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https://www.readbyqxmd.com/read/29776411/a-study-of-the-factors-associated-with-cervical-spinal-disc-degeneration-with-a-focus-on-bone-metabolism-and-amino-acids-in-the-japanese-population-a-cross-sectional-study
#1
Kanichiro Wada, Toshihiro Tanaka, Gentaro Kumagai, Hitoshi Kudo, Toru Asari, Daisuke Chiba, Seiya Ota, Keita Kamei, On Takeda, Shigeyuki Nakaji, Yasuyuki Ishibashi
BACKGROUND: The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. METHODS: Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29773874/mutations-in-six-nephrosis-genes-delineate-a-pathogenic-pathway-amenable-to-treatment
#2
Shazia Ashraf, Hiroki Kudo, Jia Rao, Atsuo Kikuchi, Eugen Widmeier, Jennifer A Lawson, Weizhen Tan, Tobias Hermle, Jillian K Warejko, Shirlee Shril, Merlin Airik, Tilman Jobst-Schwan, Svjetlana Lovric, Daniela A Braun, Heon Yung Gee, David Schapiro, Amar J Majmundar, Carolin E Sadowski, Werner L Pabst, Ankana Daga, Amelie T van der Ven, Johanna M Schmidt, Boon Chuan Low, Anjali Bansal Gupta, Brajendra K Tripathi, Jenny Wong, Kirk Campbell, Kay Metcalfe, Denny Schanze, Tetsuya Niihori, Hiroshi Kaito, Kandai Nozu, Hiroyasu Tsukaguchi, Ryojiro Tanaka, Kiyoshi Hamahira, Yasuko Kobayashi, Takumi Takizawa, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Naonori Kumagai, Kazumoto Iijima, Henry Fehrenbach, Jameela A Kari, Sherif El Desoky, Sawsan Jalalah, Radovan Bogdanovic, Nataša Stajić, Hildegard Zappel, Assel Rakhmetova, Sharon-Rose Wassmer, Therese Jungraithmayr, Juergen Strehlau, Aravind Selvin Kumar, Arvind Bagga, Neveen A Soliman, Shrikant M Mane, Lewis Kaufman, Douglas R Lowy, Mohamad A Jairajpuri, Richard P Lifton, York Pei, Martin Zenker, Shigeo Kure, Friedhelm Hildebrandt
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20, ITSN1, ITSN2) as causing NS in 17 families with partially treatment-sensitive NS (pTSNS). These proteins interact and we delineate their roles in Rho-like small GTPase (RLSG) activity, and demonstrate deficiency for mutants of pTSNS patients. We find that CDK20 regulates DLC1. Knockdown of MAGI2, DLC1, or CDK20 in cultured podocytes reduces migration rate...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29772101/computer-aided-diagnosis-of-prostate-cancer-on-magnetic-resonance-imaging-using-a-convolutional-neural-network-algorithm
#3
Junichiro Ishioka, Yoh Matsuoka, Sho Uehara, Yosuke Yasuda, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Kazutaka Saito, Kazunori Kihara, Noboru Numao, Tomo Kimura, Kosei Kudo, Itsuo Kumazawa, Yasuhisa Fujii
OBJECTIVES: To develop a computer-aided diagnosis (CAD) algorithm with a deep learning architecture for detecting prostate cancer on magnetic resonance imaging (MRI) to promote global standardization and diminish variation in the interpretation of prostate MRI. PATIENTS AND METHODS: We retrospectively reviewed data from 335 patients with a prostate specific antigen level of less than 20 ng/ml who underwent MRI and extended systematic prostate biopsy with or without MRI-targeted biopsy...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29766749/enhanced-sternal-healing-via-platelet-rich-plasma-and-biodegradable-gelatin-hydrogel
#4
Masafumi Shibata, Gen Takagi, Mitsuhiro Kudo, Jiro Kurita, Yoko Kawamoto, Yasuo Miyagi, Mikimoto Kanazashi, Takashi Sakatani, Zenya Naito, Yasuhiko Tabata, Masaaki Miyamoto, Takashi Nitta
