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https://www.readbyqxmd.com/read/27883227/preterm-infants-exhibited-less-pain-during-a-heel-stick-when-they-were-played-the-same-music-their-mothers-listened-to-during-pregnancy
#1
Lina Kurdahi Badr, Taline Demerjian, Tania Daaboul, Hanan Abbas, Mirvat Hasan Zeineddine, Lama Charafeddine
AIM: Playing music during painful procedures has shown inconsistent benefits for preterm infants. This study observed preterm infants during a heel stick procedure to assess whether listening to the music their mothers listened to during pregnancy had any impact on their pain, physiological and behavioural parameters. METHODS: We randomly exposed 42 preterm infants, with a mean gestational age of 31.8 ±2.79 weeks, to the music their mothers listened to during pregnancy, recorded lullabies and no music, before, during and after a heel stick...
November 24, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27874238/li-ion-synaptic-transistor-for-low-power-analog-computing
#2
Elliot J Fuller, Farid El Gabaly, François Léonard, Sapan Agarwal, Steven J Plimpton, Robin B Jacobs-Gedrim, Conrad D James, Matthew J Marinella, A Alec Talin
Nonvolatile redox transistors (NVRTs) based upon Li-ion battery materials are demonstrated as memory elements for neuromorphic computer architectures with multi-level analog states, "write" linearity, low-voltage switching and low power dissipation. Simulations of backpropagation using the device properties reaches ideal classification accuracy. Physics-based simulations predict energy costs per "write" operation of <10 aJ when scaled to 200 × 200 nm.
November 22, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27852157/acute-and-chronic-effects-of-aquatic-treadmill-training-on-land-treadmill-running-kinematics-a-cross-over-and-single-subject-design-approach
#3
Eadric Bressel, Talin J Louder, James P Hoover, Luke C Roberts, Dennis G Dolny
The aim of this study was to determine if selected kinematic measures (foot strike index [SI], knee contact angle and overstride angle) were different between aquatic treadmill (ATM) and land treadmill (LTM) running, and to determine if these measures were altered during LTM running as a result of 6 weeks of ATM training. Acute effects were tested using 15 competitive distance runners who completed 1 session of running on each treadmill type at 5 different running speeds. Subsequently, three recreational runners completed 6 weeks of ATM training following a single-subject baseline, intervention and withdrawal experiment...
November 17, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27825046/talin-a-potential-protein-biomarker-in-postmortem-investigations
#4
Zahra K Campell, Insu Kwon, Sheree J Finley, Youngil Lee, Gulnaz T Javan
The determination of the postmortem interval is of utmost importance in medicolegal death investigations. There are a number of ways to estimate the postmortem interval; however, the current established methods are susceptible to numerous biotic and abiotic factors. Previously published studies state that protein concentrations in postmortem brain tissues can detect protein changes via immunoblotting and densitometry techniques. The objective of the current study was to determine if there is a correlation between protein expression in cadaver tissues and postmortem interval...
November 2, 2016: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/27816808/talin-and-vinculin-are-downregulated-in-atherosclerotic-plaque-tampere-vascular-study
#5
Magdaléna von Essen, Rolle Rahikainen, Niku Oksala, Emma Raitoharju, Ilkka Seppälä, Ari Mennander, Thanos Sioris, Ivana Kholová, Norman Klopp, Thomas Illig, Pekka J Karhunen, Mika Kähönen, Terho Lehtimäki, Vesa P Hytönen
BACKGROUND AND AIMS: Focal adhesions (FA) play an important role in the tissue remodeling and in the maintenance of tissue integrity and homeostasis. Talin and vinculin proteins are among the major constituents of FAs contributing to cellular well-being and intercellular communication. METHODS: Microarray analysis (MA) and qRT-PCR low-density array were implemented to analyze talin-1, talin-2, meta-vinculin and vinculin gene expression in circulating blood and arterial plaque...
October 15, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27803165/galpha13-switch-region-2-relieves-talin-autoinhibition-to-activate-alphaiibbeta3-integrin
#6
James Schiemer, Andrew Bohm, Li Lin, Glenn Merrill-Skoloff, Robert Flaumenhaft, Jin-Sheng Huang, Guy C Le Breton, Athar H Chishti
Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in quiescent cells. Talin is a large 235 kDa protein comprised of an N-terminal 45 kDa FERM domain, also known as the talin head domain (THD), and a series of helical bundles known as the rod domain. The talin head domain consists of 4 distinct lobes designated as F0-F3...
