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https://www.readbyqxmd.com/read/29232758/-time-course-of-changes-in-visual-acuity-after-a-single-injection-of-aflibercept-or-ranibizumab-in-neovascular-age-related-macular-degeneration-analysis-of-aggregated-real-life-data
#1
Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
Background Treatment of neovascular age-related macular degeneration (nvAMD) under real life conditions may differ from controlled prospective trials with respect to the number of injections and long term preservation of visual acuity. In many instances, intervals for controls and re-injection cannot be maintained as frequently as required. This case series examines actual intervals for control and re-injection visits, in order to estimate how prolonged intervals have an impact on momentary visual acuity and how long term visual outcome is affected...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232757/-real-life-data-on-the-treatment-of-diabetic-macular-oedema-in-germany
#2
Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
Background Controlled prospective clinical trials on the treatment of diabetic macular oedema (DME) using anti-VEGF compounds show very good results in visual acuity gain over several years. To date, only limited data are available from comparable studies under real-life settings in clinical routine. However, real-life data from other indications for anti-VEGF treatment suggest that, in clinical routine, gain in visual acuity is less pronounced and cannot be maintained over a longer period of time, which is related to the significantly lower number of injections administered in clinical routine...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232756/-the-conundrum-of-relationships-in-the-multivariate-dataset-of-nvamd-treatment
#3
Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
Background The evaluation of relationships in clinical case series is complicated by statistical pitfalls, one of which is spurious correlation. In this case, one or more potential factors are actually not related to a target measure, yet it may be wrongly inferred that they are. This may be due to either coincidence or the presence of a one or more confounding unregarded factors. In randomised clinical trials, it is attempted to eliminate such confounding factors or to control them by randomisation. However, this approach is not applicable in retrospective case series, and other statistical methods must be applied, such as multivariate analyses, taking into account all known variables...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29232748/-combined-posteromedial-and-anterolateral-approach-in-the-floating-position-two-column-fracture-of-the-tibia-head
#4
Maike Reul, Harm Hoekstra
Background The posterior tibial plateau is often affected in intra-articular tibial fractures. Moreover, treating these posterior fractures is recognised as an important prognostic factor. Open reduction and internal fixation of lateral and posterior two column tibial plateau fractures can be achieved via a combined reversed L-shape approach and an anterolateral approach in the floating position without intraoperative repositioning of the patient. Material and Methods The operative procedure starts in the posterior position with visualisation of the posterior column after lateral retraction of the medial head of the M...
December 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29232726/-subtalare-screw-arthroereisis-for-the-treatment-of-symptomatic-flexible-pes-planovalgus
#5
Dariusch Arbab, Daniel Frank, Bertil Bouillon, Christian Lüring, Carsten Wingenfeld, Mona Abbara-Czardybon
Background The purpose of this study was to determine the functional outcomes and radiographic results of the talus-stop screw method as minimally invasive subtalar arthroereisis in pediatric and juvenile flexible flatfoot. Material and Methods We retrospectively evaluated 73 feet from 41 children using the talus stop-screw method, for the period between 2002 and 2011. The age at time of surgery ranged between nine and 14 years. The radiological assessment included measuring the calcaneal pitch, talar declination, talo-first metatarsal angle (Meary) and calcaneal-first metatarsal angle (Costa-Bartani) in the lateral view...
