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Measles vaccine

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https://www.readbyqxmd.com/read/28712666/molecular-surveillance-of-measles-and-rubella-in-the-who-european-region-new-challenges-in-the-elimination-phase
#1
REVIEW
S Santibanez, J M Hübschen, M C Ben Mamou, M Muscat, K E Brown, R Myers, O Donoso Mantke, H Zeichhardt, D Brockmann, S Shulga, C P Muller, P M O'Connor, M N Mulders, A Mankertz
BACKGROUND: TheWHO European Region (EUR) has adopted the goal of eliminating measles and rubella but individual countries perform differently in achieving this goal. Measles virus spread across the EUR by mobile groups has recently led to large outbreaks in the insufficiently vaccinated resident population. As an instrument for monitoring the elimination process and verifying the interruption of endemic virus transmission, molecular surveillance has to provide valid and representative data...
July 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28710608/vaccine-platform-recombinant-measles-virus
#2
REVIEW
Michael D Mühlebach
The classic development of vaccines is lengthy, tedious, and may not necessarily be successful as demonstrated by the case of HIV. This is especially a problem for emerging pathogens that are newly introduced into the human population and carry the inherent risk of pandemic spread in a naïve population. For such situations, a considerable number of different platform technologies are under development. These are also under development for pathogens, where directly derived vaccines are regarded as too complicated or even dangerous due to the induction of inefficient or unwanted immune responses causing considerable side-effects as for dengue virus...
July 14, 2017: Virus Genes
https://www.readbyqxmd.com/read/28709617/mumps-measles-and-rubella-vaccine-for-the-treatment-of-a-recalcitrant-subungual-wart
#3
C Morales-Raya, L Maroñas-Jiménez, R Aragón-Miguel, C Postigo-Llorente
No abstract text is available yet for this article.
July 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28704520/a-self-affirmation-exercise-does-not-improve-intentions-to-vaccinate-among-parents-with-negative-vaccine-attitudes-and-may-decrease-intentions-to-vaccinate
#4
Rachael D Reavis, Jacob B Ebbs, Adaobi K Onunkwo, L Mariah Sage
Two studies investigated the effectiveness of a self-affirmation exercise on vaccine safety beliefs and intent to vaccinate future children. In Study 1, a sample of 585 parents with at least one child under the age of 18 in the home participated through Amazon's MTurk. Participants were randomly assigned to one of four conditions in a 2 x 2 design. Participants read either correcting information refuting a link between the measles, mumps, and rubella (MMR) vaccine and autism or a control passage about bird feeding...
2017: PloS One
https://www.readbyqxmd.com/read/28704350/measles-outbreak-minnesota-april-may-2017
#5
Victoria Hall, Emily Banerjee, Cynthia Kenyon, Anna Strain, Jayne Griffith, Kathryn Como-Sabetti, Jennifer Heath, Lynn Bahta, Karen Martin, Melissa McMahon, Dave Johnson, Margaret Roddy, Denise Dunn, Kristen Ehresmann
On April 10, 2017, the Minnesota Department of Health (MDH) was notified about a suspected measles case. The patient was a hospitalized child aged 25 months who was evaluated for fever and rash, with onset on April 8. The child had no history of receipt of measles-mumps-rubella (MMR) vaccine and no travel history or known exposure to measles. On April 11, MDH received a report of a second hospitalized, unvaccinated child, aged 34 months, with an acute febrile rash illness with onset on April 10. The second patient's sibling, aged 19 months, who had also not received MMR vaccine, had similar symptoms, with rash onset on March 30...
