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https://www.readbyqxmd.com/read/28209124/rna-seq-and-metabolomic-analyses-of-akt1-mediated-muscle-growth-reveals-regulation-of-regenerative-pathways-and-changes-in-the-muscle-secretome
#1
Chia-Ling Wu, Yoshinori Satomi, Kenneth Walsh
BACKGROUND: Skeletal muscle is a major regulator of systemic metabolism as it serves as the major site for glucose disposal and the main reservoir for amino acids. With aging, cachexia, starvation, and myositis, there is a preferential loss of fast glycolytic muscle fibers. We previously reported a mouse model in which a constitutively-active Akt transgene is induced to express in a subset of muscle groups leading to the hypertrophy of type IIb myofibers with an accompanying increase in strength...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28184235/phosphatidic-acid-biosynthesis-pharmacokinetics-mechanisms-of-action-and-effect-on-strength-and-body-composition-in-resistance-trained-individuals
#2
REVIEW
Peter Bond
The mechanistic target of rapamycin complex 1 (mTORC1) has received much attention in the field of exercise physiology as a master regulator of skeletal muscle hypertrophy. The multiprotein complex is regulated by various signals such as growth factors, energy status, amino acids and mechanical stimuli. Importantly, the glycerophospholipid phosphatidic acid (PA) appears to play an important role in mTORC1 activation by mechanical stimulation. PA has been shown to modulate mTOR activity by direct binding to its FKBP12-rapamycin binding domain...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28177706/the-effects-of-acute-branched-chain-amino-acid-supplementation-on-recovery-from-a-single-bout-of-hypertrophy-exercise-in-resistance-trained-athletes
#3
Mark Waldron, Kieran Whelan, Owen Jeffries, Dean Burt, Louis Howe, Stephen David Patterson
This study investigated the effects of acute branched-chain amino acid (BCAA) supplementation on recovery from exercise-induced muscle damage, among experienced resistance-trained athletes. In a double-blind matched-pairs design, 16 resistance-trained participants, routinely performing hypertrophy training, were randomly assigned to a BCAA (n = 8) or placebo (n = 8) group. The BCAAs were administered at a dosage of 0.087 g/kg body mass, with a 2:1:1 ratio of leucine, isoleucine and valine. The participants performed 6 sets of 10 full-squats at 70 % 1RM to induce muscle damage...
January 27, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28159816/implications-of-blood-pressure-measurement-technique-for-implementation-of-systolic-blood-pressure-intervention-trial-sprint
#4
Rajiv Agarwal
BACKGROUND: Cardiovascular morbidity and mortality was reduced by 25% when blood pressure (BP) was targeted to 120 mm Hg systolic compared with 140 mm Hg systolic in Systolic Blood Pressure Intervention Trial (SPRINT); however, BP was measured using a research technique. SPRINT specified 5 minutes of seated rest in a quiet room followed by 3 oscillometric measurements without an observer in the room. The relationship of this research-grade methodology to routine BP measurements is not known...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28149414/neuroendocrine-responses-and-body-composition-changes-following-resistance-training-under-normobaric-hypoxia
#5
Jakub Chycki, Miłośz Czuba, Artur Gołaś, Adam Zając, Olga Fidos-Czuba, Adrian Młynarz, Wojciech Smółka
The aim of the present study was to evaluate the effects of a 6 week resistance training protocol under hypoxic conditions (FiO2 = 12.9%, 4000 m) on muscle hypertrophy. The project included 12 resistance trained male subjects, randomly divided into two experimental groups. Group 1 (n = 6; age 21 ± 2.4 years; body height [BH] 178.8 ± 7.3 cm; body mass [BM] 80.6 ± 12.3 kg) and group 2 (n = 6; age 22 ± 1.5 years; BH 177.8 ± 3.7cm; BM 81.1 ± 7.5 kg). Each group performed resistance exercises alternately under normoxic and hypoxic conditions (4000 m) for 6 weeks...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28130627/crescent-pyramid-and-drop-set-systems-do-not-promote-greater-strength-gains-muscle-hypertrophy-and-changes-on-muscle-architecture-compared-with-traditional-resistance-training-in-well-trained-men
#6
Vitor Angleri, Carlos Ugrinowitsch, Cleiton Augusto Libardi
PURPOSE: The aim of this study was to compare the effects of crescent pyramid (CP) and drop-set (DS) systems with traditional resistance training (TRAD) with equalized total training volume (TTV) on maximum dynamic strength (1-RM), muscle cross-sectional area (CSA), pennation angle (PA), and fascicle length (FL). METHODS: Thirty-two volunteers had their legs randomized in a within-subject design in TRAD (3-5 sets of 6-12 repetitions at 75% 1-RM), CP (3-5 sets of 6-15 repetitions at 65-85% 1-RM), and DS (3-5 sets of ~50-75% 1-RM to muscle failure) protocols...
