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Ranalozine for neuropathic pain

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https://www.readbyqxmd.com/read/20529343/effects-of-ranolazine-on-wild-type-and-mutant-hnav1-7-channels-and-on-drg-neuron-excitability
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Mark Estacion, Stephen G Waxman, Sulayman D Dib-Hajj
BACKGROUND: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Nav1.7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutations causing congenital indifference to pain. Expression of sodium channel Nav1.8 in DRG neurons has also been shown to be essential for the manifestation of mutant Nav1.7-induced neuronal hyperexcitability...
2010: Molecular Pain
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