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https://www.readbyqxmd.com/read/29774798/book-review-martin-halliwell-voices-of-mental-health-medicine-politics-and-american-culture-1970-2000-halliwell-martin-voices-of-mental-health-medicine-politics-and-american-culture-1970-2000-rutgers-university-press-new-brunswick-camden-newark-nj-and-london
#1
https://www.readbyqxmd.com/read/29729818/long-term-patient-reported-outcomes-following-acetabular-fracture-fixation
#2
Diederik O Verbeek, Jelle P van der List, Camden M Tissue, David L Helfet
INTRODUCTION: Patient reported outcome scores may be the preferred method to assess clinical results following acetabular fracture fixation. However, in current acetabular fracture research, there is a scarcity of studies using these scores and long-term follow-up is lacking. The aim of this study is to describe long-term patient reported outcomes following acetabular fracture surgery and to evaluate the association between reduction quality and these outcome measures. METHODS: Patients who received operative fixation for acetabular fractures (1992-2012) were sent questionnaires (short musculoskeletal functional assessment (SMFA) function index and short form (SF)-12), which was returned by 106 patients (22%) (mean age 51 years, 74% male)...
April 27, 2018: Injury
https://www.readbyqxmd.com/read/29714167/virological-and-immunological-responses-to-raltegravir-and-dolutegravir-in-the-gut-associated-lymphoid-tissue-of-hiv-infected-men-and-women
#3
Michael D Weber, Elizabeth Andrews, Heather A Prince, Craig Sykes, Elias P Rosen, Camden Bay, Nicholas J Shaheen, Ryan D Madanick, Evan S Dellon, Kristina De Paris, Julie Ae Nelson, Cynthia L Gay, Angela Dm Kashuba
BACKGROUND: Raltegravir (RTG) and dolutegravir (DTG) have different pharmacokinetic patterns in the gastrointestinal tract. To determine if this results in pharmacodynamic differences, we compared HIV RNA, HIV DNA, and immunological markers in gut-associated lymphoid tissue (GALT) of HIV-infected participants receiving RTG or DTG with tenofovir+emtricitabine (TDF/FTC). METHODS: GALT specimens from the terminal ileum, splenic flexure, and rectum were obtained by colonoscopy at a single time point in 20 adults treated with RTG (n=10) or DTG (n=10) with HIV RNA <50 copies/mL...
May 1, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29547340/sers-sensors-recent-developments-and-a-generalized-classification-scheme-based-on-the-signal-origin
#4
Xin Gu, Michael J Trujillo, Jacob E Olson, Jon P Camden
Owing to its extreme sensitivity and easy execution, surface-enhanced Raman spectroscopy (SERS) now finds application for a wide variety of problems requiring sensitive and targeted analyte detection. This widespread application has prompted a proliferation of different SERS-based sensors, suggesting the need for a framework to classify existing methods and guide the development of new techniques. After a brief discussion of the general SERS modalities, we classify SERS-based sensors according the origin of the signal...
March 16, 2018: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/29511363/application-of-a-causal-discovery-algorithm-to-the-analysis-of-arthroplasty-registry-data
#5
REVIEW
Camden Cheek, Huiyong Zheng, Brian R Hallstrom, Richard E Hughes
Improving the quality of care for hip arthroplasty (replacement) patients requires the systematic evaluation of clinical performance of implants and the identification of "outlier" devices that have an especially high risk of reoperation ("revision"). Postmarket surveillance of arthroplasty implants, which rests on the analysis of large patient registries, has been effective in identifying outlier implants such as the ASR metal-on-metal hip resurfacing device that was recalled. Although identifying an implant as an outlier implies a causal relationship between the implant and revision risk, traditional signal detection methods use classical biostatistical methods...
2018: Biomedical Engineering and Computational Biology
https://www.readbyqxmd.com/read/29496398/a-census-of-midsize-to-large-supermarkets-in-toronto-a-cross-sectional-analysis-of-the-consumer-nutrition-environment
#6
Andi Camden, Jennifer Levy, Kate Bassil, Loren Vanderlinden, Olanna White Barnett, Leia M Minaker, Kate Mulligan, Monica Campbell
OBJECTIVE: Assess the consumer nutrition environment in midsize to large supermarkets by supermarket type and area-level socioeconomic variables. DESIGN: Cross-sectional census of 257 supermarkets using the Toronto Nutrition Environment Measures Survey in Stores. SETTING: Toronto, Canada. VARIABLES MEASURED: Availability; price and linear shelf space of fruits and vegetables vs energy-dense snack foods by supermarket type; after-tax, low-income measure; and neighborhood improvement area...
February 26, 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29472964/functional-outcomes-of-thoracolumbar-junction-spine-fractures
#7
Bradford A Wall, Alan Moskowitz, M Camden Whitaker, Teresa L Jones, Ryan M Stuckey, Catherine L Carr-Maben, Alexander Cm Chong
Introduction: Few studies have evaluated the functional outcomes of traumatic thoracic and lumbar vertebral body fractures. This study evaluated the functional and clinical outcomes of patients, who sustained a fracture to the thoracolumbar area of the spine (T10 to L2 region), with ≥ 25° kyphosis versus those with less kyphotic curvature. Methods: The trauma registry records of two level 1 trauma centers using ICD-9 codes for fracture to the thoracolumbar juncture (T10 to L2 region) were reviewed...
