keyword
MENU ▼
Read by QxMD icon Read
search

Neuroprotective

keyword
https://www.readbyqxmd.com/read/28741457/anthocyanins-possible-role-as-multitarget-therapeutic-agents-for-prevention-and-therapy-of-chronic-diseases
#1
Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V Tarasov, Vladimir N Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T Scotti, M A Kamal, Gjumrakch Aliev, Chinthalapally V Rao, George Perry, Anupam Bishayee
Anthocyanins belong to the flavonoids class of polyphenols and they are water soluble dark colored natural pigments from fruits and vegetables. Dietary consumption of anthocyanins is high compared to other flavonoids, owing to their wide distribution in plant materials. Anthocyanins are the active component in several herbal folk medicines due to its multifaceted medicinal properties. METHOD: This review discusses the anthocyanins as multitarget drugs, which posses antioxidant, antidiabetic, antihyperlipidemic, anti inflammatory, anticarcinogenic, antiulcer, cardioprotective, hepatoprotective, neuroprotective role...
May 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28741035/biomarkers-of-hepatic-injury-and-function-in-neonatal-hypoxic-ischemic-encephalopathy-and-with-therapeutic-hypothermia
#2
Hemananda Muniraman, Danielle Gardner, Jane Skinner, Anna Paweletz, Anitha Vayalakkad, Ying Hui Chee, Clare Clifford, Sunil Sanka, Vidheya Venkatesh, Anna Curley, Suresh Victor, Mark A Turner, Paul Clarke
Therapeutic hypothermia (TH) is now provided as standard care to infants with moderate-severe hypoxic ischemic encephalopathy (HIE). The role of TH in limiting neuronal injury is well recognized, but its effect on hepatic injury which occurs frequently in neonatal HIE is not known. Our objective was to characterize biomarkers of liver injury and function in the setting of neonatal HIE and to describe whether HIE severity and provision of TH influence these hepatic biomarkers. We performed a multicenter retrospective study and compared hepatic biomarkers obtained during the first postnatal week, according to the severity of HIE and whether treated with TH...
July 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28741014/post-resuscitation-care
#3
Sohil Pothiawala
Following return of spontaneous circulation (ROSC) after cardiac arrest, the challenge is to institute measures that ensure a higher likelihood of neurologically intact survival. Regardless of the cause of collapse, multiple organ systems may be affected secondary to post-cardiac arrest syndrome. Interventions required for post-ROSC care are bundled into a care regimen: prompt identification and treatment of the cause of cardiac arrest; and treatment of electrolyte abnormalities. It is also essential to establish definitive airway management to maintain normocapnic ventilation, prevent hyperoxia, and optimise haemodynamic management via judicious intravenous fluids and vasoactive drugs...
July 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28740732/low-molecular-weight-ngf-mimetic-corrects-the-cognitive-deficit-and-depression-like-behavior-in-experimental-diabetes
#4
R U Ostrovskaya, S S Yagubova, T A Gudasheva, S B Seredenin
Based on the comorbidity of diabetes, depression, and dementia and recognizing that a deficiency of the nerve growth factor (NGF) is involved in all of these kinds of pathologies, we studied the effect of the mimetic of dimeric dipeptide NGF loop 4, GK-2, on a model of streptozotocin-induced type 2 diabetes in C57Bl/6 mice. GK-2 [hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine)] was synthesized at the V.V. Zakusov Scientific Research Institute of Pharmacology. The study revealed the ability of GK-2 to ameliorate hyperglycemia induced by streptozotocine (STZ 100 mg/kg i...
April 2017: Acta Naturae
https://www.readbyqxmd.com/read/28740571/comparison-of-the-neuroprotective-and-anti-inflammatory-effects-of-the-anthocyanin-metabolites-protocatechuic-acid-and-4-hydroxybenzoic-acid
#5
Aimee N Winter, Matthew C Brenner, Noelle Punessen, Michael Snodgrass, Caleb Byars, Yingyot Arora, Daniel A Linseman
Anthocyanins are being increasingly investigated for their neuroprotective and antineuroinflammatory effects; however, the overall bioavailability of many anthocyanins is relatively low. In contrast, phenolic acids, metabolites of many polyphenols, including anthocyanins, have been shown to accumulate in tissue at higher concentrations than those of parent compounds, suggesting that these metabolites may be the bioactive components of anthocyanin-rich diets. We examined the neuroprotective capacity of two common phenolic acids, 4-hydroxybenzoic acid (HBA) and protocatechuic acid (PCA), in primary cultures of cerebellar granule neurons...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28739248/the-protective-effect-of-hydrogen-sulfide-h2s-on-traumatic-brain-injury-tbi-induced-memory-deficits-in-rats
#6
Seyed Asaad Karimi, Narges Hosseinmardi, Mahyar Janahmadi, Mohammad Sayyah, Razieh Hajisoltani
Traumatic brain injury (TBI), as an expanding public health epidemic, is a common cause of death among youth. TBI is associated with cognitive deficits and memory impairment. Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the central nervous system. In the present study the potential neuroprotective role of sodium hydrosulfide (NaHS), an H2S donor on TBI induced memory deficit in a rat model of controlled cortical impact (CCI) injury was investigated...
