Yuchao Guo, Ting Zhao, Xiongyi Yao, Hongchen Ji, Yingbiao Luo, Emmanuel Sunday Okeke, Guanghua Mao, Weiwei Feng, Yao Chen, Yangyang Ding, Xiangyang Wu, Liuqing Yang
Acrylamide (ACR) is a common industrial contaminant with endocrine-disrupting toxicity. Numerous studies have indicated that females and diabetics are more sensitive to environmental contaminants. However, it remains unknown whether female diabetics are susceptible to ACR-induced toxicity and its potential mechanisms. Thus, the female ACR-exposure diabetic Balb/c mice model was established to address these issues. Results showed that ACR could induce liver injury in normal mice and cause more serious inflammatory cell infiltration, hepatocyte volume increase, and fusion in diabetic mice liver...
April 18, 2024: Chemical Research in Toxicology