keyword
MENU ▼
Read by QxMD icon Read
search

Sjogren' Syndrome

keyword
https://www.readbyqxmd.com/read/29679709/unique-glandular-ex-vivo-th1-and-th17-receptor-motifs-in-sj%C3%A3-gren-s-syndrome-patients-using-single-cell-analysis
#1
Alexandria Voigt, Katherine Bohn, Sukesh Sukumaran, Carol M Stewart, Indraneel Bhattacharya, Cuong Q Nguyen
Primary Sjögren's syndrome (pSS) is an autoimmune disease in which the underlying cause has yet to be elucidated. The main objective of this study was to determine the T cell receptor (TCR) repertoires of individual infiltrating T helper (Th)-1 and 17 cells of pSS patients using single-cell analysis. Single-cell analysis of ex-vivo infiltrating T cells demonstrated that pSS patients had higher frequencies of activated Th17 cells. Single-cell TCR sequencing revealed that TCRβ variable (TRBV)3-1/joint (J)1-2 (CLFLSMSACVW) and TRBV20-1/J1-1 (SVGSTAIPP*T) were expressed by activated Th1 and Th17 cells in both cohorts...
April 18, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29678847/diagnostic-value-of-vitamin-d-status-and-bone-turnover-markers-in-rheumatoid-arthritis-complicated-by-osteoporosis
#2
Li-Ming Tan, Ting-Ting Long, Xiao-Lin Guan, Si-Fan Wu, Wei Zheng, Hui-Ying Fu, Qiao-Hua Wang, Yi-Mei Meng, Yang Wu, Ting-Ting Zeng, Yong-Jian Tian, Jian-Lin Yu, Juan-Juan Chen, Hua Li, Li-Ping Cao
OBJECTIVE: To research the diagnostic performance of clinical potential bone turnover indexes in rheumatoid arthritis (RA) complicated with osteoporosis (OP). METHODS: This study involved 87 RA patients, 48 with OP, and 39 without OP, and 204 non-RA control patients, including those with systemic lupus erythematosus, ankylosing spondylitis, primary Sjogren's syndrome, systemic sclerosis, and healthy patients. The levels of 25-hydroxyvitamin D [25(OH)D], β-crosslaps (β-CROSSL), parathyroid hormone (PTH) were measured by electrochemiluminescence (ECLIA), and the level of bone alkaline phosphatase (BALP) was measured by lectin affinity method...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29673738/tbk1-a-key-regulator-and-potential-treatment-target-for-interferon-positive-sj%C3%A3-gren-s-syndrome-systemic-lupus-erythematosus-and-systemic-sclerosis
#3
Iris L A Bodewes, Erika Huijser, Cornelia G van Helden-Meeuwsen, Liselotte Tas, Ruth Huizinga, Virgil A S H Dalm, P Martin van Hagen, Noortje Groot, Sylvia Kamphuis, Paul L A van Daele, Marjan A Versnel
OBJECTIVE: Upregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Expression of IFN-I is induced by three different receptor families: Toll-like receptors (TLRs), RIG-like receptors (RLRs) and DNA-sensing receptors (DSRs). TANK-binding kinase (TBK1) is an important signaling hub downstream of RLRs and DSRs. TBK1 activates IRF3 and IRF7, leading to IFN-I production and subsequent induction of interferon stimulated genes (ISGs)...
April 16, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29672805/musculoskeletal-manifestations-of-non-ra-connective-tissue-diseases-scleroderma-systemic-lupus-erythematosus-still-s-disease-dermatomyositis-polymyositis-sj%C3%A3-gren-s-syndrome-and-mixed-connective-tissue-disease
#4
Thibaut Jacques, Iwona Sudoł-Szopińska, Neal Larkman, Phil O'Connor, Anne Cotten
The most common systemic rheumatologic conditions are connective tissue diseases (including rheumatoid arthritis [RA]) followed by spondyloarthropathy. With the advent of biotherapies and imaging biomarkers, development in the imaging of RA and spondyloarthropathies has received substantial attention in the literature. This article details the various musculoskeletal imaging features of the other connective tissue diseases such as scleroderma and progressive systemic sclerosis, systemic lupus erythematosus, Still's disease, dermatomyositis and polymyositis, Sjögren's syndrome, and mixed connective tissue disease...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29671956/atherosclerosis-and-autoimmunity-a-growing-relationship
#5
REVIEW
Maryam Sanjadi, Ziba Rezvanie Sichanie, Hamidreza Totonchi, Jafar Karami, Ramazan Rezaei, Saeed Aslani
Atherosclerosis is regarded as one of the leading causes of mortality and morbidity in the world. Nowadays, it seems that atherosclerosis cannot be defined merely through the Framingham traditional risk factors and that autoimmunity settings exert a remarkable role in its mechanobiology. Individuals with autoimmune disorders show enhanced occurrence of cardiovascular complications and subclinical atherosclerosis. The mechanisms underlying the atherosclerosis in disorders like rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis and Sjögren's syndrome, seem to be the classical risk factors...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29671215/a-patient-presenting-with-isolated-hematuria-and-renal-dysfunction-as-rare-manifestation-of-cryoglobulinemic-glomerulonephritis-in-the-course-of-autoimmune-diseases-including-sj%C3%A3-gren-s-syndrome
#6
Masaki Yamanaka, Yoshihide Fujigaki, Hajime Kono, Michito Nagura, Shigeyuki Arai, Yoshifuru Tamura, Tatsuru Ota, Shigeru Shibata, Fukuo Kondo, Yutaka Yamaguchi, Shunya Uchida
Autoimmune diseases are sometimes associated with immune-mediated renal diseases and cryoglobulinemia is one of the causes. Cryoglobulinemia and cryoglobulinemic glomerulonephritis associated with primary Sjögren's syndrome are most frequent condition among non-hepatitis C virus-related condition. Its typical renal manifestation shows high amount of proteinuria with microscopic hematuria and renal insufficiency. We describe a case of 72-year-old woman with Hashimoto disease, autoimmune hepatitis, Sjögren's syndrome, and immune-related pancytopenia complicated by cryoglobulinemic glomerulonephritis...
