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https://www.readbyqxmd.com/read/28806578/klotho-dysfunction-a-pathway-linking-the-aging-process-to-bipolar-disorder
#1
Izabela Guimarães Barbosa, Natalia Pessoa Rocha, Gokay Alpak, Erica Leandro Marciano Vieira, Rodrigo Barreto Huguet, Fabio Lopes Rocha, Breno Satler de Oliveira Diniz, Antonio Lucio Teixeira
AIM: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls. METHODS: Forty patients with type 1 BD and 30 controls were enrolled in this study...
August 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28804990/characterizing-the-experience-of-auditory-verbal-hallucinations-and-accompanying-delusions-in-individuals-with-a-diagnosis-of-bipolar-disorder-a-systematic-review
#2
REVIEW
L M Smith, L C Johns, Rlc Mitchell
OBJECTIVES: The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psychotic symptoms. METHODS: A comprehensive synthesis of findings on the phenomenology of AVH and delusions in BD is included, alongside a critical review of clinical and cognitive correlates...
August 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28803094/brief-psychoeducation-for-bipolar-disorder-evaluation-of-trophic-factors-serum-levels-in-young-adults
#3
Carolina David Wiener, Mariane Lopez Molina, Fernanda Pedrotti Moreira, Miguel Bezerra Dos Passos, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Jean Pierre Oses
The aim of this study was to evaluate the impact of psychoeducation in serum levels of BDNF, NGF and GDNF in young adults presenting bipolar disorder (BD). This is a randomized clinical trial including 39 young adults (18-29 years) diagnosed with BD through the Structured Clinical Interview for DSM-IV (SCID-CV). Participants were randomized in two treatment groups: usual treatment (medication) and combined intervention (medication plus psychoeducation). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and severity of manic and hypomanic symptoms was evaluated through the Young Mania Rating Scale (YMRS)...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28802190/alcohol-use-and-bipolar-disorders-risk-factors-associated-with-their-co-occurrence-and-sequence-of-onsets
#4
Jean-Michel Azorin, Léa C Perret, Eric Fakra, Sébastien Tassy, Nicolas Simon, Marc Adida, Raoul Belzeaux
BACKGROUND: Little is known about the sequence of onsets in patients affected by comorbid alcohol use and bipolar disorder. This study examines the risk factors associated with their co-occurrence and order of onset. METHOD: The demographic, clinical, and temperament characteristics as well as the course of illness were analyzed within our sample of 1090 DSM-IV bipolar I manic patients. Our sample was categorized according to the presence of comorbid alcohol use disorder and the sequence of onsets of bipolar and alcohol use disorders i...
August 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28801671/the-cpg-sites-of-the-cbx3-ubiquitous-chromatin-opening-element-are-critical-structural-determinants-for-the-anti-silencing-function
#5
Jessica Kunkiel, Natascha Gödecke, Mania Ackermann, Dirk Hoffmann, Axel Schambach, Nico Lachmann, Dagmar Wirth, Thomas Moritz
Suppression of therapeutic transgene expression from retroviral gene therapy vectors by epigenetic defence mechanisms represents a problem that is particularly encountered in pluripotent stem cells (PSCs) and their differentiated progeny. Transgene expression in these cells, however, can be stabilised by CpG-rich ubiquitous chromatin opening elements (UCOEs). In this context we recently demonstrated profound anti-silencing properties for the small (679 bp) CBX3-UCO element and we now confirmed this observation in the context of the defined murine chromosomal loci ROSA26 and TIGRE...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800706/parsing-the-hypomanic-personality-explicating-the-nature-of-specific-dimensions-defining-mania-risk
#6
Kasey Stanton, Daniel B McArtor, David Watson
Considerable research has used the Hypomanic Personality Scale (HPS) to assess traits conferring risk for hypomanic and manic episodes. Although the HPS has been shown to be defined by several distinct sets of content, most research has continued to rely exclusively on HPS total scores, due to (a) little research having examined its structure and (b) the discrepant structural results obtained in the few available studies. Therefore, we examined the structure and relations of the HPS in a large sample of community adults ( N = 737) receiving psychiatric treatment...
