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https://www.readbyqxmd.com/read/28400429/genomic-analysis-of-thymic-epithelial-tumors-identifies-novel-subtypes-associated-with-distinct-clinical-features
#1
Hyun-Sung Lee, Hee-Jin Jang, Rohan Shah, David Yoon, Masatsugu Hamaji, Ori Wald, Ju-Seog Lee, David J Sugarbaker, Bryan M Burt
PURPOSE To reconcile the heterogeneity of thymic epithelial tumors (TETs) and gain deeper understanding of the molecular determinants of TETs, we set out to establish a clinically relevant molecular classification system for these tumors. <p>EXPERIMENTAL DESIGN Molecular subgrouping of TETs was performed in 120 patients from The Cancer Genome Atlas using a multidimensional approach incorporating analyses of DNA mutations, mRNA expression, and somatic copy number alterations (SCNA), and validated in two independent cohorts...
April 11, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28386277/thyroid-related-protein-expression-in-the-human-thymus
#2
Mi Jeong Kim, So Won Oh, Hyewon Youn, Juri Na, Keon Wook Kang, Do Joon Park, Young Joo Park, Ja June Jang, Kyu Eun Lee, Kyeong Cheon Jung, June-Key Chung
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer. However, the normal thymic uptake of radioiodine has occasionally been observed in young patients. We evaluated the expression of thyroid-related genes and proteins in the human thymus. Thymic tissues were obtained from 22 patients with thyroid cancer patients of all ages. The expression of NIS, thyroid-stimulating hormone receptor (TSHR), thyroperoxidase (TPO), and thyroglobulin (Tg) was investigated using immunohistochemistry and quantitative RT-PCR...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28367393/thymic-carcinoma-treated-by-cyberknife-stereotactic-body-radiotherapy
#3
Yuko Harada, Shinichiro Miyazaki
The standard treatment for advanced thymic carcinoma has not yet been established. Most patients have no symptoms until the advanced stage. Radiation therapy has been used for advanced stage cancer, usually in combination with surgery or chemotherapy; however, the survival rates are 30%-50%. We performed hypofractionated stereotactic radiotherapy with CyberKnife (Accuray, Sunnyvale, CA, USA) for 10 cases of advanced thymic cancer. All cases reached at least partial remission (PR) in two months with progression-free irradiated lesions and minimal radiation-related toxicity...
February 26, 2017: Curēus
https://www.readbyqxmd.com/read/28347273/stage-ivb-thymic-carcinoma-patients-with-lymph-node-metastases-have-better-prognoses-than-those-with-hematogenous-metastases
#4
Yu Yang, Xing-Wen Fan, Hong-Bing Wang, Yin Xu, Dou-Dou Li, Kai-Liang Wu
BACKGROUND: This study aimed to analyze the pattern of lymphogenous and hematogenous metastases in patients with stage IVb thymic carcinomas and identify prognostic factors for their survivals. METHODS: Between September 1978 and October 2014, 68 patients with pathologically confirmed stage IVb thymic carcinomas were treated at Fudan University Shanghai Cancer Center. Forty-three patients had lymph node involvement without distant metastases, and the remaining 25 patients had hematogenous metastases...
March 27, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28336378/optimized-biodegradable-polymeric-reservoir-mediated-local-and-sustained-co-delivery-of-dendritic-cells-and-oncolytic-adenovirus-co-expressing-il-12-and-gm-csf-for-cancer-immunotherapy
#5
Eonju Oh, Jung-Eun Oh, JinWoo Hong, YoonHo Chung, Yunki Lee, Ki Dong Park, Sungwan Kim, Chae-Ok Yun
Administration of dendritic cells (DCs) combined with oncolytic adenovirus (Ad) expressing antitumor cytokines induces a potent antitumor effect and antitumor immunity by ameliorating the immunosuppressive tumor microenvironment. However, this combination therapy has significant limitations due to rapid dissemination and inactivation of the therapeutics at the tumor site, necessitating multiple injections of both therapeutics. To overcome these limitations, we have utilized gelatin-based hydrogel to co-deliver oncolytic Ad co-expressing interleukin (IL)-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF) (oAd) and DCs for sustained release of both therapeutics...
March 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28323731/thymic-carcinoma-with-endobronchial-metastasis-a-case-report
#6
Makoto Nagamata, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima
Thymic carcinoma is a rare cancer, accounting for only 1% to 4% of thymic epithelial tumors. Endobronchial metastasis is a rare presentation of these tumors. A 64-year-old man presented with a cough. Lung cancer was suspected because a chest radiograph showed a 7-cm mass in the left pulmonary hilum. Computed tomography showed a mass in the anterior mediastinum and an infiltrate in the upper lobe of the left lung. Bronchoscopy demonstrated bilateral polypoid tumors in the left B bronchus and the right B bronchus...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28285814/thymic-determinants-of-%C3%AE-%C3%AE-t-cell-differentiation
#7
REVIEW
Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J Pennington, Bruno Silva-Santos
γd T cells have emerged as major sources of the proinflammatory cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ) in multiple models of infection, cancer and autoimmune disease. However, unlike their αβ T cell counterparts that require peripheral activation for effector cell differentiation, γδ T cells instead can be 'developmentally programmed' in the thymus to generate discrete γδ T cell effector subsets with distinctive molecular signatures. Nonetheless, recent studies have presented conflicting viewpoints on the signals involved in thymic γδ T cell development and differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent factors...