Platelet-rich plasma (PRP) contains numerous growth factors and promotes bone fracture healing. The aim of this study was to evaluate the effectiveness of the controlled release of PRP from biodegradable gelatin hydrogel for promoting healing in a rabbit ischemic sternal model. PRP was prepared from the whole blood of a Japanese white rabbit. Sixteen rabbits were randomized into four groups (each n = 4) and all underwent median sternotomy and bilateral internal thoracic artery removal. Before the sternum was closed, the following solutions were applied between the sternum incisions in three of the groups: 30 mg of gelatin hydrogel incorporating 300 μL of phosphate-buffered saline, 300 μL of a solution form of PRP, or 30 mg of gelatin hydrogel incorporating 300 μL of PRP (PRP+Gel)...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29766378/2-methacryloyloxyethyl-phosphorylcholine-mpc-polymer-suppresses-an-increase-of-oral-bacteria-a-single-blind-crossover-clinical-trial
#5
Natsumi Fujiwara, Hiromichi Yumoto, Koji Miyamoto, Katsuhiko Hirota, Hiromi Nakae, Saya Tanaka, Keiji Murakami, Yasusei Kudo, Kazumi Ozaki, Yoichiro Miyake
OBJECTIVES: The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. The aim of this study is to clarify whether MPC-polymer can suppress the bacterial adherence in oral cavity by a crossover design. We also investigated the number of Fusobacterium nucleatum, which is the key bacterium forming dental plaque, in clinical samples. MATERIALS AND METHODS: This study was a randomized, placebo-controlled, single-blind, crossover study, with two treatment periods separated by a 2-week washout period...
May 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29758011/invasion-related-factors-as-potential-diagnostic-and-therapeutic-targets-in-oral-squamous-cell-carcinoma-a-review
#6
REVIEW
Samadarani B S M Siriwardena, Takaaki Tsunematsu, Guangying Qi, Naozumi Ishimaru, Yasusei Kudo
It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)-the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29756017/endocytoscopic-findings-of-colorectal-neuroendocrine-tumors-with-video
#7
Kenichi Takeda, Shin-Ei Kudo, Masashi Misawa, Yuichi Mori, Miki Yamano, Haruhiro Inoue
Background and study aims  Gastrointestinal neuroendocrine tumors (NET) are generally submucosal in location. Because these tumors are covered with normal mucosa, biopsy is necessary to confirm histological diagnosis before treatment. We explored the diagnostic capabilities of the endocytoscope, which can perform ultra-high magnification in vivo, for staining and diagnosing submucosal tumors in situ.
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29755848/ct-dose-modulation-using-automatic-exposure-control-in-whole-body-pet-ct-effects-of-scout-imaging-direction-and-arm-positioning
#8
Yusuke Inoue, Kazunori Nagahara, Hiroko Kudo, Hiroyasu Itoh
Automatic exposure control (AEC) modulates tube current and consequently X-ray exposure in CT. We investigated the behavior of AEC systems in whole-body PET/CT. CT images of a whole-body phantom were acquired using AEC on two scanners from different manufactures. The effects of scout imaging direction and arm positioning on dose modulation were evaluated. Image noise was assessed in the chest and upper abdomen. On one scanner, AEC using two scout images in the posteroanterior (PA) and lateral (Lat) directions provided relatively constant image noise along the z-axis with the arms at the sides...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29753741/long-term-hindlimb-unloading-causes-a-preferential-reduction-of-medullary-thymic-epithelial-cells-expressing-autoimmune-regulator-aire
#9
Kenta Horie, Takashi Kudo, Riko Yoshinaga, Nobuko Akiyama, Hiroki Sasanuma, Tetsuya J Kobayashi, Miki Shimbo, Hyojung Jeon, Takahisa Miyao, Maki Miyauchi, Masaki Shirakawa, Dai Shiba, Nobuaki Yoshida, Masafumi Muratani, Satoru Takahashi, Taishin Akiyama
Hindlimb unloading (HU) of rodents has been used as a ground-based model of spaceflight. In this study, we investigated the detailed impact of 14-day HU on the murine thymus. Thymic mass and cell number were significantly reduced after 14 days of hindlimb unloading, which was accompanied by an increment of plasma corticosterone. Although corticosterone reportedly causes selective apoptosis of CD4+ CD8+ thymocytes (CD4+ CD8+ DPs) in mice treated with short-term HU, the reduction of thymocyte cellularity after the 14-day HU was not selective for CD4+ CD8+ DPs...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29753740/2-deoxy-d-glucose-increases-gfat1-phosphorylation-resulting-in-endoplasmic-reticulum-related-apoptosis-via-disruption-of-protein-n-glycosylation-in-pancreatic-cancer-cells
