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https://www.readbyqxmd.com/read/28820754/sleep-apps-what-role-do-they-play-in-clinical-medicine
#1
Christopher P Lorenz, Adrian J Williams
PURPOSE OF REVIEW: Today's smartphones boast more computing power than the Apollo Guidance Computer. Given the ubiquity and popularity of smartphones, are we already carrying around miniaturized sleep labs in our pockets? RECENT FINDINGS: There is still a lack of validation studies for consumer sleep technologies in general and apps for monitoring sleep in particular. To overcome this gap, multidisciplinary teams are needed that focus on feasibility work at the intersection of software engineering, data science and clinical sleep medicine...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28765210/an-interview-with-jim-smith
#2
Aidan Maartens
Jim Smith is Director of Science at the Wellcome Trust and a group leader at the Francis Crick Institute, where he was formerly Director of Research. A Fellow of both the Royal Society and the Academy of Medical Sciences, he was knighted for his services to medical research and science education in 2016. His lab works on mesoderm induction in the early vertebrate embryo. We met Jim in the Crick to hear about his life in science, his visions for the Crick and the Wellcome Trust, and his advice for early career scientists...
August 1, 2017: Development
https://www.readbyqxmd.com/read/28750104/breps-2-0-optimization-of-sequence-pattern-prediction-for-enzyme-annotation
#3
Christian-Alexander Dudek, Henning Dannheim, Dietmar Schomburg
The prediction of gene functions is crucial for a large number of different life science areas. Faster high throughput sequencing techniques generate more and larger datasets. The manual annotation by classical wet-lab experiments is not suitable for these large amounts of data. We showed earlier that the automatic sequence pattern-based BrEPS protocol, based on manually curated sequences, can be used for the prediction of enzymatic functions of genes. The growing sequence databases provide the opportunity for more reliable patterns, but are also a challenge for the implementation of automatic protocols...
2017: PloS One
https://www.readbyqxmd.com/read/28725218/all-new-faces-of-diatoms-potential-source-of-nanomaterials-and-beyond
#4
REVIEW
Meerambika Mishra, Ananta P Arukha, Tufail Bashir, Dhananjay Yadav, G B K S Prasad
Nature's silicon marvel, the diatoms have lately astounded the scientific community with its intricate designs and lasting durability. Diatoms are a major group of phytoplanktons involved in the biogeochemical cycling of silica and are virtually inherent in every environment ranging from water to ice to soil. The usage of diatoms has proved prudently cost effective and its handling neither requires costly materials nor sophisticated instruments. Diatoms can easily be acquired from the environment, their culture requires ambient condition and does not involve any costly media or expensive instruments, besides, they can be transported in small quantities and proliferated to a desirable confluence from that scratch, thus are excellent cost effective industrial raw material...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28719040/discovering-long-term-potentiation-ltp-recollections-and-reflections-on-what-came-after
#5
REVIEW
Terje Lømo
Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's lab in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years...
July 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28687969/impact-of-zika-virus-for-infertility-specialists-current-literature-guidelines-and-resources
#6
REVIEW
Jamie P Dubaut, Nelson I Agudelo Higuita, Alexander M Quaas
In the past 2 years, Zika virus has emerged from obscurity onto the world stage-traversing and transcending clinical specialties, basic science disciplines, and public health efforts. The spread of Zika virus has serious implications for the specialty of reproductive endocrinology and infertility. Our patients, practices, and labs-worldwide and specifically in the USA-have been impacted by this teratogenic, sexually transmitted, largely asymptomatic virus. While the World Health Organization's Public Emergency of International Concern designation has lapsed as major epidemics have subsided and understanding of risks is in part clarified, the acute and long-term threat to pregnant patients is not over...
July 7, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28676565/an-interview-with-bill-harris
#7
Aidan Maartens
William 'Bill' Harris is Head of the Department of Physiology, Development and Neuroscience at the University of Cambridge, UK, and a Fellow of both the Royal Society and Academy of Medical Sciences. His lab works on the development of the vertebrate nervous system, with a particular focus on cell lineage in the retina. In 2017 he was awarded the British Society for Developmental Biology's Waddington Medal for outstanding research performance and services to the community. We met Bill in his Cambridge lab to talk science, art and ice hockey...
