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https://www.readbyqxmd.com/read/29160118/the-effectiveness-of-a-classroom-based-phonological-awareness-program-for-4-5-year-olds
#1
Chrissy Kelly, Suze Leitão, Karen Smith-Lock, Brody Heritage
PURPOSE: Numerous studies have reported a robust relationship between early phonological awareness (PA) and subsequent reading achievement, in addition to the critical role of the alphabetic principle in predicting and supporting later reading and spelling development. Given this association, there has been an increasing push to teach these skills to young children prior to word level reading and spelling instruction. This study evaluated the effectiveness of the Cracking the Code (CtC) program with students aged 3;8-5;4...
November 21, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29159874/meta-synthesis-on-migraine-management
#2
REVIEW
Mia T Minen, Lita Anglin, Alexandra Boubour, Allison Squires, Linda Herrmann
BACKGROUND: Migraine is one of the top 10 most disabling conditions among adults worldwide. Most migraine research is quantitative and indicates concerns about medication adherence, stigma, and more. Qualitative studies might reveal an improved understanding of migraine patients' perspectives regarding migraine treatment. OBJECTIVE: The aim of this study was to synthesize the qualitative research on migraine patients' perspectives regarding migraine treatment to (a) identify common patterns across various types of migraine treatment studies and (b) inform future research...
November 21, 2017: Headache
https://www.readbyqxmd.com/read/29159763/chinese-learners-of-english-see-chinese-words-when-reading-english-words
#3
Fengyang Ma, Haiyang Ai
The present study examines when second language (L2) learners read words in the L2, whether the orthography and/or phonology of the translation words in the first language (L1) is activated and whether the patterns would be modulated by the proficiency in the L2. In two experiments, two groups of Chinese learners of English immersed in the L1 environment, one less proficient and the other more proficient in English, performed a translation recognition task. In this task, participants judged whether pairs of words, with an L2 word preceding an L1 word, were translation words or not...
November 20, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29155867/spectrum-of-pathogen-and-model-specific-histopathologies-in-mouse-models-of-acute-pneumonia
#4
Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions...
2017: PloS One
https://www.readbyqxmd.com/read/29155600/recommended-reading-from-boston-university-school-of-medicine-pulmonary-and-critical-care-medicine-fellows
#5
Eric D Abston, Stephanie M Hon, Andrew Berical, Christine L Reardon
No abstract text is available yet for this article.
November 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29155131/human-lung-epithelial-cell-cultures-for-analysis-of-inhaled-toxicants-lessons-learned-and-future-directions
#6
REVIEW
Pieter S Hiemstra, Gwendolynn Grootaers, Anne M van der Does, Cyrille A M Krul, Ingeborg M Kooter
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However, the validity of the current in vitro models and their acceptance by regulatory authorities as an alternative to animal models is a reason for concern, and requires a critical review...
November 15, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29154033/measuring-preschool-learning-engagement-in-the-laboratory
#7
Simone E Halliday, Susan D Calkins, Esther M Leerkes
Learning engagement is a critical factor for academic achievement and successful school transitioning. However, current methods of assessing learning engagement in young children are limited to teacher report or classroom observation, which may limit the types of research questions one could assess about this construct. The current study investigated the validity of a novel assessment designed to measure behavioral learning engagement among young children in a standardized laboratory setting and examined how learning engagement in the laboratory relates to future classroom adjustment...
November 16, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29151576/mapping-the-sugar-dependency-for-rational-generation-of-a-dna-rna-hybrid-guided-cas9-endonuclease
#8
Fernando Orden Rueda, Michal Bista, Matthew D Newton, Anne U Goeppert, M Emanuela Cuomo, Euan Gordon, Felix Kröner, Jon A Read, Jonathan D Wrigley, David Rueda, Benjamin J M Taylor
The CRISPR-Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is continuously developed to enhance specificity, alter targeting and add new functional moieties. However, one area yet to be explored is the base chemistry of the associated RNA molecules. Here we show the design and optimisation of hybrid DNA-RNA CRISPR and tracr molecules based on structure-guided approaches. Through careful mapping of the ribose requirements of Cas9, we develop hybrid versions possessing minimal RNA residues, which are sufficient to direct specific nuclease activity in vitro and in vivo with reduced off-target activity...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29137575/effect-of-hypocaloric-normoprotein-or-trophic-feeding-versus-target-full-enteral-feeding-on-patient-outcomes-in-critically-ill-adults-a-systematic-review
#9
K A Phan, C M Dux, E J Osland, M C Reade
Uncertainty surrounds the optimal approach to feeding the critically ill, with increasing interest in the concept of intentional underfeeding to reduce metabolic stress while maintaining gut integrity. Conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, this systematic review evaluates clinical outcomes reported in studies comparing hypocaloric normonitrogenous or trophic feeding (collectively 'intentional underfeeding') targeted full energy feeding administered via enteral nutrition to adult critically ill patients...