August 1, 2017: Assessment
https://www.readbyqxmd.com/read/28799261/serum-osmolarity-in-male-patients-with-bipolar-disorder-manic-episode
#7
Tevfik Kalelioglu, Nesrin Karamustafalioglu, Abdullah Genc, Murat Kocabiyik
Imbalance of water and electrolyte homeostasis has been suggested to be associated with the acute episodes of bipolar disorder. In this study we aimed to investigate, for the first time, the serum osmolarity in bipolar disorder manic episode. A total of 68 bipolar inpatients in manic episode and 60 age-gender matched healthy controls were included in the study. Serum osmolarity was calculated from Sodium (Na(+) ), glucose and blood urea nitrogen (BUN) according to formula of (2 × Na(+) ) + (BUN/2.8) + (Glucose/18)...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28797561/self-reported-psychosis-like-experiences-in-patients-with-mood-disorders
#8
I Baryshnikov, J Suvisaari, K Aaltonen, M Koivisto, T Melartin, P Näätänen, K Suominen, B Karpov, M Heikkinen, J Oksanen, T Paunio, G Joffe, E Isometsä
BACKGROUND: Self-reported psychosis-like experiences (PEs) may be common in patients with mood disorders, but their clinical correlates are not well known. We investigated their prevalence and relationships with self-reported symptoms of depression, mania, anxiety, borderline (BPD) and schizotypal (SPD) personality disorders among psychiatric patients with mood disorders. METHODS: The Community Assessment of Psychic Experiences (CAPE-42), Mood Disorder Questionnaire (MDQ), McLean Screening Instrument (MSI), The Beck Depressive Inventory (BDI), Overall Anxiety Severity and Impairment Scale (OASIS) and Schizotypal Personality Questionnaire-Brief form (SPQ-B) were filled in by patients with mood disorders (n=282) from specialized care...
February 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28783937/plasma-levels-of-tumor-necrosis-factor-superfamily-molecules-are-increased-in-bipolar-disorder
#9
Izabela G Barbosa, Gabriela Neves Vaz, Natalia Pessoa Rocha, Rodrigo Machado-Vieira, Marcio Rogerio Diniz Ventura, Rodrigo B Huguet, Moises E Bauer, Michael Berk, Antônio L Teixeira
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28783519/antimanic-activity-of-minocycline-in-a-gbr12909-induced-model-of-mania-in-mice-possible-role-of-antioxidant-and-neurotrophic-mechanisms
#10
Ana Isabelle G de Queiroz, Adriano José Maia Chaves Filho, Tatiane da Silva Araújo, Camila Nayane Carvalho Lima, Michel de Jesus Souza Machado, André F Carvalho, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, João Quevedo, Danielle Macedo
BACKGROUND: Mania/hypomania is the cardinal feature of bipolar disorder. Recently, single administration of the dopamine transporter (DAT) inhibitor, GBR12909, was related to mania-like alterations. In the present study we aimed at testing behavioral and brain oxidant/neurotrophic alterations induced by the repeated administration of GBR12909 and its prevention/reversal by the mood stabilizing drugs, lithium (Li) and valproate (VAL) as well as by the neuroprotective drug, minocycline (Mino)...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28780783/implications-of-circadian-rhythm-in-dopamine-and-mood-regulation
#11
REVIEW
Jeongah Kim, Sangwon Jang, Han Kyoung Choe, Sooyoung Chung, Gi Hoon Son, Kyungjin Kim
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm...
July 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28780293/progress-in-life-s-history-linking-darwinism-and-palaeontology-in-britain-1860-1914
#12
Chris Manias
This paper examines the tension between Darwinian evolution and palaeontological research in Britain in the 1860-1914 period, looking at how three key promoters of Darwinian thinking - Thomas Henry Huxley, Edwin Ray Lankester and Alfred Russell Wallace - integrated palaeontological ideas and narratives of life's history into their public presentations of evolutionary theory. It shows how engagement with palaeontological science was an important part of the promotion of evolutionary ideas in Britain, which often bolstered notions that evolution depended upon progress and development along a wider plan...
August 2, 2017: Studies in History and Philosophy of Biological and Biomedical Sciences
https://www.readbyqxmd.com/read/28780133/altered-glua1-gria1-function-and-accumbal-synaptic-plasticity-in-the-clock%C3%AE-19-model-of-bipolar-mania
#13
Puja K Parekh, Darius Becker-Krail, Poornima Sundaravelu, Shinsuke Ishigaki, Haruo Okado, Gen Sobue, Yanhua Huang, Colleen A McClung
BACKGROUND: Disruptions in circadian rhythms are associated with an increased risk for bipolar disorder. Moreover, studies show that the circadian protein CLOCK (circadian locomotor output cycles kaput) is involved in regulating monoaminergic systems and mood-related behavior. However, the molecular and synaptic mechanisms underlying this relationship remain poorly understood. METHODS: Using ex vivo whole-cell patch-clamp electrophysiology in ClockΔ19 mutant and wild-type mice we characterized alterations in excitatory synaptic transmission, strength, and intrinsic excitability of nucleus accumbens (NAc) neurons...
