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https://www.readbyqxmd.com/read/28101815/developing-a-crowdsourcing-approach-and-tool-for-pharmacovigilance-education-material-delivery
#1
Andrew Bate, Jürgen Beckmann, Alexander Dodoo, Linda Härmark, Kenneth Hartigan-Go, Anna Hegerius, Marie Lindquist, Eugène van Puijenbroek, Marco Tuccori, Ulrich Hagemann
The number of pharmacovigilance professionals worldwide is increasing with a high staff turnover. There is a constant stream of new colleagues with an interest or need to learn about the discipline. Consequently, there is an increasing need for training in pharmacovigilance. An important step towards this has been made through developing and publishing the World Health Organization (WHO)-International Society of Pharmacovigilance (ISoP) Pharmacovigilance Curriculum. Using the Pharmacovigilance Curriculum effectively, it should be supplemented by providing comprehensive training material from various sources, and making the Pharmacovigilance Curriculum attractive and a high-utility product...
January 18, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28070474/recent-trends-in-the-prevalence-of-low-dose-aspirin-use-for-primary-and-secondary-prevention-of-cardiovascular-disease-in-the-united-states-2012-2015
#2
Mark Stuntz, Brent Bernstein
Aspirin therapy has been shown to be an effective prevention measure to reduce the risk of new or recurring cardiovascular events. The aim of this study was to provide an epidemiological analysis of low-dose aspirin use for primary and secondary CVD prevention from 2012 to 2015. Estimates of self-reported low-dose aspirin use for primary and secondary CVD prevention were obtained from the National Health Interview Survey for the years 2012-2015. Temporal changes in the prevalence of aspirin use for primary and secondary CVD prevention were assessed using logistic regression...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28068954/cognitively-and-physically-demanding-exergaming-to-improve-executive-functions-of-children-with-attention-deficit-hyperactivity-disorder-a-randomised-clinical-trial
#3
Valentin Benzing, Mirko Schmidt
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders observed in childhood and adolescence. Its key symptoms - reduced attention, poor control of impulses as well as increased motor activity - are associated with decreased executive functions performance, finally affecting academic achievement. Although drug treatments usually show some effect, alternative treatments are continually being sought, due to lack of commitment and possible side effects...
January 10, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28035775/reducing-liberal-red-blood-cell-transfusions-at-an-academic-medical-center
#4
Harry S Saag, Claudette M Lajam, Simon Jones, Nikita Lakomkin, Joseph A Bosco, Rebecca Wallack, Spiros G Frangos, Prashant Sinha, Nicole Adler, Patti Ursomanno, Leora I Horwitz, Frank M Volpicelli
BACKGROUND: Educational and computerized interventions have been shown to reduce red blood cell (RBC) transfusion rates, yet controversy remains surrounding the optimal strategy needed to achieve sustained reductions in liberal transfusions. STUDY DESIGN AND METHODS: The purpose of this study was to assess the impact of clinician decision support (CDS) along with targeted education on liberal RBC utilization to four high-utilizing service lines compared with no education to control service lines across an academic medical center...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/27995539/use-of-electronic-resources-for-psychiatry-clerkship-learning-a-medical-student-survey
#5
Caitlin E Snow, John Torous, Janna S Gordon-Elliott, Julie B Penzner, Fermonta Meyer, Robert Boland
OBJECTIVE: The primary aim of this study is to examine medical students' use patterns, preferences, and perceptions of electronic educational resources available for psychiatry clerkship learning. METHODS: Eligible participants included medical students who had completed the psychiatry clerkship during a 24-month period. An internet-based questionnaire was used to collect information regarding the outcomes described above. RESULTS: A total of 68 medical students responded to the survey...
December 19, 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/27939174/challenges-in-the-development-of-an-m4-pam-in-vivo-tool-compound-the-discovery-of-vu0467154-and-unexpected-dmpk-profiles-of-close-analogs
#6
Michael R Wood, Meredith J Noetzel, Michael S Poslusney, Bruce J Melancon, James C Tarr, Atin Lamsal, Sichen Chang, Vincent B Luscombe, Rebecca L Weiner, Hyekyung P Cho, Michael Bubser, Carrie K Jones, Colleen M Niswender, Michael W Wood, Darren W Engers, Nicholas J Brandon, Mark E Duggan, P Jeffrey Conn, Thomas M Bridges, Craig W Lindsley
This letter describes the chemical optimization of a novel series of M4 positive allosteric modulators (PAMs) based on a 5-amino-thieno[2,3-c]pyridazine core, developed via iterative parallel synthesis, and culminating in the highly utilized rodent in vivo tool compound, VU0467154 (5). This is the first report of the optimization campaign (SAR and DMPK profiling) that led to the discovery of VU0467154, and details all of the challenges faced in allosteric modulator programs (steep SAR, species differences in PAM pharmacology and subtle structural changes affecting CNS penetration)...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27913830/genome-scale-modeling-of-thermophilic-microorganisms
#7
Sanjeev Dahal, Suresh Poudel, R Adam Thompson
Thermophilic microorganisms are of increasing interest for many industries as their enzymes and metabolisms are highly efficient at elevated temperatures. However, their metabolic processes are often largely different from their mesophilic counterparts. These differences can lead to metabolic engineering strategies that are doomed to fail. Genome-scale metabolic modeling is an effective and highly utilized way to investigate cellular phenotypes and to test metabolic engineering strategies. In this review we chronicle a number of thermophilic organisms that have recently been studied with genome-scale models...