July 1, 2017: Development
https://www.readbyqxmd.com/read/28663288/what-your-pi-forgot-to-tell-you-why-you-actually-might-want-a-job-running-a-research-lab
#8
Amy S Gladfelter, Mark Peifer
A PhD in biomedical science and the critical thinking skills that it provides can open the door to many different careers. The current popular scientific press and blogosphere too often portray the job of a research-intensive faculty member and principal investigator (PI) as both unattainable and undesirable. We want to make sure our trainees include our own career path among their options, as for each of us it has been a fantastic, family-friendly, and highly impactful career.
July 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28646401/a-standardized-set-of-3-d-objects-for-virtual-reality-research-and-applications
#9
David Peeters
The use of immersive virtual reality as a research tool is rapidly increasing in numerous scientific disciplines. By combining ecological validity with strict experimental control, immersive virtual reality provides the potential to develop and test scientific theories in rich environments that closely resemble everyday settings. This article introduces the first standardized database of colored three-dimensional (3-D) objects that can be used in virtual reality and augmented reality research and applications...
June 23, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28642491/a-cross-species-approach-to-identify-transcriptional-regulators-exemplified-for-dnajc22-and-hnf4a
#10
A C Aschenbrenner, K Bassler, M Brondolin, L Bonaguro, P Carrera, K Klee, T Ulas, J L Schultze, M Hoch
There is an enormous need to make better use of the ever increasing wealth of publicly available genomic information and to utilize the tremendous progress in computational approaches in the life sciences. Transcriptional regulation of protein-coding genes is a major mechanism of controlling cellular functions. However, the myriad of transcription factors potentially controlling transcription of any given gene makes it often difficult to quickly identify the biological relevant transcription factors. Here, we report on the identification of Hnf4a as a major transcription factor of the so far unstudied DnaJ heat shock protein family (Hsp40) member C22 (Dnajc22)...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28640806/good-enough-practices-in-scientific-computing
#11
Greg Wilson, Jennifer Bryan, Karen Cranston, Justin Kitzes, Lex Nederbragt, Tracy K Teal
Computers are now essential in all branches of science, but most researchers are never taught the equivalent of basic lab skills for research computing. As a result, data can get lost, analyses can take much longer than necessary, and researchers are limited in how effectively they can work with software and data. Computing workflows need to follow the same practices as lab projects and notebooks, with organized data, documented steps, and the project structured for reproducibility, but researchers new to computing often don't know where to start...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28603770/embodied-science-and-mixed-reality-how-gesture-and-motion-capture-affect-physics-education
#12
Mina C Johnson-Glenberg, Colleen Megowan-Romanowicz
A mixed design was created using text and game-like multimedia to instruct in the content of physics. The study assessed which variables predicted learning gains after a 1-h lesson on the electric field. The three manipulated variables were: (1) level of embodiment; (2) level of active generativity; and (3) presence of story narrative. Two types of tests were administered: (1) a traditional text-based physics test answered with a keyboard; and (2) a more embodied, transfer test using the Wacom large tablet where learners could use gestures (long swipes) to create vectors and answers...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28594204/taking-forensic-mental-health-assessment-out-of-the-lab-and-into-the-real-world-introduction-to-the-special-issue-on-the-field-utility-of-forensic-assessment-instruments-and-procedures
#13
John F Edens, Marcus T Boccaccini
The last several decades have seen a major upswing in the development and use of psychological assessment instruments in forensic and correctional settings. At the same time, admissibility standards increasingly have stressed the importance of the reliability and validity of evidence in legal proceedings. Recent research has, however, raised serious concerns about (a) the reliability of forensic science evidence in general, (b) the replicability of psychological research findings in general and in field settings especially, and (c) the interrater reliability and predictive validity of forensic psychological assessment evidence in particular...
June 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28593605/online-webcam-based-eye-tracking-in-cognitive-science-a-first-look
#14
Kilian Semmelmann, Sarah Weigelt
Online experimentation is emerging in many areas of cognitive psychology as a viable alternative or supplement to classical in-lab experimentation. While performance- and reaction-time-based paradigms are covered in recent studies, one instrument of cognitive psychology has not received much attention up to now: eye tracking. In this study, we used JavaScript-based eye tracking algorithms recently made available by Papoutsaki et al. (International Joint Conference on Artificial Intelligence, 2016) together with consumer-grade webcams to investigate the potential of online eye tracking to benefit from the common advantages of online data conduction...
