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https://www.readbyqxmd.com/read/28213771/a-novel-spiroindoline-targets-cell-cycle-and-migration-via-modulation-of-microtubule-cytoskeleton
#1
Naveen Kumar, Santanu Hati, Parthapratim Munshi, Subhabrata Sen, Seema Sehrawat, Shailja Singh
Natural product-inspired libraries of molecules with diverse architectures have evolved as one of the most useful tools for discovering lead molecules for drug discovery. In comparison to conventional combinatorial libraries, these molecules have been inferred to perform better in phenotypic screening against complicated targets. Diversity-oriented synthesis (DOS) is a forward directional strategy to access such multifaceted library of molecules. From a successful DOS campaign of a natural product-inspired library, recently a small molecule with spiroindoline motif was identified as a potent anti-breast cancer compound...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28209268/inorganic-mercury-prevents-the-differentiation-of-sh-sy5y-cells-amyloid-precursor-protein-microtubule-associated-proteins-and-ros-as-potential-targets
#2
Miguel Chin Chan, Elizabeth Bautista, Isabel Alvarado-Cruz, Betzabet Quintanilla-Vega, José Segovia
Exposure to mercury (Hg) occurs through different pathways and forms including methylmecury (MeHg) from seafood and rice, ethylmercury (EtHg), and elemental Hg (Hg(0)) from dental amalgams and artisanal gold mining. Once in the brain all these forms are transformed to inorganic Hg (I-Hg), where it bioaccumulates and remains for long periods. Hg is a well-known neurotoxicant, with its most damaging effects reported during brain development, when cellular key events, such as cell differentiation take place. A considerable number of studies report an impairment of neuronal differentiation due to MeHg exposure, however the effects of I-Hg, an important form of Hg found in brain, have received less attention...
February 6, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28185368/alkyl-hetero-aryl-bond-formation-via-decarboxylative-cross-coupling-a-systematic-analysis
#3
Frederik Sandfort, Matthew J O'Neill, Josep Cornella, Laurin Wimmer, Phil S Baran
Suzuki, Negishi, and Kumada couplings are some of the most important reactions for the formation of skeletal C-C linkages. Their widespread use to forge bonds between two aromatic rings has enabled every branch of chemical science. The analogous union between alkyl halides and metallated aryl systems has not been as widely employed due to the lack of commercially available halide building blocks. Redox-active esters have recently emerged as useful surrogates for alkyl halides in cross-coupling chemistry. Such esters are easily accessible through reactions between ubiquitous carboxylic acids and coupling agents widely used in amide bond formation...
February 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28179959/plasmonic-detection-of-mercury-via-amalgam-formation-on-surface-immobilized-single-au-nanorods
#4
Carola Schopf, Alfonso Martín, Daniela Iacopino
Au nanorods were used as plasmonic transducers for investigation of mercury detection through a mechanism of amalgam formation at the nanorod surfaces. Marked scattering color transitions and associated blue shifts of the surface plasmon resonance peak wavelengths (λmax) were measured in individual nanorods by darkfield microscopy upon chemical reduction of Hg(II). Such changes were related to compositional changes occurring as a result of Hg-Au amalgam formation as well as morphological changes in the nanorods' aspect ratios...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28179282/the-gata-factor-revolution-in-hematology
#5
Koichi R Katsumura, Emery H Bresnick
The discovery of the GATA transcription factor family revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our understanding of how hematopoietic stem and progenitor cells (HSPCs) develop from precursors, how progenitors generate red blood cells, how hemoglobin synthesis is regulated, and the molecular underpinnings of non-malignant and malignant hematologic disorders. This thrilling journey began with mechanistic studies on a β-globin enhancer- and promoter-binding factor, GATA-1, the founding member of the GATA family...
February 8, 2017: Blood
https://www.readbyqxmd.com/read/28168544/the-urban-dental-index-a-method-for-measuring-and-mapping-dental-health-disparities-across-urban-areas
#6
Emily Coles, Estie Kruger, Abed Aktam Anjrini, Marc Tennant
The aim of this study was to create an Urban Dental Index (UDI) for Perth, Western Australia, adapting a method utilised by the World Health Organisation. Dental health indicators were derived from the 2011 census, standardised on a (0,1) interval, amalgamated using a geometric mean, and mapped to identify dental health inequity. The validity of the UDI was tested by comparison with oral cellulitis data. Dental health disparities were examined using a ratio of the mean of the highest to lowest decile and slope of the eight middle deciles...
