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https://www.readbyqxmd.com/read/28798231/p2x7-receptor-antagonism-prevents-il-1%C3%AE-release-from-salivary-epithelial-cells-and-reduces-inflammation-in-a-mouse-model-of-autoimmune-exocrinopathy
#1
Mahmoud G Khalafalla, Lucas T Woods, Jean M Camden, Aslam A Khan, Kirsten H Limesand, Michael J Petris, Laurie Erb, Gary A Weisman
Salivary gland inflammation is a hallmark of Sjogrens syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary gland and loss of saliva secretion, predominantly in women. The P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel that induces inflammatory responses in cells and tissues, including salivary gland epithelium. In immune cells, P2X7R activation induces the production of proinflammatory cytokines, including IL-1β and IL-18, by inducing the oligomerization of the multiprotein complex NLRP3-type inflammasome...
August 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28783685/homodimerization-attenuates-the-anti-inflammatory-activity-of-interleukin-37
#2
Andrew M Ellisdon, Claudia A Nold-Petry, Laura D'Andrea, Steven X Cho, Jason C Lao, Ina Rudloff, Devi Ngo, Camden Y Lo, Tatiana P Soares da Costa, Matthew A Perugini, Paul J Conroy, James C Whisstock, Marcel F Nold
Dysregulation of the inflammatory response underlies numerous diseases. Although most interleukin-1 family cytokines are proinflammatory, human interleukin-37 (IL-37) is a powerful, broad-spectrum inhibitor of inflammation and immunity. We determined the crystal structure of IL-37 to establish the anti-inflammatory mechanism of this key cytokine in view of developing IL-37-based therapies. We found that two β-trefoil fold IL-37 molecules form a head-to-head dimer that is stable in solution. IL-37 variants mutated to convert the cytokine into an obligate monomer were up to 13-fold more effective than the dimer in suppressing proinflammatory events both in primary human blood cells and in vivo in murine endotoxic shock...
February 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28782050/theranostic-gold-nanoantennas-for-simultaneous-multiplexed-raman-imaging-of-immunomarkers-and-photothermal-therapy
#3
Joseph A Webb, Yu-Chuan Ou, Shannon Faley, Eden P Paul, Joseph P Hittinger, Camden C Cutright, Eugene C Lin, Leon M Bellan, Rizia Bardhan
In this study, we demonstrate the theranostic capability of actively targeted, site-specific multibranched gold nanoantennas (MGNs) in triple-negative breast cancer (TNBC) cells in vitro. By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. A 1:1 mixture of MGNs functionalized with anti-PDL1 antibodies and Raman tag 5,5-dithio-bis-(2-nitrobenzoic acid) (DTNB) and MGNs functionalized with anti-EGFR antibodies and Raman tag para-mercaptobenzoic acid (pMBA) were incubated with the cells...
July 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28765539/bacterial-membrane-vesicles-transport-their-dna-cargo-into-host-cells
#4
Natalie J Bitto, Ross Chapman, Sacha Pidot, Adam Costin, Camden Lo, Jasmine Choi, Tanya D'Cruze, Eric C Reynolds, Stuart G Dashper, Lynne Turnbull, Cynthia B Whitchurch, Timothy P Stinear, Katryn J Stacey, Richard L Ferrero
Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins. OMVs are reported to contain DNA, however, little is known about the nature of this DNA, nor whether it can be transported into host cells. Our work demonstrates that chromosomal DNA is packaged into OMVs shed by bacteria during exponential phase. Most of this DNA was present on the external surfaces of OMVs, with smaller amounts located internally. The DNA within the internal compartments of Pseudomonas aeruginosa OMVs were consistently enriched in specific regions of the bacterial chromosome, encoding proteins involved in virulence, stress response, antibiotic resistance and metabolism...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757228/cluster-analysis-of-acute-care-use-yields-insights-for-tailored-pediatric-asthma-interventions
#5
Mahshid Abir, Aaron Truchil, Dawn Wiest, Daniel B Nelson, Jason E Goldstick, Paul Koegel, Marie M Lozon, Hwajung Choi, Jeffrey Brenner
STUDY OBJECTIVE: We undertake this study to understand patterns of pediatric asthma-related acute care use to inform interventions aimed at reducing potentially avoidable hospitalizations. METHODS: Hospital claims data from 3 Camden city facilities for 2010 to 2014 were used to perform cluster analysis classifying patients aged 0 to 17 years according to their asthma-related hospital use. Clusters were based on 2 variables: asthma-related ED visits and hospitalizations...
