keyword
MENU ▼
Read by QxMD icon Read
search

artificial organ

keyword
https://www.readbyqxmd.com/read/28719441/fourteen-day-in-vivo-testing-of-a-compliant-thoracic-artificial-lung
#1
David J Skoog, Joshua R Pohlmann, David S Demos, Christopher N Scipione, Amit Iyengar, Rebecca E Schewe, Ahmed B Suhaib, Kelly L Koch, Keith E Cook
The compliant thoracic artificial lung (cTAL) has been studied in acute in vivo and in vitro experiments. The cTAL's long-term function and potential use as a bridge to lung transplantation are assessed presently. The cTAL without anticoagulant coatings was attached to sheep (n = 5) via the pulmonary artery and left atrium for 14 days. Systemic heparin anticoagulation was used. Compliant thoracic artificial lung resistance, cTAL gas exchange, hematologic parameters, and organ function were recorded. Two sheep were euthanized for nondevice-related issues...
July 14, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28719236/applying-an-artificial-neural-network-model-for-developing-a-severity-score-for-patients-with-hereditary-amyloid-polyneuropathy
#2
Shenia Novis, Felipe Machado, Victor B Costa, Debora Foguel, Marcia W Cruz, José Manoel de Seixas
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validated. This work proposes the implementation of an artificial neural network (ANN) in order to develop a severity scale for monitoring the disease progression in FAP patients. In order to achieve this goal, relevant symptoms and laboratory findings were collected from 98 Brazilian patients included in THAOS - the Transthyretin Amyloidosis Outcomes Survey...
July 18, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28714313/artificial-metalloenzymes-reaction-scope-and-optimization-strategies
#3
Fabian Schwizer, Yasunori Okamoto, Tillmann Heinisch, Yifan Gu, Michela M Pellizzoni, Vincent Lebrun, Raphael Reuter, Valentin Köhler, Jared C Lewis, Thomas R Ward
The incorporation of a synthetic, catalytically competent metallocofactor into a protein scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late 1970's. Progress in the ensuing years was limited by the tools available for both organometallic synthesis and protein engineering. Advances in both of these areas, combined with increased appreciation of the potential benefits of combining attractive features of both homogeneous catalysis and enzymatic catalysis, led to a resurgence of interest in ArMs starting in the early 2000's...
July 17, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28713249/crispr-cas9-mediated-zebrafish-knock-in-as-a-novel-strategy-to-study-midbrain-hindbrain-boundary-development
#4
Gokul Kesavan, Avinash Chekuru, Anja Machate, Michael Brand
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either mesencephalic (midbrain) or metencephalic (hindbrain) cells by secreting signaling molecules like Wnt1 and Fgf8. The zebrafish is an excellent vertebrate model for studying MHB development due to the ease of gene manipulation and the possibility of following cellular dynamics and morphogenetic processes using live imaging. Currently, only very few reporter and/or Cre-driver lines are available to study gene expression at the MHB, hampering the understanding of MHB development, and traditional transgenic technologies using promoter/enhancer fragments or bacterial artificial chromosome (BAC)-mediated transgenesis often do not faithfully recapitulate endogenous expression patterns...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28707626/performance-of-neural-networks-for-localizing-moving-objects-with-an-artificial-lateral-line
#5
Luuk H Boulogne, Ben J Wolf, Marco A Wiering, Sietse M van Netten
Fish are able to sense water flow velocities relative to their body with their mechanoreceptive lateral line organ. This organ consists of an array of flow detectors distributed along the fish body. Using the excitation of these individual detectors, fish can determine the location of nearby moving objects. Inspired by this sensory modality, it is shown here how neural networks can be used to extract an object's location from simulated excitation patterns, such as can be measured along arrays of stationary artificial flow velocity sensors...
July 14, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28706739/emulation-with-organic-memristive-devices-of-impairment-of-ltp-mechanism-in-neurodegenerative-disease-pathology
#6
Silvia Battistoni, Victor Erokhin, Salvatore Iannotta
We explore and demonstrate the extension of the synapse-mimicking properties of memristive devices to a dysfunctional synapse as it occurs in the Alzheimer's disease (AD) pathology. The ability of memristive devices to reproduce synapse properties such as LTP, LTD, and STDP has been already widely demonstrated, and moreover, they were used for developing artificial neuron networks (perceptrons) able to simulate the information transmission in a cell network. However, a major progress would be to extend the common sense of neuromorphic device even to the case of dysfunction of natural synapses...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28706306/ligand-induced-type-ii-interleukin-4-receptor-dimers-are-sustained-by-rapid-re-association-within-plasma-membrane-microcompartments
#7
David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K Christopher Garcia, Thomas D Müller, Jacob Piehler
The spatiotemporal organization of cytokine receptors in the plasma membrane is still debated with models ranging from ligand-independent receptor pre-dimerization to ligand-induced receptor dimerization occurring only after receptor uptake into endosomes. Here, we explore the molecular and cellular determinants governing the assembly of the type II interleukin-4 receptor, taking advantage of various agonists binding the receptor subunits with different affinities and rate constants. Quantitative kinetic studies using artificial membranes confirm that receptor dimerization is governed by the two-dimensional ligand-receptor interactions and identify a critical role of the transmembrane domain in receptor dimerization...
