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https://www.readbyqxmd.com/read/28526941/urinary-cadmium-and-cotinine-levels-and-hair-mercury-levels-in-czech-children-and-their-mothers-within-the-framework-of-the-cophes-democophes-projects
#1
Kateřina Forysová, Anna Pinkr-Grafnetterová, Marek Malý, Andrea Krsková, Jaroslav Mráz, Lucie Kašparová, Mája Čejchanová, Lenka Sochorová, Sylva Rödlová, Milena Černá
The COPHES/DEMOCOPHES twin project was performed in 2011-2012 in 17 European countries to harmonize all steps of the human biomonitoring survey. Urinary cadmium, cotinine, phthalate metabolites, and hair mercury were measured in children (N = 120, 6-11 years) and their mothers of reproductive age, living in urban or rural areas. Cadmium in mothers' and children's urine was detected at a geometric mean (GM) concentration 0.227 and 0.109 μg/L, respectively; 95th percentile (P95) was 0.655 and 0.280 μg/L in mothers and children, respectively...
May 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28523494/-a-future-amalgamation-between-the-scientist-and-the-clinician
#2
Sarah Haywood-Small
Personalized medicine is gaining momentum and analytical methods such as MS are ideally situated to provide coherent imaging of human disease. The cancer research field is already starting to benefit from the MS imaging applications; non-cancerous diseases will hopefully enjoy the same success. Often, the way forward is to embrace several techniques, which can complement and verify each other. This approach can be seen as less confrontational as everyone can play a part in the development of a new working practice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28515993/triage-amalgamated-dermoscopic-algorithm-tada-for-skin-cancer-screening
#3
Tova Rogers, Maria Marino, Stephen W Dusza, Shirin Bajaj, Michael A Marchetti, Ashfaq Marghoob
IMPORTANCE: Dermoscopic triage algorithms have been shown to improve beginners' abilities for identifying pigmented skin lesions requiring biopsy. OBJECTIVE: To estimate the diagnostic accuracy of the Triage Amalgamated Dermoscopic Algorithm (TADA) for pigmented and nonpigmented skin cancers. Secondarily, to compare TADAs performance to those of existing triage algorithms for the identification of pigmented skin cancers. DESIGN: Cross-sectional, observational, reader study that took place at a beginner and intermediate level dermoscopy course...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28515298/crimean-congo-hemorrhagic-fever-virus-nucleocapsid-protein-augments-mrna-translation
#4
Subbiah Jeeva, Erdong Cheng, Safder S Ganaie, Mohammad A Mir
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne nairovirus of the Bunyaviridae family, causing severe illness with high mortality rates in humans. Here we demonstrate that CCHFV nucleocapsid protein (CCHFV-NP) augments mRNA translation. CCHFV-NP binds to the viral mRNA 5' UTR with high affinity. It facilitates the translation of reporter mRNA both in vivo and in vitro with the assistance of viral mRNA 5' UTR. CCHFV-NP equally favors the translation of both capped and uncapped mRNAs, demonstrating the independence of this translation strategy on the 5' cap...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28512498/treatment-outcomes-of-full-pulpotomy-as-an-alternative-to-tooth-extraction-in-molars-with-hyperplastic-irreversible-pulpitis-a-case-report
#5
Saeed Asgary, Prashant Verma, Ali Nosrat
Root canal therapy (RCT) is a common and successful treatment for irreversible pulpitis due to carious pulp exposure in mature permanent teeth. However, it is often an expensive procedure, may require multiple appointments, and requires a high level of training and clinical skill, specifically in molars. Uninsured patients, low-income patients, and patients with limited access to specialist care often elect for extraction of restorable teeth with irreversible pulpitis. There is a need for an alternative affordable treatment option to preserve their teeth and maintain chewing function...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28509912/a-resource-on-latitudinal-and-altitudinal-clines-of-ecologically-relevant-phenotypes-of-the-indian-drosophila
#6
Subhash Rajpurohit, Xiaqing Zhao, Paul S Schmidt
The unique geography of the Indian subcontinent has provided diverse natural environments for a variety of organisms. In this region, many ecological indices such as temperature and humidity vary predictably as a function of both latitude and altitude; these environmental parameters significantly affect fundamental dynamics of natural populations. Indian drosophilids are diverse in their geographic distribution and climate tolerance, possibly as a result of climatic adaptation. These associations with environmental parameters are further reflected in a large number of clines that have been reported for various fitness traits along these geographical ranges...
