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https://www.readbyqxmd.com/read/28227033/advanced-analytics-for-outcome-prediction-in-intensive-care-units
#1
Ali Jalali, Dieter Bender, Mohamed Rehman, Vinay Nadkanri, C Nataraj, Ali Jalali, Dieter Bender, Mohamed Rehman, Vinay Nadkanri, C Nataraj, Mohamed Rehman, Ali Jalali, Vinay Nadkanri, Dieter Bender, C Nataraj
In this paper we present a new expert knowledge based clinical decision support system for prediction of intensive care units outcome based on the physiological measurements collected during the first 48 hours of the patient's admission to the ICU. The developed CDSS algorithm is composed of several stages. First, we categorize the collected data based on the physiological organ that they represent. We then extract clinically relevant features from each data category and then rank these features based on their mutual information with the outcome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226770/a-multiscale-model-based-analysis-of-the-multi-tissue-interplay-underlying-blood-glucose-regulation-in-type-i-diabetes
#2
Federico Wadehn, Stephan Schaller, Thomas Eissing, Markus Krauss, Lars Kupfer, Federico Wadehn, Stephan Schaller, Thomas Eissing, Markus Krauss, Lars Kupfer, Federico Wadehn, Markus Krauss, Lars Kupfer, Stephan Schaller, Thomas Eissing
A multiscale model for blood glucose regulation in diabetes type I patients is constructed by integrating detailed metabolic network models for fat, liver and muscle cells into a whole body physiologically-based pharmacokinetic/pharmacodynamic (pBPK/PD) model. The blood glucose regulation PBPK/PD model simulates the distribution and metabolization of glucose, insulin and glucagon on an organ and whole body level. The genome-scale metabolic networks in contrast describe intracellular reactions. The developed multiscale model is fitted to insulin, glucagon and glucose measurements of a 48h clinical trial featuring 6 subjects and is subsequently used to simulate (in silico) the influence of geneknockouts and drug-induced enzyme inhibitions on whole body blood glucose levels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226266/parallel-artificial-liquid-membrane-extraction-of-new-psychoactive-substances-in-plasma-and-whole-blood
#3
Linda Vårdal, Hilde-Merete Askildsen, Astrid Gjelstad, Elisabeth Leere Øiestad, Hilde Marie Erøy Edvardsen, Stig Pedersen-Bjergaard
Parallel artificial liquid membrane extraction (PALME) was combined with ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) and the potential for screening of new psychoactive substances (NPS) was investigated for the first time. PALME was performed in 96-well format comprising a donor plate, a supported liquid membrane (SLM), and an acceptor plate. Uncharged NPS were extracted from plasma or whole blood, across an organic SLM, and into an aqueous acceptor solution, facilitated by a pH gradient...
February 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28225213/a-dual-organic-transistor-based-tactile-perception-system-with-signal-processing-functionality
#4
Yaping Zang, Hongguang Shen, Dazhen Huang, Chong-An Di, Daoben Zhu
Organic-device-based tactile-perception systems can open up new opportunities for the next generation of intelligent products. To meet the critical requirements of artificial perception systems, the efficient construction of organic smart elements with integrated sensing and signal processing functionalities is highly desired, but remains a challenge. This study presents a dual-organic-transistor-based tactile-perception element (DOT-TPE) with biomimetic functionality by the construction of organic synaptic transistors with integrated sensing transistors...
February 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28222194/forecasting-outpatient-visits-using-empirical-mode-decomposition-coupled-with-back-propagation-artificial-neural-networks-optimized-by-particle-swarm-optimization
#5
Daizheng Huang, Zhihui Wu
Accurately predicting the trend of outpatient visits by mathematical modeling can help policy makers manage hospitals effectively, reasonably organize schedules for human resources and finances, and appropriately distribute hospital material resources. In this study, a hybrid method based on empirical mode decomposition and back-propagation artificial neural networks optimized by particle swarm optimization is developed to forecast outpatient visits on the basis of monthly numbers. The data outpatient visits are retrieved from January 2005 to December 2013 and first obtained as the original time series...
