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https://www.readbyqxmd.com/read/29344192/tslp-promotes-angiogenesis-of-human-umbilical-vein-endothelial-cells-by-strengthening-the-crosstalk-between-cervical-cancer-cells-and-eosinophils
#1
Bing Zhang, Chun-Yan Wei, Kai-Kai Chang, Jia-Jun Yu, Wen-Jie Zhou, Hui-Li Yang, Jun Shao, Jin-Jin Yu, Ming-Qing Li, Feng Xie
Our previous study demonstrated that thymic stromal lymphopoietin (TSLP) secreted by cervical cancer cells promotes angiogenesis and recruitment, and regulates the function of eosinophils (EOS). However, the function of TSLP in the crosstalk between EOS and vascular endothelial cells in cancer lesions remains unknown. The aim of the present study was to investigate the effect of EOS caused by TSLP in in vitro angiogenesis of human umbilical vein endothelial cells (HUVECs). The results of the present study revealed that recombinant human TSLP protein (rhTSLP) increased the secretion of vascular endothelial growth factor (VEGF), but not fibroblast growth factors, in HL-60-eosinophils (HL-60E)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29333007/utility-of-cluster-of-differentiation-5-and-cluster-of-differentiation-117-immunoprofile-in-distinguishing-thymic-carcinoma-from-pulmonary-squamous-cell-carcinoma-a-study-on-1800-nonsmall-cell-lung-cancer-cases
#2
Vidya Jha, Preeti Sharma, Ashish Kumar Mandal
Background: Mediastinum harbors a mixed bag of neoplastic lesions with varied therapeutic and prognostic implications. Distinguishing pulmonary squamous cell carcinoma from thymic carcinoma is a challenging task owing to rather nonspecific clinicoradiological features and a considerable overlap in histomorphological features. Thus, we evaluated the diagnostic utility of cluster of differentiation 5 (CD5) and CD117 immunohistochemical markers in distinguishing these tumors. Materials and Methods: The archives of department of histopathology were retrospectively reviewed from June 2012 to May 2016...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29331646/progress-in-the-management-of-advanced-thoracic-malignancies-in-2017
#3
REVIEW
Roberto Ferrara, Laura Mezquita, Benjamin Besse
The treatment paradigm of non-small cell lung cancer (NSCLC) underwent a major revolution during the course of 2017. Immune checkpoint inhibitors (ICIs) brought remarkable improvements in response and overall survival (OS) both in unselected pretreated patients and in untreated patients with PD-L1 expression ≥50%. Furthermore, compelling preliminary results were reported for new combinations of anti-PD-1/PD-L1 agents with chemotherapy or anti-CTLA4 inhibitors. The success of the ICIs appeared to extend to patients with small cell lung cancer (SCLC), mesothelioma or thymic tumors...
January 10, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29321954/a-role-for-caspase-2-in-sphingosine-kinase-1-proteolysis-in-response-to-doxorubicin-in-breast-cancer-cells-implications-for-the-chk1-suppressed-pathway
#4
Brittany L Carroll, Joseph Bonica, Achraf A Shamseddine, Yusuf A Hannun, Lina M Obeid
Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1-phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstream of the tumor suppressor p53 in response to several DNA-damaging agents. Moreover, loss of SK1 in p53-knockout mice resulted in complete protection from thymic lymphoma, providing evidence that regulation of SK1 constitutes a major tumor suppressor function of p53...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29250181/human-thymic-stromal-lymphopoietin-promotes-the-proliferation-and-invasion-of-cervical-cancer-cells-by-downregulating-microrna-132-expression
#5
Wen-Jie Zhou, Hui-Li Yang, Kai-Kai Chang, Yi Meng, Ming-Yan Wang, Min-Min Yuan, Ming-Qing Li, Feng Xie
Thymic stromal lymphopoietin (TSLP), produced by cervical cancer (CC) cells, promotes angiogenesis, and the recruitment and functional regulation of eosinophils. It has been reported that microRNA (miR)-132 is aberrantly decreased in CC tissues. However, the function and mechanism of TSLP on the biological behaviors of CC cells is largely unknown. The aim of the present study was to investigate the effect of TSLP on the expression of miR-132 and the proliferation and invasion in vitro of CC cell lines, namely, HeLa and SiHa cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29233791/incidental-anterior-mediastinal-nodular-lesions-on-chest-ct-in-asymptomatic-subjects
#6
Soon Ho Yoon, Seung Ho Choi, Chang Hyun Kang, Jin Mo Goo
HYPOTHESIS: To investigate the prevalence and characteristics of nodular lesions in the anterior mediastinum that had been incidentally found on screening chest CT in asymptomatic subjects. METHODS: We included 56,358 consecutive participants (mean age, 52.4±10.5 years; male-female, 35,306:21,052) who underwent a baseline low-dose chest CT scan for health checkups from 2006 through 2013. After confirming the presence of anterior mediastinal nodular lesion, their CT findings, confirmatory diagnosis and interval CT scan were reviewed...
