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Victoria L Mayer, Candace R Young, Carolyn C Cannuscio, Allison Karpyn, Sarah Kounaves, Emily Strupp, Kevin McDonough, Judy A Shea
INTRODUCTION: Urban corner store interventions have been implemented to improve access to and promote purchase of healthy foods. However, the perspectives of store owners and managers, who deliver and shape these interventions in collaboration with nonprofit, government, and academic partners, have been largely overlooked. We sought to explore the views of store owners and managers on the role of their stores in the community and their beliefs about health problems and solutions in the community...
October 13, 2016: Preventing Chronic Disease
Jennifer Chi Lo, Anne E O'Connor, Zane B Andrews, Camden Lo, Tony Tiganis, Matthew J Watt, Moira K O'Bryan
Fatty liver, or hepatic steatosis, is an alarmingly common pathology in western societies, in large part because if left unheaded it can lead to life-threatening forms of non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. As such, it is essential that we attain a greater understanding of the pathways that control energy partitioning in the liver, and ultimately how they are impacted by environmental factors. Herein, we define the essential requirement for a member of the RAB-like clade of small GTPases, RABL2, in fatty acid metabolism including in microtubule-associated mitochondrial movement within the liver...
October 12, 2016: Endocrinology
Nicholas Manolios, Marina Ali, Bradley Camden, Elham Aflaky, Katrina Pavic, Andrew Markewycz, Robert De Costa, Socrates Angelides
OBJECTIVE: To evaluate the clinical utility of a novel radiotracer, (99m)Tc-glucosamine, in assessing disease activity of both rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Material and Methods: Twenty-five patients with RA (nine males and 16 females) and 12 patients with AS (all male) at various stages of disease were recruited for the study. A clinical history and examination was performed, followed by the measurement of hematological, biochemical, and autoimmune serological parameters to assess disease activity...
June 2016: Eur J Rheumatol
Charles Cherqui, Yueying Wu, Guoliang Li, Steven C Quillin, Jacob A Busche, Niket Thakkar, Claire A West, Nicholas P Montoni, Philip D Rack, Jon P Camden, David J Masiello
Negative-index metamaterials composed of magnetic plasmon oligomers are actively being investigated for their potential role in optical cloaking, superlensing, and nanolithography applications. A significant improvement to their practicality lies in the ability to function at multiple distinct wavelengths in the visible part of spectrum. Here we utilize the nanometer spatial-resolving power of electron energy-loss spectroscopy to conclusively demonstrate hybridization of magnetic plasmons in oligomer dimers that can achieve this goal...
October 12, 2016: Nano Letters
Jayci E Knights, Michelle L Salvatore, Gunda Simpkins, Krystal Hunter, Meena Khandelwal
BACKGROUND: Postpartum depression (PPD) causes significant morbidity in postpartum women and their newborns. Universal screening is mandated in many states despite little information on optimal interval and frequency of screening. OBJECTIVE: The objective of this study was to determine whether the early Edinburgh Postnatal Depression Scale (EPDS) score (done within 96h after delivery) is predictive of the late EPDS score (done at outpatient postpartum visit). STUDY DESIGN: This retrospective cohort study selected 256 women delivered at Cooper University Hospital in Camden, NJ in 2013...
September 7, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Aaron Brice, Donna R Whelan, Naoto Ito, Kenta Shimizu, Linda Wiltzer-Bach, Camden Y Lo, Danielle Blondel, David A Jans, Toby D M Bell, Gregory W Moseley
Although microtubules (MTs) are known to have important roles in intracellular transport of many viruses, a number of reports suggest that specific viral MT-associated proteins (MAPs) target MTs to subvert distinct MT-dependent cellular processes. The precise functional importance of these interactions and their roles in pathogenesis, however, remain largely unresolved. To assess the association with disease of the rabies virus (RABV) MAP, P3, we quantitatively compared the phenotypes of P3 from a pathogenic RABV strain, Nishigahara (Ni) and a non-pathogenic Ni-derivative strain, Ni-CE...
2016: Scientific Reports
Sarah Griffin, Nicholas P Montoni, Guoliang Li, Patrick J Straney, Jill E Millstone, David J Masiello, Jon P Camden
Driven by the desire to understand energy transfer between plasmonic and catalytic metals for applications such as plasmon-mediated catalysis, we examine the spatially resolved electron energy-loss spectra (EELS) of both pure Au nanoprisms and Pt-decorated Au nanoprisms. The EEL spectra and the resulting surface-plasmon mode maps reveal detailed near-field information on the coupling and energy transfer in these systems, thereby elucidating the underlying mechanism of plasmon-driven chemical catalysis in mixed-metal nanostructures...