November 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27783672/the-l-arginine-transporter-solute-carrier-family-7-member-2-mediates-the-immunopathogenesis-of-attaching-and-effacing-bacteria
#7
Kshipra Singh, Nicole T Al-Greene, Thomas G Verriere, Lori A Coburn, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Dana M Hardbower, Alberto G Delgado, M Blanca Piazuelo, Bruce A Vallance, Alain P Gobert, Keith T Wilson
Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens. We assessed the role of SLC7A2 in murine infection with Citrobacter rodentium, an attaching and effacing enteric pathogen that causes colitis. Induction of SLC7A2 was upregulated in colitis tissues, and localized predominantly to colonic epithelial cells. Compared to wild-type mice, Slc7a2-/-mice infected with C. rodentium had improved survival and decreased weight loss, colon weight, and histologic injury; this was associated with decreased colonic macrophages, dendritic cells, granulocytes, and Th1 and Th17 cells...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27775752/health-related-quality-of-life-after-concussion-how-can-we-improve-management-of-care
#8
Douglas R Polster, Christopher C Giza, Talin Babikian
No abstract text is available yet for this article.
October 24, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27775586/hepatitis-b-virus-protein-x-induces-degradation-of-talin-1
#9
Maarten A A van de Klundert, Maartje van den Biggelaar, Neeltje A Kootstra, Hans L Zaaijer
In the infected human hepatocyte, expression of the hepatitis B virus (HBV) accessory protein X (HBx) is essential to maintain viral replication in vivo. HBx critically interacts with the host damaged DNA binding protein 1 (DDB1) and the associated ubiquitin ligase machinery, suggesting that HBx functions by inducing the degradation of host proteins. To identify such host proteins, we systematically analyzed the HBx interactome. One HBx interacting protein, talin-1 (TLN1), was proteasomally degraded upon HBx expression...
October 19, 2016: Viruses
https://www.readbyqxmd.com/read/27775029/protein-kinase-d1-regulates-focal-adhesion-dynamics-and-cell-adhesion-through-phosphatidylinositol-4-phosphate-5-kinase-type-l-%C3%AE
#10
Nisha Durand, Ligia I Bastea, Jason Long, Heike Döppler, Kun Ling, Peter Storz
Focal adhesions (FAs) are highly dynamic structures that are assembled and disassembled on a continuous basis. The balance between the two processes mediates various aspects of cell behavior, ranging from cell adhesion and spreading to directed cell migration. The turnover of FAs is regulated at multiple levels and involves a variety of signaling molecules and adaptor proteins. In the present study, we show that in response to integrin engagement, a subcellular pool of Protein Kinase D1 (PKD1) localizes to the FAs...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27769864/hmgb1-induces-human-non-small-cell-lung-cancer-cell-motility-by-activating-integrin-%C3%AE-v%C3%AE-3-fak-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#11
Jianhua Zhu, Jing Luo, Yongchao Li, Min Jia, Yueqin Wang, Yan Huang, Shuhong Ke
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein with multi-functions and plays an important role in tumorigenesis and metastasis in various human cancers. In the present study, we found that HMGB1 induced migration of in human non-small cell lung cancer (NSCLC) cells by up-regulating integrin αvβ3 expression. Further investigation evidenced that HMGB1 activated Toll-like receptor 4 (TLR4) and NF-κB, which was responsible for αvβ3 up-regulation. Furthermore, HMGB1-induced integrin αvβ3 expression led to focal adhesion kinase (FAK) phosphorylation and increased paxillin and talin mRNA expression...
October 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27760339/the-integrin-lfa-1-controls-t-follicular-helper-cell-generation-and-maintenance
#12
Alexandre P Meli, Ghislaine Fontés, Danielle T Avery, Scott A Leddon, Mifong Tam, Michael Elliot, Andre Ballesteros-Tato, Jim Miller, Mary M Stevenson, Deborah J Fowell, Stuart G Tangye, Irah L King
T follicular helper (Tfh) cells are a CD4(+) T cell subset critical for long-lived humoral immunity. We hypothesized that integrins play a decisive role in Tfh cell biology. Here we show that Tfh cells expressed a highly active form of leukocyte function-associated antigen-1 (LFA-1) that was required for their survival within the germinal center niche. In addition, LFA-1 promoted expression of Bcl-6, a transcriptional repressor critical for Tfh cell differentiation, and inhibition of LFA-1 abolished Tfh cell generation and prevented protective humoral immunity to intestinal helminth infection...
October 18, 2016: Immunity
https://www.readbyqxmd.com/read/27749372/the-role-of-kindlin-in-neutrophil-recruitment-to-inflammatory-sites
#13
Anika Stadtmann, Alexander Zarbock
PURPOSE OF REVIEW: Since the discovery of the lack of kindlin-3 expression as the reason for the immunopathology leukocyte adhesion deficiency III syndrome, the role of kindlin-3 in inflammatory processes was investigated in a numerous studies. This review gives an overview about recent findings regarding the role of kindlin-3 in neutrophil activation and recruitment. RECENT FINDINGS: Kindlin-3, together with talin-1, contributes essentially to the activation of β2-integrins in neutrophils...
