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https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#1
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29147740/geo-spatial-characterization-of-soil-mercury-and-arsenic-at-a-high-altitude-bolivian-gold-mine
#2
Glen D Johnson, Brian Pavilonis, Jack Caravanos, Jean Grassman
Soil mercury concentrations at a typical small-scale mine site in the Bolivian Andes were elevated (28-737 mg/kg or ppm) in localized areas where mercury amalgams were either formed or vaporized to release gold, but was not detectable beyond approximately 10 m from its sources. Arsenic was measurable, exceeding known background levels throughout the mine site (77-137,022 ppm), and was also measurable through the local village of Ingenio (36-1803 ppm). Although arsenic levels were high at all surveyed locations, its spatial pattern followed mercury, being highest where mercury was high...
November 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29146212/the-current-environmental-levels-of-endocrine-disruptors-mercury-cadmium-organochlorine-pesticides-and-pcbs-in-a-belgian-adult-population-and-their-predictors-of-exposure
#3
Catherine Pirard, Stephanie Compere, Katty Firquet, Corinne Charlier
A human biomonitoring study was carried out measuring the levels of endocrine disruptors in 252 participants (18-76 years old) recruited between February and May 2015 from the general population of Liege Province (Belgium). In this study, we reported the recent levels of cadmium and mercury in urine, some organochlorine pesticides and polychlorinated biphenyls (PCBs) in serum, and their relations to demographic characteristics, lifestyle behaviors and dietary habits. The median urinary levels of mercury and cadmium were 0...
October 31, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29143388/in-vitro-assessment-of-retention-and-resistance-failure-loads-of-teeth-restored-with-a-complete-coverage-restoration-and-different-core-materials
#4
Vasileia Tsiagali, Yvoni Kirmanidou, Argirios Pissiotis, Konstantinos Michalakis
PURPOSE: To investigate in vitro the retention and the resistance form, as well as the failure modes of maxillary premolars restored with cast metal crowns and different core materials. MATERIALS AND METHODS: Sixty human extracted maxillary premolars were selected according to their size and were embedded in PMMA resin blocks. After removing a part of their clinical crowns, the teeth were randomly divided into 3 groups of 20 teeth and were either left unrestored, or they were restored with amalgam or composite resin...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29139359/oral-lichen-planus-a-cross-sectional-descriptive-study-of-33-patients
#5
Virendra N Sehgal, Nazim Hussain Syed, Ashok Aggarwal, Shruti Sehgal
Oral lichen planus (OLP), a well-known entity, is often neglected; however, its assessment is considered essential for evolving future strategies for treatment. Thirty-three patients with OLP from 200 consecutive patients with oral mucosal lesions were studied according to demography. Tobacco chewing, smoking, and alcohol intake were recorded. Examination of the oral cavity, using a head light and tongue depressor, was undertaken to define the morphology of the lesion(s). Colored photographs were an essential part of the process...
2017: Skinmed
https://www.readbyqxmd.com/read/29132323/integrative-microrna-and-mrna-deep-sequencing-expression-profiling-in-endemic-burkitt-lymphoma
#6
Cliff I Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A Otieno, John Michael Ong'echa, Ann M Moormann, Jeffrey A Bailey
BACKGROUND: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29126724/dual-or-multi-targeting-inhibitors-the-next-generation-anticancer-agents
#7
REVIEW
Nulgumnalli Manjunathaiah Raghavendra, Divya Pingili, Sundeep Kadasi, Akhila Mettu, S V U M Prasad
Dual-targeting/Multi-targeting of oncoproteins by a single drug molecule represents an efficient, logical and alternative approach to drug combinations. An increasing interest in this approach is indicated by a steady upsurge in the number of articles on targeting dual/multi proteins published in the last 5 years. Combining different inhibitors that destiny specific single target is the standard treatment for cancer. A new generation of dual or multi-targeting drugs is emerging, where a single chemical entity can act on multiple molecular targets...
October 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29120202/collaboration-confidentiality-and-care
#8
Latoya S Moss
There is an increasing call to attend to the needs of students in distress (Reynolds, 2013). Furthermore, research has begun to highlight links between distress, risky, or dangerous behaviors as well as issues in mental health in the higher education population (Deasy, Coughlan, Pironom, Jourdan, & Mannix-McNamara, 2014). The National Alliance on Mental Health and the Jed Foundation (National Alliance on Mental Illness & the Jed Foundation, 2016) estimate that about 20% of enrolled college students will face some type of mental illness...
November 2017: Psychological Services
https://www.readbyqxmd.com/read/29119093/surface-modification-for-bonding-between-amalgam-and-orthodontic-brackets
#9
Wittawat Wongsamut, Sirichom Satrawaha, Kornchanok Wayakanon
OBJECTIVE: Testing of methods to enhance the shear bond strength (SBS) between orthodontic metal brackets and amalgam by sandblasting and different primers. MATERIALS AND METHODS: Three hundred samples of amalgam restorations (KerrAlloy(®)) were prepared in self-cured acrylic blocks, polished, and divided into two groups: nonsandblasted and sandblasted. Each group was divided into five subgroups with different primers used in surface treatment methods, with a control group of bonded brackets on human mandibular incisors...
