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https://www.readbyqxmd.com/read/29055285/delayed-spontaneous-resorption-of-lumbar-intervertebral-disc-herniation-a-case-report
#1
You Jin Jung, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, In-Hyuk Ha
Background • Large intervertebral disc herniation is often managed with surgery, but it is not uncommon for spontaneous resorption of herniated disc material to occur. Although the majority of spontaneous disc resorption occurs in the acute phase, an unusual case of delayed intervertebral disc regression at 18 mo postonset is presented. Case Presentation • A 32-y-old female patient presented with acute low-back pain and pain in both legs a Korean medicine hospital specializing in spinal disorders. Massive intervertebral disc herniation was found on lumbar magnetic resonance imaging (MRI), and inguinal and genital pain and numbness was suggestive of risk of cauda equina syndrome...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055266/geographical-inequalities-in-health-in-a-time-of-austerity-baseline-findings-from-the-stockton-on-tees-cohort-study
#2
R Bhandari, A Kasim, J Warren, N Akhter, C Bambra
Stockton-on-Tees has the highest geographical inequalities in health in England with the life expectancy at birth gap between the most and deprived neighbourhoods standing at over 17 years for men and 11 years for women. In this study, we provide the first detailed empirical examination of this geographical health divide by: estimating the gap in physical and general health (as measured by EQ. 5D, EQ. 5D-VAS and SF8PCS) between the most and least deprived areas; using a novel statistical technique to examining the causal role of compositional and contextual factors and their interaction; and doing so in a time of economic recession and austerity...
October 18, 2017: Health & Place
https://www.readbyqxmd.com/read/29055265/input-of-different-kinds-of-soluble-pectin-to-cation-binding-properties-of-roots-cell-walls
#3
A Szatanik-Kloc, J Szerement, J Cybulska, G Jozefaciuk
It is widely believed that pectin are responsible for the vast majority of cation binding positions in the root cell walls. To estimate the role of particular kinds of pectin, we studied the cell wall material isolated from the roots of monocots (wheat and rye) and dicots (clover and lupine) before and after removal of different fractions of soluble pectin. Simultaneously PME activity and degree of pectin methylation were determined. From potentiometric titration curves cation exchange capacity, total surface charge and acidic strength of surface functional groups responsible for surface charging were determined...
October 16, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#4
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055245/biomechanical-analysis-of-an-interference-screw-and-a-novel-twist-lock-screw-design-for-bone-graft-fixation
#5
S Asnis, J Mullen, P D Asnis, N Sgaglione, T LaPorta, D A Grande, N O Chahine
BACKGROUND: Malpositioning of an anterior cruciate ligament graft during reconstruction can occur during screw fixation. The purpose of this study is to compare the fixation biomechanics of a conventional interference screw with a novel Twist Lock Screw, a rectangular shaped locking screw that is designed to address limitations of graft positioning and tensioning. METHODS: Synthetic bone (10, 15, 20lb per cubic foot) were used simulating soft, moderate, and dense cancellous bone...
October 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29055195/antifouling-aptasensor-for-the-detection-of-adenosine-triphosphate-in-biological-media-based-on-mixed-self-assembled-aptamer-and-zwitterionic-peptide
#6
Guixiang Wang, Xiaoli Su, Qingjun Xu, Guiyun Xu, Jiehua Lin, Xiliang Luo
Direct detection of targets in complex biological media with conventional biosensors is an enormous challenge due to the nonspecific adsorption and severe biofouling. In this work, a facile strategy for sensitive and low fouling detection of adenosine triphosphate (ATP) is developed through the construction of a mixed self-assembled biosensing interface, which was composed of zwitterionic peptide (antifouling material) and ATP aptamer (bio-recognition element). The peptide and aptamer (both containing thiol groups) were simultaneously self-assembled onto gold electrode surface electrodeposited with gold nanoparticles...
October 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055179/nigella-sativa-oil-protects-the-rat-ovary-from-oxidative-injury-due-to-ischemia-reperfusion
#7
Melahat Atasever, Zeyneb Bakacak
BACKGROUND The aim of this study was to evaluate the effects of Nigella sativa (N. sativa) oil (NSO) on ovarian oxidative damage following ischemia-reperfusion injury, using a rat model of ovarian torsion. MATERIAL AND METHODS Forty-eight female albino Wistar rats were divided into six groups: (Group 1) laparotomy only; (Group 2) intraperitoneal NSO (2 ml/kg), 1 hour following laparotomy; (Group 3) 3 hours of ovarian ischemia; (Group 4) 3 hours of ovarian ischemia followed by 3 hours of reperfusion; (Group 5) 3 hours of ovarian ischemia and 2 ml/kg of NSO 1 hour before laparotomy; (Group 6) 3 hours of reperfusion after 3 hours of ovarian ischemia and 2 ml/mg of NSO 1 hour before laparotomy...
