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https://www.readbyqxmd.com/read/29161521/lessons-from-the-camden-coalition-of-healthcare-providers-first-medicaid-shared-savings-performance-evaluation
#1
Aaron Truchil, Natasha Dravid, Stephen Singer, Zachary Martinez, Teagan Kuruna, Scott Waulters
Accountable Care Organizations (ACOs) aim to reduce health care costs while improving patient outcomes. Camden Coalition of Healthcare Providers' (Camden Coalition) work already aligned with this aim before receiving state approval to operate a certified Medicaid ACO in New Jersey. Upon its formation, the Camden Coalition ACO partnered with UnitedHealthcare and, through state legislation, Rutgers Center for State Health Policy (CSHP) was established as its external evaluator. In evaluating the Camden Coalition ACO, Rutgers CSHP built on the Medicare Shared Savings model, but modified it based on the understanding that the Medicaid population differs from the Medicare population...
November 21, 2017: Population Health Management
https://www.readbyqxmd.com/read/29161308/effects-of-tones-associated-with-drilling-activities-on-bowhead-whale-calling-rates
#2
Susanna B Blackwell, Christopher S Nations, Aaron M Thode, Mandy E Kauffman, Alexander S Conrad, Robert G Norman, Katherine H Kim
During summer 2012 Shell performed exploratory drilling at Sivulliq, a lease holding located in the autumn migration corridor of bowhead whales (Balaena mysticetus), northwest of Camden Bay in the Beaufort Sea. The drilling operation involved a number of vessels performing various activities, such as towing the drill rig, anchor handling, and drilling. Acoustic data were collected with six arrays of directional recorders (DASARs) deployed on the seafloor over ~7 weeks in Aug-Oct. Whale calls produced within 2 km of each DASAR were identified and localized using triangulation...
2017: PloS One
https://www.readbyqxmd.com/read/29128988/employing-community-voices-informing-practice-and-programming-through-camden-healthy-start-focus-groups
#3
Dianne R Browne, Sherolde Hackett, Allison Burger
Objectives Women living in communities with low-socioeconomic status, substandard healthcare, and ongoing exposure to social disparities encounter barriers to healthcare, often making it difficult to access health services. Barriers may stem from provider interactions with clients, conditions of the healthcare facility, or even language barriers. This prompts a call for providers to be keenly aware of the obstacles women encounter when attempting to access services. Methods In an effort to facilitate better access to services, Camden Healthy Start conducted six focus groups...
November 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29079602/randomised-controlled-trial-of-the-clinical-and-cost-effectiveness-of-a-peer-delivered-self-management-intervention-to-prevent-relapse-in-crisis-resolution-team-users-study-protocol
#4
Sonia Johnson, Oliver Mason, David Osborn, Alyssa Milton, Claire Henderson, Louise Marston, Gareth Ambler, Rachael Hunter, Stephen Pilling, Nicola Morant, Richard Gray, Tim Weaver, Fiona Nolan, Brynmor Lloyd-Evans
INTRODUCTION: Crisis resolution teams (CRTs) provide assessment and intensive home treatment in a crisis, aiming to offer an alternative for people who would otherwise require a psychiatric inpatient admission. They are available in most areas in England. Despite some evidence for their clinical and cost-effectiveness, recurrent concerns are expressed regarding discontinuity with other services and lack of focus on preventing future relapse and readmission to acute care. Currently evidence on how to prevent readmissions to acute care is limited...
October 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28989621/utilizing-light-triggered-plasmon-driven-catalysis-reactions-as-a-template-for-molecular-delivery-and-release
#5
Xin Gu, Huan Wang, Jon P Camden
Due to the facile manipulation and non-invasive nature of light-triggered release, it is one of the most potent ways to selectively and remotely deliver a molecular target. Among the various carrier platforms, plasmonic nanoparticles possess advantages such as enhanced cellular uptake and easy loading of "cargo" molecules. Two general strategies are currently utilized to achieve light-induced molecule release from plasmonic nanoparticles. The first uses femtosecond laser pulses to directly break the bond between the nanoparticle and the loaded target...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#6
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28887272/establishing-benchmarks-for-the-volume-outcome-relationship-for-common-lumbar-spine-surgical-procedures
#7
Andrew J Schoenfeld, Daniel J Sturgeon, Camden B Burns, Tyler J Hunt, Christopher M Bono
BACKGROUND CONTEXT: The importance of surgeon volume as a quality measure has been defined for a number of surgical specialties. Meaningful procedural volume benchmarks have not been established, however, particularly with respect to lumbar spine surgery. PURPOSE: We aimed to establish surgeon volume benchmarks for the performance of four common lumbar spine surgical procedures (discectomy, decompression, lumbar interbody fusion, and lumbar posterolateral fusion)...
