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https://www.readbyqxmd.com/read/27932229/regorafenib-for-patients-with-hepatocellular-carcinoma-who-progressed-on-sorafenib-treatment-resorce-a-randomised-double-blind-placebo-controlled-phase-3-trial
#1
Jordi Bruix, Shukui Qin, Philippe Merle, Alessandro Granito, Yi-Hsiang Huang, György Bodoky, Marc Pracht, Osamu Yokosuka, Olivier Rosmorduc, Valeriy Breder, René Gerolami, Gianluca Masi, Paul J Ross, Tianqiang Song, Jean-Pierre Bronowicki, Isabelle Ollivier-Hourmand, Masatoshi Kudo, Ann-Lii Cheng, Josep M Llovet, Richard S Finn, Marie-Aude LeBerre, Annette Baumhauer, Gerold Meinhardt, Guohong Han
BACKGROUND: There are no systemic treatments for patients with hepatocellular carcinoma (HCC) whose disease progresses during sorafenib treatment. We aimed to assess the efficacy and safety of regorafenib in patients with HCC who have progressed during sorafenib treatment. METHODS: In this randomised, double-blind, parallel-group, phase 3 trial done at 152 sites in 21 countries, adults with HCC who tolerated sorafenib (≥400 mg/day for ≥20 of last 28 days of treatment), progressed on sorafenib, and had Child-Pugh A liver function were enrolled...
December 5, 2016: Lancet
https://www.readbyqxmd.com/read/27930406/stress-response-protein-rbm3-promotes-the-development-of-colitis-associated-cancer
#2
Toshiharu Sakurai, Hiroshi Kashida, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Tomohiro Watanabe, Masayuki Kitano, Naoshi Nishida, Jun Fujita, Masatoshi Kudo
BACKGROUND: Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and often results from refractory inflammatory bowel disease (IBD). Stress response proteins Cirp and HSPA4 are involved in the refractory clinical course and development of CAC. RNA-binding motif protein 3 (RBM3) is induced in response to various stresses and is upregulated in several cancers. However, the role of RBM3 in CAC is unclear. METHODS: We assessed RBM3 expression and function in 263 human intestinal mucosa samples from patients with IBD and in Rbm3-deficient (Rbm3) mice...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27922334/ionizing-radiation-impairs-endogenous-regeneration-of-infarcted-heart-an-in-vivo-18-f-fdg-pet-ct-and-99m-tc-tetrofosmin-spect-ct-study-in-mice
#3
Lan Luo, Kodai Nishi, Yoshishige Urata, Chen Yan, Al Shaimaa Hasan, Shinji Goto, Takashi Kudo, Zhao-Lan Li, Tao-Sheng Li
Epidemiological studies have suggested that ionizing radiation increases cardiovascular disease risk, but the relevant mechanism is poorly understood. We recently demonstrated that adult mice exposed to whole-body irradiation with 3 Gy gamma rays significantly decreases the number and quality of cardiac stem cells. To further determine if radiation impairs myocardial regenerative potency, a myocardial infarction model was established in adult C57BL/6 mice by ligating the left anterior descending artery approximately 6 h after sham- or whole-body gamma irradiation (0 or 3 Gy)...
December 6, 2016: Radiation Research
https://www.readbyqxmd.com/read/27920980/phagocytized-candida-albicans-in-the-peripheral-blood-smear-of-a-girl-with-crohn-disease
#4
Kiyozumi Suzuki, Takahiro Kudo, Yuji Hirai
No abstract text is available yet for this article.
2017: IDCases
https://www.readbyqxmd.com/read/27919018/trigeminal-nervous-system-sensitization-by-infraorbital-nerve-injury-enhances-responses-in-a-migraine-model
#5
Midori Toyama, Chiho Kudo, Chikako Mukai, Mika Inoue, Aiko Oyamaguchi, Hiroshi Hanamoto, Mitsutaka Sugimura, Hitoshi Niwa
BACKGROUND: Although the peripheral and central sensitizations of trigeminal nervous system may be one of the important factors of migraine, the precise mechanism is not fully understood. In this study, we examined the influence of the sensitization of the second division of the trigeminal nerve (V2) by chronic constriction injury (CCI) of the infraorbital nerve (ION) on migraine headache, using the capsaicin-induced migraine model. METHODS: Male Sprague-Dawley rats were assigned to four groups: (a) sham surgery and topical-dural vehicle application (Sham + Vehicle) group, (b) CCI-ION and topical-dural vehicle application (CCI-ION + Vehicle) group, (c) sham surgery and topical-dural capsaicin application (Sham + Capsaicin) group, (d) CCI-ION and topical-dural capsaicin application (CCI-ION + Capsaicin) group...
