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https://www.readbyqxmd.com/read/28214230/synthesis-and-cytotoxic-activities-of-goniothalamins-and-derivatives
#1
Anja Weber, Katja Döhl, Julia Sachs, Anja C M Nordschild, Dennis Schröder, Andrea Kulik, Thomas Fischer, Lutz Schmitt, Nicole Teusch, Jörg Pietruszka
Substituted goniothalamins containing cyclopropane-groups were efficiently prepared in high yields and good selectivity. Antiproliferative activity was measured on three human cancer cell lines (A549, MCF-7, HBL-100), to show which of the structural elements of goniothalamins is mandatory for cytotoxicity. We found that the configuration of the stereogenic centre of the δ-lactone plays an important role for cytotoxicity. In our studies only (R)-configured goniothalamins showed antiproliferative activity, whereby (R)-configuration accords to natural goniothalamin (R)-1...
February 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28213537/ketoacylsynthase-domains-of-a-pufa-synthase-in-thraustochytrium-can-effectively-function-as-stand-alone-enzymes-in-escherichia-coli
#2
Xi Xie, Dauenpen Meesapyodsuk, Xiao Qiu
Thraustochytrium sp. 26185 accumulates a high level of docosahexaenoic acid (DHA), a nutritionally important ω-3 very long chain unsaturated fatty acid (VLCPUFA) synthesized primarily by polyunsaturated fatty acid (PUFA) synthase, a Type I polyketide synthase-like mega-enzyme. The PUFA synthase in this species comprises three large subunits each with multiple catalytic domains. It was hypothesized that among these domains, ketoacylsynthase (KS) domains might be critical for catalyzing the condensation of specific unsaturated acyl-ACPs with malonyl-ACP, whereby retaining double bonds in an extended acyl chain...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28212347/molecularly-imprinted-sol-gel-based-qcm-sensor-arrays-for-the-detection-and-recognition-of-volatile-aldehydes
#3
Chuanjun Liu, Bartosz Wyszynski, Rui Yatabe, Kenshi Hayashi, Kiyoshi Toko
The detection and recognition of metabolically derived aldehydes, which have been identified as important products of oxidative stress and biomarkers of cancers; are considered as an effective approach for early cancer detection as well as health status monitoring. Quartz crystal microbalance (QCM) sensor arrays based on molecularly imprinted sol-gel (MISG) materials were developed in this work for highly sensitive detection and highly selective recognition of typical aldehyde vapors including hexanal (HAL); nonanal (NAL) and bezaldehyde (BAL)...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212011/a-fluorescent-anionic-mof-with-zn4-trz-2-chain-for-highly-selective-visual-sensing-of-contaminants-cr-iii-ion-and-tnp
#4
Xiao-Xia Jia, Ru-Xin Yao, Fu-Qiang Zhang, Xian-Ming Zhang
Heavy-metal ions and nitroaromatic substances are highly toxic and harmful to human health and the ecological environment. It is an urgent issue to selectively detect and capture these toxic substances. By introducing the triazole ligand to the π-conjugated aromatic carboxylate system and borrowing the organic template open framework idea, a stable fluorescent framework [Me2NH2]4[Zn6(qptc)3(trz)4]·6H2O (1) (H4qptc = terphenyl-2,5,2'5'-tetracarboxylic acid, trz = 1,2,4-triazole) has been successfully synthesized, which features Zn4(trz)2 chain-based 3D anionic structure with channels filled by [Me2NH2](+) cations...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28210443/evaluation-of-the-effect-of-adding-micro-hydroxyapatite-and-nano-hydroxyapatite-on-the-microleakage-of-conventional-and-resin-modified-glass-ionomer-cl-v-restorations
#5
Farahnaz Sharafeddin, Negar Feizi
BACKGROUND: Pulpal reaction to restorative materials depends on marginal microleakage, which is a dynamic phenomenon that allows bacteria and fluids to traverse across the tooth-restoration interface. Glass-ionomer cement (GIC) exhibits low microleakage due to direct bonding to tooth structures. Hydroxyapatite (HAP) based on the similarity with tooth structure may decrease the microleakage. The aim of this in vitro study was to evaluate marginal microleakage of a mixture of conventional and resin-modified glass-ionomer (RMGI) with micro- and nano-HAP...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210442/a-portable-fiber-optic-raman-spectrometer-concept-for-evaluation-of-mineral-content-within-enamel-tissue
#6
Anna Akkus, Shan Yang, Renato Roperto, Hathem Mustafa, Sorin Teich, Ozan Akkus
