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https://www.readbyqxmd.com/read/27570419/management-of-gastric-and-duodenal-neuroendocrine-tumors
#1
REVIEW
Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27330538/liver-metastasis-of-gastrointestinal-neuroendocrine-tumors-a-single-center-experience
#2
Bita Geramizadeh, Ali Kashkooe, Seyed Ali Malekhosseini
BACKGROUND: Gastrointestinal neuroendocrine tumors (GI-NETs) are potentially malignant tumors, and their most common location of metastasis is the liver. OBJECTIVES: In this report, we will describe our experience with some clinical and pathologic findings of hepatic metastasis in a group of cases of GI-NETs at the largest referral center of GI and liver diseases in south Iran. MATERIALS AND METHODS: In this four-year study (2011 - 2014), all GI and liver NETs were extracted from the pathology files of hospitals affiliated with Shiraz University of Medical Sciences...
May 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27236421/diagnosis-and-management-of-gastrointestinal-neuroendocrine-tumors-an-evidence-based-canadian-consensus
#3
REVIEW
Simron Singh, Sylvia L Asa, Chris Dey, Hagen Kennecke, David Laidley, Calvin Law, Timothy Asmis, David Chan, Shereen Ezzat, Rachel Goodwin, Ozgur Mete, Janice Pasieka, Juan Rivera, Ralph Wong, Eva Segelov, Daniel Rayson
The majority of neuroendocrine tumors originate in the digestive system and incidence is increasing within Canada and globally. Due to rapidly evolving evidence related to diagnosis and clinical management, updated guidance on the diagnosis and treatment of gastrointestinal neuroendocrine tumors (GI-NETs) are of clinical importance. Well-differentiated GI-NETs may exhibit indolent clinical behavior and are often metastatic at diagnosis. Some NET patients will develop secretory disease requiring symptom control to optimize quality of life and clinical outcomes...
June 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27082572/effectiveness-of-endoscopic-treatment-for-gastrointestinal-neuroendocrine-tumors-a-retrospective-study
#4
Weili Sun, Siyuan Wu, Xiao Han, Chuanhua Yang
Several recent studies have explored efficacy and safety of different endoscopic treatments for gastrointestinal neuroendocrine tumors (GI-NETs). However, there is no definitive consensus regarding the best endoscopic approach for GI-NETs treatment. Therefore, the present study was conducted to investigate the application of various endoscopic techniques for the treatment of GI-NETs according to the previous conclusions and to summarize the optimal endoscopic modalities for GI-NETs. Ninety-eight patients with 100 GI-NETs removed by endoscopic therapies were reviewed...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27033797/-diagnostic-analysis-for-52-cases-of-gastrointestinal-neuroendocrine-tumor
#5
Yi'nan Wang, Yuan Zhou, Heli Liu, Haiping Pei
OBJECTIVE: To investigate the clinical features, diagnosis, treatments and prognosis for gastrointestinal neuroendocrine tumors (GI-NETs).
 METHODS: Clincal data of 52 patients, who were diagnosed as GI-NETs between January 2004 and October 2014, were reviewed. The patients were divided into a local excision group (n=21) and a transabdominal excision group (n=30), and the major clinical features, treatment modalities and outcomes were analyzed.
 RESULTS: The clinical features of GI-NETs were nonspecific, and most of the clinical manifestation were local invasiveness...
March 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/26805636/high-vegf-serum-values-are-associated-with-locoregional-spread-of-gastroenteropancreatic-neuroendocrine-tumors-gep-nets
#6
Maja Cigrovski Berković, Tamara Čačev, Tina Catela Ivković, Jasminka Marout, Monika Ulamec, Vanja Zjačić-Rotkvić, Sanja Kapitanović
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascularized neoplasms, capable of synthethisizing VEGF-A, a key mediator of angiogenesis. In pancreatic neuroendocrine tumors (pNETs) VEGF expression is higher in benign and low-grade tumors and associated with good prognosis (neuroendocrine paradox) while the VEGF role in gastrointestinal NETs (GI-NETs) is still unclear. In this study, we examined the VEGF-1154A/G polymorphism in 145 GEP-NET patients and 150 controls. Next, we measured VEGF serum levels and VEGF tumor protein expression, comparing it with Ki67 and tumor grade...
April 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26643525/gastrointestinal-neuroendocrine-tumors-searching-the-optimal-treatment-strategy-a-literature-review
#7
REVIEW
Rossana Berardi, Silvia Rinaldi, Mariangela Torniai, Francesca Morgese, Stefano Partelli, Miriam Caramanti, Azzurra Onofri, Vanessa Polenta, Silvia Pagliaretta, Massimo Falconi, Stefano Cascinu
Neuroendocrine tumors of the gastro-entero-pancreatic system (GEP-NETs) are a heterogeneous group of neoplasms, with different malignant potential and behavior. Many treatment options are available. Surgery should be considered for localized tumors and in some selected cases of metastatic disease. Somatostatin analogs, useful for symptoms control in functioning tumors, are also effective to inhibit tumor progression in specific settings. The multi-TKI sunitinib and of the mTOR-inhibitor everolimus are efficacy for metastatic pancreatic NET (P-NET) treatment...