April 18, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29670135/clinical-characteristics-and-risk-factors-for-overlapping-rheumatoid-arthritis-and-sj%C3%A3-gren-s-syndrome
#7
Huaxia Yang, Sainan Bian, Hua Chen, Li Wang, Lidan Zhao, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669571/sex-differences-in-pulmonary-arterial-hypertension-role-of-infection-and-autoimmunity-in-the-pathogenesis-of-disease
#8
REVIEW
Kyle A Batton, Christopher O Austin, Katelyn A Bruno, Charles D Burger, Brian P Shapiro, DeLisa Fairweather
Registry data worldwide indicate an overall female predominance for pulmonary arterial hypertension (PAH) of 2-4 over men. Genetic predisposition accounts for only 1-5% of PAH cases, while autoimmune diseases and infections are closely linked to PAH. Idiopathic PAH may include patients with undiagnosed autoimmune diseases based on the relatively high presence of autoantibodies in this group. The two largest PAH registries to date report a sex ratio for autoimmune connective tissue disease-associated PAH of 9:1 female to male, highlighting the need for future studies to analyze subgroup data according to sex...
April 18, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29669457/sleep-apnea-in-sj%C3%A3-gren-s-syndrome-potentially-influences-the-eular-sj%C3%A3-gren-s-syndrome-patient-reported-index
#9
Maike Jülich, Stephan Budweiser, Jan Thoden, Reinhard E Voll, Florian Kollert
No abstract text is available yet for this article.
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29669392/ectopic-germinal-centre-like-structures-in-minor-salivary-gland-biopsy-predict-lymphoma-occurrence-in-patients-with-primary-sj%C3%A3-gren-syndrome
#10
Damien Sène, Sophie Ismael, Marine Forien, Frédéric Charlotte, Rachid Kaci, Patrice Cacoub, Diallo Abdourahmane, Philippe Dieudé, Frédéric Lioté
OBJECTIVE: The objective was to determine risk factors of pSS-associated lymphoma in a multicenter cohort of patients, including in analyzed variables the presence of including ectopic germinal centre-like structures in minor salivary gland biopsy (MSGB). PATIENTS AND METHODS: 115 pSS-patients were included and their MSGB were retrospectively examined focusing on the presence of ectopic germinal centre-like structures. Epidemiological, clinical, biological, immunological and histological data were collected at pSS diagnosis...
April 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29667944/proximal-muscle-weakness-with-overlying-hypokalemic-periodic-paralysis-in-sj%C3%A3-gren-syndrome-report-of-6-cases
#11
Vimal K Paliwal, Anmol Singh Rai, Surendra Kumar, Ritu Verma, Vikas Agarwal
No abstract text is available yet for this article.
April 5, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29666604/the-association-of-sj%C3%A3-gren-syndrome-and-autoimmune-thyroid-disorders
#12
REVIEW
Chiara Baldini, Francesco Ferro, Marta Mosca, Poupak Fallahi, Alessandro Antonelli
Sjögren's syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS-AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa . Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD-SS association...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29666155/sil1-the-er-hsp70-co-chaperone-plays-a-critical-role-in-maintaining-skeletal-muscle-proteostasis-and-physiology
#13
Viraj P Ichhaporia, Jieun Kim, Kanisha Kavdia, Peter Vogel, Linda Horner, Sharon Frase, Linda M Hendershot
Mutations in SIL1 , a co-factor for the endoplasmic reticular (ER) chaperone BiP, cause Marinesco-Sjögren syndrome (MSS), an autosomal recessive disorder. Using a mouse model, we characterized molecular aspects of the progressive myopathy associated with MSS. Proteomic-profiling of quadriceps at the onset of myopathy revealed that SIL1 deficiency affected multiple pathways critical to muscle physiology. We observed an increase in ER chaperones prior to the onset of muscle weakness, which was complemented by up-regulation of multiple components of cellular protein degradation pathways...
