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https://www.readbyqxmd.com/read/29933307/impact-of-comorbidity-on-symptoms-and-quality-of-life-among-patients-being-treated-for-breast-cancer
#1
Horng-Shiuann Wu, Jean E Davis, Ling Chen
BACKGROUND: Cancer patients often have other noncancer medical conditions. Presence of comorbidities negatively affects cancer survival. OBJECTIVE: The aim of this study was to investigate comorbidity, risk factors for comorbidity, and how comorbidity was associated with symptoms and quality of life in patients being treated for breast cancer. METHODS: One hundred and one breast cancer chemotherapy outpatients completed this study. Comorbid conditions, weight, height, and smoking status were identified by chart review...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933099/bariatric-patients-nutritional-status-as-a-risk-factor-for-postoperative-complications-prolonged-length-of-hospital-stay-and-hospital-readmission-a-retrospective-cohort-study
#2
Piotr Major, Piotr Małczak, Michał Wysocki, Grzegorz Torbicz, Natalia Gajewska, Michał Pędziwiatr, Andrzej Budzyński
BACKGROUND: The prevalence of obesity is growing worldwide. Malnutrition has been identified as a risk factor, leading to higher morbidity rate and prolonged length of hospital. So far there are no high quality data on the impact of malnutrition on length of hospital stay and morbidity regarding bariatric surgery. The aim of the study was to assess association between nutritional status and outcomes bariatric surgeries. MATERIAL AND METHODS: The study was a prospective observational study...
June 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29933085/gastroparesis-following-resection-of-a-fourth-ventricle-ependymoma-in-a-child
#3
Hong Zhang, Bing Qing, Jian Zheng
BACKGROUND: Gastroparesis following resection of a fourth ventricle tumor has never been reported in the literature. We report a unique case of gastroparesis following resection of a fourth ventricle ependymoma in a child. CASE DESCRIPTION: A 14-year-old boy presented with 12-day history of headache, nausea and vomiting. Magnetic resonance imaging revealed a tumor in the fourth ventricle. He underwent a posterior median craniotomy and total removal was achieved...
June 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29932431/too-deep-or-not-too-deep-a-propensity-matched-comparison-of-the-analgesic-effects-of-a-superficial-versus-deep-serratus-fascial-plane-block-for-ambulatory-breast-cancer-surgery
#4
Faraj W Abdallah, Tulin Cil, David MacLean, Caveh Madjdpour, Jaime Escallon, John Semple, Richard Brull
BACKGROUND AND OBJECTIVES: Serratus fascial plane block can reduce pain following breast surgery, but the question of whether to inject the local anesthetic superficial or deep to the serratus muscle has not been answered. This cohort study compares the analgesic benefits of superficial versus deep serratus plane blocks in ambulatory breast cancer surgery patients at Women's College Hospital between February 2014 and December 2016. We tested the joint hypothesis that deep serratus block is noninferior to superficial serratus block for postoperative in-hospital (pre-discharge) opioid consumption and pain severity...
July 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29932379/safety-and-efficacy-of-a-novel-neurosurgical-enhanced-recovery-after-surgery-protocol-for-elective-craniotomy-a-prospective-randomized-controlled-trial
#5
Yuan Wang, Bolin Liu, Tianzhi Zhao, Binfang Zhao, Daihua Yu, Xue Jiang, Lin Ye, Lanfu Zhao, Wenhai Lv, Yufu Zhang, Tao Zheng, Yafei Xue, Lei Chen, Eric Sankey, Long Chen, Yingxi Wu, Mingjuan Li, Lin Ma, Zhengmin Li, Ruigang Li, Juan Li, Jing Yan, Shasha Wang, Hui Zhao, Xude Sun, Guodong Gao, Yan Qu, Shiming He
OBJECTIVE Although enhanced recovery after surgery (ERAS) programs have gained acceptance in various surgical specialties, no established neurosurgical ERAS protocol for patients undergoing elective craniotomy has been reported in the literature. Here, the authors describe the design, implementation, safety, and efficacy of a novel neurosurgical ERAS protocol for elective craniotomy in a tertiary care medical center located in China. METHODS A multidisciplinary neurosurgical ERAS protocol for elective craniotomy was developed based on the best available evidence...
