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https://www.readbyqxmd.com/read/28343053/self-reported-graphic-personal-and-social-performance-scale-srg-psp-for-measuring-functionality-in-patients-with-bipolar-disorder
#1
Ya Mei Bai, Cheng-Ta Li, Mu-Hong Chen, Yen Kuang Yang
OBJECTIVES: The self-reported graphic version of the Personal and Social Performance Scale (SRG-PSP) is the first graphic, self-reported rating scale that assesses functioning, and its reliability and validity have been documented in patients with schizophrenia. This study investigated the validity of SRG-PSP in patients with bipolar disorder (BD). METHODS: Patients with BD were recruited from psychiatric outpatient clinics, and assessed with the Young Mania Rating Scale (YMRS), the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impression Scale (CGI)-Bipolar and CGI-Depression, the Positive and Negative Symptom Scale (PANSS), the Global assessment of function (GAF), and the PSP...
February 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28343051/tolerability-of-cariprazine-in-the-treatment-of-acute-bipolar-i-mania-a-pooled-post-hoc-analysis-of-3-phase-ii-iii-studies
#2
Willie Earley, Suresh Durgam, Kaifeng Lu, Marc Debelle, István Laszlovszky, Eduard Vieta, Lakshmi N Yatham
BACKGROUND: Atypical antipsychotics have broad-spectrum efficacy against core symptoms of acute mania/mixed states in bipolar disorder; however, they are associated with clinically significant adverse effects (AEs). METHODS: This post hoc analysis evaluated the safety and tolerability of the atypical antipsychotic cariprazine in the treatment of adult patients with acute manic/mixed episodes of bipolar I disorder. Data were taken from three 3-week randomized, double-blind, placebo-controlled, flexible-dose trials of cariprazine 3-12mg/d...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28341618/can-gaming-increase-antibiotic-awareness-in-children-a-mixed-methods-approach
#3
Alexander R Hale, Vicki Louise Young, Ann Grand, Cliodna Ann Miriam McNulty
BACKGROUND: e-Bug is a pan-European educational resource for junior and senior school children, which contains activities covering prudent antibiotic use and the spread, treatment, and prevention of infection. Teaching resources for children aged 7-15 years are complemented by a student website that hosts games and interactive activities for the children to continue their learning at home. OBJECTIVE: The aim of this study was to appraise young people's opinions of 3 antibiotic games on the e-Bug student website, exploring children's views and suggestions for improvements, and analyzing change in their knowledge around the learning outcomes covered...
March 24, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28339282/melatonin-for-reducing-weight-gain-following-administration-of-atypical-antipsychotic-olanzapine-for-adolescents-with-bipolar-disorder-a-randomized-double-blind-placebo-controlled-trial
#4
Seyed-Ali Mostafavi, Mahmoud Solhi, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: We aimed to evaluate melatonin effectiveness in weight gain reduction following olanzapine use for 11-17-year-old bipolar disorder patients. EXPERIMENTAL DESIGN: Seventy-seven adolescent outpatients, subsequent to their initial diagnosis of bipolar I disorder by a psychiatrist, entered this study. After assessing inclusion and exclusion criteria, 48 patients consented to participate. Twenty-four patients were allocated to receive olanzapine, lithium carbonate, and melatonin, and 24 patients were allocated to receive olanzapine, lithium carbonate, and placebo by simple randomization...
March 24, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28338967/thought-disorder-in-schizophrenia-and-bipolar-disorder-probands-their-relatives-and-nonpsychiatric-controls
#5
Charity J Morgan, Michael J Coleman, Ayse Ulgen, Lenore Boling, Jonathan O Cole, Frederick V Johnson, Jan Lerbinger, J Alexander Bodkin, Philip S Holzman, Deborah L Levy
Thought disorder (TD) has long been associated with schizophrenia (SZ) and is now widely recognized as a symptom of mania and other psychotic disorders as well. Previous studies have suggested that the TD found in the clinically unaffected relatives of SZ, schizoaffective and bipolar probands is qualitatively similar to that found in the probands themselves. Here, we examine which quantitative measures of TD optimize the distinction between patients with diagnoses of SZ and bipolar disorder with psychotic features (BP) from nonpsychiatric controls (NC) and from each other...