September 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28886442/four-new-cases-of-pediatric-thoracic-aortic-aneurysm-taa-with-review-of-the-molecular-genetic-basis-utilizing-the-newly-published-consensus-nomenclature
#8
Shriprasad Deshpande, Adina Alazraki, Nasim Khoshnam, Diana Kantarovich, Pooya Hoseinzadeh, Camden Hebson, Ajay Bhatia, Lauren Schaffer, Elana Maccou, Bahig M Shehata
The majority of thoracic aortic aneurysms (TAA) in the pediatric population are due to post repair etiology (iatrogenic). Although rare, underlying inheritable disease and congenital cardiac anomalies represent the most common non-iatrogenic cause of TAA among patients in this age group (1-21 years of age). Herein, we present a case series of 9aortic aneurysms with varying underlying etiology. We discuss the molecular genetic basis of these syndromes in conjunction with the radiological findings and histological description utilizing the newly published consensus criteria article...
July 27, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28882279/benefit-cost-analysis-of-lane-departure-warning-and-roll-stability-control-in-commercial-vehicles
#9
Alejandra Medina-Flintsch, Jeffrey S Hickman, Feng Guo, Matthew C Camden, Richard J Hanowski, Quon Kwan
INTRODUCTION: This paper presents the cost benefits of two different onboard safety systems (OSS) installed on trucks as they operated during normal revenue deliveries. Using a formal economic analysis approach, the study quantified the costs and benefits associated with lane departure warning (LDW) systems and roll stability control (RSC) systems. METHODS: The study used data collected from participating carriers (many of these crashes were not reported to state or Federal agencies), and the research team also reviewed each crash file to determine if the specific OSS would have mitigated or prevented the crash...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28875062/interactions-between-energy-drink-consumption-and-sleep-problems-associations-with-alcohol-use-among-young-adolescents
#10
Naomi R Marmorstein
Background: Energy drink consumption and sleep problems are both associated with alcohol use among adolescents. In addition, caffeine consumption (including energy drinks) is associated with sleep problems. However, information about how these three constructs may interact is limited. The goal of this study was to examine potential interactions between energy drink consumption and sleep problems in the concurrent prediction of alcohol use among young adolescents. Coffee and soda consumption were also examined for comparison...
September 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28827277/an-investigation-of-the-predictors-of-photoprotection-and-uvr-dose-to-the-face-in-patients-with-xp-a-protocol-using-observational-mixed-methods
#11
Jessica Walburn, Robert Sarkany, Sam Norton, Lesley Foster, Myfanwy Morgan, Kirby Sainsbury, Vera Araújo-Soares, Rebecca Anderson, Isabel Garrood, Jakob Heydenreich, Falko F Sniehotta, Rute Vieira, Hans Christian Wulf, John Weinman
INTRODUCTION: Xeroderma pigmentosum (XP) is a rare genetic condition caused by defective nucleotide excision repair and characterised by skin cancer, ocular and neurological involvement. Stringent ultraviolet protection is the only way to prevent skin cancer. Despite the risks, some patients' photoprotection is poor, with a potentially devastating impact on their prognosis. The aim of this research is to identify disease-specific and psychosocial predictors of photoprotection behaviour and ultraviolet radiation (UVR) dose to the face...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28814388/impact-of-poxvirus-vector-priming-protein-coadministration-and-vaccine-intervals-on-hiv-gp120-vaccine-elicited-antibody-magnitude-and-function-in-infant-macaques
#12
Bonnie Phillips, Genevieve G Fouda, Josh Eudailey, Justin Pollara, Alan D Curtis, Erika Kunz, Maria Dennis, Xiaoying Shen, Camden Bay, Michael Hudgens, David Pickup, S Munir Alam, Amir Ardeshir, Pamela A Kozlowski, Koen K A Van Rompay, Guido Ferrari, M Anthony Moody, Sallie Permar, Kristina De Paris
Despite success in reducing vertical HIV transmission by maternal antiretroviral therapy, several obstacles limit its efficacy during breastfeeding, and breast-milk transmission is now the dominant mode of mother-to-child transmission (MTCT) of HIV in infants. Thus, a pediatric vaccine is needed to eradicate oral HIV infections in newborns and infants. Utilizing the infant rhesus macaque model, we compared 3 different vaccine regimens: (i) HIV envelope (Env) protein only, (ii) poxvirus vector (modified vaccinia virus Ankara [MVA])-HIV Env prime and HIV Env boost, and (iii) coadministration of HIV Env and MVA-HIV Env at all time points...