November 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27916774/non-islet-cell-tumor-hypoglycemia-caused-by-a-big-insulin-like-growth-factor-ii-producing-hepatocellular-carcinoma-an-autopsy-case-report
#6
Hirohito Naruse, Norihiko Shimoyama, Tsugumi Satoh, Yoshiya Yamamoto, Kazuteru Hatanaka, Taiki Kudo, Masayoshi Ohno, Kazuharu Suzuki, Hajime Hirata, Marina Suzuki
A 73-year-old man with a hepatocellular carcinoma was admitted to our hospital. He suffered from recurrent severe hypoglycemia. An autopsy was performed after his death. Anti-insulin-like growth factor II (IGF-II) monoclonal antibody immunostaining of the hepatocellular carcinoma was positive. Western immunoblot analysis of the serum revealed highly elevated IGF-II. Therefore, we diagnosed this case as a non-islet cell tumor hypoglycemia caused by a big IGF-II-producing hepatocellular carcinoma.
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27916450/dramatic-response-after-functional-hemispherectomy-in-a-patient-with-epileptic-encephalopathy-carrying-a-de-novo-col4a1-mutation
#7
Naomi Hino-Fukuyo, Atsuo Kikuchi, Masaki Iwasaki, Yuko Sato, Yuki Kubota, Tomoko Kobayashi, Tojo Nakayama, Kazuhiro Haginoya, Natsuko Arai-Ichinoi, Tetsuya Niihori, Ryo Sato, Tasuku Suzuki, Hiroki Kudo, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Shigeo Kure
We describe the first case of a successful functional hemispherectomy in a patient with epileptic encephalopathy and a de novo collagen type IV alpha 1 (COL4A1) mutation. A 4-year-old girl was COL4A1 mutation-positive and suffered from drug-resistant epilepsy, hemiplegia, and developmental delay. Magnetic resonance imaging detected no porencephaly, and she had no cataract or renal abnormality. Following a presurgical evaluation for epilepsy, she underwent a functional hemispherectomy. She has been seizure free with no intracranial hemorrhage or other perioperative complications...
December 1, 2016: Brain & Development
https://www.readbyqxmd.com/read/27911345/computing-the-influences-of-different-intraocular-pressures-on-the-human-eye-components-using-computational-fluid-structure-interaction-model
#8
Alireza Karimi, Reza Razaghi, Mahdi Navidbakhsh, Toshihiro Sera, Susumu Kudo
BACKGROUND: Intraocular Pressure (IOP) is defined as the pressure of aqueous in the eye. It has been reported that the normal range of IOP should be within the 10-20 mmHg with an average of 15.50 mmHg among the ophthalmologists. Keratoconus is an anti-inflammatory eye disorder that debilitated cornea unable to reserve the normal structure contrary to the IOP in the eye. Consequently, the cornea would bulge outward and invoke a conical shape following by distorted vision. In addition, it is known that any alterations in the structure and composition of the lens and cornea would exceed a change of the eye ball as well as the mechanical and optical properties of the eye...
