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Seva G Khambadkone, Zachary A Cordner, Faith Dickerson, Emily G Severance, Emese Prandovszky, Mikhail Pletnikov, Jianchun Xiao, Ye Li, Gretha J Boersma, C Conover Talbot, Wayne W Campbell, Christian S Wright, C Evan Siple, Timothy H Moran, Kellie L Tamashiro, Robert H Yolken
Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3...
July 18, 2018: Molecular Psychiatry
G Kiekens, P Hasking, M Boyes, L Claes, P Mortier, R P Auerbach, P Cuijpers, K Demyttenaere, J G Green, R C Kessler, I Myin-Germeys, M K Nock, R Bruffaerts
BACKGROUND: Theoretical and empirical literature suggests that non-suicidal self-injury (NSSI) is an important correlate of suicide risk. The present study was designed to evaluate: (a) whether NSSI is associated with increased odds of subsequent onsets of suicidal thoughts and behaviors (STB) independent of common mental disorders, (b) whether NSSI is associated with increased risk of transitioning from suicide ideation to attempt, and (c) which NSSI characteristics are associated with STB after NSSI...
June 30, 2018: Journal of Affective Disorders
R Thompson, R Hornigold, L Page, T Waite
OBJECTIVES: The objective of this study was to describe the mental health effects of high ambient temperatures and heat waves, determine whether heat-related morbidity and mortality are increased among people with known mental disorders and identify knowledge gaps to inform targeting of future research. STUDY DESIGN: Systematic literature review and narrative synthesis. METHODS: A systematic review of published literature using MEDLINE, Embase and PsycINFO without geographical or temporal limits was conducted...
July 11, 2018: Public Health
Maree Johnson, Tracy Levett-Jones, R Langdon, Gabrielle Weidemann, Elizabeth Manias, Bronwyn Everett
OBJECTIVES: We sought to evaluate the perceptions of nurses of an e-learning educational program to encourage the use of behavioural strategies-blocking, engaging, mediating, multitasking, and preventing-to reduce the negative effects of interruptions during medication administration. DESIGN: A qualitative design was used to evaluate the impact of this e-learning educational intervention on nurses' behaviour. SETTINGS: Two wards (palliative care and aged care) from two different hospitals within a large local health service within Sydney Australia, were included in the study...
June 30, 2018: Nurse Education Today
Olumuyiwa Omonaiye, Pat Nicholson, Snezana Kusljic, Elizabeth Manias
OBJECTIVE: We evaluated the effectiveness of interventions aimed at improving antiretroviral therapy (ART) adherence during pregnancy in sub-Saharan Africa. METHODS: For this meta-analysis, the following databases were searched: MEDLINE Complete, Embase, Global Health, CINAHL Complete, and Google Scholar. Randomized and nonrandomized studies were considered for inclusion if they involved an intervention with the intent of improving medication adherence among pregnant women taking ART in sub-Saharan Africa...
July 9, 2018: International Journal of Infectious Diseases: IJID
Kathryn Fletcher, Fiona Foley, Neil Thomas, Erin Michalak, Lesley Berk, Michael Berk, Steve Bowe, Sue Cotton, Lidia Engel, Sheri L Johnson, Steven Jones, Michael Kyrios, Sara Lapsley, Cathrine Mihalopoulos, Tania Perich, Greg Murray
BACKGROUND: The primary objective of this randomised controlled trial (RCT) is to establish the effectiveness of a novel online quality of life (QoL) intervention tailored for people with late stage (≥ 10 episodes) bipolar disorder (BD) compared with psychoeducation. Relative to early stage individuals, this late stage group may not benefit as much from existing psychosocial treatments. The intervention is a guided self-help, mindfulness based intervention (MBI) developed in consultation with consumers, designed specifically for web-based delivery, with email coaching support...
