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https://www.readbyqxmd.com/read/28655017/prevalence-and-ethnic-pattern-of-diabetes-and-prediabetes-in-china-in-2013
#1
Limin Wang, Pei Gao, Mei Zhang, Zhengjing Huang, Dudan Zhang, Qian Deng, Yichong Li, Zhenping Zhao, Xueying Qin, Danyao Jin, Maigeng Zhou, Xun Tang, Yonghua Hu, Linhong Wang
Importance: Previous studies have shown increasing prevalence of diabetes in China, which now has the world's largest diabetes epidemic. Objectives: To estimate the recent prevalence and to investigate the ethnic variation of diabetes and prediabetes in the Chinese adult population. Design, Setting, and Participants: A nationally representative cross-sectional survey in 2013 in mainland China, which consisted of 170 287 participants. Exposures: Fasting plasma glucose and hemoglobin A1c levels were measured for all participants...
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28654913/insulin-like-growth-factor-1-is-a-negative-modulator-of-glucagon-secretion
#2
Elettra Mancuso, Gaia C Mannino, Concetta Di Fatta, Anastasia Fuoco, Rosangela Spiga, Francesco Andreozzi, Giorgio Sesti
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose. Insulin-like growth factor-I (IGF-1) has elevated homology with insulin, and regulates pancreatic β-cells insulin secretion. Insulin and IGF-1 receptors share considerable structure homology and function. We hypothesized the existence of a mechanism linking the inhibition of α-cells glucagon secretion to IGF-1. Herein, we evaluated the association between plasma IGF-1 and glucagon levels in 116 nondiabetic adults...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654887/glucose-oxidase-initiated-cascade-catalysis-for-sensitive-impedimetric-aptasensor-based-on-metal-organic-frameworks-functionalized-with-pt-nanoparticles-and-hemin-g-quadruplex-as-mimicking-peroxidases
#3
Xingxing Zhou, Shijing Guo, Jiaxi Gao, Jianmin Zhao, Shuyan Xue, Wenju Xu
Based on cascade catalysis amplification driven by glucose oxidase (GOx), a sensitive electrochemical impedimetric aptasensor for protein (carcinoembryonic antigen, CEA as tested model) was proposed by using Cu-based metal-organic frameworks functionalized with Pt nanoparticles, aptamer, hemin and GOx (Pt@CuMOFs-hGq-GOx). CEA aptamer loaded onto Pt@CuMOFs was bound with hemin to form hemin@G-quadruplex (hGq) with mimicking peroxidase activity. Through sandwich-type reaction of target CEA and CEA aptamers (Apt1 and Apt2), the obtained Pt@CuMOFs-hGq-GOx as signal transduction probes (STPs) was captured to the modified electrode interface...
June 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28654886/bimetallic-pt-au-nanocatalysts-electrochemically-deposited-on-boron-doped-diamond-electrodes-for-nonenzymatic-glucose-detection
#4
Siriwan Nantaphol, Takeshi Watanabe, Naohiro Nomura, Weena Siangproh, Orawon Chailapakul, Yasuaki Einaga
The enormous demand for medical diagnostics has encouraged the fabrication of high- performance sensing platforms for the detection of glucose. Nonenzymatic glucose sensors are coming ever closer to being used in practical applications. Bimetallic catalysts have been shown to be superior to single metal catalysts in that they have greater activity and selectivity. Here, we demonstrate the preparation, characterization, and electrocatalytic characteristics of a new bimetallic Pt/Au nanocatalyst. This nanocatalyst can easily be synthesized by electrodeposition by sequentially depositing Au and Pt on the surface of a boron-doped diamond (BDD) electrode...
June 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28654853/association-of-matrix-%C3%AE-carboxyglutamic-acid-protein-levels-with-insulin-resistance-and-lp-a-in-diabetes-a-cross-sectional-study
#5
Stavros Antonopoulos, Maria Mylonopoulou, Angeliki M Angelidi, Antonis A Kousoulis, Nicholas Tentolouris
AIMS: The risk of cardiovascular disease (CVD) and mortality is increased in patients with chronic kidney disease (CKD), with a background role of vascular calcification in the development of CVD also reported. Studies have demonstrated that high lipoprotein(a) (Lp(a)) levels accelerate the development of atherosclerolsis and are potentially involved in the vascular calcification. Matrix Gla Protein (MGP) seems to play an important role in vascular calcification. The aim of the study was to examine the potential association of MGP concentrations with Lp(a) and insulin resistance...
June 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28654846/diabetes-mellitus-is-associated-with-late-onset-post-stroke-depression
#6
Yu Zhang, Ji-Rong He, Huai-Bin Liang, Wen-Jing Lu, Guo-Yuan Yang, Jian-Rong Liu, Li-Li Zeng
OBJECTIVE: To explore the associated factors of late-onset post-stroke depression (PSD). METHODS: A total of 251 patients with acute ischemic stroke were recruited. The evaluation of depression was performed 2 weeks after ischemia. 206 patients showing no depression in 2 weeks were followed up. They were divided into late-onset PSD group and non-depressed group by clinical interview with Hamilton depression scale score 3 months after stroke. On the first day following hospitalization, the clinical data including age, gender, educational level and vascular risk factors were recorded...