October 6, 2016: Journal of Physical Chemistry Letters
Camden Hebson, Wendy Book, Robert W Elder, Ryan Ford, Maan Jokhadar, Kirk Kanter, Brian Kogon, Adrienne H Kovacs, Rebecca D Levit, Michael Lloyd, Kevin Maher, Preeti Reshamwala, Fred Rodriguez, Rene Romero, Thor Tejada, Anne Marie Valente, Gruschen Veldtman, Michael McConnell
"Frontiers in Fontan Failure" was the title of a 2015 conference sponsored by Children's Healthcare of Atlanta and Emory University School of Medicine. In what is hoped to be the first of many such gatherings, speakers and attendees gathered to discuss the problem of long-term clinical deterioration in these patients. Specific focuses included properly defining the problem and then discussing different treatment strategies, both medical and surgical. The health of the liver after Fontan palliation was a particular point of emphasis, as were quality of life and future directions...
September 6, 2016: Congenital Heart Disease
Nomi Werbeloff, Maria Markou, Joseph F Hayes, Alexandra L Pitman, David P J Osborn
INTRODUCTION: Previous research has identified several risk factors that are strongly associated with suicidal behavior in patients with severe depression. However, the effects of area-level characteristics on suicidal ideation and attempt in this population remain unclear. METHODS: The Clinical Record Interactive Search (CRIS) database was used to identify 2587 patients with severe depression who received secondary mental health services from the Camden & Islington NHS Foundation Trust...
November 15, 2016: Journal of Affective Disorders
Karen Hurtubise, Lisa Rivard, Léa Héguy, Jade Berbari, Chantal Camden
INTRODUCTION: Knowledge transfer in pediatric rehabilitation is challenging and requires active, multifaceted strategies. The use of knowledge brokers (KBs) is one such strategy noted to promote clinician behavior change. The success of using KBs to transfer knowledge relies on their ability to adapt to ever-changing clinical contexts. In addition, with the rapid growth of online platforms as knowledge transfer forums, KBs must become effective in virtual environments. Although the role of KBs has been studied in various clinical contexts, their emerging role in specific online environments designed to support evidence-based behavior change has not yet been described...
2016: Journal of Continuing Education in the Health Professions
Damer P Blake, Martha Betson
The field of parasitism is broad, encompassing relationships between organisms where one benefits at the expense of another. Traditionally the discipline focuses on eukaryotes, with the study of bacteria and viruses complementary but distinct. Nonetheless, parasites vary in size and complexity from single celled protozoa, to enormous plants like those in the genus Rafflesia. Lifecycles range from obligate intracellular to extensive exoparasitism. Examples of parasites include high-profile medical and zoonotic pathogens such as Plasmodium, veterinary pathogens of wild and captive animals and many of the agents which cause neglected tropical diseases, stretching to parasites which infect plants and other parasites (e...
August 30, 2016: Parasitology
Chaoxiong Ma, Michael J Trujillo, Jon P Camden
Nanoporous metal films are promising substrates for surfaced-enhanced Raman scattering (SERS) measurement, owing to their homogeneity, large surface area, and abundant hot-spots. Herein, a facile procedure was developed to fabricate nanoporous Ag film on various substrate surfaces. Thermally deposited Ag film was first treated with O2 plasma, resulting in porous Ag/AgxO film (AgxO-NF) with nanoscale feature. Sodium citrate was then used to reduce AgxO to Ag, forming nanoporous Ag film (AgNF) with similar morphology...
September 14, 2016: ACS Applied Materials & Interfaces
Timothy Daniel Kayes, Gary A Weisman, Jean M Camden, Lucas T Woods, Cole Bredehoeft, Edward F Downey, James Cole, Helen Braley-Mullen
Sixty to seventy percent of IFN-γ(-/-) NOD.H-2h4 mice given sodium iodide (NaI)-supplemented water develop a slow onset autoimmune thyroid disease, characterized by thyrocyte epithelial cell (TEC) hyperplasia and proliferation (H/P). TEC H/P develops much earlier in CD28(-/-) mice and nearly 100% (both sexes) have severe TEC H/P at 4 mo of age. Without NaI supplementation, 50% of 5- to 6-mo-old CD28(-/-)IFN-γ(-/-) mice develop severe TEC H/P, and 2-3 wk of NaI is sufficient for optimal development of severe TEC H/P...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Camden J Hallmark, Mandy J Hill, Charles Luswata, Kellie L Watkins, Lupita Thornton, Marlene McNeese, Michael W Ross
BACKGROUND: After reaching an all-time low in 2000, syphilis incidence in the United States has increased as the burden shifted from heterosexuals to men who have sex with men (MSM). Houston, Texas, experienced 2 outbreaks of syphilis during this transformation in trends. Further evaluation is necessary to determine if these outbreaks occurred among the same subpopulations. METHODS: Surveillance data collected on all reported infectious syphilis cases in Houston from 1971 to 2013 were analyzed...
