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https://www.readbyqxmd.com/read/28212535/integration-of-the-cancer-related-inflammatory-response-as-a-stratifying-biomarker-of-survival-in-hepatocellular-carcinoma-treated-with-sorafenib
#1
Jessica Howell, David J Pinato, Ramya Ramaswami, Tadaaki Arizumi, Carlotta Ferrari, Antonello Gibbin, Michela E Burlone, Giulia Guaschino, Pierluigi Toniutto, James Black, Laura Sellers, Masatoshi Kudo, Mario Pirisi, Rohini Sharma
BACKGROUND AND AIMS: Response to sorafenib is highly variable in hepatocellular carcinoma (HCC). Baseline inflammatory parameters and treatment toxicities may improve survival prediction in patients on sorafenib therapy. RESULTS: 442 patients with advanced stage HCC on sorafenib were recruited (follow-up 5096 person-months at risk). 88% had BCLC stage B or greater HCC and 72.3% had Child-Pugh A cirrhosis. On Cox multivariate regression, previously-treated HCC (HR 0...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212047/multimaterial-decomposition-algorithm-for-the-quantification-of-liver-fat-content-by-using-fast-kilovolt-peak-switching-dual-energy-ct-clinical-evaluation
#2
Tomoko Hyodo, Norihisa Yada, Masatoshi Hori, Osamu Maenishi, Peter Lamb, Kosuke Sasaki, Minori Onoda, Masatoshi Kudo, Teruhito Mochizuki, Takamichi Murakami
Purpose To assess the clinical accuracy and reproducibility of liver fat quantification with the multimaterial decomposition (MMD) algorithm, comparing the performance of MMD with that of magnetic resonance (MR) spectroscopy by using liver biopsy as the reference standard. Materials and Methods This prospective study was approved by the institutional ethics committee, and patients provided written informed consent. Thirty-three patients suspected of having hepatic steatosis underwent non-contrast material-enhanced and triple-phase dynamic contrast-enhanced dual-energy computed tomography (CT) (80 and 140 kVp) and single-voxel proton MR spectroscopy within 30 days before liver biopsy...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28210765/refractory-long-term-cholangitis-after-pancreaticoduodenectomy-a-retrospective-study
#3
Hiroki Ueda, Daisuke Ban, Atsushi Kudo, Takanori Ochiai, Shinji Tanaka, Minoru Tanabe
BACKGROUND: Postoperative cholangitis is one of the major late complications after pancreaticoduodenectomy (PD), and recurrent cholangitis has a negative impact on patients' quality of life. However, detailed reports are scarce. The aim of this study was to investigate the clinical features of postoperative cholangitis after PD. METHODS: Between January 2007 and December 2013, 155 consecutive patients underwent PD. Of these, 113 patients were included in this study...
February 16, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28207966/relationship-between-the-length-of-the-forefoot-bones-and-performance-in-male-sprinters
#4
Takahiro Tanaka, Tadashi Suga, Mitsuo Ohtsuka, Jun Misaki, Yuto Miyake, Shoma Kudo, Akinori Nagano, Tadao Isaka
Although recent studies have reported that the forefoot bones are longer in sprinters than in non-sprinters, these reports included a relatively small number of subjects. Moreover, while computer simulation suggested that longer forefoot bones may contribute to higher sprint performance by enhancing plantar flexor moment during sprinting, the correlation between forefoot bone length and sprint performance in humans has not been confirmed in observational studies. Thus, using a relatively large sample, we compared the length of the forefoot bones between sprinters and non-sprinters...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28202871/the-dramatic-recovery-of-a-patient-with-biguanide-associated-severe-lactic-acidosis-following-thiamine-supplementation
#5
Shigeo Godo, Yoshitaro Yoshida, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency. Diabetic patients taking biguanide may be predisposed to thiamine deficiency, even when there is no evidence of risk factors, and the high-dose administration of thiamine may be essential in the treatment of this otherwise under-recognized disorder...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28202818/-hypoglycemic-hemiplegia
#6
Eriko Sugawara, Yosuke Kudo, Ken Johkura
Hypoglycemia may cause acute hemiplegia. The most common diffusion-weighted MR imaging finding in patients with hypoglycemic hemiplegia is the hyperintense lesion involving the internal capsule, mimicking acute ischemic stroke. Thus, in patients with acute onset hemiplegia, it is important to differentiate hypoglycemia on arrival by immediate blood glucose measurement. It has recently been shown that hypoglycemic brain injury start in large white matter tracts such as internal capsule and spread throughout the whole brain, including the gray matter...
