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Ammar Natalwala, Tilo Kunath
Parkinson's disease is a complex and progressive neurodegenerative condition that is characterized by the severe loss of midbrain dopaminergic (mDA) neurons, which innervate the striatum. Cell transplantation therapies to rebuild this dopaminergic network have been attempted for over 30 years. The most promising outcomes were observed when human fetal mesencephalic tissue was used as the source of cells for transplantation. However, reliance on terminations for a Parkinson's therapy presents significant logistical and ethical hurdles...
2017: Progress in Brain Research
Shyam Pujara, Ammar Natalwala, Iain Robertson
Shunt series (SS) X-rays are often performed as additional routine initial investigations for suspected ventriculo-peritoneal shunt dysfunction, despite low diagnostic utility and radiological implications. We reviewed such referrals at our neurosurgical unit and found an 8.3% sensitivity rate for SS; consistent with current evidence. SS should not be performed routinely.
March 10, 2017: British Journal of Neurosurgery
W Yang, I Natalwala, K G Rauf
No abstract text is available yet for this article.
February 2017: Annals of the Royal College of Surgeons of England
Karan Jolly, James Andrew Douglas, Nathan Hamnett, Ibrahim Natalwala, William J C van Niekerk
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Jason Sangha, Ammar Natalwala, Jake Mann, Hardeep Uppal, Sangha Mitra Mummadi, Amirul Haque, Amir Aziz, Rahul Potluri
Stroke is a leading cause of mortality and acquired disability; however, there has been no comprehensive comparison of co-morbid risk factors between different stroke subtypes. The aim of this study was to compare risk factors and mortality for subdural haematoma (SDH), subarachnoid haemorrhage (SAH) and ischaemic and haemorrhagic stroke. We compiled a database of all patients admitted with these conditions to a large teaching hospital in Birmingham, United Kingdom during the period 2000-2007 using the International Classification of Disease (ICD) 10th revision codes...
April 2015: International Journal of Neuroscience
Julia Chackathayil, Jeetesh V Patel, Paramjit S Gill, Rahul Potluri, Ammar Natalwala, Hardeep Uppal, Deepthi Lavu, Reinhard Heun, Elizabeth A Hughes, Gregory Y H Lip
The risk of diabetes is markedly reduced in men with iron deficiency anaemia (IDA). The nature of this relationship in women is not clear, nor is there information about the influence of ethnicity, given the increased susceptibility of diabetes amongst South Asians and Afro-Caribbeans. We reviewed 3563 patients with a diagnosis of anaemia from 2000 to 2007. The age-adjusted prevalence of vitamin B12 deficiency and IDA was calculated, together with cardiovascular comorbidities amongst Caucasians, South Asians, and Afro-Caribbeans...
2013: International Journal of Endocrinology
Narelle Hadlow, Katherine Longhurst, Allison McClements, Jay Natalwala, Suzanne J Brown, Phillip L Matson
OBJECTIVE: To assess the variability of antimüllerian hormone (AMH) concentrations in women with "adequate ovarian reserve" during unstimulated menstrual cycles and to determine the impact on clinical classifications. DESIGN: Pilot cohort study. SETTING: Private fertility clinic. PATIENT(S): Twelve consecutive women (aged 29 to 43 years) referred to a fertility service, with AMH measurements repeated throughout unstimulated cycle, and who had at least one AMH measurement indicating "adequate ovarian reserve...
May 2013: Fertility and Sterility
Harry J C J Bulstrode, Ammar Natalwala, Paul L Grundy
We report four cases of communicating hydrocephalus, requiring shunt placement, in the subset of patients whose ventricles were breached at the time of glioma resection (a total 97 cases over 3 years). The hydrocephalus in these cases presented without ventricular dilatation on computed tomography (CT) scanning, and in 3 cases without headache. Failure to progress, visual deterioration or cerebrospinal fluid (CSF) leak in the post-operative patient after tumour resection with ventricular opening should alert clinicians to the possibility of hydrocephalus, despite the absence of headache or ventriculomegaly, and lumbar puncture should be performed without delay...
April 2012: British Journal of Neurosurgery
R Heun, D Schoepf, R Potluri, A Natalwala
BACKGROUND: Subjects with late-onset Alzheimer's disease (AD) have to be sufficiently healthy to live long enough to experience and to be diagnosed with dementia in later life. In contrast, neurodegeneration and cognitive deficits in AD may increase the frequency of co-morbid disorders and their possible influence on mortality. Consequently, we investigated whether the pattern of co-morbidity and its relevance for later death differed between hospitalized AD and age-matched controls subjects...
