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https://www.readbyqxmd.com/read/28277411/testing-for-urinary-tract-infection-in-the-influenza-respiratory-syncytial-virus-positive-febrile-infant-aged-2-to-12-months
#1
Anna Kathleen Schlechter Salinas, David S Hains, Tamekia Jones, Camden Harrell, Mark Meredith
OBJECTIVE: Infants 12 months or younger with influenza and respiratory syncytial virus (RSV) commonly present to the emergency department (ED) with fever. Previous publications have recommended that these patients have a urinalysis and urine culture performed. We aimed to assess the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the ED. We also examined whether the 2011 American Academy of Pediatrics (AAP) UTI clinical practice guidelines could be used to identify patients at lower risk of UTI...
March 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28259698/glycemia-but-not-the-metabolic-syndrome-is-associated-with-cognitive-decline-findings-from-the-european-male-ageing-study
#2
Margot J Overman, Neil Pendleton, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Gianni Forti, Giulia Rastrelli, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, David M Lee, Elon S Correa, Tomas Ahern, Michaël R Laurent, Sabine M P Verschueren, Leen Antonio, Evelien Gielen, Martin K Rutter, Dirk Vanderschueren, Frederick C W Wu, Jos Tournoy
OBJECTIVE: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. METHODS: Over a mean of 4.4 years (SD ± 0...
February 7, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28259047/the-tripartite-leader-sequence-is-required-for-ectopic-expression-of-hadv-b-and-hadv-e-e3-cr1-genes
#3
Camden R Bair, Poornima Kotha Lakshmi Narayan, Adriana E Kajon
The unique repertoire of genes that characterizes the early region 3 (E3) of the different species of human adenovirus (HAdV) likely contributes to their distinct pathogenic traits. The function of many E3 CR1 proteins remains unknown possibly due to unidentified intrinsic properties that make them difficult to express ectopically. This study shows that the species HAdV-B- and HAdV-E-specific E3 CR1 genes can be expressed from vectors carrying the HAdV tripartite leader (TPL) sequence but not from traditional mammalian expression vectors...
March 1, 2017: Virology
https://www.readbyqxmd.com/read/28240251/development-of-a-pipeline-for-automated-high-throughput-analysis-of-paraspeckle-proteins-reveals-specific-roles-for-importin-%C3%AE-proteins
#4
Andrew T Major, Yoichi Miyamoto, Camden Y Lo, David A Jans, Kate L Loveland
We developed a large-scale, unbiased analysis method to measure how functional variations in importin (IMP) α2, IMPα4 and IMPα6 each influence PSPC1 and SFPQ nuclear accumulation and their localization to paraspeckles. This addresses the hypothesis that individual IMP protein activities determine cargo nuclear access to influence cell fate outcomes. We previously demonstrated that modulating IMPα2 levels alters paraspeckle protein 1 (PSPC1) nuclear accumulation and affects its localization into a subnuclear domain that affects RNA metabolism and cell survival, the paraspeckle...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225662/redesigning-school-nursing-education-in-new-jersey-to-address-the-challenges-and-opportunities-of-population-health
#5
Robin M Cogan, Sharon M Conway, Joy D Atkins
School health is a specialty practice of nursing positioned at the intersection of public health and population health. This article discusses the redesign of a program's curriculum with the hope of advancing and elevating the practice of school nursing. The redesign is based on NASN's Framework for 21st Century School Nursing Practice and is the result of a New Jersey Nursing Initiative grant awarded to a trio of adjunct faculty from Rutgers University Camden in July 2016.
March 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28223228/drug-discovery-using-induced-pluripotent-stem-cell-models-of-neurodegenerative-and-ocular-diseases
#6
REVIEW
Sandy S C Hung, Shahnaz Khan, Camden Y Lo, Alex W Hewitt, Raymond C B Wong
The revolution of induced pluripotent stem cell (iPSC) technology provides a platform for development of cell therapy, disease modeling and drug discovery. Recent technological advances now allow us to reprogram a patient's somatic cells into induced pluripotent stem cells (iPSCs). Together with methods to differentiate these iPSCs into disease-relevant cell types, we are now able to model disease in vitro using iPSCs. Importantly, this represents a robust in vitro platform using patient-specific cells, providing opportunity for personalized precision medicine...
February 14, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28194822/autophagy-regulation-of-physiological-and-pathological-processes-in-the-female-reproductive-tract
#7
Bin Cao, Alison J Camden, Lindsay A Parnell, Indira U Mysorekar
Autophagy is a ubiquitous cell recycling pathway that delivers cytoplasmic constituents to the lysosome and is essential for normal cellular function. Autophagic activity is up-regulated under physiological conditions as well as stressful conditions such as nutrient deprivation, oxidative stress, hypoxia, inflammation, and infection. Thus, it is essential to regard the functional importance of the pathway and its components in a given tissue context. Here we review what is known about the involvement of autophagy process during physiological processes in the female reproductive tract and in pregnancy from preimplantation to oocyte function to placental development, parturition, and postpartum remodeling of the uterus; as well as in pathological and adverse events during these processes...
