Jinxuan Wang, Jianxiong Xu, Tianhu Liu, Chaoping Yu, Fengcheng Xu, Guixue Wang, Shun Li, Xiaozhen Dai
Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis. Being highly associated with the formation of atherosclerotic plaques, endocytosis is the key point in molecule and macromolecule trafficking, which plays an important role in lipid transportation. The process of endocytosis relies on the mobility and tension of the plasma membrane, which is sensitive to biomechanical forces...
2024: Frontiers in Cardiovascular Medicine