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https://www.readbyqxmd.com/read/29667998/isolation-purification-characterization-and-bioactivities-of-a-glucan-from-the-root-of-pueraria-lobata
#1
Can Xu, Ningbo Qin, Chunyan Yan, Shumei Wang
The root of Pueraria lobata is considered to be a medicinal and edible herb for the treatment of diabetes, and it has a long history of application in China. To explore the constituents responsible for the anti-hyperglycemic activities of P. lobata, a water-soluble polysaccharide (PL70-1-1) was isolated and purified by using a DEAE-Cellulose 52 anion exchange column and a Sephacryl S-100 gel filtration column. Its molecular weight (2584 Da) was determined by high performance gel permeation chromatography (HPGPC)...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#2
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667855/a-disposable-tear-glucose-biosensor-part-5-improvements-in-reagents-and-tear-sampling-component
#3
Chi En Lin, Yuka Ito, Anna Deng, Jared Johns, Daniel Matloff, Curtiss B Cook, Koji Sode, Jeffrey T La Belle
A tear glucose (TG) sensor with an integrated tear sampler can provide a noninvasive method for calibrating the continuous TG contact lens and monitoring glucose. Expanding from previous work, an improved TG sensor that implements dried reagents, genetically modified glucose dehydrogenase (GDH), and a tear sampler was developed and compared against the TG sensor prepared with commercial GDH. It was found that neither sensor was affected by the tear interferents: ascorbic acid, acetaminophen, and uric acid. The sensor prepared with commercial GDH generated higher current...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29667854/response-to-discrepancies-between-blood-glucose-and-interstitial-glucose-technological-artifacts-or-physiology-a-reply
#4
Thorsten Siegmund, Lutz Heinemann, Ralph Kolassa, Andrea Thomas
No abstract text is available yet for this article.
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29667822/ypaoamides-b-and-c-linear-lipopeptides-from-an-okeania-sp-marine-cyanobacterium
#5
Kosuke Sueyoshi, Miki Yamada, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey's analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose uptake in cultured rat L6 myotubes. In particular, ypaoamide B (1) showed potent activity and activated AMP-activated protein kinase.
April 18, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29667734/celastrol-reverses-palmitic-acid-pa-caused-tlr4-md2-activation-dependent-insulin-resistance-via-disrupting-md2-related-cellular-binding-to-pa
#6
Xue Zhang, Ying Wang, Hui-Ya Ge, Yi-Jun Gu, Fan-Fan Cao, Chun-Xin Yang, Georges Uzan, Bin Peng, Deng-Hai Zhang
Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA) could bind MD2 to cause cellular inflammation. The natural compound celastrol could improve obesity, which is suggested via inhibiting inflammation, yet the detailed mechanism for celastrol is still unclear. As celastrol is reported to directly target MD2, we thought disrupting the binding between FFAs and MD2 might be one of the ways for celastrol to inhibit FFAs-caused inflammation and insulin resistance...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667703/diagnosis-and-management-practices-for-gestational-diabetes-mellitus-in-australia-cross-sectional-survey-of-the-multidisciplinary-team
#7
Nina Meloncelli, Adrian Barnett, Fiona Pelly, Susan de Jersey
BACKGROUND: Gestational diabetes mellitus (GDM) is one of the most common pregnancy disorders; however, if well managed, women with GDM experience similar pregnancy outcomes to those without. Currently, there is limited evidence on actual management practices across Australia or how multidisciplinary teams interact to optimise care. AIMS: To examine the current screening, diagnostic, task and role perceptions and management practices, as reported by members of the GDM multidisciplinary team...
April 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29667669/structural-characterization-and-antitumor-activity-of-a-novel-se-polysaccharide-from-selenium-enriched-cordyceps-gunnii
#8
Huiqing Sun, Zhenyuan Zhu, Yali Tang, Yuanyuan Ren, Qiaoying Song, Yun Tang, Yongmin Zhang
Selenium (Se) has been recognized as an essential element. Animals and humans absorb and retain more organic Se than inorganic Se. Bio-transformation is a major approach to transform inorganic Se to organic Se. Cordyceps gunnii (C. gunnii), well known as a Chinese edible and medicinal fungus, has a variety of biological functions. C. gunnii and selenium were combined through liquid-fermentation to obtain selenium-enriched C. gunnii. A novel Se-polysaccharide (SeCPS-II) was extracted from selenium-enriched C...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29667605/hierarchical-layered-double-hydroxides-with-ag-nanoparticles-modification-for-ethanol-sensing
#9
Yuxiang Qin, Liping Wang, Xiaofei Wang
Layered double hydroxides (LDHs) are recently revealed to be promising in gas sensor application due to compositional flexibility and unique 2D-interlayer channel for gas diffusion and adsorption. This work demonstrates a kind of highly porous hierarchical LDHs containing Mg2+ and Al3+ (MgAl-LDHs) for ethanol-sensing at room temperature. The MgAl-LDHs with unique flower-like hierarchical structure and mesoporous interlayer were synthesized hydrothermally using sodium dodecyl sulfate (SDS) as soft template as well as intercalating agent...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667589/a-rare-cause-of-dysregulated-metabolic-syndrome-cortisol-producing-adrenocortical-carcinoma
#10
L Saes, I A Boere, J Hofland, M Mulder, R A Feelders
Adrenocortical carcinoma is a rare and highly malignant disease which can cause hypercortisolism leading to dysregulation of blood pressure and glucose levels. Most patients present with advanced disease. We describe the classic presentation of a functional adrenocortical carcinoma in a patient with metabolic syndrome.