January 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28119100/antiosteoporotic-effect-of-hemidesmus-indicus-linn-on-ovariectomised-rats
#7
Sharad Desai, Parth Babaria, Madhavi Nakarani, Kunal Shah, Archana Paranjape
PHARMACOLOGICAL RELEVANCE: Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions. AIM OF THE STUDY: Lack of scientific data for potential use in bone loss, the present study was undertaken to investigate the effects of ethanol extract of Hemidesmus indicus root for osteoporosis in ovariectomised rats. MATERIALS AND METHODS: Thirty wistar female rats were randomly divided into five groups...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28118310/ratings-of-perceived-exertion-during-acute-resistance-exercise-performed-at-imposed-and-self-selected-loads-in-recreationally-trained-women
#8
Joshua A Cotter, Matthew J Garver, Taylor K Dinyer, Ciaran M Fairman, Brian C Focht
Resistance exercise (RE) is commonly employed to elicit skeletal muscle adaptation. Relative intensity of a training load links closely with the outcomes of regular RE. This study examined the RPE responses to acute bouts of RE using imposed (40% and 70% of 1RM) and self-selected loads (SS) in recreationally trained women. Twenty physically active women (23.15 ±2.92 yrs.) who reported regular RE training of at least three weekly sessions for the past year, volunteered to participate. During the initial visit, participants completed one repetition maximum (1RM) testing on four exercises in the following order: leg extension, chest press, leg curl, and lat pull-down...
January 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28118308/delayed-onset-muscle-soreness-and-perceived-exertion-following-blood-flow-restriction-exercise
#9
Christopher R Brandner, Stuart A Warmington
The purpose of this study was to determine the perceptual responses to resistance exercise with either heavy-loads (80% 1 repetition maximum [1-RM]), light-loads (20% 1-RM), or light-loads in combination with blood flow restriction (BFR). Despite the use of light-loads, it has been suggested that the adoption of BFR resistance exercise may be limited due to increases in delayed onset muscle soreness (DOMS) and perceived exertion. Seventeen healthy untrained males participated in this balanced, randomized cross-over study...