February 6, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28167171/professional-ballet-dancers-experience-of-injury-and-osteopathic-treatment-in-the-uk-a-qualitative-study
#7
Tobias Pollard-Smith, Oliver P Thomson
OBJECTIVES: Professional dancers suffer significant musculoskeletal injuries during the course of their careers. Treatment-seeking behaviour is important in all patient populations, yet is rarely investigated amongst professional dancers. This qualitative study aimed to form a better understanding of how dancers decide to seek treatment, and in particular to explore their experiences of receiving osteopathic care for their injuries. METHODS: A qualitative study design using grounded theory was used as a methodological framework for data collection and analysis...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28149467/effect-of-dental-restorative-materials-on-total-antioxidant-capacity-and-calcium-concentration-of-unstimulated-saliva
#8
Gholam H Ramezani, Mona-Momeni Moghadam, Mohammad-Ali Saghiri, Franklin Garcia-Godoy, Armen Asatourian, Mohsen Aminsobhani, Mark Scarbecz, Nader Sheibani
BACKGROUND: To evaluate the effect of dental amalgam and composite restorations on total antioxidant capacity (TAC) and calcium (Ca) ion concentration of unstimulated saliva. MATERIAL AND METHODS: Forty-eight children aged 6-10 years selected and divided into three groups of sixteen (8 males, 8 females). In group A and B, samples consisted of two class II dental composite or amalgam restorations, while in group C samples were caries-free (control group). Unstimulated saliva from all samples was collected and TAC was measured by spectrophotometry using an adaptation of 2, 2'-azino-di-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) assay...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28134970/allergen-getriggerte-lichenoide-mundschleimhautl%C3%A3-sionen-diagnose-und-therapie-anhand-eines-fallbeispiels
#9
Constanze Olms, Torsten W Remmerbach
Allergen-triggered lichenoid oral mucosa lesions may occur both in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Clinically, OLP and OLL are difficult to distinguish from each other. An OLP should be checked by histological examination. Therefore all patients with OLP should be included into a close control interval due to the the potential malignant transformation, whereas in the literature a higher risk of malignancy is attributed to OLL in comparison with OLP. Based on a clinical case, it is demonstrated that an interdisciplinary approach in allergy and mucous diagnosis is necessary to verify the correaltion between a contact allergy to amalgam and the lichenoid mucosal lesions...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28130742/assessment-of-mercury-intake-from-fish-meals-based-on-intervention-research-in-the-polish-subpopulation
#10
Renata Kuras, Beata Janasik, Magdalena Stanislawska, Lucyna Kozlowska, Wojciech Wasowicz
The paper's objective was to estimate weekly Hg intake from fish meals based on intervention research. Total Hg (THg) concentrations in blood and hair samples collected from men (n = 67) from an intervention study as well as muscular tissues of fresh and after heat-treating fish were determined using the thermal decomposition amalgamation atomic absorption spectrometry method (TDA-AAS) using direct mercury analyzer (DMA-80). The mean of the estimated weekly intake (EWI) was estimated at 0.62 μg/kg bw/week in the range 0...
January 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28118192/novel-treatment-planning-of-hemimandibular-hyperplasia-by-the-use-of-three-dimensional-computer-aided-design-and-computer-aided-manufacturing-technologies
#11
Muhanad M Hatamleh, Elizabeth Yeung, Jonas Osher, Chrisopher Huppa
RATIONALE AND AIM: Hemimandibular hyperplasia is characterized by an obvious overgrowth in the size of the mandible on one side, which can extend up to the midline causing facial asymmetry. Surgical resection of the overgrowth depends heavily on the skill and experience of the surgeon. This report describes a novel methodology of applying three-dimensional computer-aided-design and computer-aided-manufacturing principles in improving the outcome of surgery in 2 mandibular hyperplasia patients...
January 23, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28111155/the-effects-of-different-restorative-materials-on-the-detection-of-approximal-caries-in-cone-beam-computed-tomography-scans-with-and-without-metal-artifact-reduction-mode
#12
Fatma Cebe, Ali Murat Aktan, Abdul Semih Ozsevik, Mehmet Ertugrul Ciftci, Hatice Derya Surmelioglu
OBJECTIVES: The aim of this study was to investigate the influence of artifacts produced by different restorative materials on the detection of approximal caries in cone-beam computed tomography (CBCT) scans with and without the application of an artifact-reduction (AR) option. STUDY DESIGN: Ninety-eight noncavitated premolar and molar teeth were placed with approximal contacts consisting of 2 sound or carious teeth and 1 mesial-occlusal-distal restored tooth with resin-modified glass-ionomer cement (RMGIC), amalgam, composite, ceramic-based composite (CBC), or computer-aided design-computer-aided manufacturing (CAD-CAM) zirconia materials in between...
