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Adrenocortical carcinoma

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https://www.readbyqxmd.com/read/29671009/interobserver-agreement-in-distinguishing-large-adrenal-adenomas-and-adrenocortical-carcinomas-on-computed-tomography
#1
Aaron J Thomas, Mouhammed A Habra, Priya R Bhosale, Aliya A Qayyum, Kareem Ahmed, Rafael Vicens, Khaled M Elsayes
PURPOSE: Large adrenal masses pose a diagnostic dilemma. The purpose of this study was twofold: first, to assess the degree of interobserver agreement in evaluating the morphology of pathologically proven adrenal adenomas and adrenocortical carcinomas larger than 4 cm in diameter; and second, to identify morphologic characteristics that correlated with the pathologic diagnosis. MATERIALS AND METHODS: For this blinded, retrospective study, we collected cases of 25 adrenal adenomas and 33 adrenocortical carcinomas measuring larger than 4 cm...
April 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29670378/%C3%AE-catenin-driven-adrenocortical-carcinoma-is-characterized-with-immune-exclusion
#2
Shenghua Liu, Guanxiong Ding, Zhongwen Zhou, Chenchen Feng
Aim: Adrenocortical carcinoma (ACC) is characterized by overexpressed CTNNB1 , which is reported to modulate immune exclusion. Cross talk between CTNNB1 and cancer immunity in ACC remains unclear. Materials and methods: In silico reproduction of TCGA-ACC dataset (N = 92) and external validation using tissue samples were performed (N = 16). Expression data of CTNNB1 , PD-1, and PD-L1 were extracted in silico and tumor-infiltrating lymphocytes (TILs) were profiled using code provided by Tumor IMmune Estimation Resource (TIMER)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29667589/a-rare-cause-of-dysregulated-metabolic-syndrome-cortisol-producing-adrenocortical-carcinoma
#3
L Saes, I A Boere, J Hofland, M Mulder, R A Feelders
Adrenocortical carcinoma is a rare and highly malignant disease which can cause hypercortisolism leading to dysregulation of blood pressure and glucose levels. Most patients present with advanced disease. We describe the classic presentation of a functional adrenocortical carcinoma in a patient with metabolic syndrome.
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29665752/histopathologic-findings-in-canine-pituitary-glands
#4
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#5
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29630043/characterization-of-cell-membrane-extensions-and-studying-their-roles-in-cancer-cell-adhesion-dynamics
#6
Taylor C Brown, Norman G Nicolson, Joyce Cheng, Reju Korah, Tobias Carling
The cell membrane's extension repertoire modulates various malignant behaviors of cancer cells, including their adhesive and migratory potentials. The ability to accurately classify and quantify cell extensions and measure the effect on a cell's adhesive capacity is critical to determining how cell-signaling events impact cancer cell behavior and aggressiveness. Here, we describe the in vitro design and use of a cell extension quantification method in conjunction with an adhesion capacity assay in an established in vitro model for adrenocortical carcinoma (ACC)...
March 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29606881/open-adrenalectomy-versus-laparoscopic-adrenalectomy-for-adrenocortical-carcinoma-a-retrospective-comparative-study-on-short-term-oncologic-prognosis
#7
Guo-Yang Zheng, Han-Zhong Li, Jian-Hua Deng, Xue-Bin Zhang, Xing-Cheng Wu
Purpose: Open adrenalectomy (OA) remains the gold standard of surgical therapy for adrenocortical carcinoma, while the role of laparoscopic approach is controversial. We aim to explore the influence of surgical approaches on the oncologic prognosis of adrenocortical carcinoma by comparing the short-term outcomes of patients undergoing OA with those undergoing laparoscopic adrenalectomy (LA). Patients and methods: We retrospectively analyzed the baseline characteristics, perioperative data and short-term prognosis of 42 patients diagnosed with stage I-III adrenocortical carcinoma, receiving OA (n=22) and LA (n=20) as primary therapy...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29581542/detailed-genomic-characterization-identifies-high-heterogeneity-and-histotype-specific-genomic-profiles-in-adrenocortical-carcinomas
#8
Simona Vatrano, Marco Volante, Eleonora Duregon, Jessica Giorcelli, Stefania Izzo, Ida Rapa, Arianna Votta, Antonina Germano, Giorgio Scagliotti, Alfredo Berruti, Massimo Terzolo, And Mauro Papotti
Molecular characterization of adrenocortical carcinoma has been recently established, but the correlation between molecular profiles and clinical and pathological characteristics is still poorly defined with no data available about genetic heterogeneity along disease progression. In this scenario, a detailed molecular profile was correlated with clinical and pathological characteristics in adrenocortical carcinoma patients to identify potentially novel biomarkers. Targeted next-generation sequencing and copy number variation analyses for 18 most frequently altered genes in adrenocortical carcinoma were assessed on 62 adult cases (including 10 with matched primary and metastatic/recurrence samples) and results correlated with major clinical and pathological characteristics of tumors...