July 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28738875/effects-of-fty720-on-brain-neurogenic-niches-in-vitro-and-after-kainic-acid-induced-injury
#7
Raffaela Cipriani, Juan Carlos Chara, Alfredo Rodríguez-Antigüedad, Carlos Matute
BACKGROUND: FTY720 (fingolimod, Gilenya™) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts several effects in the central nervous system (CNS), ranging from neuroprotection to reduction of neuroinflammation. However, the neurogenic and oligodendrogenic potential of FTY720 has been poorly investigated. In this study, we assessed the effect of FTY720 on the production of new neurons and oligodendrocytes from neural stem/precursor cells both in vitro and in vivo...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28738820/omega-3-polyunsaturated-fatty-acid-supplementation-attenuates-microglial-induced-inflammation-by-inhibiting-the-hmgb1-tlr4-nf-%C3%AE%C2%BAb-pathway-following-experimental-traumatic-brain-injury
#8
Xiangrong Chen, Shukai Wu, Chunnuan Chen, Baoyuan Xie, Zhongning Fang, Weipeng Hu, Junyan Chen, Huangde Fu, Hefan He
BACKGROUND: Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs) to activate downstream signaling pathways, such as the nuclear factor (NF)-κB signaling pathway, leading to a cascade amplification of inflammatory responses, which are related to neuronal damage after TBI...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28738770/effects-of-resveratrol-and-other-polyphenols-on-the-most-common-brain-age-related-diseases
#9
Fiorella Sarubbo, David Moranta, Victor Jose Asensio, Antonio Miralles, Susana Esteban
With the global increase in the elderly population, modern societies must meet the challenge to find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Over the last two decades, oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. As a suggested treatment, the consumption or administration of antioxidant and anti-inflammatory molecules, such as polyphenols, present in food, is recommended as a beneficial strategy for preventing brain aging and several brain age-related diseases...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28738764/neuroprotection-by-endo-cannabinoids-in-glaucoma-and-retinal-neurodegenerative-diseases
#10
Cinzia Rapino, Daniel Tortolani, Lucia Scipioni, Mauro Maccarrone
Emerging neuroprotective strategies are being explored to preserve the retina from degeneration, that occurs in eye pathologies like glaucoma, diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa. Incidentally, neuroprotection of retina is a defending mechanism designed to prevent or delay neuronal cell death, and to maintain neural function following an initial insult, thus avoiding loss of vision. Numerous studies have investigated potential neuroprotective properties of plant-derived phytocannabinoids, as well as of their endogenous counterparts collectively termed endocannabinoids (eCBs), in several degenerative diseases of the retina...
July 24, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28738762/effects-of-neuroserpin-on-clinical-outcomes-and-inflammatory-markers-in-chinese-patients-with-acute-ischemic-stroke
#11
Weiwen Wu, Tetsuya Asakawa, Qianghong Yang, Jun Zhao, Lixia Lu, Yunhe Luo, Ping Gong, Sha Han, Wei Li, Hiroki Namba, Liang Wang
OBJECTIVE: Neuroserpin (NSP) is known for its neuroprotective effects. The aim of this study was to investigate the relationship between NSP level and clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. METHODS: A total of 133 patients with acute cerebral infarction (ischemia group) and 44 controls were recruited. The modified Rankin Scale (mRS) was used to determine the functional outcome three months after onset. We investigated the relationship between serum NSP levels [on admission and a decrease in NSP levels (10 days after admission versus on admission)] and serum levels of several inflammatory markers...
