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https://www.readbyqxmd.com/read/28738444/protein-coating-of-dna-nanostructures-for-enhanced-stability-and-immunocompatibility
#1
Henni Auvinen, Hongbo Zhang, Nonappa, Alisa Kopilow, Elina H Niemelä, Sami Nummelin, Alexandra Correia, Hélder A Santos, Veikko Linko, Mauri A Kostiainen
Fully addressable DNA nanostructures, especially DNA origami, possess huge potential to serve as inherently biocompatible and versatile molecular platforms. However, their use as delivery vehicles in therapeutics is compromised by their low stability and poor transfection rates. This study shows that DNA origami can be coated by precisely defined one-to-one protein-dendron conjugates to tackle the aforementioned issues. The dendron part of the conjugate serves as a cationic binding domain that attaches to the negatively charged DNA origami surface via electrostatic interactions...
July 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28738230/fluorinated-tripodal-receptors-for-potentiometric-chloride-detection-in-biological-fluids
#2
Nadezda Pankratova, Maria Cuartero, Laura A Jowett, Ethan N W Howe, Philip A Gale, Eric Bakker, Gastón A Crespo
Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective complexation of chloride, nitrate, bicarbonate and sulfate anions via hydrogen bonding. The potentiometric properties of urea and thiourea-based fluorinated tripodal receptors are explored here for the first time, in light of the need for reliable sensors for chloride monitoring in undiluted biological fluids...
July 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28737821/structure-and-reactivity-of-ru-ii-terpy-n-n-cl-cl-complexes-consequences-for-biological-applications
#3
Marta Chrzanowska, Anna Katafias, Olga Impert, Anna Kozakiewicz, Andrzej Surdykowski, Paulina Brzozowska, Alicja Franke, Achim Zahl, Ralph Puchta, Rudi van Eldik
The crystal structures of [Ru(II)(terpy)(bipy)Cl]Cl·2H2O and [Ru(II)(terpy)(en)Cl]Cl·3H2O, where terpy = 2,2':6',2''-terpyridine, bipy = 2,2'-bipyridine and en = ethylenediamine, were determined and compared to the structure of the complexes in solution obtained by multi-nuclear NMR spectroscopy in DMSOd-6 as a solvent. In aqueous solution, both chlorido complexes aquate fully to the corresponding aqua complexes, viz. [Ru(II)(terpy)(bipy)(H2O)](2+) and [Ru(II)(terpy)(en)(H2O)](2+), within ca. 2 h and ca. 2 min at 37 °C, respectively...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28735627/inhibition-of-indoleamine-2-3-dioxygenase-activity-by-fatty-acids-and-prostaglandins-a-structure-function-analysis
#4
M Costabile, N K Bassal, J P Gerber, B P Hughes
Indoleamine 2,3-dioxygenase-1 (IDO-1) catalyses the first and rate-limiting step in the metabolism of L-tryptophan. Degradation of L-Trp leads to the production of several immunosuppressive metabolites, including N-formyl kynurenine and kynurenine (Kyn). Apart from a normal physiological role, IDO-1 has also been identified to play a crucial role in immune suppression and tumour induced tolerance. Indeed, many primary tumours express high levels of IDO-1 compared to normal cells of the same stroma. IDO-1 is accepted as being an inducible negative regulator of T cell viability, proliferation and activation...
July 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28734997/influence-of-preparation-fitting-and-cementation-on-the-vitro-performance-and-fracture-resistance-of-cad-cam-crowns
#5
Martin Rosentritt, Verena Preis, Michael Behr, Sebastian Hahnel
OBJECTIVES: To investigate debonding and stability of CAD/CAM composite crowns as a function of (a) preparation design, (b) fitting parameters of the milling process, and (c) type of cementation. METHODS: Extracted human molars were prepared providing either retentive design (R) or no retention (NR). After digitalization, full-contour crowns were milled using either optimal (OF) or reduced (RF) fitting parameters. A total of 112 crowns were milled from the composite materials Lava Ultimate (L) and Grandio Blocs (G) and a ceramic reference...