October 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28798231/p2x7-receptor-antagonism-prevents-il-1%C3%AE-release-from-salivary-epithelial-cells-and-reduces-inflammation-in-a-mouse-model-of-autoimmune-exocrinopathy
#13
Mahmoud G Khalafalla, Lucas T Woods, Jean M Camden, Aslam A Khan, Kirsten H Limesand, Michael J Petris, Laurie Erb, Gary A Weisman
Salivary gland inflammation is a hallmark of Sjögren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary gland and loss of saliva secretion, predominantly in women. The P2X7 receptor (P2X7R) is an ATP-gated nonselective cation channel that induces inflammatory responses in cells and tissues, including salivary gland epithelium. In immune cells, P2X7R activation induces the production of proinflammatory cytokines, including IL-1β and IL-18, by inducing the oligomerization of the multiprotein complex NLRP3-type inflammasome...
October 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28783685/homodimerization-attenuates-the-anti-inflammatory-activity-of-interleukin-37
#14
Andrew M Ellisdon, Claudia A Nold-Petry, Laura D'Andrea, Steven X Cho, Jason C Lao, Ina Rudloff, Devi Ngo, Camden Y Lo, Tatiana P Soares da Costa, Matthew A Perugini, Paul J Conroy, James C Whisstock, Marcel F Nold
Dysregulation of the inflammatory response underlies numerous diseases. Although most interleukin-1 family cytokines are proinflammatory, human interleukin-37 (IL-37) is a powerful, broad-spectrum inhibitor of inflammation and immunity. We determined the crystal structure of IL-37 to establish the anti-inflammatory mechanism of this key cytokine in view of developing IL-37-based therapies. We found that two β-trefoil fold IL-37 molecules form a head-to-head dimer that is stable in solution. IL-37 variants mutated to convert the cytokine into an obligate monomer were up to 13-fold more effective than the dimer in suppressing proinflammatory events both in primary human blood cells and in vivo in murine endotoxic shock...
February 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28782050/theranostic-gold-nanoantennas-for-simultaneous-multiplexed-raman-imaging-of-immunomarkers-and-photothermal-therapy
#15
Joseph A Webb, Yu-Chuan Ou, Shannon Faley, Eden P Paul, Joseph P Hittinger, Camden C Cutright, Eugene C Lin, Leon M Bellan, Rizia Bardhan
In this study, we demonstrate the theranostic capability of actively targeted, site-specific multibranched gold nanoantennas (MGNs) in triple-negative breast cancer (TNBC) cells in vitro. By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. A 1:1 mixture of MGNs functionalized with anti-PDL1 antibodies and Raman tag 5,5-dithio-bis-(2-nitrobenzoic acid) (DTNB) and MGNs functionalized with anti-EGFR antibodies and Raman tag para-mercaptobenzoic acid (pMBA) were incubated with the cells...
