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Mar Llamas-Velasco, Victoria Alegría, Ángel Santos-Briz, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material...
October 18, 2016: American Journal of Dermatopathology
Noëlle Weingertner, Mona Mitcov, Marie-Pierre Chenard, Bernard Cribier
INTRODUCTION: We describe the case of a patient presenting with drug rash with eosinophilia and systemic symptoms (DRESS), where cutaneous biopsy revealed intravascular atypical lymphocytes suggestive of lymphoma. Case report A 77-year-old man was treated with antibiotics for a hip prosthesis infection. Eight weeks later, he developed a maculo-papulous eruption, edema of the extremities, fever and blood eosinophilia. Cutaneous biopsy revealed an atypical T-cell proliferation into the dermal lymphatic vessels...
July 19, 2016: Journal of Cutaneous Pathology
María Teresa Fernández-Figueras, María Teresa Martín-Urdà, Adrià Plana, Octavi Servitje, Rosa María Penin, Gustavo Tapia, José Luis Mate, Aurelio Ariza
AIMS: Many types of intravascular lymphohistiocytic proliferation have been lately described. This was an unnoticed or misinterpreted phenomenon, until recently. Intralymphatic lymphohistiocytic aggregates are relatively common and include benign, malignant, and indeterminate conditions. In contrast, all non-endothelial proliferations in the lumina of blood vessels have been interpreted as malignant so far. Herein, we present three cases of histiocytic proliferations in the lumen of blood vessels associate to extensive hemophagocytosis a previously undescribed entity...
July 5, 2016: Histopathology
Michael Michal, Dmitry V Kazakov, Pavel Dundr, Kvetoslava Peckova, Abbas Agaimy, Heinz Kutzner, Frantisek Havlicek, Ondřej Daum, Magdalena Dubova, Michal Michal
We report 50 cases of peculiar histiocytic proliferations occurring in diverse body sites that currently bear various names, including nodular mesothelial/histiocytic hyperplasia, nodular histiocytic aggregates, mesothelial/monocytic incidental cardiac excrescences, reactive eosinophilic pleuritis, histioeosinophilic granuloma of the thymus, and intralymphatic histiocytosis. They can sometimes cause considerable differential diagnostic difficulties by resembling a metastatic carcinoma or Langerhans cell histiocytosis...
June 23, 2016: American Journal of Surgical Pathology
Kristine M Cornejo, Ediz F Cosar, Patrick OʼDonnell
No abstract text is available yet for this article.
July 2016: American Journal of Dermatopathology
Olivia Larsson, Laila Hellkvist, Ulla Peterson-Westin, Lars Olaf Cardell
INTRODUCTION: Allergic rhinitis (AR) affects over 20% of the population of Europe and the United States. Allergen immunotherapy (AIT) is currently the only form of treatment that affects symptoms and modifies the progression of disease. Established forms of AIT include subcutaneous (SCIT) and sublingual (SLIT) immunotherapy and are widely effective, yet only 2-9% of eligible patients undergo therapy, likely due to the long duration of treatment. As a result, novel, faster forms of AIT are currently under development...
September 2016: Expert Opinion on Biological Therapy
Noriki Fujimoto, Gen Nakanishi, Toshiaki Manabe, Taku Fujimura, Toshihiro Tanaka
Intralymphatic histiocytosis represents a rare reactive disorder, which is characterized by the accumulation of macrophages within lymphatic vessels and observed predominantly in upper extremities. The infiltration and preferential M2 differentiation of macrophage are observed in chronic lymphedema, and lymphedema is considered a causative factor of intralymphatic histiocytosis. However, what causes accumulation of histiocytes in the lymphatic vessels remains unclear, and investigation regarding the characteristics of the macrophages has not been evaluated...
October 2016: Journal of Cutaneous Pathology
S N Freiberger, M Zehnder, G Gafvelin, H Grönlund, T M Kündig, P Johansen
Allergy immunotherapy (AIT) mediates protection against allergen exposure in part due to allergen-specific antibodies. While immunization typically stimulated IgG1 and IgG2, AIT is often associated with production of IgG4. Here, twenty cat dander-sensitized patients were randomized to receive three injections of intralymphatic immunotherapy (ILIT) with MAT-Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo) in a double-blind setting ( NCT00718679). Whereas the clinical data, showing benefit of Mat-Feld1 ILIT was published in 2012 (Senti et al...
