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https://www.readbyqxmd.com/read/29031170/a-dose-escalation-study-of-bi-daily-once-weekly-oral-docetaxel-either-as-modradoc001-or-modradoc006-combined-with-ritonavir
#1
Vincent A de Weger, Frederik E Stuurman, Jeroen J M A Hendrikx, Johannes J Moes, Emilia Sawicki, Alwin D R Huitema, Bastiaan Nuijen, Bas Thijssen, Hilde Rosing, Marianne Keessen, Marja Mergui-Roelvink, Jos H Beijnen, Jan H M Schellens, Serena Marchetti
INTRODUCTION: Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and investigated in a bi-daily once weekly (BIDW) schedule. Safety, maximum tolerated dose (MTD), pharmacokinetics (PK) and preliminary activity were explored. METHODS: Adult patients with metastatic solid tumours were included in two dose-escalation arms. PK sampling was performed during the first week and the second or third week...
October 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29029033/trial-evaluating-ambulatory-therapy-of-travelers-diarrhea-treat-td-study-a-randomized-controlled-trial-comparing-3-single-dose-antibiotic-regimens-with-loperamide
#2
Mark S Riddle, Patrick Connor, Jamie Fraser, Chad K Porter, Brett Swierczewski, Emma J Hutley, Brook Danboise, Mark P Simons, Christine Hulseberg, Tahaniyat Lalani, Ramiro L Gutierrez, David R Tribble
Background: Recommended treatment for travelers' diarrhea includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide for rapid resolution of symptoms. However, adverse events, postdose nausea with high-dose azithromycin, effectiveness of single-dose rifaximin, and emerging resistance to front-line agents are evidence gaps underlying current recommendations. Methods: A randomized, double-blind trial was conducted in 4 countries (Afghanistan, Djibouti, Kenya, and Honduras) between September 2012 and July 2015...
September 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028778/essential-oils-and-gastroparesis-power-for-transforming-health-hope-and-quality-of-life
#3
Chalyce Macoskey, Dorothy J Dunn
This study explored how essential oils for persons with gastroparesis symptoms affect the quality of life. Gastroparesis is a chronic delayed gastric motility disorder characterized by postprandial fullness, early satiety, nausea, vomiting, abdominal discomfort, bloating, depression, and anxiety. The aim of this study was to determine how essential oils support digestion and eliminate inflammation in the body as evidenced by self-reporting a decrease in symptoms, thereby improving quality of life. A qualitative descriptive methodology using Barrette's Theory of Power as Knowing Participation in Change thematic framework was used...
November 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29028126/leukocytoclastic-vasculitis-presenting-in-association-with-coxiella-burnetii-q-fever-a-case-report
#4
Stephen S Koh, Aldon Li, David S Cassarino
Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41 year old male complaining of body aches, fevers, nausea, malaise, bilateral knee pain, and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Workup revealed positive serologic testing for C burnetii and skin biopsy of the rash revealed leukocytoclastic vasculitis...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29027771/two-different-placement-paths-in-popliteal-fossa-with-a-novel-nerve-block-needle-with-external-indwelling-cannula-for-postoperative-analgesia-after-foot-and-ankle-surgery-a-randomized-controlled-trial
#5
Miao He, Dandan Ling, Guang-Yu Cai, Tian-Xiao Zou, Bin Yu
BACKGROUND: Previous studies have documented that single injection nearby the sciatic nerve bifurcation would influence the anesthesia and analgesia effect. But this is uncertain for preoperative continuous popliteal sciatic nerve block. So we conducted this trial to compare two paths (proximal to the bifurcation and at the bifurcation) of ultrasound guided continuous popliteal sciatic nerve block in foot and ankle surgery. METHODS: 40 recruited objects were randomly assigned to receive ultrasound-guided continuous popliteal sciatic nerve block at the puncture path proximal to the nerve bifurcation either at the nerve bifurcation...