June 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28777984/comorbid-sleep-disorders-and-suicide-risk-among-children-and-adolescents-with-bipolar-disorder
#14
Ian H Stanley, Melanie A Hom, Joan L Luby, Paramjit T Joshi, Karen D Wagner, Graham J Emslie, John T Walkup, David A Axelson, Thomas E Joiner
Children and adolescents with bipolar disorder are at increased risk for suicide. Sleep disturbances are common among youth with bipolar disorder and are also independently implicated in suicide risk; thus, comorbid sleep disorders may amplify suicide risk in this clinical population. This study examined the effects of comorbid sleep disorders on suicide risk among youth with bipolar disorder. We conducted secondary analyses of baseline data from the Treatment of Early Age Mania (TEAM) study, a randomized controlled trial of individuals aged 6-15 years (mean ± SD = 10...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777983/vitamin-d-supplementation-in-bipolar-depression-a-double-blind-placebo-controlled-trial
#15
Wendy K Marsh, Jessica L Penny, Anthony J Rothschild
OBJECTIVE: Bipolar depression is difficult to treat. Vitamin D supplementation is well tolerated and may improve mood via its neurotransmitter synthesis regulation, nerve growth factor enhancement and antioxidant properties. Vitamin D adjunct reduces unipolar depression, but has not been tried in bipolar depression. METHODS: 18-70yos with DSM IV bipolar depression and Vitamin D deficiency (<30 ng/ml) were randomized in a controlled double blind trial of 5000IU Vitamin D3 po qday supplementation versus placebo for twelve weeks...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28777104/mood-stabilizing-effects-of-rapamycin-and-its-analog-temsirolimus-relevance-to-autophagy
#16
Nirit Z Kara, Shlomit Flaisher-Grinberg, Grant W Anderson, Galila Agam, Haim Einat
Accumulated data support a relationship between mood disorders and cellular plasticity and resilience, some suggesting relevance to autophagy. Our previous data show that pharmacological enhancement of autophagy results in antidepressant-like effects in mice. The current study was designed to further examine the effects of autophagy enhancement on mood by testing the effects of subchronic treatment with the mammalian target of rapamycin inhibitors and autophagy enhancers rapamycin and temsirolimus in a model for mania and in a model for antidepressant action, respectively...
August 2, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28769564/modeling-association-between-times-to-recurrence-of-the-different-polarities-in-bipolar-disorder-among-service-seekers-in-urban-nigeria-a-survival-analysis-approach
#17
Adeniyi Francis Fagbamigbe, Victor Adesola Makanjuola
INTRODUCTION: Bipolar disorder (BD) remains both a clinical and public health challenge worldwide, especially in developing countries such as Nigeria. Many studies have focused on prevalence and recurrences among BD service seekers but little has been documented on the nature, strength, direction, existence, and estimation of association between times to recurrence of the two possible polarities or mood episodes in BD. In this study, we explored the association between durations before recurrence of depression and manic episodes among people seeking treatment for BD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28768599/pre-onset-risk-characteristics-for-mania-among-young-people-at-clinical-high-risk-for-psychosis
#18
Aswin Ratheesh, Susan M Cotton, Christopher G Davey, Ashleigh Lin, Stephen Wood, Hok Pan Yuen, Andreas Bechdolf, Patrick D McGorry, Alison Yung, Michael Berk, Barnaby Nelson
INTRODUCTION: Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. METHODS: Among a cohort of 416 young people with an at-risk mental state for psychosis defined using the Ultra-High-Risk (UHR) criteria, 74...
May 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28766129/use-and-safety-of-antiepileptic-drugs-in-psychiatric-inpatients-data-from-the-amsp-study
#19
Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R Engel, Alexandra Kleimann, Susanne Stübner, Waldemar Greil, Sermin Toto
The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%...
August 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28761093/combined-serum-levels-of-multiple-proteins-in-tpa-bdnf-pathway-may-aid-the-diagnosis-of-five-mental-disorders
#20
Suzhen Chen, Haitang Jiang, Yang Liu, Zhenhua Hou, Yingying Yue, Yuqun Zhang, Fuying Zhao, Zhi Xu, Yinghui Li, Xiaodong Mou, Lei Li, Tianyu Wang, Jingjing Zhao, Chongyang Han, Yuxiu Sui, Ming Wang, Zhong Yang, Yan Lu, Yifeng Zhu, Jianhua Li, Xinhua Shen, Fei Sun, Qingsong Chen, Huanxin Chen, Yonggui Yuan
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits...
July 31, 2017: Scientific Reports
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