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https://www.readbyqxmd.com/read/28088786/ezh2-inhibition-suppresses-endometrial-cancer-progression-via-mir-361-twist-axis
#1
Kei Ihira, Peixin Dong, Ying Xiong, Hidemichi Watari, Yosuke Konno, Sharon Jb Hanley, Masayuki Noguchi, Noriyuki Hirata, Futoshi Suizu, Takahiro Yamada, Masataka Kudo, Noriaki Sakuragi
EZH2 inhibition and reactivation of tumor suppressor microRNAs (miRNAs) represent attractive anti-cancer therapeutic strategies. We found that EZH2-suppressed let 7b and miR-361, two likely tumor suppressors, inhibited endometrial cancer (EC) cell proliferation and invasion, and abrogated cancer stem cell-like properties. In EC cells, EZH2 induced and functioned together with YY1 to epigenetically suppress miR-361, which upregulated Twist, a direct target of miR-361. Treating EC cells with GSK343, a specific EZH2 inhibitor, mimicked the effects of siRNA-mediated EZH2 knockdown, upregulating miR-361 and downregulating Twist expression...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28077905/biomedical-scientific-and-professional-social-networks-in-the-service-of-the-development-of-modern-scientific-publishing
#2
Izet Masic, Edin Begic
Information technologies have found their application in virtually every branch of health care. In recent years they have demonstrated their potential in the development of online library, where scientists and researchers can share their latest findings. Academia.edu, ResearchGate, Mendeley, Kudos, with the support of platform GoogleScholar, have indeed increased the visibility of scientific work of one author, and enable a much greater availability of the scientific work to the broader audience. Online libraries have allowed free access to the scientific content to the countries that could not follow the economic costs of getting access to certain scientific bases...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#3
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28059681/isolation-and-spectral-characterization-of-thermally-generated-multi-z-isomers-of-lycopene-and-the-theoretically-preferred-pathway-to-di-z-isomers
#4
Masaki Honda, Tatsuya Kudo, Takahiro Kuwa, Takuma Higashiura, Tetsuya Fukaya, Yoshinori Inoue, Chitoshi Kitamura, Munenori Takehara
Lycopene has a large number of geometric isomers caused by E/Z isomerization at arbitrary sites within the 11 conjugated double bonds, offering varying characteristics related to features such as antioxidant capacity and bioavailability. However, the geometric structures of only a few lycopene Z-isomers have been thoroughly identified from natural sources. In this study, seven multi-Z-isomers of lycopene, (9Z,13'Z)-, (5Z,13Z,9'Z)-, (9Z,9'Z)-, (5Z,13'Z)-, (5Z,9'Z)-, (5Z,9Z,5'Z)-, and (5Z,9Z)-lycopene, were obtained from tomato samples by thermal isomerization, and then isolated by elaborate chromatography, and fully assigned using proton nuclear magnetic resonance...
February 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28059504/particulate-photocatalyst-sheets-based-on-carbon-conductor-layer-for-efficient-z-scheme-pure-water-splitting-at-ambient-pressure
#5
Qian Wang, Takashi Hisatomi, Yohichi Suzuki, Zhenhua Pan, Jeongsuk Seo, Masao Katayama, Tsutomu Minegishi, Hiroshi Nishiyama, Tsuyoshi Takata, Kazuhiko Seki, Akihiko Kudo, Taro Yamada, Kazunari Domen
Development of sunlight-driven water splitting systems with high efficiency, scalability, and cost-competitiveness is a central issue for mass production of solar hydrogen as a renewable and storable energy carrier. Photocatalyst sheets comprising a particulate hydrogen evolution photocatalyst (HEP) and an oxygen evolution photocatalyst (OEP) embedded in a conductive thin film can realize efficient and scalable solar hydrogen production using Z-scheme water splitting. However, the use of expensive precious metal thin films that also promote reverse reactions is a major obstacle to developing a cost-effective process at ambient pressure...