January 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27748861/biological-characterization-of-three-immortalized-esophageal-epithelial-cell-lines
#14
Fa-Min Zeng, Yang-Min Xie, Lian-Di Liao, Li-Yan Li, Bo Chen, Jian-Jun Xie, Li-Yan Xu, En-Min Li
The key molecular events that contribute to tumorigenesis are incompletely understood. The aim of the present study was to characterize and compare the biological phenotypes of three human telomerase reverse transcriptase (hTERT) and/or human papillomavirus 16 E6 and E7‑immortalized esophageal epithelial cell lines, NE2‑hTERT (NE2), NE3‑E6E7‑hTERT (NE3) and NEcA6‑E6E7‑hTERT (NEcA6). The present study used soft‑agar colony formation assays, tumorigenicity assays in nude mice, and cell proliferation, adhesion and migration assays to identify the biological characteristics of NE2, NE3 and NEcA6 cells...
October 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27742207/lignin-model-compound-in-alginate-hydrogel-a-strong-antimicrobial-agent-with-high-potential-in-wound-treatment
#15
Dragica Spasojević, Danica Zmejkoski, Jasmina Glamočlija, Miloš Nikolić, Marina Soković, Verica Milošević, Ivana Jarić, Marijana Stojanović, Emilija Marinković, Talin Barisani-Asenbauer, Radivoje Prodanović, Miloš Jovanović, Ksenija Radotić
Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied...
September 30, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27737925/the-integrin-talin-complex-under-force
#16
Jan Neumann, Kay-Eberhard Gottschalk
Integrins are the major transmembrane cellular adhesion receptors. Talin binds to integrins with its head domain and links them to the actin cytoskeleton with its rod domain, acting as the force linkage between the extracellular matrix and the cytoskeleton. It is unknown how forces in different directions affect the integrin-talin complex. We show that small forces applied to the integrin-talin complex breaks a salt bridge between the integrins α- and β-subunit, unlocking the integrin from its resting state...
October 13, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27737911/drosophila-vinculin-is-more-harmful-when-hyperactive-than-absent-and-can-circumvent-integrin-to-form-adhesion-complexes
#17
Aidan P Maartens, Jutta Wellmann, Emma Wictome, Benjamin Klapholz, Hannah Green, Nicholas H Brown
Vinculin is a highly conserved protein involved in cell adhesion and mechanotransduction, and both gain and loss of its activity causes defective cell behaviour. Here, we examine how altering vinculin activity perturbs integrin function within the context of Drosophila development. Whereas loss of vinculin produced relatively minor phenotypes, gain of vinculin activity, via a loss of head-tail autoinhibition, caused lethality. The minimal domain capable of inducing lethality is the talin-binding D1 domain, and this appears to require talin-binding activity, as lethality was suppressed by competition with single vinculin binding sites from talin...
October 13, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27733581/the-tnf-family-member-tl1a-induces-il-22-secretion-in-committed-human-th17-cells-via-il-9-induction
#18
Lisa S Thomas, Stephan R Targan, Masato Tsuda, Qi T Yu, Brenda C Salumbides, Talin Haritunians, Emebet Mengesha, Dermot P B McGovern, Kathrin S Michelsen
TL1A contributes to the pathogenesis of several chronic inflammatory diseases, including those of the bowel by enhancing TH1, TH17, and TH2 responses. TL1A mediates a strong costimulation of these TH subsets, particularly of mucosal CCR9(+) T cells. However, the signaling pathways that TL1A induces in different TH subsets are incompletely understood. We investigated the function of TL1A on human TH17 cells. TL1A, together with TGF-β, IL-6, and IL-23, enhanced the secretion of IL-17 and IFN-γ from human CD4(+) memory T cells...
October 12, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27722656/the-key-position-influence-of-staple-location-on-constrained-peptide-conformation-and-binding
#19
Kelly L Keeling, Okki Cho, Denis B Scanlon, Grant W Booker, Andrew D Abell, Kate L Wegener
Constrained α-helical peptides are showing potential as biological probes and therapeutic agents that target protein-protein interactions. However, the factors that determine the optimal constraint locations are still largely unknown. Using the β-integrin/talin protein interaction as a model system, we examine the effect of constraint location on helical conformation, as well as binding affinity, using circular dichroism and NMR spectroscopy. Stapling increased the overall helical content of each integrin-based peptide tested...
October 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27721497/actomyosin-dependent-dynamic-spatial-patterns-of-cytoskeletal-components-drive-mesoscale-podosome-organization
#20
Marjolein B M Meddens, Elvis Pandzic, Johan A Slotman, Dominique Guillet, Ben Joosten, Svenja Mennens, Laurent M Paardekooper, Adriaan B Houtsmuller, Koen van den Dries, Paul W Wiseman, Alessandra Cambi
Podosomes are cytoskeletal structures crucial for cell protrusion and matrix remodelling in osteoclasts, activated endothelial cells, macrophages and dendritic cells. In these cells, hundreds of podosomes are spatially organized in diversely shaped clusters. Although we and others established individual podosomes as micron-sized mechanosensing protrusive units, the exact scope and spatiotemporal organization of podosome clustering remain elusive. By integrating a newly developed extension of Spatiotemporal Image Correlation Spectroscopy with novel image analysis, we demonstrate that F-actin, vinculin and talin exhibit directional and correlated flow patterns throughout podosome clusters...
October 10, 2016: Nature Communications
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