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29232725/value-of-contrast-enhanced-ultrasound-quantification-criteria-for-identifying-patients-not-responding-to-bevacizumab-based-therapy-for-colorectal-liver-metastases
#6
François Tranquart, Paul-Armand Dujardin, Olivier Bouché, Claude Marcus, Christophe Borg, Philippe Manzoni, Jean-Yves Douillard, Catherine Labbe-Devilliers, Eric Terrebonne, Denis Smith, Herve Trillaud, Olivier Capitain, Cristophe Aubé, Jean-Philippe Spano, Olivier Lucidarme, Aurélie Ferru, Jean-Pierre Tasu, Sylvain Manfredi, Aurore Bleuzen, Julie Léger, Thierry Lecomte
Purpose To evaluate changes in tumor vascularization parameters based on contrast-enhanced ultrasound (CEUS) quantification criteria of at least one visible liver metastasis as an early predictor of non-response to chemotherapy, including bevacizumab for colorectal cancer (CRC) liver metastases. Materials and Methods This multicenter prospective study included patients who received first-line bevacizumab-based chemotherapy. Tumor enhancement measured using CEUS within one liver metastasis and in relation to the surrounding healthy liver was quantified within 8 days before the first infusion of bevacizumab (E0), 24 hours after the end of the first infusion of bevacizumab (E1), in the 24 hours before the 2nd and 3 rd infusion of bevacizumab on day 15 (E2) and day 30 (E3), respectively, and after 2 months of treatment (E4)...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232723/biopsy-of-liver-target-lesions-under-contrast-enhanced-ultrasound-guidance-a-multi-center-study
#7
Giampiero Francica, Maria Franca Meloni, Ilario de Sio, Fulvia Terracciano, Eugenio Caturelli, Laura Riccardi, Paola Roselli, Maddalena Diana Iadevaia, Mariano Scaglione, Giovanni Lenna, Jason Chiang, Maurizio Pompili
Purpose To retrospectively characterize the prevalence and impact of contrast-enhanced ultrasound (CEUS) as a guidance technique for the biopsy of liver target lesions (LTLs) at six interventional ultrasound centers. Materials and Methods The six participating centers retrospectively selected all patients in whom biopsy needles were positioned in LTLs during CEUS. The prevalence of CEUS-guided biopsies at each center between 2005 and 2016, contrast agent consumption, procedure indications, diagnostic yield and complications were assessed...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232648/template-directed-fabrication-of-mil-101-cr-mesoporous-silica-composite-layer-packed-structure-and-enhanced-performance-for-co2-capture
#8
Chong Chen, Nengjie Feng, Qirui Guo, Zhong Li, Xue Li, Jing Ding, Lei Wang, Hui Wan, Guofeng Guan
A novel hybrid material constituted of MIL-101(Cr) and mesoporous silica was successfully assembled through an in-situ hydrothermal method. The MCM-41 with well-ordered mesopores acted as the structure-directing agent, which regulated the growth of MIL-101(Cr) crystals along a certain direction and restricted the expansion of framework. Meanwhile, the hydroxyl groups existed in MCM-41 preferentially coordinated with the Cr3+ centers in MOF, followed by the layer-packed arrangement of MIL-101(Cr) nanocrystals on the surface of matrix...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29232643/mechanical-corrosion-and-biocompatibility-behaviour-of-mg-3zn-ha-biodegradable-composites-for-orthopaedic-fixture-accessories
#9
Satish Jaiswal, R Manoj Kumar, Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
Development of biodegradable implants has grown into one of the important areas in medical science. Degradability becomes more important for orthopaedic accessories used to support fractured and damaged bones, in order to avoid second surgery for their removal after healing. Clinically available biodegradable orthopaedic materials are mainly made of polymers or ceramics. These orthopaedic accessories have an unsatisfactory mechanical strength, when used in load-bearing parts. Magnesium and its alloys can be suitable candidate for this purpose, due to their outstanding strength to weight ratio, biodegradability, non-toxicity and mechanical properties, similar to natural bone...
November 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29232614/evaluation-of-carbon-nanotube-based-copper-nanoparticle-composite-for-the-efficient-detection-of-agroviruses
#10
Muhammad Ali Tahir, Sadia Z Bajwa, Shahid Mansoor, Rob W Briddon, Waheed S Khan, Brian E Scheffler, Imran Amin
We report a biosensor that combines the construction of a three-dimensional nanocomposite with electrochemical methods for the detection of viruses in plants. This is the first report, where carbon nanotubes are used as a conductive frame to anchor highly electrolytic agglomerates of copper nanoparticles to detect agroviruses. Morphological analysis of nanocomposite revealed the presence of carbon nanotubes having a diameter of 50-100nm with copper nanoparticles of 20-100nm, attached in the form of bunches...