March 9, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28275684/thymic-stromal-lymphopoietin-to-cut-a-long-story-short
#8
REVIEW
Katerina Tsilingiri, Giulia Fornasa, Maria Rescigno
Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified. The signaling pathway triggered by TSLP has been extensively studied, and upregulation of the cytokine itself is linked to the pathogenesis of numerous Th2-related diseases, including atopic dermatitis, asthma, allergic responses, as well as certain types of cancers. On the other hand, TSLP mediates several immune homeostatic functions in both the gut and the thymus...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28261208/t-cell-subpopulations-in-healthy-elderly-and-lung-cancer-patients-insights-from-cuban-studies
#9
REVIEW
Danay Saavedra, Beatriz Garcia, Agustin Lage
The senescence of the immune system and the risk of cancer increase with aging. Age itself entails changes in the immune system, which are related to a decrease in thymic output of naïve lymphocytes, an accumulation of chronic antigenic load, notably chronic viral infections such as cytomegalovirus (CMV), and replicative senescence of lymphocytes. These changes could eventually contribute to cancer risk and affect the response to cancer treatment. However, several confounding factors make it difficult to draw a picture of causal relationships...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28258440/comprehensive-characterization-of-genes-associated-with-the-tp53-signal-transduction-pathway-in-various-tumors
#10
Shumpei Ohnami, Keiichi Ohshima, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Junko Saito, Akane Naruoka, Keiichi Hatakeyama, Tohru Mochizuki, Masakuni Serizawa, Sumiko Ohnami, Masatoshi Kusuhara, Ken Yamaguchi
The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic tumors, gastrointestinal stromal tumors, and renal cancers. The frequencies of non-synonymous single nucleotide variants (SNVs) in the TP53 family members TP63 and TP73 were relatively low, although genes with increased frequencies of SNVs were as follows: PTEN (11...
March 3, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28231294/association-of-neutrophil-lymphocyte-ratio-and-t-lymphocytes-with-the-pathogenesis-and-progression-of-hbv-associated-primary-liver-cancer
#11
Xiaoli Liu, Lingling He, Junyan Han, Lijia Wang, Mengge Li, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
BACKGROUND: The neutrophil-lymphocyte ratio (NLR) is a new prognostic predictor for patients with liver cancer. The association of NLR and T lymphocytes with the pathogenesis and progression of liver cancer is poorly understood. METHODS: Seventy-three patients with hepatitis B virus (HBV)-associated primary liver cancer (HBV-PLC), 50 patients with HBV-associated liver cirrhosis (HBV-LC) and 37 patients with chronic HBV infection (CHB) were prospectively enrolled from July 1, 2013 to February 28, 2014 in Beijing Ditan Hospital, Capital Medical University (Beijing, China)...
2017: PloS One
https://www.readbyqxmd.com/read/28162296/-efficacy-of-pd-1-pd-l1%C3%A2-immune-checkpoint-inhibitors-and-pd-l1%C3%A2-testing-in-thoracic-cancers
#12
Michaël Duruisseaux, Isabelle Rouquette, Julien Adam, Alexis Cortot, Aurélie Cazes, Laure Gibault, Diane Damotte, Sylvie Lantuejoul
Tumoral immune environment is a major component of cancer. Its composition and its organization represent a reproducible characteristic of tumors and a validated prognostic factor. In non-small cell lung cancer (NSCLC), cytotoxic T CD8+ lymphocyte density, associated with a Th1 environment and tertiary lymphoid structures impacts survival. Tumor cell-immune cell interaction is targeted by PD1/PD-L1 inhibitors. In advanced NSCLC, PD1/PD-L1 inhibitors are more effective than second-line chemotherapy. Pembrolizumab outperforms first-line chemotherapy in NSCLC strongly positive for PD-L1...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28134578/evolution-of-classification-of-thymic-epithelial-tumors-in-the-era-of-dr-thomas-v-colby
#13
REVIEW
Anja C Roden
CONTEXT: -Numerous histomorphologic and staging classifications of thymic epithelial tumors (TETs) have been proposed during the last century, suggesting that the classification of these tumors is challenging and controversial. Difficulties of classifying TETs include various combinations of epithelial cells and lymphocytes and the paucity of these tumors. The prognostic significance, specifically of the histomorphologic classifications, has been debated. Early classifications were also challenged by the uncertainty of the neoplastic component(s) of the tumor...
February 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28126540/the-impact-of-postoperative-radiotherapy-for-thymoma-and-thymic-carcinoma
#14
Matthew W Jackson, David A Palma, D Ross Camidge, Bernard L Jones, Tyler P Robin, David J Sher, Matthew Koshy, Brian D Kavanagh, Laurie E Gaspar, Chad G Rusthoven
INTRODUCTION: The optimal role for postoperative radiotherapy (PORT) for thymoma and thymic carcinoma remains controversial. We used the National Cancer Data Base to investigate the impact of PORT on overall survival (OS). METHODS: Patients who underwent an operation for thymoma or thymic carcinoma were categorized into Masaoka-Koga stage groups I to IIA, IIB, III, and IV. Patients who did not undergo an operation or those who received preoperative radiation were excluded...