June 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28654829/fructose-intake-exacerbates-the-contractile-response-elicited-by-norepinephrine-in-mesenteric-vascular-bed-of-rats-via-increased-endothelial-prostanoids
#7
Glauciene J Sousa, Phablo Wendell C Oliveira, Breno V Nogueira, Antônio F Melo, Thaís de Oliveira Faria, Eduardo Frizera Meira, José G Mill, Nazaré S Bissoli, Marcelo P Baldo
Chronic fructose intake induces major cardiovascular and metabolic disturbances and is associated with the development of hypertension due to changes in vascular function. We hypothesized that high fructose intake for 6 weeks would cause metabolic syndrome and lead to initial vascular dysfunction. Male Wistar rats were assigned to receive fructose (FRU, 10%) or drinking water (CON) for 6 weeks. Systolic blood pressure was evaluated by tail plethysmography. Fasting glucose, insulin and glucose tolerance were measured at the end of the follow-up...
June 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28654680/serum-fatty-acid-binding-protein-4-fabp4-concentration-is-associated-with-insulin-resistance-in-peripheral-tissues-a-clinical-study
#8
Risa Nakamura, Tsuyoshi Okura, Yohei Fujioka, Keisuke Sumi, Kazuhiko Matsuzawa, Shoichiro Izawa, Etsuko Ueta, Masahiko Kato, Shin-Ichi Taniguchi, Kazuhiro Yamamoto
Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with insulin sensitivity in skeletal muscle, Adiponectin and other parameters, such as fatty acid-binding protein (FABP4), have been reported to regulate insulin resistance, but it remains unclear which factor mostly affects insulin resistance in T2DM. In this cross-sectional study, we evaluated the relationships between several kinds of biomarkers and insulin resistance, and insulin secretion in T2DM and healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28654627/effect-of-programmed-exercise-on-insulin-sensitivity-in-postmenopausal-women-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Juan Bueno-Notivol, Julia Calvo-Latorre, Vanesa Alonso-Ventura, Vinay Pasupuleti, Adrian V Hernandez, Faustino R Pérez-López
OBJECTIVE: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of programmed exercise for at least 12 weeks, in postmenopausal women on insulin sensitivity-related outcomes (ISROs), including fasting insulin, C-peptide, insulin growth factor (IGF-1) and IGF-binding protein (IGFBP-3), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), and anthropometric variables. METHODS: Searches were conducted in PubMed-Medline, Embase, Scopus, Web of Science, and Cochrane Library from inception through May 3, 2016, for studies published in all languages...
June 26, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28654385/3d-fusion-framework-for-infarction-and-angiogenesis-analysis-in-a-myocardial-infarct-minipig-model
#10
Xu Zhenzhen, Bo Tao, Yu Li, Jun Zhang, Xiaochao Qu, Feng Cao, Jimin Liang
The combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]DG) positron emission tomography (PET)/CT, and [(68)Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([(68)Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654383/brain-and-brown-adipose-tissue-metabolism-in-transgenic-tg2576-mice-models-of-alzheimer-disease-assessed-using-18-f-fdg-pet-imaging
#11
Robert A Coleman, Christopher Liang, Rima Patel, Sarah Ali, Jogeshwar Mukherjee
OBJECTIVE: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid plaques. We report (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) imaging of brain and intrascapular brown adipose tissue (IBAT) in transgenic mice 2576 (Tg2576) and wild-type (WT) mice. METHODS: Transgenic Tg2576 mice and WT mice, >18 months were injected intraperitonally with ≈ 25 to 30 MBq (18)F-FDG while awake...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654381/preclinical-multimodal-molecular-imaging-using-18-f-fdg-pet-ct-and-mri-in-a-phase-i-study-of-a-knee-osteoarthritis-in-in-vivo-canine-model
#12
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent (18)F-fluoro-d-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654314/cross-validation-of-a-glucose-insulin-glucagon-pharmacodynamics-model-for-simulation-using-data-from-patients-with-type-1-diabetes
#13
Sabrina Lyngbye Wendt, Ajenthen Ranjan, Jan Kloppenborg Møller, Signe Schmidt, Carsten Boye Knudsen, Jens Juul Holst, Sten Madsbad, Henrik Madsen, Kirsten Nørgaard, John Bagterp Jørgensen
BACKGROUND: Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determine the glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon. METHODS: Eight type 1 diabetes (T1D) patients each received a subcutaneous (SC) bolus of insulin on four study days to induce mild hypoglycemia followed by a SC bolus of saline or 100, 200, or 300 µg of glucagon...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28654309/effect-of-oral-branched-chain-amino-acid-supplementation-on-postoperative-blood-lactate-levels-in-patients-undergoing-pancreatoduodenectomy
#14
Yoshihide Nanno, Hirochika Toyama, Sachio Terai, Takuya Mizumoto, Motofumi Tanaka, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