#10
Kousuke Ishino, Mitsuhiro Kudo, Wei-Xia Peng, Shoko Kure, Kiyoko Kawahara, Kiyoshi Teduka, Yoko Kawamoto, Taeko Kitamura, Takenori Fujii, Tetsushi Yamamoto, Ryuichi Wada, Zenya Naito
The glycolytic inhibitor 2-deoxy-d-glucose (2DG) causes energy starvation, affecting cell viability in a wide range of cancer cell lines. To determine the action of 2DG in pancreatic cancer, we performed proteomic analysis of pancreatic cancer cell line after 2DG treatment. Eighty proteins showed differential expression and among these, proteins involved in phosphohexose metabolism were upregulated. Up-regulation of glutamine: fructose 6-phosphate aminotransferase 1 (GFAT1), which belongs to the hexosamine biosynthesis pathway (HBP) that produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to maintain glycoprotein, was validated by evaluation of mRNA and protein levels...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29748707/risk-factors-of-recurrence-in-t1-colorectal-cancers-treated-by-endoscopic-resection-alone-or-surgical-resection-with-lymph-node-dissection
#11
Yuta Kouyama, Shin-Ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Shingo Matsudaira, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Fumio Ishida, Shigeharu Hamatani
PURPOSE: The recurrence of T1 colorectal cancers is relatively rare, and the prognostic factors still remain obscure. This study aimed to clarify the risk factors for recurrence in patients with T1 colorectal cancers treated by endoscopic resection (ER) alone or surgical resection (SR) with lymph node dissection, respectively. METHODS: We reviewed 930 patients with resected T1 colorectal cancers (mean follow-up, 52.3 months). Patients were divided into two groups: those who underwent ER alone (298 cases), and those who underwent initial or additional SR with lymph node dissection (632 cases)...
May 11, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29744201/preventive-effects-of-mouthguard-use-while-sleeping-on-recurrent-aphthous-stomatitis-preliminary-interventional-study
#12
Hidesuke Tada, Natsumi Fujiwara, Takaaki Tsunematsu, Yoshiko Tada, Rieko Arakaki, Naofumi Tamaki, Naozumi Ishimaru, Yasusei Kudo
Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulceration in the oral mucosa of otherwise healthy individuals and is often accompanied by severe pain. However, the etiology of RAS is not completely understood, and currently, no therapy can completely prevent RAS recurrence. In our clinical experience, we noticed that patients using a night guard, which is often used for bruxism treatment, did not develop RAS. Therefore, the aim of this study was to determine whether mouthguard use can suppress RAS development...
October 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29744008/kudos-to-karla-kurrelmeyer-m-d-for-guiding-this-issue-on-women-and-cardiovascular-disease
#13
EDITORIAL
Karla Kurrelmeyer
No abstract text is available yet for this article.
October 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29741543/inhibition-of-homophilic-dimerization-and-disruption-of-cell-adhesion-by-p-cadherin-specific-small-molecules-from-spr-based-assays
#14
Akinobu Senoo, Satoru Nagatoishi, Anna Moberg, Linnea Nygren Babol, Tomoya Mitani, Takumi Tashima, Shota Kudo, Kouhei Tsumoto
The inhibitor for the homophilic dimerization of P-cadherin was discovered by SPR-based screening using fragment compounds. Our SPR assays identified a specific P-cadherin binder, which was able to inhibit the cell adhesion of living CHO cells that expressed P-cadherin.