March 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28103053/mercury-amalgam-diffusion-in-human-teeth-probed-using-femtosecond-libs
#13
Liciane Toledo Bello, Patricia Aparecida da Ana, Dário Santos, Francisco José Krug, Denise Maria Zezell, Nilson Dias Vieira, Ricardo Elgul Samad
In this work the diffusion of mercury and other elements from amalgam tooth restorations through the surrounding dental tissue (dentin) was evaluated using femtosecond laser-induced breakdown spectroscopy (fs-LIBS). To achieve this, seven deciduous and eight permanent extracted human molar teeth with occlusal amalgam restorations were half-sectioned and analyzed using pulses from a femtosecond laser. The measurements were performed from the amalgam restoration along the amalgam/dentin interface to the apical direction...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28097107/surgical-resection-of-localized-hepatocellular-carcinoma-patient-selection-and-special-consideration
#14
REVIEW
Ka Wing Ma, Tan To Cheung
Localized hepatocellular carcinoma (HCC) refers to a solitary or few tumors located within either the left or right hemiliver without evidence of bilobar or extrahepatic spread. This term encompasses a heterogeneous morphology with no regard to stage of prognosis of the disease. Surgical resection remains the mainstay of curative treatment for the localized HCC. Various biochemical and radiological tests constitute an indispensible part of preoperative assessment. Emergence of laparoscopic hepatectomy has brought liver resection into a new era...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28093013/long-term-changes-in-health-complaints-after-removal-of-amalgam-restorations
#15
Lars Björkman, Therese T Sjursen, Knut Dalen, Gunvor B Lygre, Trine Lise L Berge, Johanna Svahn, Birgitte F Lundekvam
OBJECTIVE: Concerns over adverse effects of mercury released from dental amalgam sometimes lead patients to request removal of their amalgam restorations. Several studies report improvement of subjective health after removal of amalgam restorations, but the mechanisms are unclear. The aim of this paper is to present data on long term changes in intensity of health complaints after amalgam removal in a group of patients with health complaints self-attributed to dental amalgam. Data from the five years follow-up in a clinical trial are presented and related to potential determinants of change...
January 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28089512/paleozoic-nymphal-wing-pads-support-dual-model-of-insect-wing-origins
#16
Jakub Prokop, Martina Pecharová, André Nel, Thomas Hörnschemeyer, Ewa Krzemińska, Wiesław Krzemiński, Michael S Engel
The appearance of wings in insects, early in their evolution [1], has been one of the more critical innovations contributing to their extraordinary diversity. Despite the conspicuousness and importance of wings, the origin of these structures has been difficult to resolve and represented one of the "abominable mysteries" in evolutionary biology [2]. More than a century of debate has boiled the matter down to two competing alternatives-one of wings representing an extension of the thoracic notum, the other stating that they are appendicular derivations from the lateral body wall...
January 23, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28081557/student-led-intervention-to-innovate-hand-hygiene-practice-in-auckland-region-s-medical-students-the-no-hharms-study
#17
Nathanael Cc Lucas, Carl G Hume, Abdal Al-Chanati, William Diprose, Sally Roberts, Josh Freeman, Vernon Mogol, David Hoskins, Richard Hamblin, Chris Frampton, Warwick Bagg, Alan F Merry
BACKGROUND: Hand hygiene is important in reducing healthcare-associated infections. The World Health Organization has defined 'five moments' when hand hygiene compliance is required. During 2013, New Zealand national data showed poor compliance with these moments by medical students. AIM: To improve medical students' compliance with the five moments. METHODS: In this prospective student-led quality improvement initiative, student investigators developed, implemented and evaluated a multi-modal intervention comprising a three-month social media campaign, a competition and an entertaining educational video...
January 13, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28080293/proximal-contact-repair-of-complex-amalgam-restorations
#18
M N Zguri, J A Casey, J P Jessup, K S Vandewalle
The carving of a complex amalgam restoration may occasionally result in light proximal contact with the adjacent tooth. The purpose of this study was to investigate the strength of complex amalgam restorations repaired with a proximal slot amalgam preparation. Extracted human third molars of similar coronal size were sectioned 1 mm apical to the height of the contour using a saw and were randomly distributed into 9 groups of 10 teeth each. One pin was placed at each line angle of the flattened dentinal tooth surface...
January 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28077025/total-mercury-levels-in-commercial-fish-species-from-italian-fishery-and-aquaculture
#19
Gabriella Di Lena, Irene Casini, Roberto Caproni, Andrea Fusari, Elena Orban
Total mercury levels were measured in 42 commercial fish species caught off the Central Adriatic and Tyrrhenian coasts of Italy and in 6 aquaculture species. The study on wild fish covered species differing in living habitat and trophic level. The study on farmed fish covered marine and freshwater species from intensive and extensive aquaculture and their feed. Mercury levels were analyzed by Thermal Decomposition-Amalgamation-Atomic Absorption Spectrophotometry. Total mercury concentrations in the muscle of wild fish showed a high variability among species (0...
January 11, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28076252/a-clinical-aid-for-detecting-skin-cancer-the-triage-amalgamated-dermoscopic-algorithm-tada
#20
T Rogers, M L Marino, S W Dusza, S Bajaj, R P Usatine, M A Marchetti, A A Marghoob
PURPOSE: Family physicians (FPs) frequently evaluate skin lesions but may not have the necessary training to accurately and confidently identify lesions that require skin biopsy or specialist referral. We evaluated the diagnostic performance of a new, simplified dermoscopy algorithm for skin cancer detection. METHODS: In this cross-sectional, observation study, attendees of a dermoscopy course evaluated 50 polarized dermoscopy images of skin lesions (27 malignant and 23 benign) using the Triage Amalgamated Dermoscopic Algorithm (TADA)...
November 2016: Journal of the American Board of Family Medicine: JABFM
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