February 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26614377/hepatic-directed-therapies-in-patients-with-neuroendocrine-tumors
#8
REVIEW
Andrew S Kennedy
Neuroendocrine tumors (NETs) of the gastrointestinal (GI) tract have a propensity for producing hepatic metastases. Most GI NETs arise from the foregut or midgut, are malignant, and can cause severe debilitating symptoms adversely affecting quality of life. Aggressive treatments to reduce symptoms have an important role in therapy. Patients with GI NETs usually present with inoperable metastatic disease and severe symptoms from a variety of hormones and biogenic amines. This article describes intra-arterial hepatic-directed therapies for metastases from NETs, a group of treatments in which the therapeutic and/or embolic agents are released intra-arterially in specific hepatic vessels to target tumors...
February 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/26447612/the-axon-guidance-molecule-semaphorin-3f-is-a-negative-regulator-of-tumor-progression-and-proliferation-in-ileal-neuroendocrine-tumors
#9
Julien Bollard, Patrick Massoma, Cécile Vercherat, Martine Blanc, Florian Lepinasse, Nicolas Gadot, Christophe Couderc, Gilles Poncet, Thomas Walter, Marie-Odile Joly, Valérie Hervieu, Jean-Yves Scoazec, Colette Roche
Gastro-intestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, frequently metastatic, raising difficult clinical and therapeutic challenges due to a poor knowledge of their biology. As neuroendocrine cells express both epithelial and neural cell markers, we studied the possible involvement in GI-NETs of axon guidance molecules, which have been shown to decrease tumor cell proliferation and metastatic dissemination in several tumor types. We focused on the role of Semaphorin 3F (SEMA3F) in ileal NETs, one of the most frequent subtypes of GI-NETs...
November 3, 2015: Oncotarget
https://www.readbyqxmd.com/read/26369680/aspirin-use-on-incidence-and-mortality-of-gastrointestinal-cancers-current-state-of-epidemiological-evidence
#10
REVIEW
Wen-Kuan Huang, Hui-Tzu Tu, Lai-Chu See
Aspirin has been one of the most widely used medications since its first synthesis more than 100 years ago. In addition to short-term use for pain and fever relief, regular use of aspirin has been shown to reduce the risk of cardiovascular diseases and strokes. The issue of regular aspirin use in cancer prevention is definitely promising, which has been supported by growing evidence from a number of observational studies and post-trial follow-up data. Among all cancers, aspirin is showing to be the most effective in reducing the risk of colorectal cancer, and even at lower doses demonstrates a 30-40% effectiveness in preventing colorectal cancer...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26369265/combination-of-laparoscopic-and-endoscopic-approaches-to-neoplasia-with-non-exposure-technique-clean-net-for-gist-with-ulceration
#11
Kazuhito Nabeshima, Mifuji Tomioku, Kenji Nakamura, Seiei Yasuda
Combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET) was developed to avoid intraoperative tumor dissemination. We report two cases of gastric gastrointestinal stromal tumor (GIST) with ulceration surgically treated with CLEAN-NET at our institution. The first case was a 55-year-old male with hematemesis. Gastric endoscopy revealed a gastric GIST with ulceration of the fornix. CLEAN-NET was performed with the insertion of five trocars and a liver retractor...
September 2015: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/26360914/dna-methylation-profiles-distinguish-different-subtypes-of-gastroenteropancreatic-neuroendocrine-tumors
#12
Alexandre How-Kit, Emelyne Dejeux, Bertrand Dousset, Victor Renault, Marion Baudry, Benoit Terris, Jörg Tost
AIM: Most studies have considered gastroenteropancreatic neuroendocrine tumors (GEP-NETs) as a homogenous group of samples or distinguish only gastrointestinal from pancreatic endocrine tumors. This article investigates if DNA methylation patterns could distinguish subtypes of GEP-NETs. MATERIALS & METHODS: The DNA methylation level of 807 cancer-related genes was investigated in insulinomas, gastrinomas, non-functioning pancreatic endocrine tumors and small intestine endocrine tumors...
2015: Epigenomics
https://www.readbyqxmd.com/read/26356731/risk-and-protective-factors-for-small-intestine-neuroendocrine-tumors-a-prospective-case-control-study
#13
Maria Rinzivillo, Gabriele Capurso, Davide Campana, Nicola Fazio, Francesco Panzuto, Francesca Spada, Noemi Cicchese, Stefano Partelli, Paola Tomassetti, Massimo Falconi, Gianfranco Delle Fave
BACKGROUND: The incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, but few studies have investigated risk factors for their occurrence, suggesting that family history (FH) of any cancer, smoking and previous cholecystectomy are associated with an increased risk. Such studies investigated small series or examined cancer registries without direct interviews. AIM: We therefore aimed at clarifying risk and protective factors for the occurrence of sporadic SI-NETs...