November 25, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27909548/microvasculature-of-the-esophagus-and-gastroesophageal-junction-lesson-learned-from-submucosal-endoscopy
#9
REVIEW
Roberta Maselli, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Esperanza Grace Santi, Hiroki Sato, Bu'Hussain Hayee, Shin-Ei Kudo
Advanced therapeutic endoscopy, in particular endoscopic mucosal resection, endoscopic submucosal dissection, per-oral endoscopic myotomy, submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible. Combining these information with advanced diagnostic endoscopy, the esophagus is organized, from the luminal side to outside, into five layers (epithelium, lamina propria with lamina muscularis mucosa, submucosa, muscle layer, adventitia). A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and, at the lower esophageal sphincter (LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; peri-esophageal veins in adventitia...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27904041/fatty-acid-%C3%AE-oxidation-plays-a-key-role-in-regulating-cis-palmitoleic-acid-levels-in-the-liver
#10
Kohei Kawabata, Minako Karahashi, Takeshi Sakamoto, Yukiho Tsuji, Tohru Yamazaki, Mari Okazaki, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima
Different monounsaturated fatty acid (MUFA) species have distinct pathophysiological activities. cis-Palmitoleic acid (16:1n-7) was previously reported to improve insulin sensitivity in animal studies. The proportions of hepatic MUFAs are generally considered to reflect changes in the activities of fatty acid modifications (∆9 desaturation and fatty acid elongation). However, hepatic levels of 16:1n-7 are markedly lower than those of oleic acid (18:1n-9). Nevertheless, no convincing explanation has yet been provided for the low level of 16:1n-7...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27902281/acidicapsa-acidisoli-sp-nov-from-the-acidic-soil-of-a-deciduous-forest
#11
Heizo Matsuo, Chisaki Kudo, Juan Li, Akio Tonouchi
A bacterial strain designated strain SK-11T was isolated from the acidic soil of a deciduous forest in the Shirakami Mountains in Japan. Cells of strain SK-11T were aerobic, non-motile, Gram-stain-negative rods, 0.7-1.0 µm in width and 1.0-1.4 µm in length. The pH range for growth was between 4.0 and 5.5, with an optimum at 5.0. The temperature range for growth was between 10°C and 35°C, with an optimum at around 25-30°C. Strain SK-11T utilized various carbohydrates as growth substrates as well as yeast extract and protein hydrolysates...
November 23, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900226/laparoscopic-extirpation-of-a-schwannoma-in-the-lateral-pelvic-space
#12
Eiji Hidaka, Yasuhiro Ishiyama, Chiyo Maeda, Kenta Nakahara, Shoji Shimada, Shumpei Mukai, Naruhiko Sawada, Fumio Ishida, Shin-Ei Kudo
Schwannomas in the lateral pelvic space are very rare. Here, we report the case of a 48-year-old woman who had a tumor detected in her abdomen by abdominal ultrasonography. Abdominal computed tomography and magnetic resonance imaging revealed a well-defined solid tumor of 65 mm in diameter in the right lateral pelvic space. We performed laparoscopic surgery under a diagnosis of a gastrointestinal tumor or neurogenic tumor. The tumor was safely dissected and freed from the surrounding tissues using sharp and blunt maneuvers...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27894046/characteristic-of-thoron-220-rn-in-environment
#13
REVIEW
Masahiro Hosoda, Hiromi Kudo, Kazuki Iwaoka, Ryohei Yamada, Takahito Suzuki, Yuki Tamakuma, Shinji Tokonami
This paper describes importance of (220)Rn (hereafter thoron) progeny measurement for the dose estimation. Although the spatial distribution of thoron activity concentration strongly depends on the distance from wall surface as an indoor thoron source), a homogeneous distribution was expected to be observed for (212)Pb activity concentration which was one of thoron progeny. Furthermore, the mean equilibrium factor for thoron obtained by the recent measurements in several countries widely ranged from 0.008 to 0...
November 22, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27892544/boron-doped-diamond-semiconductor-electrodes-efficient-photoelectrochemical-co2-reduction-through-surface-modification
#14
Nitish Roy, Yuiri Hirano, Haruo Kuriyama, Pitchaimuthu Sudhagar, Norihiro Suzuki, Ken-Ichi Katsumata, Kazuya Nakata, Takeshi Kondo, Makoto Yuasa, Izumi Serizawa, Tomoaki Takayama, Akihiko Kudo, Akira Fujishima, Chiaki Terashima
Competitive hydrogen evolution and multiple proton-coupled electron transfer reactions limit photoelectrochemical CO2 reduction in aqueous electrolyte. Here, oxygen-terminated lightly boron-doped diamond (BDDL) thin films were synthesized as a semiconductor electron source to accelerate CO2 reduction. However, BDDL alone could not stabilize the intermediates of CO2 reduction, yielding a negligible amount of reduction products. Silver nanoparticles were then deposited on BDDL because of their selective electrochemical CO2 reduction ability...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891244/the-effectiveness-of-regional-cooling-for-paclitaxel-induced-peripheral-neuropathy
#15
Junya Sato, Megumi Mori, Satoru Nihei, Masumi Kumagai, Satoshi Takeuchi, Masahiro Kashiwaba, Kenzo Kudo
BACKGROUND: There are currently no promising therapies available to treat or prevent peripheral neuropathy (PN) induced by anticancer drugs in a cumulative dose-dependent manner. In this study, we investigated the efficacy of regional cooling of hands and feet in preventing paclitaxel (PTX)-induced PN. METHODS: Patients with gynecologic cancer who received a tri-weekly cycle of chemotherapy including PTX at doses of 150-175 mg/m(2) were included in this study. Regional cooling was performed by covering patient hands and feet with cold insulators during PTX administration (regional cooling group)...
