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https://www.readbyqxmd.com/read/28106817/value-based-caching-in-information-centric-wireless-body-area-networks
#1
Fadi M Al-Turjman, Muhammad Imran, Athanasios V Vasilakos
We propose a resilient cache replacement approach based on a Value of sensed Information (VoI) policy. To resolve and fetch content when the origin is not available due to isolated in-network nodes (fragmentation) and harsh operational conditions, we exploit a content caching approach. Our approach depends on four functional parameters in sensory Wireless Body Area Networks (WBANs). These four parameters are: age of data based on periodic request, popularity of on-demand requests, communication interference cost, and the duration for which the sensor node is required to operate in active mode to capture the sensed readings...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28103762/cultural-and-biological-factors-modulate-spatial-biases-over-development
#2
Luisa Girelli, Chiara Valeria Marinelli, Giuseppe Grossi, Lisa S Arduino
Increasing evidence supports the contribution of both biological and cultural factors to visuospatial processing. The present study adds to the literature by exploring the interplay of perceptual and linguistic mechanisms in determining visuospatial asymmetries in adults (Experiment 1) and children (Experiment 2). In particular, pre-schoolers (3 and 5 year-olds), school-aged children (8 year-old), and adult participants were required to bisect different types of stimuli, that is, lines, words, and figure strings...
January 19, 2017: Laterality
https://www.readbyqxmd.com/read/28101271/the-impact-of-an-interactive-statistics-module-on-novices-development-of-scientific-process-skills-and-attitudes-in-a-first-semester-research-foundations-course
#3
Lynnsay A Marsan, Christina E D'Arcy, Jeffrey T Olimpo
Evidence suggests that incorporating quantitative reasoning exercises into existent curricular frameworks within the science, technology, engineering, and mathematics (STEM) disciplines is essential for novices' development of conceptual understanding and process skills in these domains. Despite this being the case, such studies acknowledge that students often experience difficulty in applying mathematics in the context of scientific problems. To address this concern, the present study sought to explore the impact of active demonstrations and critical reading exercises on novices' comprehension of basic statistical concepts, including hypothesis testing, experimental design, and interpretation of research findings...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28099651/contribution-of-oswaldo-paulo-forattini-to-public-health-analysis-of-scientific-production
#4
Juliana Gonçalves Reis, Keilla Miki Kobayashi, Helene Mariko Ueno, Cristiane Martins Ribeiro, Telma Abdalla de Oliveira Cardoso
OBJECTIVE: To analyze the main characteristics of the scientific production of Oswaldo Paulo Forattini, researcher and, for 40 years, editor of Revista de Saúde Pública. METHODS: Descriptive study with bibliometric approach conducted in three steps. (1) identification of bibliographic records using the following search strategy: "Oswaldo Paulo Forattini" OR "Forattini OP" OR "Forattini" up information sources Google Scholar, Web of Science, and PubMed, in July 2016, which retrieved 867 records...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28098800/characterization-of-the-transcriptome-and-gene-expression-of-brain-tissue-in-sevenband-grouper-hyporthodus-septemfasciatus-in-response-to-nnv-infection
#5
Jong-Oh Kim, Jae-Ok Kim, Wi-Sik Kim, Myung-Joo Oh
Grouper is one of the favorite sea food resources in Southeast Asia. However, the outbreaks of the viral nervous necrosis (VNN) disease due to nervous necrosis virus (NNV) infection have caused mass mortality of grouper larvae. Many aqua-farms have suffered substantial financial loss due to the occurrence of VNN. To better understand the infection mechanism of NNV, we performed the transcriptome analysis of sevenband grouper brain tissue, the main target of NNV infection. After artificial NNV challenge, transcriptome of brain tissues of sevenband grouper was subjected to next generation sequencing (NGS) using an Illumina Hi-seq 2500 system...
January 13, 2017: Genes
https://www.readbyqxmd.com/read/28097842/in-hospital-capacity-building-in-research-and-management-for-pediatric-professionals
#6
Graciela Demirdjian, Susana Rodríguez, Juan C Vassallo, Vilma Irazola, Josefa Rodríguez
We describe an educational strategy aimed at capacity-building of hospital health care professionals in research and management initiated at a pediatric hospital in 2006, and the results obtained eight years after its implementation. Research and Management in Pediatrics (GIP) is an annual 250-hour course combining meetings and off-site assignments delivered through the Hospital's on-line campus. It provides students with practical tools for research (epidemiology, methodology, bibliographic search, evidencebased medicine, biostatistics) and management (strategic planning, management programs, health services research, quality improvement, health economics)...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28096517/the-nucleoside-analog-clitocine-is-a-potent-and-efficacious-readthrough-agent
#7
Westley J Friesen, Christopher R Trotta, Yuki Tomizawa, Jin Zhuo, Briana Johnson, Jairo Sierra, Bijoyita Roy, Marla Weetall, Jean Hedrick, Josephine Sheedy, James Takasugi, Young-Choon Moon, Suresh Babu, Ramil Baiazitov, John D Leszyk, Thomas W Davis, Stuart W Peltz, Ellen M Welch
Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a large number of the most common forms of cancers and are known to cause or contribute to the progression of disease. Low molecular weight compounds that induce readthrough of nonsense mutations offer a new means of treating patients with genetic disorders or cancers resulting from nonsense mutations. We have identified the nucleoside analog clitocine as a potent and efficacious suppressor of nonsense mutations...
