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https://www.readbyqxmd.com/read/29772049/mild-bilateral-hemorrhagic-occlusive-retinal-vasculitis-following-intracameral-vancomycin-administration-in-cataract-surgery
#1
Sruthi Arepalli, Yasha S Modi, Ryan Deasy, Sunil K Srivastava
A patient underwent cataract surgery with prophylactic intracameral vancomycin (Vancocin; Pfizer, New York City, NY) in each eye, 2 weeks apart. Four weeks after, the patient presented with a mild bilateral hemorrhagic occlusive retinal vasculitis (HORV). A systemic work-up was negative for syphilis, toxoplasmosis, Bartonella, tuberculosis, and sarcoidosis. The patient was treated with oral steroids and one intravitreal steroid injection in the left eye. Ten months after presentation, the patient's vasculitis was quiescent...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29771451/modulation-of-inflammatory-and-hormonal-parameters-in-response-to-testosterone-therapy-effects-on-the-ventral-prostate-of-adult-rats
#2
Leonardo O Mendes, Anthony C S Castilho, Cristiane F Pinho, Bianca F Gonçalvez, Eduardo M Razza, Luiz Gustavo A Chuffa, Janete A Anselmo-Franci, Wellerson R Scarano, Francisco E Martinez
Testosterone is often recommended in the treatment of several aging-related conditions. However, there are still questions about the consequences of this therapy in terms of hormonal and inflammatory parameters that are crucial for prostate homeostasis.Thus, we investigate if the testosterone therapy (TT) modulates the hormone receptors and inflammatory cytokines in the ventral prostate of adult rats. Wistar rats aging 150 days were divided into two experimental groups(n = 10/group): T: received subcutaneous injections of testosterone cypionate (5mg/kg body weight) diluted in corn oil every other day for 4 weeks; and C: received corn oil as vehicle...
May 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29770572/intralesional-steroid-injection-as-an-alternative-treatment-for-57-patients-of-vocal-fold-mucus-retention-cysts
#3
Po-Hsuan Wu, Po-Wen Cheng, Feng-Chuan Lin, Chi-Te Wang
This study intends to validate the effectiveness of vocal fold steroid injection (VFSI) for mucus retention cysts (MRCs) by comparing the treatment outcome with a control group and investigate the risk factors for recurrence. This study recruited 57 patients with vocal fold MRCs treated with in-office VFSI between January 2014 and December 2016. Another 24 patients with MRCs receiving only conservative treatment during the same study period were included as the control group. Treatment outcomes comparison of the 22 age- and sex- matched patients between the VFSI and control groups demonstrated significantly better improvements among the patients receiving VFSI in maximal phonation, perceptual voice quality, and 10-item voice handicap index...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29768371/complex-regional-pain-syndrome-type-ii-after-cervical-transforaminal-epidural-injection-a-case-report
#4
Gi-Young Park, Dong Rak Kwon, Dae Gil Kwon
RATIONALE: We report a case of a 61-year-old patient who developed complex regional pain syndrome (CRPS) type II after a cervical transforaminal epidural steroid injection (CTESI). PATIENT CONCERNS: The patient developed sudden-onset severe pain and swelling of his upper right limb after a cervical transforaminal epidural injection. DIAGNOSES: On physical examination, the patient's symptoms and signs corresponded to the Budapest criteria for CRPS...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29765299/src-kinase-dependent-rapid-non-genomic-modulation-of-hippocampal-spinogenesis-induced-by-androgen-and-estrogen
#5
Mika Soma, Jonghyuk Kim, Asami Kato, Suguru Kawato
Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by hippocampal sex steroids, including dihydrotestosterone (DHT), testosterone (T), and estradiol (E2), are essential for synaptic plasticity. Molecular mechanisms underlying the rapid non-genomic modulation through synaptic receptors of androgen (AR) and estrogen (ER) as well as its downstream kinase signaling, however, have not been well understood...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29764271/effect-of-intratympanic-steroid-injection-in-light-cupula
#6
Jin Su Park, So Yean Kim, Min-Beom Kim
OBJECTIVE: To evaluate the effects of intratympanic steroid injection (ITS) in light cupula. METHODS: A total of 47 patients showing persistent geotropic direction-changing positional nystagmus with null point (light cupula) were randomly classified into three groups: ITS (n = 15), vestibular suppressant (VS, n = 16) and canalith repositioning procedure (CRP, n = 16). Positional nystagmus and dizziness severity by dizziness handicap inventory (DHI) and visual analogue scale (VAS) were conducted before and 3 d and 1 week after first treatment to compare the effect of each treatment...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29761349/intracochlear-administration-of-steroids-with-a-catheter-during-human-cochlear-implantation-a-safety-and-feasibility-study
#7
Nils K Prenzler, Rolf Salcher, Max Timm, Lutz Gaertner, Thomas Lenarz, Athanasia Warnecke
Suppression of foreign body reaction, improvement of electrode-nerve interaction, and preservation of residual hearing are essential research topics in cochlear implantation. Intracochlear pharmaco- or cell-based therapies can open new horizons in this field. Local drug delivery strategies are desirable as higher local concentrations of agents can be realized and side effects can be minimized compared to systemic administrations. When administered locally at accessible, basal parts of the cochlea, drugs reach apical regions later and in much lower concentrations due to poor diffusion patterns in cochlear fluids...