July 19, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28734877/enzymatic-and-free-radical-formation-of-cis-and-trans-epoxyeicosatrienoic-acids-in-vitro-and-in-vivo
#6
Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid (AA) oxidation that have important cardioprotective and signaling properties. AA is an ω -6 polyunsaturated fatty acid (PUFA) that is prone to autoxidation. Although hydroperoxides and isoprostanes are major autoxidation products of AA, EETs are also formed from the largely overlooked peroxyl radical addition mechanism. While autoxidation yields both cis- and trans-EETs, cytochrome P450 (CYP) epoxygenases have been shown to exclusively catalyze the formation of all regioisomer cis-EETs, on each of the double bonds...
July 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28734605/surface-bonded-amide-functionalized-imidazolium-ionic-liquid-as-stationary-phase-for-hydrophilic-interaction-liquid-chromatography
#7
Lizhen Qiao, Wangjie Lv, Mengmeng Chang, Xianzhe Shi, Guowang Xu
The amide group modified silica materials are popular stationary phases for hydrophilic interaction liquid chromatography (HILIC). Meanwhile, surface-confined imidazolium ionic liquids (ILs) have been proved to be useful HILIC stationary phases and possess many unique properties. In this study, the synthesis of an amide-functionalized imidazolium IL was conducted which was then bonded onto silica surface to obtain a novel imidazolium-embedded amide stationary phase for HILIC. The combination of the amide group and imidazolium IL moiety might bring some advantages in selectivity or retention and therefore extended its applications...
July 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28734206/theoretical-investigation-of-the-conformational-space-of-baicalin
#8
Juan J Martínez Medina, Evelina G Ferrer, Patricia A M Williams, Nora B Okulik
Flavonoids are a large group of polyphenolic compounds ubiquitously present in plants. They are important components of human diet. They are recognized as potential drug candidates to be used in the treatment and prevention of a lot of pathological disorders, due to their protective effects. Baicalin (7-glucuronic acid 5, 6-dihydroxyflavone) is one of the main single active constituents isolated from the dried roots of Scutellaria baicalensis Georgi. The great interest on this flavonoid is due to its various pharmacological properties, such as antioxidant, antimicrobial, anti-inflammatory, anticancer and so on, and its high accumulation in the roots of S...
July 11, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28732915/effect-of-silver-contents-in-cellulose-nanocrystal-silver-nanohybrids-on-phbv-crystallization-and-property-improvements
#9
Heng Zhang, Hou-Yong Yu, Chuang Wang, Juming Yao
Ternary nanocomposites including cellulose nanocrystals/silver nanohybrids (CNC-Ag) and biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) were prepared by using solution casting. The effect of different AgNPs contents in the nanohybrids on crystallization ability and properties of PHBV was comprehensively investigated. Compared to binary PHBV/CNC nanocomposite, the ternary nanocomposites with high AgNPs contents showed larger improvements in the thermal stability, mechanical, barrier, overall migration and antibacterial properties...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28732768/molecular-characterization-and-expression-analysis-of-four-fish-specific-cc-chemokine-receptors-ccr4la-ccr4lc1-ccr4lc2-and-ccr11-in-rainbow-trout-oncorhynchus-mykiss
#10
Zhitao Qi, Jason W Holland, Yousheng Jiang, Christopher J Secombes, Pin Nie, Tiehui Wang
The chemokine and chemokine receptor networks regulate leukocyte trafficking, inflammation, immune cell differentiation, cancer and other biological processes. Comparative immunological studies have revealed that both chemokines and their receptors have expanded greatly in a species/lineage specific way. Of the 10 human CC chemokine receptors (CCR1-10) that bind CC chemokines, orthologues only to CCR6, 7, 9 and 10 are present in teleost fish. In this study, four fish-specific CCRs, termed as CCR4La, CCR4Lc1, CCR4Lc2 and CCR11, with a close link to human CCR1-5 and 8, in terms of amino acid homology and syntenic conservation, have been identified and characterized in rainbow trout (Oncorhynchus mykiss)...
