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https://www.readbyqxmd.com/read/28333189/fully-automated-disc-diffusion-for-rapid-antibiotic-susceptibility-test-results-a-proof-of-principle-study
#1
Michael Hombach, Marion Jetter, Nicolas Blöchliger, Natalia Kolesnik-Goldmann, Erik C Böttger
Background: Antibiotic resistance poses a significant threat to patients suffering from infectious diseases. Early readings of antibiotic susceptibility test (AST) results could be of critical importance to ensure adequate treatment. Disc diffusion is a well-standardized, established and cost-efficient AST procedure; however, its use in the clinical laboratory is hampered by the many manual steps involved, and an incubation time of 16-18 h, which is required to achieve reliable test results...
February 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28331249/effectiveness-of-mind-mapping-technique-in-information-retrieval-among-medical-college-students-in-puducherry-a-pilot-study
#2
Madhanraj Kalyanasundaram, Sherin Billy Abraham, Divija Ramachandran, Venkatachalam Jayaseelan, Joy Bazroy, Zile Singh, Anil Jacob Purty
BACKGROUND: The traditional teaching learning methods involve a one way process of transmission of knowledge leaving the students lacking behind in creative abilities. Medical schools need to change their teaching strategies to keep the interest of students and empower them for future self- learning and critical thinking. OBJECTIVE: To assess the impact of mind mapping technique in information retrieval among medical college students in Puducherry. METHODS: A pilot study was conducted using experimental study design among sixth semester MBBS students (n = 64) at a medical college in Puducherry, India...
January 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28329450/public-views-on-pulse-oximetry-screening-for-critical-congenital-heart-disease
#3
Praveen Kumar, Hari Iyengar, Prerna Kumar
OBJECTIVES: To understand public views on pulse oximetry screening for critical congenital heart disease. METHODS: Two hundred thirteen adults read a brief vignette describing the importance of early detection of critical congenital heart disease and then answered five questions on a five-point scale of how likely or unlikely they were to support pulse oximetry screening. Responses were tabulated and analyzed using a Fisher exact test, and logistic regression was used to estimate odds ratios for adjusted associations using generalized estimating equations...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28327193/longitudinal-evaluation-of-aortic-hemodynamics-in-marfan-syndrome-new-insights-from-a-4d-flow-cardiovascular-magnetic-resonance-multi-year-follow-up-study
#4
Julia Geiger, Daniel Hirtler, Kristina Gottfried, Ozair Rahman, Emilie Bollache, Alex J Barker, Michael Markl, Brigitte Stiller
BACKGROUND: The aim of this 4D flow cardiovascular magnetic resonance (CMR) follow-up study was to investigate longitudinal changes in aortic hemodynamics in adolescent patients with Marfan syndrome (MFS). METHODS: 4D flow CMR for the assessment of in-vivo 3D blood flow with full coverage of the thoracic aorta was performed twice (baseline scan t1/follow-up scan t2) in 19 adolescent MFS patients (age at t1: 12.7 ± 3.6 years, t2: 16.2 ± 4.3 years) with a mean follow-up duration of 3...
March 22, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28325206/improving-glycemic-control-safely-in-non-critical-care-patients-a-collaborative-systems-approach-in-nine-hospitals
#5
Gregory A Maynard, Diana Childers, Janet Holdych, Heather Kendall, Tom Hoag, Karen Harrison
BACKGROUND: Practice variations in insulin management and glycemic adverse events led nine Dignity Health hospitals to initiate a collaborative effort to improve hypoglycemia, uncontrolled hyperglycemia, and glycemic control. METHODS: Non-critical care adult inpatients with ≥4 point-of-care blood glucose (BG) readings in a ≥2-day period were included. Balanced glucometric goals for each hospital were individualized to improve performance by 10%-20% from baseline or achieve top performance derived from Society of Hospital Medicine (SHM) benchmarking studies...
April 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28322871/recurrent-emergence-of-structural-variants-of-ltr-retrotransposon-csrn1-evolving-novel-expression-strategy-and-their-selective-expansion-in-a-carcinogenic-liver-fluke-clonorchis-sinensis
#6
Seon-Hee Kim, Yoon Kong, Young-An Bae
Autonomous retrotransposons, in which replication and transcription are coupled, encode the essential gag and pol genes as a fusion or separate overlapping form(s) that are expressed in single transcripts regulated by a common upstream promoter. The element-specific expression strategies have driven development of relevant translational recoding mechanisms including ribosomal frameshifting to satisfy the protein stoichiometry critical for the assembly of infectious virus-like particles. Retrotransposons with different recoding strategies exhibit a mosaic distribution pattern across the diverse families of reverse transcribing elements, even though their respective distributions are substantially skewed towards certain family groups...
