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https://www.readbyqxmd.com/read/29786637/dog-theft-a-case-for-tougher-sentencing-legislation
#1
REVIEW
Lauren K Harris
Dogs, and other companion animals, are currently classed as "property" in theft sentencing legislation for England and Wales. This means that offenders who steal dogs are given similar sentences to those that steal inanimate objects. This review presents the argument that the penalty for dog theft should be more severe than for the theft of non-living property. Evidence of the unique bond between dogs and humans, and discussion of the implications of labelling a living being as mere "property" are used to support this argument...
May 22, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29784829/short-chain-dehydrogenase-reductase-governs-steroidal-specialized-metabolites-structural-diversity-and-toxicity-in-the-genus-solanum
#2
Prashant D Sonawane, Uwe Heinig, Sayantan Panda, Netta Segal Gilboa, Meital Yona, S Pradeep Kumar, Noam Alkan, Tamar Unger, Samuel Bocobza, Margarita Pliner, Sergey Malitsky, Maria Tkachev, Sagit Meir, Ilana Rogachev, Asaph Aharoni
Thousands of specialized, steroidal metabolites are found in a wide spectrum of plants. These include the steroidal glycoalkaloids (SGAs), produced primarily by most species of the genus Solanum , and metabolites belonging to the steroidal saponins class that are widespread throughout the plant kingdom. SGAs play a protective role in plants and have potent activity in mammals, including antinutritional effects in humans. The presence or absence of the double bond at the C-5,6 position (unsaturated and saturated, respectively) creates vast structural diversity within this metabolite class and determines the degree of SGA toxicity...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784645/harnessing-post-translational-modifications-for-next-generation-hiv-immunogens
#3
REVIEW
Joel D Allen, Rogier W Sanders, Katie J Doores, Max Crispin
The extensive post-translational modifications of the envelope spikes of the human immunodeficiency virus (HIV) present considerable challenges and opportunities for HIV vaccine design. These oligomeric glycoproteins typically have over 30 disulfide bonds and around a 100 N-linked glycosylation sites, and are functionally dependent on protease cleavage within the secretory system. The resulting mature structure adopts a compact fold with the vast majority of its surface obscured by a protective shield of glycans which can be targeted by broadly neutralizing antibodies (bnAbs)...
May 21, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29781759/development-of-simultaneous-quantification-method-of-loteprednol-etabonate-le-and-its-acidic-metabolites-and-analysis-of-le-metabolism-in-rat
#4
Ahmed Samir, Ayano Kage, Ohura Kayoko, Teruko Imai
1. Loteprednol etabonate (LE) is a soft corticosteroid with two labile ester bonds at 17α- and 17β-positions. Its corticosteroidal activity disappears upon hydrolysis of either ester bond. Hydrolysis of both ester bonds produces the inactive metabolite, Δ1 -cortienic acid (Δ1 -CA). 2. The simple high performance liquid chromatography method using acetic acid gradient was developed for the simultaneous determination of LE and its acidic metabolites. 3. LE was hydrolyzed in rat plasma with a half-life of 9 minutes...
May 21, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29780533/a-halogen-bond-mediated-highly-active-artificial-chloride-channel-with-high-anticancer-activity
#5
Changliang Ren, Xin Ding, Arundhati Roy, Jie Shen, Shaoyuan Zhou, Feng Chen, Sam Fong Yau Li, Haisheng Ren, Yi Yan Yang, Huaqiang Zeng
Chloride-selective transmembrane carriers or channels might have possible uses in treating channelopathies or cancers. While chloride carriers have been extensively investigated, the corresponding chloride channels have remained limitedly studied. Moreover, all hitherto reported channel systems lack clearly definable and readily modifiable positions in their structures for the reliable construction and combinatorial optimization of their ion transport properties. As a result, the existing channels are limited by their large molecular weight, weak activity or low anion selectivity...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780246/remineralization-potential-of-nano-hydroxyapatite-on-enamel-and-cementum-surrounding-margin-of-computer-aided-design-and-computer-aided-manufacturing-ceramic-restoration
#6
Niwut Juntavee, Apa Juntavee, Preeyarat Plongniras
Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento-enamel junction to remove the cemento-enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29779754/introduction-art-and-the-brain-from-pleasure-to-well-being
#7
EDITORIAL
Julia F Christensen, Antoni Gomila
Empirical aesthetics in general, and neuroaesthetics in particular, have been very much influenced by Berlyne's psychobiological program. For him, aesthetic appreciation involved the brain's reward and aversion systems. From this point of view, art constitutes a set of potentially rewarding stimuli. Research has certainly made great advances in understanding how the process of artistic valuation takes places, and which brain circuits are involved in generating the pleasure we obtain from artistic practices, performances, and works...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29779732/music-dance-and-other-art-forms-new-insights-into-the-links-between-hedonia-pleasure-and-eudaimonia-well-being
#8
Eloise A Stark, Peter Vuust, Morten L Kringelbach