May 2017: Kansas Journal of Medicine
https://www.readbyqxmd.com/read/29467472/effector-cd4-t-cells-recognize-intravascular-antigen-presented-by-patrolling-monocytes
#8
Clare L V Westhorpe, M Ursula Norman, Pam Hall, Sarah L Snelgrove, Michaela Finsterbusch, Anqi Li, Camden Lo, Zhe Hao Tan, Songhui Li, Susan K Nilsson, A Richard Kitching, Michael J Hickey
Although effector CD4+ T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4+ T cells undergo intravascular migration within uninflamed glomeruli. Similarly, while MHCII is not expressed by intrinsic glomerular cells, intravascular MHCII-expressing immune cells patrol glomerular capillaries, interacting with CD4+ T cells. Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29467127/quantitative-analysis-of-immune-infiltrates-in-primary-melanoma
#9
Robyn D Gartrell, Douglas K Marks, Thomas D Hart, Gen Li, Danielle R Davari, Alan Wu, Zoë Blake, Yan Lu, Kayleigh N Askin, Anthea Monod, Camden L Esancy, Edward C Stack, Dan Tong Jia, Paul M Armenta, Yichun Fu, Daisuke Izaki, Bret Taback, Raul Rabadan, Howard L Kaufman, Charles G Drake, Basil A Horst, Yvonne M Saenger
Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (qmIF) allows for evaluation of the TME using multiparameter phenotyping, tissue segmentation, and quantitative spatial analysis (qSA). Given that CD3+ CD8+ cytotoxic lymphocytes (CTLs) promote antitumor immunity, whereas CD68+ macrophages impair immunity, we hypothesized that quantification and spatial analysis of macrophages and CTLs would correlate with clinical outcome...
April 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29465703/an-exploration-of-factors-impacting-preexposure-prophylaxis-eligibility-and-access-among-syringe-exchange-users
#10
Alexis M Roth, Brenna L Aumaier, Marisa A Felsher, Seth L Welles, Ana P Martinez-Donate, Martha Chavis, Barbara Van Der Pol
BACKGROUND: In 2015, approximately 50,000 new HIV infections occurred in the United States, 2,400 of which were attributable to injection drug use. Preexposure prophylaxis (PrEP) has the potential to curb HIV acquisition; however, uptake remains low among persons who inject drugs (PWID). The purpose of the study is to describe PrEP eligibility, willingness to use PrEP, and ability to access PrEP among PWID recruited from a pilot program that paired screening and treatment of sexually transmitted infections with mobile syringe exchange program (SEP) services...
April 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29426299/the-delirium-and-population-health-informatics-cohort-study-protocol-ascertaining-the-determinants-and-outcomes-from-delirium-in-a-whole-population
#11
Daniel Davis, Sarah Richardson, Joanne Hornby, Helen Bowden, Katrin Hoffmann, Maryse Weston-Clarke, Fenella Green, Nishi Chaturvedi, Alun Hughes, Diana Kuh, Elizabeth Sampson, Ruth Mizoguchi, Khai Lee Cheah, Melanie Romain, Abhi Sinha, Rodric Jenkin, Carol Brayne, Alasdair MacLullich
BACKGROUND: Delirium affects 25% of older inpatients and is associated with long-term cognitive impairment and future dementia. However, no population studies have systematically ascertained cognitive function before, cognitive deficits during, and cognitive impairment after delirium. Therefore, there is a need to address the following question: does delirium, and its features (including severity, duration, and presumed aetiologies), predict long-term cognitive impairment, independent of cognitive impairment at baseline? METHODS: The Delirium and Population Health Informatics Cohort (DELPHIC) study is an observational population-based cohort study based in the London Borough of Camden...
February 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29397874/prevalence-of-operator-fatigue-in-winter-maintenance-operations
#12
Matthew C Camden, Alejandra Medina-Flintsch, Jeffrey S Hickman, James Bryce, Gerardo Flintsch, Richard J Hanowski
Similar to commercial motor vehicle drivers, winter maintenance operators are likely to be at an increased risk of becoming fatigued while driving due to long, inconsistent shifts, environmental stressors, and limited opportunities for sleep. Despite this risk, there is little research concerning the prevalence of winter maintenance operator fatigue during winter emergencies. The purpose of this research was to investigate the prevalence, sources, and countermeasures of fatigue in winter maintenance operations...
February 2, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29380961/experiences-of-a-patient-initiated-self-monitoring-service-in-inflammatory-arthritis-a-qualitative-exploration
#13
Hayley McBain, Stanton Newman, Michael Shipley, Abigail Olaleye, Samantha Moore
OBJECTIVES: The aim of the present study was to explore patients' experience of a patient-initiated self-monitoring service for people with rheumatoid or psoriatic arthritis who are on methotrexate. METHODS: The study took the form of qualitative semi-structured interviews, embedded within a randomized controlled trial. Twelve participants who were randomly assigned to the intervention arm were interviewed. Interviews digitally, transcribed verbatim and analysed using inductive thematic analysis...
