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https://www.readbyqxmd.com/read/29329056/subjective-and-objective-sleep-discrepancy-in-symptomatic-bipolar-disorder-compared-to-healthy-controls
#1
Venkatesh Krishnamurthy, Dahlia Mukherjee, Aubrey Reider, Scott Seaman, Gagan Singh, Julio Fernandez-Mendoza, Erika Saunders
BACKGROUND: Bipolar disorder (BD) is associated with sleep misperception. The objective of this study was to investigate the correlation between subjective and objective measures of sleep in persons with symptomatic bipolar disorder (BDS) compared to healthy controls (HC). METHODS: We studied 24 BDS and 30 HC subjects similar in age, race and sex. Subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI) and objective sleep with 7-days of actigraphy...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329041/thiol-disulphide-homeostasis-in-bipolar-disorder
#2
Gamze Erzin, Vahap Ozan Kotan, Canan Topçuoğlu, Güven Özkaya, Özcan Erel, Rabia Nazik Yüksel, Emre Ürer, Makbule Çiğdem Aydemir, Erol Göka
Bipolar disorder (BD) patients have increased oxidative stress, which can disturb thiol/disulphide homeostasis, causing disulphide formation. The aim of the study is to investigate dynamic thiol/disulphide (SH/SS) homeostasis in BD patients, which is a novel evaluation method of oxidative status. Ninety-four BD patients (50 in the manic episode and 44 in remission) and 44 healthy controls were included in the study. Blood serum native thiol (SH) and total thiol (ToSH) concentrations were measured in a paired test...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29327798/severity-of-symptoms-in-mania-clinical-guidelines-and-study-design-implications
#3
Mauricio Tohen
No abstract text is available yet for this article.
January 12, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29327701/distribution-of-killer-immunoglobulin-like-receptor-genes-in-hiv-infected-long-term-non-progressors-from-mumbai-india
#4
Vijay R Chavan, Zakiya Ansari, Preeti Mehta, Jayanti Mania-Pramanik
BACKGROUND: Few reports suggest the association of killer immunoglobulin-like receptors of natural killer cells with human immunodeficiency virus infection. India with world's third largest population of human immunodeficiency virus / acquired immunodeficiency syndrome, offers scope to study such association. OBJECTIVE: Current study (2010-2015) was designed to evaluate if killer immunoglobulin-like receptors gene polymorphisms are associated with HIV infection outcomes specifically, with long term non progressors...
January 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29325238/psychometrics-of-the-self-report-concise-associated-symptoms-tracking-scale-cast-sr-results-from-the-stride-ctn-0037-study
#5
Joseph M Trombello, Michael O Killian, Allen Liao, Katherine Sanchez, Tracy L Greer, Robrina Walker, Bruce Grannemann, Chad D Rethorst, Thomas Carmody, Madhukar H Trivedi
OBJECTIVE: The self-report Concise Associated Symptoms Tracking Scale (CAST-SR) was developed to track mania, irritability, anxiety, panic, and insomnia symptoms among depressed outpatients receiving antidepressant medication. Given the overlap between these domains, depression, and stimulant use disorders, we reexamined CAST-SR psychometrics in a novel sample: individuals with stimulant use disorder receiving aerobic exercise or health education interventions. METHODS: Using the subsample of stimulant-dependent (following DSM-IV criteria) individuals prescribed antidepressants (N = 124) from the multisite Stimulant Reduction Intervention Using Dosed Exercise (CTN-0037) trial (total sample N = 302), conducted July 2010 to February 2013, we analyzed CAST-SR data collected at the first assessment after participant's discharge from residential treatment...