For Aristotle, the goal of human life was to live well, to flourish, and to ultimately have a good life. These goals can be conceptualized as "eudaimonia," a concept distinct from "hedonia" (pleasure). Many people would argue that the arts play a large role in their well-being and eudaimonia. Music in particular is a culturally ubiquitous phenomenon which brings joy and social bonding to listeners. Research has given insights into how the "sweet anticipation" of music and other art forms can lead to pleasure, but a full understanding of eudaimonia from the arts is still missing...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29779627/in-vitro-assessment-of-ribose-modified-two-step-etch-and-rinse-dentine-adhesive
#9
U Daood, J K H Tsoi, P Neelakantan, J P Matinlinna, H A K Omar, M Al-Nabulsi, A S Fawzy
OBJECTIVE: Collagen fibrils aid in anchoring resin composite restorations to the dentine substrate. The aim of the study was to investigate effect of non-enzymatic glycation on bond strength and durability of demineralized dentine specimens in a modified two-step etch-and-rinse dentine adhesive. METHODS: Dentine surfaces were etched with 37% phosphoric acid, bonded with respective in vitro ethanol and acetone adhesives modified with (m/m, 0, 1%, 2% and 3% ribose), restored with restorative composite-resin, and sectioned into resin-dentine slabs and beams to be stored for 24h or 12 months in artificial saliva...
May 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29778987/effect-of-ethanol-dissolved-rhodamine-b-marker-on-mechanical-properties-of-non-simplified-adhesives
#10
Camila Moreira Machado, Odair Bim Júnior, Marina Ciccone Giacomini, Márcia Sirlene Zardin Graeff, Fernanda Cristina Pimentel Garcia, Daniela Rios, Heitor Marques Honório, Linda Wang
OBJECTIVES: Rhodamine B (RB) is commonly used to evaluate dental polymers, including dental bonding systems (DBS). For reliability assessments, its effect should not only allow visualization of the dentin-polymer interface but also must not interfere with the bonding of the DBS to dentin as measured by the microtensile bond strength and hardness tests. MATERIAL AND METHODS: Flat human dentin surfaces were prepared and randomly distributed (n = 10) into six groups: Adper Scotchbond Multi-Purpose (MP) or Clearfil SE Bond (SE) in concentrations of none/control, 0...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29777934/specific-stability-indicating-spectrofluorimetric-method-for-determination-of-ledipasvir-in-the-presence-of-its-confirmed-degradation-products-application-in-human-plasma
#11
Ramadan Ali, Adel A Marzouk, Reda A Abdelhameid, Mahmoud A Omar
A rapid and specific spectrofluorimetric method with higher sensitivity was developed for determination of ledipasvir (LDS) in tablets and human plasma. The proposed method relies on hydrogen bonding formations between the hydroxyl groups of polyoxyethylene 50 stearate and LDS, causing significant enhancement of its native fluorescence. The fluorescence intensity was measured at 430 nm after excitation at 340 nm. The fluorescence-concentration plot was rectilinear over the range 1-400 ng mL-1 with detection and quantification limits of 0...
May 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777928/binding-studies-of-triclocarban-with-bovine-serum-albumin-insights-from-multi-spectroscopy-and-molecular-modeling-methods
#12
Jiao Guan, Xin Yan, Yajing Zhao, Yinhe Sun, Xin Peng
The antimicrobial triclocarban (TCC) is frequently found in various personal care products (PCPs), and recent studies have demonstrated that it shows a high unintended biological activity on humans and wildlife. To evaluate the toxicity of TCC at the protein level, the effect of TCC on bovine serum albumin (BSA) has been investigated using various spectroscopic methods in combination with molecular modeling. Analysis of fluorescence quenching data of BSA revealed the formation of a ground state BSA-TCC complex with a binding constant of 2...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777832/novel-cysteine-and-albumin-adduct-biomarkers-to-prove-human-poisoning-with-the-pesticide-oxydemeton-s-methyl
#13
Harald John, Markus Siegert, Florian Eyer, Franz Worek, Horst Thiermann, Andreas Kranawetvogl
We herein report on the forensic analysis of plasma samples to prove human poisoning with oxydemeton-S-methyl (ODM), S-(2-(ethylsulfinyl)ethyl)-O,O-dimethyl phosphorothioate. This organophosphorus pesticide is the active ingredient of Metasystox® , that was swallowed by a 77-year-old woman to commit suicide. ODM belongs to the class of dimethyl phosphoryl (DMP) pesticides, contains a 2-(ethylsulfinyl)ethanethiol (ESOET) leaving group and undergoes adduct formation with endogenous molecules as elaborated herein with human serum exposed to pesticides in vitro...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29777317/using-smiles-strings-for-the-description-of-chemical-connectivity-in-the-crystallography-open-database
#14
Miguel Quirós, Saulius Gražulis, Saulė Girdzijauskaitė, Andrius Merkys, Antanas Vaitkus
Computer descriptions of chemical molecular connectivity are necessary for searching chemical databases and for predicting chemical properties from molecular structure. In this article, the ongoing work to describe the chemical connectivity of entries contained in the Crystallography Open Database (COD) in SMILES format is reported. This collection of SMILES is publicly available for chemical (substructure) search or for any other purpose on an open-access basis, as is the COD itself. The conventions that have been followed for the representation of compounds that do not fit into the valence bond theory are outlined for the most frequently found cases...
