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https://www.readbyqxmd.com/read/28749484/communication-related-allegations-against-physicians-caring-for-premature-infants
#1
J Nguyen, H Muniraman, M Cascione, R Ramanathan
OBJECTIVE: Maternal-fetal medicine physicians (MFMp) and neonatal-perinatal medicine physicians (NPMp) caring for premature infants and their families are exposed to significant risk for malpractice actions. Effective communication practices have been implicated to decrease litigious intentions but the extent of miscommunication as a cause of legal action is essentially unknown in this population. Analysis of communication-related allegations (CRAs) may help toward improving patient care and physician-patient relationships as well as decrease litigation risks...
July 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28749474/racial-ethnic-differences-in-multiple-gene-sequencing-results-for-hereditary-cancer-risk
#2
Jennifer L Caswell-Jin, Tanya Gupta, Evan Hall, Iva M Petrovchich, Meredith A Mills, Kerry E Kingham, Rachel Koff, Nicolette M Chun, Peter Levonian, Alexandra P Lebensohn, James M Ford, Allison W Kurian
PurposeWe examined racial/ethnic differences in the usage and results of germ-line multiple-gene sequencing (MGS) panels to evaluate hereditary cancer risk.MethodsWe collected genetic testing results and clinical information from 1,483 patients who underwent MGS at Stanford University between 1 January 2013 and 31 December 2015.ResultsAsians and Hispanics presented for MGS at younger ages than whites (48 and 47 vs. 55; P = 5E-16 and 5E-14). Across all panels, the rate of pathogenic variants (15%) did not differ significantly between racial groups...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749412/multi-targeting-andrographolide-a-novel-nf-%C3%AE%C2%BAb-inhibitor-as-a-potential-therapeutic-agent-for-stroke
#3
REVIEW
Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, Thanasekaran Jayakumar
A key focus in the field of drug discovery has been motivated by the neuroprotection of natural compounds. Cerebral ischemia is a multifaceted pathological process with a series of mechanisms, and a perspective for the development of neuroprotectants from traditional herbal medicine or natural products is a promising treatment for this disease. Natural compounds with the effects of anti-oxidation, anti-inflammation, anti-apoptosis, and neurofunctional regulation exhibit therapeutic effects on experimental ischemic brain injury...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749296/bridging-gaps-between-zoo-and-wildlife-medicine-establishing-reference-intervals-for-free-ranging-african-lions-panthera-leo
#4
Heather M Broughton, Danny Govender, Purvance Shikwambana, Patrick Chappell, Anna Jolles
The International Species Information System has set forth an extensive database of reference intervals for zoologic species, allowing veterinarians and game park officials to distinguish normal health parameters from underlying disease processes in captive wildlife. However, several recent studies comparing reference values from captive and free-ranging animals have found significant variation between populations, necessitating the development of separate reference intervals in free-ranging wildlife to aid in the interpretation of health data...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749051/genomic-justice-and-imagined-communities
#5
Ernesto Schwartz-Marin
In this issue of the Hastings Center Report, Maya Sabatello and Paul Appelbaum explore the assumptions about community embedded in the U.S. Precision Medicine Initiative, which aims to recruit donor-partners who reflect the United States' racial and ethnic diversity. As Sabatello and Appelbaum discuss, the initiative is like other national biobanking efforts in bringing to life an imagined genetic community in need of critical attention, and given the public-private forms of partnership at the heart of the PMI, such efforts could become avenues to deepen existing inequalities rather than to alleviate them...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28749016/trends-in-study-design-and-the-statistical-methods-employed-in-a-leading-general-medicine-journal
#6
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
July 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28748278/-therapy-escalation-for-the-potential-organ-donor-are-all-intensive-care-measures-also-ethically-justifiable
#7
REVIEW
S-O Kuhn, K Hahnenkamp
The gap between the number of organs needed and the number available has dramatically increased in Germany in the last decade-for intensivists and transplantation specialists, it is challenging to cover the demand responsibly. It is therefore increasingly important to identify potential organ donors in order to realize organ donation. An escalation of intensive care measures is often required, which raises critical ethical questions. In Germany, organ donation is only allowed after brain death with prior informed consent from the deceased or his/her relatives...
