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https://www.readbyqxmd.com/read/28747629/clownfish-in-hypoxic-anemones-replenish-host-o2-at-only-localised-scales
#1
N A Herbert, S Bröhl, K Springer, A Kunzmann
The clownfish-anemone association exemplifies a symbiosis where both members benefit from nutrient exchange and protection from predators. Clownfish also perform aeration-like behaviour in their host anemones at night, but it is not yet known whether this is stimulated by the onset of hypoxia, and whether both members benefit from O2 replenishment. Oxygen at 3 distances above the sea anemone Entacmaea quadricolor (0.2, 1.2 and 2.2 cm) therefore was measured under 3 light levels (photon flux density = 0, 55 and 110 µmol m(-2) s(-1)), with and without the anemonefish Amphiprion frenatus...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747133/retroperitoneal-laparoscopic-nephrotomy-along-the-brodel-line-and-tumor-enucleation-te-for-complete-intra-parenchymal-renal-tumors-a-single-institution-experience
#2
Baojun Wang, Huijie Gong, Xin Ma, Hong Zhao Li, Yongji Yan, Wei Cai, Lixin Shi, Xintao Li, Xu Zhang
PURPOSE: To evaluate the feasibility and outcomes of retroperitoneal laparoscopic nephrotomy along the Brodel line and tumor enucleation (TE) for complete intra-parenchymal renal tumors. PATIENTS AND METHODS: We retrospectively analysed the medical charts of patients with complete endophytic tumors and who underwent retroperitoneal laparoscopic nephrotomy along the Brodel line and TE between 2012 and 2015. Peri-operative data, surgical technique, pathological variables, complications, functional and oncological outcomes were reviewed...
July 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28746413/insomnia-with-objective-short-sleep-duration-is-associated-with-longer-duration-of-insomnia-in-the-freiburg-insomnia-cohort-compared-to-insomnia-with-normal-sleep-duration-but-not-with-hypertension
#3
Anna F Johann, Elisabeth Hertenstein, Simon D Kyle, Chiara Baglioni, Bernd Feige, Christoph Nissen, Alastair J McGinness, Dieter Riemann, Kai Spiegelhalder
STUDY OBJECTIVES: To replicate the association between insomnia with objective short sleep duration and hypertension, type 2 diabetes and duration of insomnia. DESIGN: Retrospective case-control study. SETTING: Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg. PARTICIPANTS: 328 patients with primary insomnia classified according to DSM-IV criteria (125 males, 203 females, 44.3 ± 12.2 years)...
2017: PloS One
https://www.readbyqxmd.com/read/28745684/-autoinflammatory-diseases-and-kidney-involvement
#4
EDITORIAL
N A Mukhin, M V Bogdanova, V V Rameev, L V Kozlovskaya
Autoinflammatory disease (AID) is a new concept formulated from the results of studying the pathogenesis of familial periodic fevers, a heterogeneous group of genetically determined diseases characterized by causelessly recurrent exacerbations of the inflammatory process due to genetically determined disorders of innate immunity and accompanied by uncontrolled hypersecretion of interleukin-1 (IL-1). These mechanisms were a basic model for understanding a wide range of rheumatologic and other inflammatory diseases of the internal organs...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745672/-gender-aspects-of-medico-social-adaptation-in-adults-with-early-onset-of-epilepsy
#5
O V Grebenyuk, T V Kazennykh, V M Alifirova, M V Svetlik, N A Bokhan
AIM: To study the relationship between indicators of clinical picture and social adaptation in idiopathic and symptomatic epilepsies with onset before adulthood depending on patient's gender. MATERIAL AND METHODS: The cross-sectional study was carried out. The study group included 212 women and 171 men, aged 24-60 years, with confirmed diagnosis of epilepsy with onset before 18 years. Seventy-three patients were diagnosed with symptomatic epilepsy, 310 with idiopathic epilepsy...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28745661/-n-s-i-n-i-v-biomechanical-aspects-of-anterior-capsulotomy-in-cataract-surgery
#6
K S Avetisov, N A Bakhchieva, S E Avetisov, I A Novikov, N V Belikov, I V Khaydukova
This paper reviews studies on biomechanical properties of the anterior lens capsule. Early experiments in this field were more fundamental. Later studies were aimed mainly at assessing the mechanical stability of the capsule edge after manual or femtosecond laser capsulorhexis (capsulotomy) - an important step in modern minimally invasive phaco surgery. For biomechanical tests, ex vivo samples of human and animal anterior capsules were used. The results of the studies presented here are quite heterogeneous, which suggests the necessity of gaining further insight into the issue...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28745650/-comparative-analysis-of-corneal-aberrations-after-intrastromal-segments-and-myoring-implantation-using-femtosecond-laser-in-patients-with-keratoconus