July 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28703280/the-oregonheart-total-artificial-heart-design-and-performance-on-a-mock-circulatory-loop
#8
Jeremy Glynn, Howard Song, Bryan Hull, Stanley Withers, Jill Gelow, James Mudd, Albert Starr, Richard Wampler
Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles between two positions to provide pulsatile, alternating blood flow to the systemic and pulmonary circulations without artificial valves. Flow rates and pressures generated by the TAH are controlled by adjusting rotor speed, cycle frequency, and the proportion of each cycle spent pumping to either circulation...
July 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28700652/anomalous-diffusion-and-q-weibull-velocity-distributions-in-epithelial-cell-migration
#9
Tatiane Souza Vilela Podestá, Tiago Venzel Rosembach, Anésia Aparecida Dos Santos, Marcelo Lobato Martins
In multicellular organisms, cell motility is central in all morphogenetic processes, tissue maintenance, wound healing and immune surveillance. Hence, the control of cell motion is a major demand in the creation of artificial tissues and organs. Here, cell migration assays on plastic 2D surfaces involving normal (MDCK) and tumoral (B16F10) epithelial cell lines were performed varying the initial density of plated cells. Through time-lapse microscopy quantities such as speed distributions, velocity autocorrelations and spatial correlations, as well as the scaling of mean-squared displacements were determined...
2017: PloS One
https://www.readbyqxmd.com/read/28698790/sequential-stamen-maturation-and-movement-in-a-protandrous-herb-mechanisms-increasing-pollination-efficiency-and-reducing-sexual-interference
#10
Chang-Long Xiao, Hui Deng, Gan-Ju Xiang, Kadiori Edwin Luguba, You-Hao Guo, Chun-Feng Yang
Successive stamen movement directly controls pollen presentation schedules through sequential stamen maturation and changes the extent of herkogamy by altering the positions of sexual organs. However, the implications of such movements in terms of pollination are not well understood. Pollen presentation theory predicts that staggered pollen presentation should be favoured when plants are subject to diminishing returns on pollen transfer. Herkogamy on the other hand, has been interpreted as an adaptive trait that reduces sexual interference in hermaphrodite flowers...
May 2017: AoB Plants
https://www.readbyqxmd.com/read/28698018/carrying-pieces-of-information-in-organocatalytic-bytes-semiopoiesis-a-new-theory-of-life-and-its-origins
#11
Wanderley Dantas Dos Santos
Living beings have been classically described as autopoietic machines: chemical systems, which maintain a reproducible steady state by producing their components and boundaries. On the other hand, very simple autopoietic micelles have been produced in laboratory. They consist in micelles able to catalyse the production of their own surfactants. However is very clear that these autopoietic systems are unable to evolve. In this way, these autopoietic micelles cannot be associated to living organisms, which are always linked by evolutionary relationships...
July 8, 2017: Bio Systems
https://www.readbyqxmd.com/read/28697965/beyond-organoids-in-vitro-vasculogenesis-and-angiogenesis-using-cells-from-mammals-and-zebrafish
#12
REVIEW
Muhammad Ibrahim, Michael K Richardson
The ability to culture complex organs is currently an important goal in biomedical research. It is possible to grow organoids (3D organ-like structures) in vitro; however, a major limitation of organoids, and other 3D culture systems, is the lack of a vascular network. Protocols developed for establishing in vitro vascular networks typically use human or rodent cells. A major technical challenge is the culture of functional (perfused) networks. In this rapidly advancing field, some microfluidic devices are now getting close to the goal of an artificially perfused vascular network...
July 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28696374/dissolution-induced-nanowire-synthesis-on-hot-dip-galvanized-surface-in-supercritical-carbon-dioxide
#13
Aaretti Kaleva, Ville Saarimaa, Saara Heinonen, Juha-Pekka Nikkanen, Antti Markkula, Pasi Väisänen, Erkki Levänen
In this study, we demonstrate a rapid treatment method for producing a needle-like nanowire structure on a hot-dip galvanized sheet at a temperature of 50 °C. The processing method involved only supercritical carbon dioxide and water to induce a reaction on the zinc surface, which resulted in growth of zinc hydroxycarbonate nanowires into flower-like shapes. This artificial patina nanostructure predicts high surface area and offers interesting opportunities for its use in industrial high-end applications. The nanowires can significantly improve paint adhesion and promote electrochemical stability for organic coatings, or be converted to ZnO nanostructures by calcining to be used in various semiconductor applications...
