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https://www.readbyqxmd.com/read/29338812/comprehensive-assessment-of-the-quality-of-salmonella-whole-genome-sequence-data-available-in-public-sequence-databases-using-the-salmonella-in-silico-typing-resource-sistr
#1
James Robertson, Catherine Yoshida, Peter Kruczkiewicz, Celine Nadon, Anil Nichani, Eduardo N Taboada, John Howard Eagles Nash
Public health and food safety institutions around the world are adopting whole genome sequencing (WGS) to replace conventional methods for characterizing Salmonella for use in surveillance and outbreak response. Falling costs and increased throughput of WGS have resulted in an explosion of data, but questions remain as to the reliability and robustness of the data. Due to the critical importance of serovar information to public health, it is essential to have reliable serovar assignments available for all of the Salmonella records...
January 17, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29335140/-the-sexualisation-of-the-care-relationship-by-the-patient-in-gerontology
#2
REVIEW
Flavie Gouraud, Franck Rexand-Galais, Benoit Maillard, Hélène Delrieu
The expression of the sexuality of the ageing patient in the care setting, particularly when it concerns the genital area and involves the caregiver without he or she being aware, constitutes a critical situation for the geriatric teams. A psychodynamic reading of these situations is important for the caregiving teams in order to optimise the somatic treatment and to prevent the risk of an unsuitable reactive treatment. This article presents a clinical case as an example.
January 2018: Soins. Gérontologie
https://www.readbyqxmd.com/read/29330168/mrb7260-is-essential-for-productive-protein-rna-interactions-within-the-rna-editing-substrate-binding-complex-during-trypanosome-rna-editing
#3
Natalie M McAdams, Rachel M Simpson, Runpu Chen, Yijun Sun, Laurie Read
The trypanosome RNA Editing Substrate Binding Complex (RESC) acts as the platform for mitochondrial uridine insertion/deletion RNA editing and facilitates the protein-protein and protein-RNA interactions required for the editing process. RESC is broadly comprised of two subcomplexes: GRBC (Guide RNA Binding Complex) and REMC (RNA Editing Mediator Complex). Here, we characterize the function and position in RESC organization of a previously unstudied RESC protein, MRB7260. We show that MRB7260 forms numerous RESC-related complexes, including a novel, small complex with the guide RNA binding protein, GAP1, which is a canonical GRBC component, and REMC components MRB8170 and TbRGG2...
January 12, 2018: RNA
https://www.readbyqxmd.com/read/29325522/correction-to-relatively-frequent-switching-of-transcription-start-sites-during-cerebellar-development
#4
Peter Zhang, Emmanuel Dimont, Thomas Ha, Douglas J Swanson, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Carsten O Daub, Erik Arner, Piero Carninci, Yoshihide Hayashizaki, Alistair R R Forrest, Winston Hide, Dan Goldowitz
The authors of the original article [1] would like to recognize the critical contribution of core members of the FANTOM5 Consortium, who played the critical role of HeliScopeCAGE sequencing experiments, quality control of tag reads and processing of the raw sequencing data.
January 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29324967/theoretical-saturation-in-qualitative-research-an-experience-report-in-interview-with-schoolchildren
#5
Luciana de Cassia Nunes Nascimento, Tania Vignuda de Souza, Isabel Cristina Dos Santos Oliveira, Juliana Rezende Montenegro Medeiros de Moraes, Rosane Cordeiro Burla de Aguiar, Liliane Faria da Silva
OBJECTIVE: report the experience of applying the theoretical data saturation technique in qualitative research with schoolchildren. METHOD: critical reading of primary sources and compilation of raw data, followed by thematic grouping through colorimetric codification and allocation of themes/types of statements in charts to find theoretical saturation for each grouping. RESULTS: colorimetric codification occurred according to previously established themes: bodily hydration; physical activities and play; handling of sickle-cell disease; feeding and clothing...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29323179/neither-action-nor-phonological-video-games-make-dyslexic-children-read-better
#6
Magdalena Łuniewska, Katarzyna Chyl, Agnieszka Dębska, Agnieszka Kacprzak, Joanna Plewko, Marcin Szczerbiński, Jakub Szewczyk, Anna Grabowska, Katarzyna Jednoróg
The prevalence and long-term consequences of dyslexia make it crucial to look for effective and efficient ways of its therapy. Action video games (AVG) were implied as a possible remedy for difficulties in reading in Italian and English-speaking children. However, the studies examining the effectiveness of AVG application in dyslexia suffered from significant methodological weaknesses such as small sample sizes and lack of a control group with no intervention. In our study, we tested how two forms of training: based on AVG and on phonological non-action video games (PNAVG), affect reading in a group of fifty-four Polish children with dyslexia...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322917/identification-of-natural-antimicrobial-peptides-from-bacteria-through-metagenomic-and-metatranscriptomic-analysis-of-high-throughput-transcriptome-data-of-taiwanese-oolong-teas
#7
Kai-Yao Huang, Tzu-Hao Chang, Jhih-Hua Jhong, Yu-Hsiang Chi, Wen-Chi Li, Chien-Lung Chan, K Robert Lai, Tzong-Yi Lee
BACKGROUND: Anti-microbial peptides (AMPs), naturally encoded by genes and generally containing 12-100 amino acids, are crucial components of the innate immune system and can protect the host from various pathogenic bacteria and viruses. In recent years, the widespread use of antibiotics has resulted in the rapid growth of antibiotic-resistant microorganisms that often induce critical infection and pathogenesis. Recently, the advent of high-throughput technologies has led molecular biology into a data surge in both the amount and scope of data...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29320806/experiences-of-living-kidney-donors-during-the-donation-process
#8
Hanne Agerskov, Claus Bistrup, Mette S Ludvigsen, Birthe D Pedersen
BACKGROUND: The shortage of organs from deceased donors has led to more living donation. Furthermore, immunological developments have made it possible to perform kidney transplantation despite preformed antibodies against the donor organ. This has led to a broader recruitment base of living donors. OBJECTIVE: The objective was to investigate experiences and considerations on becoming, and during the process of being, a living kidney donor. MATERIALS AND METHODS: Interviews and participant observation were conducted before, during and after the donation...