May 18, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29775901/tricine-co-ligand-improved-the-efficacy-of-99m-tc-hynic-ser-3-j18-peptide-for-targeting-and-imaging-of-non-small-cell-lung-cancer
#15
Zahra Shaghaghi, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
The early diagnosis of non-small cell lung cancer (NSCLC) is important for increasing survival rate and improving quality life of patients. The aim of this study was to investigate 99m  Tc-(tricine)-HYNIC-(Ser)3 -J18 for targeting and imaging of NSCLC in A-549 xenografted nude mice. The (Ser)3 -J18 peptide was conjugated with HYNIC and labeled with 99m  Tc using tricine as a co-ligand. The radiolabeled peptide was evaluated for its radiochemical purity, stability, receptor binding and internalization in vitro...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775635/enhanced-sampling-of-interdomain-motion-using-map-restrained-langevin-dynamics-and-nmr-application-to-pin1
#16
Jill J Bouchard, Junchao Xia, David A Case, Jeffrey W Peng
Many signaling proteins consist of globular domains connected by flexible linkers that allow for substantial domain motion. Because these domains often serve as complementary functional modules, the possibility of functionally important domain motions arises. To explore this possibility, we require knowledge of the ensemble of protein conformations sampled by interdomain motion. Measurements of NMR residual dipolar couplings (RDCs) of backbone NH bonds offer a per-residue characterization of interdomain dynamics, as the couplings are sensitive to domain orientation...
May 15, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29772456/new-insights-into-the-in-vitro-biological-effects-in-silico-docking-and-chemical-profile-of-clary-sage-salvia-sclarea-l
#17
Gokhan Zengin, Ismail Senkardes, Adriano Mollica, Carene Marie Nancy Picot-Allain, Gizem Bulut, Ahmet Dogan, M Fawzi Mahomoodally
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40...
May 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29772410/estrogenic-properties-of-coumarins-and-meroterpene-from-the-fruits-of-cullen-corylifolium-experimental-and-computational-studies
#18
Tiehua Zhang, Shuning Zhong, Ligang Hou, Tiezhu Li, XiaoJia Xing, Tianzhu Guan, Jie Zhang, Yongjun Wang
Coumarins and meroterpene from the fruits of Cullen corylifolium were evaluated for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro studies and molecular dynamics simulations. The recombinant hERα ligand binding domain (hERα-LBD) was produced in BL21 (DE3)pLysS and the fluorescence polarization (FP) assay was performed to determine the binding affinities of coumarins and meroterpene with receptor protein. These compounds displayed distinct binding potency toward hERα-LBD, generally increased with their increasing molecular length and Connolly solvent-excluded volume (CSEV)...
May 14, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29772211/synthesis-folding-structure-and-activity-of-a-predicted-peptide-from-the-sea-anemone-oulactis-sp-with-an-shkt-fold
#19
Bankala Krishnarjuna, Jessica Villegas-Moreno, Michela L Mitchell, Agota Csoti, Steve Peigneur, Carlos Amero, Michael W Pennington, Jan Tytgat, Gyorgy Panyi, Raymond S Norton
Sea anemone venom is rich in bioactive compounds, including peptides containing multiple disulfide bridges. In a transcriptomic study on Oulactis sp., we identified the putative 36-residue peptide, OspTx2b, which is an isoform of the KV channel blocker OspTx2a (Sunanda P et al. (2018) Identification, chemical synthesis, structure and function of a new KV 1 channel blocking peptide from Oulactis sp. Peptide Science, in press). As OspTx2b contains a ShK/BgK-like cysteine framework, with high amino acid sequence similarity to BgK, we were interested to investigate its structure and function...
May 14, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#20
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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