June 22, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29932006/semaglutide-the-newest-once-weekly-glp-1-ra-for-type-2-diabetes
#6
Rhianna M Tuchscherer, Angela M Thompson, Jennifer M Trujillo
OBJECTIVE: To review efficacy and safety of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide for type 2 diabetes (T2D). DATA SOURCES: A literature search of PubMed/MEDLINE and EMBASE using the term semaglutide was completed through April 2018. A search of clinicaltrials.gov was also conducted. STUDY SELECTION AND DATA EXTRACTION: English-language studies assessing the efficacy and/or safety of semaglutide were evaluated...
June 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29931490/the-impact-of-automated-screening-with-edmonton-symptom-assessment-system-esas-on-health-related-quality-of-life-supportive-care-needs-and-patient-satisfaction-with-care-in-268-ambulatory-cancer-patients
#7
Benjamin D Diplock, Kaitlin M C McGarragle, Willem A Mueller, Sana Haddad, Rachel Ehrlich, Dong-Hyun A Yoon, Xingshan Cao, Yaseen Al-Allaq, Paul Karanicolas, Margaret I Fitch, Jeff Myers, Alex J Mitchell, Janet W M Ellis
PURPOSE: We aimed to assess the impact of implementing Edmonton Symptom Assessment System (ESAS) screening on health-related quality of life (HRQoL) and patient satisfaction with care (PSC) in ambulatory oncology patients. ESAS is now a standard of care in Ontario cancer centers, with the goal of improving symptom management in cancer patients, yet few studies examine impact of ESAS on patient outcomes. METHODS: We compared ambulatory oncology patients who were not screened prior to ESAS site implementation (2011-2012), to a similar group who were screened using ESAS after site implementation (2012-2013), to examine between-group differences in patient HRQoL, PSC outcomes, and supportive care needs (Supportive Care Service Survey)...
June 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29929517/pneumococcal-meningitis-outbreak-and-associated-factors-in-six-districts-of-brong-ahafo-region-ghana-2016
#8
Timothy Letsa, Charles Lwanga Noora, George Khumalo Kuma, Ernest Asiedu, Gideon Kye-Duodu, Edwin Afari, Osei Afreh Kuffour, Joseph Opare, Kofi Mensah Nyarko, Donne Kofi Ameme, Emmanuel G Bachan, Kofi Issah, Franklin Aseidu-Bekoe, Moses Aikins, Ernest Kenu
BACKGROUND: Meningitis, a disease of the Central Nervous System is described as inflammation of the covering of the brain and spinal cord (meninges). It is characterised by fever, severe headache, nausea, vomiting, stiff neck, photophobia, altered consciousness, convulsion/seizures and coma. In December, 2015, twelve suspected cases of meningitis were reported in Tain district in Brong Ahafo region (BAR). Subsequently, dozens of suspected cases were hospitalized in five district hospitals in BAR...
June 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29928323/treatment-of-hepatic-metastases-with-computed-tomography-guided-interstitial-brachytherapy
#9
Dariusz Kieszko, Paweł Cisek, Izabela Kordzińska-Cisek, Ludmiła Grzybowska-Szatkowska
The aim of the present study was to evaluate the efficacy, safety and tolerability of local treatment of liver metastases of various types of cancer using brachytherapy with computed tomography (CT) imaging. Retrospective analysis of 61 patients with unresectable hepatic metastases treated with CT-guided interstitial high dose rate (HDR) brachytherapy of the liver between April 2014 and December 2016 was performed. Patients were treated with a single fractional dose of 15-25 Gy. Statistical analysis was performed on local relapse free survival (LRFS), progression free survival (PFS) and overall survival (OS) rates across the group...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29926478/medi0382-a-glp-1-glucagon-receptor-dual-agonist-meets-safety-and-tolerability-endpoints-in-a-single-dose-healthy-subject-randomised-phase-1-study
#10
Philip D Ambery, Sebastian Klammt, Maximillian G Posch, Marcella Petrone, Wenji Pu, Cristina Rondinone, Lutz Jermutus, Boaz Hirshberg
AIMS: MEDI0382 is a balanced glucagon-like peptide-1/glucagon receptor dual agonist under development for the treatment of type 2 diabetes mellitus and non-alcoholic steatohepatitis. The primary objective was to assess the safety of MEDI0382 in healthy subjects. METHODS: In this placebo-controlled, double-blind, phase 1 study, healthy subjects (aged 18-45 years) were randomised (3:1) to receive a single subcutaneous dose of MEDI0382 or placebo after ≥8 hours of fasting...