December 3, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27890750/the-use-of-social-media-communications-in-brain-aneurysms-and-subarachnoid-hemorrhage-a-mixed-method-analysis
#8
Naif M Alotaibi, Nardin Samuel, Justin Wang, Christopher S Ahuja, Daipayan Guha, George M Ibrahim, Tom A Schweizer, Gustavo Saposnik, R Loch Macdonald
BACKGROUND: The diagnosis of a ruptured or unruptured brain aneurysm has a significant impact on patients' quality of life and their psychosocial wellbeing. As a result, patients and caregivers may resort to social media platforms for support and education. The aim of this report is to evaluate the current use of social media and the online communications regarding brain aneurysms. METHODS: Three social media platforms (Facebook, Twitter and YouTube) were assessed for public content pertaining to brain aneurysms in March 2016...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27825700/boronate-affinity-based-surface-molecularly-imprinted-polymers-using-glucose-as-fragment-template-for-excellent-recognition-of-glucosides
#9
Mijun Peng, Haiyan Xiang, Xin Hu, Shuyun Shi, Xiaoqing Chen
Rapid and efficient extraction of bioactive glycosides from complex natural origins poses a difficult challenge, and then is often inherent bottleneck for their highly utilization. Herein, we propose a strategy to fabricate boronate affinity based surface molecularly imprinted polymers (MIPs) for excellent recognition of glucosides. d-glucose was used as fragment template. Boronic acid, dynamic covalent binding with d-glucose under different pH conditions, was selected as functional monomer to improve specificity...
October 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27824190/biomass-lysine-derived-nitrogen-doped-carbon-hollow-cubes-via-a-nacl-crystal-template-an-efficient-bifunctional-electrocatalyst-for-oxygen-reduction-and-evolution-reactions
#10
Xiangjun Zheng, Xuecheng Cao, Xiaowei Li, Jinghua Tian, Chao Jin, Ruizhi Yang
Nitrogen-doped carbon hollow cubes (NCHCs) are fabricated from biomass l-lysine monohydrochloride via a facile and low-cost NaCl template process, showing efficient bifunctional electrocatalytic activities towards the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The resultant lysine-derived carbon hollow cubes with hierarchical pores on the wall are conducive to mass transport and high utilization of nitrogen dopant-induced active sites during the electrocatalytic process. When used as electrocatalysts for the ORR, an onset potential of 0...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/27800600/cholestyramine-as-a-promising-strong-anion-exchange-resin-for-direct-capture-of-genetic-biomarkers-from-raw-pancreatic-fluids
#11
Andrew J Hilmer, R Brooke Jeffrey, Walter G Park, Chaitan Khosla
The ability to capture cell-free DNA from the gastrointestinal tract, in a minimally invasive manner, could enhance our ability to diagnose gastrointestinal disease, or gain a better understanding of the spatial mapping of the intestinal microbiota. We therefore sought to identify a class of capture agents that could directly and efficiently sequester genetic material from intestinal fluids. As a particular case study, we examined the ability to capture DNA from pancreatic secretions, for potential application in enabling the sequestration of early, genetic biomarkers of pancreatic disease...
November 1, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27774384/janus-separator-of-polypropylene-supported-cellular-graphene-framework-for-sulfur-cathodes-with-high-utilization-in-lithium-sulfur-batteries
#12
Hong-Jie Peng, Dai-Wei Wang, Jia-Qi Huang, Xin-Bing Cheng, Zhe Yuan, Fei Wei, Qiang Zhang
Owing to the conversion chemistry of the sulfur cathode, the lithium-sulfur (Li-S) batteries exhibit high theoretical energy density. However, the intrinsic mobile redox centers during the sulfur/Li2S-to-lithium polysulfides solid-to-liquid phase transition induce low sulfur utilization and poor cycling life. Herein, the Janus separator of mesoporous cellular graphene framework (CGF)/polypropylene membrane to promote the utilization of sulfur cathode is introduced. The porous polypropylene membrane serves as an insulating substrate in contact with lithium anode while CGFs that possess high electrical conductivity of 100 S cm(-1), a large mesopore volume of 3...