September 2016: Sexually Transmitted Diseases
Katherine P Gill, Sandy S C Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pébay, Raymond C B Wong
Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to vision impairment. Development of cell therapy requires a better understanding of the signals that direct stem cells into RGCs. Human embryonic stem cells (hESCs) represent an unlimited cellular source for generation of human RGCs in vitro. In this study, we present a 45-day protocol that utilises magnetic activated cell sorting to generate enriched population of RGCs via stepwise retinal differentiation using hESCs...
2016: Scientific Reports
Sarah L Snelgrove, Cecilia Lo, Pam Hall, Camden Y Lo, Maliha A Alikhan, P Toby Coates, Stephen R Holdsworth, Michael J Hickey, A Richard Kitching
BACKGROUND: The healthy kidney contains an extensive population of renal mononuclear phagocytes (RMPs), with substantial phenotypic and functional diversity. However, how this diverse population is affected by ischemia-reperfusion injury (IRI), an obligate part of renal transplantation, is not yet well understood. The aim of this study was to characterize the phenotypic and functional alterations in RMPs induced by IRI. METHODS: RMPs were studied 24 and 72 hours after 30 minutes of renal ischemia or sham operation...
August 5, 2016: Transplantation
Camden Yeung-Wah Lo, Sijie Chen, Sarah Jayne Creed, Miaomiao Kang, Na Zhao, Ben Zhong Tang, Kirstin Diana Elgass
Mitochondria and mitochondrial dynamics play vital roles in health and disease. With the intricate nanometer-scale structure and rapid dynamics of mitochondria, super-resolution microscopy techniques possess great un-tapped potential to significantly contribute to understanding mitochondrial biology and kinetics. Here we present a novel mitochondrial probe (MitoRed AIE) suitable for live mitochondrial dynamics imaging and single particle tracking (SPT), together with a multi-dimensional data analysis approach to assess local mitochondrial (membrane) fluidity...
2016: Scientific Reports
Stefan Priebe, Hana Pavlickova, Sandra Eldridge, Eoin Golden, Paul McCrone, Nick Ockenden, Nancy Pistrang, Michael King
INTRODUCTION: Social isolation is common in patients with psychosis and associated with a number of negative outcomes. Programmes in which volunteers provide one-to-one support-often referred to as befriending-have been reputed to achieve favourable outcomes. However, trial-based evidence for their effectiveness is limited. METHODS AND ANALYSIS: This is a randomised controlled trial comparing the effects of one-to-one volunteer support with an active control condition for patients with psychosis over a 1-year period...
2016: BMJ Open
Camden M Driggers, Kelsey M Kean, Lawrence L Hirschberger, Richard B Cooley, Martha H Stipanuk, P Andrew Karplus
In mammals, the non-heme iron enzyme cysteine dioxygenase (CDO) helps regulate Cys levels through converting Cys to Cys sulfinic acid. Its activity is in part modulated by the formation of a Cys93-Tyr157 crosslink that increases its catalytic efficiency over 10-fold. Here, 21 high-resolution mammalian CDO structures are used to gain insight into how the Cys-Tyr crosslink promotes activity and how select competitive inhibitors bind. Crystal structures of crosslink-deficient C93A and Y157F variants reveal similar ~1...
October 9, 2016: Journal of Molecular Biology
Elizabeth Holdsworth, Nicki Thorogood, Annik Sorhaindo, Kiran Nanchahal
Background Overweight and obesity are major public health problems and an increasing global challenge. In lieu of wider policy changes to tackle the obesogenic environment in which we presently reside, improving the design of individual-level weight loss interventions is important. Aim To identify which aspects of the Camden Weight Loss randomized controlled trial weight loss intervention participants engaged with, with the aim of improving the design of future studies and maximizing retention. Method A qualitative study comprising semistructured interviews (n = 18) and a focus group (n = 5) with intervention participants...
July 26, 2016: Health Promotion Practice
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