June 7, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28589305/discriminating-ability-of-abbreviated-impactor-measurement-approach-aim-to-detect-changes-in-mass-median-aerodynamic-diameter-mmad-of-an-albuterol-salbutamol-pmdi-aerosol
#15
J David Christopher, Rajni B Patel, Jolyon P Mitchell, Terrence P Tougas, Adrian P Goodey, Jorge Quiroz, Patrik U Andersson, Svetlana Lyapustina
This article reports on results from a two-lab, multiple impactor experiment evaluating the abbreviated impactor measurement (AIM) concept, conducted by the Cascade Impaction Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS). The goal of this experiment was to expand understanding of the performance of an AIM-type apparatus based on the Andersen eight-stage non-viable cascade impactor (ACI) for the assessment of inhalation aerosols and sprays, compared with the full-resolution version of that impactor described in the pharmacopeial compendia...
June 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28588568/food-safety-in-the-age-of-next-generation-sequencing-bioinformatics-and-open-data-access
#16
REVIEW
Eduardo N Taboada, Morag R Graham, João A Carriço, Gary Van Domselaar
Public health labs and food regulatory agencies globally are embracing whole genome sequencing (WGS) as a revolutionary new method that is positioned to replace numerous existing diagnostic and microbial typing technologies with a single new target: the microbial draft genome. The ability to cheaply generate large amounts of microbial genome sequence data, combined with emerging policies of food regulatory and public health institutions making their microbial sequences increasingly available and public, has served to open up the field to the general scientific community...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28577501/advances-in-developing-rapid-reliable-and-portable-detection-systems-for-alcohol
#17
REVIEW
Phurpa Dema Thungon, Ankana Kakoti, Lightson Ngashangva, Pranab Goswami
Development of portable, reliable, sensitive, simple, and inexpensive detection system for alcohol has been an instinctive demand not only in traditional brewing, pharmaceutical, food and clinical industries but also in rapidly growing alcohol based fuel industries. Highly sensitive, selective, and reliable alcohol detections are currently amenable typically through the sophisticated instrument based analyses confined mostly to the state-of-art analytical laboratory facilities. With the growing demand of rapid and reliable alcohol detection systems, an all-round attempt has been made over the past decade encompassing various disciplines from basic and engineering sciences...
May 25, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28575708/education-of-student-nurses-a-systematic-literature-review
#18
REVIEW
Kathrine Håland Jeppesen, Sytter Christiansen, Kirsten Frederiksen
OBJECTIVE: The aim of this review was to explore the literature on the connection between teaching strategies and nursing students' learning to clarify which teaching strategies provide optimal learning experiences and outcomes. DATA SOURCES: Sources dating from January 2000 to November 2016 were systematically searched in PubMed, Cinahl, Scopus, Web of Science, ProQuest. METHODS: A systematic literature review was conducted that included quantitative and qualitative studies...
August 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28572181/how-do-you-like-your-science-wet-or-dry-how-two-lab-experiences-influence-student-understanding-of-science-concepts-and-perceptions-of-authentic-scientific-practice
#19
Maureen Munn, Randy Knuth, Katie Van Horne, Andrew W Shouse, Sheldon Levias
This study examines how two kinds of authentic research experiences related to smoking behavior-genotyping human DNA (wet lab) and using a database to test hypotheses about factors that affect smoking behavior (dry lab)-influence students' perceptions and understanding of scientific research and related science concepts. The study used pre and post surveys and a focus group protocol to compare students who conducted the research experiences in one of two sequences: genotyping before database and database before genotyping...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28559236/an-interview-with-hiroshi-hamada
#20
Katherine Brown
Hiroshi Hamada is the Director of the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan. His lab focusses on the establishment of left-right asymmetry in the mouse embryo, and the role of cilia in the symmetry-breaking event. Hiroshi's work has been recognised by various awards, including the Keio Medical Science Prize in 2014, and election as an EMBO Associate Member in 2016. We met with Hiroshi on a recent visit to the CDB, to talk about his career and current interests, and the prospects for developmental biology in Japan...
June 1, 2017: Development
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