December 9, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29223525/case-series-of-rare-thymoma-metastases-to-the-spine-and-complete-literature-review
#7
Rebecca L Achey, Bryan S Lee, Swetha Sundar, Edward C Benzel, Ajit A Krishnaney
BACKGROUND: We report a series of three cases of metastatic thymoma to the spine with spinal cord compression. An extensive literature review of thymic metastases to the spine was completed in order to provide a comprehensive appraisal of current prognostic indicators and potential treatment algorithms to help guide clinicians in treatment management. CASE DESCRIPTIONS: Between 2000 and 2017, three patients were diagnosed with thymic metastases to the spine at our institution...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29219888/computed-tomography-features-associated-with-the-eighth-edition-tnm-stage-classification-for-thymic-epithelial-tumors
#8
Sukhmani K Padda, Donato Terrone, Lu Tian, Amanda Khuong, Joel W Neal, Jonathan W Riess, Mark F Berry, Chuong D Hoang, Bryan M Burt, Ann N Leung, Erich J Schwartz, Joseph B Shrager, Heather A Wakelee
PURPOSE: The eighth edition of the TNM classification of malignant tumors for the first time includes an official staging system for thymic epithelial tumors (TETs) recognized by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). Staging is critical for the management of TETs, and determining stage accurately from imaging has the potential to improve clinical outcomes. We examine preoperative computed tomography (CT) characteristics of TETs associated with AJCC/UICC pathologic TNM stage...
December 6, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29201452/neuroendocrine-tumors-of-the-thymus-the-oncologist-point-of-view
#9
REVIEW
Nicolas Girard
Thymic malignancies represent a heterogeneous group of rare thoracic cancers, which are classified according to the World Health Organization (WHO) histopathologic classification that distinguishes thymomas from thymic carcinomas and neuroendocrine tumors; neuroendocrine thymic tumors (NETTs) exhibit the same histological spectrum as in other anatomical locations, although with different frequencies. NETTs represent around 2% of all neuroendocrine tumors, and about 5% of all thymic malignancies. Overall, the management of patients with NETTs tumors requires continuous multidisciplinary expertise at any step of the disease progression...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29197400/evaluation-of-the-new-tnm-staging-system-for-thymic-malignancies-impact-on-indication-and-survival
#10
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Zsolt Sziklavari, Hans-Stefan Hofmann
BACKGROUND: The objective of this study is the evaluation of the Masaoka-Koga and the International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancy Interest Group (ITMIG) proposal for the new TNM-staging system on clinical implementation and prognosis of thymic malignancies. METHODS: A retrospective study of 76 patients who underwent surgery between January 2005 and December 2015 for thymoma. Kaplan-Meier survival analysis was used to determine overall and recurrence-free survival rates...
December 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29193236/inhibitory-effect-of-naringenin-via-il-13-level-regulation-on-thymic-stromal-lymphopoietin-induced-inflammatory-reactions
#11
Na-Ra Han, Phil-Dong Moon, Ka-Jung Ryu, Na-Rae Kim, Hyung-Min Kim, Hyun-Ja Jeong
Naringenin (NG) has various beneficial properties, such as anti-cancer and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) induces mast cell proliferation and inflammatory reactions. The aim of this study was to investigate the regulatory effect of NG on TSLP-induced mast cell proliferation and inflammatory reactions using human mast cell line (HMC-1) cells. HMC-1 cells were pre-treated with NG and then treated with TSLP. HMC-1 cells proliferation was determined by quantifying bromodeoxyuridine incorporation...
November 29, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29187357/iap-antagonists-enhance-cytokine-production-from-mouse-and-human-inkt-cells
#12
Eleanor Clancy-Thompson, Lestat Ali, Patrick T Bruck, Mark A Exley, Richard S Blumberg, Glenn Dranoff, Michael Dougan, Stephanie K Dougan
Inhibitor of apoptosis protein (IAP) antagonists are in clinical trials for a variety of cancers, and mouse models show synergism between IAP antagonists and anti-PD-1 immunotherapy. Although IAP antagonists affect the intrinsic signaling of tumor cells, their most pronounced effects are on immune cells and the generation of antitumor immunity. Here we examined the effects of IAP antagonism on T-cell development using mouse fetal thymic organ culture and observed a selective loss of iNKT cells, an effector cell type of potential importance for cancer immunotherapy...
