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https://www.readbyqxmd.com/read/29324578/training-volume-not-frequency-indicative-of-maximal-strength-adaptations-to-resistance-training
#1
Ryan J Colquhoun, Christopher M Gai, Danielle Aguilar, Daniel Bove, Jeffrey Dolan, Andres Vargas, Kaylee Couvillion, Nathaniel D M Jenkins, Bill I Campbell
PURPOSE: To compare the effects of a high- versus a moderate-training frequency on maximal strength and body composition. METHODS: 28 young, healthy resistance-trained males were randomly assigned to either: 3x/week (3x; n=16) or 6x/week (6x; n=12). Dependent variables (DVs) assessed at baseline and after the 6-week training intervention included: squat 1RM (SQ1RM), bench press 1RM (BP1RM), deadlift 1RM (DL1RM), powerlifting total (PLT), Wilk's coefficient (WC), fat-free mass (FFM) and fat mass (FM)...
January 5, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29314250/inhibition-of-camkk2-enhances-fracture-healing-by-stimulating-indian-hedgehog-signaling-and-accelerating-endochondral-ossification
#2
Justin N Williams, Anuradha Valiya Kambrath, Roshni B Patel, Kyung Shin Kang, Elsa Mével, Yong Li, Ying-Hua Cheng, Austin J Pucylowski, Mariah A Hassert, Michael J Voor, Melissa A Kacena, William R Thompson, Stuart J Warden, David B Burr, Matthew R Allen, Alexander G Robling, Uma Sankar
Approximately ten percent of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca2+ /calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) reverses age-associated loss of trabecular and cortical bone volume and strength in mice. In the current study, we investigated the role of CaMKK2 in bone fracture healing and show that its pharmacological inhibition using STO-609 accelerates early cellular and molecular events associated with endochondral ossification, resulting in a more rapid and efficient healing of the fracture...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29286514/cardiovascular-diseases-and-systolic-function-of-left-ventricle-in-clean-up-workers-of-chernobyl-accident-based-on-30-years-follow-up
#3
O D Bazyka, D O Belyi
OBJECTIVE: To study the dynamics of circulatory system diseases during the 30 year period after irradiation, changes in the status of systolic function of heart left ventricle (LV) and the features of its remodeling in clean up workers (CW) of the accident at the Chernobyl nuclear power plant (ChNPP). MATERIAL AND METHODS: It was examined 144 CW at ChNPP, including 52 patients, who survived acute radiation sick ness (ARS) grade of severity 1-3, and 105 non irradiated persons (control group - CG)...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29283292/morphological-molecular-and-hormonal-adaptations-to-early-morning-versus-afternoon-resistance-training
#4
Milan Sedliak, Michal Zeman, Gabriel Buzgó, Jan Cvecka, Dusan Hamar, Eugen Laczo, Monika Okuliarova, Marian Vanderka, Tomas Kampmiller, Keijo Häkkinen, Juha P Ahtiainen, Juha J Hulmi, Tormod S Nilsen, Håvard Wiig, Truls Raastad
It has been clearly established that maximal force and power is lower in the morning compared to noon or afternoon hours. This morning neuromuscular deficit can be diminished by regularly training in the morning hours. However, there is limited and contradictory information upon hypertrophic adaptations to time-of-day-specific resistance training. Moreover, no cellular or molecular mechanisms related to muscle hypertrophy adaptation have been studied with this respect. Therefore, the present study examined effects of the time-of-day-specific resistance training on muscle hypertrophy, phosphorylation of selected proteins, hormonal concentrations and neuromuscular performance...
December 28, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29282529/the-development-of-skeletal-muscle-hypertrophy-through-resistance-training-the-role-of-muscle-damage-and-muscle-protein-synthesis
#5
REVIEW
Felipe Damas, Cleiton A Libardi, Carlos Ugrinowitsch
Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process. Despite substantial advances, we are far from understanding exactly how muscle hypertrophy develops during RT. The aim of the present review is to discuss new insights related to the role of skeletal muscle damage and muscle protein synthesis (MPS) in mediating RT-induced hypertrophy. Specifically, the thesis that in the early phase of RT (≤ 4 previous RT sessions) increases in muscle cross-sectional area are mostly attributable to muscle damage-induced muscle swelling; then (after ~ 10 sessions), a modest magnitude of muscle hypertrophy ensues; but only during a latter phase of RT (after ~ 18 sessions) is true muscle hypertrophy observed...
December 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29240948/early-cyclical-neuromuscular-electrical-stimulation-improves-strength-and-trophism-by-akt-pathway-signaling-in-partially-paralyzed-biceps-muscle-after-spinal-cord-injury-in-rats
#6
Gabriel R de Freitas, Caroline C do Espírito Santo, Nicolas A M M de Machado-Pereira, Franciane Bobinski, Adair R S Dos Santos, Jocemar Ilha
Background: Electrical stimulation is often used to treat weakness in people with spinal cord injury (SCI), however its efficacy to increase strength and trophism are weak and the mechanisms underlying the therapeutic benefits are unknown. Objective: The purpose of the study was to analyze the effects of neuromuscular electrical stimulation (NMES) on muscle function, trophism and the Akt pathway signaling involved in muscular plasticity after incomplete-SCI in rats...
