keyword
https://read.qxmd.com/read/38496823/clinical-validation-of-the-proenkephalin-penk-methylation-urine-test-for-monitoring-recurrence-of-non-muscle-invasive-bladder-cancer
#21
JOURNAL ARTICLE
Hyunho Han, Tae Jeong Oh, Ji Eun Heo, Jongsoo Lee, Won Sik Jang, Seung Hwan Lee, Won Sik Ham, Jaehee Hwang, Sungwhan An, Young-Deuk Choi
BACKGROUND AND OBJECTIVE: To assess the effectiveness of a urine-based proenkephalin ( PENK) methylation test using linear target enrichment-quantitative methylation-specific polymerase chain reaction (me PENK test) for detection of non-muscle-invasive bladder cancer (NMIBC) recurrence compared to cytology and the NMP22 test. METHODS: We first conducted a retrospective case-control study involving 54 patients with primary BC and 29 healthy individuals. We then prospectively enrolled 186 patients (January to December 2022) undergoing cystoscopy surveillance after transurethral resection of bladder tumor, of whom 59 had recurrent tumors...
April 2024: European urology open science
https://read.qxmd.com/read/38496809/orodental-injury-and-mouthguard-usage-in-dutch-and-international-field-hockey
#22
JOURNAL ARTICLE
Kirsten E van Vliet, Jan de Lange, Henk S Brand, Frank Lobbezoo
BACKGROUND: Mouthguards are used to prevent players from orodental injuries in field hockey. However, such injuries are still a common problem. This study describes the prevalence of orodental injury and the related mouthguard usage in field hockey. MATERIAL AND METHODS: A 19-item questionnaire was distributed in the Dutch field hockey competition and at the international Master World Cup. In total, 1213 questionnaires were collected. Standard descriptive statistics were used to describe the samples...
February 2024: Journal of Clinical and Experimental Dentistry
https://read.qxmd.com/read/38496711/exploring-pregnant-individuals-counseling-needs-regarding-urgent-imaging-to-rule-out-pulmonary-embolism
#23
JOURNAL ARTICLE
Suzie Ouellet, Sandrine Hamel, Camille Simard, Maral Koolian, Antony Robert, Karen Wou, Stéphanie Lam, Amal Bessissow, Sarah St-Georges, Vicky Tagalakis, Alexandra de Pokomandy, Linda Snell, Ning-Zi Sun, Isabelle Malhamé
BACKGROUND: Computed tomography pulmonary angiogram and lung scintigraphy with ventilation/perfusion scan are needed to diagnose pulmonary embolism (PE) in pregnancy. Their associated ionizing radiation doses are considered safe in pregnancy. A standardized patient information tool may improve patient counseling and reduce testing hesitancy. OBJECTIVES: In this context, we sought to address 1) what patients want to know before undergoing these tests and 2) how they want the information to be provided to them...
February 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38496530/unifying-approaches-from-statistical-genetics-and-phylogenetics-for-mapping-phenotypes-in-structured-populations
#24
Joshua G Schraiber, Michael D Edge, Matt Pennell
In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these two fields, there are sophisticated but disparate statistical traditions aimed at these tasks. The disconnect between their respective approaches is becoming untenable as questions in medicine, conservation biology, and evolutionary biology increasingly rely on integrating data from within and among species, and once-clear conceptual divisions are becoming increasingly blurred...