July 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28732033/spatial-and-simultaneous-representative-seroprevalence-of-anti-toxoplasma-gondii-antibodies-in-owners-and-their-domiciled-dogs-in-a-major-city-of-southern-brazil
#11
Aline do Nascimento Benitez, Felippe Danyel Cardoso Martins, Marcelle Mareze, Nelson Jessé Rodrigues Santos, Fernanda Pinto Ferreira, Camila Marinelli Martins, João Luis Garcia, Regina Mitsuka-Breganó, Roberta Lemos Freire, Alexander Welker Biondo, Italmar Teodorico Navarro
Toxoplasmosis, caused by Toxoplasma gondii, has traditionally been considered an important water and foodborne protozoonosis with important public health considerations. Although felids play a well-established role as definitive hosts, canine epidemiological involvement in the parasite's life cycle remains questionable and controversial. The increasing closeness of the human-dog bond, particularly seen in urban settings, has been recognized as a historically unprecedented worldwide movement. Sharing daily lives in the same households, dogs may be exposed to similar associated risks of T...
2017: PloS One
https://www.readbyqxmd.com/read/28730253/fatal-hypersensitivity-pneumonitis-after-chemical-occupational-exposure
#12
Milena Adina Man, Sorin Claudiu Man, Nicoleta Ştefania Motoc, Carmen Monica Pop, Antigona Carmen Trofor
Hypersensitivity pneumonitis (HP; extrinsic allergic alveolitis) is a rare non-immunoglobulin E (IgE)-mediated inflammatory lung disease caused by inhalation exposure (occupational, recreational or ordinary home exposure). A 36-year-old female patient, without significant medical history, is referred to an outpatient pulmonology clinic for dry cough, shortness of breath, fever, fatigue and weight loss. Chest high-resolution computed tomography (HRCT) was performed, and significant lung fibrosis (especially centrilobular and interlobular in bilateral "thick lines"), traction bronchiectasis and alveolitis in both superior lobes are described...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28728917/global-alteration-of-the-drug-binding-pocket-of-human-p-glycoprotein-abcb1-by-substitution-of-fifteen-conserved-residues-reveals-a-negative-correlation-between-substrate-size-and-transport-efficiency
#13
Shahrooz Vahedi, Eduardo E Chufan, Suresh V Ambudkar
P-glycoprotein (P-gp), an ATP-dependent efflux pump, is linked to the development of multidrug resistance in cancer cells. However, the drug-binding sites and translocation pathways of this transporter are not yet well-characterized. We recently demonstrated the important role of tyrosine residues in regulating P-gp ATP hydrolysis via hydrogen bond formations with high affinity modulators. Since tyrosine is both a hydrogen bond donor and acceptor, and non-covalent interactions are key in drug transport, in this study we investigated the global effect of enrichment of tyrosine residues in the drug-binding pocket on the drug binding and transport of P-gp...
July 17, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28727319/novel-evaluation-and-treatment-techniques-for-white-spot-lesions-an-in-vitro-study
#14
T A Bakhsh, A S Bakry, M M Mandurah, M A Abbassy
OBJECTIVE: White spot lesions (WSLs) are commonly seen during and after orthodontic treatment. Therefore, the objective of this in vitro study was to assess the effect of 45S5-bioglass in remineralizing WSLs using cross-polarization optical coherence tomography (CP-OCT) and confirm the findings by micro-hardness test. METHODS: Ceramic orthodontic brackets were bonded to the buccal surface of 45 human premolars with Transbond XT primer followed by Transbond PLUS according to the manufacturer's instructions...