May 16, 2017: Scientific Data
https://www.readbyqxmd.com/read/28509516/variations-in-survival-time-for-amalgam-and-resin-composite-restorations-a-population-based-cohort-analysis
#7
S Birch, R Price, P Andreou, G Jones, A Portolesi
OBJECTIVE: To estimate the association between the restorative material used and time to further treatment across population cohorts with universal coverage for dental treatment. BASIC RESEARCH DESIGN: Cohort study of variation in survival time for tooth restorations over time and by restoration material used based on an Accelerated Failure Time model. CLINICAL SETTING: Primary dental care clinics. PARTICIPANTS: Members of Canada's First Nations and Inuit population covered by the Non-Insured Health Benefits program of Health Canada for the period April 1, 1999 to March 31, 2012...
September 2016: Community Dental Health
https://www.readbyqxmd.com/read/28507826/near-infrared-imaging-for-detecting-caries-and-structural-deformities-in-teeth
#8
Keith Angelino, David A Edlund, Pratik Shah
2-D radiographs, while commonly used for evaluating sub-surface hard structures of teeth, have low sensitivity for early caries lesions, particularly those on tooth occlusal surfaces. Radiographs are also frequently refused by patients over safety concerns. Translucency of teeth in the near-infrared (NIR) range offers a non-ionizing and safe approach to detect dental caries. We report the construction of an NIR (850 nm) LED imaging system, comprised of an NIR source and an intraoral camera for rapid dental evaluations...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28505542/computational-modeling-of-protein-assemblies
#9
REVIEW
Neelesh Soni, M S Madhusudhan
Computational methods to predict the 3D structures of protein interactions fall into 3 categories-template based modeling, protein-protein docking and hybrid/integrative modeling. The two most important considerations for modeling methods are sampling and scoring conformations. Sampling has benefitted from techniques such as fast Fourier transforms (FFT), spherical harmonics and higher order manifolds. Scoring complexes to determine binding free energy is still a challenging problem. Rapid advances have been made in hybrid modeling where experimental data are amalgamated with computations...
May 12, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28504899/metabolic-diversity-and-novelties-in-the-oomycetes
#10
Howard S Judelson
The eukaryotic microbes called oomycetes include many important saprophytes and pathogens, with the latter exhibiting necrotrophy, biotrophy, or obligate biotrophy. Understanding oomycete metabolism is fundamental to understanding these lifestyles. Genome mining and biochemical studies have shown that oomycetes, which belong to the kingdom Stramenopila, secrete suites of carbohydrate- and protein-degrading enzymes adapted to their environmental niches and produce unusual lipids and energy storage compounds...
May 15, 2017: Annual Review of Microbiology
https://www.readbyqxmd.com/read/28501880/-preventive-dentistry-5-secondary-caries
#11
A C C Hollanders, N K Kuper, N J M Opdam, M C D N J M Huysmans
Secondary caries is reported as one of the most important reasons for replacing restorations. The patient's general caries risk plays an important role in the development of secondary caries. The connection, at the patient level, between various factors, the risk of caries and restoration factors, such as the presence of a gap and the kind of restoration material, deserves additional investigation. The minimum gap width in which secondary caries can develop is most likely less than 100 µm and could depend on the patient's caries risk...
May 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28501064/four-or-more-amalgam-fillings-correlate-with-higher-blood-mercury-levels-in-pregnant-women-but-not-high-enough-to-be-of-health-concern
#12
Stefanie L Russell
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Dental associations with blood mercury in pregnant women. Golding J, Steer CD, Gregory S, Lowery T, Hibbeln JR, Taylor CM. Community Dent Oral Epidemiol 2016; 44: 216-22. SOURCE OF FUNDING: This study was funded by a combination of government (UK Medical Research Council), foundation/nonprofit (the Welcome Trust) and university (University of Bristol, UK) grants. TYPE OF STUDY/DESIGN: Cross-sectional...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28490845/a-survey-of-pediatric-dentists-caries-related-treatment-decisions-and-restorative-modalities-a-web-based-survey
#13
Hassan S Halawany, Fouad Salama, Vimal Jacob, Nimmi Biju Abraham, Tarfa Nasser Bin Moharib, Abdulfatah Samih Alazmah, Jawaher Abdulaziz Al Harbi
OBJECTIVE: To identify current practices and the preferred caries-related treatment decisions and restorative modalities of primary teeth among pediatric dental practitioners in Saudi Arabia. MATERIALS AND METHODS: This was a web-based cross-sectional survey conducted among licensed pediatric dental practitioners in Saudi Arabia. Following the retrieval of the email addresses from the Saudi Dental Council, an email explaining the purpose of the study and a link to SurveyMonkey electronic survey consisting of 23 questions was sent to all the members registered under the pediatric dentistry practitioners, starting in September till December 2013...