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26308522/identifying-the-critical-domain-of-ll-37-involved-in-mediating-neutrophil-activation-in-the-presence-of-influenza-virus-functional-and-structural-analysis
#14
Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn
The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection. We recently showed that LL-37 increases neutrophil respiratory burst and neutrophil extracellular trap (NET) responses to IAV through engaging formyl peptide receptor 2 (FPR-2). In this paper we show that a fragment of LL-37, GI-20, which is composed of the central helical segment of the peptide, has similar effects as LL-37 on neutrophil activation...
2015: PloS One
https://www.readbyqxmd.com/read/26303717/other-novel-therapies-biomarkers-micrornas-and-microrna-inhibitors-dna-methylation-epigenetics-immunotherapy-and-virotherapy
#15
REVIEW
Valeria Giandomenico, Chrissie Thirlwell, Magnus Essand
Neuroendocrine tumors (NETs) consist of heterogeneous neoplasms. The neuroendocrine cells of the human body are confined to certain organs, such as the thyroid, pancreas and adrenals, or they are dispersed throughout the body in the respiratory tract and in the intestinal mucosa. The cells belong to the diffuse endocrine cell system, share a neuroendocrine phenotype, and accumulate precursor molecules which are then processed into hormones, peptides or amines. The tightly controlled release on stimulation is either to the blood stream or adjacent cells or neurons...
2015: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/26297843/antidiarrheal-activity-of-cashew-gum-a-complex-heteropolysaccharide-extracted-from-exudate-of-anacardium-occidentale-l-in-rodents
#16
Thiago S L Araújo, Douglas S Costa, Nayara A Sousa, Luan K M Souza, Simone de Araújo, Ana Patrícia Oliveira, Francisca Beatriz M Sousa, Durcilene A Silva, André L R Barbosa, José Roberto S A Leite, Jand Venes R Medeiros
ETHNOPHARMACOLOGICAL RELEVANCE: Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. AIM OF THE STUDY: The primary aim of the present study is to evaluate the antidiarrheal activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models...
November 4, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26259135/succinate-dehydrogenase-sdh-deficient-pancreatic-neuroendocrine-tumor-expands-the-sdh-related-tumor-spectrum
#17
Nicolasine D Niemeijer, Thomas G Papathomas, Esther Korpershoek, Ronald R de Krijger, Lindsey Oudijk, Hans Morreau, Jean-Pierre Bayley, Frederik J Hes, Jeroen C Jansen, Winand N M Dinjens, Eleonora P M Corssmit
CONTEXT: Mutations in genes encoding the subunits of succinate dehydrogenase (SDH) can lead to pheochromocytoma/paraganglioma formation. However, SDH mutations have also been linked to nonparaganglionic tumors. OBJECTIVE: The objective was to investigate which nonparaganglionic tumors belong to the SDH-associated tumor spectrum. DESIGN: This was a retrospective cohort study. SETTING: The setting was a tertiary referral center...
October 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26256906/gastrointestinal-neuroendocrine-tumor-with-unresectable-liver-metastases-an-example-of-multimodal-therapeutic-approach
#18
Jorge Martínez, Santiago Besa, Juan P Arab, Juan C Quintana, Carlos Regonesi, Alvaro Huete, Nicolás Jarufe, Juan F Guerra, Carlos Benítez, Marco Arrese
Gastrointestinal neuroendocrine tumors (NET) frequently present with unresectable hepatic metastases, which poses a barrier for curative treatment. Resection of the primary tumor and subsequent orthotopic liver transplantation (OLT) has been proposed as a treatment approach but available data in this regard is limited. We present a clinical case of an otherwise asymptomatic 44-yo man complaining of abdominal pain and dyspepsia that was diagnosed of a 10 cm duodenal tumor with multiple hepatic metastases. A CT-guided biopsy confirmed a NET...
September 2015: Annals of Hepatology
https://www.readbyqxmd.com/read/26234557/use-of-non-vitamin-k-antagonist-oral-anticoagulants-in-atrial-fibrillation-patients-insights-from-a-specialist-atrial-fibrillation-clinic
#19
S I Lee, M Sayers, G Y H Lip, D A Lane
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are broadly preferable to vitamin K antagonists (VKAs) for stroke prevention in non-valvular atrial fibrillation (AF) given their overall net clinical benefit. We report an audit of the profile of OAC usage and adverse events in patients attending a specialist AF clinic. METHODS: Patients attending our specialist AF clinic who were commenced on NOACs for SPAF between January 2013 and August 2014 were included and electronic medical records were retrospectively reviewed between August 2014 and November 2014, to collect demographic, clinical and outcome data...
November 2015: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/26207162/hepatic-metastatic-disease-in-pediatric-and-adolescent-solid-tumors
#20
Israel Fernandez-Pineda, John A Sandoval, Andrew M Davidoff
The management of hepatic metastatic disease from solid tumors in adults has been extensively described and resection of metastatic liver lesions from colorectal adenocarcinoma, renal adenocarcinoma, breast cancer, testicular cancer, and neuroendocrine tumors (NET) have demonstrated therapeutic benefits in select patients. However, there are few reports in the literature on the management of hepatic metastatic disease in the pediatric and adolescent populations and the effectiveness of hepatic metastasectomy...
July 18, 2015: World Journal of Hepatology
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