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https://www.readbyqxmd.com/read/27922233/diagnosis-of-cystic-fibrosis-with-chloride-meter-sherwood-m926s-chloride-analyzer%C3%A2-and-sweat-test-analysis-system-cf%C3%AE-collection-system%C3%A2-compared-to-the-gibson-cooke-method
#1
Nagehan Emiralioğlu, Uğur Özçelik, Ebru Yalçın, Deniz Doğru, Nural Kiper
Sweat test with Gibson Cooke (GC) method is the diagnostic gold standard for cystic fibrosis (CF). Recently, alternative methods have been introduced to simplify both the collection and analysis of sweat samples. Our aim was to compare sweat chloride values obtained by GC method with other sweat test methods in patients diagnosed with CF and whose CF diagnosis had been ruled out. We wanted to determine if the other sweat test methods could reliably identify patients with CF and differentiate them from healthy subjects...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27921459/investigation-of-the-derivatization-conditions-for-gc-ms-metabolomics-of-biological-samples
#2
Georgios Moros, Anastasia Chrysovalantou Chatziioannou, Helen G Gika, Nikolaos Raikos, Georgios Theodoridis
AIM: Metabolomics applications represent an emerging field where significant efforts are directed. Derivatization consists prerequisite for GC-MS metabolomics analysis. METHODS: Common silylation agents were tested for the derivatization of blood plasma. Optimization of methoxyamination and silylation reactions was performed on a mixture of reference standards, consisting of 46 different metabolites. Stability of derivatized metabolites was tested at 4°C. RESULTS: Optimum results were achieved using N-methyl-N-(trimethylsilyl)trifluoroacetamide...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921340/brain-activation-during-fear-extinction-predicts-exposure-success
#3
Tali Manber Ball, Sarah E Knapp, Martin P Paulus, Murray B Stein
BACKGROUND: Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the relationship between these deficits and exposure outcome is unknown. We tested whether anxious individuals who demonstrate better extinction learning report greater anxiety reduction following brief exposure...
December 6, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27921251/skin-manifestations-of-insulin-resistance-from-a-biochemical-stance-to-a-clinical-diagnosis-and-management
#4
REVIEW
Gloria González-Saldivar, René Rodríguez-Gutiérrez, Jorge Ocampo-Candiani, José Gerardo González-González, Minerva Gómez-Flores
Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40-50% of the global population is labeled at "high risk" (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted...
December 5, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27921223/psychometric-properties-of-the-chinese-version-of-the-reproductive-concerns-after-cancer-scale-rcac-for-young-female-cancer-survivors
#5
Ting-Ting Qiao, Wei Zheng, Wei Xing, Li-Xia Zhang, Wei Zhang, Yan-Ping Shi, Xiao-Juan Chen
PURPOSE: This study aimed to translate, culturally adapt, and test the psychometric properties of the Reproductive Concerns After Cancer scale (RCAC) in young Chinese female cancer survivors. METHODS: The Chinese version of the RCAC was developed using the standard Functional Assessment of Chronic Illness Therapy (FACIT) translation methodology, and then 800 young Chinese female cancer survivors were recruited to complete the scale. The validation of the RCAC is as follows: (1) content validity was evaluated by a group of experts; (2) factor structure was assessed using confirmatory factor analysis and factorial invariance analysis; (3) convergent validity was determined by correlations with the Patient Health Questionnaire 9 (PHQ-9) and Functional Assessment of Cancer Therapy-General (FACT-G) scale; (4) internal consistency reliability was assessed using Cronbach's α coefficient; and (5) test-retest reliability was assessed using intra-class correlations...
December 5, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27921167/the-real-world-in-the-clinic-before-and-after-the-establishment-of-guidelines-for-coronary-artery-spasm-a-questionnaire-for-members-of-the-japanese-cine-angio-association
#6
Shozo Sueda, Hiroaki Kohno, Hideaki Yoshino
We investigated the clinical situations and the present knowledge of Japanese cardiologists about coronary artery spasm before and after the establishment of guidelines for this condition in the real world. A questionnaire was developed regarding the number of cases of coronary angiography, percutaneous coronary intervention, and invasive/non-invasive spasm provocation tests before (2008) and after (2014) the establishment of the Japanese Circulation Society (JCS) guidelines for coronary artery spasm and the status of spasm provocation tests...
December 5, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27921133/-evaluation-of-correction-formulas-for-tonometry-the-goldmann-applanation-tonometry-in-approximation-to-dynamic-contour-tonometry
#7
J Wachtl, M Töteberg-Harms, S Frimmel, C Kniestedt
BACKGROUND: Accurate determination of intraocular pressure (IOP) is essential for correct management of glaucoma. Goldmann applanation tonometry (GAT) is the gold standard for measuring IOP despite its limitations due to its dependence on corneal properties. With the aim of improving the accuracy of GAT readings, several correction formulas have been developed. OBJECTIVE: The aim of this study was to investigate the accuracy and clinical relevance of five correction equations for GAT...