January 17, 2017: RNA
https://www.readbyqxmd.com/read/28093787/in-situ-data-analytics-and-indexing-of-protein-trajectories
#8
Travis Johnston, Boyu Zhang, Adam Liwo, Silvia Crivelli, Michela Taufer
The transition toward exascale computing will be accompanied by a performance dichotomy. Computational peak performance will rapidly increase; I/O performance will either grow slowly or be completely stagnant. Essentially, the rate at which data are generated will grow much faster than the rate at which data can be read from and written to the disk. MD simulations will soon face the I/O problem of efficiently writing to and reading from disk on the next generation of supercomputers. This article targets MD simulations at the exascale and proposes a novel technique for in situ data analysis and indexing of MD trajectories...
January 17, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28092317/ideal-site-for-skin-temperature-probe-placement-on-infants-in-the-nicu-a-review-of-literature
#9
Rachel A Joseph, Sarah Derstine, Michaela Killian
BACKGROUND: Maintaining normothermia and prevention of hypothermia are critical determinants of morbidity and mortality in infants. Noninvasive monitoring of skin temperature using skin temperature probes (STPs) has been a practice in neonatal intensive care units (NICUs) for decades. Incubators and radiant warmers use feedback mechanisms from the STP readings to determine the heat output to maintain normothermia. Placing the STP on an ideal site on the infant's body is essential for optimum servo control of the temperature...
January 12, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28077332/molecular-identification-of-star-and-3%C3%AE-hsd1-and-characterization-in-response-to-gnih-stimulation-in-protogynous-hermaphroditic-grouper-epinephelus-coioides
#10
Qingqing Wang, Xin Qi, Haipei Tang, Yin Guo, Shuisheng Li, Gaofei Li, Xiaoli Yang, Haifa Zhang, Xiaochun Liu, Haoran Lin
Gonadal steroids are critical factors in reproduction and sex reverse process. StAR (steroidogenic acute regulatory protein), transferring the cholesterol from the outer mitochondrial membrane to the inner membrane, is the rate-limiting factor of steroidogenesis. 3βHSD (3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase), converting Δ5-steroids into Δ4-steroids, is an important oxidoreductase in steroidogenesis. In the present study, StAR and 3βHSD1 were cloned and characterized from protogynous orange-spotted grouper...
January 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28075515/the-limitations-of-pulse-oximetry-for-cchd-screening-in-the-nicu
#11
Nithi Fernandes, Satyan Lakshminrusimha
We have read this recently published manuscript by Hu et al(1) regarding using pulse oximetry for screening for critical congenital heart disease (CCHD) in the neonatal intensive care units (NICU) with great interest. As an institution exclusively serving outborn neonates, the study was appropriately designed and executed. Prior published reports of CCHD screening in the NICU report a very low detection rate with pulse oximetry screening. This article is protected by copyright. All rights reserved.
January 11, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28073842/expression-of-cd14-il-10-and-tolerogenic-signature-in-dendritic-cells-inversely-correlate-with-response-to-tarp-vaccination-in-prostate-cancer-patients
#12
Luciano Castiello, Marianna Sabatino, Jiaqiang Ren, Masaki Terabe, Hanh Khuu, Lauren V Wood, Jay A Berzofsky, David F Stroncek
PURPOSE: Despite the vast number of clinical trials conducted so far, Dendritic cell (DC)-based cancer vaccines have mostly shown unsatisfactory results. Factors and manufacturing procedures essential for these therapeutics to induce effective anti-tumor immune responses have yet to be fully characterized. We here aimed to identify DC markers correlating with clinical and immunological response in a prostate carcinoma vaccination regimen. EXPERIMENTAL DESIGN: We performed an extensive characterization of DCs used to vaccinate 18 prostate carcinoma patients enrolled in a pilot trial of TCR gamma alternate reading frame protein (TARP) peptide vaccination (NCT00908258)...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28073736/development-of-an-educational-game-to-set-up-surgical-instruments-on-the-mayo-stand-or-back-table-applied-research-in-production-technology
#13
Crislaine Pires Padilha Paim, Silvia Goldmeier
BACKGROUND: Existing research suggests that digital games can be used effectively for educational purposes at any level of training. Perioperative nursing educators can use games to complement curricula, in guidance and staff development programs, to foster team collaboration, and to give support to critical thinking in nursing practice because it is a complex environment. OBJECTIVE: To describe the process of developing an educational game to set up surgical instruments on the Mayo stand or back table as a resource to assist the instructor in surgical instrumentation training for students and nursing health professionals in continued education...