February 2017: Brain and Nerve, Shinkei Kenkyƫ No Shinpo
https://www.readbyqxmd.com/read/28201527/high-dose-of-antibiotic-colistin-induces-oligomerization-of-molecular-chaperone-hsp90
#7
Shuntaro Togashi, Kyosuke Takahashi, Arisa Tamura, Ikumi Toyota, Shiori Hatakeyama, Atsushi Komatsuda, Ikuru Kudo, Erina Sasaki Kudoh, Tomoya Okamoto, Asami Haga, Asuka Miyamoto, Ewa Grave, Taku Sugawara, Hiroaki Shimizu, Hideaki Itoh
No abstract text is available yet for this article.
February 14, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28199675/coil-embolization-for-pulmonary-artery-injury-caused-by-chest-tube-drainage
#8
Shunsuke Shigefuku, Yujin Kudo, Toru Saguchi, Junichi Maeda
No abstract text is available yet for this article.
February 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28188564/usefulness-of-the-echocardiographic-paravertebral-approach-for-the-diagnosis-of-descending-thoracic-aortic-dissection
#9
Shoko Yamaguchi, Hironori Murakami, Tomoko Kudo, Chiharu Otokozawa, Shunsuke Sasaki, Satoshi Yuda, Masanori Nojima
BACKGROUND: Transthoracic echocardiography (TTE) is not recommended as the first-line diagnostic modality for Stanford type B aortic dissection (type-B AD). PURPOSES: The aims of this study were to evaluate the usefulness and factors influencing for the diagnosis of type-B AD using the transthoracic echocardiographic paravertebral approach (PVA). METHODS: We compared the image acquisition rate of descending thoracic aorta (DTA) and the diagnostic rate of type-B AD using TTE versus PVA...
February 10, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/28188370/the-knee-extensor-moment-arm-is-associated-with-performance-in-male-sprinters
#10
Yuto Miyake, Tadashi Suga, Mitsuo Otsuka, Takahiro Tanaka, Jun Misaki, Shoma Kudo, Akinori Nagano, Tadao Isaka
PURPOSE: Although large knee extensor torque contributes to superior sprint performance, previous findings have indicated that the quadriceps cross-sectional area (CSA), a pivotal morphological regulator of knee extensor torque, is not correlated with performance in sprinters. We hypothesized that the knee extensor moment arm (MA), another main morphological regulator of knee extensor torque, may affect sprint performance. To test this hypothesis, we examined the relationship between knee extensor MA and sprint performance...
February 10, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28182699/bifunctional-effects-of-o-methylated-flavones-from-scutellaria-baicalensis-georgi-on-melanocytes-inhibition-of-melanin-production-and-intracellular-melanosome-transport
#11
Michiko Kudo, Kumiko Kobayashi-Nakamura, Kentaro Tsuji-Naito
The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect on melanogenesis; (2) wogonin and its glycoside are the active components of S. baicalensis; and (3) O-methylated flavones from S. baicalensis, such as wogonin, inhibit intracellular melanosome transport...
2017: PloS One
https://www.readbyqxmd.com/read/28172541/p212-location-and-kudo-pit-pattern-reflect-neoplastic-histology-of-lesions-detected-at-surveillance-colonoscopy-in-inflammatory-bowel-disease
#12
M Iacucci, A Oluseyi, R Panaccione, X Gui, S Urbanski, P Minoo, G G Kaplan, K Novak, M W Lowerison, B C Lethebe, Y Leung, C H-T Seow, S Ghosh
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165054/novel-treatment-of-chronic-graft-versus-host-disease-in-mice-using-the-er-stress-reducer-4-phenylbutyric-acid
#13
Shin Mukai, Yoko Ogawa, Fumihiko Urano, Chie Kudo-Saito, Yutaka Kawakami, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a notorious complication of allogeneic hematopoietic stem cell transplantation and causes disabling systemic inflammation and fibrosis. In this novel study, we focused on a relationship between endoplasmic reticulum (ER) stress and cGVHD, and aimed to create effective treatment of cGVHD. A series of experiments were conducted using a mouse model of cGVHD. Our data suggested (1) that ER stress was elevated in organs affected by cGVHD and (2) that 4-phenylbutyric acid (PBA) could reduce cGVHD-induced ER stress and thereby alleviate systemic inflammation and fibrosis...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164191/particulate-photocatalyst-sheets-for-z-scheme-water-splitting-advantages-over-powder-suspension-and-photoelectrochemical-systems-and-future-challenges
#14
Qian Wang, Takashi Hisatomi, Masao Katayama, Tsuyoshi Takata, Tsutomu Minegishi, Akihiko Kudo, Taro Yamada, Kazunari Domen
Water splitting using semiconductor photocatalysts has been attracting growing interest as a means of solar energy based conversion of water to hydrogen, a clean and renewable fuel. Z-scheme photocatalytic water splitting based on the two-step excitation of an oxygen evolution photocatalyst (OEP) and a hydrogen evolution photocatalyst (HEP) is a promising approach toward the utilisation of visible light. In particular, a photocatalyst sheet system consisting of HEP and OEP particles embedded in a conductive layer has been recently proposed as a new means of obtaining efficient and scalable redox mediator-free Z-scheme solar water splitting...
