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JOURNAL ARTICLE
Feng Pan, Mengyuan Liu, Guanghui Li, Boqian Chen, Yuxiu Chu, Yang Yang, Ercan Wu, Yifei Yu, Shiqi Lin, Tianhao Ding, Xiaoli Wei, Changyou Zhan, Jun Qian
Over the years, there has been significant interest in PEGylated lipid-based nanocarriers within the drug delivery field. The inevitable interplay between the nanocarriers and plasma protein plays a pivotal role in their in vivo biological fate. Understanding the factors influencing lipid-based nanocarrier and protein corona interactions is of paramount importance in the design and clinical translation of these nanocarriers. Herein, discoid-shaped lipid nanodiscs (sNDs) composed of different phospholipids with varied lipid tails and head groups were fabricated...
April 12, 2024: Molecular Pharmaceutics
#22
JOURNAL ARTICLE
Octavia-Andreea Ciora, Tanja Seegmüller, Johannes S Fischer, Theresa Wirth, Friederike Häfner, Sophia Stoecklein, Andreas W Flemmer, Kai Förster, Alida Kindt, Dirk Bassler, Christian F Poets, Narges Ahmidi, Anne Hilgendorff
BACKGROUND: Long-term survival after premature birth is significantly determined by development of morbidities, primarily affecting the cardio-respiratory or central nervous system. Existing studies are limited to pairwise morbidity associations, thereby lacking a holistic understanding of morbidity co-occurrence and respective risk profiles. METHODS: Our study, for the first time, aimed at delineating and characterizing morbidity profiles at near-term age and investigated the most prevalent morbidities in preterm infants: bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), mild cardiac defects, perinatal brain pathology and retinopathy of prematurity (ROP)...
April 11, 2024: BMC Pediatrics
#23
JOURNAL ARTICLE
Seungkuk Ahn, Akanksha Jain, Krishna Chaitanya Kasuba, Makiko Seimiya, Ryoko Okamoto, Barbara Treutlein, Daniel J Müller
Cells assemble fibronectin, the major extracellular matrix (ECM) protein, into fibrillar matrices, which serve as 3D architectural scaffolds to provide, together with other ECM proteins tissue-specific environments. Although recent approaches enable to bioengineer 3D fibrillar fibronectin matrices in vitro, it remains elusive how fibronectin can be co-assembled with other ECM proteins into complex 3D fibrillar matrices that recapitulate tissue-specific compositions and cellular responses. Here, we introduce the engineering of fibrillar fibronectin-templated 3D matrices that can be complemented with other ECM proteins, including vitronectin, collagen, and laminin to resemble ECM architectures observed in vivo...
April 1, 2024: Biomaterials
#24
JOURNAL ARTICLE
Chien-Chih Wang, Tsung-Ming Hu, Yung-Jie Lin, Chien-Lung Chen, Yu-Chuan Hsu, Chung-Lan Kao
Neurorehabilitation devices and technologies are crucial for enhancing stroke recovery. These include noninvasive brain stimulation devices that provide repetitive transcranial magnetic stimulation or transcranial direct current stimulation, which can remodulate an injured brain. Technologies such as robotics, virtual reality, and telerehabilitation are suitable add-ons or complements to physical therapy. However, the appropriate application of these devices and technologies, which target specific deficits and stages, for stroke therapy must be clarified...
April 2024: Journal of International Medical Research
#25
JOURNAL ARTICLE
Dominique Endres, Katharina von Zedtwitz, Kathrin Nickel, Kimon Runge, Alexander Maier, Katharina Domschke, Ulrich Salzer, Harald Prüss, Nils Venhoff, Ludger Tebartz van Elst
INTRODUCTION: Psychotic syndromes can have autoimmune-mediated causes in some patients. Thus, this retrospective work aims to investigate the role of rheumatological markers in the development of psychosis. PATIENTS AND METHODS: In total, 224 patients with psychotic syndromes receiving a "rheumatological laboratory screening" (including C-reactive protein [CRP], immunofixation, complement factors, rheumatoid factor [RF], antiphospholipid antibodies [APAs], antineutrophil cytoplasmic antibodies [ANCAs], and antinuclear antibodies [ANAs]) were analyzed...
April 8, 2024: Brain, Behavior, and Immunity
#26
JOURNAL ARTICLE
Shihao Huang, Shisheng Hao, Yue Si, Dan Shen, Lan Cui, Yuandong Zhang, Hang Lin, Sanwang Wang, Yujun Gao, Xin Guo
Major Depressive Disorder (MDD) is a widespread psychiatric condition that affects a significant portion of the global population. The classification and diagnosis of MDD is crucial for effective treatment. Traditional methods, based on clinical assessment, are subjective and rely on healthcare professionals' expertise. Recently, there's growing interest in using Resting-State Functional Magnetic Resonance Imaging (rs-fMRI) to objectively understand MDD's neurobiology, complementing traditional diagnostics...
