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https://www.readbyqxmd.com/read/28098949/identification-of-cellular-targets-involved-in-cardiac-failure-caused-by-pki-in-oncology-an-approach-combining-pharmacovigilance-and-pharmacodynamics
#1
E Patras de Campaigno, E Bondon-Guitton, G Laurent, F Montastruc, J L Montastruc, M Lapeyre-Mestre, F Despas
AIMS: To evaluate the risk of cardiac failure (CF) of 15 anticancer protein kinase inhibitors (PKIs) through a case/non-case analysis and to identify which PK(s) and pathways are involved in PKI-induced CF. METHODS: To evaluate the risk of CF, adjusted reporting odds ratios (aRORs) were calculated for the 15 anticancer PKIs in the WHO safety report database (VigiBase®). We realised a literature review to identify 21 PK possibly involved in CF caused by PKIs. Pearson's correlation coefficients (r) between aROR and affinity data of the 15 PKIs for the 21 PKs were calculated to identify the cellular target most likely involved in PKI-induced CF...
January 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28098842/modulation-index-adjustment-for-recovery-of-pure-wavelength-modulation-spectroscopy-second-harmonic-signal-waveforms
#2
Wei Wei, Jun Chang, Qiang Wang, Zengguang Qin
A new technique of modulation index adjustment for pure wavelength modulation spectroscopy second harmonic signal waveforms recovery is presented. As the modulation index is a key parameter in determining the exact form of the signals generated by the technique of wavelength modulation spectroscopy, the method of modulation index adjustment is applied to recover the second harmonic signal with wavelength modulation spectroscopy. By comparing the measured profile with the theoretical profile by calculation, the relationship between the modulation index and average quantities of the scanning wavelength can be obtained...
January 15, 2017: Sensors
https://www.readbyqxmd.com/read/28098833/role-of-electron-driven-proton-transfer-processes-in-the-ultrafast-deactivation-of-photoexcited-anionic-8-oxoguanine-adenine-and-8-oxoguanine-cytosine-base-pairs
#3
Xiuxiu Wu, Tolga N V Karsili, Wolfgang Domcke
It has been reported that 8-oxo-7,8-dihydro-guanosine (8-oxo-G), which is the main product of oxidative damage of DNA, can repair cyclobutane pyrimidine dimer (CPD) lesions when incorporated into DNA or RNA strands in proximity to such lesions. It has therefore been suggested that the 8-oxo-G nucleoside may have been a primordial precursor of present-day flavins in DNA or RNA repair. Because the electron transfer leading to the splitting of a thymine-thymine pair in a CPD lesion occurs in the photoexcited state, a reasonably long excited-state lifetime of 8-oxo-G is required...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098829/rapid-transfer-alignment-of-mems-sins-based-on-adaptive-incremental-kalman-filter
#4
Hairong Chu, Tingting Sun, Baiqiang Zhang, Hongwei Zhang, Yang Chen
In airborne MEMS SINS transfer alignment, the error of MEMS IMU is highly environment-dependent and the parameters of the system model are also uncertain, which may lead to large error and bad convergence of the Kalman filter. In order to solve this problem, an improved adaptive incremental Kalman filter (AIKF) algorithm is proposed. First, the model of SINS transfer alignment is defined based on the "Velocity and Attitude" matching method. Then the detailed algorithm progress of AIKF and its recurrence formulas are presented...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28098807/throughput-measurement-of-a-dual-band-mimo-rectangular-dielectric-resonator-antenna-for-lte-applications
#5
Jamal Nasir, Mohd Haizal Jamaluddin, Aftab Ahmad Khan, Muhammad Ramlee Kamarudin, Bruce Leow Chee Yen, Owais Owais
An L-shaped dual-band multiple-input multiple-output (MIMO) rectangular dielectric resonator antenna (RDRA) for long term evolution (LTE) applications is proposed. The presented antenna can transmit and receive information independently using fundamental TE111 and higher order TE121 modes of the DRA. TE111 degenerate mode covers LTE band 2 (1.85-1.99 GHz), 3 (1.71-1.88 GHz), and 9 (1.7499-1.7849 GHz) at fr = 1.8 GHz whereas TE121 covers LTE band 7 (2.5-2.69 GHz) at fr = 2.6 GHz, respectively. An efficient design method has been used to reduce mutual coupling between ports by changing the effective permittivity values of DRA by introducing a cylindrical air-gap at an optimal position in the dielectric resonator...