March 16, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28320310/treetoreads-a-pipeline-for-simulating-raw-reads-from-phylogenies
#7
Emily Jane McTavish, James Pettengill, Steven Davis, Hugh Rand, Errol Strain, Marc Allard, Ruth E Timme
BACKGROUND: Using phylogenomic analysis tools for tracking pathogens has become standard practice in academia, public health agencies, and large industries. Using the same raw read genomic data as input, there are several different approaches being used to infer phylogenetic tree. These include many different SNP pipelines, wgMLST approaches, k-mer algorithms, whole genome alignment and others; each of these has advantages and disadvantages, some have been extensively validated, some are faster, some have higher resolution...
March 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28318503/sociotechnical-systems-as-a-framework-for-regulatory-system-design-and-evaluation-using-work-domain-analysis-to-examine-a-new-regulatory-system
#8
Tony Carden, Natassia Goode, Gemma J M Read, Paul M Salmon
Like most work systems, the domain of adventure activities has seen a series of serious incidents and subsequent calls to improve regulation. Safety regulation systems aim to promote safety and reduce accidents. However, there is scant evidence they have led to improved safety outcomes. In fact there is some evidence that the poor integration of regulatory system components has led to adverse safety outcomes in some contexts. Despite this, there is an absence of methods for evaluating regulatory and compliance systems...
March 15, 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28318285/reading-through-the-life-span-individual-differences-in-psycholinguistic-effects
#9
Rob A I Davies, Ruth Arnell, Julia M H Birchenough, Debbie Grimmond, Sam Houlson
The effects of psycholinguistic variables are critical to the evaluation of theories about the cognitive reading system. However, reading research has tended to focus on the impact of key variables on average performance. We report the first investigation examining variation in psycholinguistic effects across the life span, from childhood into old age. We analyzed the performance of a sample of 535 readers, aged 8-83 years in lexical decision and pronunciation tasks. Our findings show that the effects on reading of two key variables, frequency and AoA, decrease in size with increasing age over the life span...
March 20, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28306625/visualization-of-the-retina-and-vitreous-during-vitreoretinal-surgery-new-technologies
#10
Sarah P Read, Jorge A Fortun
PURPOSE OF REVIEW: Visualization remains a critical factor in successful ocular surgery.Here we review new technology that has the potential to allow for safer and more efficient retinal surgery. RECENT FINDINGS: Vitreoretinal surgery poses unique visualization challenges such as the need for specialized optical systems and the delicate and microscopic features of retinal structures. Better retinal visualization allows for new approaches to increasingly complex retinal cases...
March 16, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28306322/recommended-reading-from-rutgers-robert-wood-johnson-medical-school-pulmonary-and-critical-care-medicine-fellows
#11
Sabiha Hussain, Sugeet Jagpal, Saqib H Baig, Edward K Len, Pallak Agarwal
No abstract text is available yet for this article.
March 17, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28303756/the-cognitive-underpinnings-of-mental-model-construction-in-l1-and-l2
#12
Polly O'Rourke, Michael F Bunting
The current study investigated the ability to create mental models and the role of working memory in mental model ability in the first and second language with English-Spanish bilinguals using L1 and L2 versions of the Spatial Integration Task. Participants showed effects of continuity in accuracy in L1 and L2 but only in L1 did they show effects in the reading times. In L1, working memory capacity predicted identification accuracy for discontinuous descriptions in L1 as well as reading time for the critical discontinuous sentence...
March 17, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28300641/genome-editing-using-crispr-cas9-based-knock-in-approaches-in-zebrafish
#13
REVIEW
Shahad Albadri, Filippo Del Bene, Céline Revenu
With its variety of applications, the CRISPR/Cas9 genome editing technology has been rapidly evolving in the last few years. In the zebrafish community, knock-out reports are constantly increasing but insertion studies have been so far more challenging. With this review, we aim at giving an overview of the homologous directed repair (HDR)-based knock-in generation in zebrafish. We address the critical points and limitations of the procedure such as cutting efficiency of the chosen single guide RNA, use of cas9 mRNA or Cas9 protein, homology arm size etc...