June 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29925253/using-clinical-indicators-to-reduce-perianesthesia-recovery-time-following-outpatient-tonsillectomy
#11
Habib G Zalzal, Chadi A Makary, Raquel Evans, Stacy Giardina, Tracy Underwood, Aletha Rowlands, Hassan H Ramadan
OBJECTIVE: To determine whether we could reduce the time that patients undergoing tonsillectomy are observed postoperatively without decreasing the quality of care, which would eliminate the unnecessary use of resources to monitor those patients. STUDY DESIGN: Prospective cohort. METHODS: Patients undergoing tonsillectomy were recruited for the study prior to their operation. Each patient was then monitored in perianesthesia recovery until clinical indicators for discharge readiness were met (baseline respiratory function, afebrile, ambulation per age, adequate consciousness, absence of nausea/vomiting, adequate pain control, no active bleeding, fluid toleration)...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29924051/consort-epidural-dexmedetomidine-improves-gastrointestinal-motility-after-laparoscopic-colonic-resection-compared-with-morphine
#12
Qiuxia Wan, Wengang Ding, Xiaoguang Cui, Xianzhang Zeng
BACKGROUND: We have previously shown that epidural dexmedetomidine, when used as an adjunct to levobupivacaine for control of postoperative pain after open colonic resection, improves recovery of gastrointestinal motility compared with morphine. METHODS: Sixty patients undergoing laparoscopic colonic resection were enrolled and allocated randomly to treatment with dexmedetomidine (group D) or morphine (group M). Group D received an epidural loading dose of dexmedetomidine (5 mL, 0...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924009/intensity-modulated-radiotherapy-combined-with-endostar-has-similar-efficacy-but-weaker-acute-adverse-reactions-than-imrt-combined-with-chemotherapy-in-the-treatment-of-locally-advanced-nasopharyngeal-carcinoma
#13
Min Kang, Fangfang Wang, Xueyin Liao, Pingting Zhou, Rensheng Wang
The present study is to compare the efficacy and adverse effects of intensity-modulated radiotherapy (IMRT) combined with endostar and IMRT combined with concurrent chemotherapy on locally advanced nasopharyngeal carcinoma (NPC).A total of 23 patients with stage III-IVa NPC were included in the present study, and randomly divided into experimental group (10 cases treated with IMRT + endostar) and control group (13 cases treated with IMRT + chemotherapy of cis-dichlorodiamineplatinum). Endostar was intravenously administered from the first day of IMRT...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924005/abdominal-cocoon-with-early-postoperative-small-bowel-obstruction-a-case-report-and-review-of-literature-in-china
#14
Jie Xia, WeiJia Xie, Li Chen, Daren Liu
RATIONALE: Abdominal cocoon is a condition in which intestinal obstruction results from the encasement of part or whole of the small bowel by a thick fibrous membrane, giving the appearance of a cocoon. The preoperative diagnosis is difficult to be made and the treatment is still controversial. PATIENT CONCERNS: Here we describe the case of a 62-year-old male presented with a 24-h history of continual colicky abdominal pain, which was accompanied with nausea and vomiting...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923997/euglycemic-diabetic-ketoacidosis-caused-by-dapagliflozin-a-case-report
#15
Yu-Mou Chou, Chen-June Seak, Zhong Ning Leonard Goh, Joanna Chen-Yeen Seak, Chen-Ken Seak, Chih-Chuan Lin
RATIONALE: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923616/medicinal-cannabinoids-in-palliative-care
#16
REVIEW
M Agar
The treatment of symptoms in people with palliative diagnoses begins with meticulous clinical assessment with treatment choice (s) selected based on an understanding of the symptom aetiology and the evidence which underpins its treatment. Increasingly the merits of palliative care have been established earlier in the disease trajectory where treatment outcomes may include increased survival and maintenance of function. There is strong public support for the availability of medicinal cannabis, particularly for people with palliative diagnoses...