2017: PloS One
https://www.readbyqxmd.com/read/28218920/a-non-volatile-organic-electrochemical-device-as-a-low-voltage-artificial-synapse-for-neuromorphic-computing
#6
Yoeri van de Burgt, Ewout Lubberman, Elliot J Fuller, Scott T Keene, Grégorio C Faria, Sapan Agarwal, Matthew J Marinella, A Alec Talin, Alberto Salleo
The brain is capable of massively parallel information processing while consuming only ∼1-100 fJ per synaptic event. Inspired by the efficiency of the brain, CMOS-based neural architectures and memristors are being developed for pattern recognition and machine learning. However, the volatility, design complexity and high supply voltages for CMOS architectures, and the stochastic and energy-costly switching of memristors complicate the path to achieve the interconnectivity, information density, and energy efficiency of the brain using either approach...
February 20, 2017: Nature Materials
https://www.readbyqxmd.com/read/28218442/template-free-growth-of-well-ordered-silver-nano-forest-ceramic-metamaterial-films-with-tunable-optical-responses
#7
Junhua Gao, Xingzhi Wu, Qiuwu Li, Shiyu Du, Feng Huang, Lingyan Liang, Hongliang Zhang, Fei Zhuge, Hongtao Cao, Yinglin Song
Currently, the limitations of conventional methods for fabricating metamaterials composed of well-aligned nanoscale inclusions either lack the necessary freedom to tune the structural geometry or are difficult for large-area synthesis. In this Communication, the authors propose a fabrication route to create well-ordered silver nano forest/ceramic composite single-layer or multi-layer vertically stacked structures, as a distinctive approach to make large-area nanoscale metamaterials. To take advantage of direct growth, the authors fabricate single-layer nanocomposite films with a well-defined sub-5 nm interwire gap and an average nanowire diameter of ≈3 nm...
February 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28216437/extracellular-eosinophilic-traps-in-association-with-staphylococcus-aureus-at-the-site-of-epithelial-barrier-defects-in-severe-airway-inflammation
#8
Elien Gevaert, Nan Zhang, Olga Krysko, Feng Lan, Gabriële Holtappels, Natalie De Ruyck, Hans Nauwynck, Shida Yousefi, Hans-Uwe Simon, Claus Bachert
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a Th2-biased eosinophilic inflammation. Eosinophils have been shown to generate so-called extracellular eosinophilic traps (EETs) under similar pathological conditions. OBJECTIVE: Our aim was to investigate a possible link between EET formation and the presence of Staphylococcus aureus, an organism frequently colonizing the upper airways, at the human mucosal site of the disease. METHODS: Tissue slides were investigated for the presence of EETs and S...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28215801/differences-in-dom-of-rewetted-and-natural-peatlands-results-from-high-field-ft-icr-ms-and-bulk-optical-parameters
#9
Peter Herzsprung, Katja Osterloh, Wolf von Tümpling, Mourad Harir, Norbert Hertkorn, Philippe Schmitt-Kopplin, Ralph Meissner, Sabine Bernsdorf, Kurt Friese
Peatlands can be a potential source of dissolved organic matter (DOM) in fresh water catchment areas. The quantity and quality of DOM can differ between pristine, degraded and rewetted peatlands. Due to the large scale and continuing losses of peatlands, their conservation and restoration has been increasingly emphasized. Mostly rewetting measures are required to improve the hydrology of damaged peatlands, which is a precondition for the resettlement of peat-forming plant species. Thus, in term of DOM, there is a special need to understand how rewetting measures affect DOM characteristics and concentrations...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213824/an-approach-to-the-research-on-ion-and-water-properties-in-the-interphase-between-the-plasma-membrane-and-bulk-extracellular-solution
#10
REVIEW
Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku
In vivo, cells are immersed in an extracellular solution that contains a variety of bioactive substances including ions and water. Classical electrophysiological analyses of epithelial cells in the stomach and small intestine have revealed that within a distance of several hundred micrometers above their apical plasma membrane, lies an extracellular layer that shows ion concentration gradients undetectable in the bulk phase. This "unstirred layer", which contains stagnant solutes, may also exist between the bulk extracellular solution and membranes of other cells in an organism and may show different properties...