July 13, 2018: BMC Psychiatry
Douglass Godwin, Kathryn I Alpert, Lei Wang, Daniel Mamah
BACKGROUND: Schizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The current study investigates cortical thickness in young adults diagnosed with schizophrenia or bipolar I disorder with a history of hyperthymic mania. We hypothesize that cortical thickness will be most similar between SCZ and the psychotic bipolar 1 disorder subtype. METHODS: Patients with schizophrenia (n = 52), psychotic bipolar I disorder (PBD; n = 49) and non-psychotic bipolar I disorder (NPBD; n = 24) and healthy controls (n = 40) were scanned in a 3T Trio MRI...
July 11, 2018: International Journal of Bipolar Disorders
Dawn A Manias, Gary M Dunny
It was shown previously that disruption of the ahrC gene encoding a predicted ArgR family transcription factor results in a severe defect in biofilm formation in vitro, as well as significant attenuation of virulence of E. faecalis OG1RF in multiple experimental infection models. Using RNA-seq, we observed ahrC -dependent changes in expression of over 20 genes. AhrC-repressed genes included predicted determinants of arginine catabolism and several other metabolic genes and predicted transporters, while AhrC-activated genes included determinants involved in production of surface protein adhesins...
July 9, 2018: Journal of Bacteriology
Ethan Anglemyer, Craig Crespi
The Deaf/hard of hearing population is growing rapidly and the medical community is facing a higher demand for this special needs group. The Deaf culture is unique in that spoken word is via sign language. What one person may see as mania or psychosis is actually a norm with Deaf individuals. The fear of the unknown language often creates immediate conclusions that are false. As such, being culturally sensitive becomes a large component of properly assessing a Deaf patient in any psychiatric situation. In the first case, the patient is a 26-year-old prelingually Deaf male, who was placed under an involuntary hold by the emergency room physician for acting erratic and appearing to respond to internal stimuli...
2018: Case Reports in Psychiatry
V Lequimener-de Lorgeril, M Chirio-Espitalier, M Grall-Bronnec
INTRODUCTION: Bipolar disorder is a mental illness that is associated with a long-term impairment in psychosocial functioning and quality of life. The objective of this study was to evaluate the influence of a therapeutic education program on the quality of life of patients with bipolar disorder (type 1 or 2). METHOD: This study included 18 patients with bipolar disorder (type 1 or 2) following the therapeutic education program on bipolar disorder which includes 8 sessions of 2hours each...
July 5, 2018: L'Encéphale
Etieli Wendler, Camila Pasquini de Souza, Ana Paula Segantine Dornellas, Luis Eduardo Dos Santos, Sergio Texeira Ferreira, José Carlos Fernandes Galduróz, Markus Wöhr, Rainer K W Schwarting, Roberto Andreatini
Mania is characterized by elevated drive and mood but animal models of mania have often neglected elevated mood. Ultrasonic vocalizations (USV) of 50-kHz emitted by rats are thought to index the subject's positive affective state. Fifty-kHz USV emission is increased by amphetamine, an effect blocked by lithium administration. Sleep deprivation (SD) is an environmental model of mania and the present study evaluated SD effects on behavioral activity and USV emission, together with the impact of lithium treatment...
July 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Roger S McIntyre, Allan H Young, Peter M Haddad
The simultaneous occurrence of manic and depressive features has been recognized since classical times, but the term 'mixed state' was first used by Kraepelin at the end of the 19th century. From the 1980s, until the advent of the Diagnostic and Statistical Manual of Mental Disorders , fifth edition (DSM-5), psychiatric disorders were classified using a categorical approach. However, it was recognized that such an approach was too rigid to encompass the range of symptomatology encountered in clinical practice...
June 2018: Therapeutic Advances in Psychopharmacology
Angelo Bruschi, Marianna Mazza, Giovanni Camardese, Salvatore Calò, Claudia Palumbo, Laura Mandelli, Antonino Callea, Alessio Gori, Marco Di Nicola, Giuseppe Marano, Michael Berk, Guido di Sciascio, Luigi Janiri
Background: Aim of the study was the validation of the Bipolar Disorder Rating Scale (BDRS) in an Italian population. Secondary aim was the evaluation of differences between unipolar and bipolar depression and between bipolar I and II depressed patients. Method: 125 Bipolar Disorder and 60 Major Depressive Disorder patients were administered an Italian translation of the BDRS (I-BDRS), Hamilton Depression Rating Scale (HDRS), Montgomery-Asberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Temperament and Character Inventory-Revised (TCI-R)...