January 10, 2017: JMIR Serious Games
https://www.readbyqxmd.com/read/28069356/radiology-reports-what-you-think-you-re-saying-and-what-they-think-you-re-saying
#14
Bonmyong Lee, Matthew T Whitehead
BACKGROUND: Image interpretation and translation into written language is an imperfect process. Yet, the radiology report represents the link between radiologist's opinion and patient's images. Increased access to images through remote viewing stations has made direct communication between radiologists and clinicians less commonplace. We are interested in how accurately the descriptive contents within radiology reports convey the feelings of the radiologist to the referring clinician...
November 16, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28065702/molecular-characterization-of-a-p38-mitogen-activated-protein-kinase-gene-from-scylla-paramamosain-and-its-expression-profiles-during-pathogenic-challenge
#15
Zehui Yu, Yi Geng, Anming Huang, Kaiyu Wang, Xiaoli Huang, Defang Chen, Yangping Ou, Jun Wang
A novel p38 MAPK gene from S. paramamosain was cloned and characterized by rapid amplification of cDNA ends (RACE) technology. S. paramamosain p38 (Sp-p38) MAPK gene consists of an open reading frame of 1095 bp encoding a 365-amino-acid protein, which showed close phylogenetic relationship to Litopenaeus vannamei p38 MAPK. The tissue distribution patterns showed that Sp-p38 MAPK was widely expressed in all examined tissues, with the highest expression in hemocytes and intestines. The expression levels of Sp-p38 MAPK in hemocytes was up-regulated post-stimulation, which reached the peak at 6 h and 12h after bacteria (S...
January 5, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28063826/evaluation-of-heat-flux-measurement-as-a-new-pat-monitoring-tool-in-freeze-drying
#16
Ilona Vollrath, Victoria Pauli, Wolfgang Friess, Angelika Freitag, Andrea Hawe, Gerhard Winter
This study investigates the suitability of heat flux measurement as a new technique for monitoring product temperature and critical end points during freeze drying. The heat flux sensor is tightly mounted on the shelf and measures non-invasively (no contact with the product) the heat transferred from shelf to vial. Heat flux data were compared to comparative pressure measurement, thermocouple readings and Karl Fischer titration as current state of the art monitoring techniques. The whole freeze drying process including freezing (both by ramp freezing and controlled nucleation), primary and secondary drying was considered...
January 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28063202/dna-metabarcoding-reveals-that-200-%C3%AE-m-size-fractionated-filtering-is-unable-to-discriminate-between-planktonic-microbial-and-large-eukaryotes
#17
Lemian Liu, Min Liu, David M Wilkinson, Huihuang Chen, Xiaoqing Yu, Yang Jun
Microeukaryotic plankton (0.2-200 μm) are critical components of aquatic ecosystems and key players in global ecological processes. High-throughput sequencing is currently revolutionizing their study on an unprecedented scale. However, it is currently unclear if we can accurately, effectively, and quantitatively depict the microeukaryotic plankton communities using traditional size-fractionated filtering combined with molecular methods. To address this, we analyzed the eukaryotic plankton communities both with, and without, pre-filtering with a 200 μm pore-size sieve - by using SSU rDNA-based high-throughput sequencing on 16 samples with 3 replicates in each sample from two subtropical reservoirs sampled from January to October in 2013...
January 7, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28063033/reproducibility-issues-avoiding-pitfalls-in-animal-inflammation-models
#18
Jon D Laman, Susanne M Kooistra, Björn E Clausen
In light of an enhanced awareness of ethical questions and ever increasing costs when working with animals in biomedical research, there is a dedicated and sometimes fierce debate concerning the (lack of) reproducibility of animal models and their relevance for human inflammatory diseases. Despite evident advancements in searching for alternatives, that is, replacing, reducing, and refining animal experiments-the three R's of Russel and Burch (1959)-understanding the complex interactions of the cells of the immune system, the nervous system and the affected tissue/organ during inflammation critically relies on in vivo models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28061983/the-use-of-novel-oral-anticoagulants-in-cancer-patients-with-venous-thromboembolism
#19
REVIEW
Stamatis J Karakatsanis, Aikaterini Roumpi, Konstantinos N Syrigos
Venous thromboembolism (VTE) is not uncommon among patients with cancer and is one of the major causes of mortality and morbidity. Treatment with low-molecular-weight heparin (LMWH) is effective, yet accompanied by the need for daily administration of injections for a prolonged time and (even rarely) thrombocytopenia. The discovery of novel oral anticoagulants (NOACs) was based on an effort to improve the pharmacodynamic and pharmacokinetic properties of previous generation anticoagulants while maintaining efficacy without the need for daily subcutaneous administration and frequent laboratory monitoring...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28059875/stakeholder-dialogue-as-deliberation-for-decision-making-in-health-policy-and-systems-the-approach-from-argumentation-theory
#20
Sara Rubinelli, Per Maximilian von Groote
OBJECTIVE: The literature on knowledge translation and dissemination in health care highlights the value of the stakeholder dialogue, namely, a structured process where stakeholders interact to identify the best solution to a given problem. By analyzing the stakeholder dialogue as a form of deliberative argumentation, this article identifies those factors that may hinder or facilitate reaching agreement among stakeholders on options to target problems. DESIGN: Conceptual analysis based on the descriptive and evaluation methods of argumentation theory...
February 2017: American Journal of Physical Medicine & Rehabilitation
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