May 9, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29737476/differential-effects-of-brain-death-on-rat-microcirculation-and-intestinal-inflammation-female-versus-male
#15
Sueli Gomes Ferreira, Roberto Armstrong-Jr, Guilherme Konishi Kudo, Cristiano de Jesus Correia, Sabrina Thalita Dos Reis, Paulina Sannomiya, Ana Cristina Breithaupt-Faloppa, Luiz Felipe Pinho Moreira
Brain death (BD) affects organs by multiple mechanisms related to hemodynamic effects, hormonal changes, and the systemic inflammatory response, which reduce organ function and viability. BD reduces microcirculatory perfusion in rat mesentery; this disturbance is also observed in the pancreas and lungs. Sex hormones can affect microcirculatory function, altering tissue perfusion and influencing the inflammatory process. Here, we present differences between sexes in the microcirculatory alterations generated by BD and in inflammatory infiltrate...
May 8, 2018: Inflammation
https://www.readbyqxmd.com/read/29735610/reduction-in-secretion-of-very-low-density-lipoprotein-triacylglycerol-by-a-matrix-metalloproteinase-inhibitor-in-a-rat-model-of-diet-induced-hypertriglyceridemia
#16
Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai, Naomi Kudo
Matrix metalloproteinase inhibitors (MMPIs) reduced serum triacylglycerol (TAG) levels in streptozotocin-induced diabetic rats and Zucker fa/fa rats in our previous study. However, the mechanisms underlying TAG reduction by MMPIs remain unclear. The present study aimed to elucidate the mechanism by which F81-1144b, a MMPI, lowers serum TAG levels in an animal model of high sucrose diet (HSD)-induced hypertriglyceridemia. F81-1144b was repeatedly administered to rats fed HSD, and its effects were evaluated on TAG levels in serum and the liver, very low density lipoprotein (VLDL) secretion, de novo fatty acid (FA) synthesis in the liver, and the expression of genes regulating the metabolism of FA, TAG, and VLDL in the liver and serum...
May 7, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29734514/immune-checkpoint-blockade-for-the-treatment-of-human-hepatocellular-carcinoma
#17
REVIEW
Naoshi Nishida, Masatoshi Kudo
Hepatocellular carcinoma (HCC) is one of the most common cancers with a high recurrence rate. Currently, tyrosine kinase inhibitors (TKIs) are the first-line treatment for cases refractory to conventional therapies. However, the acquisition of somatic mutations can result in TKI resistance. Clinical evidence suggests that acquired immunity contributes to the suppression of tumor recurrence, indicating the potential of induced anti-tumor immune reaction for the treatment of HCC. Recently, immune checkpoint inhibitors have become available for the treatment of malignancies...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29731999/periostin-attenuates-tumor-growth-by-inducing-apoptosis-in-colitis-related-colorectal-cancer
#18
Yusuke Shimoyama, Keiichi Tamai, Rie Shibuya, Mao Nakamura, Mai Mochizuki, Kazunori Yamaguchi, Yoichi Kakuta, Yoshitaka Kinouchi, Ikuro Sato, Akira Kudo, Tooru Shimosegawa, Kennichi Satoh
Inflammatory bowel diseases, which are multifactorial autoimmune colitis diseases, are occurring with increasing prevalence. One of the most serious complications of these diseases is colorectal cancer. Here we investigated the role of periostin (Postn), a matricellular protein that interacts with various integrin molecules on the cell surface, in colitis-induced colorectal cancer. Immunohistochemistry of mouse and human colorectal cancer samples revealed that Postn was expressed in the stroma and was upregulated in close proximity to the cancer cells...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731920/association-of-iron-metabolic-enzyme-hepcidin-expression-levels-with-the-prognosis-of-patients-with-pancreatic-cancer
#19
Reishi Toshiyama, Masamitsu Konno, Hidetoshi Eguchi, Ayumu Asai, Takehiro Noda, Jun Koseki, Kei Asukai, Tomofumi Ohashi, Katsunori Matsushita, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, possibly through the generation of reactive oxygen species (ROS). Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29730378/vogt-koyanagi-harada-syndrome-induced-by-pembrolizumab-in-a-patient-with-non-small-cell-lung-cancer
#20
Tomoki Tamura, Etsuko Akimoto, Chiaki Matsumoto, Syunta Mori, Tatuya Nishi, Kennichiro Kudo, Syouichi Kuyama
No abstract text is available yet for this article.
May 3, 2018: Journal of Thoracic Oncology
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