February 13, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28056909/active-travel-to-non-school-destinations-but-not-to-school-is-associated-with-higher-physical-activity-levels-in-an-ethnically-diverse-sample-of-inner-city-schoolchildren
#8
Lee Smith, Daniel Aggio, Mark Hamer
BACKGROUND: This study investigated the association of travel mode to school and non-school destinations with objectively assessed health markers and physical activity in an ethnically diverse sample of inner-city UK schoolchildren. METHODS: We used data from the Camden Active Spaces project (n = 450 children aged 9.1 yrs) to examine associations of school travel mode and frequency of active travel to non-school destinations with daily and out-of-school physical activity, sedentary time and health markers; whilst controlling for appropriate covariates including objectively measured route length...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28051297/source-apportionment-of-atmospheric-polychlorinated-biphenyls-in-new-jersey-1997-2011
#9
Pornsawai Praipipat, Qingyu Meng, Robert J Miskewitz, Lisa A Rodenburg
Concentrations of polychlorinated biphenyls (PCBs) in the Delaware River currently exceed the Water Quality Criteria of 16 pg/L for the sum of PCBs due in part to atmospheric deposition. The purpose of this work was to use a source apportionment tool called Positive Matrix Factorization (PMF) to identify the sources of PCBs to the atmosphere in this area and determine whether their concentrations are declining over time. The data set was compiled by the Delaware Atmospheric Deposition Network (DADN) from samples taken in Camden, NJ from 1999 to 2011 and New Brunswick, NJ from 1997 to 2011...
January 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28026700/how-are-canadian-universities-training-and-supporting-undergraduate-medical-physiotherapy-and-occupational-therapy-students-for-global-health-experiences-in-international-low-resource-settings
#10
Jennifer Bessette, Chantal Camden
OBJECTIVES: Canadian medical (MD), physiotherapy (PT) and occupational therapy (OT) students increasingly show an interest in global health experiences (GHEs). As certain moral hazards can occur as a result of student GHEs, a growing consensus exists that universities must have an established selection process, in-depth pre-departure training (PDT), adequate onsite supervision and formal debriefing for their students. This study aimed to identify current practices in Canadian MD, PT and OT programs and discuss areas for improvement by comparing them with recommendations found in the literature...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27993527/use-of-electric-field-sensors-for-recording-respiration-heart-rate-and-stereotyped-motor-behaviors-in-the-rodent-home-cage
#11
Donald J Noble, Camden J MacDowell, Michael L McKinnon, Tamra I Neblett, William N Goolsby, Shawn Hochman
BACKGROUND: Numerous environmental and genetic factors can contribute significantly to behavioral and cardiorespiratory variability observed experimentally. Affordable technologies that allow for noninvasive home cage capture of physio-behavioral variables should enhance understanding of inter-animal variability including after experimental interventions. NEW METHOD: We assessed whether EPIC electric field sensors (Plessey Semiconductors) embedded within or attached externally to a rodent's home cage could accurately record respiration, heart rate, and motor behaviors...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27979719/admission-to-acute-mental-health-services-after-contact-with-crisis-resolution-and-home-treatment-teams-an-investigation-in-two-large-mental-health-care-providers
#12
Nomi Werbeloff, Chin-Kuo Chang, Matthew Broadbent, Joseph F Hayes, Robert Stewart, David P J Osborn
BACKGROUND: Crisis resolution and home treatment teams (CRTs) offer an alternative to hospital admission for patients undergoing mental health crises in the UK. Few studies have been done to examine predictors of relapse and readmission after contact with CRTs. METHODS: We used the Clinical Record Interactive Search to identify all patients receiving care from CRTs in two National Health Service (NHS) mental health trusts in London: Camden and Islington NHS Foundation Trust and South London and Maudsley NHS Foundation Trust...
January 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/27973765/long-cycling-aqueous-organic-redox-flow-battery-aorfb-toward-sustainable-and-safe-energy-storage
#13
Bo Hu, Camden DeBruler, Zayn Rhodes, T Leo Liu
Redox flow batteries (RFBs) are a viable technology to store renewable energy in the form of electricity that can be supplied to electricity grids. However, widespread implementation of traditional RFBs, such as vanadium and Zn-Br2 RFBs, is limited due to a number of challenges related to materials, including low abundance and high costs of redox-active metals, expensive separators, active material crossover, and corrosive and hazardous electrolytes. To address these challenges, we demonstrate a neutral aqueous organic redox flow battery (AORFB) technology utilizing a newly designed cathode electrolyte containing a highly water-soluble ferrocene molecule...