#7
N P Pashtaev, N A Pozdeeva, M V Sinitsyn
AIM: to comparatively analyze corneal aberrations after intrastromal corneal segments (ICS) and MyoRing implantation using femtosecond laser in patients with stage II-III keratoconus (KC) by Pentacam examination. MATERIAL AND METHODS: We have operated on 135 patients (145 eyes) with stage II or III KC. Depending on surgical technique, all patients were divided into two groups. Group I consisted of patients with KC, who received optimized femtosecond laser-assisted MyoRing implantation, group II - of those, who received femtosecond laser-assisted ICS implantation...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28745248/-diagnosis-and-treatment-of-orbital-cellulitis
#8
N A van der Poel, E G van der Veer, F A Ebbens, M M de Win, R J Kloos, M P Mourits
Orbital cellulitis is a rare disease usually caused by sinusitis. Generally, the prognosis of both preseptal cellulitis and orbital cellulitis is favourable. Radiological distinction should be made between an orbital abscess and subperiosteal empyema. Theoretically, empyema is more accessible to antibiotics and, as it arises in a pre-existing anatomical space, it needs less aggressive treatment than an abscess. In contrast, the wall of an abscess created by the bacteria is scarcely permeable to antibiotics...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28744653/lipoxygenase-inhibitors-nordihydroguaiaretic-acid-and-fungus-lecanicillum-lecanii-extract-induce-death-of-lymphoid-leukemia-cells
#9
M V Bibikova, N A Spiridonova, A F Korystova, L N Kublik, M Kh Levitman, V V Shaposhnikova, Yu N Korystov
We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells...
July 26, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28744651/high-antimetastatic-activity-of-platin-liposomal-form-after-lyophilization-and-storage
#10
V I Kaledin, V P Nikolin, N A Popova, M G Klinnikova, L A Bogdanova, T S Morozkova
Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31...
July 26, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28744641/effect-of-chronic-administration-of-obestatin-and-its-fragment-fnap-nh2-on-behavioral-activity-and-nociceptive-threshold-in-rats-with-normal-and-excess-body-weight
#11
E E Khirazova, E S Motorykina, M V Maslova, A S Maklakova, A V Graf, N A Sokolova, A A Kamenskii
The effects of chronic intranasal administration of 300 nmol/kg obestatin and its fragment FNAP-NH2 on behavioral activity and nociceptive threshold were examined in male Wistar rats with normal body weight or alimentary obesity. In normal rats, obestatin produced no effect on behavior and nociception, whereas FNAP-NH2 fragment enhanced risk-taking behavior. Rats with excess body weight demonstrated less pronounced risk-taking behavior and elevated nociceptive threshold in comparison with normal animals, but these differences were abolished by chronic administration of FNAP-NH2...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28744640/features-of-lipoperoxidation-antioxidant-defense-and-thiol-disulfide-system-in-the-pathogenesis-of-infertility-in-males-carriers-of-nonfunctional-variants-of-gstt1-and-gstm1-gene-polymorphisms
#12
L I Kolesnikova, N A Kurashova, T A Bairova, M I Dolgikh, O A Ershova, L V Natyaganova, B G Dashiev, I N Gutnik, N V Koroleva
Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28741449/meetings-calendar
#13
Aubrey D N J de Grey
n/a.
July 25, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28739117/update-on-fertility-preservation-from-the-barcelona-international-society-for-fertility-preservation-eshre-asrm-2015-expert-meeting-indications-results-and-future-perspectives
#14
Francisca Martinez
STUDY QUESTION: What progress has been made in fertility preservation (FP) over the last decade? SUMMARY ANSWER: FP techniques have been widely adopted over the last decade and therefore the establishment of international registries on their short- and long-term outcomes is strongly recommended. WHAT IS KNOWN ALREADY: FP is a fundamental issue for both males and females whose future fertility may be compromised. Reproductive capacity may be seriously affected by age, different medical conditions and also by treatments, especially those with gonadal toxicity...
