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https://www.readbyqxmd.com/read/29148147/altered-n170-and-mood-symptoms-in-bipolar-disorder-an-electrophysiological-study-of-configural-face-processing
#1
Ivy F Tso, Tyler B Grove, Savanna A Mueller, Lisa O'Donnell, Jinsoo Chun, Melvin G McInnis, Patricia J Deldin
OBJECTIVES: Altered social behavior during mood episodes in bipolar disorder often has detrimental and long-lasting interpersonal consequences. Abnormal face processing may play a role in linking brain functions to clinical symptoms and behavior. This study aimed to understand configural face processing in bipolar disorder as a function of basic communicative attributes of the face and mood symptoms using event-related brain potentials (ERPs). METHODS: Forty-two participants with bipolar I disorder (BP) and 43 healthy controls (HC) viewed face stimuli varying in emotion (neutral or fearful), head orientation (forward or deviated), and gaze direction (direct or averted) while ERPs were recorded...
November 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29146409/safety-and-effectiveness-of-long-term-treatment-with-lurasidone-in-older-adults-with-bipolar-depression-post-hoc-analysis-of-a-6-month-open-label-study
#2
Brent P Forester, Martha Sajatovic, Joyce Tsai, Andrei Pikalov, Josephine Cucchiaro, Antony Loebel
OBJECTIVE: To evaluate the safety and effectiveness of 6 months of treatment with lurasidone in older adults with a diagnosis of bipolar I depression. DESIGN: Post-hoc analysis of a multicenter, 6-month, open-label extension study. SETTING: Outpatient. PARTICIPANTS: Patients aged 55 to 75 years with a DSM-IV-TR diagnosis of bipolar I depression who had completed 6 weeks of double-blind, placebo-controlled treatment with either lurasidone monotherapy (1 study) or adjunctive therapy with lithium or valproate (2 studies)...
October 10, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#3
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29145178/minor-hemisphere-major-syndromes
#4
Antonio Carota, Julien Bogousslavsky
A right "minor hemisphere" does not exist as the right hemisphere is dominant for awareness (nosognosia), spatial attention, emotional regulation, facial and voice expressions, visual recognition, and topographical orientation. Without the right hemisphere, the world would be flat, deprived of general and spatial attentions, pointing preferentially to the right side of the space, lacking visual experiences and emotions, exhibiting diminished awareness of the self and environment. Clinical-related syndromes of the right hemisphere are unilateral spatial neglect, object and face visual agnosia, the anosognosia for hemiparesis and/or hemianopia, misidentification syndromes, mania, and other obsessions for the food and the body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29142662/clinical-response-of-clozapine-as-a-treatment-for-delirious-mania
#5
Nabeel Wahid, Garwin Chin, Andia H Turner, Alexis Seegan
No abstract text is available yet for this article.
October 19, 2017: Mental Illness
https://www.readbyqxmd.com/read/29132553/dysregulation-of-glucose-metabolism-since-young-adulthood-increases-the-risk-of-cardiovascular-diseases-in-patients-with-bipolar-disorder
#6
Pao-Huan Chen, Yen-Kuang Lin, Chi-Kang Chang, Shuo-Ju Chiang, Shang-Ying Tsai
Aging patients with bipolar disorder (BD) are at a high risk of cardiovascular diseases (CVDs). However, few studies have directly examined the association between metabolic risks and CVDs in patients with BD across the lifespan. Therefore, the aim of this study was to determine lifetime metabolic risk factors for CVDs in patients with BD. We recruited BD-I patients who were more than 50 years old and had had at least one psychiatric hospitalization. Patients who had a cardiologist-confirmed CVD diagnosis (ICD-9 code 401-414) were assigned to the case group...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29132244/adipocytokines-and-ghrelin-level-of-bipolar-patients-from-manic-episode-to-euthymic-episode
#7
Özgür Korhan Tunçel, Gökhan Sarısoy, Birşen Bilgici, Ozan Pazvantoğlu, Eda Çetin, Ebru Kaynar Tunçel
PURPOSE: Obesity and metabolic syndrome (MeS) are more frequently observed in bipolar patients than the general population. This may result from the differences of adipocytokines and ghrelin levels in bipolar disorder. MATERIAL AND METHODS: We evaluated the leptin, adiponectin, resistin and ghrelin levels in bipolar patients (n = 30) in manic episode and in a control group (n = 30). After treatment, the same patients were evaluated again during the euthymic episode...