January 13, 2017: Sensors
https://www.readbyqxmd.com/read/28098790/synthesis-structure-and-antimicrobial-properties-of-novel-benzalkonium-chloride-analogues-with-pyridine-rings
#6
Bogumił Brycki, Izabela Małecka, Anna Koziróg, Anna Otlewska
Quaternary ammonium compounds (QACs) are a group of compounds of great economic significance. They are widely used as emulsifiers, detergents, solubilizers and corrosion inhibitors in household and industrial products. Due to their excellent antimicrobial activity QACs have also gained a special meaning as antimicrobials in hospitals, agriculture and the food industry. The main representatives of the microbiocidal QACs are the benzalkonium chlorides (BACs), which exhibit biocidal activity against most bacteria, fungi, algae and some viruses...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098780/adding-salt-to-meals-as-a-risk-factor-of-type-2-diabetes-mellitus-a-case-control-study
#7
Lina Radzeviciene, Rytas Ostrauskas
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is thought to arise from the complex interplay between genetic and environmental factors. It is important to identify modifiable risk factors that may help to reduce the risk of diabetes. Data on salt intake and the risk of type 2 diabetes are limited. The aim of this study was to assess the relationship between adding salt to prepared meals and the risk of type 2 diabetes. METHODS: In a case-control study, we included 234 cases, all of whom were patients aged 35-86 years with a newly confirmed diagnosis of T2DM, and 468 controls that were free of the disease...
January 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28098767/cheese-consumption-and-risk-of-all-cause-mortality-a-meta-analysis-of-prospective-studies
#8
Xing Tong, Guo-Chong Chen, Zheng Zhang, Yu-Lu Wei, Jia-Ying Xu, Li-Qiang Qin
The association between cheese consumption and risk for major health endpoints has been investigated in many epidemiologic studies, but findings are inconsistent. As all-cause mortality can be viewed as the final net health effect of dietary intakes, we conducted a meta-analysis to examine the long-term association of cheese consumption with all-cause mortality. Relevant studies were identified by a search of the PubMed database through May 2016. Reference lists from retrieved articles were also reviewed. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using a random-effects model...
January 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28098765/validation-of-an-online-food-frequency-questionnaire-against-doubly-labelled-water-and-24-h-dietary-recalls-in-pre-school-children
#9
Christine Delisle Nyström, Hanna Henriksson, Christina Alexandrou, Anna Bergström, Stephanie Bonn, Katarina Bälter, Marie Löf
The development of easy-to-use and accurate methods to assess the intake of energy, foods and nutrients in pre-school children is needed. KidMeal-Q is an online food frequency questionnaire developed for the LifeGene prospective cohort study in Sweden. The aims of this study were to compare: (i) energy intake (EI) obtained using KidMeal-Q to total energy expenditure (TEE) measured via doubly labelled water and (ii) the intake of certain foods measured using KidMeal-Q to intakes acquired by means of 24 h dietary recalls in 38 children aged 5...
January 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28098763/new-abietane-and-kaurane-type-diterpenoids-from-the-stems-of-tripterygium-regelii
#10
Dongsheng Fan, Shuangyan Zhou, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Ming-Rong Yang, Zhi-Hong Jiang, Li-Ping Bai
Eleven new abietane type (1‒11), and one new kaurane (12), diterpenes, together with eleven known compounds (13-23), were isolated and identified from the stems of Tripterygium regelii, which has been used as a traditional folk Chinese medicine for the treatment of rheumatoid arthritis in China. The structures of new compounds were characterized by means of the interpretation of high-resolution electrospray ionization mass spectrometry (HRESIMS), extensive nuclear magnetic resonance (NMR) spectroscopic data and comparisons of their experimental CD spectra with calculated electronic circular dichroism (ECD) spectra...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098742/does-transection-of-the-c2-nerve-roots-during-c1-lateral-mass-screw-placement-for-atlantoaxial-fixation-result-in-a-superior-outcome-a-systematic-review-of-the-literature-and-meta-analysis
#11
Jetan H Badhiwala, Farshad Nassiri, Christopher D Witiw, Alireza Mansouri, Saleh A Almenawer, Michael G Fehlings
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To evaluate the clinical and functional outcomes of transection of the C2 roots during C1 lateral mass screw placement for atlantoaxial fixation. SUMMARY OF BACKGROUND DATA: Transection of the C2 nerve roots has been recommended during atlantoaxial fixation to facilitate C1 lateral mass screw placement and possibly reduce post-operative occipital neuralgia, although this practice remains controversial...
January 16, 2017: Spine
https://www.readbyqxmd.com/read/28098726/assessment-of-retinal-blood-flow-in-diabetic-retinopathy-using-doppler-fourier-domain-optical-coherence-tomography
#12
Sowmya Srinivas, Ou Tan, Muneeswar G Nittala, Jennifer L Wu, Amani A Fazwi, David Huang, SriniVas R Sadda
PURPOSE: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). METHODS: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098711/primary-septal-cartilage-graft-for-the-unilateral-cleft-rhinoplasty
#13
Ting-Chen Lu, Chuan-Fong Yao, Susie Lin, Chun-Shin Chang, Philip Kuo-Ting Chen
PROPOSE: Since 2006, we have explored the option of using septal cartilage as an alar rim graft on the cleft side during primary rhinoplasty to improve nasal symmetry. The aim of this study was to compare the nasal shape with or without rim graft. METHODS: A total of 98 patients with unilateral complete cleft lip and palate were included; 39 patients had septal cartilage as the rim graft, 59 patients did not. Measurements of the nostril height, nostril width, 1/4 medial part of nostril height, nostril area, nasal dome height and nostril axis were made on the cleft and non-cleft side...
