf Nadeem, Bakhtiar Kidwai, Catherine Kells, Helen Curran
BACKGROUND: To determine whether pre-activation of the cardiac catheterization lab by Emergency Health Services (EHS) with a single call system in the field was associated with reduced time to reperfusion in patients with ST-Elevation Myocardial Infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: Consecutive STEMI patients identified by EHS and subsequently taken to the Queen Elizabeth II Health Sciences Center (QEIIHSC) for PPCI between February 1, 2011 and January 30, 2013 were examined...
November 1, 2016: International Journal of Cardiology
Chris N Bayer, Michael Luberda
Incomprehension and denial of the theory of evolution among high school students has been observed to also occur when teachers are not equipped to deliver a compelling case also for human evolution based on fossil evidence. This paper assesses the outcomes of a novel inquiry-based paleoanthropology lab teaching human evolution to high-school students. The inquiry-based Be a Paleoanthropologist for a Day lab placed a dozen hominin skulls into the hands of high-school students. Upon measuring three variables of human evolution, students explain what they have observed and discuss findings...
2016: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"