December 12, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29229272/effect-of-different-resistance-training-protocols-on-the-extracellular-matrix-of-the-calcaneal-tendon-of-rats
#7
Josete Mazon, Andrea Aparecida de Aro, Priscyla Waleska Targino de Azevedo Simões, Edson Rosa Pimentel
The calcaneal tendon extracellular matrix (ECM) is composed of collagen, non-collagenous glycoproteins and proteoglycans, and able to adapt to various biomechanical stimuli. The objective of this study was to analyze the response of different resistance-training protocols, such as hypertrophy, strength and resistance, on the organization of the calcaneal tendon after training. Wistar rats were divided into for groups: untrained (UT), resistance training (RT), hypertrophy training (HT), and strength training (ST)...
December 8, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29228710/irisin-treatment-improves-healing-of-dystrophic-skeletal-muscle
#8
Musarrat Maisha Reza, Chu Ming Sim, Nathiya Subramaniyam, Xiaojia Ge, Mridula Sharma, Ravi Kambadur, Craig McFarlane
Background: Irisin is an exercise induced myokine that is shown to promote browning of adipose tissue and hence, increase energy expenditure. Furthermore, our unpublished results indicate that Irisin improves myogenic differentiation and induces skeletal muscle hypertrophy. Since exercise induced skeletal muscle hypertrophy improves muscle strength, we wanted to investigate if ectopic injection of Irisin peptide improves skeletal muscle function in a mouse model of muscular dystrophy...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216446/comparison-of-two-equated-resistance-training-weekly-volume-routines-using-different-frequencies-on-body-composition-and-performance-in-trained-males
#9
Yue Fu, Bettina Karsten, Eneko Larumbe-Zabala, Marcos Seijo, Fernando Naclerio
The present study compared the effects of two weekly-equalized volume and relative load interventions on body composition, strength and power. Based on individual baseline maximal strength values, eighteen recreationally trained men were pair-matched and consequently randomly assigned to one of the following experimental groups: a low volume per session with a high frequency (LV-HF, n = 9) group who trained 4-days (Mondays, Tuesdays, Thursdays and Fridays) or a high volume per session and low frequency (HV-LF, n = 9) group who trained 2-days (Mondays and Thursdays)...
December 7, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29214923/creatine-supplementation-elicits-greater-muscle-hypertrophy-in-upper-than-lower-limbs-and-trunk-in-resistance-trained-men
#10
João Pedro Nunes, Alex S Ribeiro, Brad J Schoenfeld, Crisieli M Tomeleri, Ademar Avelar, Michele Cc Trindade, Hellen Cg Nabuco, Edilaine F Cavalcante, Paulo Sugihara Junior, Rodrigo R Fernandes, Ferdinando O Carvalho, Edilson S Cyrino
BACKGROUND: Creatine (Cr) supplementation associated with resistance training produces greater muscular strength improvements in the upper compared with the lower body; however, no study has investigated if such region-specific results are seen with gains in muscle mass. AIM: We aimed to evaluate the effect of Cr supplementation in combination with resistance training on lean soft tissue changes in the upper and lower limbs and trunk in resistance-trained young adult men...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29200983/the-short-term-effect-of-high-versus-moderate-protein-intake-on-recovery-after-strength-training-in-resistance-trained-individuals
#11
Justin Roberts, Anastasia Zinchenko, Craig Suckling, Lee Smith, James Johnstone, Menno Henselmans
Background: Dietary protein intakes up to 2.9 g.kg-1.d-1 and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29188577/benefits-of-resistance-training-in-physically-frail-elderly-a-systematic-review
#12
REVIEW
Pedro Lopez, Ronei Silveira Pinto, Regis Radaelli, Anderson Rech, Rafael Grazioli, Mikel Izquierdo, Eduardo Lusa Cadore
AIM: Exercise is one of the most important components in frailty prevention and treatment. Therefore, we systematically reviewed the effect of resistance training (RT) alone or combined with multimodal exercise intervention on muscle hypertrophy, maximal strength, power output, functional performance, and falls incidence in physically frail elderly. METHODS: MEDLINE, Cochrane CENTRAL, PEDro, and SPORTDiscus databases were searched from 2005 to 2017. Studies must have mentioned the effects of RT (i...
November 29, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29172848/the-role-of-hormones-in-muscle-hypertrophy
#13
Julius Fink, Brad Jon Schoenfeld, Koichi Nakazato
Anabolic-androgenic steroids (AAS) and other hormones such as growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have been shown to increase muscle mass in patients suffering from various diseases related to muscle atrophy. Despite known side-effects associated with supraphysiologic doses of such drugs, their anabolic effects have led to their widespread use and abuse by bodybuilders and athletes such as strength athletes seeking to improve performance and muscle mass. On the other hand, resistance training (RT) has also been shown to induce significant endogenous hormonal (testosterone (T), GH, IGF-1) elevations...