January 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28056660/biochemical-markers-reflecting-thyroid-function-in-athyreotic-patients-on-levothyroxine-monotherapy
#6
Mitsuru Ito, Akira Miyauchi, Mako Fujiwara, Waka Yoshioka, Akane Ide, Takumi Kudo, Eijun Nishihara, Minoru Kihara, Yasuhiro Ito, Kaoru Kobayashi, Akihiro Miya, Shuji Fukata, Mitsushige Nishikawa, Hirotoshi Nakamura, Nobuyuki Amino
BACKGROUND: Some investigators reported that among athyreotic patients on levothyroxine (LT4) monotherapy following total thyroidectomy, the patients with normal serum thyroid-stimulating hormone (TSH) levels had mildly low serum free triiodothyronine (FT3) levels, whereas the patients with mildly suppressed serum TSH levels had normal serum FT3 levels and the patients with strongly suppressed serum TSH had elevated serum FT3 levels. The objective of the present study was to clarify which of these three patient groups is closer to their preoperative euthyroid condition...
January 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28056587/effects-of-components-of-pm2-5-collected-in-japan-on-the-respiratory-and-immune-systems
#7
Akiko Honda, Wataru Fukushima, Mizuki Oishi, Kenshi Tsuji, Takahiro Sawahara, Tomohiro Hayashi, Hitomi Kudo, Yuji Kashima, Katsuyuki Takahashi, Hideki Sasaki, Kayo Ueda, Hirohisa Takano
Epidemiologic studies have reported that particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) affect respiratory diseases, including asthma. The components and/or factors of PM2.5 that contribute to the exacerbation of asthma have not been identified. We investigated the effects of extracts of PM2.5 collected in Japan on the respiratory and immune systems. PM2.5 was collected from an industrial area and an urban area in December 2013. Airway epithelial cells and immune cells were exposed to aqueous or organic extracts of PM2...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28056459/influence-of-liver-inflammation-on-liver-stiffness-measurement-in-patients-with-autoimmune-hepatitis-evaluation-by-combinational-elastography
#8
Norihisa Yada, Toshiharu Sakurai, Tomohiro Minami, Tadaaki Arizumi, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo
OBJECTIVE: In order to evaluate the influence of liver inflammation on liver stiffness measurement (LSM) by the simultaneous use of shear wave and strain imaging (combinational elastography), shear wave and strain imaging were compared before and after initial therapy for autoimmune hepatitis (AIH). METHODS: Nine AIH patients initially treated with steroid were enrolled. Transient elastography and real-time tissue elastography were performed just before and 1 month after the start of initial steroid treatment...
January 6, 2017: Oncology
https://www.readbyqxmd.com/read/28054649/ameloblastin-induces-tumor-suppressive-phenotype-and-enhances-chemosensitivity-to-doxorubicin-via-src-stat3-inactivation-in-osteosarcoma
#9
Toshinori Ando, Yasusei Kudo, Shinji Iizuka, Takaaki Tsunematsu, Hanako Umehara, Madhu Shrestha, Toshihiro Matsuo, Tadahiko Kubo, Shouji Shimose, Koji Arihiro, Ikuko Ogawa, Mitsuo Ochi, Takashi Takata
Ameloblastin (AMBN), the most abundant non-amelogenin enamel matrix protein, plays a role in ameloblast differentiation. Previously, we found that AMBN promoted osteogenic differentiation via the interaction between CD63 and integrin β1, leading to the inactivation of Src; however, how AMBN affects the malignant behavior of osteosarcoma is still unclear. Osteosarcoma affects the bone and is associated with poor prognosis because of the high rate of pulmonary metastases and drug resistance. Here we demonstrated that stable overexpression of AMBN induced apoptosis and suppressed colony formation and cell migration via the inactivation of Src-Stat3 pathway in human osteosarcoma cells...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052009/cancer-associated-fibroblasts-promote-an-immunosuppressive-microenvironment-through-the-induction-and-accumulation-of-protumoral-macrophages
#10
Hideyuki Takahashi, Koichi Sakakura, Takeshi Kudo, Minoru Toyoda, Kyoichi Kaira, Tetsunari Oyama, Kazuaki Chikamatsu
Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC) in vitro and in human cancer samples. The expression of CD68, CD14, CD163, CD200R, CD206, HLA-G, CD80, and CD86 was higher in CD14-positive cells co-cultured with the culture supernatants of CAFs established from OSCC specimens (CAF-educated cells) than in control cells...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051136/temporal-variation-of-cesium-isotope-concentrations-and-atom-ratios-in-zooplankton-in-the-pacific-off-the-east-coast-of-japan
#11
Takahito Ikenoue, Hyoe Takata, Masashi Kusakabe, Natsumi Kudo, Kazuyuki Hasegawa, Takashi Ishimaru
After the Fukushima Daiichi Nuclear Power Plant accident in March 2011, concentrations of cesium isotopes ((133)Cs, (134)Cs, and (137)Cs) were measured in zooplankton collected in the Pacific off the east coast of Japan from May 2012 to February 2015. The time series of the data exhibited sporadic (137)Cs concentration peaks in zooplankton. In addition, the atom ratio of (137)Cs/(133)Cs in zooplankton was consistently high compared to that in ambient seawater throughout the sampling period. These phenomena cannot be explained fully by the bioaccumulation of (137)Cs in zooplankton via ambient seawater intake, the inclusion of resuspended sediment in the plankton sample, or the taxonomic composition of the plankton...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045050/corrigendum-a-novel-mouse-model-of-intrahepatic-cholangiocarcinoma-induced-by-liver-specific-kras-activation-and-pten-deletion
#12
Tsuneo Ikenoue, Yumi Terakado, Hayato Nakagawa, Yohko Hikiba, Tomoaki Fujii, Daisuke Matsubara, Rei Noguchi, Chi Zhu, Keisuke Yamamoto, Yotaro Kudo, Yoshinari Asaoka, Kiyoshi Yamaguchi, Hideaki Ijichi, Keisuke Tateishi, Noriyoshi Fukushima, Shin Maeda, Kazuhiko Koike, Yoichi Furukawa
No abstract text is available yet for this article.
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045038/disruption-of-cell-adhesion-by-an-antibody-targeting-the-cell-adhesive-intermediate-x-dimer-of-human-p-cadherin
#13
Shota Kudo, Jose M M Caaveiro, Satoru Nagatoishi, Takamitsu Miyafusa, Tadashi Matsuura, Yukio Sudou, Kouhei Tsumoto
Human P-cadherin is a cell adhesion protein of the family of classical cadherins, the overexpression of which is correlated with poor prognosis in various types of cancer. Antibodies inhibiting cell-cell adhesion mediated by P-cadherin show clear therapeutic effect, although the mechanistic basis explaining their effectiveness is still unclear. Based on structural, physicochemical, and functional analyses, we have elucidated the molecular mechanism of disruption of cell adhesion by antibodies targeting human P-cadherin...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040900/theoretical-study-on-reaction-pathways-leading-to-co-and-co2-in-the-pyrolysis-of-resorcinol
#14
Yuki Furutani, Shinji Kudo, Jun-Ichiro Hayashi, Koyo Norinaga
Possible pathways for the pyrolysis of resorcinol with the formation of CO and CO2 as final products were proposed and evaluated using ab initio calculations. Our experimental study revealed that large quantities of CO2 is generated in the pyrolysis of 1,3-dihydroxybenzene (resorcinol) while the pyrolysis of the dihydroxybenzene isomers 1,2-dihydroxybenzene (catechol) and 1,4-dihydroxybenzene (hydroquinone) produces little CO2. The fate of oxygen atoms in catechol and hydroquinone was essentially the formation of CO...
January 1, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28039901/living-donor-liver-transplantation-in-a-pediatric-patient-with-preexisting-yolk-sac-tumor
#15
Taiichi Wakiya, Yoshikazu Toyoki, Keinosuke Ishido, Daisuke Kudo, Norihisa Kimura, Shinji Tsutsumi, Tadashi Odagiri, Akiko Suto, Chiaki Uchida, Kenichi Hakamada
There is ongoing discussion regarding the indications and timing of LT for patients with a preexisting extrahepatic malignancy. We herein report a pediatric case that underwent LDLT after therapy for YST. The patient, a 13-year-old female with biliary atresia, had undergone portoenterostomy at 2 months of age. She developed a left ovarian tumor with a high serum alpha-fetoprotein concentration at 10 years of age. She underwent left oophorectomy and was diagnosed with ovarian YST (Stage I). After surgery, hepatopulmonary syndrome progressed gradually...