April 8, 2024: Journal of Affective Disorders
#27
JOURNAL ARTICLE
Markus Bauswein, Saida Zoubaa, Martina Toelge, Lisa Eidenschink, Markus J Riemenschneider, Bernhard Neumann, De-Hyung Lee, Ehab Eid, Dennis Tappe, Hans Helmut Niller, André Gessner, Barbara Schmidt, Sigrid Bülow, Klemens Angstwurm
BACKGROUND: Borna disease virus 1 (BoDV-1) causes rare but severe zoonotic infections in humans, presenting as severe encephalitis. The case-fatality risk is very high and no effective countermeasures have been established so far. An immunopathology is presumed, while data on immune responses in humans are limited. Evidence of a role of the complement system in various neurological disorders and central nervous viral infections is increasing and specific inhibitors are available as therapeutic options...
April 9, 2024: Journal of Infectious Diseases
#28
JOURNAL ARTICLE
Xinhui Li, Zhongsong Xiao, Peizheng Li, Wensong Yang, Yiqing Shen, Fangyu Liu, Xin Xiong, Qingyuan Wu, Peng Wang, Ruozhi Dang, Siwen Gui, Lan Deng, Anatol Manaenko, Peng Xie, Qi Li
The risk factors and causes of intracerebral hemorrhage (ICH) and the degree of functional recovery after ICH are distinct between young and elderly patients. The increasing incidence of ICH in young adults has become a concern; however, research on the molecules and pathways involved ICH in subjects of different ages is lacking. In this study, tandem mass tag (TMT)-based proteomics was utilized to examine the protein expression profiles of perihematomal tissue from young and aged mice 24 h after collagenase-induced ICH...
2024: Experimental Biology and Medicine
#29
JOURNAL ARTICLE
Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K Sidhu, Stephanie Ascough, Shona C Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Matthew Thorpe, A A Roger Thompson, Sarah L Rowland-Jones, Annemarie B Docherty, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S Howard, Daniel G Wootton, Jennifer K Quint, Thushan I de Silva, Antonia Ho, Christopher Chiu, Ewen M Harrison, William Greenhalf, J Kenneth Baillie, Malcolm G Semple, Lance Turtle, Rachael A Evans, Louise V Wain, Christopher Brightling, Ryan S Thwaites, Peter J M Openshaw
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment...
April 2024: Nature Immunology
#30
JOURNAL ARTICLE
Haruki Koike
Recent advances in genetic and antibody testing have limited pathological examination of peripheral nerve specimens. However, when examining peripheral neuropathological findings from a modern perspective, there is often an opportunity to comprehend previously unnoticed observations upon re-examining the same specimen. For example, electron microscopy studies have suggested that the components that distinguish between nodal regions and internodes play a pivotal role in the behavior of macrophages that initiate myelin phagocytosis in the demyelinating form of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP)...
April 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
#31
Julia L Bachman, Siân R Kitcher, Lucas G Vattino, Holly J Beaulac, M Grace Chaves, Israel Hernandez Rivera, Eleonora Katz, Carolina Wedemeyer, Catherine J C Weisz
UNLABELLED: Cochlear outer hair cells (OHCs) are electromotile and are implicated in mechanisms of amplification of responses to sound that enhance sound sensitivity and frequency tuning. They send information to the brain through glutamatergic synapses onto a small subpopulation of neurons of the ascending auditory nerve, the type II spiral ganglion neurons (SGNs). The OHC synapses onto type II SGNs are sparse and weak, suggesting that type II SGNs respond primarily to loud and possibly damaging levels of sound...
March 31, 2024: bioRxiv
#32
Liam P Hallada, Abbas Shirinifard, David J Solecki
Sorting maturing neurons into distinct layers is critical for brain development, with disruptions leading to neurological disorders and pediatric cancers. Lamination coordinates where, when, and how cells interact, facilitating events that direct migrating neurons to their destined positions within emerging neural networks and control the wiring of connections in functional circuits. While the role of adhesion molecule expression and presentation in driving adhesive recognition during neuronal migration along glial fibers is recognized, the mechanisms by which the spatial arrangement of these molecules on the cell surface dictates adhesive specificity and translates contact-based external cues into intracellular responses like polarization and cytoskeletal organization remain largely unexplored...
March 29, 2024: bioRxiv
#33
JOURNAL ARTICLE
Antonia Klein, Sarah A Aeschlimann, Frederic Zubler, Adrian Scutelnic, Franz Riederer, Matthias Ertl, Christoph J Schankin
BACKGROUND: Visual snow syndrome is a disorder characterized by the combination of typical perceptual disturbances. The clinical picture suggests an impairment of visual filtering mechanisms and might involve primary and secondary visual brain areas, as well as higher-order attentional networks. On the level of cortical oscillations, the alpha rhythm is a prominent EEG pattern that is involved in the prioritisation of visual information. It can be regarded as a correlate of inhibitory modulation within the visual network...