July 26, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28748196/developing-interactive-antimicrobial-stewardship-and-infection-prevention-curricula-for-diverse-learners-a-tailored-approach
#8
Priya Nori, Theresa Madaline, Iona Munjal, Shubha Bhar, Yi Guo, Susan K Seo, Andrea Porrovecchio, Elizabeth Gancher, Joshua Nosanchuk, Liise-Anne Pirofski, Belinda Ostrowsky
BACKGROUND: To impart principles of antimicrobial stewardship (AS) and infection prevention and control (IPC), we developed a curriculum tailored to the diverse aptitudes of learners at our medical center. METHODS: We integrated case-based modules, group learning activities, smartphone applications (apps), decision support tools, and prescription audit and feedback into curricula of the medical school, medicine residency program, infectious diseases (ID) fellowship program, and hospital medicine program operations...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28748106/a-feasibility-study-of-a-theory-based-intervention-to-improve-appropriate-polypharmacy-for-older-people-in-primary-care
#9
Cathal A Cadogan, Cristín Ryan, Gerard J Gormley, Jill J Francis, Peter Passmore, Ngaire Kerse, Carmel M Hughes
BACKGROUND: A general practitioner (GP)-targeted intervention aimed at improving the prescribing of appropriate polypharmacy for older people was previously developed using a systematic, theory-based approach based on the UK Medical Research Council's complex intervention framework. The primary intervention component comprised a video demonstration of a GP prescribing appropriate polypharmacy during a consultation with an older patient. The video was delivered to GPs online and included feedback emphasising the positive outcomes of performing the behaviour...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28747291/dental-blogs-podcasts-and-associated-social-media-descriptive-mapping-and-analysis
#10
Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott
BACKGROUND: Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. OBJECTIVE: The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry...
July 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28747237/mental-health-care-utilisation-among-internally-displaced-persons-in-ukraine-results-from-a-nation-wide-survey
#11
B Roberts, N Makhashvili, J Javakhishvili, A Karachevskyy, N Kharchenko, M Shpiker, E Richardson
Aims There are an estimated 1.5 million internally displaced persons (IDPs) in Ukraine because of the armed conflict in the east of the country. The aim of this paper is to examine utilisation patterns of mental health and psychosocial support (MHPSS) care among IDPs in Ukraine. METHODS: A cross-sectional survey design was used. Data were collected from 2203 adult IDPs throughout Ukraine between March and May 2016. Data on mental health care utilisation were collected, along with outcomes including post-traumatic stress disorder (PTSD), depression and anxiety...
July 27, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28747168/the-biobank-for-the-molecular-classification-of-kidney-disease-research-translation-and-precision-medicine-in-nephrology
#12
Daniel A Muruve, Michelle C Mann, Kevin Chapman, Josee F Wong, Pietro Ravani, Stacey A Page, Hallgrimur Benediktsson
BACKGROUND: Advances in technology and the ability to interrogate disease pathogenesis using systems biology approaches are exploding. As exemplified by the substantial progress in the personalized diagnosis and treatment of cancer, the application of systems biology to enable precision medicine in other disciplines such as Nephrology is well underway. Infrastructure that permits the integration of clinical data, patient biospecimens and advanced technologies is required for institutions to contribute to, and benefit from research in molecular disease classification and to devise specific and patient-oriented treatments...
July 26, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28747053/eluxadoline-in-the-treatment-of-diarrhea-predominant-irritable-bowel-syndrome-the-sepd-perspective
#13
Isabel Vera, F Javier Júdez
Functional gut disorders, including diarrhea-predominant irritable bowel syndrome, are highly prevalent conditions worldwide that significantly impact health economy and patient quality of life, yet lacking fully satisfactory therapeutic options. These circumstances fostered research on various molecules with more specific therapeutic targets, including opioid receptors. Eluxadoline (Allergan's Vibercy® in the USA, Truberzi® in Europe) is a locally-acting mixed - and -opioid receptor agonist, and -opioid receptor antagonist, that was licensed in 2015 by the Food and Drug Administration (FDA) and in 2016 by the European Medicines Agency (EMA) for use in diarrhea-predominant irritable bowel syndrome...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28746312/sequencing-and-de-novo-assembly-of-150-genomes-from-denmark-as-a-population-reference
#14
Lasse Maretty, Jacob Malte Jensen, Bent Petersen, Jonas Andreas Sibbesen, Siyang Liu, Palle Villesen, Laurits Skov, Kirstine Belling, Christian Theil Have, Jose M G Izarzugaza, Marie Grosjean, Jette Bork-Jensen, Jakob Grove, Thomas D Als, Shujia Huang, Yuqi Chang, Ruiqi Xu, Weijian Ye, Junhua Rao, Xiaosen Guo, Jihua Sun, Hongzhi Cao, Chen Ye, Johan van Beusekom, Thomas Espeseth, Esben Flindt, Rune M Friborg, Anders E Halager, Stephanie Le Hellard, Christina M Hultman, Francesco Lescai, Shengting Li, Ole Lund, Peter Løngren, Thomas Mailund, Maria Luisa Matey-Hernandez, Ole Mors, Christian N S Pedersen, Thomas Sicheritz-Pontén, Patrick Sullivan, Ali Syed, David Westergaard, Rachita Yadav, Ning Li, Xun Xu, Torben Hansen, Anders Krogh, Lars Bolund, Thorkild I A Sørensen, Oluf Pedersen, Ramneek Gupta, Simon Rasmussen, Søren Besenbacher, Anders D Børglum, Jun Wang, Hans Eiberg, Karsten Kristiansen, Søren Brunak, Mikkel Heide Schierup
Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotypic traits. Genetic variation is identified mainly by mapping short reads to the reference genome or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high-coverage sequencing with mate-pair libraries extending up to 20 kilobases...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28745941/veterans-preferences-for-remote-management-of-chronic-conditions
#15
Erica Sedlander, Katherine C Barboza, Ashley Jensen, Nicole Skursky, Katelyn Bennett, Scott Sherman, Mark Schwartz
BACKGROUND: The Veterans Health Administration (VA) is investing considerable resources into providing remote management care to patients for disease prevention and management. Remote management includes online patient portals, e-mails between patients and providers, follow-up phone calls, and home health devices to monitor health status. However, little is known about patients' attitudes and preferences for this type of care. This qualitative study was conducted to better understand patient preferences for receiving remote care...