January 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27940197/delivery-vehicle-effects-on-bone-regeneration-and-heterotopic-ossification-induced-by-high-dose-bmp-2
#14
Laxminarayanan Krishnan, Lauren B Priddy, Camden Esancy, Brett S Klosterhoff, Hazel Y Stevens, Lisa Tran, Robert E Guldberg
Bone morphogenetic protein-2 (BMP-2), delivered on absorbable collagen sponge, is frequently used to treat bone defects. However, supraphysiological BMP-2 doses are common and often associated with complications such as heterotopic ossification and inflammation, causing pain and impaired mobility. This has prompted investigations into strategies to spatially control bone regeneration, for example growth factor delivery in appropriate scaffolds. Our objective was to investigate the spatiotemporal effects of high dose BMP-2 on bone regeneration as a function of the delivery vehicle...
February 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27932937/effect-of-electrolyzed-high-ph-alkaline-water-on-blood-viscosity-in-healthy-adults
#15
RANDOMIZED CONTROLLED TRIAL
Joseph Weidman, Ralph E Holsworth, Bradley Brossman, Daniel J Cho, John St Cyr, Gregory Fridman
BACKGROUND: Previous research has shown fluid replacement beverages ingested after exercise can affect hydration biomarkers. No specific hydration marker is universally accepted as an ideal rehydration parameter following strenuous exercise. Currently, changes in body mass are used as a parameter during post-exercise hydration. Additional parameters are needed to fully appreciate and better understand rehydration following strenuous exercise. This randomized, double-blind, parallel-arm trial assessed the effect of high-pH water on four biomarkers after exercise-induced dehydration...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27928226/achieving-timely-percutaneous-reperfusion-for-rural-st-elevation-myocardial-infarction-patients-by-direct-transport-to-an-urban-pci-hospital
#16
Charles-Lwanga K Bennin, Saif Ibrahim, Farah Al-Saffar, Lyndon C Box, Joel A Strom
BACKGROUNDS: ST-elevation myocardial infarction (STEMI) guidelines recommend reperfusion by primary percutaneous coronary intervention (PCI) ≤ 90 min from time of first medical contact (FMC). This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service (EMS) STEMI field triage protocol...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27920388/human-drivers-of-ecological-and-evolutionary-dynamics-in-emerging-and-disappearing-infectious-disease-systems
#17
REVIEW
Mary A Rogalski, Camden D Gowler, Clara L Shaw, Ruth A Hufbauer, Meghan A Duffy
Humans have contributed to the increased frequency and severity of emerging infectious diseases, which pose a significant threat to wild and domestic species, as well as human health. This review examines major pathways by which humans influence parasitism by altering (co)evolutionary interactions between hosts and parasites on ecological timescales. There is still much to learn about these interactions, but a few well-studied cases show that humans influence disease emergence every step of the way. Human actions significantly increase dispersal of host, parasite and vector species, enabling greater frequency of infection in naive host populations and host switches...
January 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27893601/reducing-missed-opportunities-pairing-sexually-transmitted-infection-screening-with-syringe-exchange-services
#18
Alexis M Roth, Jesse L Goldshear, Ana P Martinez-Donate, Seth Welles, Martha Chavis, Barbara Van Der Pol
About 17.5% of sexually active injection drug users recruited from a syringe exchange in Camden, NJ (n = 120) screened positive for chlamydia/gonorrhea. Among these cases, 40% were detected via extragenital screening. This pilot demonstrates that colocating sexually transmitted infection control with syringe exchange leads to sexually transmitted infection case finding.
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27863735/validity-and-reliability-of-the-functional-dexterity-test-in-children
#19
Camden M Tissue, Paul F Velleman, Caroline W Stegink-Jansen, Dorit Haenosh Aaron, Barbara G Winthrop, Gloria R Gogola
STUDY DESIGN: Clinical measurement study. INTRODUCTION: The Functional Dexterity Test (FDT) has not been validated in children. PURPOSE OF THE STUDY: To determine reliability and validity of the FDT in a pediatric population. METHODS: Intraclass Correlation Coefficients (ICCs) were used to calculate interrater and test-retest reliability in typically developing children. Pearson correlation coefficients were used to compare FDT speed with the Jebsen-Taylor Hand Function Test (JHFT) and with 2 activities of daily living tasks to establish validity in children with congenital hand differences...
November 15, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27863322/sleep-patterns-and-problems-among-early-adolescents-associations-with-alcohol-use
#20
Naomi R Marmorstein
INTRODUCTION: Sleep and sleep-related problems are associated with alcohol use and related problems among adults. However, existing research on associations between sleep and alcohol use among early adolescents is minimal, and potential individual and family factors that may affect this association remain largely unexplored. We examined potential associations between frequency of alcohol use and initial insomnia, subjective daytime sleepiness, sleep irregularity, and disturbed sleep among a low-income, ethnic minority sample of early adolescents; we also considered whether psychopathology symptoms and/or parental monitoring accounted for any associations found...
March 2017: Addictive Behaviors
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