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29310066/is-recurrence-in-major-depressive-disorder-related-to-bipolarity-and-mixed-features-results-from-the-bridge-ii-mix-study
#6
Lorenzo Mazzarini, Georgios D Kotzalidis, Daria Piacentino, Salvatore Rizzato, Jules Angst, Jean-Michel Azorin, Charles L Bowden, Sergey Mosolov, Allan H Young, Eduard Vieta, Paolo Girardi, Giulio Perugi
BACKGROUND: Current classifications separate Bipolar (BD) from Major Depressive Disorder (MDD) based on polarity rather than recurrence. We aimed to determine bipolar/mixed feature frequency in a large MDD multinational sample with (High-Rec) and without (Low-Rec) >3 recurrences, comparing the two subsamples. METHODS: We measured frequency of bipolarity/hypomanic features during current depressive episodes (MDEs) in 2347 MDD patients from the BRIDGE-II-mix database, comparing High-Rec with Low-Rec...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29309989/bipolar-disorder-and-related-mood-states-are-not-associated-with-endothelial-function-of-small-arteries-in-adults-without-heart-disease
#7
Brian Tong, Oluchi Abosi, Samantha Schmitz, Janie Myers, Gary L Pierce, Jess G Fiedorowicz
BACKGROUND: Individuals with bipolar disorder are at increased risk for adverse cardiovascular disease (CVD) events. This study aimed to assess endothelial function and wave reflection, a risk factor for CVD, as measured by finger plethysmography in bipolar disorder to investigate whether CVD risk was higher in bipolar disorder and altered during acute mood episodes. We hypothesized that EndoPAT would detect a lower reactive hyperemia index (RHI) and higher augmentation index (AIX) in individuals with bipolar disorder compared with controls...
December 19, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29309958/no-differences-in-manic-like-behaviors-between-voluntary-ethanol-and-water-drinking-in-lateral-hypothalamic-kindled-lhk-alcohol-preferring-rats
#8
Noha Abdel Gawad, Khalid Mohamed, Doo-Sup Choi, Osama A Abulseoud
This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors (p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29308715/exploring-the-relationship-between-vitamin-d-and-mania-correlations-between-serum-vitamin-d-levels-and-disease-activity
#9
Neslihan Altunsoy, Rabia Nazik Yüksel, Merve Cingi Yirun, Ayşegül Kılıçarslan, Çiğdem Aydemir
BACKGROUND: Several studies suggest an association between hypovitaminosis D and mood disorders including major depressive disorder, seasonal affective disorder and premenstrual dysphoric disorder. On the other hand, there is not enough study about acute manic episode and hypovitaminosis D. This data insufficient zone led us to study on whether vitamin D deficiency is associated with acute manic episode and has an impact on disease activity Methods: Thirty-one patients with bipolar disorder in remission, 26 patients with acute manic episode and 40 healthy controls with no major psychopathology were recruited in this study...
January 7, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29308332/topiramate-induced-lithium-toxicity
#10
Afaque H Khan, Shazia Q Shah
This case report discusses a suspected case of lithium toxicity following the administration of topiramate (TPM). Our patient is a 47-year-old man who has been an inpatient for the past year and was diagnosed with schizoaffective disorder bipolar type 1 for the past 20 years according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). He manifested symptoms of lithium toxicity following administration of TPM to ameliorate the compulsive consumption of food and liquids...
October 26, 2017: Curēus
https://www.readbyqxmd.com/read/29303955/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#11
David A Kahn
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29303954/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#12
John F Gottlieb
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29303919/efficacy-and-safety-of-intensive-transcranial-magnetic-stimulation
#13
Tomas Sverak, Libor Ustohal
Repetitive transcranial magnetic stimulation (rTMS) is customarily applied on a daily basis for prolonged periods of time for the treatment of psychiatric diseases. The process is demanding in terms of staff and patient time, and the onset of the effect is slow. Recently, intensive rTMS protocols have been introduced in which stimulation is applied to the same area more than once a day with a higher than standard number of pulses. This article reviews 16 articles to determine the safety and efficacy of such protocols...
January 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29303376/effects-of-interdisciplinary-collaboration-in-hospitals-on-medication-errors-an-integrative-review
#14
Elizabeth Manias
Medication errors are commonly affected by breakdowns in communication. Interdisciplinary collaboration is an important means of facilitating communication between health professionals in clinical practice. To date, there has been little systematic examination of past research in this area. Areas covered: The aims of this integrative review are to examine how interdisciplinary collaboration influences medication errors in hospitals, the araes of interdisciplinary collaboration that have been researched in previous work, and recommendations for future research and practice...