December 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29232609/influence-of-direct-and-sequential-extraction-methodology-on-metabolic-profiling
#11
K M Maria John, James Harnly, Devanand Luthria
A systematic comparison was made of the detected metabolite profiles for two plant materials (black beans and soybeans) and a dietary supplement (black cohosh) extracted using sequential (hexane, ethyl acetate, and 50% aqueous methanol) and direct extraction with three solvent systems (80% aqueous methanol, methanol/chloroform/water (2.5:1:1, v/v/v) and water). Extracts were analyzed by LC-MS (without derivatization) and GC-FID (with BSTFA/TMCS derivatizations). For sequential extraction, HPLC-UV and BSTFA/TMCS-derivatized GC-FID detection were more responsive to the polar molecules with a rough distribution of 10%, 10%, and 80% of the total signals in hexane, ethyl acetate, and 50% aqueous methanol, respectively...
December 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29232599/bioinspired-self-standing-macroporous-au-zno-sponges-for-enhanced-photocatalysis
#12
Ping She, Kongliang Xu, Shengyan Yin, Yinxing Shang, Qinrong He, Shan Zeng, Hang Sun, Zhenning Liu
A self-standing macroporous noble metal-zinc oxide (ZnO) sponge of robust 3D network has been fabricated through in-situ growth method. The key to the construction of the bioinspired sponge lies in the choice of commercial polyurethane sponge (CPS) with interconnected and junction-free macroporous structure as the skeleton to support Au/ZnO nanorods (Au/ZnONRs). The resultant Au/ZnO/CPS not only exhibits hierarchical structures representing physical features of CPS, but also demonstrates durable superior photocatalytic activity and hydrogen generation capability...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29232520/controlling-the-dynamic-instability-of-capped-metal-nanoparticles-on-metallic-surfaces
#13
Evangelina Laura Pensa, Tim Albrecht
Small metal nanoparticles (NPs) with core-sizes ranging from 1-3 nm constitute a bridge between molecules and colloids with unique electronic, catalytic and other properties. Many applications entail immobilization onto solid supports, but while NP behavior in solution is well studied, the effect of the interaction between NPs and the substrate surface is understood less. Here, we follow the structural evolution of thiolated monolayer-protected AuNPs on Au(111) substrates at the single-particle level in real-time using high-resolution in situ Scanning Tunneling Microscopy...
December 12, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29232508/programmable-payload-release-from-transient-polymer-microcapsules-triggered-by-a-specific-ion-co-activation-effect
#14
Shijia Tang, Liuyan Tang, Xiaocun Lu, Huiying Liu, Jeffrey S Moore
Stimuli-responsive materials activated by a pair of molecular or ionic species are of interest in the design of chemical logic gates and signal amplification schemes. There are relatively few ma-terials whose co-activated response has been well-characterized. Here, we demonstrate a specific ion co-activation (SICA) effect at the interfaces of transient polymer solids and liquid solu-tions. We found that depolymerization of the transient poly-mer, cyclic poly(phthalaldehyde) (cPPA), exhibited a SICA effect when the cPPA core-shell microcapsules were suspended in ion-containing acidic methanol solutions...
December 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29232505/installing-guest-molecules-at-specific-sites-within-scaffold-protein-crystals
#15
Thaddaus R Huber, Eli C McPherson, Carolyn E Keating, Christopher D Snow
Protein crystals are porous self-assembling materials that can be rapidly evolved by mutagenesis. We aimed to develop scaffold assisted crystallography techniques in an engineered protein crystal with large pores (>13 nm). Guest molecules were installed via a single covalent bond to attempt to reduce the conformational freedom and achieve high occupancy structures. We used 4 different conjugation strategies to attach guest molecules to 3 different cysteine sites within pre-existing protein crystals. In all but one case, the presence of the adduct was obvious in the electron density...