July 26, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28745564/patient-and-clinician-perspectives-of-an-integrated-electronic-medication-prescribing-and-dispensing-system-a-qualitative-study-at-a-multisite-australian-hospital-network
#16
Grace Lau, Jayde Ho, Susan Lin, Karen Yeoh, Tiffany Wan, Marisa Hodgkinson
BACKGROUND: While clinician attitudes towards electronic prescribing (e-prescribing) systems have been widely studied, little is known about the perspectives of patients, despite being the primary beneficiaries of these systems. OBJECTIVE: The objective of this study is to explore and compare patient and clinician attitudes towards an integrated e-prescribing and dispensing system, in order to guide improvements in system implementation, service delivery and enhancements to system functionality...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28745447/commentary-perspectives-on-alcohol-related-gene-and-environment-interplay-in-diverse-populations
#17
Marcia S Scott
BACKGROUND AND OBJECTIVES: Racial/ethnic groups comprise more than 20% of the U.S. population, but many experience disproportionately high risk for alcohol misuse, often resulting in higher rates of alcohol-associated consequences. Completion of mapping the human genome has launched rapidly evolving research methods aimed at improved understanding of genetic contribution to disease. Despite decades of research on the influence of genetic and environmental risks on alcohol use disorders and outcomes, few studies have included racial/ethnic subpopulations in sufficient numbers to allow for proper statistical analysis...
August 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28745409/assessment-of-reynolds-stress-components-and-turbulent-pressure-loss-using-4d-flow-mri-with-extended-motion-encoding
#18
Henrik Haraldsson, Sarah Kefayati, Sinyeob Ahn, Petter Dyverfeldt, Jonas Lantz, Matts Karlsson, Gerhard Laub, Tino Ebbers, David Saloner
PURPOSE: To measure the Reynolds stress tensor using 4D flow MRI, and to evaluate its contribution to computed pressure maps. METHODS: A method to assess both velocity and Reynolds stress using 4D flow MRI is presented and evaluated. The Reynolds stress is compared by cross-sectional integrals of the Reynolds stress invariants. Pressure maps are computed using the pressure Poisson equation-both including and neglecting the Reynolds stress. RESULT: Good agreement is seen for Reynolds stress between computational fluid dynamics, simulated MRI, and MRI experiment...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28745402/fat-based-registration-of-breast-dynamic-contrast-enhanced-water-images
#19
Subashini Srinivasan, Brian A Hargreaves, Bruce L Daniel
PURPOSE: In this study, a 3D fat-based deformable registration algorithm was developed for registering dynamic contrast-enhanced breast images. METHODS: The mutual information similarity measure with free-form deformation motion correction in rapidly enhancing lesions can introduce motion. However, in Dixon-based fat-water separated acquisitions, the nonenhancing fat signal can directly be used to estimate deformable motion, which can be later used to deform the water images...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28745081/ethnobotanical-ethnopharmacological-and-phytochemical-studies-of-myrtus-communis-linn-a-popular-herb-in-unani-system-of-medicine
#20
Mekonnen Sisay, Tigist Gashaw
Myrtus communis L (Myrtaceae) is one of the popular drugs being used in the Unani system of phytomedicine since ancient Greece period. From time immemorial, different parts of this plant and essential oil have been used for a variety of purposes such as cosmetics (hair fall control), flavoring of food and drinks as well as extensive therapeutic purposes. Ethnobotanical information revealed that M communis L has been a folkloric repute for the treatment of several diseases like gastric ulcer, diarrhea, dysentery, cancer, rheumatism, hemorrhage, deep sinuses, leucorrhoea, hemorrhoid, inflammation, dyspepsia, anxiety, insomnia, diabetes, hypertension, pulmonary disorders, and skin diseases...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
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