2016: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/27876633/classification-of-nuclear-morphology-in-endocytoscopy-of-colorectal-neoplasms
#16
Toyoki Kudo, Shin-Ei Kudo, Yuichi Mori, Kunihiko Wakamura, Masashi Misawa, Takemasa Hayashi, Hideyuki Miyachi, Atsushi Katagiri, Fumio Ishida, Haruhiro Inoue
BACKGROUND AND AIMS: We investigated endocytoscopy (EC) findings that were considered risk factors for colorectal neoplasms and determined whether they could be used as new indices to identify carcinomas with massive submucosal invasion (SM-m) or worse outcomes. METHODS: We performed a multivariate analysis of 8 factors on EC images to determine whether they were associated with SM-m or worse. Based on the results, we divided the EC3a category of the EC classification into low grade or high grade, and investigated the diagnostic accuracy of this subclassification...
November 19, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27875842/through-the-mesh-technique-after-endoscopic-ultrasonography-guided-hepaticogastrostomy-a-novel-re-intervention-method
#17
Kosuke Minaga, Mamoru Takenaka, Takeshi Miyata, Yasuhiro Ueda, Masayuki Kitano, Masatoshi Kudo
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27874269/highly-active-alkaline-earth-metals-and-lanthanum-doped-natao3-photocatalysts-for-co2-reduction-to-form-co-using-water-as-an-electron-donor
#18
Haruka Nakanishi, Kosuke Iizuka, Tomoaki Takayama, Akihide Iwase, Akihiko Kudo
Mg, Ca, Sr, Ba and La-doped NaTaO3 has arisen as highly active photocatalysts for CO2 reduction to form CO using water as an electron donor accompanied by O2 evolution under UV irradiation and bubbling of 1 atmosphere of CO2 when an Ag cocatalyst was loaded on those photocatalysts. CO, H2 and O2 simultaneously formed. The ratio of the number of reacted electrons to that of holes was almost unity. This result indicated that water was consumed as an electron donor. A liquid-phase reduction method for loading of the Ag cocatalyst was superior to photodeposition and impregnation methods...
November 22, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27869532/molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-from-outpatients-in-northern-japan-increasing-tendency-of-st5-st764-mrsa-iia-with-arginine-catabolic-mobile-element
#19
Meiji Soe Aung, Mitsuyo Kawaguchiya, Noriko Urushibara, Ayako Sumi, Masahiko Ito, Kenji Kudo, Shigeo Morimoto, Shino Hosoya, Nobumichi Kobayashi
Arginine catabolic mobile element (ACME) is a genomic island of staphylococcus and is considered to confer enhanced ability to survive and growth on host bacterial cells. ACME has been typically identified in Panton-Valentine Leukocidin (PVL)-positive ST8 methicillin-resistant Staphylococcus aureus (MRSA) with SCCmec type IVa (USA300 clone), and it is also found in other lineages at low frequency. Prevalence and molecular characteristics of PVL(+)and/or ACME(+) MRSA were investigated for 624 clinical isolates collected from outpatients in northern Japan from 2013 to 2014...
November 21, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27869442/-two-autopsy-cases-in-which-previous-surgery-facilitated-the-positive-identification-of-decomposed-bodies
#20
Shogo Kasuda, Risa Kudo, Katsuya Yuui, Hiroko Imai, Masatoshi Nakata, Katsuhiko Hatake
The positive identification of decomposed corpses is often difficult. We describe two autopsy cases in which medical materials, which had been implanted during previous surgical treatments, facilitated positive identification. The discovery of decomposed corpses is increasingly common in Japan, due to the increasing number of lonely deaths. Implanted medical materials and devices may be a useful tool for personal identification in the near future.
2016: Soudní Lékarství
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