keyword
https://read.qxmd.com/read/38312190/cg02n-analyzer-accurately-measures-fibrinogen-level-in-whole-blood-in-the-presence-of-low-or-high-dose-heparin
#1
JOURNAL ARTICLE
Yoshihiko Nakamura, Junichi Maruyama, Takehiro Umemura, Kota Hoshino, Yuhei Irie, Shinichi Morimoto, Yoshito Izutani, Hiroyasu Ishikura
Rapid fibrinogen (Fbg) evaluation is important in patients with massive bleeding during severe trauma and those undergoing major surgery. However, there are only a few studies on the point-of-care Fbg analyzer. In this study, we aimed to investigate the accuracy of Fbg level measured using CG02N, with whole blood contained in lithium-heparinized syringes with two different concentrations of heparin. Blood samples were collected in lithium-heparinized tubes, namely PREZA-PAK®II (low-dose heparin group [LG], 7 IU/mL) and Pro-Vent® Plus (high-dose heparin group [HG], 70...
January 2024: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/38256458/the-utility-of-intravenous-methylprednisolone-as-an-adjunct-treatment-for-drug-resistant-amiodarone-induced-thyrotoxicosis
#2
Krzysztof Cezary Lewandowski, Joanna Kawalec, Michał Kusiński, Katarzyna Dąbrowska, Aleksandra Ewa Matusiak, Iga Dudek, Andrzej Lewiński
BACKGROUND: Amiodarone-induced thyrotoxicosis (AIT) may pose treatment challenges. We present a series of patients in which we achieved the normalisation of free T3 (FT3) using intravenous methylprednisolone (ivMP) in AIT refractory to thiamazole and oral prednisone. Namely, in three males (aged 56, 50 and 64, all with a history of AF and/or a low ejection fraction), an addition of ivMP resulted in the normalisation of FT3, which allowed successful thyroidectomy. In another case of a 65-year-old man, we initially succeeded in the normalisation of FT3 using ivMP from FT4 > 7...
January 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38253184/comparative-efficacy-tolerability-and-acceptability-of-donanemab-lecanemab-aducanumab-and-lithium-on-cognitive-function-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-systematic-review-and-network-meta-analysis
#3
REVIEW
Itsuki Terao, Wakako Kodama
BACKGROUND: The comparative clinical utility of the disease-modifying treatments for mild cognitive impairment and Alzheimer's disease that are approved or under review by the Food and Drug Administration (i.e., donanemab, lecanemab and aducanumab), and lithium, which is a potential disease-modifying agent for this condition, remains elusive. OBJECTIVE: We aimed to compare the efficacy on cognitive decline, tolerability and acceptability of these drugs in this condition...
February 2024: Ageing Research Reviews
https://read.qxmd.com/read/38252254/inhibition-of-mitochondrial-calcium-transporters-alters-adp-induced-platelet-responses
#4
JOURNAL ARTICLE
Durre Shehwar, Saima Barki, Alessandro Aliotta, Lucas Veuthey, Debora Bertaggia Calderara, Lorenzo Alberio, Muhammad Rizwan Alam
INTRODUCTION: ADP-stimulated elevation of cytosolic Ca2+ is an important effector mechanism for platelet activation. The rapidly elevating cytosolic Ca2+ is also transported to mitochondrial matrix via Mitochondrial Ca2+ Uniporter (MCU) and extruded via Na+ /Ca2+ /Li+ Exchanger (NCLX). However, the exact contribution of MCU and NCLX in ADP-mediated platelet responses remains incompletely understood. METHODS AND RESULTS: The present study aimed to elucidate the role of mitochondrial Ca2+ transport in ADP-stimulated platelet responses by inhibition of MCU and NCLX with mitoxantrone (MTX) and CGP37157 (CGP), respectively...
January 22, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38172585/using-the-photon-isoeffective-dose-formalism-to-compare-and-combine-bnct-and-cirt-in-a-head-and-neck-tumour
#5
JOURNAL ARTICLE
Ian Postuma, Chiara Magni, Barbara Marcaccio, Setareh Fatemi, Valerio Vercesi, Mario Ciocca, Giuseppe Magro, Ester Orlandi, Barbara Vischioni, Sara Ronchi, Yuan-Hao Liu, Yang Han, Changran Geng, Sara Josefina González, Silva Bortolussi
Boron Neutron Capture Therapy (BNCT) is a radiotherapy technique based on the enrichment of tumour cells with suitable 10-boron concentration and on subsequent neutron irradiation. Low-energy neutron irradiation produces a localized deposition of radiation dose caused by boron neutron capture reactions. Boron is vehiculated into tumour cells via proper borated formulations, able to accumulate in the malignancy more than in normal tissues. The neutron capture releases two high-LET charged particles (i.e., an alpha particle and a lithium ion), losing their energy in a distance comparable to the average dimension of one cell...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38164924/estimating-lithium-concentrations-in-groundwater-used-as-drinking-water-for-the-conterminous-united-states
#6
JOURNAL ARTICLE
Melissa A Lombard, Eric E Brown, Daniel M Saftner, Monica M Arienzo, Esme Fuller-Thomson, Craig J Brown, Joseph D Ayotte
Lithium (Li) concentrations in drinking-water supplies are not regulated in the United States; however, Li is included in the 2022 U.S. Environmental Protection Agency list of unregulated contaminants for monitoring by public water systems. Li is used pharmaceutically to treat bipolar disorder, and studies have linked its occurrence in drinking water to human-health outcomes. An extreme gradient boosting model was developed to estimate geogenic Li in drinking-water supply wells throughout the conterminous United States...