March 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28338785/elevated-nucleus-accumbens-structural-connectivity-associated-with-proneness-to-hypomania-a-reward-hypersensitivity-perspective
#6
Katherine S Damme, Christina B Young, Robin Nusslock
The Reward Hypersensitivity Model of bipolar disorder argues that hypersensitivity to reward-relevant cues characterizes risk for hypo/mania. This hypersensitivity leads to increased goal-directed motivation during reward-relevant life events that, in the extreme, is reflected in hypo/manic symptoms. In line with this perspective, individuals with bipolar disorder display elevated activation in a cortico-striatal reward circuit including the nucleus accumbens (NAcc) and medial orbitofrontal cortex (mOFC). To date, however, research on reward-related neural circuitry underlying bipolar symptoms focuses on syndromal bipolar disorder (bipolar I, bipolar II), and typically examines neural regions in isolation of each other...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28338546/a-double-blind-placebo-controlled-pilot-study-of-riluzole-monotherapy-for-acute-bipolar-depression
#7
Lawrence T Park, Marc S Lener, Matthew Hopkins, Nicolas Iadorola, Rodrigo Machado-Vieira, Elizabeth Ballard, Allison Nugent, Carlos A Zarate
BACKGROUND: Glutamatergic system abnormalities are implicated in the pathophysiology and treatment of both major depressive disorder and bipolar depression (BDep). Subsequent to studies demonstrating the rapid and robust antidepressant effects of ketamine, an N-methyl-D-aspartate receptor antagonist, other glutamatergic modulators are now being studied in clinical trials of mood disorders. A previous open-label study found that riluzole, administered in combination with the mood stabilizer lithium, had antidepressant effects...
March 23, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28337866/fibromyalgia-and-bipolar-disorder-extent-of-comorbidity-and-therapeutic-implications
#8
M C Di Tommaso Morrison, F Carinci, G Lessiani, E Spinas, S K Kritas, G Ronconi, Al Caraffa, P Conti
Fibromyalgia (FM) is a syndrome that affects muscles and soft tissues. Presenting symptoms include chronic muscle pain, fatigue, sleep problems and psychological symptoms, including depression and anxiety. There exists strong evidence of a comorbidity between FM and Bipolar Disorder (BD). In this study, papers from 2006 to February 2016 that examined the comorbidity and etiological similarities of FM and BD were reviewed, as well as the therapeutic implications of these findings. The reviewed articles showed that an adequate psychiatric screening for BD is recommended in FM patients with depressive symptoms, in order to decrease administration of antidepressants for BD, due to the lack of proven efficacy, and to limit antidepressant-induced mania...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#9
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28331865/growth-hormone-utilization-review-in-a-pediatric-primary-care-setting
#10
Fatemeh Sayarifard, Fereshteh Bakhshi Imcheh, Shirinsadat Badri, Toktam Faghihi, Mostafa Qorbani, Mania Radfar
OBJECTIVE: One of the main problems facing public health providers and administrators in many countries is ensuring the rational use of high-cost drugs. In this regard, on-going process of medication use evaluation can be considered as a useful tool. In this study, we evaluated certain usage aspects of a highly-cost medication, that is, recombinant growth hormone (GH). METHODS: This cross-sectional study conducted from August 2012 to August 2014. Children receiving GH ± gonadotropin releasing hormone (GnRH) analogs were included in the study...
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28331326/lithium-in-late-life-mania-a-systematic-review
#11
REVIEW
Pasquale De Fazio, Raffaele Gaetano, Mariarita Caroleo, Maria Pavia, Giovanbattista De Sarro, Andrea Fagiolini, Cristina Segura-Garcia
The prevalence of mania among >65-year-olds ranges from 0.1% to 0.4% and its treatment is a particular challenge for clinicians. Although lithium is the treatment of choice for bipolar disorder (BD), its use in elderly population was recently questioned. This study provides a comprehensive review of literature on the efficacy and tolerability of lithium as a pharmacologic treatment for mania in elderly BD patients. We conducted a systematic review, based on PRISMA guidelines, of articles published between 1970 and August 2016 and indexed in the following databases: EMBASE, MEDLINE, Cochrane Library Databases and PsycINFO...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28328964/the-acute-mania-of-king-george-iii-a-computational-linguistic-analysis
#12
Vassiliki Rentoumi, Timothy Peters, Jonathan Conlin, Peter Garrard
We used a computational linguistic approach, exploiting machine learning techniques, to examine the letters written by King George III during mentally healthy and apparently mentally ill periods of his life. The aims of the study were: first, to establish the existence of alterations in the King's written language at the onset of his first manic episode; and secondly to identify salient sources of variation contributing to the changes. Effects on language were sought in two control conditions (politically stressful vs...
2017: PloS One
https://www.readbyqxmd.com/read/28327444/unblending-borderline-personality-and-bipolar-disorders
#13
Ester di Giacomo, Flora Aspesi, Maria Fotiadou, Arnoud Arntz, Eugenio Aguglia, Lavinia Barone, Silvio Bellino, Bernardo Carpiniello, Fabrizia Colmegna, Marina Lazzari, Liliana Lorettu, Federica Pinna, Aldo Sicaro, Maria Salvina Signorelli, Massimo Clerici
Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum. Opponents to this inclusion attribute the important differences and possible diagnostic incomprehension to overlapping symptoms. We tested 248 Borderline and 113 Bipolar patients, consecutively admitted to the Psychiatric Unit, through DSM-IV Axis I and II Disorders (SCID-I/II), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Young Mania Rating Scale (YMRS) and Borderline Personality Disorder Severity Index-IV (BPDSI-IV)...