December 30, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/28039117/size-dependent-sex-allocation-and-reproductive-investment-in-a-gynodioecious-shrub
#16
Akari Shibata, Gaku Kudo
In sexually dimorphic plants, resource allocation to reproduction often differs between sex morphs. In gynodioecious species, i.e. coexisting hermaphrodite and female plants within a population, females often produce more fruits than hermaphrodites. Since fruit production is costlier than flower production, hermaphrodites and females may regulate flower and fruit production differently in response to resource availability. To clarify the gender-specific strategies of reproductive allocation, we assessed sexual dimorphism in reproductive traits, size-dependent resource allocation, morphological traits, and photosynthetic capacity in a natural population of a gynodioecious shrub, Daphne jezoensis Hermaphrodites had larger flowers and increased flower number with plant size at a rate greater than females, but showed consistently smaller fruit production...
December 30, 2016: AoB Plants
https://www.readbyqxmd.com/read/28036244/viscosity-dependent-variations-in-the-cell-shape-and-swimming-manner-of-leptospira
#17
Kyosuke Takabe, Hajime Tahara, Md Shafiqul Islam, Samia Affroze, Seishi Kudo, Shuichi Nakamura
Spirochetes are spiral or flat-wave-shaped Gram-negative bacteria that have periplasmic flagella (PF) between the peptidoglycan layer and outer membrane. Rotation of the PF transforms the cell body shape periodically, allowing the cell to swim in aqueous environments. Because the virulence of motility-deficient mutants of pathogenic species is drastically attenuated, motility is thought to be an essential virulence factor in spirochetes. However, it remains unknown how motility practically contributes to the infection process...
December 30, 2016: Microbiology
https://www.readbyqxmd.com/read/28031714/temperament-personality-and-treatment-outcome-in-major-depression-a-6-month-preliminary-prospective-study
#18
Yuka Kudo, Atsuo Nakagawa, Taisei Wake, Natsumi Ishikawa, Chika Kurata, Mizuki Nakahara, Teruo Nojima, Masaru Mimura
BACKGROUND: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P's eight constructs on the treatment outcome of depressed patients...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28030864/cd68-positive-cells-in-hepatic-angiomyolipoma
#19
Hitoshi Tochio, Eriko Tamaki, Yukihiro Imai, Nobuhiro Iwasaki, Kazushi Minowa, Hobyung Chung, Yoshiki Suginoshita, Tetsurou Inokuma, Masatoshi Kudo
Four resected specimens of hepatic angiomyolipoma in which uptake of Sonazoid was observed in the postvascular phase of Sonazoid-enhanced ultrasonography were analyzed. Macrophage localization in the tumor was revealed pathologically by immunohistochemical staining for CD68. CD68-positive cells were observed in the tumor in all cases. The density of CD68-positive cells was 100/mm2, and the ratio of CD68-positive cell density in the tumor to that in the surrounding parenchyma was 32-171%. These results suggested that the uptake of the contrast agent Sonazoid was related to the density of CD68-positive cells...
December 29, 2016: Oncology
https://www.readbyqxmd.com/read/28028382/fice-vs-narrow-band-imaging-for-in-vivo-histologic-diagnosis-of-polyps
#20
Cevher Akarsu, Nuri Alper Sahbaz, Ahmet Cem Dural, Mustafa Gokhan Unsal, Osman Kones, Ali Kocatas, Ilkay Halicioglu, Halil Alis
BACKGROUND AND OBJECTIVES: Gastrointestinal cancers are the most frequently occurring cancers worldwide. Diagnosis and removal of polyps during screening endoscopy decreases the prevalence of colon cancer and cancer-related mortality, and it is considered to be the gold standard in gastrointestinal system cancer prevention. Technological innovations in endoscopy have led to revolutionary developments in many areas. Flexible spectral imaging color enhancement (FICE) and narrow-band imaging (NBI) are forms of digital chromoendoscopy and enhance the endoscopic images without the need for a dye...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
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