January 2, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38032417/high-lithium-concentration-at-delivery-is-a-potential-risk-factor-for-adverse-outcomes-in-breastfed-infants-a-retrospective-cohort-study
#7
JOURNAL ARTICLE
Essi Whaites Heinonen, Katarina Tötterman, Karin Bäck, Ihsan Sarman, Lisa Forsberg, Jenny Svedenkrans
BACKGROUND: Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother's own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by placental lithium transfer or postnatal exposure to lithium through breastfeeding. We aimed to investigate lithium clearance and neonatal morbidity in breastfed infants with high versus low serum lithium concentrations at birth. METHODS: This retrospective study focused on breastfed infants to women treated with lithium during and after pregnancy, born between 2006 and 2021 in Stockholm, Sweden...
November 30, 2023: International Journal of Bipolar Disorders
https://read.qxmd.com/read/37983988/breakthrough-curve-analysis-of-phosphorylated-hazelnut-shell-waste-in-column-operation-for-continuous-harvesting-of-lithium-from-water
#8
JOURNAL ARTICLE
Yaşar Kemal Recepoğlu, Özgür Arar, Aslı Yüksel
In batch-scale operations, biosorption employing phosphorylated hazelnut shell waste (FHS) revealed excellent lithium removal and recovery efficiency. Scaling up and implementing packed bed column systems necessitates further design and performance optimization. Lithium biosorption via FHS was investigated utilizing a continuous-flow packed-bed column operated under various flow rates and bed heights to remove Li to ultra-low levels and recover it. The Li biosorption capacity of the FHS column was unaffected by the bed height, however, when the flow rate was increased, the capacity of the FHS column decreased...
November 14, 2023: Journal of Chromatography. A
https://read.qxmd.com/read/37979298/aqueous-heterocoagulation-driven-assembly-of-graphene-oxide-and-polycation-coated-sulfur-particles-for-nanocomposite-li-s-battery-cathodes
#9
JOURNAL ARTICLE
Péter B Nagy, Lakshmi Shiva Shankar, Márton Szabados, Hala Roumia, Ákos Kukovecz, Robert Kun, Tamás Szabó
HYPOTHESIS: Reduced graphene oxide (rGO/polycation/sulfur) composites are promising cathode materials for Li-S battery applications because homogeneously dispersed sulfur nano/micro clusters in suitable carbon hosts enable remarkable cycle life for Li-S battery cells. New, benign and economic synthesis methods based only on aqueous colloidal dispersions are demanded for achieving high dispersity grade of sulfur within the carbon host. Colloidal interactions leading to heteroaggregation between carbonaceous lamellae and polycation-modified sulphur nanoparticles at ambient conditions in water are foreseen to afford nanocomposite cathodes, which maintain excellent electrochemical performance...
November 8, 2023: Journal of Colloid and Interface Science
https://read.qxmd.com/read/37913863/differential-regulation-of-wnt-%C3%AE-catenin-signaling-in-acute-and-chronic-epilepsy-in-repeated-low-dose-lithium-pilocarpine-rat-model-of-status-epilepticus
#10
JOURNAL ARTICLE
Kajal Rawat, Vipasha Gautam, Arushi Sandhu, Alka Bhatia, Lekha Saha
Epilepsy is a chronic neurological complication characterized by unprovoked seizure episodes due to the imbalance between excitatory and inhibitory neurons. The epileptogenesis process has been reported to be involved in chronic epilepsy however, the mechanism underlying epileptogenesis remains unclear. Recent studies have shown the possible involvement of Wnt/β-catenin signaling in the neurogenesis and neuronal reorganization in epileptogenesis. In this study, we used repeated low dose lithium-pilocarpine model of status epilepsy (SE) to study the involvement of Wnt/β-catenin signaling at acute and chronic stages post SE induction...