April 8, 2024: Journal of Headache and Pain
#34
JOURNAL ARTICLE
Chaoran Wu, Shiwen Zhang, Hao Sun, Ao Li, Fengsheng Hou, Long Qi, Hong Liao
Ischemic stroke is the leading cause of adult disability. Ischemia leads to progressive neuronal death and synapse loss. The engulfment of stressed synapses by microglia further contributes to the disruption of the surviving neuronal network and related brain function. Unfortunately, there is currently no effective target for suppressing the microglia-mediated synapse engulfment. Stimulator of interferon genes (STING) is an important participant in innate immune response. In the brain, microglia are the primary cell type that mediate immune response after brain insult...
April 8, 2024: Journal of Neuroinflammation
#35
JOURNAL ARTICLE
Xiao Liu, Ying Cao, Xiao Wan Lin, Dan Yang Gao, Hui Hui Miao, Tian Zuo Li
OBJECTIVE: Postoperative delirium (POD) has become a critical challenge with severe consequences and increased incidences as the global population ages. However, the underlying mechanism is yet unknown. Our study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive biomarkers. METHODS: Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control group...
February 20, 2024: Biomedical and Environmental Sciences: BES
#36
JOURNAL ARTICLE
D A Gonzalez, J H Peel, T Pagadala, D G McHail, J R Cressman, T C Dumas
Spatial navigation through novel spaces and to known goal locations recruits multiple integrated structures in the mammalian brain. Within this extended network, the hippocampus enables formation and retrieval of cognitive spatial maps and contributes to decision making at choice points. Exploration and navigation to known goal locations produce synchronous activity of hippocampal neurons resulting in rhythmic oscillation events in local networks. Power of specific oscillatory frequencies and numbers of these events recorded in local field potentials correlate with distinct cognitive aspects of spatial navigation...
April 6, 2024: Journal of Computational Neuroscience
#37
JOURNAL ARTICLE
Maiko Uesaki, Michele Furlan, Andrew T Smith, Hiromasa Takemura
Human cingulate sulcus visual area (CSv) was first identified as an area that responds selectively to visual stimulation indicative of self-motion. It was later shown that the area is also sensitive to vestibular stimulation as well as to bodily motion compatible with locomotion. Understanding the anatomical connections of CSv will shed light on how CSv interacts with other parts of the brain to perform information processing related to self-motion and navigation. A previous neuroimaging study (Smith et al...
2024: PloS One
#38
REVIEW
Zahra Anas, Syeda Fatima Saba Hasan, Muhammad Abdul Moiz, Muhammad Abdul Wasay Zuberi, Hussain Haider Shah, Aima Ejaz, Tirth Dave, Muhammad Hasnain Panjwani, Sameer Abdul Rauf, Muhammad Sheheryar Hussain, Radeyah Waseem
Conventional therapeutic techniques for brain tumours have limitations and side effects, necessitating the need for alternative treatment options. MRI-monitored therapeutic hydrogel systems show potential as a non-surgical approach for brain tumour treatment. Hydrogels have unique physical and chemical properties that make them promising for brain tumour treatment, including the ability to encapsulate therapeutic agents, provide sustained and controlled drug release, and overcome the blood-brain barrier for better penetration...
April 2024: Annals of Medicine and Surgery
#39
JOURNAL ARTICLE
Nathan Chang, Lauren Louderback, Heather Hammett, Kara Hildebrandt, Erica Prendergast, Amelia Sperber, May Casazza, Megan Landess, Aubree Little, Lindsey Rasmussen
BACKGROUND: Nurses are vital partners in the development of pediatric neurocritical care (PNCC) programs. Nursing expertise is acknowledged to be an integral component of high-quality specialty patient care in the field, but little guidance exists regarding educational requirements to build that expertise. We sought to obtain expert consensus from nursing professionals and physicians on curricular priorities for specialized PNCC nursing education in pediatric centers across the United States...
April 3, 2024: Neurocritical Care
#40
JOURNAL ARTICLE
Mohamadreza Asadie, Ali Miri, Taleb Badri, Javad Hosseini Nejad, Javad Gharechahi
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory and cognitive impairment, often accompanied by alterations in mood, confusion, and, ultimately, a state of acute mental disturbance. The cerebral cortex is considered a promising area for investigating the underlying causes of AD by analyzing transcriptional patterns, which could be complemented by investigating blood samples obtained from patients. We analyzed the RNA expression profiles of three distinct areas of the brain cortex, including the frontal cortex (FC), temporal cortex (TC), and entorhinal cortex (EC) in patients with AD...
April 3, 2024: Journal of Molecular Neuroscience: MN
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