October 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29027770/bispectral-index-bis-and-non-bis-anesthetic-protocols-on-postoperative-recovery-outcomes-a-systematic-review-and-meta-analysis
#6
Min-Hsien Chiang, Shao-Chun Wu, Shih-Wei Hsu, Jo-Chi Chin
BACKGROUND: The study aimed to compare bispectral index (BIS) and non-BIS anesthetic protocols on postoperative recovery outcomes. METHODS: Medline, PubMed, Cochrane, EMBASE, and Google Scholar databases were searched until January 21, 2016. RESULTS: Twenty-six studies were included with a total of 9537 patients. BIS monitoring was significantly associated with shorter time to eye opening (P=0.001), time to extubation (P<0.001), and time to orientation (P=0...
October 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29027621/use-of-carboxyhemoglobin-as-a-biomarker-of-environmental-co-exposure-critical-evaluation-of-the-literature
#7
Agnese Veronesi, Valentina Pecoraro, Stefano Zauli, Marta Ottone, Giovanni Leonardi, Paolo Lauriola, Tommaso Trenti
Carbon monoxide (CO) poisoning is the primary cause for access to emergency department (ED) services for more than 50,000 persons in Europe and the USA every year. CO poisoning diagnosis is based on multiple factors and is usually confirmed by high carboxyhemoglobin (COHb) levels in the blood. We conducted a systematic evaluation of literature to investigate the usefulness of COHb as a biomarker of environmental CO exposure. We conducted an electronic search in Medline, Embase, and the Cochrane Library databases...
October 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29026668/fourth-ventricle-neurocysticercosis-rigid-endoscopic-management-description-of-direct-transcerebellar-approach
#8
A Ceja-Espinosa, J A Franco-Jiménez, A Sosa-Nájera, G A Gutiérrez-Aceves, M I Ruiz-Flores
BACKGROUND: Endoscopy has gained a crucial role in high specialty neurosurgery during the last decades. At present, there are well-defined flexible neuroendoscopic procedures to treat ventricular and subarachnoid space pathologies. Neurocysticercosis is recognized as a common cause of neurologic disease in developing countries and the United States. Surgical intervention, especially cerebrospinal fluid diversion, is the key for management of hydrocephalus. In 2002, a consensus suggested that ventricular forms should be treated with endoscopy as the first option...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026493/an-uncommon-side-effect-of-a-commonly-used-antibiotic-amoxicillin-clavulanic-acid-induced-hepatitis
#9
Vinay Mathew Thomas, Neena Thomas-Eapen
Amoxicillin-Clavulanic acid continues to be one of the most commonly used antibiotic combinations. Hepatic injury due to this antibiotic is rare. We report a case of amoxicillin-clavulanic acid induced hepatitis causing painless jaundice to bring to attention this rare side effect of this commonly used antibiotic. This is a case of a 62-year-old Caucasian female, who presented with acute onset severe painless jaundice, nausea, vomiting, and pruritus of less than 1-week duration. She had completed a course of amoxicillin-clavulanic acid 3 weeks prior to presentation...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29026385/a-randomized-controlled-trial-to-assess-the-effect-of-a-ketamine-infusion-on-tourniquet-hypertension-during-general-anaesthesia-in-patients-undergoing-upper-and-lower-limb-surgery
#10
Joyce Ongaya, Vitalis Mung'ayi, Thikra Sharif, Jimmie Kabugi
BACKGROUND: Tourniquet hypertension arising from tourniquet inflation remains a primary concern to the anaesthetist. One drug commonly used to manage tourniquet hypertension is ketamine. No studies have examined the effect of ketamine on tourniquet hypertension for a period of more than one hour or an infusion of the same. OBJECTIVE: To compare the effect of an intravenous infusion of ketamine versus placebo on tourniquet induced hypertension in patients undergoing upper and lower limb surgery under general anaesthesia...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026334/an-investigation-into-the-effect-of-depth-of-anesthesia-on-postoperative-pain-in-laparoscopic-cholecystectomy-surgery-a-double-blind-clinical-trial
#11
Seyed Hamid Reza Faiz, Seyed Alireza Seyed Siamdoust, Poupak Rahimzadeh, Leila Houshmand
BACKGROUNDS AND OBJECTIVE: Some studies have shown that deeper anesthesia is more effective on postoperative analgesia and reduces the need for sedative drugs. This study sought to investigate the effect of depth of anesthesia on postoperative pain in laparoscopic cholecystectomy. MATERIALS AND METHODS: In this double-blind clinical trial, 60 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups: low bispectral index (L-BIS=35-44) and high bispectral index (H-BIS=45-55)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29024324/clinical-implications-of-gastrointestinal-symptoms-in-systemic-amyloidosis
#12
T Yen, F W Chen, R M Witteles, M Liedtke, L A Nguyen
BACKGROUND: Gastrointestinal (GI) symptoms in systemic amyloidosis patients are poorly characterized. This purpose of this study is to define the epidemiology and clinical implications of such symptoms. METHODS: This was a retrospective cohort study of 583 amyloid patients seen at a tertiary referral center. Of 96 symptomatic patients, 82 received endoscopic biopsies, subsequently grouped into those with histologic evidence of GI amyloid (biopsy proven) vs without (biopsy absent)...
