Thibaut d'Izarny-Gargas, Pierre Isnard, Idris Boudhabhay, David Buob, Anissa Moktefi, Charel Linster, Aurélie Hummel, Emmanuel Esteve, Vincent Audard, Hélène Lazareth, Nadine Maroun, Alexandre Hertig, Clément Gosset, Charlotte Jouzel, Sarah Permal, Camille Domenger, Olivier Kosmider, Marion Rabant, Alexandre Karras, Jean-Paul Duong-Van-Huyen
A high prevalence of chronic kidney disease (CKD) occurs in patients with myeloproliferative neoplasms (MPN). However, MPN-related glomerulopathy (MPN-RG) may not account for the entirety of CKD risk in this population. The systemic vasculopathy encountered in these patients raises the hypothesis that vascular nephrosclerosis may be a common pattern of injury in patients with MPN and with CKD. In an exhaustive, retrospective, multicenter study of MPN kidney biopsies in four different pathology departments, we now describe glomerular and vascular lesions and establish clinicopathologic correlations...
September 26, 2023: Kidney International