December 5, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27921118/can-different-occlusal-positions-instantaneously-impact-spine-and-body-posture-a-pilot-study-using-rasterstereography-for-a-three-dimensional-evaluation
#8
Karoline März, Werner Adler, Ragai-Edward Matta, Linda Wolf, Manfred Wichmann, Bastian Bergauer
PURPOSE: Orthodontists influence dental occlusion directly. To suggest any link between dental occlusion and body posture is highly contentious, as evidenced by the literature. Rasterstereography, an optical technique that enables three-dimensional (3D) body measurements to be collected, has not yet been used to impartially examine whether different occlusal positions could instantaneously alter spine and body posture. We therefore set out to use this technique to nonsubjectively evaluate this question under static conditions...
December 5, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27920707/a-case-report-demonstrating-the-potential-clinical-relevance-of-liquid-tumor-biopsies-in-lung-cancer
#9
Revathi Suppiah, Bruce Gershenhorn, Maurie Markman
A 50-year-old male with advanced non-small-cell lung cancer was unable to have standard-of-care molecular testing performed at diagnosis as a result of inadequacy of the available tissue. A subsequently performed commercial liquid tumor biopsy (Foundation ACT(®)) revealed an epidermal growth factor receptor exon 19 deletion, but due to the progression of the tumor and rapid deterioration in the patient's performance status, a meaningful attempt at therapy directed to this recognized therapeutic target was not possible...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920587/defining-the-rest-interval-associated-with-the-main-sleep-period-in-actigraph-scoring
#10
Chin Moi Chow, Shi Ngar Wong, Mirim Shin, Rebecca G Maddox, Kristy-Lee Feilds, Karen Paxton, Catherine Hawke, Philip Hazell, Katharine Steinbeck
Actigraphy is increasingly used for sleep monitoring. However, there is a lack of standardized methodology for data processing and analysis, which often makes between study comparisons difficult, if not impossible, and thus open to flawed interpretation. This study evaluated a manual method for detection of the rest interval in actigraph data collected with Actiwatch 2. The rest interval (time in bed), defined as the bedtime and rise time and set by proprietary software, is an essential requirement for the estimation of sleep indices...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27920578/recording-of-hospitalizations-for-acute-exacerbations-of-copd-in-uk-electronic-health-care-records
#11
Kieran J Rothnie, Hana Müllerová, Sara L Thomas, Joht S Chandan, Liam Smeeth, John R Hurst, Kourtney Davis, Jennifer K Quint
BACKGROUND: Accurate identification of hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) within electronic health care records is important for research, public health, and to inform health care utilization and service provision. We aimed to develop a strategy to identify hospitalizations for AECOPD in secondary care data and to investigate the validity of strategies to identify hospitalizations for AECOPD in primary care data. METHODS: We identified patients with chronic obstructive pulmonary disease (COPD) in the Clinical Practice Research Datalink (CPRD) with linked Hospital Episodes Statistics (HES) data...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27920571/commercial-test-kits-for-detection-of-lyme-borreliosis-a-meta-analysis-of-test-accuracy
#12
Michael J Cook, Basant K Puri
The clinical diagnosis of Lyme borreliosis can be supported by various test methodologies; test kits are available from many manufacturers. Literature searches were carried out to identify studies that reported characteristics of the test kits. Of 50 searched studies, 18 were included where the tests were commercially available and samples were proven to be positive using serology testing, evidence of an erythema migrans rash, and/or culture. Additional requirements were a test specificity of ≥85% and publication in the last 20 years...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27920535/prevalence-of-alcohol-use-disorders-and-associated-factors-among-people-with-epilepsy-attending-amanuel-mental-specialized-hospital-addis-ababa-ethiopia
#13
Tsegereda Waja, Jemal Ebrahim, Zegeye Yohannis, Asres Bedaso
INTRODUCTION: Alcohol use disorders represent one of the leading causes of preventable death, illness, and injury in many societies throughout the world. Heavy alcohol consumption has multiple negative consequences for people with epilepsy such as precipitation of seizure, exacerbation of seizure, poor seizure control, increased side effects of antiepileptic drugs, noncompliance to antiepileptic drugs, alcohol withdrawal seizures, long-term hospital admission, status epilepticus, sudden unexpected death, and premature mortality...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27920513/bronchodilator-efficacy-of-18-%C3%AE-g-once-daily-tiotropium-inhalation-via-discair-%C3%A2-versus-handihaler-%C3%A2-in-adults-with-chronic-obstructive-pulmonary-disease-randomized-active-controlled-parallel-group-open-label-phase-iv-trial
#14
Pinar Yildiz, Mesut Bayraktaroglu, Didem Gorgun, Funda Secik