July 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28738538/diosmin-improved-cognitive-deficit-and-amplified-brain-electrical-activity-in-the-rat-model-of-traumatic-brain-injury
#12
Mohammad Ali Mirshekar, Hamed Fanaei, Fereshteh Keikhaei, Fatemeh Sargolzaee Javan
OBJECTIVE: Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities in humans. Clinically, it is essential to limit the progress of cognitive impairment after TBI. It is reported that diosmin has a neuroprotective effect that can limit the progress of the impairment. The aim of this study was to evaluate the effects of diosmin on neurological score, memory, tumor necrosis factor-α (TNF-α) level and long-term potentiation in hippocampal dentate gyrus after the injury...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738537/phosphodiesterase-inhibitor-ameliorates-neuronal-injury-in-spinal-cord-ischemia-reperfusion-injured-rat-model
#13
Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Yong-Yi Xu, Hai-Tao Yue
This study investigated the mechanisms responsible for the neuroprotective effect of sildenafil citrate (SFC) on ischemia-reperfusion spinal cord (SC) injuries. Balloon occlusion of the thoracic aorta was used to induce SC ischemia. The animals (n=30) were separated into three groups: sham, SC injury with saline, and SC injury with 5mg/kg i.p. SFC treatment (SFC). The Basso, Beattie, and Bresnahan (BBB) score was determined to assess neurological function at different time intervals after reperfusion. After 48h, histopathology of the SC was assessed by triphenyltetrazolium chloride (TTC) and Nissl staining...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738418/molecular-pathway-to-protection-from-age-dependent-photoreceptor-degeneration-in-mef2-deficiency
#14
Saumya Nagar, Dorit Trudler, Scott R McKercher, Juan Piña-Crespo, Nobuki Nakanishi, Shu-Ichi Okamoto, Stuart A Lipton
Purpose: Photoreceptor degeneration in the retina is a major cause of blindness in humans. Elucidating mechanisms of degenerative and neuroprotective pathways in photoreceptors should afford identification and development of therapeutic strategies. Methods: We used mouse genetic models and improved methods for retinal explant cultures. Retinas were enucleated from Mef2d+/+ and Mef2d-/- mice, stained for MEF2 proteins and outer nuclear layer thickness, and assayed for apoptotic cells...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738379/neurodegeneration-neuroregeneration-and-neuroprotection-in-psychiatric-disorders
#15
Siu W Tang, Daiga M Helmeste, Brian E Leonard
Prevention of deterioration of brain function over time is important in the long-term management of chronic brain disorders such as dementia, schizophrenia, and mood disorders. Although the possibility of neurogenesis in the adult human brain is attractive, and there are psychiatric drugs proven to be effective inducers of neurogenesis in animals, we have yet to see their utility in clinical practice. The terms neurodegeneration and neuroregeneration are often used in a nonspecific manner. Neuroregeneration may mean neurogenesis, dendritogenesis, spinogenesis, or axonogenesis...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738324/the-link-between-refractoriness-and-neuroprogression-in-treatment-resistant-bipolar-disorder
#16
Isabelle E Bauer, Jair C Soares, Salih Selek, Thomas D Meyer
Treatment refractoriness remains one of the biggest challenges in the field of bipolar disorder (BD) as treatments are often suboptimal or unsatisfactory. Recent evidence points towards a potential link between the progressively evolving nature of BD, increased inflammation, and reduced treatment response. There are several medications and other somatic treatments available, but remission rates are low, and medication compliance is still problematic. Psychotherapeutic techniques appear to be promising in several disease states and in relapse prevention, but additional research is needed to determine who will benefit from what strategy the most...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738100/multiple-neurotoxic-effects-of-haloperidol-resulting-in-neuronal-death
#17
Henry A Nasrallah, Alexander T Chen
BACKGROUND: Several published studies have reported an association between antipsychotic medications, especially first-generation agents, and a decline in gray matter volume. This prompted us to review the possible neurotoxic mechanisms of first-generation antipsychotics (FGAs), especially haloperidol, which has been widely used over the past several decades. METHODS: A PubMed search was conducted using the keywords haloperidol, antipsychotic, neurotoxicity, apoptosis, oxidative stress, and neuroplasticity...
August 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28737731/study-on-chemical-profile-and-neuroprotective-activity-of-myrica-rubra-leaf-extract
#18
Pinghong Chen, Xianzong Lin, Ching-Hsu Yang, Xu Tang, Yu-Wei Chang, Weibing Zheng, Lianzhong Luo, Changan Xu, Yung-Husan Chen
The chemical profile of Myrica rubra (a native species in China) leaf extract was investigated by UPLC-PDA-HRMS, and the neuroprotective activity of two characteristic constituents, myricanol and myricetrin, was evaluated with N2a cells using H₂O₂-inducedoxidative challenge through a series of methods, e.g., MTT assay, ROS assay and [Ca(2+)]i assay. Among the 188 constituents detected in the extract of Myrica rubra leaf, 116 were identified definitely or tentatively by the comprehensive utilization of precise molecular weight and abundant multistage fragmentation information obtained by quadrupole orbitrap mass spectrometry...
July 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28736294/enhanced-neuroprotection-of-anthocyanin-loaded-peg-gold-nanoparticles-against-a%C3%AE-1-42-induced-neuroinflammation-and-neurodegeneration-via-the-nf-kb-jnk-gsk3%C3%AE-signaling-pathway
#19
Min Ju Kim, Shafiq Ur Rehman, Faiz Ul Amin, Myeong Ok Kim
Amyloid-beta (Aβ1-42) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in Aβ1-42-injected mouse and in vitro models of AD...
July 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28736242/suppression-of-cortical-trpm7-protein-attenuates-oxidative-damage-after-traumatic-brain-injury-via-akt-endothelial-nitric-oxide-synthase-pathway
#20
Hong-Liang Xu, Meng-Dong Liu, Xiao-Hong Yuan, Chun-Xi Liu
Neuronal death after traumatic brain injury (TBI) is a complex process resulting from a combination of factors, many of which are still unknown. Transient receptor potential melastatin 7 (TRPM7) is a transient receptor potential channel that has been demonstrated to mediate ischemic and traumatic neuronal injury in vitro. In the present study, TRPM7 was suppressed in the rat cerebral cortex by intracortical injections of viral vectors bearing shRNA specific for TRPM7 to investigate its potential role in an in vivo TBI model...
July 20, 2017: Neurochemistry International
keyword
keyword
50100
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"