July 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28701757/oncolytic-measles-virus-enhances-antitumour-responses-of-adoptive-cd8-nkg2d-cells-in-hepatocellular-carcinoma-treatment
#6
Aiping Chen, Yonghui Zhang, Gang Meng, Dengxu Jiang, Hailin Zhang, Meihong Zheng, Mao Xia, Aiqin Jiang, Junhua Wu, Christian Beltinger, Jiwu Wei
There is an urgent need for novel effective treatment for hepatocellular carcinoma (HCC). Oncolytic viruses (OVs) not only directly lyse malignant cells, but also induce potent antitumour immune responses. The potency and precise mechanisms of antitumour immune activation by attenuated measles virus remain unclear. In this study, we investigated the potency of the measles virus vaccine strain Edmonston (MV-Edm) in improving adoptive CD8(+)NKG2D(+) cells for HCC treatment. We show that MV-Edm-infected HCC enhanced the antitumour activity of CD8(+)NKG2D(+) cells, mediated by at least three distinct mechanisms...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#7
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare to the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28693082/-study-of-mumps-immunity-after-administrating-measles-mumps-rubella-vaccine-among-children-aged-2-7-years-old-in-jiangsu-province-in-2015
#8
Y B Liu, Y Hu, X Y Deng, Z G Wang, X Sun, P S Lu, H X Guo, F Y Tang, M H Zhou
Objective: To investigate the immunity to mumps after administrating measles-mumps-rubella vaccine (MMR) among children aged 2-7 years old in Jiangsu province in 2015. Methods: A total of 4 190 healthy children aged 2-7 years old, living in local places for at least 3 months, and having been vaccinated at least 1 dose MMR were recruited to the study from Wujin district of Changzhou city, Gaogang district of Taizhou city and Ganyu district of Lianyungang city by using stratified cluster random sampling method between September and November, 2015...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28683781/determinants-of-complete-immunization-among-senegalese-children-aged-12-23%C3%A2-months-evidence-from-the-demographic-and-health-survey
#9
Mouhamed Abdou Salam Mbengue, Moussa Sarr, Adama Faye, Ousseynou Badiane, Fatou Bintou Niang Camara, Souleymane Mboup, Tandakha Ndiaye Dieye
BACKGROUND: The expanded Programme on Immunization (EPI) is one of the most cost-effective interventions to reduce childhood mortality and morbidity. However, determinants of childhood immunization have not been well studied in Senegal. Thus, the aim of our study is to assess routine immunization uptake and factors associated with full immunization status among Senegalese children aged 12-23 months. METHODS: We used the 2010-2011 Senegalese Demographic and Health Survey data...
July 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28673424/measles
#10
REVIEW
William J Moss
Measles is a highly contagious disease that results from infection with measles virus and is still responsible for more than 100 000 deaths every year, down from more than 2 million deaths annually before the introduction and widespread use of measles vaccine. Measles virus is transmitted by the respiratory route and illness begins with fever, cough, coryza, and conjunctivitis followed by a characteristic rash. Complications of measles affect most organ systems, with pneumonia accounting for most measles-associated morbidity and mortality...
June 30, 2017: Lancet
https://www.readbyqxmd.com/read/28673250/risk-factors-for-measles-death-kyegegwa-district-western-uganda-february-september-2015
#11
Richardson Mafigiri, Fred Nsubuga, Alex Riolexus Ario
BACKGROUND: On 18 August 2015, Kyegegwa District reported eight deaths during a measles outbreak to the Uganda Ministry of Health (MoH). We investigated this death cluster to verify the cause, identify risk factors, and inform public health interventions. METHODS: We defined a probable measles case as onset of fever and generalised rash in a Kyegegwa District resident from 1 February - 15 September 2015, plus ≥1 of the following: coryza, conjunctivitis, and cough...
July 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28671426/vaccine-adverse-events-separating-myth-from-reality
#12
Jeanne P Spencer, Ruth H Trondsen Pawlowski, Stephanie Thomas
Vaccines are one of the most successful medical advances in modern times. Most vaccine-preventable illnesses are unfamiliar to modern parents. Because of this, parents are increasingly questioning the necessity of immunizing their children, especially because no vaccine is completely free of adverse effects or the risk of complications. Family physicians should be aware of the risks and benefits of recommended immunizations. Thimerosal is currently used only in multidose vials of influenza vaccine, and exposure through vaccines is not associated with adverse neurologic outcomes...
June 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28669617/an-increasing-potentially-measles-susceptible-population-over-time-after-vaccination-in-korea
#13
Hae Ji Kang, Young Woo Han, Su Jin Kim, You-Jin Kim, A-Reum Kim, Joo Ae Kim, Hee-Dong Jung, Hye Eun Eom, Ok Park, Sung Soon Kim
BACKGROUND: In Korea, measles occurs mainly in infants <12months of age, who are unvaccinated. In addition, vaccine populations, including adolescents and young adults, can become infected though importation. Thus, the question arises whether the current level of herd immunity in Korea is now insufficient for protecting against measles infection. METHODS: Age-specific measles seroprevalence was evaluated by performing enzyme immunoassays and plaque reduction-neutralization tests on 3050 subjects aged 0-50years (birth cohort 1964-2014) and 480 subjects aged 2-30years (birth cohort 1984-2012)...
June 29, 2017: Vaccine
https://www.readbyqxmd.com/read/28666760/vaccination-coverage-among-social-and-healthcare-workers-in-ten-countries-of-samu-social-international-sites
#14
Esaie Marshall, Dominique Salmon, Delphine Laisney, Nadia Bousfiha, Yacouba Togola, François Ouedraogo, Maud Santantonio, Coumba Khadidja Dieng, Suzanne Tartière, Xavier Emmanuelli
BACKGROUND: We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS: Data on immunization coverage of social and healthcare workers were provided by a cross-sectional survey, conducted from February to April 2015 among 252 Samusocial workers in 10 countries. Vaccination status and characteristics of participants were collected through a self-administered questionnaire...