November 29, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29177878/anterior-mediastinal-lymph-nodes-in-chemically-induced-breast-cancer
#13
O V Kazakov, A V Kabakov, A F Poveshchenko, T V Raiter, D N Strunkin, I Yu Ishchenko, A P Lykov, S V Michurina, V I Konenkov
The anterior mediastinal lymph nodes were analyzed morphometrically in rats with chemically provoked breast cancer. Rats with untreated breast cancer and animals receiving chemotherapy demonstrated decreased volumes of paracortical region and lymphoid nodules with the germinal centers accompanied by extended medullary thymic substance. Resection of largest focus of breast tumor improved the filtration barrier potential of anterior mediastinal lymph nodes, up-regulated the proliferative activity of lymphoid cells in T-cell zones, and down-regulated proliferation of plasmatic cells...
December 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29163553/ppargamma-deficiency-counteracts-thymic-senescence
#14
David Ernszt, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M Lord, Judit E Pongracz, Krisztian Kvell
Thymic senescence contributes to increased incidence of infection, cancer and autoimmunity at senior ages. This process manifests as adipose involution. As with other adipose tissues, thymic adipose involution is also controlled by PPARgamma. This is supported by observations reporting that systemic PPARgamma activation accelerates thymic adipose involution. Therefore, we hypothesized that decreased PPARgamma activity could prevent thymic adipose involution, although it may trigger metabolic adverse effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162511/the-thymidylate-synthase-enhancer-region-tser-polymorphism-increases-the-risk-of-thymic-lymphoid-hyperplasia-in-patients-with-myasthenia-gravis
#15
Angela Lopomo, Roberta Ricciardi, Anna De Rosa, Melania Guida, Michelangelo Maestri, Marco Lucchi, Franca Melfi, Alfredo Mussi, Lucia Migliore, Fabio Coppedè
BACKGROUND: Myasthenia Gravis (MG) is caused, in approximately 80% of the patients, by autoantibodies against the nicotinic acetylcholine receptor (AChR). The disease is often associated with pathological changes of the thymus: thymic epithelial tumours are present in about 10-20% of the patients, while up to 80% of the patients with early disease onset have thymic hyperplasia. Folate metabolism is required for the production of DNA precursors and for proper DNA methylation reactions, and impaired folate metabolism has been often associated with cellular growth and cancer...
November 18, 2017: Gene
https://www.readbyqxmd.com/read/29147447/rare-case-of-spinal-cord-compression-as-initial-presentation-of-thymic-carcinoma
#16
Prabhsimranjot Singh, Ankur Sinha, Sonali Malhotra, Abhinav Binod Chandra, William Solomon, Yiwu Huang
Thymic carcinomas are rare aggressive cancers with limited clinical trial data. Its usual treatment is surgical resection with variable response to chemotherapy and radiation. It usually presents as anterior mediastinal mass with late sequela of metastases to the lymph nodes, pleura and bones. We present of thymic carcinoma with a rare initial presentation of vertebral metastases causing spinal cord compression.
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146413/ct-fluoroscopy-guided-core-needle-biopsy-of-anterior-mediastinal-masses
#17
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, J Sakurai, Y Masaoka, M Uka, T Tanaka, H Gobara, S Kanazawa
OBJECTIVE: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. MATERIALS AND METHODS: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [±standard deviation] age, 53.8±20.0years; range, 14-88years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings...
November 13, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29120527/castle-tumor-of-the-parotid-first-documented-case-literature-review-and-genetic-analysis-of-the-cancer
#18
Eugene Hung Chih Wong, Nora Tetter, Alexandar Tzankov, Laurent Muller
BACKGROUND: Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy. METHOD: A 55-year-old woman presented with a slow-growing right parotid mass...
November 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/29116372/tumor-derived-high-mobility-group-box-1-and-thymic-stromal-lymphopoietin-are-involved-in-modulating-dendritic-cells-to-activate-t-regulatory-cells-in-a-mouse-model
#19
Yi Zhang, Zuqiang Liu, Xingxing Hao, Ang Li, Jiying Zhang, Cara D Carey, Louis D Falo, Zhaoyang You
High-mobility group box 1 (HMGB1) is involved in the tumor-associated activation of regulatory T cells (Treg), but the mechanisms remain unknown. In a mouse tumor model, silencing HMGB1 in tumor cells or inhibiting tumor-derived HMGB1 not only dampened the capacity of tumor cells to produce thymic stromal lymphopoietin (TSLP), but also aborted the tumor-associated modulation of Treg-activating DC. Tumor-derived HMGB1 triggered the production of TSLP by tumor cells. Importantly, both tumor-derived HMGB1 and TSLP were necessary for modulating DC to activate Treg in a TSLP receptor (TSLPR)-dependent manner...
November 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29114386/suppression-of-inflammation-and-tissue-damage-by-a-hookworm-recombinant-protein-in-experimental-colitis
#20
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
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