March 7, 2024: bioRxiv
https://read.qxmd.com/read/38496389/the-importance-of-rapid-assessment-tools-in-evaluating-mental-health-in-emergency-departments-among-patients-with-chronic-diseases
#25
JOURNAL ARTICLE
Aditya Lal Vallath, Barath Prashanth Sivasubramanian, Diviya Bharathi Ravikumar, Akshita Lalendran, Suhasini Krishnan, Sudeshna Samanta, Snigda Banerjee, Tania Das, Ritwick Kundu, Vyom Richharia, Ravisha More, Mishika Khithani, Sahana Nazimudeen, Sasidhar Gunturu, Indraneel Dasgupta
BACKGROUND: Rapid screening tools such as the WHO well-being Index (WWBI), Six-item screener (SIS), and the CLOX-1 test can be used to assess overall mental health and cognition, respectively. We sought to evaluate mental health with cognition in individuals with chronic diseases and stable vital signs presenting to the Emergency Department (ED). METHODS: An observational study in the ED with 279 participants was conducted. RESULTS: Chronic diseases were more prevalent among 51-70 years (43...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38496304/preexisting-antibody-assays-for-gene-therapy-considerations-on-patient-selection-cutoffs-and-companion-diagnostic-requirements
#26
REVIEW
Manuela Braun, Claudia Lange, Philipp Schatz, Brian Long, Johannes Stanta, Boris Gorovits, Edit Tarcsa, Vibha Jawa, Tong-Yuan Yang, Wibke Lembke, Nicole Miller, Fraser McBlane, Louis Christodoulou, Daisy Yuill, Mark Milton
Recombinant adeno-associated virus (AAV) vectors are the leading delivery vehicle used for in vivo gene therapies. Anti-AAV antibodies (AAV Abs) can interact with the viral capsid component of an AAV-based gene therapy (GT). Therefore, patients with preexisting AAV Abs (seropositive patients) are often excluded from GT trials to prevent treatment of patients who are unlikely to benefit1 or may have a higher risk for adverse events outweighing treatment benefits. On the contrary, unnecessary exclusion of patients with high unmet medical need should be avoided...
March 14, 2024: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38496282/development-of-korean-representative-headforms-for-the-total-inward-leakage-testing-on-filtering-facepiece-respirators
#27
JOURNAL ARTICLE
Ah Lam Lee, Xin Cui, Hayoung Jung, Hee Eun Kim, Eun Jin Jeon, Hyungjin Na, Eunmi Kim, Heecheon You
BACKGROUND: The lack of headforms that accurately reflect the head characteristics of Koreans and the demographic composition of the Korean population can lead to inadequate FFR testing and reduced effectiveness of FFRs. METHOD: Direct measurements of 5,110 individuals and 3D measurements of 2,044 individuals, aged between 9 and 69 years, were sampled from the data pool of Size Korea surveys based on the age and gender ratios of the Korean resident demographics...
March 2024: Safety and Health At Work
https://read.qxmd.com/read/38496219/virtual-reality-supported-intervention-program-for-trauma-symptoms-of-individuals-who-experienced-an-earthquake-an-effectiveness-study
#28
JOURNAL ARTICLE
Ali Yasin Kafes, Alpay Çiller, Mehmet Şakiroğlu
INTRODUCTION: This study aimed to develop an effective virtual reality (VR)-based intervention program to improve trauma symptoms of survivors of the 2023 Kahramanmaraş earthquake. METHODS: In line with this aim, the sample of the study consisted of 34 earthquake survivors aged 15-72 years (mean: 38.09, standard deviation (SD): 15.09) who were directly affected by the Kahramanmaraş earthquake on February 6, 2023. A five-stage intervention program (normalization, reinterpretation, creating a safe place, developing problem-focused coping strategies, and social support) was applied to 17 participants (mean: 36...
2024: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/38496188/experiment-to-demonstrate-pesticide-induced-antimicrobial-resistance-amr-an-emerging-health-threat
#29
JOURNAL ARTICLE
Rahil Pasha S A, Namitha B N, Warisha Ismail, Repati Gowri, Arvind Natarajan
Background Pesticides, including insecticides, herbicides, and fungicides, are essential for global food production, boosting crop yields, and preventing disease transmission. However, their excessive and improper use raises concerns about potential long-term consequences, affecting microbial ecosystems and fostering antimicrobial resistance. Materials and methods The objective of the study was to identify the effect of the pesticide compound (Imidacloprid 17.1% w/w) on the ATCC  Escherichia coli ...
February 2024: Curēus
https://read.qxmd.com/read/38496123/study-on-vitamin-d-levels-in-30-to-40-year-old-females-with-low-back-pain
#30
JOURNAL ARTICLE
Nimisha V, Gautham G Nair, Biju C Jose, Angel Abraham
BACKGROUND: Vitamin D is associated with many skeletal-related processes in the body. A major health problem concerning decreased quality of life is chronic low back pain (LBP). Many studies have proved that chronic pain improves with Vitamin D supplementation. This study aimed to explore the correlation between vitamin D levels and the occurrence of LBP in women aged 30 to 40. MATERIALS AND METHODS: A case-control study was taken up at PK Das Institute of Medical Sciences wherein 50 cases (women aged 30-34 years who had chronic LBP >3 months) and 50 age-matched controls were included...