July 27, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28714097/a-randomized-comparative-pilot-trial-of-family-based-interpersonal-psychotherapy-for-reducing-psychosocial-symptoms-disordered-eating-and-excess-weight-gain-in-at-risk-preadolescents-with-loss-of-control-eating
#6
Lauren B Shomaker, Marian Tanofsky-Kraff, Camden E Matherne, Rim D Mehari, Cara H Olsen, Shannon E Marwitz, Jennifer L Bakalar, Lisa M Ranzenhofer, Nichole R Kelly, Natasha A Schvey, Natasha L Burke, Omni Cassidy, Sheila M Brady, Laura J Dietz, Denise E Wilfley, Susan Z Yanovski, Jack A Yanovski
OBJECTIVE: Preadolescent loss-of-control-eating (LOC-eating) is a risk factor for excess weight gain and binge-eating-disorder. We evaluated feasibility and acceptability of a preventive family-based interpersonal psychotherapy (FB-IPT) program. FB-IPT was compared to family-based health education (FB-HE) to evaluate changes in children's psychosocial functioning, LOC-eating, and body mass. METHOD: A randomized, controlled pilot trial was conducted with 29 children, 8 to 13 years who had overweight/obesity and LOC-eating...
July 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28700461/student-hotspotting-teaching-the-interprofessional-care-of-complex-patients
#7
Pablo Bedoya, Katherine Neuhausen, Alan Dow, E Marshall Brooks, Dawn Mautner, Rebecca S Etz
PROBLEM: Individuals with complex health and social needs drive much of the total cost of care. Addressing these individuals' needs and decreasing costs requires interprofessional teams, called "hotspotters," who engage with communities with high utilization. Training health professions students to succeed in the hotspotting approach may benefit trainees, academic health centers (AHCs), and communities. APPROACH: The Camden Coalition of Healthcare Providers and the Association of American Medical Colleges launched the Interprofessional Student Hotspotting Learning Collaborative in 2014...
July 11, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28690691/impact-of-a-pharmacy-technician-centered-medication-reconciliation-program-on-medication-discrepancies-and-implementation-of-recommendations
#8
Sarah K Kraus, Sanchita Sen, Michelle Murphy, Laura Pontiggia
OBJECTIVES: To evaluate the impact of a pharmacy-technician centered medication reconciliation (PTMR) program by identifying and quantifying medication discrepancies and outcomes of pharmacist medication reconciliation recommendations. METHODS: A retrospective chart review was performed on two-hundred patients admitted to the internal medicine teaching services at Cooper University Hospital in Camden, NJ. Patients were selected using a stratified systematic sample approach and were included if they received a pharmacy technician medication history and a pharmacist medication reconciliation at any point during their hospital admission...
April 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28592241/effect-of-major-school-playground-reconstruction-on-physical-activity-and-sedentary-behaviour-camden-active-spaces
#9
Mark Hamer, Daniel Aggio, Georgina Knock, Courtney Kipps, Aparna Shankar, Lee Smith
BACKGROUND: The physical school environment is a promising setting to increase children's physical activity although robust evidence is sparse. We examined the effects of major playground reconstruction on physical activity and sedentary time in primary schools using a quasi-experimental design (comparison group pre-test/post-test design). METHODS: Five experimental and two control schools from deprived areas of inner city London were recruited at baseline. Main outcome was physical activity and sedentary time measured from objective monitoring (Actigraph accelerometer) at one year follow up...
