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https://www.readbyqxmd.com/read/27902816/association-of-filaggrin-loss-of-function-and-thymic-stromal-lymphopoietin-variation-with-treatment-use-in-pediatric-atopic-dermatitis
#1
Joshua Chang, Nandita Mitra, Ole Hoffstad, David J Margolis
Importance: Atopic dermatitis (AD) is a common illness of childhood. Objective: To determine whether variations in FLG and TSLP genotype corresponded to differences in treatment use over time. Design, Setting, and Participants: This prospective cohort study recruited and followed a volunteer sample of 842 children enrolled in the Pediatric Eczema Elective Registry who provided saliva samples for DNA extraction for 10 years. Eligibility criteria included age 2 to 17 years, AD diagnosis without cancer, and prior pimecrolimus use...
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27900082/successful-treatment-of-advanced-thymic-carcinoma-with-lymph-node-and-pleural-metastases-a-case-report
#2
Yoko Yamamoto, Ken Kodama, Tomohiro Maniwa, Hiroki Kishima
Thymic carcinoma is a rare type of cancer that is more aggressive and is associated with a poorer prognosis compared with thymoma. No definitive clinical management of this disease has been established to date. This report describes the 20-year clinical course of a 50-year-old male patient who was successfully treated for initially diagnosed stage IVb thymic carcinoma. Thymo-thymectomy combined with resection of the surrounding organs was performed on December 1995 with curative intent (R0) after neoadjuvant chemoradiotherapy...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27899804/casein-kinase-2-controls-the-survival-of-normal-thymic-and-leukemic-%C3%AE-%C3%AE-t-cells-via-promotion-of-akt-signaling
#3
S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
The thymus is the major site for normal and leukemic T-cell development. The dissection of the molecular determinants of T-cell survival and differentiation is paramount for the manipulation of healthy or transformed T cells in cancer (immuno)therapy. Casein Kinase 2 (CK2) is a serine-threonine protein kinase whose anti-apoptotic functions have been described in various hematological and solid tumors. Here we disclose an unanticipated role of CK2 in healthy human thymocytes that is selective to the γδ T-cell lineage...
November 30, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#4
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
November 21, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27865176/adoptive-immunotherapy-for-hematological-malignancies-current-status-and-new-insights-in-chimeric-antigen-receptor-t-cells
#5
REVIEW
Alessandro Allegra, Vanessa Innao, Demetrio Gerace, Doriana Vaddinelli, Caterina Musolino
Hematological malignancies frequently express cancer-associated antigens that are shared with normal cells. Such tumor cells elude the host immune system because several T cells targeted against self-antigens are removed during thymic development, and those that persist are eliminated by a regulatory population of T cells. Chimeric antigen receptor-modified T cells (CAR-Ts) have emerged as a novel modality for tumor immunotherapy due to their powerful efficacy against tumor cells. These cells are created by transducing genes-coding fusion proteins of tumor antigen-recognition single-chain Fv connected to the intracellular signaling domains of T cell receptors, and are classed as first-, second- and third-generation, differing on the intracellular signaling domain number of T cell receptors...
November 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27829150/programmed-death-1-culls-peripheral-accumulation-of-high-affinity-autoreactive-cd4%C3%A2-t-cells-to-protect-against-autoimmunity
#6
Tony T Jiang, Tijana Martinov, Lijun Xin, Jeremy M Kinder, Justin A Spanier, Brian T Fife, Sing Sing Way
Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here, we show an essential role for the coinhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreactive CD4 T cells. Each wave of self-reactive CD4 T cells that escapes thymic deletion autonomously upregulates PD-1 to maintain self-tolerance. By tracking the progeny derived from individual autoreactive CD4 T cell clones, we demonstrate that self-reactive cells with the greatest autoimmune threat and highest self-antigen affinity express the most PD-1...