October 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29020798/serum-bovine-immunoglobulin-for-chemotherapy-induced-gastrointestinal-mucositis
#13
Sowminya Arikapudi, Saima Rashid, Laith Adel Al Almomani, Jennifer Treece, Steven J Baumrucker
Cancer treatments including chemotherapy and radiotherapy treat cancer by targeting rapidly dividing cells. Although these forms of treatment damage rapidly dividing cancer cells, they are also toxic to the cells of the gastrointestinal tract, leading to inflammation of the mucosal layer (mucositis) and causing nausea, vomiting, diarrhea, and abdominal pain. Improvement in symptoms may allow patients to have better performance status permitting ongoing treatment and possibly a better prognosis. This article describes the pathophysiology of chemotherapy-induced mucositis and includes 3 case reports of treatment of mucositis with serum bovine immunoglobulin...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29020720/pyelonephritis-can-lead-to-life-threatening-complications
#14
Declan B Keenan, Declan M O'Rourke, Aisling E Courtney
Acute pyelonephritis is suggested by the constellation of fever (temperature ≥ 38.5° C), flank pain (typically unilateral), nausea and vomiting, and costovertebral angle tenderness. Complaints typical of lower UTI are variably present. The severity of symptoms ranges from a mild pyrexial illness to life-threatening sepsis. The diagnosis of acute pyelonephritis should be suspected on the basis of the history and clinical examination. If the urine dipstick is negative for nitrites and leukocyte esterase this does not exclude the diagnosis, but it should prompt a re-evaluation of the clinical features and consideration of other potential diagnoses...
February 2017: Practitioner
https://www.readbyqxmd.com/read/29019951/chemotherapy-related-toxicity-nutritional-status-and-quality-of-life-in-precachectic-oncologic-patients-with-or-without-high-protein-nutritional-support-a-prospective-randomized-study
#15
Monika Ziętarska, Joanna Krawczyk-Lipiec, Leszek Kraj, Renata Zaucha, Sylwia Małgorzewicz
BACKGROUND: Cancer disease is usually associated with impaired nutritional status, which is one of the factors contributing to deterioration of the results of surgery, chemotherapy or radiotherapy. OBJECTIVES: The aim of the study was to determine whether nutritional support with high protein (ONS) in adult oncologic patients in the first step of cancer cachexia-asymptomatic precachexia, has an influence on the toxicity of systemic therapy. However, secondary endpoints were established: to determine whether high protein ONS influences the nutritional status, the quality of life, and the performance status...