June 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28666265/cap-dependent-translational-control-of-oncolytic-measles-virus-infection-in-malignant-mesothelioma
#15
Blake A Jacobson, Ahad A Sadiq, Shaogeng Tang, Joe Jay-Dixon, Manish R Patel, Jeremy Drees, Brent S Sorenson, Stephen J Russell, Robert A Kratzke
Malignant mesothelioma has a poor prognosis for which there remains an urgent need for successful treatment approaches. Infection with the Edmonston vaccine strain (MV-Edm) derivative of measles virus results in lysis of cancer cells and has been tested in clinical trials for numerous tumor types including mesothelioma. Many factors play a role in MV-Edm tumor cell selectivity and cytopathic activity while also sparing non-cancerous cells. The MV-Edm receptor CD46 (cluster of differentiation 46) was demonstrated to be significantly higher in mesothelioma cells than in control cells...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28662722/yeast-lysates-carrying-the-nucleoprotein-from-measles-virus-vaccine-as-a-novel-subunit-vaccine-platform-to-deliver-plasmodium-circumsporozoite-antigen
#16
Daria Jacob, Claude Ruffie, Chantal Combredet, Pauline Formaglio, Rogerio Amino, Robert Ménard, Frédéric Tangy, Monica Sala
BACKGROUND: Yeast cells represent an established bioreactor to produce recombinant proteins for subunit vaccine development. In addition, delivery of vaccine antigens directly within heat-inactivated yeast cells is attractive due to the adjuvancy provided by the yeast cell. In this study, Pichia pastoris yeast lysates carrying the nucleoprotein (N) from the measles vaccine virus were evaluated as a novel subunit vaccine platform to deliver the circumsporozoite surface antigen (CS) of Plasmodium...
June 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28662695/determinants-of-contraceptive-use-among-postpartum-women-in-a-county-hospital-in-rural-kenya
#17
Rose Jalang'o, Faith Thuita, Sammy O Barasa, Peter Njoroge
BACKGROUND: There is a high unmet need for limiting and spacing child births during the postpartum period. Given the consequences of closely spaced births, and the benefits of longer pregnancy intervals, targeted activities are needed to reach this population of postpartum women. Our objective was to establish the determinants of contraceptive uptake among postpartum women in a county referral hospital in rural Kenya. METHODS: Sample was taken based on a mixed method approach that included both quantitative and qualitative methods of data collection...
June 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28661516/knowledge-attitudes-beliefs-and-practices-of-occupational-physicians-towards-vaccinations-of-health-care-workers-a-cross-sectional-pilot-study-in-north-eastern-italy
#18
Matteo Riccò, Silvia Cattani, Franca Casagranda, Giovanni Gualerzi, Carlo Signorelli
OBJECTIVES: This study aims to characterize personal attitudes and knowledge of a sample of Italian occupational physicians (OPhs) towards immunization practice in the case of healthcare workers (HCWs). MATERIAL AND METHODS: A total of 90 OPhs (42.2% of males, 57.8% of females, mean age of 50.1±8.3 years old) compiled a structured questionnaire through a telephonic interview. They were asked about the official Italian recommendations for HCWs, their general knowledge of vaccine practice, their propensity towards vaccines (both in general and about specific immunizations), their risk perception about the vaccine-preventable infectious diseases...
June 29, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28661392/measles-outbreak-after-12-years-without-endemic-transmission-portugal-february-to-may-2017
#19
Francisco George, João Valente, Gonçalo F Augusto, Andreia J Silva, Natália Pereira, Teresa Fernandes, Paula Palminha, Bárbara A Aguiar, António Martins, Estêvão Santos, Paula Valente, Etelvina Calé, Ana Leça, Paulo J Nogueira
We report a measles outbreak in two Portuguese health regions (Algarve and Lisbon and the Tagus Valley) since February 2017, and which by 31 May resulted in 28 confirmed cases, of which 16 were unvaccinated. Thirteen cases were healthcare workers. One unvaccinated teenager died. Genotype B3 was identified in 14 cases from both regions. This outbreak occurs after 12 years without endemic measles transmission, and in a context of high measles vaccination coverage and immunity.
June 8, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28657894/humoral-immunity-in-arsenic-exposed-children-in-rural-bangladesh-total-immunoglobulins-and-vaccine-specific-antibodies
#20
Rubhana Raqib, Sultan Ahmed, Khalid Bin Ahsan, Maria Kippler, Evana Akhtar, Anjan Kumar Roy, Ying Lu, Shams El Arifeen, Yukiko Wagatsuma, Marie Vahter
BACKGROUND: Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects on humoral immunity. OBJECTIVE: We evaluated whether prenatal and childhood arsenic exposure was associated with humoral immune function in school-aged children. METHODS: Children born in a prospective mother-child cohort in rural Bangladesh were immunized with measles, mumps, and rubella (MMR) vaccines at 9 years of age ()...
June 14, 2017: Environmental Health Perspectives
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