November 8, 2016: Cell Reports
https://www.readbyqxmd.com/read/27793024/absence-of-erk5-mapk7-delays-tumorigenesis-in-atm-mice
#7
Alba Granados-Jaén, Maria Angulo-Ibáñez, Xavier Rovira-Clavé, Celina Paola Vasquez Gamez, Francesc X Soriano, Manuel Reina, Enric Espel
Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis. MAPK7 has been implicated in numerous types of cancer with pro-survival and pro-growth roles in tumor cells, but its functional relation with tumor suppressors is not clear. In this study, we show that absence of MAPK7 delays death due to spontaneous tumor development in Atm-/- mice...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27789964/rare-frequency-of-gene-variation-and-survival-analysis-in-thymic-epithelial-tumors
#8
Zhengbo Song, Xinmin Yu, Yiping Zhang
OBJECTIVE: Thymic epithelial tumor (TET) is a rare mediastinal neoplasm and little is known about its genetic variability and prognostic factors. This study investigated the genetic variability and prognostic factors of TET. PATIENTS AND METHODS: We sequenced 22 cancer-related hotspot genes in TET tissues and matched normal tissues using Ampliseq Ion Torrent next-generation technology. Overall survival was evaluated using Kaplan-Meier methods and compared with log-rank tests...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27753538/expression-and-prognostic-significance-of-the-autoimmune-regulator-gene-in-breast-cancer-cells
#9
Francesca Bianchi, Michele Sommariva, Loris De Cecco, Tiziana Triulzi, Sandra Romero-Cordoba, Elda Tagliabue, Lucia Sfondrini, Andrea Balsari
The autoimmune regulator gene (AIRE) plays a fundamental role in tolerance by promoting the expression of tissue-specific antigens in medullary thymic epithelial cells (mTECs). Recently, AIRE expression was detected also in human keratinocytes and in tumors originating in stratified epithelia. Here, we tested whether AIRE is expressed in cancer cells. We analyzed AIRE expression in cancer cases from The Cancer Genome Atlas (TCGA) RNA-seq dataset and we found association with better outcome. AIRE protein expression was verified by immunohistochemistry in a cohort of 39 human breast cancer specimens and its prognostic relevance was confirmed in microarray-based gene expression dataset NKI-295 and KM-Plotter...
October 18, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27735079/dataset-for-reporting-of-thymic-epithelial-tumours-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#10
Andrew G Nicholson, Frank Detterbeck, Alexander Marx, Anja C Roden, Alberto M Marchevsky, Kiyoshi Mukai, Gang Chen, Mirella Marino, Michael A den Bakker, Woo-Ick Yang, Meagan Judge, Lynn Hirschowitz
AIMS: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists-Association Canadienne des Pathologists (CAP-ACP) in association with the Canadian Partnership Against Cancer (CPAC), and the European Society of Pathology (ESP). Its goal is to produce standardised, internationally agreed, evidence-based datasets for use throughout the world...
October 13, 2016: Histopathology
https://www.readbyqxmd.com/read/27720478/erratum-to-sunitinib-in-patients-with-advanced-thymic-malignancies-cohort-from-the-french-rythmic-network-lung-cancer-97-july-2016-99-104
#11
Jordi Remon, Nicolas Girard, Julien Mazieres, Eric Dansin, Eric Pichon, Laurent Greillier, Catherine Dubos, Colin R Lindsay, Benjamin Besse
No abstract text is available yet for this article.
October 6, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27693939/irreversible-electroporation-inhibits-pro-cancer-inflammatory-signaling-in-triple-negative-breast-cancer-cells
#12
Ishan Goswami, Sheryl Coutermarsh-Ott, Ryan G Morrison, Irving C Allen, Rafael V Davalos, Scott S Verbridge, Lissett R Bickford
Low-level electric fields have been demonstrated to induce spatial re-distribution of cell membrane receptors when applied for minutes or hours. However, there is limited literature on the influence on cell signaling with short transient high-amplitude pulses typically used in irreversible electroporation (IRE) for cancer treatment. Moreover, literature on signaling pertaining to immune cell trafficking after IRE is conflicting. We hypothesized that pulse parameters (field strength and exposure time) influence cell signaling and subsequently impact immune-cell trafficking...
February 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/27688088/diagnostic-roles-of-muc1-and-glut1-in-differentiating-thymic-carcinoma-from-type-b3-thymoma
#13
Ms Jun Du, Qin Shen, Honglin Yin, Qiu Rao, Mr Xiaojun Zhou
MUC1 is a transmembrane mucin that has been related to tumor progression and outcome in various malignancies. GLUT1 is a member of the mammalian facilitative glucose transporter (GLUT) family of passive carriers that functions as an energy-independent system for transporting glucose. Both of them are useful markers for the diagnosis, progression, and prognosis of various tumors, especially those that are cancerous. However, the clinical significance of MUC1 and GLUT1 in thymic epithelial tumors remains uncertain due to a lack of quality specimen and studies at sufficient scale, both owing, in part, to the rarity of the tumors...