October 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/29105634/essential-oils-showing-in-vitro-anti-mrsa-and-synergistic-activity-with-penicillin-group-of-antibiotics
#10
Bushra Uzair, Naheed Niaz, Asma Bano, Barkat Ali Khan, Naheed Zafar, Muhammad Iqbal, Riffat Tahira, Fehmida Fasim
This study was planned in order to investigate effective essential oils to inhibit in-vitro growth of Methicillin resistant Staphylococcus aureus (MRSA). In this study using disc diffusion method anti MRSA activity of ten diverse essential oils extracted from traditional plants namely Thymus vulgaris L, Mentha pulegium, Ocimum sanctum, Mentha piperita, Cymbopogon citratus, Rosmarinus officinalis L., Cortex cinnamom, Citrus nobilis x Citrus deliciosa, Origanum vulgare and Mentha sp. was examined. All the essential oils inhibited growth of S...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29105160/strength-in-amalgamation-newer-combination-agents-for-hiv-and-implications-for-practice
#11
Christopher McCoy, Melissa Badowski, Elizabeth Sherman, Rustin Crutchley, Ethan Smith, Daniel B Chastain
Antiretroviral (ART) therapy for treatment of human immunodeficiency virus (HIV) infection has undergone significant changes over the past 30 years. Many single tablet regimens (STR), including newer fixed dose combination (FDC) tablets, are available, offering patients several options for choosing a treatment regimen that works best for them. Given these changes, patients are more likely to adhere to treatment, achieve better clinical outcomes, and experience both fewer side effects and drug-drug interactions...
November 3, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29101638/mercury-concentrations-in-bats-chiroptera-from-a-gold-mining-area-in-the-peruvian-amazon
#12
Mónica Moreno-Brush, Alejandro Portillo, Stefan Dominik Brändel, Ilse Storch, Marco Tschapka, Harald Biester
In the southeastern Peruvian Amazon, artisanal and small-scale gold mining (ASGM) is estimated to have released up to 300 tonnes of mercury (Hg) to the environment between 1995 and 2007 alone, and is claimed to be responsible for Hg concentrations above international thresholds for aquatic wildlife species. Here, we examined whether Hg concentrations in bat populations are potentially related to regional ASGM-Hg releases. We determined Hg concentrations in the fur of bats collected at three different distances from the major ASGM areas in Peru...
November 3, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29100159/niobium-doped-zinc-oxide-nanorods-as-an-electron-transport-layer-for-high-performance-inverted-polymer-solar-cells
#13
Hina Naz, Rai Nauman Ali, Qing Liu, Shangfeng Yang, Bin Xiang
The wet chemical synthesis, characterization and applications of Nb doped ZnO nanorods in bulk heterojunction inverted polymer solar cells are presented in this paper. Zn1-xNbxO with x ranging from 0.01 to 0.07 were successfully synthesized using a novel facile solution-processed wet chemical method. The structural and optical properties of the undoped and Nb doped ZnO nanorods were investigated by transmission electron microscopy, X-ray diffraction, UV-visible near infrared, and photoluminescence (PL) spectroscopies...
October 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29100114/wall-based-measurement-features-provides-an-improved-ivus-coronary-artery-risk-assessment-when-fused-with-plaque-texture-based-features-during-machine-learning-paradigm
#14
Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
BACKGROUND: Planning of percutaneous interventional procedures involves a pre-screening and risk stratification of the coronary artery disease. Current screening tools use stand-alone plaque texture-based features and therefore lack the ability to stratify the risk. METHOD: This IRB approved study presents a novel strategy for coronary artery disease risk stratification using an amalgamation of IVUS plaque texture-based and wall-based measurement features. Due to common genetic plaque makeup, carotid plaque burden was chosen as a gold standard for risk labels during training-phase of machine learning (ML) paradigm...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29075938/feeling-the-insight-uncovering-somatic-markers-of-the-aha-experience
#15
Wangbing Shen, Yu Tong, Yuan Yuan, Huijia Zhan, Chang Liu, Jing Luo, Houde Cai
Whether internal insight can be recognized by experiencing (somatic feeling) remains an unexplored problem. This study investigated the issue by examining potential somatic markers of the "aha" experience occurring at the moment of sudden insight. Participants were required to solve a set of compound remote associates (CRA) problems and were simultaneously monitored via electrodermal and cardiovascular recordings. The "aha"-related psychological components and somatic markers were determined by contrasting insightful solutions with non-insightful solutions...