March 11, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28298214/climat-het-detecting-subclonal-copy-number-alterations-and-loss-of-heterozygosity-in-heterogeneous-tumor-samples-from-whole-genome-sequencing-data
#14
Zhenhua Yu, Ao Li, Minghui Wang
BACKGROUND: Copy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These aberrations are continuously accumulated during the procedure of clonal evolution and patterned by phylogenetic branching. This invariably results in the emergence of multiple cell populations with distinct complement of mutational landscapes in tumor sample. With the advent of next-generation sequencing technology, inference of subclonal populations has become one of the focused interests in cancer-associated studies, and is usually based on the assessment of combinations of somatic single-nucleotide variations (SNV), CNA and LOH...
March 15, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28297080/duration-of-platelet-storage-and-outcomes-of-critically-ill-patients
#15
Andrew Flint, Cécile Aubron, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen C Cheng, Colin Hegarty, Michael C Reade, Zoe McQuilten
BACKGROUND: The storage duration of platelet (PLT) units is limited to 5 to 7 days. This study investigates whether PLT storage duration is associated with patient outcomes in critically ill patients. STUDY DESIGN AND METHODS: This study was a retrospective analysis of critically ill patients admitted to the intensive care unit (ICU) of two hospitals in Australia who received one or more PLT transfusions from 2008 to 2014. Storage duration was approached in several different ways...
March 2017: Transfusion
https://www.readbyqxmd.com/read/28295894/cost-effectiveness-analysis-appraisal-and-application-an-emergency-medicine-perspective
#16
Michael D April, Brian P Murray
Cost-effectiveness is an important goal for emergency care delivery. The many diagnostic, treatment, and disposition decisions made in the emergency department (ED) have a significant impact upon healthcare resource utilization. Cost-effectiveness analysis (CEA) is an analytic tool to optimize these resource allocation decisions through the systematic comparison of costs and effects of alternative healthcare decisions. Yet few emergency medicine leaders and policy-makers have any formal training in CEA methodology...
March 10, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28288286/recommended-reading-from-the-newyork-presbyterian-hospital-weill-cornell-medicine-pulmonary-and-critical-care-medicine-fellows
#17
Kevin C Ma, Daniel S Jones, David R Price, Meredith L Turetz
No abstract text is available yet for this article.
March 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28285044/mirrors-are-hard-to-break-a-critical-review-and-behavioral-evidence-on-mirror-image-processing-in-developmental-dyslexia
#18
Tânia Fernandes, Isabel Leite
The relation between reversal errors (e.g., d for b, Я for R) and developmental dyslexia has been elusive. In this study, we investigated the roles of reading level, visual category, and orientation processing in this relation. Children with developmental dyslexia, chronological-age-matched controls, and reading-level-matched controls performed two "same-different" matching tasks on reversible (e.g., b) and nonreversible (e.g., e) letters and on geometric shapes (e.g., ). In the orientation-based task, orientation processing was explicitly required; in the shape-based task, orientation processing would be automatic inasmuch as it was task irrelevant and would hinder successful performance...
March 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28277688/-his-skin-doesn-t-match-what-he-wants-to-do-children-s-perceptions-of-stereotype-threat
#19
Kate M Wegmann
Stereotype threat is a key contributor to chronic racial/ethnic disparities in mental health, physical health, and academic outcomes. Emerging evidence suggests that stereotype threat may be a critical concern for narrowing these disparities. The objective of the current study is to determine whether children between the ages of 7-11 consciously perceive stereotype threat, and to examine children's descriptions of the phenomenon. Age-appropriate vignettes illustrated 6 forms of stereotype threat. 15 children from diverse racial/ethnic backgrounds read and responded to 3 vignettes each...
March 9, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28275767/dissolution-test-for-risk-assessment-of-nanoparticles-a-pilot-study
#20
Pasquale Bove, Maria Ada Malvindi, Sachin Sayaji Kote, Rosalia Bertorelli, Maria Summa, Stefania Sabella
Worldwide efforts are currently trying to produce effective risk assessment models for orally ingested nanoparticles. These tests should provide quantitative information on the bioaccessibility and bioavailability of products of biotransformation, such as dissolved ionic species and/or aggregates. In vitro dissolution tests might be useful for nanoparticle risk assessment, because of their potential to quantitatively monitor the changes of specific properties (e.g., dissolution, agglomeration, etc.), which are critical factors linked to bioaccessibility/bioavailability...
March 9, 2017: Nanoscale
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