January 2013: European Psychiatry: the Journal of the Association of European Psychiatrists
D Schoepf, R Potluri, H Uppal, A Natalwala, P Narendran, R Heun
OBJECTIVE: Physical co-morbidity including type 2 diabetes mellitus is more prevalent in patients with schizophrenia compared to the general population. However, there is little consistent evidence that co-morbidity with diabetes mellitus and/or other diseases leads to excess mortality in schizophrenia. Thus, we investigated whether co-morbidity with diabetes and other somatic diseases is increased in schizophrenics, and if these are equally or more relevant predictors of mortality in schizophrenia than in age- and gender-matched hospitalised controls...
January 2012: European Psychiatry: the Journal of the Association of European Psychiatrists
Ammar Natalwala, Viren Bharkhada, Georges Noel, Garth Cruickshank
BACKGROUND: The aim of this study was to investigate possible delays in referral time for Glioblastoma multiforme (GBM) patients diagnosed at two similar neurosurgical centres (in Birmingham, UK and Strasbourg, France) and their impact on survival. Differences in the referral patterns for GBM patients within these healthcare systems may affect subsequent management and are potential targets to optimise the care of patients with GBM. METHODS: Medical case notes of 105 GBM patients in Birmingham and 81 in Strasbourg, admitted during October 2006 and April 2008, were reviewed...
June 2011: Clinical Neurology and Neurosurgery
M S Dowlut, A Natalwala, H Uppal, R Potluri
No abstract text is available yet for this article.
2009: European Journal of Gynaecological Oncology
R Heun, U Gühne, T Luck, M C Angermeyer, U Ueberham, R Potluri, A Natalwala, T Arendt, S G Riedel-Heller
The presence of Mild Cognitive Impairment (MCI) and of an apolipoprotein E (apoE) varepsilon4 allele both predict the development of Alzheimer's disease. However, the extent to which this allele also predicts the development of MCI is unclear even though MCI is an early transitional stage in the development of Alzheimer's disease. The present study investigates the prevalence of the apoE varepsilon4 allele in incipient MCI. Participants were recruited from the population-based Leipzig Longitudinal Study of the Aged (LEILA75+)...
January 2010: European Psychiatry: the Journal of the Association of European Psychiatrists
Ammar Natalwala, Rahul Potluri, Hardeep Uppal, Reinhard Heun
BACKGROUND: There is a lack of evidence to explain why patients with dementia are admitted to a general hospital. METHODS: Main reasons for hospitalisation were investigated in all patients admitted to a multi-ethnic general hospital during 2002-2007, by analysis of type of admission and primary diagnosis on admission. Anonymised data from the Hospital Activity Analysis Register was used to trace these patients; 505 were diagnosed with Alzheimer's disease (AD), 283 with vascular dementia (VD) and 1,773 patients were classified as unspecified dementia (UnD)...
2008: Dementia and Geriatric Cognitive Disorders
Rahul Potluri, Ammar Natalwala, Hardeep Uppal, Reinhard Heun
No abstract text is available yet for this article.
2009: Neuroepidemiology
Ammar Natalwala, Robert Spychal, Chris Tselepis
Epithelial-mesenchymal transition (EMT) is a highly conserved process that has been well characterised in embryogenesis. Studies have shown that the aberrant activation of EMT in adult epithelia can promote tumour metastasis by repressing cell adhesion molecules, including epithelial (E)-cadherin. Reduced intracellular adhesion may allow tumour cells to disseminate and spread throughout the body. A number of transcription proteins of the Snail superfamily have been implicated in EMT. These proteins have been shown to be over-expressed in advanced gastrointestinal (GI) tumours including oesophageal adenocarcinomas, colorectal carcinomas, gastric and pancreatic cancers, with a concomitant reduction in the expression of E-cadherin...
June 28, 2008: World Journal of Gastroenterology: WJG
John F Donohue, Harbinder Sharma, Raju Abraham, Sirage Natalwala, David R Thomas, Mike C Foster
PURPOSE: Bleeding associated with transurethral prostate resection can often be significant and lead to increased morbidity and occasionally mortality. It has been shown that finasteride decreases bleeding in patients with hematuria of prostatic origin. We hypothesized that bleeding in patients undergoing transurethral prostate resection could be decreased by giving finasteride for 2 weeks before surgery. MATERIALS AND METHODS: A total 70 patients scheduled to undergo elective transurethral prostate resection were randomized to receive 5 mg...
November 2002: Journal of Urology
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