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29667496/reducing-prolonged-sedentary-time-using-a-treadmill-desk-acutely-improves-cardiometabolic-risk-markers-in-male-and-female-adults
#11
Rachael B Champion, Lindsey R Smith, Jennifer Smith, Bogdana Hirlav, Benjamin D Maylor, Stephanie L White, Daniel P Bailey
This study evaluated the acute effects of interrupting prolonged sitting with an accumulated 2 h of light-intensity walking on postprandial cardiometabolic risk markers. In this randomised crossover trial, 24 participants (twelve males) aged 18-55 years took part in two, 6.5 h conditions: 1) prolonged sitting (SIT) and 2) sitting interrupted hourly with 20 min light-intensity treadmill desk walking at between 1.2-3.5 km/h-1 (INT-SIT). Standardized meals were provided at 0 h and 3 h. Blood samples and blood pressure measures were taken hourly...
April 18, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29667406/identification-of-novel-bioactive-peptides-with-%C3%AE-amylase-inhibitory-potential-from-enzymatic-protein-hydrolysates-of-red-seaweed-porphyra-spp
#12
Habtamu Admassu, Mohammed A A Gasmalla, Ruijin Yang, Wei Zhao
Inhibition of α-amylase enzyme is one therapeutic approach in lowering glucose level in the blood to manage diabetes mellitus. In this study α-amylase inhibitory peptides were identified from proteolytic enzymes hydrolysates of red seaweed laver (Porphyra species) using consecutive chromatographic techniques. In the resultant fractions from RP-HPLC (D1-10), D2 inhibited α-amylase activity (88.67 ± 1.05 %) significantly (p ≤ 0.5) at 1mg/mL protein concentration. A mass spectrometry (ESI-Q-TOF- MS) analysis was used to identify peptides from this fraction...
April 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29667177/adverse-placental-effects-of-valproic-acid-studies-in-perfused-human-placentas
#13
Miriam Rubinchik-Stern, Miriam Shmuel, Jacob Bar, Michal Kovo, Sara Eyal
OBJECTIVE: In utero exposure to valproic acid (VPA) has been associated with worse pregnancy outcomes compared to all other antiepileptic drugs. We have previously shown that VPA alters the expression of placental transporters for hormones and nutrients in vitro and in pregnant mice. Here, our aim was to characterize the effects of short exposure to VPA on the expression of carriers for compounds essential for fetal development in human placentas ex vivo, under controlled conditions...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29667130/beneficial-effects-of-the-calcium-channel-blocker-ctk-01512-2-in-a-mouse-model-of-multiple-sclerosis
#14
Rodrigo B M Silva, Samuel Greggio, Gianina T Venturin, Jaderson C da Costa, Marcus V Gomez, Maria M Campos
Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of this molecule in the mouse model of experimental autoimmune encephalomyelitis (EAE). The effects of CTK 01512-2 were compared to those displayed by ziconotide-a selective N-type VGCC blocker clinically used for chronic pain-and fingolimod-a drug employed for MS treatment...
April 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29667109/ideal-cardiovascular-health-among-ghanaian-populations-in-three-european-countries-and-rural-and-urban-ghana-the-rodam-study
#15
Benjamin van Nieuwenhuizen, Mohammad Hadi Zafarmand, Erik Beune, Karlijn Meeks, Ama de-Graft Aikins, Juliet Addo, Ellis Owusu-Dabo, Frank P Mockenhaupt, Silver Bahendeka, Matthias B Schulze, Ina Danquah, Joachim Spranger, Kerstin Klipstein-Grobusch, Lambert Tetteh Appiah, Liam Smeeth, Karien Stronks, Charles Agyemang
Cardiovascular health (CVH) is a construct defined by the American Heart Association (AHA) as part of its 2020 Impact Goal definition. CVH has, until now, not been evaluated in Sub-Saharan African populations. The aim of this study was to investigate differences in the prevalence of ideal CVH and its constituent metrics among Ghanaians living in rural and urban Ghana and Ghanaian migrants living in three European countries. The AHA definition of CVH is based on 7 metrics: smoking, body mass index, diet, physical activity, blood pressure, total cholesterol, and fasting plasma glucose...