January 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28109285/korean-mistletoe-viscum-album-coloratum-extract-regulates-gene-expression-related-to-muscle-atrophy-and-muscle-hypertrophy
#10
Juseong Jeong, Choon-Ho Park, Inbo Kim, Young-Ho Kim, Jae-Min Yoon, Kwang-Soo Kim, Jong-Bae Kim
BACKGROUND: Korean mistletoe (Viscum album coloratum) is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions, being implicated in having anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. Recently, we also reported that Korean mistletoe extract (KME) improves endurance exercise in mice, suggesting its beneficial roles in enhancing the capacity of skeletal muscle. METHODS: We examined the expression pattern of several genes concerned with muscle physiology in C2C12 myotubes cells to identify whether KME inhibits muscle atrophy or promotes muscle hypertrophy...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28072800/modified-percutaneous-lumbar-foraminoplasty-and-percutaneous-endoscopic-lumbar-discectomy-instrument-design-technique-notes-and-5-years-follow-up
#11
Zhen-Zhou Li, Shu-Xun Hou, Wei-Lin Shang, Ke-Ran Song, Hong-Liang Zhao
BACKGROUND: Conventional percutaneous endoscopic lumbar discectomy (PELD) with an "inside-outside" technique has 4.3% - 10.3% surgical failure rate, especially in central herniated discs (HDs), migrated HDs, and axillary type HDs. PELD with foraminoplasty has been used for complex HDs. Percutaneous lumbar foraminoplasty (PLF), which is performed with a trephine or bone reamer introduced over a guidewire without a protective working cannula in the original Tessys technique, can quickly cut the hypertrophied bony structure under fluoroscopic guidance, and risk injury to the exiting and traversing nerve roots...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28070459/pre-versus-post-exercise-protein-intake-has-similar-effects-on-muscular-adaptations
#12
Brad Jon Schoenfeld, Alan Aragon, Colin Wilborn, Stacie L Urbina, Sara E Hayward, James Krieger
The purpose of this study was to test the anabolic window theory by investigating muscle strength, hypertrophy, and body composition changes in response to an equal dose of protein consumed either immediately pre- versus post-resistance training (RT) in trained men. Subjects were 21 resistance-trained men (>1 year RT experience) recruited from a university population. After baseline testing, participants were randomly assigned to 1 of 2 experimental groups: a group that consumed a supplement containing 25 g protein and 1 g carbohydrate immediately prior to exercise (PRE-SUPP) (n = 9) or a group that consumed the same supplement immediately post-exercise (POST-SUPP) (n = 12)...
2017: PeerJ
https://www.readbyqxmd.com/read/28032435/effects-of-rest-intervals-and-training-loads-on-metabolic-stress-and-muscle-hypertrophy
#13
Julius Fink, Naoki Kikuchi, Koichi Nakazato
We investigated the effects of volume-matched resistance training (RT) with different training loads and rest intervals on acute responses and long-term muscle and strength gains. Ten subjects trained with short rest (30 s) combined with low load (20 RM) (SL) and ten subjects performed the same protocol with long rest (3 min) and high load (8 RM) (LH). Cross-sectional area (CSA) of the upper arm was measured by magnetic resonance imaging before and after 8 weeks of training. Acute stress markers such as growth hormone (GH) and muscle thickness (MT) changes have been assessed pre and post a single RT session...
December 28, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28005702/time-to-the-peak-of-the-aortic-forward-wave-determines-the-impact-of-aortic-backward-wave-and-pulse-pressure-on-left-ventricular-mass
#14
Grace Tade, Gavin R Norton, Hendrik L Booysen, Moekanyi J Sibiya, Imraan Ballim, Pinhas Sareli, Elena Libhaber, Olebogeng H I Majane, Angela J Woodiwiss
AIM: To determine the degree to which an extended time to the peak of the aortic forward wave or early wave reflection time enhance associations between aortic backward wave pressure and hence central aortic pulse pressure (PPc) and left ventricular mass index (LVMI). METHODS: In 701 adult participants from a community sample either receiving no antihypertensive therapy or receiving low-dose thiazide diuretic monotherapy for at least a year (the major therapy employed), we assessed aortic haemodynamics (SphygmoCor software and wave separation analysis; AtCor Medical, West Ryder, New South Wales, Australia) and LVMI (echocardiography)...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28005636/exercise-induced-hormone-elevations-are-related-to-muscle-growth
#15
Gerald T Mangine, Jay R Hoffman, Adam M Gonzalez, Jeremy R Townsend, Adam J Wells, Adam R Jajtner, Kyle S Beyer, Carleigh H Boone, Ran Wang, Amelia A Miramonti, Michael B LaMonica, David H Fukuda, E Lea Witta, Nicholas A Ratamess, Jeffrey R Stout
Mangine, GT, Hoffman, JR, Gonzalez, AM, Townsend, JR, Wells, AJ, Jajtner, AR, Beyer, KS, Boone, CH, Wang, R, Miramonti, AA, LaMonica, MB, Fukuda, DH, Witta, EL, Ratamess, NA, and Stout, JR. Exercise-induced hormone elevations are related to muscle growth. J Strength Cond Res 31(1): 45-53, 2017-Partial least squares regression structural equation modeling (PLS-SEM) was used to examine relationships between the endocrine response to resistance exercise and muscle hypertrophy in resistance-trained men. Pretesting (PRE) measures of muscle size (thickness and cross-sectional area) of the vastus lateralis and rectus femoris were collected in 26 resistance-trained men...