February 2024: Curēus
https://read.qxmd.com/read/38496027/role-of-the-score-for-the-targeting-of-atrial-fibrillation-staf-combined-with-d-dimer-in-screening-ischemic-stroke-patients-with-atrial-fibrillation
#31
JOURNAL ARTICLE
Libin Liu, Peikai Xie, Peipei Zhu, Wenyan Zhuo, Anding Xu
BACKGROUND: We aim to explore the effect of the score for the targeting of atrial fibrillation (STAF) combined with the serum D-dimer (DD) level in screening acute ischemic stroke patients with atrial fibrillation (AF). METHODS: This study is a retrospective case observation study. This study consecutively selected patients with acute ischemic stroke who were hospitalized in the Department of Neurology at Zhuhai Hospital Affiliated with Jinan University from February 2019 to February 2021...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38495972/the-role-of-probiotics-in-the-eradication-of-helicobacter-pylori-and-overall-impact-on-management-of-peptic-ulcer-a-study-involving-patients-undergoing-triple-therapy-in-bangladesh
#32
JOURNAL ARTICLE
Taslima Zaman, Ahsanul Haq, Rahnuma Ahmad, Susmita Sinha, Kona Chowdhury, Sultana Parvin, Mostofa Imran, Zaman U Humayra, Santosh Kumar, Mainul Haque
Background Helicobacter pylori infection has been identified to cause constantly recurring inflammation, leading to gastrointestinal tract disorders, including carcinoma. The standard triple therapy (STT), used to eradicate H. pylori, includes two antimicrobials and a proton pump inhibitor for two weeks. Other drug regimens have also been developed since H. pylori exhibits antimicrobial resistance. These regimens, including probiotics, have been shown to lower adverse drug reactions (ADR), improve drug adherence, exert bacteriostatic effect, and reduce inflammation...
March 2024: Curēus
https://read.qxmd.com/read/38495863/machine-learning-methods-to-discriminate-posttraumatic-stress-disorder-a-protocol-of-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Jing Wang, Hui Ouyang, Runda Jiao, Haiyan Zhang, Suhui Cheng, Zhilei Shang, Yanpu Jia, Wenjie Yan, Lili Wu, Weizhi Liu
INTRODUCTION: Recent years have witnessed a persistent threat to public mental health, especially during and after the COVID-19 pandemic. Posttraumatic stress disorder (PTSD) has emerged as a pivotal concern amidst this backdrop. Concurrently, machine learning (ML) techniques have progressively applied in the realm of mental health. Therefore, our present undertaking seeks to provide a comprehensive assessment of studies employing ML methods that use diverse data modalities on the classification of people with PTSD...
2024: Digital Health
https://read.qxmd.com/read/38495835/prognostic-biomarker-hif1%C3%AE-and-its-correlation-with-immune-infiltration-in-gliomas
#34
JOURNAL ARTICLE
Zihan Ding, Jiaming Zhang, Lin Li, Chunliang Wang, Jinhong Mei
Certain glioma subtypes, such as glioblastoma multiforme or low-grade glioma, are common malignant intracranial tumors with high rates of relapse and malignant progression even after standard therapy. The overall survival (OS) is poor in patients with gliomas; hence, effective prognostic prediction is crucial. Herein, the present study aimed to explore the potential role of hypoxia-inducible factor 1 subunit alpha (HIF1α) in gliomas and investigate the association between HIF1α and infiltrating immune cells in gliomas...
May 2024: Oncology Letters
https://read.qxmd.com/read/38495828/assessment-of-search-strategies-in-medline-to-identify-studies-on-the-impact-of-long-covid-on-workability
#35
JOURNAL ARTICLE
Jean-François Gehanno, Isabelle Thaon, Carole Pelissier, Laetitia Rollin
OBJECTIVES: Studies on the impact of long COVID on work capacity are increasing but are difficult to locate in bibliographic databases, due to the heterogeneity of the terms used to describe this new condition and its consequences. This study aims to report on the effectiveness of different search strategies to find studies on the impact of long COVID on work participation in PubMed and to create validated search strings. METHODS: We searched PubMed for articles published on Long COVID and including information about work...