July 20, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28736444/lipid-droplet-remodelling-and-reduced-muscle-ceramides-following-sprint-interval-and-moderate-intensity-continuous-exercise-training-in-obese-males
#15
S O Shepherd, M Cocks, P J Meikle, N A Mellett, A M Ranasinghe, T A Barker, A J M Wagenmakers, C S Shaw
BACKGROUND: In obesity, improved muscle insulin sensitivity following exercise training has been linked to the lowering of diacylglycerol (DAG) and ceramide concentrations. Little is known, however, about how improved insulin action with exercise training in obese individuals relates to lipid droplet (LD) adaptations in skeletal muscle. In this study we investigated the hypothesis that short-term sprint interval training (SIT) and moderate intensity continuous training (MICT) in obese individuals would increase perilipin (PLIN) expression, increase the proportion of LDs in contact with mitochondria and reduce muscle concentrations of DAGs and ceramides...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28735295/azithromycin-for-episodes-with-asthma-like-symptoms-in-young-children-aged-1-3-years
#16
Katy McConnell, Michael Shields
N/A.
July 22, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28735207/nutrient-balancing-for-phytoremediation-enhancement-of-urea-manufacturing-raw-wastewater
#17
Sara Yavari, Amirhossein Malakahmad, Nasiman B Sapari, Saba Yavari, Eakalak Khan
Application of urea manufacturing wastewater to teak (Tectona grandis) trees, a fast growing tropical timber plants, is an environmentally-friendly and cost-effective alternative for treatment of nitrogen-rich wastewater. However, the plant growth is strongly limited by lack of phosphorus (P) and potassium (K) elements when the plants are irrigated with wastewater containing high concentration of nitrogen (N). A greenhouse experiment was conducted to optimize the efficiency of teak-based remediation systems in terms of nutrient balance...
July 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28734103/levels-of-wound-calprotectin-and-other-inflammatory-biomarkers-aid-in-deciding-which-patients-with-a-diabetic-foot-ulcer-need-antibiotic-therapy-induce-study
#18
J R Ingram, S Cawley, E Coulman, C Gregory, E Thomas-Jones, T Pickles, R Cannings-John, N A Francis, K Harding, K Hood, V Piguet
AIMS: Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Four inflammatory biomarkers were investigated to develop a composite algorithm for mildly infected diabetic foot ulcers: venous white cell count, C-reactive protein (CRP) and procalcitonin, and a novel wound exudate calprotectin assay. Calprotectin is a marker of neutrophilic inflammation. METHODS: In a prospective study, people with uninfected or mildly infected diabetic foot ulcers who had not received oral antibiotics in the preceding 2 weeks were recruited from community podiatry clinics for measurement of inflammatory biomarkers...
July 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28733206/omics-based-identification-of-the-combined-effects-of-idiosyncratic-drugs-and-inflammatory-cytokines-on-the-development-of-drug-induced-liver-injury
#19
J Jiang, K Mathijs, L Timmermans, S M Claessen, A Hecka, J Weusten, R Peters, J H van Delft, J C S Kleinjans, D G J Jennen, T M de Kok
The mechanisms of idiosyncratic drug-induced hepatotoxicity remain largely unclear. It has demonstrated that the drug idiosyncrasy is potentiated in the context of inflammation and intracellular ceramides may play a role in this process. To study the mechanisms, HepG2 cells were co-treated with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, with (I+ and N+) or without (I- and N-) a cytokine mix. Microarray, lipidomics and flow cytometry were performed to investigate the genome-wide expression patterns, the intracellular ceramide levels and the induction of apoptosis...
July 18, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28731754/accidental-peccei-quinn-symmetry-protected-to-arbitrary-order
#20
Luca Di Luzio, Enrico Nardi, Lorenzo Ubaldi
A SU(N)_{L}×SU(N)_{R} gauge theory for a scalar multiplet Y transforming in the bifundamental representation (N,N[over ¯]) preserves, for N>4, an accidental U(1) symmetry first broken at operator dimension N. A vacuum expectation value for Y can break the symmetry to H_{s}=SU(N)_{L+R} or to H_{h}=SU(N-1)_{L}×SU(N-1)_{R}×U(1)_{L+R}. In the first case the accidental U(1) gets also broken, yielding a pseudo-Nambu-Goldstone boson with mass suppression controlled by N. In the second case a global U(1) remains unbroken...
July 7, 2017: Physical Review Letters
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