March 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28300934/an-evolutionary-approach-to-mania-studying-sardinian-immigrants-to-argentina
#14
Mauro G Carta, Alessandra Perra, Michela Atzeni, Silvia D'Oca, Maria F Moro, Peter K Kurotschka, Daniela Moro, Federica Sancassiani, Luigi Minerba, Maria V Brasesco, Gustavo Mausel, Antonio E Nardi, Leonardo Tondo
Objective: To ascertain lifetime prevalence of positivity to a screening questionnaire for bipolar disorders (BD) in Sardinian immigrants to Argentina and residents of Sardinia and assess whether such positivity affects quality of life (QoL) in either group. Our hypothesis is that screen positivity for BD may be more frequent in immigrants. Methods: Observational study. Subjects were randomly selected from the membership lists of associations of Sardinian immigrants in Argentina...
March 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28300012/lurasidone-for-major-depressive-disorder-with-mixed-features-and-irritability-a-post-hoc-analysis
#15
Alan C Swann, Maurizio Fava, Joyce Tsai, Yongcai Mao, Andrei Pikalov, Antony Loebel
OBJECTIVE: The aim of this post-hoc analysis was to evaluate the efficacy of lurasidone in treating major depressive disorder (MDD) with mixed features including irritability. METHODS: The data in this analysis were derived from a study of patients meeting DSM-IV-TR criteria for unipolar MDD, with a Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥26, presenting with two or three protocol-defined manic symptoms, and who were randomized to 6 weeks of double-blind treatment with either lurasidone 20-60 mg/d (n=109) or placebo (n=100)...
March 16, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28294710/behavioral-disconnection-syndrome-manifesting-as-combined-mania-and-visual-auditory-hallucinations-secondary-to-isolated-right-thalamic-hemorrhage
#16
Parunyou Julayanont, Doungporn Ruthirago, Khondoker Alam, Yazan J Alderazi
No abstract text is available yet for this article.
March 15, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28291299/-neurosyphilis-in-psychiatric-settings-three-case-reports
#17
Erhan Akıncı, Fatih Öncü, Barış Topçular
Syphilis is a generally sexually transmitted and multisystem disease caused by the spirochete Treponema pallidum. All of the organs of the body may be involved during the course of the disease. Neurosyphilis is a clinical form of syphilis with the central nervous system (CNS) involvement. While primarily meningeal and vascular structures are involved in early neurosyphilis, a parenchymal affection of the brain and spinal cord emerges at later stages of neurosyphilis. It presents with symptoms of meningitis, meningovasculitis and parenchymal neurosyphilis (presenting as tabes dorsalis and general paresis)...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28291043/repetitive-transcranial-magnetic-stimulation-and-treatment-emergent-mania-and-hypomania-a-review-of-the-literature
#18
Fady Rachid
BACKGROUND: This review focuses on treatment-emergent mania/hypomania (TEM) associated with repetitive transcranial magnetic stimulation (rTMS). METHODS: English-language studies involving possible rTMS-induced mania/hypomania published between 1966 and 2015 were retrieved through a Medline search using the search terms mania, hypomania, mixed affective state, treatment-emergent, repetitive transcranial magnetic stimulation, and rTMS. Fifteen case series and controlled studies describing TEM associated with rTMS treatment have been published involving 24 individuals, most of whom were diagnosed with either bipolar I or II disorder or major depressive disorder...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28289283/the-dopamine-hypothesis-of-bipolar-affective-disorder-the-state-of-the-art-and-implications-for-treatment
#19
REVIEW
A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howes
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use of antidopaminergics in the treatment of this disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theory. To do this, we conducted a systematic search for post-mortem, pharmacological, functional magnetic resonance and molecular imaging studies of dopamine function in bipolar disorder...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28288308/the-link-between-hypomania-risk-and-creativity-the-role-of-heightened-behavioral-activation-system-bas-sensitivity
#20
Bin-Na Kim, Seok-Man Kwon
BACKGROUND: The relationship between bipolar disorder (BD) and creativity is well-known; however, relatively little is known about its potential mechanism. We investigated whether heightened behavioral activation system (BAS) sensitivity may mediate such relationship. METHODS: Korean young adults (N=543) completed self-report questionnaires that included the Hypomanic Personality Scale (HPS), the Behavioral Activation System(BAS) Scale, the Everyday Creativity Scale (ECS), the Positive Affect and Negative Affect Schedule (PANAS), and the Altman Self-Rating Mania Scale (ASRM)...
March 2, 2017: Journal of Affective Disorders
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