May 14, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29759249/in-line-carbon-nanofiber-reinforced-hollow-fiber-mediated-liquid-phase-microextraction-using-a-3d-printed-extraction-platform-as-a-front-end-to-liquid-chromatography-for-automatic-sample-preparation-and-analysis-a-proof-of-concept-study
#8
Chanatda Worawit, David J Cocovi-Solberg, Pakorn Varanusupakul, Manuel Miró
A novel concept for automation of nanostructured hollow-fiber supported microextraction, combining the principles of liquid-phase microextraction (LPME) and sorbent microextraction synergically, using mesofluidic platforms is proposed herein for the first time, and demonstrated with the determination of acidic drugs (namely, ketoprofen, ibuprofen, diclofenac and naproxen) in urine as a proof-of-concept applicability. Dispersed carbon nanofibers (CNF) are immobilized in the pores of a single-stranded polypropylene hollow fiber (CNF@HF) membrane, which is thereafter accommodated in a stereolithographic 3D-printed extraction chamber without glued components for ease of assembly...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29758177/the-efficacy-of-antenatal-steroid-therapy-is-dependent-on-the-duration-of-low-concentration-fetal-exposure-evidence-from-a-sheep-model-of-pregnancy
#9
Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Timothy J Molloy, Michael Clarke, Peter J Eddershaw, Gabrielle C Musk, Augusto Schmidt, Demelza Ireland, Lucy Furfaro, Matthew S Payne, John P Newnham, Alan H Jobe
OBJECTIVE: Antenatal corticosteroids (ANS) are among the most important and widely used interventions to improve outcomes for preterm infants. ANS dosing regimens remain un-optimized and without maternal weight-adjusted dosing. We, and others, have hypothesised that once a low concentration of materno-fetal steroid exposure is achieved and maintained, the duration of the steroid exposure determines treatment efficacy. Using a sheep model of pregnancy, we tested the relationship between steroid dose, and duration of exposure, and treatment efficacy...
May 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29757716/us-assessment-of-sports-related-hip-injuries
#10
Eugen Lungu, Johan Michaud, Nathalie J Bureau
Traumatic and overuse hip injuries occur frequently in amateur and professional athletes. After clinical assessment, imaging plays an important role in diagnosis and in defining care management of these injuries. Ultrasonography (US) is being increasingly used in assessment of hip injuries because of the wide availability of US machines, the lower cost, and the unique real-time imaging capability, which allows both static and dynamic evaluation as well as guidance of point-of-care interventions such as fluid aspiration and steroid injection...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29757045/combination-therapy-for-bulky-auricular-keloids-a-clinical-experience
#11
Yanqing Yang, Changyan Jiang, Qijun Xu
Auricular keloids are common following ear piercing, infection, trauma, burns, or spontaneously, and they are highly resistant for treatment and are followed by severe cosmetic problems, especially for patients with bulky auricular keloids. The risk of recurrence and the need to return to the normal anatomy of external ear following resection is a challenge to the plastic surgeon. The authors present their experience of treating bulky auricular keloids with surgical excision, followed by immediate postoperative radiotherapy and intralesional steroid injection...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29755622/serum-triamcinolone-levels-following-cervical-interlaminar-epidural-injection
#12
Tim J Lamer, Rozalin R Dickson, Halena M Gazelka, Wayne T Nicholson, Joel M Reid, Susan M Moeschler, W Michael Hooten
Background: Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids following injection. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29755536/preclinical-study-of-ibuprofen-loaded-transnasal-mucoadhesive-microemulsion-for-neuroprotective-effect-in-mptp-mice-model
#13
Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Krutika K Sawant, Bharat Bhushan Subudhi
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation. In this work, ibuprofen loaded polycarbophil based mucoadhesive microemulsion (MMEI) was developed by using response surface methodology (RSM)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29755270/histiocytic-lesions-of-the-orbit-a-study-of-9-cases
#14
A Kaan Gündüz, Emine Temel
Purpose: To describe the clinical presentation, treatment, and outcome of patients with histiocytic lesions of the orbit. Methods: Retrospective study of 9 patients treated and followed up between October 2001 and January 2018. Results: Eight patients in our series were males and one patient was female. The mean age at presentation was 16.8 years (range, 1 to 42 years). All patients had unilateral disease. The most common presenting complaint was upper eyelid swelling in 8 of 9...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29753830/objective-technical-considerations-for-appropriate-digital-subtraction-imaging-during-cervical-transforaminal-epidural-steroid-injection
#15
Zachary L McCormick, Vinil N Shah
No abstract text is available yet for this article.