April 9, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29665238/cp-25-alleviates-experimental-sj%C3%A3-gren-s-syndrome-features-in-nod-ltj-mice-and-modulates-t-lymphocyte-subsets
#14
Fang Gu, Shixia Xu, Pengying Zhang, Xiaoyun Chen, Yujing Wu, Chun Wang, Mei Gao, Min Si, Xinming Wang, Korner Heinrich, Huaxun Wu, Wei Wei
Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune illness of the moisture-producing glands such as salivary glands that is characterized by various immune abnormalities. The aetiology of pSS remains unclear and there is no curative agent. In this study, we investigated the putative therapeutic effects on a NOD/Ltj mouse model of Sjögren's syndrome-like disorders of an ester derivative of paeoniflorin, Paeoniflorin-6'O-benzene (termed CP-25). Our study showed that CP-25 alleviated effectively clinical manifestations in NOD/Ltj mice resulting for example in increased salivary flow and reduced histopathological scores...
April 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29663717/salivary-gland-stem-cells-a-review-of-development-regeneration-and-cancer
#15
REVIEW
Elaine Emmerson, Sarah M Knox
Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the reactivation of endogenous stem cells or the transplant of exogenous stem cells hold substantial promise in restoring the structure and function of these organs to improve patient quality of life. However, these approaches have been hampered by a lack of knowledge on the identity of salivary stem cell populations and their regulators...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29663342/associations-of-chronic-urticaria-with-atopic-and-autoimmune-comorbidities-a-nationwide-population-based-study
#16
Hsien-Yi Chiu, Chih-Hsin Muo, Fung-Chang Sung
BACKGROUND: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. OBJECTIVES: This study aims to examine the association between CU, and atopic and autoimmune diseases. METHODS: This population-based retrospective cohort study identified 9,332 patients with CU and 37,328 controls matched for age, sex, and number of dermatological clinic visits from the Taiwan National Health Insurance Research Database for 2004-2009...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29663334/the-rheumatic-disease-associated-fam167a-blk-locus-encodes-diora-1-a-novel-disordered-protein-highly-expressed-in-bronchial-epithelium-and-alveolar-macrophages
#17
Lara Mentlein, Gudny Ella Thorlacius, Lauro Meneghel, Lara A Aqrawi, Jorge I Ramírez Sepúlveda, Johan Grunewald, Alexander Espinosa, Marie Wahren-Herlenius
OBJECTIVES: Triggering of autoimmunity that leads to rheumatic disease has been suggested to depend on gene-environment interactions occurring in epithelial barriers and associated immune cells. Genetic studies have identified associations of the FAM167A-BLK locus with rheumatoid arthritis, SLE, and Sjögren's syndrome. While BLK (B lymphocyte kinase) has a well-established role in B cells, family with sequence similarity 167 member A (FAM167A) and its gene family remain uncharacterized...
April 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29662487/acquisition-of-n-glycosylation-sites-in-immunoglobulin-heavy-chain-genes-during-local-expansion-in-parotid-salivary-glands-of-primary-sj%C3%A3-gren-patients
#18
Annie Visser, Marieke E Doorenspleet, Niek de Vries, Fred K L Spijkervet, Arjan Vissink, Richard J Bende, Hendrika Bootsma, Frans G M Kroese, Nicolaas A Bos
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjögren's syndrome (pSS) patients. In this study, next generation sequencing was used to study the extent of ac-Nglycs among clonally expanded cells from all IGVH families in the salivary glands of pSS patients. RNA was isolated from parotid gland biopsies of five pSS patients and five non-pSS sicca controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29657585/deterioration-in-saliva-quality-in-patients-with-sj%C3%A3-gren-s-syndrome-impact-of-decrease-in-salivary-epidermal-growth-factor-on-the-severity-of-intraoral-manifestations
#19
REVIEW
Naoto Azuma, Yoshinori Katada, Hajime Sano
Background: Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland dysfunction, most patients with SS have xerostomia related to a reduced salivary flow rate. In addition to the discomfort due to xerostomia, dry mouth can cause various intraoral manifestations such as refractory stomatitis, ulcer, and atrophic changes in the oral mucosa and tongue, and the patient's quality of life (QoL) is severely impaired...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29657352/experience-of-sleep-disruption-in-primary-sj%C3%A3-gren-s-syndrome-a-focus-group-study
#20
Katie L Hackett, Vincent Deary, Katherine Ho Deane, Julia L Newton, Wan-Fai Ng, Tim Rapley
Introduction: Primary Sjögren's syndrome is the third most common systemic autoimmune rheumatic disease, following rheumatoid arthritis and systemic lupus erythematosus, and results in dryness, fatigue, discomfort and sleep disturbances. Sleep is relatively unexplored in primary Sjögren's syndrome. We investigated the experiences of sleep disturbances from the viewpoint of primary Sjögren's syndrome patients and their partners and explored the acceptability of cognitive behavioural therapy for insomnia...
April 2018: British Journal of Occupational Therapy
keyword
keyword
50063
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"