October 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29055138/effects-of-a-bone-graft-substitute-consisting-of-porous-gradient-ha-zro2-and-gelatin-chitosan-slow-release-hydrogel-containing-bmp-2-and-bmscs-on-lumbar-vertebral-defect-repair-in-rhesus-monkey
#8
Rong-Xue Shao, Ren-Fu Quan, Tuo Wang, Wei-Bin Du, Gao-Yong Jia, Dong Wang, Long-Bao Lv, Cai-Yin Xu, Xi-Cheng Wei, Jin-Fu Wang, Di-Sheng Yang
Dense biomaterial plays an important role in bone replacement. However, it fails to induce bone-cell migration into graft material. In the present study, a novel bone-graft substitute (BGS) consisting of porous gradient HA/ZrO2 composite (PGHC) and gelatin/chitosan slow-release hydrogel containing BMP-2 and BMSCs was designed and prepared to repair lumbar vertebral defects. The morphological characteristics of the BGS evaluated by scanning electron microscope showed that it had a three-dimensional network structure with uniformly distributed chitosan microspheres on the surfaces of the graft material and the interior of the pores...
October 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29055127/shoe-floor-interactions-in-human-walking-with-slips-modeling-and-experiments
#9
Mitja Trkov, Jingang Yi, Tao Liu, Kang Li
Shoe-floor interactions play a crucial role in determining the possibility of potential slip and fall during human walking. Biomechanical and tribological parameters influence the friction characteristics between the shoe sole and the floor and the existing work mainly focus on experimental studies. In this paper, we present modeling, analysis, and experiments to understand slip and force distributions between the shoe sole and floor surface during human walking. We present results for both soft and hard sole material...
October 21, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29055113/accelerating-patient-access-to-novel-biologics-using-stable-pool-derived-product-for-non-clinical-studies-and-single-clone-derived-product-for-clinical-studies
#10
Trent P Munro, Kim Le, Huong Le, Li Zhang, Jennitte Stevens, Neil Soice, Sabrina A Benchaar, Robert W Hong, Chetan T Goudar
Cell cloning and subsequent process development activities are on the critical path directly impacting the timeline for advancement of next generation therapies to patients with unmet medical needs. The use of stable cell pools for early stage material generation and process development activities is an enabling technology to reduce timelines. To successfully use stable pools during development, it is important that bioprocess performance and requisite product quality attributes be comparable to those observed from clonally derived cell lines...
October 21, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29055040/the-concise-guide-to-pharmacology-2017-18-g-protein-coupled-receptors
#11
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055039/the-concise-guide-to-pharmacology-2017-18-other-ion-channels
#12
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055038/the-concise-guide-to-pharmacology-2017-18-ligand-gated-ion-channels
#13
Stephen Ph Alexander, John A Peters, Eamonn Kelly, Neil V Marrion, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055037/the-concise-guide-to-pharmacology-2017-18-overview
#14
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055036/the-concise-guide-to-pharmacology-2017-18-catalytic-receptors
#15
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055035/the-concise-guide-to-pharmacology-2017-18-transporters
#16
Stephen Ph Alexander, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055034/the-concise-guide-to-pharmacology-2017-18-enzymes
#17
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055033/the-concise-guide-to-pharmacology-2017-18-voltage-gated-ion-channels
#18
Stephen Ph Alexander, Jörg Striessnig, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055032/the-concise-guide-to-pharmacology-2017-18-nuclear-hormone-receptors
#19
Stephen Ph Alexander, John A Cidlowski, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website...
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29055024/serum-lipid-vitamin-d-levels-and-obesity-in-perimenopausal-and-postmenopausal-women-in-non-manual-employment
#20
Jarosław Pinkas, Iwona Bojar, Mariusz Gujski, Joanna Bartosińska, Alfred Owoc, Dorota Raczkiewicz
BACKGROUND Increasing age, increased body mass index (BMI), and abnormal lipid profiles contribute to an increased risk of vitamin D deficiency. Women who have a perimenopausal and postmenopausal reduction in estrogen levels are a high-risk group for vitamin D deficiency. The aims of this study were to compare the serum vitamin D levels, lipid profile, and BMI between perimenopausal and postmenopausal women in non-manual employment, and to determine whether there were any interdependent factors. MATERIAL AND METHODS Three hundred women in non-manual employment, aged between 44-66 years, were divided into three groups: early perimenopausal; late perimenopausal; and postmenopausal...
October 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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