January 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27758090/the-rise-and-future-of-glyphosate-and-glyphosate-resistant-crops
#13
Jerry M Green
Glyphosate and glyphosate-resistant crops had a revolutionary impact on weed management practices, but the epidemic of glyphosate-resistant (GR) weeds is rapidly decreasing the value of these technologies. In areas that fully adopted glyphosate and GR crops, GR weeds evolved and glyphosate and glyphosate traits now must be combined with other technologies. The chemical company solution is to combine glyphosate with other chemicals, and the seed company solution is to combine glyphosate resistance with other traits...
October 18, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27735930/prenatal-visit-utilization-and-outcomes-in-pregnant-women-with-type-ii-and-gestational-diabetes
#14
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27733138/a-qualitative-study-on-factors-that-influence-women-s-choice-of-delivery-in-health-facilities-in-addis-ababa-ethiopia
#15
Tigest Shifraw, Yemane Berhane, Hanna Gulema, Tamil Kendall, Anne Austin
BACKGROUND: Facility based delivery for mothers is one of the proven interventions to reduce maternal and neonatal morbidity and mortality. This study identified women's reasons for seeking to give birth in a health facility and captured their perceptions of the quality of care they received during their most recent birth, in a population with high utilization of facility based deliveries. METHODS: This qualitative study was conducted in eight health centers in Addis Ababa...
October 12, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27723317/selenocysteine-as-a-latent-bioorthogonal-electrophilic-probe-for-deubiquitylating-enzymes
#16
Samuel D Whedon, Nagula Markandeya, Ambar S J B Rana, Caroline E Weller, Nicholas A Senger, Frantisek Turecek, Eric R Strieter, Champak Chatterjee
Deubiquitylating enzymes (DUBs) remove ubiquitin (Ub) from various cellular proteins and render eukaryotic ubiquitylation a dynamic process. The misregulation of protein ubiquitylation is associated with many human diseases, and there is an urgent need to identify specific DUBs associated with therapeutically relevant targets of Ub. We report the development of two facile selenocysteine-based strategies to generate the DUB probe dehydroalanine (Dha). Optimized oxidative or alkylative elimination of Se yielded Dha at the C-terminus of Ub...
October 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27720381/borrelia-burgdorferi-dna-absent-multiple-rickettsia-spp-dna-present-in-ticks-collected-from-a-teaching-forest-in-north-central-florida
#17
Katherine Sayler, Jessica Rowland, Carisa Boyce, Emma Weeks
Tick-borne diseases are an emerging public health threat in the United States. In Florida, there has been public attention directed towards the possibility of locally acquired Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, in association with the lone star tick. The aim of this study was to determine the prevalence of ticks and the pathogens they carry and potentially transmit, such as B. burgdorferi, in a highly utilized teaching and research forest in North Central Florida. Ticks were collected by dragging and flagging methods over a four month period in early 2014, identified, and tested by PCR for multiple pathogens including Anaplasma, Borrelia, Rickettsia, and Ehrlichia species...
January 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27712896/choroid-detachment-a-rare-cause-of-vision-loss-diagnosed-by-point-of-care-ultrasound
#18
Brian Jarrett, Michael Secko
BACKGROUND: Choroid detachment is a rare disease process that has a multitude of etiologies; usually related to recent ophthalmological surgery, eye trauma, corneal ulcers, or intraocular pressure-lowering agents. Point-of-care ocular ultrasound has high utility and accuracy in diagnosing pathology of the eye. CASE REPORT: We present a case of a patient who presented with vision loss caused by a choroid detachment diagnosed on point-of-care ultrasound because fundoscopic examination was limited due to cataracts...
October 3, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27700621/use-of-visual-range-measurements-to-predict-fine-particulate-matter-exposures-in-southwest-asia-and-afghanistan
#19
Shahir Masri, Eric Garshick, Jaime Hart, Walid Bouhamra, Petros Koutrakis
: Military personnel deployed to Southwest Asia and Afghanistan were exposed to high levels of ambient particulate matter (PM). However, quantitative ambient exposure data for conducting health studies are limited due to a lack of PM monitoring stations. Since visual range (VR) is proportional to particle light extinction, VR can serve as a surrogate for PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 µm) concentrations. We used data on VR, relative humidity (RH), and PM2...
2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/27677560/comparison-of-emergency-department-wait-times-in-adults-with-sickle-cell-disease-versus-other-painful-etiologies
#20
Dianne Pulte, Paris B Lovett, David Axelrod, Albert Crawford, John McAna, Rhea Powell
Sickle cell disease is characterized by intermittent painful crises often requiring treatment in the emergency department (ED). Past examinations of time-to-provider (TTP) in the ED for patients with sickle cell disease demonstrated that these patients may have longer TTP than other patients. Here, we examine TTP for patients presenting for emergency care at a single institution, comparing patients with sickle cell disease to both the general population and to those with other painful conditions, with examination of both institutional and patient factors that might affect wait times...
September 2016: Hemoglobin
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