September 2016: Allergy
Johannes Martin Schmid, Homaira Nezam, Hans Henrik Torp Madsen, Alexander Schmitz, Hans Jürgen Hoffmann
BACKGROUND: Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment could be performed. Effect of treatment was assessed as change in symptom medication score, response in skin prick test and nasal allergen provocation. ILIT deposits allergen in an inguinal lymph node to elicit a strong immune stimulus. This allowed us to monitor appearance of allergen specific plasmablasts 7 days after allergen injection...
2016: Clinical and Translational Allergy
Kassie A Haitz, M Shane Chapman, Gregory D Seidel
No abstract text is available yet for this article.
April 2016: Cutis; Cutaneous Medicine for the Practitioner
Michal Radomski, Herbert J Zeh, Howard D Edington, James F Pingpank, Lisa H Butterfield, Theresa L Whiteside, Eva Wieckowski, David L Bartlett, Pawel Kalinski
BACKGROUND: The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphatic injections, limiting their feasibility. Here, we report on the feasibility and safety of a new method of long-term repetitive intralymphatic (IL) infusion of immune cells, using implantable delivery ports. METHODS: Nine patients with stage IV recurrent colorectal cancer underwent complete resection and received autologous dendritic cells (DCs) loaded with killed autologous tumor cells, KLH and PADRE, for up to four monthly cycles...
2016: Journal for Immunotherapy of Cancer
Zhaowei Chu, Yanting Liu, Huan Zhang, Weihui Zeng, Songmei Geng
Melkersson-Rosenthal syndrome (MRS) is an uncommon granulomatous disease characterized by the triad of relapsing facial paralysis, orofacial swelling, and fissured tongue. Genital swelling in MRS is rarely reported. We presented the first case of complete MRS with genital swelling in a child. Biopsy examinations of both the child's lower lip and penis showed noncaseating granuloma and intralymphatic granuloma infiltration. No symptoms or signs of other systemic disease (Crohn's disease or sarcoidosis) were observed after 2 years of follow-up...
April 2016: Annals of Dermatology
Jon Konradsen, Monica Arvidsson
Allergen immunotherapy (AIT) to patients with allergy towards pollens, cats or house dust mite provides longstanding improvement of symptoms of rhinoconjunctivitis and allergic asthma and reduces the need for symptomatic medication. In addition, some studies suggest that AIT can protect from the development of asthma in children with allergic rhinitis. The clinical effects of AIT are explained by a shift from a Th2 to a Th1-mediated immune response upon allergen exposure. In Sweden the treatment is given as sublingual tablets (grass) or subcutaneous injections, and a treatment period of 3-4 years is necessary to ensure longstanding effect of the treatment...
2016: Läkartidningen
Sigridur Jonsdottir, Vilhjalmur Svansson, Sara Bjork Stefansdottir, Gertraud Schüpbach, Claudio Rhyner, Eliane Marti, Sigurbjorg Torsteinsdottir
Insect bite hypersensitivity (IBH) is an IgE-mediated dermatitis of horses caused by bites of Culicoides insects, not indigenous to Iceland. Horses born in Iceland and exported to Culicoides-rich areas are frequently affected with IBH. The aims of the study were to compare immunization with recombinant allergens using the adjuvant aluminum hydroxide (Alum) alone or combined with monophosphoryl lipid A (MPLA) for development of a preventive immunization against IBH. Twelve healthy Icelandic horses were vaccinated intralymphatically three times with 10 μg each of four recombinant Culicoides nubeculosus allergens in Alum or in Alum/MPLA...