March 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29578871/prostate-specific-membrane-antigen-expression-in-adrenocortical-carcinoma-on-68ga-prostate-specific-membrane-antigen-pet-ct
#9
Saurabh Arora, Nishikant Avinash Damle, Sameer Aggarwal, Averilicia Passah, Abhishek Behera, Geetanjali Arora, Chandrasekhar Bal, Madhavi Tripathi
We present here a case of metastatic adrenocortical carcinoma with bilateral lung nodules. The patient had been treated with mitotane therapy initially and then was later referred for chemotherapy. There was progression of disease noted on the F-FDG PET/CT. Ga prostate-specific membrane antigen (PSMA) PET/CT was planned to explore the possibility of future treatment with Lu-DKFZ-PSMA-617. It revealed peripheral increased uptake of Ga-HBED-CC-PSMA equal to liver uptake.
March 24, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29549738/organotin-exposure-stimulates-steroidogenesis-in-h295r-cell-via-camp-pathway
#10
Xueting Yan, Bin He, Lihong Liu, Guangbo Qu, Jianbo Shi, Chunyang Liao, Ligang Hu, Guibin Jiang
Organotin compounds (OTs) are used in a range of industrial products, such as antifouling paints, agricultural pesticides and stabilizers. Owing to potential endocrine-disrupting effects, human exposure to such compounds is a concern. Nevertheless, little is known about the adverse effect of OTs on adrenocortical function in organisms. In this study, the human adrenocortical carcinoma cell (H295R) model was used to investigate effects of OTs on steroidogenesis and potential causes for such endocrine disruption was examined...
March 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29532999/nutlin-3a-as-a-novel-anticancer-agent-for-adrenocortical-carcinoma-with-ctnnb1-mutation
#11
Wen Hui, Shenghua Liu, Jie Zheng, Zujun Fang, Qiang Ding, Chenchen Feng
Adrenocortical carcinoma (ACC) is a rare malignancy, and CTNNB1 is frequently mutated in ACC. Our study aims to screen for effective agents with antineoplastic activity against ACC with CTNNB1 mutation. In-silico screening of the Genomics of Drug Sensitivity in Cancer (GDSC) database was conducted. Drug sensitivity in cells with CTNNB1 mutation was analyzed and further in vitro and in vivo studies were performed using the compound. Only one compound, Nutlin-3a, an MDM2 inhibitor, was significantly sensitive in 18 cancer cells with CTNNB1 mutation...
March 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29524503/autophagy-as-a-compensation-mechanism-participates-in-ethanol-induced-fetal-adrenal-dysfunction-in-female-rats
#12
Hegui Huang, Lian Liu, Jing Li, Chunyan Zhu, Xiaoyu Xie, Ying Ao, Hui Wang
Autophagy plays a vital role in embryonic development and cell differentiation. Our previous study demonstrated that prenatal ethanol exposure (PEE) resulted in intrauterine growth retardation (IUGR) and adrenal developmental toxicities in rat offspring. The present study focused on PEE-induced autophagy as an underlying mechanism and its biological significance in female fetal rats. Female fetuses in the PEE group exhibited lower body weights and suffered adrenal structural abnormalities compared to the controls...
March 7, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29523633/management-of-endocrine-disease-management-of-cushing-s-syndrome-during-pregnancy-solved-and-unsolved-questions
#13
Thierry Brue, Vincent Amodru, Frédéric Castinetti
With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. The predominant cause is adrenal adenoma (sometimes without decreased ACTH), rather than Cushing's disease. There are considerable imaging pitfalls in Cushing's disease...