November 13, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29130014/a-case-of-probable-amisulpride-induced-mania-after-eight-months-of-therapy
#8
Prakash Thapa, Rajasee Sharma
Development of manic symptoms during treatment with atypical antipsychotics can be a troublesome side effect that has been described with most atypical antipsychotics. However, reports of amisulpride induced mania have been rare. Here, we report the case of an 18-year-old male patient diagnosed with schizophrenia, who developed manic symptoms while on treatment with amisulpride. While previous reports have described occurrence of mania within days to three months of treatment with amisulpride, we report a case where manic symptoms occurred after around eight months of therapy...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29128113/measurement-equivalence-of-the-bdsx-scale-with-young-and-older-adults-with-bipolar-disorder
#9
Norm O'Rourke, Yaacov G Bachner, Sarah L Canham, Andrew Sixsmith, Badas Study Team
Instruments developed for mental health research are commonly devised and validated with young adults only. However, the measurement properties of these scales may differ over the lifespan. For this study, we set out to demonstrate the psychometric equivalence of the BDSx scale with an international sample of young and older adults with bipolar disorder (BD). We independently replicated the 4-factor model of BDSx responses with young and older participants (M = 45.63, range 19-87 years of age); we then compared the psychometric properties between models...
October 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29123113/talen-mediated-functional-correction-of-human-ipsc-derived-macrophages-in-context-of-hereditary-pulmonary-alveolar-proteinosis
#10
Alexandra Kuhn, Mania Ackermann, Claudio Mussolino, Toni Cathomen, Nico Lachmann, Thomas Moritz
Hereditary pulmonary alveolar proteinosis (herPAP) constitutes a rare, life threatening lung disease characterized by the inability of alveolar macrophages to clear the alveolar airspaces from surfactant phospholipids. On a molecular level, the disorder is defined by a defect in the CSF2RA gene coding for the GM-CSF receptor alpha-chain (CD116). As therapeutic options are limited, we currently pursue a cell and gene therapy approach aiming for the intrapulmonary transplantation of gene-corrected macrophages derived from herPAP-specific induced pluripotent stem cells (herPAP-iPSC) employing transcriptional activator-like effector nucleases (TALENs)...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#11
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29120844/prevalence-and-clinical-demographic-correlates-of-hyperhomocysteinemia-in-inpatients-with-bipolar-disorder-in-a-han-chinese-population
#12
Shuang-Jiang Zhou, Li-Gang Zhang, Hong-Mei Chen, Ju-Yan Li, Ran Li, Xi-Mei Zhang, Ning Wang, Jair C Soares, Ryan M Cassidy, Yingjun Zheng, Yuping Ning, Shao-Li Wang, Jing-Xu Chen, Xiang-Yang Zhang
Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent in patients with bipolar disorder (BD), placing them at greater risk of cardiovascular disease and possibly serving as a disease biomarker. However, the correlation of HHcy with demographic or clinical parameters is not well known. In this study, we examined the prevalence of HHcy and its association with these parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) levels were determined in 198 BD inpatients and 84 healthy controls...
August 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29119668/global-improvement-with-cariprazine-in-the-treatment-of-bipolar-i-disorder-and-schizophrenia-a-pooled-post-hoc-analysis
#13
Suresh Durgam, Willie Earley, Kaifeng Lu, György Németh, István Laszlovszky, Stephen Volk, Robert E Litman
INTRODUCTION: Global rating scale measures are useful for assessing the clinical relevance of patient change. Cariprazine, a dopamine D3 and D2 receptor partial agonist, is FDA-approved for the adult treatment of acute manic/mixed episodes of bipolar I disorder and schizophrenia. Post hoc evaluations of Clinical Global Impressions-Severity (CGI-S) scores from the cariprazine pivotal trials in both indications were conducted. METHODS: Data from 3 bipolar mania and 3 schizophrenia trials were pooled by indication (bipolar disorder = 1033; schizophrenia = 1466)...