January 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27984843/acute-and-long-term-responses-to-different-rest-intervals-in-low-load-resistance-training
#16
Julius Etienne Fink, Brad Jon Schoenfeld, Naoki Kikuchi, Koichi Nakazato
We investigated the effects of low-load resistance training to failure performed with different rest intervals on acute hormonal responses and long-term muscle and strength gains. In the acute study, 14 participants were assigned to either a short rest (S, 30 s) or long rest (L, 150 s) protocol at 40% one-repetition maximum. Blood samples were taken before and after the workout. Both groups showed significant (p<0.05) increases in growth hormone and insulin-like growth factor 1 immediately post-workout...
February 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27982685/responses-of-skeletal-muscle-hypertrophy-in-wistar-rats-to-different-resistance-exercise-models
#17
T F Luciano, S de Oliveira Marques, B L da Silva Pieri, D Roxo de Souza, L V Araújo, R T Nesi, D da Luz Scheffer, V H Comin, R A Pinho, A P Muller, C T de Souza
This study aimed to compare the effects of three different resistance exercise models on the quadriceps muscle cross-sectional area, as well as on mTOR phosphorylation and other pivotal molecules involved in the upstream regulation of mTOR. Twenty-four male Wistar rats were divided into untrained (control), endurance resistance training, strength resistance training, and hypertrophy resistance training (HRT) groups (n = 6). After 12 weeks of training, the red portion of the quadriceps was removed for histological and western blot analyses...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27956698/blockade-of-metallothioneins-1-and-2-increases-skeletal-muscle-mass-and-strength
#18
Serge Summermatter, Anais Bouzan, Eliane Pierrel, Stefan Melly, Daniela Stauffer, Sabine Gutzwiller, Erin Nolin, Christina Dornelas, Christy Fryer, Juliet Leighton-Davies, David J Glass, Brigitte Fournier
Metallothioneins are proteins that are involved in intracellular zinc storage and transport. Their expression levels have been reported to be elevated in several settings of skeletal muscle atrophy. We therefore investigated the effect of metallothionein blockade on skeletal muscle anabolism in vitro and in vivo, and found that concomitant abrogation of Metallothionein 1 and 2 results in: activation of the Akt pathway, an increase in myotube size, in type IIb fiber hypertrophy, and ultimately in muscle strength...
December 12, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27941492/effects-of-a-modified-german-volume-training-program-on-muscular-hypertrophy-and-strength
#19
Theban Amirthalingam, Yorgi Mavros, Guy C Wilson, Jillian L Clarke, Lachlan Mitchell, Daniel A Hackett
German Volume Training (GVT), or the 10 sets method, has been used for decades by weightlifters to increase muscle mass. To date, no study has directly examined the training adaptations following GVT. The purpose of this study was to investigate the effect of a modified GVT intervention on muscular hypertrophy and strength. Nineteen healthy males were randomly assign to 6 weeks of 10 or 5 sets of 10 repetitions for specific compound resistance exercises included in a split-routine performed 3 times per week...
November 25, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27928218/differential-effects-of-heavy-versus-moderate-loads-on-measures-of-strength-and-hypertrophy-in-resistance-trained-men
#20
Brad J Schoenfeld, Bret Contreras, Andrew D Vigotsky, Mark Peterson
The purpose of the present study was to evaluate muscular adaptations between heavy- and moderate-load resistance training (RT) with all other variables controlled between conditions. Nineteen resistance-trained men were randomly assigned to either a strength-type RT routine (HEAVY) that trained in a loading range of 2-4 repetitions per set (n = 10) or a hypertrophy-type RT routine (MODERATE) that trained in a loading range of 8-12 repetitions per set (n = 9). Training was carried out 3 days a week for 8 weeks...
December 2016: Journal of Sports Science & Medicine
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