Miguel A Martínez-López, Sara Rubio-Casado, Diego San Felipe, Beatriz Martín-Sánchez, José A Fernández-Albarral, Elena Salobrar-García, José A Matamoros, José M Ramírez, Rosa de Hoz, Juan J Salazar, Eva M Marco, Ana I Ramírez, Alberto Lázaro, Meritxell López-Gallardo
Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to evaluate the protective role of cilastatin (CIL), generally used in the treatment of nephropathologies associated with inflammation, in an experimental mouse model based on unilateral (left) laser-induced ocular hypertension (OHT). Male Swiss mice were administered CIL daily (300 mg/kg, i.p.) two days before OHT surgery until sacrifice 3 or 7 days later. Intraocular Pressure (IOP), as well as retinal ganglion cell (RGC) survival, was registered, and the inflammatory responses of macroglial and microglial cells were studied via immunohistochemical techniques...
March 7, 2024: International Journal of Molecular Sciences