February 17, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28213029/antifungal-effect-of-volatile-organic-compounds-produced-by-bacillus-amyloliquefaciens-cpa-8-against-fruit-pathogen-decays-of-cherry
#11
A Gotor-Vila, N Teixidó, A Di Francesco, J Usall, L Ugolini, R Torres, M Mari
The present work focuses on the antifungal effect of volatile organic compounds (VOCs) produced by Bacillus amyloliquefaciens CPA-8 against Monilinia laxa, M. fructicola and Botrytis cinera, three postharvest fruit pathogens of sweet cherry fruit. VOCs were evaluated with a double petri dish assay against mycelial and colony growth of target pathogens. For this purpose, CPA-8 was grown on different media and cultured for 24 and 48 h at 30 °C before assays. Data showed that mycelial growth inhibition was higher when CPA-8 was grown on Tryptone Soya Agar (TSA) while no differences were generally observed when CPA-8 was cultured for either, 24 and 48 h...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28212418/experimental-evidence-of-formation-of-transparent-exopolymer-particles-tep-and-poc-export-provoked-by-dust-addition-under-current-and-high-pco2-conditions
#12
Justine Louis, Maria Luiza Pedrotti, Frédéric Gazeau, Cécile Guieu
The evolution of organic carbon export to the deep ocean, under anthropogenic forcing such as ocean warming and acidification, needs to be investigated in order to evaluate potential positive or negative feedbacks on atmospheric CO2 concentrations, and therefore on climate. As such, modifications of aggregation processes driven by transparent exopolymer particles (TEP) formation have the potential to affect carbon export. The objectives of this study were to experimentally assess the dynamics of organic matter, after the simulation of a Saharan dust deposition event, through the measurement over one week of TEP abundance and size, and to evaluate the effects of ocean acidification on TEP formation and carbon export following a dust deposition event...
2017: PloS One
https://www.readbyqxmd.com/read/28212399/instrument-design-and-protocol-for-the-study-of-light-controlled-processes-in-aquatic-organisms-and-its-application-to-examine-the-effect-of-infrared-light-on-zebrafish
#13
Marcus P S Dekens, Nicholas S Foulkes, Kristin Tessmar-Raible
The acquisition of reliable data strongly depends on experimental design. When studying the effects of light on processes such as behaviour and physiology it is crucial to maintain all environmental conditions constant apart from the one under study. Furthermore, the precise values of the environmental factors applied during the experiment should be known. Although seemingly obvious, these conditions are often not met when the effects of light are being studied. Here, we document and discuss the wavelengths and light intensities of natural and artificial light sources...
2017: PloS One
https://www.readbyqxmd.com/read/28211900/amyloid-%C3%AE-oligomers-interact-with-neurexin-and-diminish-neurexin-mediated-excitatory-presynaptic-organization
#14
Yusuke Naito, Yuko Tanabe, Alfred Kihoon Lee, Edith Hamel, Hideto Takahashi
Alzheimer's disease (AD) is characterized by excessive production and deposition of amyloid-beta (Aβ) proteins as well as synapse dysfunction and loss. While soluble Aβ oligomers (AβOs) have deleterious effects on synapse function and reduce synapse number, the underlying molecular mechanisms are not well understood. Here we screened synaptic organizer proteins for cell-surface interaction with AβOs and identified a novel interaction between neurexins (NRXs) and AβOs. AβOs bind to NRXs via the N-terminal histidine-rich domain (HRD) of β-NRX1/2/3 and alternatively-spliced inserts at splicing site 4 of NRX1/2...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211791/motor-control-of-drosophila-feeding-behavior
#15
Olivia Schwarz, Ali Asgar Bohra, Xinyu Liu, Heinrich Reichert, Krishnaswamy VijayRaghavan, Jan Pielage
The precise coordination of body parts is essential for survival and behavior of higher organisms. While progress has been made towards the identification of central mechanisms coordinating limb movement, only limited knowledge exists regarding the generation and execution of sequential motor action patterns at the level of individual motoneurons. Here we use Drosophila proboscis extension as a model system for a reaching-like behavior. We first provide a neuroanatomical description of the motoneurons and muscles contributing to proboscis motion...