January 30, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29377897/the-camden-islington-research-database-using-electronic-mental-health-records-for-research
#14
Nomi Werbeloff, David P J Osborn, Rashmi Patel, Matthew Taylor, Robert Stewart, Matthew Broadbent, Joseph F Hayes
BACKGROUND: Electronic health records (EHRs) are widely used in mental health services. Case registers using EHRs from secondary mental healthcare have the potential to deliver large-scale projects evaluating mental health outcomes in real-world clinical populations. METHODS: We describe the Camden and Islington NHS Foundation Trust (C&I) Research Database which uses the Clinical Record Interactive Search (CRIS) tool to extract and de-identify routinely collected clinical information from a large UK provider of secondary mental healthcare, and demonstrate its capabilities to answer a clinical research question regarding time to diagnosis and treatment of bipolar disorder...
2018: PloS One
https://www.readbyqxmd.com/read/29369269/developing-a-web-platform-to-support-a-community-of-practice-a-mixed-methods-study-in-pediatric-physiotherapy
#15
Gabrielle Pratte, Karen Hurtubise, Lisa Rivard, Jade Berbari, Chantal Camden
INTRODUCTION: Web platforms are increasingly used to support virtual interactions between members of communities of practice (CoP). However, little is known about how to develop these platforms to support the implementation of best practices for health care professionals. The aim of this article is to explore pediatric physiotherapists' (PTs) perspectives regarding the utility and usability of the characteristic of a web platform developed to support virtual communities of practice (vCoP)...
January 19, 2018: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29359183/maternal-hiv-1-env-vaccination-for-systemic-and-breast-milk-immunity-to-prevent-oral-shiv-acquisition-in-infant-macaques
#16
Joshua A Eudailey, Maria L Dennis, Morgan E Parker, Bonnie L Phillips, Tori N Huffman, Camden P Bay, Michael G Hudgens, Roger W Wiseman, Justin J Pollara, Genevieve G Fouda, Guido Ferrari, David J Pickup, Pamela A Kozlowski, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar
Mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) contributes to an estimated 150,000 new infections annually. Maternal vaccination has proven safe and effective at mitigating the impact of other neonatal pathogens and is one avenue toward generating the potentially protective immune responses necessary to inhibit HIV-1 infection of infants through breastfeeding. In the present study, we tested the efficacy of a maternal vaccine regimen consisting of a modified vaccinia virus Ankara (MVA) 1086...
January 2018: MSphere
https://www.readbyqxmd.com/read/29355314/n-heterocyclic-carbenes-as-a-robust-platform-for-surface-enhanced-raman-spectroscopy
#17
Joseph F DeJesus, Michael J Trujillo, Jon P Camden, David M Jenkins
Surface-enhanced Raman spectroscopy (SERS) underpins a wide range of commercial and fundamental applications. SERS often relies on ligands, usually thiols, bound to a noble metal surface. The difficulty of straightforward thiol synthesis combined with their instability on surfaces highlights the need for alternative ligand design. We present the first example of SERS utilizing N-heterocyclic carbene ligands. A general three step synthesis is presented for functionalized NHC-CO2 adducts. These ligands are deposited on SERS-active gold film-over-nanosphere substrates (AuFONs) in solvent-free and base-free conditions, which prevents fouling...
January 31, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29350143/adenovirus-type-4-respiratory-infections-among-civilian-adults-northeastern-united-states-2011-2015-1
#18
Adriana E Kajon, Daryl M Lamson, Camden R Bair, Xiaoyan Lu, Marie L Landry, Marilyn Menegus, Dean D Erdman, Kirsten St George
Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29314843/multipolar-nanocube-plasmon-mode-mixing-in-finite-substrates
#19
Charles Cherqui, Guoliang Li, Jacob A Busche, Steven C Quillin, Jon P Camden, David J Masiello
Facile control of the radiative and nonradiative properties of plasmonic nanostructures is of practical importance to a wide range of applications in the biological, chemical, optical, information, and energy sciences. For example, the ability to easily tune not only the plasmon spectrum but also the degree of coupling to light and/or heat, quality factor, and optical mode volume would aid the performance and function of nanophotonic devices and molecular sensors that rely upon plasmonic elements to confine and manipulate light at nanoscopic dimensions...
February 1, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29297959/p2y-2-r-deletion-ameliorates-sialadenitis-in-il-14%C3%AE-transgenic-mice
#20
L T Woods, J M Camden, M G Khalafalla, M J Petris, L Erb, J L Ambrus, G A Weisman
OBJECTIVE: Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and hyposalivation. The P2Y2 receptor (P2Y2 R) for extracellular ATP and UTP is upregulated during salivary gland inflammation (i.e., sialadenitis) where it regulates numerous inflammatory responses. This study investigated the role of P2Y2 Rs in autoimmune sialadenitis in the IL-14αTG mouse model of Sjögren's syndrome...
January 3, 2018: Oral Diseases
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