November 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29133211/beta-lactam-resistance-among-enterobacteriaceae-in-cambodia-the-four-year-itch
#10
REVIEW
Yannick Caron, Rattanak Chheang, Puthea Nop, Soda Meng, Sébastien Boyer, Arnaud Tarantola, Alexandra Kerléguer
Although antibiotics are too often used inappropriately in Cambodia, few data have been published on antimicrobial resistance in this country. Epidemic dissemination and the transfer of resistance genes to other bacterial species put the population at risk. The aim of this study was to evaluate the frequency and characteristics of extended-spectrum beta-lactamase (ESBL) enterobacteriaceae (ESBL-E) isolated in consecutive samples tested at Institut Pasteur du Cambodge (IPC) over a four-year period (2012-2015)...
November 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29125485/cognitive-variability-predicts-incident-alzheimer-s-disease-and-mild-cognitive-impairment-comparable-to-a-cerebrospinal-fluid-biomarker
#11
Carey E Gleason, Derek Norton, Eric D Anderson, Michelle Wahoske, Danielle T Washington, Emre Umucu, Rebecca L Koscik, N Maritza Dowling, Sterling C Johnson, Cynthia M Carlsson, Sanjay Asthana
BACKGROUND: Alzheimer's disease (AD) biomarkers are emerging as critically important for disease detection and monitoring. Most biomarkers are obtained through invasive, resource-intense procedures. A cognitive marker, intra-individual cognitive variability (IICV) may provide an alternative or adjunct marker of disease risk for individuals unable or disinclined to undergo lumbar puncture. OBJECTIVE: To contrast risk of incident AD and mild cognitive impairment (MCI) associated with IICV to risk associated with well-established biomarkers: cerebrospinal fluid (CSF) phosphorylated tau protein (p-tau181) and amyloid-β 42 (Aβ42) peptide...
November 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29119073/assigning-responsibility-to-close-the-loop-on-radiology-test-results
#12
Janice L Kwan, Hardeep Singh
Failure to follow-up on test results represents a serious breakdown point in the diagnostic process which can lead to missed or delayed diagnoses and patient harm. Amidst discussions to ensure fail-safe test result follow-up, an important, yet under-discussed question emerges: how do we determine who is ultimately responsible for initiating follow-up action on the tests that are ordered? This seemingly simple question belies its true complexity. Although many of these complexities are also applicable to other diagnostic specialities, the field of medical imaging provides an ideal context to discuss the challenges of attributing responsibility of test result follow-up...
September 2017: Diagnosis
https://www.readbyqxmd.com/read/29116936/neurophysiological-aspects-of-the-trigeminal-sensory-system-an-update
#13
Frederic Van der Cruyssen, Constantinus Politis
The trigeminal system is one of the most complex cranial nerve systems of the human body. Research on it has vastly grown in recent years and concentrated more and more on molecular mechanisms and pathophysiology, but thorough reviews on this topic are lacking, certainly on the normal physiology of the trigeminal sensory system. Here we review the current literature on neurophysiology of the trigeminal nerve from peripheral receptors up to its central projections toward the somatosensory cortex. We focus on the most recent scientific discoveries and describe historical relevant research to substantiate further...