BACKGROUND: Measurement of tooth enamel mineralization using a clinically viable method is essential since variation of mineralization may be used to monitor caries risk or in assessing the effectiveness of remineralization therapy. Fiber optic Raman systems are becoming more affordable and popular in context of biomedical applications. However, the applicability of fiber optic Raman systems for measurement of mineral content within enamel tissue has not been elucidated significantly in the prior literature...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210433/effect-of-adhesive-layers-on-microshear-bond-strength-of-nanocomposite-resin-to-dentin
#7
Nayef H Felemban, Mohamed I Ebrahim
BACKGROUND: Bond strength of adhesive layer can absorb unwanted stresses of polymerization shrinkage in composite resin restorations; increased microshear bond strength can prevent failure of restoration materials, the purpose of this study was to evaluate the effect of adhesive layers on microshear bond strength of nanocomposite resin to dentin. MATERIAL AND METHODS: Two different types of adhesive systems: universal adhesive (ExciTE) and newly developed adhesive (Nano-Bond), and one type of light-cured resin restorative material (Nanocomposite resin) were used in this study...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209008/effect-of-resin-bonded-luting-agents-influencing-marginal-discrepancy-in-all-ceramic-complete-veneer-crowns
#8
Dhanraj Ganapathy, Anusha Sathyamoorthy, Hemalatha Ranganathan, Karthikeyan Murthykumar
INTRODUCTION: Marginal discrepancy severely affects the long term success of All ceramic complete veneer crowns. The precise role of resin luting agents influencing this phenomenon needs to be explored further. AIM: To estimate and compare the marginal discrepancy in CAD/CAM processed All ceramic complete veneer crowns prior and following luting with resin bonded luting agents. MATERIALS AND METHODS: Extracted human maxillary first premolars were randomly allocated into four groups of 27 samples each Viz...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205583/flavichalasines-a-m-cytochalasan-alkaloids-from-aspergillus-flavipes
#9
Guangzheng Wei, Dongdong Tan, Chunmei Chen, Qingyi Tong, Xiao-Nian Li, Jinfeng Huang, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo, Hucheng Zhu, Yonghui Zhang
Two new tetracyclic cytochalasans, flavichalasines A and B (1 and 2), three new pentacyclic cytochalasans, flavichalasines C-E (3-5), and eight new tricyclic cytochalasans, flavichalasines F-M (6-13), together with eight known analogues (14-21), were isolated from the solid culture of Aspergillus flavipes. Structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses including 1D, 2D NMR and HRESIMS data. Their absolute configurations were determined by comparison of their experimental ECD with either computed ECD or experimental ECD spectrum of known compound...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203014/-influence-of-surface-treatment-with-sodium-hypochlorite-solution-on-dentin-bond-strength
#10
Y Wang, Y H Liang
OBJECTIVE: To evaluate the influence of sodium hypochlorite (NaOCl) solution used during root canal therapy on dentin bond strength. METHODS: In the study, 15 freshly extracted human third molars with complete dental crowns, caries and filling-free were selected. The occlusal enamel was removed perpendicular to the long axis of the tooth to expose middle flat surfaces of sound dentin. The occlusal dentin surfaces were then polished using 600-grit silicon papers for 1 min and rinsed with deionized water for 1 min...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28203013/-curing-mode-of-universal-adhesives-affects-the-bond-strength-of-resin-cements-to-dentin
#11
Z R Fu, F C Tian, L Zhang, B Han, X Y Wang
OBJECTIVE: To determine the effects of curing mode of one-step and two-step universal adhesives on the micro-tensile bond strength (μTBS) of different dual-cure resin cements to dentin. METHODS: One-step universal adhesive Single Bond Universal (SBU), and two-step universal adhesive OptiBond Versa (VSA) were chosen as the subjects, one-step self-etching adhesive OptiBond All in One (AIO) and two-step self-etching adhesive Clearfil SE Bond (SEB) were control groups, and two dual-cure resin cements RelyX Ultimate (RLX) and Nexus 3 Universal (NX3) were used in this study...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199095/interrelationship-among-the-fe-his-bond-strengths-oxygen-affinities-and-intersubunit-hydrogen-bonding-changes-upon-ligand-binding-in-%C3%AE-subunit-of-human-hemoglobin-the-alkaline-bohr-effect