March 9, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29520253/tcf21-pod-1-a-transcritional-regulator-of-sf-1-nr5a1-as-a-potential-prognosis-marker-in-adult-and-pediatric-adrenocortical-tumors
#14
Barbara Dos Santos Passaia, Matheus Henrique Dias, Jean Lucas Kremer, Sonir Roberto Rauber Antonini, Madson Queiroz de Almeida, Maria Candida Barisson Villares Fragoso, Claudimara Ferini Pacicco Lotfi
With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cells at sites of epithelial-mesenchymal transition during the development of different systems. Adult carcinomas express less TCF21 than adenomas, in addition, the KEGG pathway analysis has shown that BUB1B , among others genes, is negatively correlated with TCF21 expression...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29516499/mir-483-5p-and-mir-139-5p-promote-aggressiveness-by-targeting-n-myc-downstream-regulated-gene-family-members-in-adrenocortical-cancer
#15
Claire Agosta, Jonathan Laugier, Laurent Guyon, Josiane Denis, Jérôme Bertherat, Rossella Libé, Bruno Boisson, Nathalie Sturm, Jean-Jacques Feige, Olivier Chabre, Nadia Cherradi
Adrenocortical carcinoma (ACC) is a tumor with poor prognosis in which overexpression of a panel of microRNAs has been associated with malignancy but a very limited number of investigations on their role in ACC pathogenesis have been conducted. We examined the involvement of miR-483-5p and miR-139-5p in adrenocortical cancer aggressiveness. Using bioinformatics predictions and mRNA/miRNA expression profiles, we performed an integrated analysis to identify inversely correlated miRNA-mRNA pairs in ACC. We identified N-Myc Downstream-Regulated Gene family members 2 and 4 (NDRG2 and NDRG4) as targets of miR-483-5p and miR-139-5p, respectively...
March 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29515971/the-expression-and-prognostic-impact-of-immune-cytolytic-activity-related-markers-in-human-malignancies-a-comprehensive-meta-analysis
#16
Constantinos Roufas, Dimitrios Chasiotis, Anestis Makris, Christodoulos Efstathiades, Christos Dimopoulos, Apostolos Zaravinos
Background: Recently, immune-checkpoint blockade has shown striking clinical results in different cancer patients. However, a significant inter-individual and inter-tumor variability exists among different cancers. The expression of the toxins granzyme A (GZMA) and perforin 1 (PRF1), secreted by effector cytotoxic T cells and natural killer (NK) cells, were recently used as a denominator of the intratumoral immune cytolytic activity (CYT). These levels are significantly elevated upon CD8+ T-cell activation as well as during a productive clinical response against immune-checkpoint blockade therapies...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29507530/the-tyrosine-kinase-inhibitor-nilotinib-is-more-efficient-than-mitotane-in-decreasing-cell-viability-in-spheroids-prepared-from-adrenocortical-carcinoma-cells
#17
Elaine Silveira, Isadora Pontes Cavalcante, Jean Lucas Kremer, Pedro Omori Ribeiro de Mendonça, Claudimara Ferini Pacicco Lotfi
Background: New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of adrenocortical carcinoma cells. Methods: Everolimus, sunitinib, zoledronic acid, imatinib and nilotinib cytotoxicity, alone or combined with mitotane were tested on ACC H295R cells in monolayer or spheroid cultures using MTS assays and confocal microscopy...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29506536/a-case-of-adrenocortical-carcinoma-accompanying-secondary-acute-adrenal-hypofunction-postoperation
#18
Kai Kou, Haiwen Zhang, Conggui Zhang, Enbo Xie, Yuguo Chen, Guangyi Wang, Guoyue Lv
BACKGROUND: Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis. ACCs are classified as functioning and non-functioning. The pathogenesis of ACC remains elusive, and diagnosis of ACC is currently based on pathology. In the absence of other effective approaches, surgical resection is the preferred treatment option. CASE PRESENTATION: Here, we report a case of ACC in the retroperitoneum. The patient underwent radical adrenalectomy and remained disease-free throughout a 6-month follow-up...
March 5, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29500765/impact-of-micro-and-macroscopically-positive-surgical-margins-on-survival-after-resection-of-adrenocortical-carcinoma
#19
Kevin L Anderson, Mohamed A Adam, Samantha M Thomas, Linda Youngwirth, Michael T Stang, Randall P Scheri, Sanziana A Roman, Julie A Sosa
PURPOSE: Adrenocortical carcinoma (ACC) is a rare, aggressive cancer; complete surgical resection offers the best chance for long-term survival. The impact of surgical margin status on survival is poorly understood. Our objective was to determine the association of margin status with survival. METHODS: Patients with ACC were identified from the National Cancer Data Base, 1998-2012, and stratified based on surgical margin status (negative vs. microscopically positive [+] vs...
March 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29475877/management-of-endocrine-disease-adrenocortical-carcinoma-differentiating-the-good-from-the-poor-prognosis-tumors
#20
Anne Jouinot, Jerome Bertherat
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis, the five-years overall survival being below 40%. However there is great variability of outcomes and we have now a better view of the heterogeneity of tumor aggressiveness. The extent of the disease at the time of diagnosis, best assayed by the European Network for the Study of Adrenal Tumors (ENSAT) staging score, is a major determinant of survival. The tumor grade, including the mitotic count and the Ki67 proliferation index, also appears as a strong prognostic factor...
February 23, 2018: European Journal of Endocrinology
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