January 25, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28119349/expression-of-pten-and-its-pseudogene-ptenp1-and-promoter-methylation-of-pten-in-non-tumourous-thymus-and-thymic-tumours
#15
Atsuko Masunaga, Mutsuko Omatsu, Toshiaki Kunimura, Shugo Uematsu, Yoshito Kamio, Akihiko Kitami, Yohei Miyagi, Kenzo Hiroshima, Takashi Suzuki
AIMS: Mutation or promoter methylation of the phosphatase tensin homologue deleted on chromosome 10 tumour suppressor gene (PTEN) promotes some cancers. Moreover, PTENP1 (PTEN pseudogene) transcript regulates PTEN expression and is thought to be associated with tumourigenesis in some cancers. Here, we investigated PTEN expression in thymic epithelium and thymic epithelial tumours. METHODS: Immunohistochemical analysis of PTEN was performed on two non-tumourous thymus (NT) samples, 33 thymomas (three type A, eight type AB, 11 type B1, six type B2, and five type B3), and four thymic carcinomas (TCs)...
January 24, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28106477/thymosin-alpha-1-and-hiv-1-recent-advances-and-future-perspectives
#16
Claudia Matteucci, Sandro Grelli, Emanuela Balestrieri, Antonella Minutolo, Ayele Argaw-Denboba, Beatrice Macchi, Paola Sinibaldi-Vallebona, Carlo Federico Perno, Antonio Mastino, Enrico Garaci
In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restore immune system homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction...
January 20, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28072694/effect-of-hyperthermic-intrathoracic-chemotherapy-hithoc-on-the-malignant-pleural-effusion-a-systematic-review-and-meta-analysis
#17
REVIEW
Hua Zhou, Wei Wu, Xiaoping Tang, Jianying Zhou, Yihong Shen
BACKGROUND: Although hyperthermic intraperitoneal chemotherapy (HIPEC) has been widely used to treat malignant ascites or as a preventive strategy for microscopic carcinomatosis following surgical resection of abdominal tumors, application of hyperthermic intrathoracic chemotherapy (HITHOC) in the treatment of malignant pleural effusion is limited. The objective of the current study was to conduct a systematic review and meta-analysis on the application of HITHOC in the palliative treatment of malignant pleural effusion...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28007263/thymic-and-mediastinal-lymph-node-metastasis-of-colon-cancer
#18
Yoko Yamamoto, Ken Kodama, Yoshihito Ide, Masashi Takeda
Most anterior mediastinal tumors are thymomas. Thymic metastasis from other primary cancers is extremely rare. We report the case of a 72-year-old man who developed thymic and mediastinal lymph node metastases of cecum cancer. He had undergone laparoscopic ileocecal resection with regional lymph node dissection for primary cecum cancer 15 months previously. Follow-up computed tomography revealed tumors in the anterior mediastinum. Fluorodeoxyglucose positron emission tomography showed positive uptake in the tumors...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28002319/response-of-mouse-thymic-cells-to-radiation-after-transfusion-of-mesenchymal-stem-cells
#19
Hongmei Zhang, Ling Wang, Chunlong Guo, Zhimin Tong, Yue Liu, Xiangkuan Meng, Hu Feng, Yubing Chen
Thymic lymphoma is a highly invasive and even metastatic cancer. This study investigated the effects of mesenchymal stem cells (MSCs) transfusion on cell cycle, cell proliferation, CD3 expression, mutation frequency of T cell receptor using mouse model of thymic lymphoma.C57BL/6J young mouse models of thymoma were injected with MSCs. Six months later, the thymus was taken for pathological examination and flow cytometry studies. The cells were labeled with anti-CD4, CD8, CD3, propidium iodide, or CFDA-SE, cell cycle, proliferation kinetics, and mutation frequency of T cell receptor, respectively...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27999073/prognostic-impact-of-tumour-size-in-completely-resected-thymic-epithelial-tumours
#20
Takayuki Fukui, Koichi Fukumoto, Toshiki Okasaka, Koji Kawaguchi, Shota Nakamura, Shuhei Hakiri, Naoki Ozeki, Akihiro Hirakawa, Hisashi Tateyama, Kohei Yokoi
OBJECTIVES: The T descriptor of thymic epithelial tumours proposed by the International Association for the Study of Lung Cancer and the International Thymic Malignancy Interest Group as well as the Masaoka-Koga system is defined by the anatomical extent of primary tumours, regardless of their size. However, the prognostic significance of tumour size in thymic epithelial tumours has not been fully elucidated. METHODS: We evaluated the prognostic significance of tumour size in 154 consecutive patients with thymic epithelial tumours including 124 thymomas, 21 thymic carcinomas and 9 neuroendocrine tumours, who underwent complete resection between 2001 and 2014...
December 2016: European Journal of Cardio-thoracic Surgery
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