#12
Shigenori Nagatomo, Miki Okumura, Kazuya Saito, Takashi Ogura, Teizo Kitagawa, Masako Nagai
Regulation of oxygen affinity of human adult hemoglobin (Hb A) at high pH, known as the alkaline Bohr effect, is essential to its physiological function. In this study structural mechanisms of the alkaline Bohr effect and pH-dependent O2 affinity changes are investigated with (1)H NMR, and visible- and UV-resonance Raman spectra of mutant Hbs, Hb M Iwate (αH87Y) and Hb M Boston (αH58Y). It was found that even though the O2 binding to the α subunits is forbidden in the mutant Hbs, the O2 affinity became higher at alkaline pH than at neutral pH and concomitantly, the Fe-His stretching frequency of the β subunits was shifted to higher values...
February 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28198625/curcumin-attenuates-n-nitrosodiethylamine-induced-liver-injury-in-mice-by-utilizing-the-method-of-metabonomics
#13
Peiyu Qiu, Jiachen Sun, Shuli Man, He Yang, Long Ma, Peng Yu, Wenyuan Gao
N-Nitrosodiethylamine (DEN) as one of food additives existed in cheddar cheese, processed meats, beer, water and so forth. It possessed a potent hepatocarcinogen in animals and humans. Curcumin as a natural dietary compound decreased DEN-induced hepatocarcinogenesis in this research. According to the histopathological examination macroof liver tissues, and biomarker detection in serum and livers, it demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level and COX-2/PGE2 pathway...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28198433/a-cyclometalated-iridium-iii-complex-used-as-a-conductor-for-the-electrochemical-sensing-of-ifn-%C3%AE
#14
Xiangmin Miao, Chung-Nga Ko, Kasipandi Vellaisamy, Zongbing Li, Guanjun Yang, Chung-Hang Leung, Dik-Lung Ma
A novel iridium(III) complex was prepared and used as a conductor for sensitive and enzyme-free electrochemical detection of interferon gamma (IFN-γ). This assay is based on a dual signal amplification mechanism involving positively charged gold nanoparticles ((+)AuNPs) and hybridization chain reaction (HCR). To construct the sensor, nafion (Nf) and (+)AuNPs composite membrane was first immobilized onto the electrode surface. Subsequently, a loop-stem structured capture probe (CP) containing a special IFN-γ interact strand was modified onto the (+)AuNP surface via the formation of Au-S bonds...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196881/engineered-holocytochrome-c-synthases-that-biosynthesize-new-cytochromes-c
#15
Deanna L Mendez, Shalon E Babbitt, Jeremy D King, John D'Alessandro, Michael B Watson, Robert E Blankenship, Liviu M Mirica, Robert G Kranz
Cytochrome c (cyt c), required for electron transport in mitochondria, possesses a covalently attached heme cofactor. Attachment is catalyzed by holocytochrome c synthase (HCCS), leading to two thioether bonds between heme and a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to heme iron and upon release of holocytochrome c from HCCS, folding leads to formation of a second axial interaction with methionine (Met81). We previously discovered mutations in human HCCS that facilitate increased biosynthesis of cyt c in recombinant Escherichia coli Focusing on HCCS E159A, novel cyt c variants in quantities that are sufficient for biophysical analysis are biosynthesized...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28195317/human-papillomavirus-self-sampling-for-screening-non-attenders-opt-in-pilot-implementation-with-electronic-communication-platforms
#16
Janni Uyen Hoa Lam, Matejka Rebolj, Ditte Møller Ejegod, Helle Pedersen, Carsten Rygaard, Elsebeth Lynge, Louise Thirstrup Thomsen, Susanne Krüger Kjaer, Jesper Bonde
In organized cervical screening programs, typically 25% of the invited women do not attend. The Copenhagen Self-sampling Initiative (CSi) aimed to gain experiences on participation among screening non-attenders in the Capital Region of Denmark. Here, we report on the effectiveness of different communication platforms used in the pilot with suggestions for strategies prior to a full-implementation. Moreover, an innovative approach using self-sampling brushes with unique radio frequency identification chips allowed for unprecedented levels patient identification safety...