April 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28490538/cellular-constituents-of-the-prostate-stroma-key-contributors-to-prostate-cancer-progression-and-therapy-resistance
#14
Christine Levesque, Peter S Nelson
Reciprocal signaling between prostate stroma and its epithelium are fundamental to organ development and homeostasis. Similarly, interactions between tumor cells and stromal constituents are central to key aspects of carcinogenesis and malignancy growth involving tumor cell invasion, dissemination, and growth in distant sites. The prostate stroma is complex with several distinct resident cell types, infiltrating nonresident cell types and an amalgam of structural matrix factors, matricellular proteins, metabolites, growth factors, and cytokines...
May 10, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28488068/characterisation-of-secondary-metal-bearing-phases-in-used-dental-amalgam-and-assessment-of-gastric-solubility
#15
Miloš Miler
Detailed SEM/EDS investigation of used dental amalgams was carried out in order to characterise morphology and chemical composition of secondary metal-bearing phases resulting from long-term exposure of dental amalgam to oral environment, and assess their solubility in gastric environment. The investigation revealed numerous secondary phases, represented by compositionally and morphologically complex Hg-, Cu-, Sn-, Ag-, Zn-bearing sulphides and oxides/hydroxides, while sulphates and phosphates are scarce. Secondary metal-bearing phases mostly occur at the amalgam/tooth interface; however, some phases were found only on the occlusal surfaces of amalgam...
May 9, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28482684/21st-century-diseases-commonly-rare-and-rarely-common
#16
Sylvia Daunert, Gurusingham Sitta Sittampalam, Pascal Joseph Goldschmidt-Clermont
Alzheimer's drugs are failing at a rate of 99.6%, and success rate for drugs designed to help patients with this form of dementia is 47 times less than for drugs designed to help patients with cancers (https://www.scientificamerican.com/article/why-alzheimer-s-drugs-keep-failing/ 2014.). How can it be so difficult to produce a valuable drug for Alzheimer's disease? Each human has a unique genetic and epigenetic makeup, thus endowing individuals with a highly unique complement of genes, polymorphisms, mutations, RNAs, proteins, lipids, and complex sugars, resulting in distinct genome, proteome, metabolome, and also microbiome identity...
May 8, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28480953/repair-restorations-questionnaire-survey-among-dentists-in-the-canton-of-zurich-switzerland
#17
Philipp Kanzow, Phoebe Dieckmann, Tim Hausdörfer, Thomas Attin, Annette Wiegand, Florian J Wegehaupt
The aim of this study was to carry out a representative survey on the implementation of and experience with repairs of single-tooth restorations among dentists in the Canton of Zurich, Switzerland. An anonymous questionnaire was sent to all 1,411 dentists registered in the Canton of Zurich; 38.9% of the delivered questionnaires were returned and 35.3% could be evaluated. The statistical analysis comprised Kendall’s rank correlation coefficient (tau), Wilcoxon signed-rank tests, and Kruskal-Wallis tests. The level of significance was set at p≤0...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28478989/effect-of-coping-thickness-and-background-type-on-the-masking-ability-of-a-zirconia-ceramic
#18
Farhad Tabatabaian, Fateme Taghizade, Mahshid Namdari
STATEMENT OF PROBLEM: The masking ability of zirconia ceramics as copings is unclear. PURPOSE: The purpose of this in vitro study was to evaluate the effect of coping thickness and background type on the masking ability of a zirconia ceramic and to determine zirconia coping thickness cut offs for masking the backgrounds investigated. MATERIAL AND METHODS: Thirty zirconia disks in 3 thickness groups of 0.4, 0.6, and 0.8 mm were placed on 9 backgrounds to measure CIELab color attributes using a spectrophotometer...
May 5, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28468161/novel-treatment-planning-of-hemimandibular-hyperplasia-by-the-use-of-three-dimensional-computer-aided-design-and-computer-aided-manufacturing-technologies
#19
Muhanad M Hatamleh, Elizabeth Yeung, Jonas Osher, Chrisopher Huppa
RATIONALE AND AIM: Hemimandibular hyperplasia is characterized by an obvious overgrowth in the size of the mandible on one side, which can extend up to the midline causing facial asymmetry. Surgical resection of the overgrowth depends heavily on the skill and experience of the surgeon. This report describes a novel methodology of applying three-dimensional computer-aided-design and computer-aided-manufacturing principles in improving the outcome of surgery in 2 mandibular hyperplasia patients...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28461261/potential-and-future-scope-of-nanoemulgel-formulation-for-topical-delivery-of-lipophilic-drugs
#20
REVIEW
Pinaki Sengupta, Bappaditya Chatterjee
The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase...
April 28, 2017: International Journal of Pharmaceutics
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