August 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28726920/pheomelanin-molecular-vibration-is-associated-with-mitochondrial-ros-production-in-melanocytes-and-systemic-oxidative-stress-and-damage
#15
Ismael Galván, Alberto Jorge, María García-Gil
Vibrations in covalent bonds affect electron delocalization within molecules, as reported in polymers. If synthesized by living cells, the electron delocalization of polymers affects the stabilization of cellular free radicals, but biomolecular vibration has never been considered a potential source of cytotoxicity. Here we show that the vibrational characteristics of natural pheomelanin and eumelanin contribute to feather color expression in four poultry breeds with different melanin-based pigmentation patterns, but only the vibrational characteristics of pheomelanin are related to the production of reactive oxygen species (ROS) in the mitochondria of melanocytes and to systemic levels of cellular oxidative stress and damage...
July 20, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28726740/cyclic-peptides-as-novel-therapeutic-microbicides-engineering-of-human-defensin-mimetics
#16
REVIEW
Annarita Falanga, Ersilia Nigro, Margherita Gabriella De Biasi, Aurora Daniele, Giancarlo Morelli, Stefania Galdiero, Olga Scudiero
Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents. Antimicrobial peptides appear to be key components of innate defences against bacteria, viruses, and fungi. Among the others, defensins possess a strong microbicidial activity. Defensins are cationic and amphipathic peptides with six cysteine residues connected by three disulfide bonds found in plants, insects, and mammals; they are divided in three families: α-, β-, and θ-defensins...
July 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28726681/a-novel-cylindrical-microwell-featuring-inverted-pyramidal-opening-for-efficient-cell-spheroid-formation-without-cell-loss
#17
Jae Min Cha, HyungDal Park, Eun Kyoung Shin, Ji Hee Sung, Ockchul Kim, Woohyun Jung, Oh Young Bang, Jinseok Kim
Spheroid cultures have been often used to simulate and understand in situ biological occurrences with potential to be further applied to therapeutic approaches, such as cell transplantation. However, traditional lab-scale techniques hardly reached the needed large scale production of cell spheroids, thus limiting their versatility in many biomedical fields. Microscale technologies have rapidly improved in the last decade, and contributed to the large scale production of cell spheroids with high controllability and reproducibility...
July 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28725865/the-science-of-empathy
#18
Helen Riess
Empathy plays a critical interpersonal and societal role, enabling sharing of experiences, needs, and desires between individuals and providing an emotional bridge that promotes pro-social behavior. This capacity requires an exquisite interplay of neural networks and enables us to perceive the emotions of others, resonate with them emotionally and cognitively, to take in the perspective of others, and to distinguish between our own and others' emotions. Studies show empathy declines during medical training...
June 2017: Journal of patient experience
https://www.readbyqxmd.com/read/28725233/g-quadruplex-in-plants-a-ubiquitous-regulatory-element-and-its-biological-relevance
#19
REVIEW
Vikas Yadav, Hemansi, Nayun Kim, Narendra Tuteja, Puja Yadav
G quadruplexes (G4) are higher-order DNA and RNA secondary structures formed by G-rich sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential G4 quadruplex sequences have been identified in G-rich eukaryotic non-telomeric and telomeric genomic regions. Upon function, G4 formation is known to involve in chromatin remodeling, gene regulation and has been associated with genomic instability, genetic diseases and cancer progression. The natural role and biological validation of G4 structures is starting to be explored, and is of particular interest for the therapeutic interventions for human diseases...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28725057/efficient-generation-of-single-domain-antibodies-with-high-affinities-and-enhanced-thermal-stabilities
#20
Naoya Shinozaki, Ryuji Hashimoto, Kiichi Fukui, Susumu Uchiyama
Single domain antibodies (sdAbs), made of natural single variable regions of camelid or cartilaginous fish antibodies, or unpaired variable regions of mouse or human IgGs, are some of the more promising biologic modalities. However, such conventional sdAbs have difficulties of either using unwieldy animals for immunization or having high affinity deficiencies. Herein, we offer a versatile method to generate rabbit variable domain of heavy chain (rVH) derived sdAbs with high affinities (K D values of single digit nM or less) and enhanced thermal stabilities (equal to or even higher than those of camelid derived sdAbs)...
July 19, 2017: Scientific Reports
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