November 8, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29116199/microscopic-differentiation-of-plasmonic-nanoparticles-for-the-ratiometric-read-out-of-target-dna
#14
Zhenjie Wu, Rui Yang, Di Zu, Shuqing Sun
The development of highly sensitive and rapid methods for detecting DNA is of critical importance. Here, we describe a strategy for the digital detection of target DNA at the femto-molar level. Individual DNA molecules were encoded with a single gold nanorod (AuNR), separated and enriched by magnetic immune-separation. The coding gold nanorods were then de-hybridized and dispersed into a gold nanosphere (AuNS) solution at a certain concentration, and both gold nanoparticles were immobilized on glass slides for dark-field microscopic imaging...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113107/redesigning-journal-clubs-to-staying-current-with-the-literature
#15
Roland N Dickerson, G Christopher Wood, Joseph M Swanson, Rex O Brown
Staying current with the literature is of paramount importance to the pharmacist engaged in an evidence-based clinical practice. Given the expanding roles and responsibilities of today's pharmacists combined with exponential growth in new medical and health sciences literature, staying current has become an extremely daunting task. Traditional journal clubs have focused upon their role as a training vehicle for teaching critical reading skills to residents. However, schools of pharmacy are now required to provide instruction in biostatistics, research design, and interpretation...
November 6, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29111439/the-effect-of-different-brightness-conditions-on-visually-and-memory-guided-saccades
#16
Anna-Maria Felßberg, Isabel Dombrowe
It is commonly assumed that saccades in the dark are slower than saccades in a lit room. Early studies that investigated this issue using electrooculography (EOG) often compared memory guided saccades in darkness to visually guided saccades in an illuminated room. However, later studies showed that memory guided saccades are generally slower than visually guided saccades. Research on this topic is further complicated by the fact that the different existing eyetracking methods do not necessarily lead to consistent measurements...
October 27, 2017: Vision Research
https://www.readbyqxmd.com/read/29110945/the-progression-of-geographic-atrophy-secondary-to-age-related-macular-degeneration
#17
REVIEW
Monika Fleckenstein, Paul Mitchell, K Bailey Freund, SriniVas Sadda, Frank G Holz, Christopher Brittain, Erin C Henry, Daniela Ferrara
Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) that leads to progressive and irreversible loss of visual function. Geographic atrophy is defined by the presence of sharply demarcated atrophic lesions of the outer retina, resulting from loss of photoreceptors, retinal pigment epithelium (RPE), and underlying choriocapillaris. These lesions typically appear first in the perifoveal macula, initially sparing the foveal center, and over time often expand and coalesce to include the fovea...
October 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29109916/self-medication-practices-and-rational-drug-use-habits-among-university-students-a-cross-sectional-study-from-kahramanmara%C3%A5-turkey
#18
Ramazan Azim Okyay, Ayşegül Erdoğan
Background: Self-medication refers to the use of medicines to treat self-diagnosed diseases without consulting any healthcare professionals. Irrational drug use and self-medication have serious negative consequences both on health and economy. Therefore, the aim of this study is to assess the habits related to rational use of drugs (RUD) and to estimate the prevalence of self-medication practices among university students. Methods: This cross-sectional study was conducted on university students in Kahramanmaraş...
2017: PeerJ
https://www.readbyqxmd.com/read/29107248/molecular-cloning-mrna-expression-and-alternative-splicing-of-a-ryanodine-receptor-gene-from-the-citrus-whitefly-dialeurodes-citri-ashmead
#19
Guo-Rui Yuan, Ke-Yi Wang, Xing Mou, Ruo-Yu Luo, Wei Dou, Jin-Jun Wang
Insect ryanodine receptors are the main targets of diamide insecticides that have highly selective insecticidal activity but are less toxic to mammals. Therefore, these insecticides are ideal for pest control. Ryanodine receptors (RyRs) play a critical role in Ca(2+) signaling in muscle and non-muscle cells. In this study, we cloned the complete cDNA (DcRyR) of the RyR from the citrus whitefly, Dialeurodes citri, a serious pest of citrus orchards in China. The open reading frame of RyR is 15,378bp long and encodes a protein with 5126 amino acids with a computed molecular weight of 579...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29104189/theory-practice-and-modernity-leo-strauss-on-rousseau-s-epicureanism
#20
Jared Holley
This article reconstructs Leo Strauss's reading of Rousseau's Epicureanism to argue that his work is unified by an abiding concern with the problem of theory and practice. Strauss sought to clarify the distinction between theory and practice he considered a fundamental precondition of any properly philosophical reflection on political life, and he explained the pernicious obscuring of that distinction through a narrative tracing the modern modifications of classical Epicureanism. Strauss's critical history of modern political thought is thus part of his attempt to restore the classical distinction between theory and practice to the status of a philosophical problem in modernity...
2017: Journal of the History of Ideas
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