January 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28098666/estimated-internal-and-external-radiation-exposure-of-caregivers-of-patients-with-pediatric-neuroblastoma-undergoing-131i-metaiodobenzylguanidine-therapy-a-prospective-pilot-study
#14
Sangwon Han, Seon Hee Yoo, Kyung-Nam Koh, Jong Jin Lee
PURPOSE: Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. MATERIALS AND METHODS: Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission...
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28098624/long-term-survival-in-adults-treated-with-extracorporeal-membrane-oxygenation-for-respiratory-failure-and-sepsis
#15
Viktor von Bahr, Jan Hultman, Staffan Eksborg, Björn Frenckner, Håkan Kalzén
OBJECTIVE: The use of extracorporeal membrane oxygenation in adults with respiratory failure and sepsis is steadily increasing, but the knowledge on long-term survival in this group is scarce. The aim of the present study was to investigate the 5-year survival rates and causes of late death in this group of patients. DESIGN: Single-center retrospective cohort study. SETTING: Karolinska University Hospital, Stockholm, Sweden. PATIENTS: Adult patients treated with extracorporeal membrane oxygenation for respiratory failure and sepsis between the service being established for adults in 1995 and December 2013...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28098584/interrater-agreement-of-manual-palpation-for-identification-of-myofascial-trigger-points-a-systematic-review-and-meta-analysis
#16
Alasdair T L Rathbone, Liza Grosman-Rimon, Dinesh A Kumbhare
OBJECTIVE: To achieve a statistical estimate of the agreement of manual palpation for identification of myofascial trigger points (MTrPs) and secondarily to investigate potential factors impacting the agreement of this technique. METHODS: We searched MEDLINE(R) and Embase for studies examining the reproducibility of manual palpation for the identification of MTrPs from the year 2007 to present. In addition, we utilized studies identified by 2 comprehensive systematic reviews that covered the period before 2007...
January 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28098578/helicobacter-pylori-and-risk-of-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#17
Karn Wijarnpreecha, Charat Thongprayoon, Panadeekarn Panjawatanan, Wuttiporn Manatsathit, Veeravich Jaruvongvanich, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Patients with H. pylori infection may be at an increased risk of nonalcoholic fatty liver disease (NAFLD) because of chronic inflammation and insulin resistance. Several epidemiologic studies attempting to determine this risk have yielded inconsistent results. This meta-analysis was conducted with the aims to summarize all available evidence and estimate the risk of NAFLD in patients with H...
January 17, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28098571/operating-room-anesthesia-subspecialization-is-not-associated-with-significantly-greater-quality-of-supervision-of-anesthesia-residents-and-nurse-anesthetists
#18
Franklin Dexter, Johannes Ledolter, Richard H Epstein, Bradley J Hindman
BACKGROUND: Supervision of anesthesia residents and nurse anesthetists is a major responsibility of faculty anesthesiologists. The quality of their supervision can be assessed quantitatively by the anesthesia residents and nurse anesthetists. Supervision scores are an independent measure of the contribution of the anesthesiologist to patient care. We evaluated the association between quality of supervision and level of specialization of anesthesiologists. METHODS: We used two 6-month periods, one with no feedback to anesthesiologists of the residents' and nurse anesthetists' evaluations, and the other with feedback...
November 2, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28098464/clustering-of-uracil-molecules-on-ice-nanoparticles
#19
Andriy Pysanenko, Jaroslav Kocisek, Dana Nachtigallova, Viktoriya Poterya, Michal Farnik
We generate a molecular beam of ice nanoparticles (H2O)N, N ∼130 - 220, which pick up several individual gas phase uracil (U) or 5-bromouracil (BrU) molecules. The mass spectra of the doped nanoparticles prove that the uracil and bromouracil molecules coagulate to clusters on the ice nanoparticles. Calculations of U and BrU monomers and dimers on the ice nanoparticles provide theoretical support for the cluster formation. The (U)nH(+) and (BrU)nH(+) intensity dependencies on m extracted from the mass spectra suggest a smaller tendency of BrU to coagulate compared to U, which is substantiated by a lower mobility of bromouracil on the ice surface...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28098463/absolute-configuration-of-native-oligomeric-proanthocyanidins-with-dentin-biomodification-potency
#20
Joo-Won Nam, Rasika S Phansalkar, David C Lankin, James B McAlpine, Ariene A Leme-Kraus, Cristina M P Vidal, Li-She Gan, Ana Bedran-Russo, Shao-Nong Chen, Guido F Pauli
The structurally complex oligomeric proanthocyanidins (OPACs) are promising biomimetic agents, capable of strengthening the macromolecular backbone of teeth via intermolecular and intermicrofibrillar cross-linking. This study establishes analytical methods capable of determining the absolute configuration of the catechin-type monomeric units of underivatized OPACs. This preserves the capacity of their biological evaluation, aimed at understanding the inevitably stereospecific interactions between the OPACs and dentin collagen...
January 18, 2017: Journal of Organic Chemistry
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