January 5, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29296734/gene-correction-of-hax1-reversed-kostmann-disease-phenotype-in-patient-specific-induced-pluripotent-stem-cells
#15
Erik Pittermann, Nico Lachmann, Glenn MacLean, Stephan Emmrich, Mania Ackermann, Gudrun Göhring, Brigitte Schlegelberger, Karl Welte, Axel Schambach, Dirk Heckl, Stuart H Orkin, Tobias Cantz, Jan-Henning Klusmann
Severe congenital neutropenia (SCN, Kostmann disease) is a heritable disorder characterized by a granulocytic maturation arrest. Biallelic mutations in HCLS1 associated protein X-1 (HAX1) are frequently detected in affected individuals, including those of the original pedigree described by Kostmann in 1956. To date, no faithful animal model has been established to study SCN mediated by HAX1 deficiency. Here we demonstrate defective neutrophilic differentiation and compensatory monocyte overproduction from patient-derived induced pluripotent stem cells (iPSCs) carrying the homozygous HAX1W44X nonsense mutation...
June 13, 2017: Blood Advances
https://www.readbyqxmd.com/read/29291581/analysis-on-speech-signal-features-of-manic-patients
#16
Jing Zhang, Zhongde Pan, Chao Gui, Ting Xue, Yezhe Lin, Jie Zhu, Donghong Cui
Given the lack of effective biological markers for early diagnosis of bipolar mania, and the tendency for voice fluctuation during transition between mood states, this study aimed to investigate the speech features of manic patients to identify a potential set of biomarkers for diagnosis of bipolar mania. 30 manic patients and 30 healthy controls were recruited and their corresponding speech features were collected during natural dialogue using the Automatic Voice Collecting System. Bech-Rafaelsdn Mania Rating Scale (BRMS) and Clinical impression rating scale (CGI) were used to assess illness...
December 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29289701/dopamine-transporter-knockdown-mice-in-the-behavioral-pattern-monitor-a-robust-reproducible-model-for-mania-relevant-behaviors
#17
Molly A Kwiatkowski, Gerhard Hellemann, Catherine A Sugar, Zackary A Cope, Arpi Minassian, William Perry, Mark A Geyer, Jared W Young
Efforts to replicate results from both basic and clinical models have highlighted problems with reproducibility in science. In psychiatry, reproducibility issues are compounded because the complex behavioral syndromes make many disorders challenging to model. We develop translatable tasks that quantitatively measure psychiatry-relevant behaviors across species. The behavioral pattern monitor (BPM) was designed to analyze exploratory behaviors, which are altered in patients with bipolar disorder (BD), especially during mania episodes...
December 28, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29286593/circadian-rhythm-sleep-wake-disorders-predict-shorter-time-to-relapse-of-mood-episodes-in-euthymic-patients-with-bipolar-disorder-a-prospective-48-week-study
#18
Yoshikazu Takaesu, Yuichi Inoue, Kotaro Ono, Akiko Murakoshi, Kunihiro Futenma, Yoko Komada, Takeshi Inoue
OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29284814/a-rare-presentation-of-a-case-of-obsessive-compulsive-disorder-comorbid-with-bipolar-affective-disorder
#19
Nimmy Chandran, Arpit Parmar, Koushik Sinha Deb
Obsessive-compulsive disorder (OCD) is a chronic illness with waxing and waning course. OCD is not uncommonly found to be comorbid with bipolar affective disorder (BPAD). The course and prognosis of OCD have distinctive features in such cases. Only rarely symptoms of OCD emerge during mania in such individuals. We hereby report a very unusual case of OCD comorbid with BPAD in which obsession and compulsion symptoms occurred only during manic episodes with complete remission during periods between manic episodes (including during depressive episodes)...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29283064/glycogen-synthase-kinase-3%C3%AE-as-a-putative-therapeutic-target-for-bipolar-disorder
#20
Manoj P Dandekar, Samira S Valvassori, Gustavo Colombo Dal-Pont, Joao L DeQuevedo
BACKGROUND: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent episodes of mania and depression. Primary mood-stabilizing drugs like lithium and valproate alleviate the hypomanic or mild to moderate manic episodes in patients with BD. One of the extensively studied underlying mechanisms for these pharmacological interventions is inhibition of intracellular signaling cascades associated with glycogen synthase kinase-3 beta (GSK-3β), a multi-functional serine-threonine kinase...
December 27, 2017: Current Drug Metabolism
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