February 17, 2017: ELife
https://www.readbyqxmd.com/read/28208235/warmer-night-time-temperature-promotes-microbial-heterotrophic-activity-and-modifies-stream-sediment-community
#16
Anna Freixa, Vicenç Acuña, Maria Casellas, Stoyana Pecheva, Anna M Romaní
Diel temperature patterns are changing because of global warming, with higher temperatures being predicted to be more pronounced at night. Biological reactions are temperature dependent, with some occurring only during the daylight hours (e.g., light photosynthesis) and other during the entire day (e.g., respiration). Consequently, we expect the modification of daily temperature cycles to alter microbial biological reactions in stream sediments. Here, we aimed to study the effect of warming and changes of the diel temperature patterns on stream sediment biofilm functions tied to organic carbon decomposition, as well as on biofilm meiofaunal community structure...
February 16, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28208093/oxidative-transformation-of-artificial-sweetener-acesulfame-by-permanganate-reaction-kinetics-transformation-products-and-pathways-and-ecotoxicity
#17
Kai Yin, Fei Li, Ying Wang, Qunying He, Yongxiu Deng, Shuo Chen, Chengbin Liu
Acesulfame has attracted much attention due to its wide application, environmental persistence and potential safety risk of transformation products (TPs). Little information is known on acesulfame transformation in the presence of oxidants/disinfectants. The acesulfame oxidation by permanganate (Mn(VII)) in water under environmentally relevant conditions was systematically evaluated. The pH of water showed negligible influence in acesulfame oxidation. Inorganic ligand (pyrophosphate) exhibited insignificant effect whereas organic ligands (oxalate, ethylene diamine tetraacetic acid, and humic acid) exerted obvious suppression on acesulfame oxidation...
February 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28206752/columnar-self-assemblies-of-triarylamines-as-scaffolds-for-artificial-biomimetic-channels-for-ion-and-for-water-transport
#18
Susanne Schneider, Erol-Dan Licsandru, Istvan Kocsis, Arnaud Gilles, Florina Dumitru, Emilie Moulin, Junjun Tan, Jean-Marie Lehn, Nicolas Giuseppone, Mihail Barboiu
Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating the crown ethers work as single channels for the selective transport of K+ or Rb+. The X-ray crystallographic structures confirm the mutual columnar self-assembly of triarylamines and crown-ethers. The dimensional fit of K+ cations within the 18-crown-6, leads to a partial dehydration and to the formation of alternating K+ cation-water wires within the channel...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28199209/photosystem-ii-and-terminal-respiratory-oxidases-molecular-machines-operating-in-opposite-directions
#19
Sergey A Siletsky, Vitaliy B Borisov, Mahir D Mamedov
In the thylakoid membrane of green plants, cyanobacteria and algae, photosystem II (PSII) uses light energy to split water and generate molecular oxygen. In the opposite process of the biochemical transformation of dioxygen, in heterotrophs, the terminal respiratory oxidases (TRO) are at the end of the respiratory chain in mitochondria and in plasma membrane of many aerobic bacteria reducing dioxygen back to water. Despite the different sources of free energy (light or oxidation of the substrates), energy conversion by these enzymes is based on the spatial organization of enzymatic reactions in which the conversion of water to dioxygen (and vice versa) involves the transfer of protons and electrons in opposite directions across the membrane, which is accompanied by generation of proton-motive force...
March 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28198663/unhindered-copper-uptake-by-glutaraldehyde-polyethyleneimine-coatings-in-an-artificial-seawater-model-system-with-adsorbed-swollen-polysaccharides-and-competing-ligand-edta
#20
Simarpreet Kaur, Ivan M Kempson, Johan B Lindén, Mikael Larsson, Magnus Nydén
Shortly after a surface is submerged in the sea, a conditioning film is generally formed by adsorption of organic molecules, such as polysaccharides. This could affect transport of molecules and ions between the seawater and the surface. An artificial seawater model system was developed to understand how adsorbed polysaccharides impact copper binding by glutaraldehyde-crosslinked polyethyleneimine coatings. Coating performance was also determined when competed against copper-chelating EDTA. Polysaccharide adsorption and copper binding and distribution were investigated using advanced analytical techniques, including depth-resolved time-of-flight secondary ion mass spectroscopy, grazing incidence X-ray absorption near-edge spectroscopy, quartz crystal microbalance with dissipation monitoring and X-ray photoelectron spectroscopy...
February 2017: Biofouling
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