2018: Frontiers in Psychology
Katrina A S Davis, Jonathan R I Coleman, Mark Adams, Naomi Allen, Gerome Breen, Breda Cullen, Chris Dickens, Elaine Fox, Nick Graham, Jo Holliday, Louise M Howard, Ann John, William Lee, Rose McCabe, Andrew McIntosh, Robert Pearsall, Daniel J Smith, Cathie Sudlow, Joey Ward, Stan Zammit, Matthew Hotopf
Background: UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims: An online mental health questionnaire completed by UK Biobank participants was expected to expand the potential for research into mental disorders. Method: An expert working group designed the questionnaire, using established measures where possible, and consulting with a patient group regarding acceptability...
May 2018: BJPsych Open
Mohammadreza Moradi, Massoud Saidijam, Reza Yadegarazari, Leila Jahangard, Maryam Seifi, Nasrin Matinnia, Ali Ghaleiha
Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder. Methods: In this study, 22 patients with bipolar I disorder (single manic episode) and 22 healthy individuals were enrolled...
March 2018: Basic and Clinical Neuroscience
Jac Kee Low, Kimberley Crawford, Elizabeth Manias, Allison Williams
Background Kidney transplantation is an effective treatment, but it is not a cure. Since the risk of graft rejection and the presence of comorbid conditions remain for a lifetime, medications are necessary. Objective To examine the prescription medication burden of adult kidney transplant recipients from 3- to 12-months post-transplantation. Setting All five adult kidney transplant units in Victoria, Australia. Method As part of a larger intervention study, we conducet a retrospective review of prescription refill records and medical records containing the history of medication changes of 64 participants who completed the study was undertaken...
June 28, 2018: International Journal of Clinical Pharmacy
Jack J Chen
Persistent psychotic symptoms will develop in up to 60% of patients with Parkinson disease (PD). The initial approach to the management of PD psychosis (PDP) begins with addressing concurrent systemic conditions associated with psychotic behavior, such as delirium, medical conditions (eg, infections), psychiatric disorders (eg, major depression with psychotic symptoms, mania, schizophrenia), and substance misuse or withdrawal. A review of current medications is recommended, and medications that may trigger psychotic symptoms should be eliminated...
November 2017: The mental health clinician
Vincent Khung Hoon Wong, Phern Chern Tor, Donel M Martin, Yee Ming Mok, Colleen Loo
OBJECTIVE: Electroconvulsive therapy (ECT) is an effective treatment in mania. However, there is little evidence regarding the use of ultrabrief right unilateral (RUL-UB) ECT in treatment of acute manic episodes. The aim of this study was to report on the effectiveness and cognitive profile of ECT in bipolar mania, including a sample who received RUL-UB ECT. METHODS: This naturalistic study retrospectively collected data in 33 patients who received ECT with concurrent antipsychotics for mania between October 1, 2014, and July 30, 2016...
June 26, 2018: Journal of ECT
Mallik Greene, Luciano Paladini, Teresa Lemmer, Alexandra Piedade, Maelys Touya, Otavio Clark
Background: Bipolar disorder type I (BD-I) is a chronic condition characterized by mania episodes followed by syndromic recovery periods, usually permeated by depressive symptoma-tology and recurring acute manic episodes. It requires long-term pharmacological treatment; thus, it is critical to understand the patterns of drug therapy use and medication compliance to better plan health care policies and needs. This systematic literature review aims to study these data among patients with BD-I in the USA, focusing on medications to treat mania...
2018: Neuropsychiatric Disease and Treatment
Hesitha Abeysundera, Ramandeep Gill
This paper describes a patient who presented with mania with psychotic features in the context of concomitant use of S-adenosyl-L-methionine (SAMe) and selective serotonin reuptake inhibitor (SSRI). The aim of this case report is to provide medical practitioners with a greater awareness of the possibility of a psychotic episode and/or mania manifesting with concurrent use of SAMe and SSRI.
June 27, 2018: BMJ Case Reports
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