June 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29923298/low-incidence-of-gastrointestinal-adverse-events-over-time-with-a-fixed-ratio-combination-of-insulin-glargine-and-lixisenatide-vs-lixisenatide-alone
#17
Jennifer M Trujillo, Michelle Roberts, Terry Dex, Jason Chao, Pa-C John White, James LaSalle
This post hoc analysis of gastrointestinal (GI) adverse events (AEs) from the phase 3 LixiLan-L (NCT02058160) and LixiLan-O (NCT02058147) trials aimed to determine the frequency and timing of nausea, vomiting, and diarrhea for iGlarLixi, a titratable, fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide, vs iGlar alone or iGlar and lixisenatide alone, in patients with type 2 diabetes uncontrolled with oral antidiabetes drugs (OADs) or basal insulin ± OADs. In iGlarLixi-treated patients, the rate of GI AEs during initial weeks of treatment was lower vs patients treated with lixisenatide alone (9...
June 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29922464/gallstone-ileus-of-the-sigmoid-colon-caused-by-cholecystocolonic-fistula-a-case-report
#18
González-Urquijo Mauricio, Hinojosa-Gonzalez David Eugenio, Quevedo-Fernandez Enrique
Introduction: A cholecystocolonic fistula (CCF) is a late complication following repeated episodes of chronic inflammation of the gallbladder in contact with the hepatic flexure, and it might cause a biliary ileus in the colon, causing an intestinal obstruction, and if left untreated, a life threatening disease. Presentation of case: a 49-year-old female patient presented with abdominal pain and bowel obstruction due to a gallstone impaction on the sigmoid colon as consequence of a cholecystocolonic fistula...
July 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29922214/clinical-features-of-headache-in-patients-with-diagnosis-of-definite-vestibular-migraine-the-vm-phenotypes-projects
#19
Roberto Teggi, Bruno Colombo, Roberto Albera, Giacinto Asprella Libonati, Cristiano Balzanelli, Angel Batuecas Caletrio, Augusto P Casani, Juan Manuel Espinosa-Sanchez, Paolo Gamba, Jose A Lopez-Escamez, Sergio Lucisano, Marco Mandalà, Giampiero Neri, Daniele Nuti, Rudi Pecci, Antonio Russo, Eduardo Martin-Sanz, Ricardo Sanz, Gioacchino Tedeschi, Paola Torelli, Paolo Vannucchi, Giancarlo Comi, Mario Bussi
Migraine is a common neurological disorder characterized by episodic headaches with specific features, presenting familial aggregation. Migraine is associated with episodic vertigo, named Vestibular Migraine (VM) whose diagnosis mainly rely on clinical history showing a temporary association of symptoms. Some patient refers symptoms occurring in pediatric age, defined "episodic symptoms which may be associated with migraine." The aim of this cross sectional observational study was to assess migraine-related clinical features in VM subjects...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29921320/phase-ia-study-of-the-indoleamine-2-3-dioxygenase-1-ido1-inhibitor-navoximod-gdc-0919-in-patients-with-recurrent-advanced-solid-tumors
#20
Asha Nayak-Kapoor, Zhonglin Hao, Ramses Sadek, Robin Dobbins, Lisa Marshall, Nicholas N Vahanian, W Jay Ramsey, Eugene Kennedy, Mario R Mautino, Charles J Link, Ray S Lin, Stephanie Royer-Joo, Xiaorong Liang, Laurent Salphati, Kari M Morrissey, Sami Mahrus, Bruce McCall, Andrea Pirzkall, David H Munn, John E Janik, Samir N Khleif
BACKGROUND: Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 small molecule inhibitor navoximod (GDC-0919, NLG-919) is active as a combination therapy in multiple tumor models. METHODS: This open-label Phase Ia study assessed safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of navoximod in patients with recurrent/advanced solid tumors, administered as 50-800 mg BID on a 21/28 day and at 600 mg on a 28/28 day schedule...
June 20, 2018: Journal for Immunotherapy of Cancer
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