December 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29232495/encapsulation-of-homogeneous-catalysts-in-mesoporous-materials-using-diffusion-limited-atomic-layer-deposition
#16
Shufang Zhang, Bin Zhang, Haojie Liang, Yequn Liu, Yan Qiao, Yong Qin
The heterogenization of homogeneous metal complex catalysts has attracted great attention. Herein, we report the encapsulation of metal complexes into nanochannels of mesoporous materials by coating metal oxides at/near the pore entrance via diffusion-limited atomic layer deposition (ALD) to produce a "hollow plug". The pore size of the hollow plug is precisely controlled on the sub-nanometer scale by the number of ALD cycles to fit various metal complexes with different molecular sizes. Typically, Co or Ti complexes are successfully encapsulated into the nanochannels of SBA-15, SBA-16 and MCM-41...
December 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29232490/co2-to-terpenes-autotrophic-and-electroautotrophic-%C3%AE-humulene-production-with-cupriavidus-necator
#17
Thomas Krieg, Anne Sydow, Sonja Faust, Ina Huth, Dirk Holtmann
Herein, we demonstrate that CO2 can be converted by an engineered "Knallgas" bacterium (Cupriavidus necator) to the terpene α-humulene. Heterologous expression of the mevalonate pathway and α-humulene synthase resulted in a production of approx. 10 mg α-humulene per gram cell dry mass (CDM) under heterotrophic conditions. This first example of chemolithoautotrophic production of a terpene from carbon dioxide, hydrogen and oxygen is a promising starting point for the production of different high value terpene compounds from abundant and simple raw materials...
December 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29232417/evaluation-of-the-suitability-of-mitochondrial-dna-for-species-identification-of-microtraces-and-forensic-traces
#18
Małgorzata Natonek-Wiśniewska, Piotr Krzyścin
The objective of the study was to demonstrate how mitochondrial DNA (mtDNA) can be used to determine the species origin of animal microtraces. The study included pieces of cat and dog hair without the root, a fragment of cooked chicken bone (0.1g), three goose down samples (0.028 g), a pork swab, a pork scratching (5×5×5 mm), and pork lard (0.22 g). DNA was isolated from all of these samples using the method appropriate for the particular source material. The extracts had DNA concentration exceeding 5.4 ng/µl with A260/280 purity range of 1...
December 13, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29232392/experimental-and-numerical-study-of-the-failure-process-and-energy-mechanisms-of-rock-like-materials-containing-cross-un-persistent-joints-under-uniaxial-compression
#19
Rihong Cao, Ping Cao, Hang Lin, Xiang Fan
Joints and fissures in natural rocks have a significant influence on the stability of the rock mass, and it is often necessary to evaluate strength failure and crack evolution behavior. In this paper, based on experimental tests and numerical simulation (PFC2D), the macro-mechanical behavior and energy mechanism of jointed rock-like specimens with cross non-persistent joints under uniaxial loading were investigated. The focus was to study the effect of joint dip angle α and intersection angle γ on the characteristic stress, the coalescence modes and the energy release of jointed rock-like specimens...
2017: PloS One
https://www.readbyqxmd.com/read/29232358/genetic-polymorphisms-of-insulin-like-growth-factor-1-are-associated-with-osteosarcoma-risk-and-prognosis
#20
Jianshui Mao, Genying Zhuang, Zhikang Chen
BACKGROUND Insulin-like growth factor 1 (IGF-1) gene plays an important role in bone and soft tumors. IGF-1 gene polymorphisms have been revealed to be correlated with the carcinogenesis and progression of solid malignancies. We therefore hypothesized that IGF-1 genetic polymorphisms might be associated with the risks and outcomes of osteosarcomas in Chinese individuals. MATERIAL AND METHODS This study included 173 conventional osteosarcoma individuals and 175 tumor-free controls. Five single nucleotide polymorphisms (SNPs) of IGF-1 (rs6214, rs6218, rs35767, rs5742612, and rs5742714) were genotyped...
December 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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