PURPOSE: To compare the bronchodilator efficacy of 18 μg once-daily tiotropium inhalation administered via Discair(®) versus HandiHaler(®) in adults with moderate-to-severe chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: Fifty-eight patients with moderate-to-severe COPD were enrolled in this randomized, active-controlled, parallel-group, open-label, Phase IV non-inferiority trial. Patients were randomly assigned to a test group (n=29, inhalation with Discair) or a reference group (n=29, inhalation with HandiHaler)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27920408/asthma-and-other-allergic-diseases-among-saudi-schoolchildren-in-najran-the-need-for-a-comprehensive-intervention-program
#15
Jobran M Alqahtani
BACKGROUND: In the last three decades, an increasing incidence of allergic diseases has been associated with increasing morbidity and mortality in children and young adults. OBJECTIVES: The study aimed to investigate the prevalence and risk factors associated with allergic diseases among Saudi schoolchildren in the southwestern Saudi region of Najran, and to determine the sensitization of patients to a set of allergens. DESIGN: Cross-sectional observational study...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27920357/use-of-a-bogus-pipeline-to-detect-men-s-underreporting-of-sexually-aggressive-behavior
#16
Emily Strang, Zoë D Peterson
Researchers rely on men's self-reports of sexually aggressive behavior to identify the prevalence and correlates of men's perpetration (i.e., their use of verbal or physical coercion to obtain sex from a nonconsenting partner). However, results from research based on men's self-reported sexual perpetration are suspect because men may intentionally conceal their sexually aggressive behavior. The current study used a Bogus Pipeline (BPL) methodology to determine whether young, community men (N = 93) intentionally underreport their use of sexually aggressive strategies on two self-report measures of perpetration...
December 4, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27920262/home-exercise-programmes-supported-by-video-and-automated-reminders-compared-with-standard-paper-based-home-exercise-programmes-in-patients-with-stroke-a-randomized-controlled-trial
#17
Kellie B Emmerson, Katherine E Harding, Nicholas F Taylor
OBJECTIVE: To determine whether patients with stroke receiving rehabilitation for upper limb deficits using smart technology (video and reminder functions) demonstrate greater adherence to prescribed home exercise programmes and better functional outcomes when compared with traditional paper-based exercise prescription. DESIGN: Randomized controlled trial comparing upper limb home exercise programmes supported by video and automated reminders on smart technology, with standard paper-based home exercise programmes...
December 5, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27920192/results-of-an-international-phosphorus-digestibility-ring-test-with-broiler-chickens
#18
M Rodehutscord, O Adeola, R Angel, P Bikker, E Delezie, W A Dozier, M Umar Faruk, M Francesch, C Kwakernaak, A Narcy, C M Nyachoti, O A Olukosi, A Preynat, B Renouf, A Saiz Del Barrio, K Schedle, W Siegert, S Steenfeldt, M M van Krimpen, S M Waititu, M Witzig
The objective of this ring test was to investigate the prececal phosphorus (P) digestibility of soybean meal (SBM) in broiler chickens using the trial protocol proposed by the World's Poultry Science Association. It was hypothesized that prececal P digestibility of SBM determined in the collaborating stations is similar. Three diets with different inclusion levels of SBM were mixed in a feed mill specialized in experimental diets and transported to 17 collaborating stations. Broiler chicks were raised on commercial starter diets according to station-specific management routine...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27920019/personalized-diabetes-management-using-electronic-medical-records
#19
Dimitris Bertsimas, Nathan Kallus, Alexander M Weinstein, Ying Daisy Zhuo
OBJECTIVE: Current clinical guidelines for managing type 2 diabetes do not differentiate based on patient-specific factors. We present a data-driven algorithm for personalized diabetes management that improves health outcomes relative to the standard of care. RESEARCH DESIGN AND METHODS: We modeled outcomes under 13 pharmacological therapies based on electronic medical records from 1999 to 2014 for 10,806 patients with type 2 diabetes from Boston Medical Center...
December 5, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27919937/primary-care-referral-for-echocardiogram-refer-in-heart-failure-a-diagnostic-accuracy-study
#20
Clare J Taylor, Andrea K Roalfe, Rachel Iles, Fd Richard Hobbs, Pelham Barton, Martin R Cowie, Russell C Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, Lynda Tait
BACKGROUND: Symptoms of breathlessness, fatigue, and ankle swelling are common in general practice but deciding which patients are likely to have heart failure is challenging. AIM: To evaluate the performance of a clinical decision rule (CDR), with or without N-Terminal pro-B type natriuretic peptide (NT-proBNP) assay, for identifying heart failure. DESIGN AND SETTING: Prospective, observational, diagnostic validation study of patients aged >55 years, presenting with shortness of breath, lethargy, or ankle oedema, from 28 general practices in England...
December 5, 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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