April 17, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29667107/a-computer-based-glucose-management-system-reduces-the-incidence-of-forgotten-glucose-measurements-a-retrospective-observational-study
#16
Tsuyoshi Okura, Kei Teramoto, Rie Koshitani, Yohei Fujioka, Yusuke Endo, Masaru Ueki, Masahiko Kato, Shin-Ichi Taniguchi, Hiroshi Kondo, Kazuhiro Yamamoto
INTRODUCTION: Frequent glucose measurements are needed for good blood glucose control in hospitals; however, this requirement means that measurements can be forgotten. We developed a novel glucose management system using an iPod® and electronic health records. METHODS: A time schedule system for glucose measurement was developed using point-of-care testing, an iPod® , and electronic health records. The system contains the glucose measurement schedule and an alarm sounds if a measurement is forgotten...
April 17, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29667027/neonatal-overfeeding-impairs-differentiation-potential-of-mice-subcutaneous-adipose-mesenchymal-stem-cells
#17
Isabelle Dias, Ísis Salviano, André Mencalha, Simone Nunes de Carvalho, Alessandra Alves Thole, Laís Carvalho, Erika Cortez, Ana Carolina Stumbo
Nutritional changes in the development (intrauterine life and postnatal period) may trigger long-term pathophysiological complications such as obesity and cardiovascular disease. Metabolic programming leads to organs and tissues modifications, including adipose tissue, with increased lipogenesis, production of inflammatory cytokines, and decreased glucose uptake. However, stem cells participation in adipose tissue dysfunctions triggered by overfeeding during lactation has not been elucidated. Therefore, this study was the first to evaluate the effect of metabolic programming on adipose mesenchymal stem cells (ASC) from mice submitted to overfeeding during lactation, using the litter reduction model...
April 17, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29666986/impaired-fasting-glucose-is-associated-with-unfavorable-outcome-in-ischemic-stroke-patients-treated-with-intravenous-alteplase
#18
E Osei, S Fonville, A A M Zandbergen, P J Koudstaal, D W J Dippel, H M den Hertog
OBJECTIVES: Hyperglycemia on admission and diabetes mellitus type II are associated with unfavorable outcome in stroke patients. We studied whether impaired fasting glucose (IFG) is associated with unfavorable outcome in ischemic stroke patients treated with intravenous alteplase as well and if IFG is a stronger prognostic factor than hyperglycemia on admission. METHODS: We studied 220 consecutive patients with ischemic stroke treated with intravenous alteplase...
April 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29666912/magnetic-bead-capture-dna-glucose-loaded-nanoliposomes-for-amplifying-the-glucometer-signal-in-the-rapid-screening-of-hepatitis-c-virus-rna
#19
Haijian Tu, Kun Lin, Yongzhi Lun, Liuming Yu
A digital detection strategy based on a portable personal glucometer (PGM) was developed for the simple, rapid, and sensitive detection of hepatitis C virus (HCV) RNA, involving the release of glucose-loaded nanoliposomes due to coupling-site-specific cleavage by the endonuclease BamHI. The glucose-loaded nanoliposomes were synthesized using a reversed-phase evaporation method and provided an amplified signal at the PGM in the presence of HCV RNA. Initially, a 21-mer oligonucleotide complementary to HCV RNA was covalently conjugated to a magnetic bead through the amino group at the 5' end of the oligonucleotide, and then bound to a glucose-loaded liposome by typical carbodiimide coupling at its 3' end...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29666865/preparation-of-lactic-acid-and-glucose-responsive-poly-%C3%AE%C2%B5-caprolactone-b-poly-ethylene-oxide-block-copolymer-micelles-using-phenylboronic-ester-as-a-sensitive-block-linkage
#20
David Vrbata, Mariusz Uchman
The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO). The PCL block with pendant phenylboronic acid (PCLBA) was synthesized by combining ε-caprolactone (ε-CL) ring-opening polymerisation (ROP), using 4-hydroxymethyl(phenylboronic) acid pinacolate as the initiator, and pinacol deprotection...
April 18, 2018: Nanoscale
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