November 9, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29119253/higher-expression-of-inhibitory-cd158b-and-cd158e-nk-cell-receptor-and-age-predicts-treatment-response-in-children-with-chronic-hepatitis-c
#14
Anna Mania, Mariusz Kaczmarek, Paweł Kemnitz, Katarzyna Mazur-Melewska, Magdalena Figlerowicz, Jan Sikora, Wojciech Służewski, Jan Żeromski
Treatment with pegylated interferon-α and ribavirin (PEG-IFN/RBV) is the only choice for chronic hepatitis C (CHC) in children. Natural killer (NK) cells were described to play a vital role in CHC. The aim of this study was to analyze the expression of peripheral blood NK cell receptors in their relation to PEG-IFN/RBV treatment response. Study included 26 children with CHC-13 boys, age range 13.42 ± 3.28 years. Blood for biochemical, virological and cytometric testing was taken for evaluation prior to the antiviral treatment...
November 8, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29116617/nanoparticulated-polymeric-composites-enfolding-lithium-carbonate-as-brain-drug-in-persuading-depression-an-in-vivo-study
#15
A Anita Margret, V Violet Dhayabaran, A Ganesh Kumar
Lithium carbonate is considered an effective drug against mania and acts as a mood stabilizer. It is found that it enhances antidepressants targeting depression, consequently it is prone to have risk factors that leads to adverse effects. The study is devised in confronting depression under nanoscale by preparing nanocomposites which is a matrix of biopolymer chitosan that encapsulates lithium carbonate by ionic gelation method. This facilitates the drug delivery in a regulated manner targeting the therapeutic action with a limited dosage that lessens the side effects in the course of treatment...
November 7, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/29112195/face-and-predictive-validity-of-the-clock%C3%AE-19-mouse-as-an-animal-model-for-bipolar-disorder-a-systematic-review
#16
REVIEW
M Kristensen, A A Nierenberg, S D Østergaard
Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (ClockΔ19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and ClockΔ19...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29111043/investigation-of-an-elutable-n-propylphosphonic-acid-chitosan-derivative-composition-with-a-chitosan-matrix-prepared-from-carbonic-acid-solution
#17
Szymon Mania, Robert Tylingo, Ewa Augustin, Katarzyna Gucwa, Jakub Szwacki, Hanna Staroszczyk
Porous chitosan composites using CO2 dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity of the materials was in the range 55-77% and decreased with increasong amount of modified chitosan in materials...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29108803/factor-analysis-of-symptom-dimensions-psychotic-affective-and-obsessive-compulsive-symptoms-in-schizophrenia
#18
Sandeep Grover, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
AIM: To carryout factor analysis of symptom profile of patients with schizophrenia assessed by using positive and negative syndrome scale (PANSS), Calgary depression rating scale (CDSS), Young mania rating scale (YMRS) and YBOCS checklist. METHODOLOGY: 181 patients of schizophrenia were assessed on PANSS, CDSS, YMRS and YBOCS checklist. RESULTS: Factor analysis of PANSS yielded 3 factor structure (positive, negative, anxiety). When the items of CDSS were added to the PANSS items, total number of factors increased to 4 with depression emerging as a separate factor...
October 23, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29108524/clinical-predictors-of-conversion-to-bipolar-disorder-in-a-prospective-longitudinal-familial-high-risk-sample-focus-on-depressive-features
#19
Andrew Frankland, Gloria Roberts, Ellen Holmes-Preston, Tania Perich, Florence Levy, Rhoshel Lenroot, Dusan Hadzi-Pavlovic, Michael Breakspear, Philip B Mitchell
BACKGROUND: Identifying clinical features that predict conversion to bipolar disorder (BD) in those at high familial risk (HR) would assist in identifying a more focused population for early intervention. METHOD: In total 287 participants aged 12-30 (163 HR with a first-degree relative with BD and 124 controls (CONs)) were followed annually for a median of 5 years. We used the baseline presence of DSM-IV depressive, anxiety, behavioural and substance use disorders, as well as a constellation of specific depressive symptoms (as identified by the Probabilistic Approach to Bipolar Depression) to predict the subsequent development of hypo/manic episodes...
November 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29105003/anxiety-irritability-and-agitation-as-indicators-of-bipolar-mania-with-depressive-symptoms-a-post-hoc-analysis-of-two-clinical-trials
#20
Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H Young, Roger S McIntyre
BACKGROUND: Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identification of this more severe form of BD-I. Using data from two clinical trials, the aims of this post hoc analysis were to describe the phenomenology of bipolar mania in terms of AIA and depressive symptoms, and to evaluate the influence of these symptoms on the likelihood of remission during treatment...
November 6, 2017: International Journal of Bipolar Disorders
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