February 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28195277/dentin-bonding-durability-of-two-step-self-etch-adhesives-with-improved-of-degree-of-conversion-of-adhesive-resins
#17
Kento Sato, Keiichi Hosaka, Masahiro Takahashi, Masaomi Ikeda, Fucong Tian, Wataru Komada, Masatoshi Nakajima, Richard Foxton, Yoshihiro Nishitani, David H Pashley, Junji Tagami
PURPOSE: To evaluate (1) the initial and long-term microtensile bond strengths of two-step self-etch adhesives with different degrees of conversion (DC); (2) the elastic modulus of the respective adhesive resins; (3) the water sorption of the respective adhesive resins. MATERIALS AND METHODS: Two two-step self-etch adhesives, Clearfil SE Bond (CSE) and Clearfil SE Bond 2 (CSE2) were used in this study. The DC was determined using ATR/FT-IR with a time-based spectrum analysis...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28193868/dopamine-in-the-medial-amygdala-network-mediates-human-bonding
#18
Shir Atzil, Alexandra Touroutoglou, Tali Rudy, Stephanie Salcedo, Ruth Feldman, Jacob M Hooker, Bradford C Dickerson, Ciprian Catana, Lisa Feldman Barrett
Research in humans and nonhuman animals indicates that social affiliation, and particularly maternal bonding, depends on reward circuitry. Although numerous mechanistic studies in rodents demonstrated that maternal bonding depends on striatal dopamine transmission, the neurochemistry supporting maternal behavior in humans has not been described so far. In this study, we tested the role of central dopamine in human bonding. We applied a combined functional MRI-PET scanner to simultaneously probe mothers' dopamine responses to their infants and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial prefrontal cortex (mPFC), which form an intrinsic network (referred to as the "medial amygdala network") that supports social functioning...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28192979/structural-characterization-of-native-proteins-and-protein-complexes-by-electron-ionization-dissociation-mass-spectrometry
#19
Huilin Li, Yuewei Sheng, William M McGee, Michael Cammarata, Dustin D Holden, Joseph A Loo
Mass spectrometry (MS) has played an increasingly important role in the identification and structural and functional characterization of proteins. In particular, the use of tandem mass spectrometry has afforded one of the most versatile methods to acquire structural information for proteins and protein complexes. The unique nature of electron capture dissociation (ECD) for cleaving protein backbone bonds while preserving non-covalent interactions has made it especially suitable for the study of native protein structures...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192709/tetrazolylmethyl-quinolines-design-docking-studies-synthesis-anticancer-and-antifungal-analyses
#20
Saba Kauser J Shaikh, Ravindra R Kamble, Shilpa M Somagond, H C Devarajegowda, Sheshagiri R Dixit, Shrinivas D Joshi
A new series of 2,5 and 1,5-regioisomers of the tetrazolyl group viz., 3-[(5-benzyl/benzylthio-2H-tetrazol-2-yl) methyl]-2-chloro-6-substituted quinoline 6h-q and 3-[(5-benzyl/benzylthio-1H-tetrazol-1-yl) methyl]-2-chloro-6-substituted quinolines 7h-q were synthesized. Docking studies of all these compounds with DNA as target using PDB: 1AU5 and 453D revealed that the compounds 6h and 6i act as covalent cross linker on the DNA helix of the former and intercalate the latter both with higher C score values. Another set of docking studies in the active pocket of dihydrofolate reductase and N-myristoyl transferase as targets to assess antifungal activity revealed that compounds 6k, 6l, 6p and 7q (with bromo and fluro substituents) showcases different binding modes and hydrogen bonding...
February 1, 2017: European Journal of Medicinal Chemistry
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