2024: Frontiers in Research Metrics and Analytics
https://read.qxmd.com/read/38495795/locally-advanced-oral-squamous-cell-carcinomas-auditing-and-outcome-appraisal
#36
JOURNAL ARTICLE
Rathindra Nath Bera, Richik Tripathi, Sapna Tandon, Mohd Adil, Sanober Sohail, Shashank, Avishek Chakraborty
UNLABELLED: Introduction: Patients with OSCC in India (oral squamous cell carcinoma) presents at a later stage with approximately 28% presenting at stage III and 64% at stage IV disease. In this retrospective study we have reviewed the treatment modalities rendered and outcomes associated for the management of locally advanced oral squamous cell carcinoma in our Institute. We evaluated the survival data and the factors effecting survival. Methods: Kaplan Meir method was used to evaluate OS and DFS rate and log rank test was used to compare the survival amongst groups...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38495670/metabolic-syndrome-traits-exhibit-genotype-by-environment-interaction-in-relation-to-socioeconomic-status-in-the-mexican-american-family-heart-study
#37
JOURNAL ARTICLE
Vincent P Diego, Eron G Manusov, Xi Mao, Marcio Almeida, Juan M Peralta, Joanne E Curran, Michael C Mahaney, Harald Göring, John Blangero, Sarah Williams-Blangero
Background: Socioeconomic Status (SES) is a potent environmental determinant of health. To our knowledge, no assessment of genotype-environment interaction has been conducted to consider the joint effects of socioeconomic status and genetics on risk for metabolic disease. We analyzed data from the Mexican American Family Studies (MAFS) to evaluate the hypothesis that genotype-by-environment interaction (GxE) is an essential determinant of variation in risk factors for metabolic syndrome (MS). Methods: We employed a maximum likelihood estimation of the decomposition of variance components to detect GxE interaction...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38495516/macrolide-resistance-in-mannheimia-haemolytica-isolates-associated-with-bovine-respiratory-disease-from-the-german-national-resistance-monitoring-program-ge-rm-vet-2009-to-2020
#38
JOURNAL ARTICLE
Valeria Kostova, Dennis Hanke, Heike Kaspar, Stefan Fiedler, Stefan Schwarz, Henrike Krüger-Haker
Data collected from the German national resistance monitoring program GE RM -Vet showed slowly increasing prevalence of macrolide resistance among bovine respiratory disease (BRD)-associated Pasteurellacae from cattle over the last decade. The focus of this study was to analyze the genetic basis of antimicrobial resistance (AMR) and the prevalence of multidrug-resistance (MDR)-mediating integrative and conjugative elements (ICEs) in 13 German BRD-associated Mannheimia haemolytica isolates collected between 2009 and 2020 via whole-genome sequencing...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38495484/a-retrospective-analysis-of-azvudine-in-patients-with-covid-19-and-pre-existing-cancer
#39
JOURNAL ARTICLE
Fangyu Li, Keao Zheng, Xueyan Qi, Kaixia Cui, Jing Yang, Zhiying Hao
Objectives: Azvudine has been recommended as a potential treatment for the recently discovered Coronavirus disease (COVID-19) in 2019. However, the effectiveness of Azvudine in individuals who have both COVID-19 and pre-existing cancer remains uncertain. Consequently, we undertook a retrospective analysis to evaluate the clinical efficacy of Azvudine therapy in hospitalized patients with COVID-19 and pre-existing cancer. Methods: This is a single-center retrospective analysis of patients diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, selected from patients admitted to a specialist oncology hospital between June 1, 2022 to June 31, 2023 with positive RT-PCR and pre-existing cancer...
2024: Journal of Cancer
https://read.qxmd.com/read/38495462/rejection-in-liver-transplantation-recipients
#40
JOURNAL ARTICLE
Haripriya Maddur, Nicole Wilson, Pallavi Patil, Sumeet Asrani
Rejection following liver transplantation continues to impact transplant recipients although rates have decreased over time with advances in immunosuppression management. The diagnosis of rejection remains challenging with liver biopsy remaining the reference standard for diagnosis. Proper classification of rejection type and severity is imperative as this guides management and ultimately graft preservation. Future areas of promise include non-invasive testing for detection of rejection to reduce the morbidity associated with invasive testing and further advances in immunosuppression management to reduce toxicities associated with immunosuppression while minimizing rejection related morbidity...
2024: Journal of Clinical and Experimental Hepatology
keyword
keyword
50120
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.