January 10, 2018: Journal of Renal Care
https://www.readbyqxmd.com/read/29320216/legibility-of-text-and-pictograms-in-variable-message-signs-can-single-word-messages-outperform-pictograms
#9
Javier Roca, Beatriz Insa, Pilar Tejero
OBJECTIVE: The current research shows the advantage of single-word messages in the particular case of variable message signs (VMSs) with a high aspect ratio. BACKGROUND: Early studies on traffic sign design proposed that pictorial information would advantage equivalent text messages in static signs. METHOD: We used a driving simulator to present individually 36 VMSs, showing six words (e.g., "congestion") and six danger signs (e.g., congestion traffic sign)...
January 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29316820/cost-effectiveness-of-access-to-critical-cerebral-emergency-support-services-access-a-neuro-emergent-telemedicine-consultation-program
#10
Justin Whetten, David N van der Goes, Huy Tran, Mark Moffett, Colin Semper, Howard Yonas
AIMS: Access to Critical Cerebral Emergency Support Services (ACCESS) was developed as a low-cost solution to providing neuro-emergent consultations to rural hospitals in New Mexico that do not offer comprehensive stroke care. ACCESS is a two-way audio visual program linking remote emergency department physicians and their patients to stroke specialists. ACCESS also has an education component in which hospitals receive training from stroke specialists on the triage and treatment of patients...
January 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29312831/translating-genomics-into-practice-for-real-time-surveillance-and-response-to-carbapenemase-producing-enterobacteriaceae-evidence-from-a-complex-multi-institutional-kpc-outbreak
#11
Jason C Kwong, Courtney R Lane, Finn Romanes, Anders Gonçalves da Silva, Marion Easton, Katie Cronin, Mary Jo Waters, Takehiro Tomita, Kerrie Stevens, Mark B Schultz, Sarah L Baines, Norelle L Sherry, Glen P Carter, Andre Mu, Michelle Sait, Susan A Ballard, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Background: Until recently, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae were rarely identified in Australia. Following an increase in the number of incident cases across the state of Victoria, we undertook a real-time combined genomic and epidemiological investigation. The scope of this study included identifying risk factors and routes of transmission, and investigating the utility of genomics to enhance traditional field epidemiology for informing management of established widespread outbreaks...
2018: PeerJ
https://www.readbyqxmd.com/read/29310587/unique-dual-indexed-sequencing-adapters-with-umis-effectively-eliminate-index-cross-talk-and-significantly-improve-sensitivity-of-massively-parallel-sequencing
#12
Laura E MacConaill, Robert T Burns, Anwesha Nag, Haley A Coleman, Michael K Slevin, Kristina Giorda, Madelyn Light, Kevin Lai, Mirna Jarosz, Matthew S McNeill, Matthew D Ducar, Matthew Meyerson, Aaron R Thorner
BACKGROUND: Sample index cross-talk can result in false positive calls when massively parallel sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant discovery, ancient DNA investigations, microbial detection in human samples, or circulating cell-free tumor DNA (ctDNA) variant detection. Therefore, the limit-of-detection of an MPS assay is directly related to the degree of index cross-talk. RESULTS: Cross-talk rates up to 0.29% were observed when using standard, combinatorial adapters, resulting in 110,180 (0...
January 8, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29310460/stone-compositions-and-different-lithotripters-in-pcnl
#13
Mohammad Hadi Radfar, Behnam Shakiba
We read with great interest the paper by York and colleagues [1] entitled "Randomized controlled trial comparing three different modalities of lithotrites for intracorporeal lithotripsy in PCNL". This study showed that the safety and efficacy of Cyberwand, Lithoclast Select, and the StoneBreaker lithotripters are similar and comparable. They stated that "the clearance rate of "hard" stones (defined as brushite, cystine, and uric acid stones) was comparable across the 3 groups). We would like to point out that this statement is one side of the coin...