May 10, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29751191/can-epidural-contrast-dispersal-pattern-help-to-predict-the-outcome-of-transforaminal-epidural-steroid-injections-in-patients-with-lumbar-radicular-pain
#16
M D Duygu Tecer, Emre Adiguzel, Ozlem Koroglu, Arif K Tan, Mehmet A Taskaynatan
BACKGROUND: To investigate the relationship between epidurographic contrast dispersal patterns and both immediate and short term clinical effectiveness of lumbar transforaminal epidural steroid injections (TFESIs) in patients with radicular back pain. METHODS: Digital database of 64 patients who underwent single-level lumbar TFESI for unilateral lumbar radicular pain were scanned Type of contrast pattern was analyzed by 1 physiatrist and definied as follows: type I (tubular appearance); type II (nerve root visible as a filling defect); or type III (cloudlike appearance)...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29744871/the-effectiveness-of-greater-occipital-nerve-blockade-in-treating-acute-migraine-related-headaches-in-emergency-departments
#17
O Korucu, S Dagar, Ş K Çorbacioglu, E Emektar, Y Cevik
OBJECTIVE: This study aimed to evaluate the effectiveness of a greater occipital nerve (GON) blockade against a placebo and classical treatments (non-steroidal anti-inflammatory drugs + metoclopramide) among patients who were admitted to the emergency department (ED) with acute migraine headaches. METHOD: This prospective-randomized controlled study was conducted on patients with acute migraine headaches. The patients were randomly assigned to 3 treatment groups: the GON blockade group (nerve blockade with bupivacaine), the placebo group (injection of normal saline into the GON area), and the intravenous (IV) treatment group (IV dexketoprofen and metoclopramide)...
May 10, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29744227/cheilitis-glandularis-of-both-lips-successful-treatment-with-a-combination-of-an-intralesional-steroid-injection-and-tacrolimus-ointment
#18
Norberto Sugaya, Dante Migliari
Cheilitis glandularis (CG) is an inflammatory condition of unknown cause that predominantly affects the minor salivary glands of the lips. Although a diagnosis of CG is not difficult, its treatment is a challenge. This article highlights the clinical presentation of the disease together with a case of successful management of this disease using a combination of a steroid injection followed by a topical immunosuppressor.
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29742708/the-effectiveness-and-safety-of-nonsurgical-integrative-interventions-for-symptomatic-lumbar-spinal-spondylolisthesis-a-randomized-controlled-multinational-multicenter-trial-protocol
#19
Kiok Kim, Yousuk Youn, Sang Ho Lee, Jung Chul Choi, Jae Eun Jung, Jaehong Kim, Wenchun Qu, Jason Eldrige, Tae-Hun Kim
BACKGROUND: Surgery is generally accepted as the main therapeutic option for symptomatic lumbar spondylolisthesis. However, new nonsurgical therapeutic options need to be explored for this population. OBJECTIVES: The objective of this study is to assess the effectiveness and safety of a 5-week Mokhuri treatment program compared with conventional nonsurgical treatments for symptomatic lumbar spondylolisthesis. METHODS: This is a study protocol for a multinational, multicenter clinical randomized controlled trial comparing the effectiveness and safety of 5 weeks of nonsurgical integrative treatments (a Mokhuri treatment program consisting of Chuna, acupuncture, and patient education) with nonsurgical conventional treatments (drugs for pain relief, epidural steroid injections, and physical therapy)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29740507/major-risks-and-complications-of-cervical-epidural-steroid-injections-an-updated-review
#20
REVIEW
Nancy E Epstein
Background: Too many patients, with or without significant cervical disease, unnecessarily undergo cervical epidural steroid injections (CESIs). These include interlaminar (ICESI) and transforaminal ESI (TF-CESI) injections that are not Food and Drug Administration (FDA) approved, have no documented long-term efficacy, and carry severe risks and complications. Methods: Here we reviewed recent reports of morbidity and mortality attributed to the various types of CESIS...
2018: Surgical Neurology International
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