October 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29019899/effect-of-cerebral-oxygen-saturation-on-postoperative-nausea-and-vomiting-in-female-laparoscopic-surgery-patients
#16
WenJun Guo, Jie Ding, XiaoJu Jin, GaoJie Li
BACKGROUND: The purpose of this study was to investigate effect of cerebral oxygen saturation (SCTO2) on postoperative nausea and vomiting (PONV) in female patients who underwent laparoscopic surgery. METHODS: This study included 90 female patients who underwent laparoscopic surgery (60 cases of gynecological operations and 30 cases of gallbladder operations). All patients were allocated into 3 groups of 30 patients each: group A (gynecological laparoscopic surgery), group B (gynecological laparoscopic surgery with mannitol treatment) and group C (laparoscopic cholecystectomy surgery)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019889/high-dose-of-nimustine-as-an-add-on-treatment-for-small-cell-lung-cancer-with-intracranial-metastasis-a-case-report-and-literature-review
#17
Wei Luo, Ya-Lun Li, Ya Juan Chen, Qing Xiang, Hong Chen
RATIONALE: Small cell lung cancer (SCLC) characterized by high degree of malignancy and rapid tumor progression. Intracranial metastases often appear at the time of the initial diagnosis or treatment. Besides of radiotherapy, chemotherapy is supposed to have limited effect. PATIENT CONCERNS: A 66-year-old male had blurred vision and unsteady step with moderate headache, nausea, vomit. DIAGNOSES: The patient was diagnosed with SCLC with intracranial metastases...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019885/two-incision-laparoscopic-appendectomy-for-a-severe-hemophilia-a-child-patient-with-coagulation-factor-vii-deficiency-case-report-and-review-of-literature
#18
Jin Peng He, Jie Xiong Feng
RATIONALE: The main complication of patients with severe hemophilia is recurrent bleeding events that usually affected musculoskeletal contractures. And replacement therapy methods were continuously improved to minimize adverse impacts brought by those complications. However, only several cases reported about the appendectomy for hemophilia A. We report a case of acute appendicitis treated by two-incision laparoscopy in a boy with hemophilia A and coagulation factor VII deficiency for the first time...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29018077/efficacy-of-venetoclax-as-targeted-therapy-for-relapsed-refractory-t-11-14-multiple-myeloma
#19
Shaji Kumar, Jonathan L Kaufman, Cristina Gasparetto, Joseph Mikhael, Ravi Vij, Brigitte Pegourie, Lofti Benboubker, Thierry Facon, Martine Amiot, Philippe Moreau, Elizabeth A Punnoose, Stefanie Alzate, Martin Dunbar, Tu Xu, Suresh K Agarwal, Sari Heitner Enschede, Joel D Leverson, Jeremy A Ross, Paulo C Maciag, Maria Verdugo, Cyrille Touzeau
Venetoclax is a selective, orally bioavailable BCL-2 inhibitor that induces cell death in MM cells, particularly in those harboring t(11;14), which express high levels of BCL-2 relative to BCL-XL and MCL-1. In this phase I study, patients with relapsed/refractory MM received venetoclax monotherapy. After a 2-week lead-in with weekly dose escalation, daily venetoclax was given at 300, 600, 900, or 1200 mg in dose-escalation cohorts and 1200 mg in the safety expansion. Dexamethasone could be added upon progression during treatment...
October 10, 2017: Blood
https://www.readbyqxmd.com/read/29016948/tertiary-care-clinical-experience-with-intravenous-lidocaine-infusions-for-the-treatment-of-chronic-pain
#20
Eli Iacob, Emily E Hagn, Jill Sindt, Shane Brogan, Scott C Tadler, Konrad S Kennington, Bradford D Hare, Christina E Bokat, Gary W Donaldson, Akiko Okifuji, Scott R Junkins
Objective: To evaluate the safety of and long-term pain relief due to intravenous lidocaine infusion for the treatment of chronic pain in a tertiary pain management clinic. Design: Retrospective chart review. Methods: Medical records were reviewed from 233 adult chronic pain patients who underwent one to three lidocaine infusions. The initial lidocaine challenge consisted of 1,000 mg/h administered intravenously for up to 30 minutes until infusion was complete, full pain resolution, the patient requested to stop, side effects (SEs) became intolerable, and/or if there were any safety concerns...
July 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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