December 15, 2023: Neuroscience
https://read.qxmd.com/read/37887045/prevalence-of-cobalt-in-the-environment-and-its-role-in-biological-processes
#11
REVIEW
Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano, Alessia Carocci, Maria Stefania Sinicropi
Cobalt (Co) is an essential trace element for humans and other animals, but high doses can be harmful to human health. It is present in some foods such as green vegetables, various spices, meat, milk products, seafood, and eggs, and in drinking water. Co is necessary for the metabolism of human beings and animals due to its key role in the formation of vitamin B12 , also known as cobalamin, the biological reservoir of Co. In high concentrations, Co may cause some health issues such as vomiting, nausea, diarrhea, bleeding, low blood pressure, heart diseases, thyroid damage, hair loss, bone defects, and the inhibition of some enzyme activities...
October 16, 2023: Biology
https://read.qxmd.com/read/37882688/pharmacogenetic-testing-may-benefit-people-receiving-low-dose-lithium-in-clinical-practice
#12
JOURNAL ARTICLE
Michael Ray Dickerson, Jennifer Reed
BACKGROUND: Mental illnesses are leading causes of disability in the United States. Some evidence supports that pharmacogenetic testing may be beneficial in select populations and that lithium is beneficial for treating mood disorders and anxiety in some populations. PURPOSE: This research aimed to determine whether low-dose lithium effectively decreases depression and anxiety in adults with a risk allele for CACNA1C genotypes. METHODOLOGY: The study design was correlational...
October 26, 2023: Journal of the American Association of Nurse Practitioners
https://read.qxmd.com/read/37838729/low-dose-lithium-adjunct-to-atypical-antipsychotic-treatment-nearly-improved-cognitive-impairment-deteriorated-the-gray-matter-volume-and-decreased-the-interleukin-6-level-in-drug-naive-patients-with-first-schizophrenia-symptoms-a-follow-up-pilot-study
#13
JOURNAL ARTICLE
Chuanjun Zhuo, Shuiqing Hu, Guangdong Chen, Lei Yang, Ziyao Cai, Hongjun Tian, Deguo Jiang, Chunmian Chen, Lina Wang, Xiaoyan Ma, Ranli Li
This study was conducted to investigate the effects of long-term low-dose lithium adjunct to antipsychotic agent use on the cognitive performance, whole-brain gray-matter volume (GMV), and interleukin-6 (IL-6) level in drug-naive patients with first-episode schizophrenia, and to examine relationships among these factors. In this double-blind randomized controlled study, 50 drug-naive patients with first-episode schizophrenia each took low-dose (250 mg/day) lithium and placebo (of the same shape and taste) adjunct to antipsychotic agents (mean, 644...
October 14, 2023: Schizophrenia (Heidelb)
https://read.qxmd.com/read/37801996/evaluating-the-effect-of-low-density-inhomogeneities-a-comparative-study-of-lithium-fluoride-detectors-radiochromic-films-and-collapsed-cone-algorithm-in-6%C3%A2-mv-photon-beams
#14
JOURNAL ARTICLE
Anna Luiza Fraga da Silveira, Fernanda da Silva Gonçalves Araújo, Daniel Silva Calheiro, André Luiz Tavares E Silva, Bruno Rodrigues Gonçalves, André Lima de Souza Castro, Arnie Verde Nolasco, Luiz Claudio Meira-Belo
In recent years, there has been significant advancement in the development of physical simulators for dose evaluation. Many dosimetric studies employ solid materials, equivalent to human tissues, to evaluate dose distribution. This study aims to evaluate the effectiveness of inhomogeneity correction carried out by the Monaco/Elekta radiotherapy planning software. To achieve this goal, a physical simulator was created using cork boards to simulate lung tissue and solid water to represent other tissues. This simulator was combined with a dosimetric system that utilized lithium fluoride thermoluminescent detectors - RADOS MTS-N (LiF:Mg,Ti)...
September 22, 2023: Applied Radiation and Isotopes
https://read.qxmd.com/read/37782983/synthesis-characterization-and-thermoluminescence-properties-of-licapo-4-phosphor-for-ionizing-radiation-dosimetry
#15
JOURNAL ARTICLE
Md Raghib Rahat, Homaira Afia Mimi, Shah Azharul Islam, Md Kamruzzaman, Jannatul Ferdous, Mahfuza Begum, Md Abul Hasnat, H A Abdul-Rashid, Umme Muslima, Mayeen Uddin Khandaker, D A Bradley, Md Al-Mamun, A K M Mizanur Rahman
Many minerals and compounds show thermoluminescence (TL) properties but only a few of them can meet the requirements of an ideal dosimeter. Several phosphate materials have been studied for low-dose dosimetryin recent times. Among the various phosphates, ABPO4 -type material shows interesting TL properties. In this study, an ABPO4 -type (A = Lithium, B=Calcium) phosphor is synthesized using a modified solid-state diffusion method. Temperature is maintained below 800 °C in every step of phosphor preparation to obtain the pure phase of Lithium calcium phosphate (LiCaPO4 )...