April 2016: Veterinary Immunology and Immunopathology
S Sloot, M J Speijers, E Bastiaannet, H J Hoekstra
BACKGROUND: Intralymphatic metastases (ILM) originate from tumor cell emboli entrapped in dermal lymphatics between primary tumor and regional lymph node basin. Because of this origin, sentinel lymph node biopsy (SLNB) might increase ILM by restricting lymph flow. METHODS: Pubmed, Embase, Cochrane and Medline were searched for articles on ILM between 1980 and September 2014. ILM Incidences were calculated after wide local excision (WLE), excision with elective lymph node dissection (ELND) or therapeutic lymph node dissection (TLND), WLE with SLNB with or without completion lymph node dissection (CLND) and delayed lymph node dissection (DLND) for patients developing nodal metastasis during follow-up...
April 2016: Cancer Treatment Reviews
Lukasz Bialkowski, Alexia van Weijnen, Kevin Van der Jeught, Dries Renmans, Lidia Daszkiewicz, Carlo Heirman, Geert Stangé, Karine Breckpot, Joeri L Aerts, Kris Thielemans
The lack of appropriate mouse models is likely one of the reasons of a limited translational success rate of therapeutic vaccines against cervical cancer, as rapidly growing ectopic tumours are commonly used for preclinical studies. In this work, we demonstrate that the tumour microenvironment of TC-1 tumours differs significantly depending on the anatomical location of tumour lesions (i.e. subcutaneously, in the lungs and in the genital tract). Our data demonstrate that E7-TriMix mRNA vaccine-induced CD8(+) T lymphocytes migrate into the tumour nest and control tumour growth, although they do not express mucosa-associated markers such as CD103 or CD49a...
2016: Scientific Reports
Joaquim Marcoval, Rosa M Penín
Orofacial granulomatosis (OFG) is characterized by granulomatous inflammation in the orofacial region. Although several series have been reported, biopsy has not been performed in all cases and the histopathological features have not been extensively evaluated. Our purpose was to analyze the histopathological features of our patients with OFG. Twenty-two patients diagnosed with OFG at Bellvitge Hospital (Barcelona, Spain) from 1985 to 2010 were included in the study. All of our patients (14 men and 8 women; mean age 46...
March 2016: American Journal of Dermatopathology
Erica Russo, Alvaro Teijeira, Kari Vaahtomeri, Ann-Helen Willrodt, Joël S Bloch, Maximilian Nitschké, Laura Santambrogio, Dontscho Kerjaschki, Michael Sixt, Cornelia Halin
To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they are next passively and rapidly transported to the dLN by lymph flow. Here, we describe a role for the chemokine CCL21 in intralymphatic DC crawling. Performing time-lapse imaging in murine skin, we found that blockade of CCL21-but not the absence of lymph flow-completely abolished DC migration from capillaries toward collecting vessels and reduced the ability of intralymphatic DCs to emigrate from skin...
February 23, 2016: Cell Reports
Paola Calamaro, Lorenzo Cerroni
Intralymphatic proliferation of T-cell lymphoid blasts (IPTCLBs) is a rare, recently described entity, associated with cutaneous inflammatory conditions and characterized by intralymphatic proliferation of highly proliferating, blastoid T lymphocytes expressing CD30, thus mimicking an intravascular lymphoma. In all reported cases, the intralymphatic proliferation was associated with an underlying inflammatory condition, with no clonal T-cell receptor rearrangement, no signs of systemic or cutaneous lymphoma, and excellent prognosis...
July 2016: American Journal of Dermatopathology
Terese Hylander, Olivia Larsson, Ulla Petersson-Westin, Mia Eriksson, Susanna Kumlien Georén, Ola Winqvist, Lars-Olaf Cardell
BACKGROUND: Allergen-specific immunotherapy represents the only disease-modifying treatment for allergic diseases. We and others have previously demonstrated that intralymphatic immunotherapy (ILIT), a less time-consuming alternative to conventional subcutaneous immunotherapy (SCIT), is safe and effective. However, this has recently been disputed. The aim of this study was therefore to expand our previous trial, further assessing the safety and efficacy of ILIT. METHODS: Thirty-six patients with pollen-induced rhinoconjunctivitis were randomised to receive three intralymphatic inguinal injections of active allergen (1000 SQ-U birch- or grass-pollen) or placebo...
2016: Respiratory Research
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