July 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28765539/bacterial-membrane-vesicles-transport-their-dna-cargo-into-host-cells
#16
Natalie J Bitto, Ross Chapman, Sacha Pidot, Adam Costin, Camden Lo, Jasmine Choi, Tanya D'Cruze, Eric C Reynolds, Stuart G Dashper, Lynne Turnbull, Cynthia B Whitchurch, Timothy P Stinear, Katryn J Stacey, Richard L Ferrero
Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins. OMVs are reported to contain DNA, however, little is known about the nature of this DNA, nor whether it can be transported into host cells. Our work demonstrates that chromosomal DNA is packaged into OMVs shed by bacteria during exponential phase. Most of this DNA was present on the external surfaces of OMVs, with smaller amounts located internally. The DNA within the internal compartments of Pseudomonas aeruginosa OMVs were consistently enriched in specific regions of the bacterial chromosome, encoding proteins involved in virulence, stress response, antibiotic resistance and metabolism...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757228/cluster-analysis-of-acute-care-use-yields-insights-for-tailored-pediatric-asthma-interventions
#17
Mahshid Abir, Aaron Truchil, Dawn Wiest, Daniel B Nelson, Jason E Goldstick, Paul Koegel, Marie M Lozon, Hwajung Choi, Jeffrey Brenner
STUDY OBJECTIVE: We undertake this study to understand patterns of pediatric asthma-related acute care use to inform interventions aimed at reducing potentially avoidable hospitalizations. METHODS: Hospital claims data from 3 Camden city facilities for 2010 to 2014 were used to perform cluster analysis classifying patients aged 0 to 17 years according to their asthma-related hospital use. Clusters were based on 2 variables: asthma-related ED visits and hospitalizations...
July 27, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28714097/a-randomized-comparative-pilot-trial-of-family-based-interpersonal-psychotherapy-for-reducing-psychosocial-symptoms-disordered-eating-and-excess-weight-gain-in-at-risk-preadolescents-with-loss-of-control-eating
#18
Lauren B Shomaker, Marian Tanofsky-Kraff, Camden E Matherne, Rim D Mehari, Cara H Olsen, Shannon E Marwitz, Jennifer L Bakalar, Lisa M Ranzenhofer, Nichole R Kelly, Natasha A Schvey, Natasha L Burke, Omni Cassidy, Sheila M Brady, Laura J Dietz, Denise E Wilfley, Susan Z Yanovski, Jack A Yanovski
OBJECTIVE: Preadolescent loss-of-control-eating (LOC-eating) is a risk factor for excess weight gain and binge-eating-disorder. We evaluated feasibility and acceptability of a preventive family-based interpersonal psychotherapy (FB-IPT) program. FB-IPT was compared to family-based health education (FB-HE) to evaluate changes in children's psychosocial functioning, LOC-eating, and body mass. METHOD: A randomized, controlled pilot trial was conducted with 29 children, 8 to 13 years who had overweight/obesity and LOC-eating...
July 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28700461/student-hotspotting-teaching-the-interprofessional-care-of-complex-patients
#19
Pablo Bedoya, Katherine Neuhausen, Alan Dow, E Marshall Brooks, Dawn Mautner, Rebecca S Etz
PROBLEM: Individuals with complex health and social needs drive much of the total cost of care. Addressing these individuals' needs and decreasing costs requires interprofessional teams, called "hotspotters," who engage with communities with high utilization. Training health professions students to succeed in the hotspotting approach may benefit trainees, academic health centers (AHCs), and communities. APPROACH: The Camden Coalition of Healthcare Providers and the Association of American Medical Colleges launched the Interprofessional Student Hotspotting Learning Collaborative in 2014...
July 11, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28690691/impact-of-a-pharmacy-technician-centered-medication-reconciliation-program-on-medication-discrepancies-and-implementation-of-recommendations
#20
Sarah K Kraus, Sanchita Sen, Michelle Murphy, Laura Pontiggia
OBJECTIVES: To evaluate the impact of a pharmacy-technician centered medication reconciliation (PTMR) program by identifying and quantifying medication discrepancies and outcomes of pharmacist medication reconciliation recommendations. METHODS: A retrospective chart review was performed on two-hundred patients admitted to the internal medicine teaching services at Cooper University Hospital in Camden, NJ. Patients were selected using a stratified systematic sample approach and were included if they received a pharmacy technician medication history and a pharmacist medication reconciliation at any point during their hospital admission...
April 2017: Pharmacy Practice
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