June 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28584128/bcl11b-and-combinatorial-resolution-of-cell-fate-in-the-t-cell-gene-regulatory-network
#10
William J R Longabaugh, Weihua Zeng, Jingli A Zhang, Hiroyuki Hosokawa, Camden S Jansen, Long Li, Maile Romero-Wolf, Pentao Liu, Hao Yuan Kueh, Ali Mortazavi, Ellen V Rothenberg
T-cell development from hematopoietic progenitors depends on multiple transcription factors, mobilized and modulated by intrathymic Notch signaling. Key aspects of T-cell specification network architecture have been illuminated through recent reports defining roles of transcription factors PU.1, GATA-3, and E2A, their interactions with Notch signaling, and roles of Runx1, TCF-1, and Hes1, providing bases for a comprehensively updated model of the T-cell specification gene regulatory network presented herein...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28495478/determinants-of-sugar-sweetened-beverage-consumption-among-low-income-children-are%C3%A2-there-differences-by-race-ethnicity-age-and-sex
#11
Natasha Tasevska, Derek DeLia, Cori Lorts, Michael Yedidia, Punam Ohri-Vachaspati
BACKGROUND: Understanding determinants of high consumption of sugar-sweetened beverages (SSBs), a highly prevalent obesogenic behavior, will help build effective customized public health interventions. OBJECTIVE: Our aim was to identify child and parent lifestyle and household demographic factors predictive of high SSB consumption frequency in children from low-income, ethnically diverse communities that may help inform public health interventions. DESIGN: We used a cross-sectional telephone household survey...
May 8, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28444245/can-a-community-of-practice-improve-physical-therapists-self-perceived-practice-in-developmental-coordination-disorder
#12
Chantal Camden, Lisa M Rivard, Karen Hurtubise, Léa Héguy, Jade Berbari
Background: Communities of practice (CoP ) are useful knowledge translation (KT) strategies but little is known about their impact on physical therapists' (PTs) self-perceived practice. Purpose: We evaluated the impact of a CoP on PTs' self-perceived practice, and explored factors influencing changes in self-perceived knowledge, skills, and practice related to developmental coordination disorder (DCD). Design: We used an explanatory sequential mixed-methods design, guided by The Theory of Reasoned Action and Theory of Planned Behavior...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28397914/improving-target-amino-acid-selectivity-in-a-permissive-aminoacyl-trna-synthetase-through-counter-selection
#13
Itthipol Sungwienwong, Zachary M Hostetler, Robert J Blizzard, Joseph J Porter, Camden M Driggers, Lea Z Mbengi, José A Villegas, Lee C Speight, Jeffery G Saven, John J Perona, Rahul M Kohli, Ryan A Mehl, E James Petersson
The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein dynamics, either alone or as part of a Förster resonance energy transfer (FRET) or photo-induced electron transfer (eT) probe pair. We have previously reported the genetic incorporation of Acd by an aminoacyl tRNA synthetase (RS). However, this RS, developed from a library of permissive RSs, also incorporates N-phenyl-aminophenylalanine (Npf), a trace byproduct of one Acd synthetic route. We have performed negative selections in the presence of Npf and analyzed the selectivity of the resulting AcdRSs by in vivo protein expression and detailed kinetic analyses of the purified RSs...
May 3, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28385409/coincidental-significant-tricuspid%C3%A2-regurgitation-at-the-time-of%C3%A2-right-ventricle-to-pulmonary-artery-conduit%C3%A2-intervention-should-we-address-it-ignore-it-or-take-a-more-nuanced-approach
#14
EDITORIAL
Camden L Hebson, Georges Ephrem, Fred H Rodriguez
No abstract text is available yet for this article.
April 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28383922/surface-enhanced-resonance-hyper-raman-scattering-elucidates-the-molecular-orientation-of-rhodamine-6g-on-silver-colloids
#15
Hubert K Turley, Zhongwei Hu, Lasse Jensen, Jon P Camden
Herein, we utilize surface-enhanced hyper-Raman scattering (SEHRS) under resonance conditions to probe the adsorbate geometry of rhodamine 6G (R6G) on silver colloids. Our results show resonance SEHRS is highly sensitive to molecular orientation due to non-Condon effects, which do not appear in its linear counterpart surface-enhanced Raman scattering. Comparisons between simulated and measured SEHRS spectra reveal R6G adsorbs mostly perpendicular to the nanoparticle surface along the ethylamine groups with the xanthene ring oriented edgewise...