January 8, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29306593/the-benefit-of-a-triage-system-to-expedite-acute-stroke-head-computed-tomography-interpretations
#14
Thomas F Osborne, Andrew J Grabiel, Reese H Clark
BACKGROUND AND PURPOSE: We developed and tested a triage system to accelerate the interpretation of stroke head computed tomographies (CTs), with the goal of optimizing the time available for acute stroke therapy. MATERIALS AND METHODS: In our practice, acute stroke protocol head CTs have been given the highest reading priority. We implemented a technologically enabled prioritization infrastructure to consistently present these critical cases to our radiologists so they are evaluated before other examinations...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29305389/before-narrative-episodic-reading-and-representations-of-chronic-pain
#15
Sara Wasson
This article suggests that some illness experience may require a reading practice less concerned with narrative coherence or self-authorship, and more interested in the value of textual fragments, episodes and moments considered outside a narrative framework. Chronic pain can pose multiple challenges to the narrative orientations celebrated in both 'survivorship' discourse and classic medical humanities scholarship. In its recalcitrance to cure, its often mysterious aetiology and its complex blend of somatic, interpersonal and affective elements, representations of chronic pain can require a richer vocabulary of temporality...
January 5, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29304740/the-complete-and-fully-assembled-genome-sequence-of-aeromonas-salmonicida-subsp-pectinolytica-and-its-comparative-analysis-with-other-aeromonas-species-investigation-of-the-mobilome-in-environmental-and-pathogenic-strains
#16
Friedhelm Pfeiffer, Maria-Antonia Zamora-Lagos, Martin Blettinger, Assa Yeroslaviz, Andreas Dahl, Stephan Gruber, Bianca H Habermann
BACKGROUND: Due to the predominant usage of short-read sequencing to date, most bacterial genome sequences reported in the last years remain at the draft level. This precludes certain types of analyses, such as the in-depth analysis of genome plasticity. RESULTS: Here we report the finalized genome sequence of the environmental strain Aeromonas salmonicida subsp. pectinolytica 34mel, for which only a draft genome with 253 contigs is currently available. Successful completion of the transposon-rich genome critically depended on the PacBio long read sequencing technology...
January 5, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29303790/relaxation-before-debriefing-during-high-fidelity-simulation-improves-memory-retention-of-residents-at-three-months-a-prospective-randomized-controlled-study
#17
Marc Lilot, Jean-Noel Evain, Christian Bauer, Jean-Christophe Cejka, Alexandre Faure, Baptiste Balança, Olivia Vassal, Cécile Payet, Bernard Bui Xuan, Antoine Duclos, Jean-Jacques Lehot, Thomas Rimmelé
BACKGROUND: High-fidelity simulation is known to improve participant learning and behavioral performance. Simulation scenarios generate stress that affects memory retention and may impact future performance. The authors hypothesized that more participants would recall three or more critical key messages at three months when a relaxation break was performed before debriefing of critical event scenarios. METHODS: Each resident actively participated in one scenario and observed another...
January 5, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29303208/journal-club-sessions-in-the-intensive-care-unit-a-conceptual-framework
#18
Bjoern Zante, Patricia Stoecklin, Joerg Christian Schefold
Journal Club sessions are regarded highly effective tools for continued medical education. They aim to keep participants up to date with the current available literature and may enhance one's critical reading, interpretation, and discussion skills. Thus, Journal Clubs should be implemented as part of educational curricula in intensive care medicine. Here, we provide a conceptual framework that may support medical educators and programme directors to successfully implement structured Journal Club sessions. Moreover, we discuss the technical aspects and future perspectives of respective educational formats...
January 5, 2018: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29300448/simple-and-sensitive-quantification-of-micrornas-via-ps-au-microspheres-based-dna-probe-and-dsn-assist-signal-amplification-platform
#19
Qian Zhao, Jiafang Piao, Weipan Peng, Yang Wang, Bo Zhang, Xiaoqun Gong, Jin Chang
Identifying the microRNA (miRNA) expression level can provide critical information for early diagnosis of cancers or monitoring the cancer therapeutic efficacy. This paper focused on a kind of gold nanoparticles coated polystyrene microbeads (PS@Au microspheres)-based DNA probe as miRNA capture and duplex specific nuclease (DSN) signal amplification platform based on RGB value read-out for miRNAs detection. In virtue of the outstanding selectivity and simple experimental operation, 5'- fluorochrome -labeled molecular beacons (MBs) were immobilized on PS@Au microspheres via their 3'-thiol, in the wake of the fluorescence quenching by nanoparticle surface energy transfer (NSET)...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29297275/identification-and-characterization-of-conserved-lncrnas-in-human-and-rat-brain
#20
Dan Li, Mary Qu Yang
BACKGROUND: Long noncoding RNAs (lncRNAs) are involved in diverse biological processes and play an essential role in various human diseases. The number of lncRNAs identified has increased rapidly in recent years owing to RNA sequencing (RNA-Seq) technology. However, presently, most lncRNAs are not well characterized, and their regulatory mechanisms remain elusive. Many lncRNAs show poor evolutionary conservation. Thus, the lncRNAs that are conserved across species can provide insight into their critical functional roles...
December 28, 2017: BMC Bioinformatics
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