BACKGROUND: Elevations in blood lactate levels have been associated with poor postoperative outcome. The aim of the present study was to determine if preoperative supplementation with branched-chain amino acids (BCAA) decreases postoperative blood lactate levels in patients undergoing pancreatoduodenectomy. METHODS: The cases of 223 consecutive patients who underwent pancreatoduodenectomy were retrospectively reviewed. Postoperative blood lactate levels in patients who were treated with BCAA supplementation before pancreatoduodenectomy (December 2011-December 2014) were compared with levels in patients who were not pretreated (January 2008-November 2011)...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28654305/commentary-regarding-shapiro-nonadjunctive-use-of-continuous-glucose-monitors-for-insulin-dosing
#15
David Price
The FDA recently expanded the approved use of Dexcom's G5 Mobile continuous glucose monitoring (CGM) system to allow for diabetes treatment decisions. This decision is expected to reduce the burden of SMBG testing and increase the adoption and persistent use of CGM. The safety of nonadjunctive CGM use was questioned because of sporadic large discrepancies between CGM and SMBG values. These data were viewed in the context of complaints found in the FDA MAUDE database and social media postings. This commentary provides additional perspective on the inferences that can be drawn from these reports and the risk of nonadjunctive use of CGM data...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28654261/astragalin-reduces-hexokinase-2-through-increasing-mir-125b-to-inhibit-the-proliferation-of-hepatocellular-carcinoma-cells-in-vitro-and-in-vivo
#16
Wei Li, Ji Hao, Lang Zhang, Zhuo Cheng, Xukun Deng, Guangwen Shu
Astragalin (ASG) can be found in a variety of food components. ASG exhibits cytotoxic effects on several different types of malignant cells. However, its effects on hepatocellular carcinoma (HCC) cells and the underlying molecular mechanisms have remained to be fully elucidated. Here, we revealed that ASG remarkably suppressed the proliferation of HCC cells. In HCC cells, ASG inhibited glucose glycolysis and promoted oxidative phosphorylation, resulting in a surge of reactive oxygen species (ROS). Mechanistically, ASG suppressed the expression of hexokinase 2 (HK2)...
June 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28654165/using-personalized-medicine-in-the-management-of-diabetes-mellitus
#17
Nina Elk, Otito F Iwuchukwu
Diabetes mellitus is a worldwide problem of immense pharmacoeconomic burden. The multifactorial and complex nature of the disease lends itself to personalized pharmacotherapeutic approaches to treatment. Variability in individual risk and subsequent development of diabetes have been reported, in addition to differences in response to the many oral glucose lowering therapies currently available for diabetes pharmacotherapy. Pharmacogenomic studies have attempted to uncover the heritable components of individual variability in risk susceptibility and response to pharmacotherapy...
June 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28654122/dissipation-of-self-assemblies-by-fusion-of-complementary-gels-an-elegant-strategy-for-programmed-enzymatic-reactions
#18
Deep Mandal, Pritam Choudhury, Deblina Sarkar, Prasanta Kumar Das
Cholesterol based phenylboronic acid and glucose tailored complementary gels were developed which underwent mutual self-destruction upon mixing due to the formation of a boronate-diol adduct. This dissipation of the complementary gels was employed in a programmed enzymatic reaction and in pro-drug activation.
June 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28654105/facile-detection-of-glucose-in-human-serum-employing-silver-ion-guided-surface-enhanced-raman-spectroscopy-signal-amplification
#19
Cuicui Fu, Sila Jin, Joohee Oh, Shuping Xu, Young Mee Jung
A facile surface-enhanced Raman scattering (SERS) sensor based on a silver-ion-mediated amplification effect was designed for the determination of glucose concentration. In this approach, 4-aminothiophenol (4-ATP) molecules assembled on the surface of a gold wafer (Au wafer@4-ATP) act not only as Raman tags but also as linkage agents. Silver nanoparticles marked with cysteamine (AgNP@cys) were used as the SERS enhancement components because they could be bound to the Au wafer@4-ATP in the presence of silver ions through the formation of N → Ag(+) ← N coordination compounds...
June 27, 2017: Analyst
https://www.readbyqxmd.com/read/28654087/caffeine-inhibits-hypothalamic-a1r-to-excite-oxytocin-neuron-and-ameliorate-dietary-obesity-in-mice
#20
Liufeng Wu, Jia Meng, Qing Shen, Yi Zhang, Susu Pan, Zhuo Chen, Ling-Qiang Zhu, Youming Lu, Yuan Huang, Guo Zhang
Caffeine, an antagonist of the adenosine receptor A1R, is used as a dietary supplement to reduce body weight, although the underlying mechanism is unclear. Here, we report that adenosine level in the cerebrospinal fluid, and hypothalamic expression of A1R, are increased in the diet-induced obesity (DIO) mouse. We find that mice with overexpression of A1R in the neurons of paraventricular nucleus (PVN) of the hypothalamus are hyperphagic, have glucose intolerance and high body weight. Central or peripheral administration of caffeine reduces the body weight of DIO mice by the suppression of appetite and increasing of energy expenditure...
June 27, 2017: Nature Communications
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