September 27, 2023: Applied Radiation and Isotopes
https://read.qxmd.com/read/37732619/effects-of-lithium-on-serum-brain-derived-neurotrophic-factor-in-alzheimer-s-patients-with-agitation
#16
RANDOMIZED CONTROLLED TRIAL
Deborah A Deliyannides, Jamie A Graff, Izael Niño, Seonjoo Lee, Mustafa M Husain, Brent P Forester, Elizabeth Crocco, Ipsit V Vahia, Davangere P Devanand
BACKGROUND: There is ample evidence in animal models that lithium increases Brain-Derived Neurotrophic Factor (BDNF) with supporting evidence in human studies. Little is known, however, about the effects of lithium on BDNF in Alzheimer's Dementia (AD). In one study of patients with Mild Cognitive Impairment, serum BDNF increased after treatment with lithium. These patients also showed mild improvement in cognitive function. OBJECTIVES: To evaluate low-dose lithium treatment of agitation in Alzheimer's disease (AD)...
September 2023: International Journal of Geriatric Psychiatry
https://read.qxmd.com/read/37721086/improvement-of-neutron-sensitivity-for-lithium-formate-epr-dosemeters-a-monte-carlo-analysis
#17
JOURNAL ARTICLE
Maria Cristina D'Oca, Giorgio Collura, Cesare Gagliardo, Antonio Bartolotta, Mattia Romeo, Francesco d'Errico, Maurizio Marrale
This work presents the computational analysis of the sensitivity improvements that could be achieved in lithium formate monohydrate (LFM) electron paramagnetic resonance (EPR) dosemeters exposed to neutron beams. Monte Carlo (MC) simulations were performed on LFM pellets exposed to neutron beams with different energy spectra at various depths inside a water phantom. Various computations were carried out by considering different enrichments of 6Li inside the LFM matrix as well as addition of different amounts of gadolinium oxide inside the pellet blend...
September 18, 2023: Radiation Protection Dosimetry
https://read.qxmd.com/read/37704933/low-and-very-low-lithium-levels-thyroid-effects-are-small-but-still-require-monitoring
#18
JOURNAL ARTICLE
James Phelps, Olivia Pipitone Coskey
AIM: Low doses of lithium, as might be used for mood or dementia prevention, do not carry the same renal, toxicity, and tolerability problems of doses used for prophylaxis or treatment of mania. However, thyroid effects of low doses have not been investigated. Our goal in this study was to assess the changes in thyroid-stimulating hormone (TSH) associated with a broad range of lithium levels, including those well below the therapeutic range for bipolar disorders. METHODS: This study was conducted in a small healthcare system with 19 associated primary care clinics served by a Collaborative Care program of psychiatric consultation...
September 13, 2023: Bipolar Disorders
https://read.qxmd.com/read/37686565/tp53-and-the-ultimate-biological-optimization-steps-of-curative-radiation-oncology
#19
REVIEW
Anders Brahme
The new biological interaction cross-section-based repairable-homologically repairable (RHR) damage formulation for radiation-induced cellular inactivation, repair, misrepair, and apoptosis was applied to optimize radiation therapy. This new formulation implies renewed thinking about biologically optimized radiation therapy, suggesting that most TP53 intact normal tissues are low-dose hypersensitive (LDHS) and low-dose apoptotic (LDA). This generates a fractionation window in LDHS normal tissues, indicating that the maximum dose to organs at risk should be ≤2...
August 27, 2023: Cancers
https://read.qxmd.com/read/37587893/the-neuroprotective-effect-of-dl-3-n-butylphthalide-in-epileptic-rats-via-inhibiting-endoplasmic-reticulum-stress
#20
JOURNAL ARTICLE
Shuang Tian, Zhenzhen Qu, Huifang Cao, Xiaoli Niu, Qi Qiao, Bing Zhang, Lijing Jia, Weiping Wang
INTRODUCTION: The purpose of this study is to investigate whether Dl-3-n-Butylphthalide (NBP) has a neuroprotective effect on pilocarpine-induced epileptic (EP) rats through endoplasmic reticulum stress (ERS)-mediated apoptosis. MATERIAL AND METHODS: The Sprague-Dawley rats were divided into four groups: control (CON), EP, EP + NBP 60 (NBP 60 mg/kg) and EP + NBP 120 (NBP 120 mg/kg) groups. After the successful establishment of the temporal lobe EP model using the lithium-pilocarpine, the rats were given NBP for 28 consecutive days in EP + NBP 60 and EP + NBP 120 groups...
2023: Folia Neuropathologica
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