October 26, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/29074898/an-estimated-carbon-footprint-of-nhs-primary-dental-care-within-england-how-can-dentistry-be-more-environmentally-sustainable
#16
B Duane, M Berners Lee, S White, R Stancliffe, I Steinbach
Introduction National Health Service (NHS) England dental teams need to consider from a professional perspective how they can, along with their NHS colleagues, play their part in reducing their carbon emissions and improve the sustainability of the care they deliver. In order to help understand carbon emissions from dental services, Public Health England (PHE) commissioned a calculation and analysis of the carbon footprint of key dental procedures.Methods Secondary data analysis from Business Services Authority (BSA), Health and Social Care Information Centre (HSCIC) (now called NHS Digital, Information Services Division [ISD]), National Association of Specialist Dental Accountants (NASDA) and recent Scottish papers was undertaken using a process-based and environmental input-output analysis using industry established conversion factors...
October 27, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29073092/unique-amalgamation-of-primary-and-secondary-structural-elements-transform-peptaibols-into-potent-bioactive-cell-penetrating-peptides
#17
Lin Du, April L Risinger, Carter A Mitchell, Jianlan You, Blake W Stamps, Ning Pan, Jarrod B King, Jean C Bopassa, Susan I V Judge, Zhibo Yang, Bradley S Stevenson, Robert H Cichewicz
Mass-spectrometry-based metabolomics and molecular phylogeny data were used to identify a metabolically prolific strain of Tolypocladium that was obtained from a deep-water Great Lakes sediment sample. An investigation of the isolate's secondary metabolome resulted in the purification of a 22-mer peptaibol, gichigamin A (1). This peptidic natural product exhibited an amino acid sequence including several β-alanines that occurred in a repeating ααβ motif, causing the compound to adopt a unique right-handed 311 helical structure...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29064908/the-southampton-consensus-guidelines-for-laparoscopic-liver-surgery-from-indication-to-implementation
#18
Mohammad Abu Hilal, Luca Aldrighetti, Ibrahim Dagher, Bjorn Edwin, Roberto Ivan Troisi, Ruslan Alikhanov, Somaiah Aroori, Giulio Belli, Marc Besselink, Javier Briceno, Brice Gayet, Mathieu D'Hondt, Mickael Lesurtel, Krishna Menon, Peter Lodge, Fernando Rotellar, Julio Santoyo, Olivier Scatton, Olivier Soubrane, Robert Sutcliffe, Ronald Van Dam, Steve White, Mark Christopher Halls, Federica Cipriani, Marcel Van der Poel, Ruben Ciria, Leonid Barkhatov, Yrene Gomez-Luque, Sira Ocana-Garcia, Andrew Cook, Joseph Buell, Pierre-Alain Clavien, Christos Dervenis, Giuseppe Fusai, David Geller, Hauke Lang, John Primrose, Mark Taylor, Thomas Van Gulik, Go Wakabayashi, Horacio Asbun, Daniel Cherqui
OBJECTIVE: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery. BACKGROUND: The exponential growth of laparoscopic liver surgery in recent years mandates the development of clinical practice guidelines to direct the speciality's continued safe progression and dissemination. METHODS: A unique approach to the development of clinical guidelines was adopted...
October 23, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29063633/in-search-of-a-common-currency-a-comparison-of-seven-eq-5d-5l-value-sets
#19
Jan Abel Olsen, Admassu N Lamu, John Cairns
The recently published EQ-5D-5L value sets from Canada, England, Japan, Korea, the Netherlands, Spain, and Uruguay are compared with an aim to identify any similarities in preference pattern. We identify some striking similarities for Canada, England, the Netherlands, and Spain in terms of (a) the relative importance of the 5 dimensions; (b) the relative utility decrements across the 5 levels; and (c) the scale length. On the basis of the observed similarities across these 4 Western countries, we develop an amalgam model, WePP (western preference pattern), and compare it with these 4 value sets...
October 24, 2017: Health Economics
https://www.readbyqxmd.com/read/29057586/mercury-levels-in-hair-samples-of-dentists-a-comparative-study-in-sri-lanka
#20
Lumbini A Wijesekara, Rinzee Usoof, Sachindra S T Gamage, Ruwan Jayasinghe, Nandasena Gamage, Dileep De Silva, Sagarika Ekanayake
AIM: Elemental mercury is widely used in dentistry as dental amalgam. Hair samples constitute preferred biomarkers to determine the index of mercury exposure. In the absence of any published studies, the aim of the present study was to ascertain the level of mercury in a selected sample of dentists and controls in Sri Lanka. METHODS: Hair samples (.7 g) from dentists working in and around the Colombo district in Sri Lanka (n = 50) and controls (n = 50) were digested with sulfuric acid-potassium permanganate solution, and reduced to metallic mercury with stannous chloride...
October 22, 2017: Journal of Investigative and Clinical Dentistry
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