November 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27666554/-erratum-pretreatment-biopsy-for-histological-diagnosis-and-induction-therapy-in-thymic-tumors
#14
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27651932/trends-and-current-status-of-general-thoracic-surgery-in-japan-revealed-by-review-of-nationwide-databases
#15
REVIEW
Meinoshin Okumura
Nationwide databases of cases treated for thoracic disease have been established by several academic associations in Japan, which contain information showing trends and current status in regard to surgical treatment. The Japanese Association of Thoracic Surgery (JATS), Japanese Association of Chest Surgery (JACS), Japan Lung Cancer Society (JLCS), Japanese Respiratory Society (JRS), and Japan Society for Respiratory Endoscopy (JSRE) have maintained databases of lung cancer cases treated in Japan. In 1986, the number of general thoracic surgery cases was 15,544, which increased to 75,306 in 2013...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27628324/mash1-is-highly-specific-for-neuroendocrine-carcinomas-an-immunohistochemical-evaluation-on-normal-and-various-neoplastic-tissues
#16
David Altree-Tacha, Jillian Tyrrell, Faqian Li
Context .- High-grade neuroendocrine carcinomas and carcinoids can arise in different sites such as lung, gastrointestinal tract, prostate, and skin. Classic neuroendocrine markers such as CD56, synaptophysin, and chromogranin cannot distinguish carcinoids from high-grade neuroendocrine carcinomas. Recently, mouse monoclonal mASH1 has been shown to help discriminate carcinoids from high-grade neuroendocrine carcinomas in various neoplastic sites. To date, there have been no comprehensive immunohistochemistry studies with mASH1 on nonneuroendocrine neoplasms...
September 15, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27625910/thymic-tumor-extension-into-the-heart-a-rare-finding-found-by-point-of-care-ultrasound
#17
Elizabeth Kaufman, Michelle Hunter-Behrend, Eric Leroux, Laleh Gharahbaghian, Viveta Lobo
We report a cardiac mass detected by point-of-care ultrasound performed within the emergency department on a 65-year-old male with thymic cancer who presented with chronic cough and fever. Results from the initial emergency workup, which included blood tests, urinalysis, and a computerized tomography with angiography scan with venous phasing of the chest, did not result in a definitive diagnosis. A point-of-care echocardiogram was performed to evaluate for possible infective endocarditis, but alternatively identified a large mass in the right atria and ventricle...
August 4, 2016: Curēus
https://www.readbyqxmd.com/read/27622057/no-evidence-for-tslp-pathway-activity-in-human-breast-cancer
#18
Cristina Ghirelli, Benjamin Sadacca, Fabien Reyal, Raphaël Zollinger, Paula Michea, Philémon Sirven, Lucia Pattarini, Carolina Martínez-Cingolani, Maude Guillot-Delost, André Nicolas, Alix Scholer-Dahirel, Vassili Soumelis
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that primes dendritic cells for Th2 induction. It has been implicated in different types of allergic diseases. Recent work suggested that TSLP could play an important role in the tumor microenvironment and influence tumor progression, in particular in breast cancer. In this study we systematically assessed the production of TSLP at the mRNA and protein levels in several human breast cancer cell lines, large-scale public transcriptomics data sets, and primary human breast tumors...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27622034/ligand-receptor-dissociated-expression-explains-high-tslp-without-prognostic-impact-in-human-primary-head-and-neck-squamous-cell-carcinoma
#19
Maude Guillot-Delost, Lia Guilleré, Frédérique Berger, Aurore Ventre, Paula Michea, Philémon Sirven, Lucia Pattarini, Alix Scholer-Dahirel, Fatima-Zahra Kebir, Michel Huerre, Olfa Chouchane-Mlik, Emmanuelle Lappartient, José Rodriguez, Thomas Jouffroy, Jerzy Klijanienko, André Nicolas, Xavier Sastre-Garau, Sofia Honorio, Véronique Mosseri, Nelly Le Peltier, Marie-Paule Sablin, Christophe Le Tourneau, Éric Tartour, Cécile Badoual, Vassili Soumelis
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine expressed by epithelial cells during allergic inflammation, and activating dendritic cells (DC). Its expression and functional role in cancer remain controversial. We conducted retrospective (n = 89), and prospective studies including patients with untreated primary head and neck squamous cell carcinoma (HNSCC). We found that TSLP was overexpressed by HNSCC tumor cells, and associated with a highly differentiated status. However, no significant difference in overall and recurrence-free survival was found between patients bearing a tumor with high and low TSLP levels, respectively...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27619979/the-international-association-for-the-study-of-lung-cancer-the-international-thymic-malignancies-interest-group-proposal-for-the-tnm-staging-systems-for-thymic-epithelial-tumors-and-large-scale-retrospective-data
#20
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