April 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28374826/ovine-multiparity-is-associated-with-diminished-vaginal-muscularis-increased-elastic-fibres-and-vaginal-wall-weakness-implication-for-pelvic-organ-prolapse
#16
Stuart Emmerson, Natharnia Young, Anna Rosamilia, Luke Parkinson, Sharon L Edwards, Aditya V Vashi, Miranda Davies-Tuck, Jacinta White, Kirstin Elgass, Camden Lo, John Arkwright, Jerome A Werkmeister, Caroline E Gargett
Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised that increasing parity weakens the vagina by altering the extracellular matrix proteins and smooth muscle thereby leading to POP vulnerability. We used a modified POP-quantification (POP-Q) system and a novel pressure sensor to measure vaginal wall weakness in nulliparous, primiparous and multiparous ewes. These measurements were correlated with histological, biochemical and biomechanical properties of the ovine vagina...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28338419/competitive-protein-binding-influences-heparin-based-modulation-of-spatial-growth-factor-delivery-for-bone-regeneration
#17
Marian H Hettiaratchi, Catherine Chou, Nicholas Servies, Johanna M Smeekens, Albert Cheng, Camden Esancy, Ronghu Wu, Todd C McDevitt, Robert E Guldberg, Laxminarayanan Krishnan
Tissue engineering strategies involving the in vivo delivery of recombinant growth factors are often limited by the inability of biomaterials to spatially control diffusion of the delivered protein within the site of interest. The poor spatiotemporal control provided by porous collagen sponges, which are used for the clinical delivery of bone morphogenetic protein-2 (BMP-2) for bone regeneration, has necessitated the use of supraphysiological protein doses, leading to inflammation and heterotopic ossification...
July 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28323061/influence-of-product-placement-in-children-s-movies-on-children-s-snack-choices
#18
Callie L Brown, Camden E Matherne, Cynthia M Bulik, Janna B Howard, Sophie N Ravanbakht, Asheley C Skinner, Charles T Wood, Anna M Bardone-Cone, Jane D Brown, Andrew J Perrin, Cary Levine, Michael J Steiner, Eliana M Perrin
BACKGROUND: Media exposure affects health, including obesity risk. Children's movies often contain food placements-frequently unhealthy foods. However, it is not known if these cues influence children's food choices or consumption after viewing. We explored whether children's snack choices or consumption differs based on: 1) recent exposure to movies with high versus low product placement of unhealthy foods; and 2) children's weight status. METHODS: Children ages 9-11 were assigned to watch a high ("Alvin and the Chipmunks," n = 54) or low ("Stuart Little," n = 60) product-placement movie...
July 1, 2017: Appetite
https://www.readbyqxmd.com/read/28277411/testing-for-urinary-tract-infection-in-the-influenza-respiratory-syncytial-virus-positive-febrile-infant-aged-2-to-12-months
#19
Anna Kathleen Schlechter Salinas, David S Hains, Tamekia Jones, Camden Harrell, Mark Meredith
OBJECTIVE: Infants 12 months or younger with influenza and respiratory syncytial virus (RSV) commonly present to the emergency department (ED) with fever. Previous publications have recommended that these patients have a urinalysis and urine culture performed. We aimed to assess the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the ED. We also examined whether the 2011 American Academy of Pediatrics (AAP) UTI clinical practice guidelines could be used to identify patients at lower risk of UTI...
March 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28259698/glycemia-but-not-the-metabolic-syndrome-is-associated-with-cognitive-decline-findings-from-the-european-male-ageing-study
#20
Margot J Overman, Neil Pendleton, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Gianni Forti, Giulia Rastrelli, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, David M Lee, Elon S Correa, Tomas Ahern, Michaël R Laurent, Sabine M P Verschueren, Leen Antonio, Evelien Gielen, Martin K Rutter, Dirk Vanderschueren, Frederick C W Wu, Jos Tournoy
OBJECTIVE: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. METHODS: Over a mean of 4.4 years (SD ± 0...
June 2017: American Journal of Geriatric Psychiatry
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