February 6, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28160571/the-oncoprotein-gankyrin-promotes-the-development-of-colitis-associated-cancer-through-activation-of-stat3
#15
Toshiharu Sakurai, Hiroaki Higashitsuji, Hiroshi Kashida, Tomohiro Watanabe, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Masayuki Kitano, Naoshi Nishida, Takaya Abe, Hiroshi Kiyonari, Katsuhiko Itoh, Jun Fujita, Masatoshi Kudo
Although long-standing colonic inflammation due to refractory inflammatory bowel disease (IBD) promotes the development of colitis-associated cancer (CAC), the molecular mechanisms accounting for the development of CAC remains largely unknown. In this study, we investigated the role of gankyrin in the development of CAC since gankyrin is overexpressed in sporadic colorectal cancers. We analyzed gene expression of colon tissues obtained from 344 patients with IBD and CAC and found that expression of gankyrin was much higher in colonic mucosa of patients with refractory IBD than in those with IBD in remission...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28158764/genes-sufficient-for-synthesizing-peptidoglycan-are-retained-in-gymnosperm-genomes-and-mure-from-larix-gmelinii-can-rescue-the-albino-phenotype-of-arabidopsis-mure
#16
Xiaofei Lin, Ningning Li, Hiromi Kudo, Zhe Zhang, Jinyu Li, Li Wang, Wenbo Zhang, Katsuaki Takechi, Hiroyoshi Takano
No abstract text is available yet for this article.
January 31, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28158643/plantexpress-a-database-integrating-oryzaexpress-and-arthaexpress-for-single-species-and-cross-species-gene-expression-network-analyses-with-microarray-based-transcriptome-data
#17
Toru Kudo, Shin Terashima, Yuno Takaki, Ken Tomita, Misa Saito, Maasa Kanno, Koji Yokoyama, Kentaro Yano
No abstract text is available yet for this article.
January 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28155814/nonomuraea-rhodomycinica-sp-nov-isolated-from-peat-swamp-forest-soil-in-thailand
#18
Paranee Sripreechasak, Wongsakorn Phongsopitanun, Khomsan Supong, Pattama Pittayakhajonwut, Takuji Kudo, Moriya Ohkuma, Somboon Tanasupawat
The taxonomic position of actinomycete, strain NR4-ASC07T isolated from soil sample collected from Sirindhorn peat swamp forest, Narathiwat Province, Thailand, was clarified using a polyphasic approach. On the basis of morphological and chemotaxonomic characteristics, it was classified in the members of the genus Nonomuraea. It produced tightly closed spiral spore chains on aerial mycelium as well as forming the pseudosporangium. Whole-cell hydrolysate contained meso-diaminopimelic acid, glucose, ribose, madurose and mannose...
February 2, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28150399/a-combination-of-constitutive-damage-model-and-artificial-neural-networks-to-characterize-the-mechanical-properties-of-the-healthy-and-atherosclerotic-human-coronary-arteries
#19
Alireza Karimi, Seyed Mohammadali Rahmati, Toshihiro Sera, Susumu Kudo, Mahdi Navidbakhsh
It has been indicated that the content and structure of the elastin and collagen of the arterial wall can subject to a significant alteration due to the atherosclerosis. Consequently, a high tissue stiffness, stress, and even damage/rupture are triggered in the arterial wall. Although many studies so far have been conducted to quantify the mechanical properties of the coronary arteries, none of them consider the role of collagen damage of the healthy and atherosclerotic human coronary arterial walls. Recently, a fiber family-based constitutive equation was proposed to capture the anisotropic mechanical response of the healthy and atherosclerotic human coronary arteries via both the histostructural and uniaxial data...
February 2, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28150225/altered-oscillation-of-doppler-derived-renal-and-renal-interlobar-venous-flow-velocities-in-hypertensive-and-diabetic-patients
#20
Yusuke Kudo, Taisei Mikami, Mutsumi Nishida, Kazunori Okada, Sanae Kaga, Nobuo Masauzi, Satomi Omotehara, Hitoshi Shibuya, Kaoru Kahata, Chikara Shimizu
BACKGROUND AND PURPOSE: Flow velocity oscillation rate (FVOR) of the renal interlobar vein has been reported to be decreased in patients with urinary obstruction or diabetic nephropathy, and increased in those with hypertension during pregnancy. To clarify the clinical role of the renal interlobar venous FVOR, we investigated the flow velocity patterns of the renal vessels in patients with hypertension (HT) and/or diabetes (DM). METHODS AND RESULTS: Pulsed-wave Doppler sonography was performed in 34 patients: 15 with HT, 10 with DM, and nine with both HT and DM (HT-DM)...
February 1, 2017: Journal of Medical Ultrasonics
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