November 25, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29152896/trimetazidine-restores-the-positive-adaptation-to-exercise-training-by-mitigating-statin-induced-skeletal-muscle-injury
#14
Ming Song, Fang-Fang Chen, Yi-Hui Li, Lei Zhang, Feng Wang, Ran-Ran Qin, Zhi-Hao Wang, Ming Zhong, Meng-Xiong Tang, Wei Zhang, Lu Han
BACKGROUND: Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as the key medicine to lower cholesterol in CHD, result in skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction is identified as the potential mechanism underlying statin-induced skeletal muscle injury. In this study, we investigated the effects of the metabolic modulator trimetazidine on skeletal muscle energy metabolism and statin-associated exercise intolerance...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29137022/the-effect-of-whole-body-vibration-training-on-lean-mass-a-prisma-compliant-meta-analysis
#15
Hengting Chen, Jianxiong Ma, Bin Lu, Xin-Long Ma
BACKGROUND: Whole-body vibration training (WBVT) confers a continuous vibration stimuli to the body. Although some reports have discussed the effects of whole-body vibration (WBV) on bone mineral density and muscle strength, study of WBV effects on lean mass have not been determined. The purpose of the present meta-analysis was to evaluate published, randomized controlled trials (RCTs) that investigated the effects of WBVT on lean mass. METHODS: We identified only RCTs by searching databases, including Web of Science, PubMed, Scopus, Embase, and the Cochrane Library from inception to March 2017...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29131444/native-t1-reference-values-for-nonischemic-cardiomyopathies-and-populations-with-increased-cardiovascular-risk-a-systematic-review-and-meta-analysis
#16
REVIEW
Maaike van den Boomen, Riemer H J A Slart, Enzo V Hulleman, Rudi A J O Dierckx, Birgitta K Velthuis, Pim van der Harst, David E Sosnovik, Ronald J H Borra, Niek H J Prakken
BACKGROUND: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. PURPOSE: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. STUDY TYPE: Systemic review and meta-analysis...
November 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29127601/interpreting-adaptation-to-concurrent-compared-with-single-mode-exercise-training-some-methodological-considerations
#17
REVIEW
Jackson J Fyfe, Jeremy P Loenneke
Incorporating both endurance and resistance training into an exercise regime is termed concurrent training. While there is evidence that concurrent training can attenuate resistance training-induced improvements in maximal strength and muscle hypertrophy, research findings are often equivocal, with some suggesting short-term concurrent training may instead further enhance muscle hypertrophy versus resistance training alone. These observations have questioned the validity of the purported 'interference effect' on muscle hypertrophy with concurrent versus single-mode resistance training...
November 10, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29123487/hypertrophy-stimulation-at-the-onset-of-type-i-diabetes-maintains-the-soleus-but-not-the-edl-muscle-mass-in-wistar-rats
#18
Marco A S Fortes, Maria V M Scervino, Gabriel N Marzuca-Nassr, Kaio F Vitzel, Carlos H da Justa Pinheiro, Rui Curi
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The experiments were performed in oxidative (soleus) or glycolytic (EDL) muscles...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29120984/effects-of-different-resistance-training-systems-on-muscular-strength-and-hypertrophy-in-resistance-trained-older-women
#19
Alex S Ribeiro, Andreo F Aguiar, Brad J Schoenfeld, João Pedro Nunes, Edilaine F Cavalcanti, Eduardo L Cadore, Edilson S Cyrino
The purpose of this study was to investigate the effect of resistance training (RT) performed in a pyramid (PR) versus constant (CT) load system on muscular strength and hypertrophy in resistance-trained older women. Thirty-three older women (69.7±5.9 years, 69.1±15.0 kg, 156.6±6.2 cm, and 28.1±5.4 kg.m) were randomized into 2 groups: one that performed RT with a CT load (n = 16) and another group that performed RT in an ascending PR fashion (n = 17). Outcomes included 1 repetition maximum (RM) tests and assessment of skeletal muscle mass estimated by dual energy X-ray absorptiometry...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29120981/biomechanical-methods-to-quantify-muscle-effort-during-resistance-exercise
#20
Loren Z F Chiu
Muscle hypertrophy and strength adaptations elicited by resistance training dependent on the force exerted by active muscles. As an exercise may use many muscles, determining force for individual muscles or muscle groupings is important to understand the relation between an exercise and these adaptations. Muscle effort - the amount of force or a surrogate measure related to the amount of force exerted during a task - can be quantified using biomechanical methods. The purpose of this review was to summarize the biomechanical methods used to estimate muscle effort in movements, particularly resistance training exercises...
November 6, 2017: Journal of Strength and Conditioning Research
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