July 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28696353/array-of-chemosensitive-resistors-with-composites-of-gas-chromatography-gc-materials-and-carbon-black-for-detection-and-recognition-of-vocs-a-basic-study
#14
Bartosz Wyszynski, Rui Yatabe, Atsuo Nakao, Masaya Nakatani, Akio Oki, Hiroaki Oka, Kiyoshi Toko
Mimicking the biological olfaction, large odor-sensor arrays can be used to acquire a broad range of chemical information, with a potentially high degree of redundancy, to allow for enhanced control over the sensitivity and selectivity of artificial olfaction systems. The arrays should consist of the largest possible number of individual sensing elements while being miniaturized. Chemosensitive resistors are one of the sensing platforms that have a potential to satisfy these two conditions. In this work we test viability of fabricating a 16-element chemosensitive resistor array for detection and recognition of volatile organic compounds (VOCs)...
July 11, 2017: Sensors
https://www.readbyqxmd.com/read/28695494/identifying-trace-metal-distribution-and-occurrence-in-sediments-inundated-soils-and-non-flooded-soils-of-a-reservoir-catchment-using-self-organizing-maps-an-artificial-neural-network-method
#15
Fangyan Cheng, Shiliang Liu, Yijie Yin, Yueqiu Zhang, Qinghe Zhao, Shikui Dong
The Lancang-Mekong River is a trans-boundary river which provides a livelihood for over 60 million people in Southeast Asia. Its environmental security is vital to both local and regional inhabitants. Efforts have been undertaken to identify controlling factors of the distribution of trace metals in sediments and soils of the Manwan Reservoir catchment in the Lancang-Mekong River basin. The physicochemical attributes of 63 spatially distributed soil and sediment samples, along with land-use, flooding, topographic, and location characteristics, were analyzed using the Self-Organizing Map (SOM) methodology...
July 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28695198/neat-monolayer-tiling-of-molecularly-thin-two-dimensional-materials-in-1-min
#16
Kazuaki Matsuba, Chengxiang Wang, Kazuko Saruwatari, Yusuke Uesusuki, Kosho Akatsuka, Minoru Osada, Yasuo Ebina, Renzhi Ma, Takayoshi Sasaki
Controlled arrangement of molecularly thin two-dimensional (2D) materials on a substrate, particularly into precisely organized mono- and multilayer structures, is a key to design a nanodevice using their unique and enhanced physical properties. Several techniques such as mechanical transfer process and Langmuir-Blodgett deposition have been applied for this purpose, but they have severe restrictions for large-scale practical applications, for example, limited processable area and long fabrication time, requiring skilled multistep operations...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28695195/self-organization-of-maze-like-structures-via-guided-wrinkling
#17
Hyung Jong Bae, Sangwook Bae, Jinsik Yoon, Cheolheon Park, Kibeom Kim, Sunghoon Kwon, Wook Park
Sophisticated three-dimensional (3D) structures found in nature are self-organized by bottom-up natural processes. To artificially construct these complex systems, various bottom-up fabrication methods, designed to transform 2D structures into 3D structures, have been developed as alternatives to conventional top-down lithography processes. We present a different self-organization approach, where we construct microstructures with periodic and ordered, but with random architecture, like mazes. For this purpose, we transformed planar surfaces using wrinkling to directly use randomly generated ridges as maze walls...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28694844/a-synthetic-biology-approach-to-engineering-living-photovoltaics
#18
N Schuergers, C Werlang, C M Ajo-Franklin, A A Boghossian
The ability to electronically interface living cells with electron accepting scaffolds is crucial for the development of next-generation biophotovoltaic technologies. Although recent studies have focused on engineering synthetic interfaces that can maximize electronic communication between the cell and scaffold, the efficiency of such devices is limited by the low conductivity of the cell membrane. This review provides a materials science perspective on applying a complementary, synthetic biology approach to engineering membrane-electrode interfaces...
May 1, 2017: Energy & Environmental Science
https://www.readbyqxmd.com/read/28694548/exposure-of-few-layer-graphene-to-limnodrilus-hoffmeisteri-modifies-the-graphene-and-changes-its-bioaccumulation-by-other-organisms
#19
Liang Mao, Chuanling Liu, Kun Lu, Yu Su, Cheng Gu, Qingguo Huang, Elijah J Petersen
While graphene has substantial commercial promise, numerous aspects regarding its ecological effects such as its potential for bioaccumulation are not well known. (14)C-labeled few layer graphene (FLG) was dispersed in artificial freshwater and uptake of FLG by Limnodrilus hoffmeisteri, an oligochaete, was assessed. After exposure for 36 h to a 1 mg/L FLG suspension, the FLG body burden in the organism was nearly 60 ng/mg (on a dry mass basis). Multiple characterization results confirmed that the proteins secreted by the organisms during the exposure period coated the FLG, thus increasing its stability and decreasing its size in suspension...
November 2016: Carbon
https://www.readbyqxmd.com/read/28693728/electrochemical-detection-of-cardiac-biomarker-myoglobin-using-polyphenol-as-imprinted-polymer-receptor
#20
J A Ribeiro, C M Pereira, A F Silva, M Goreti F Sales
An electrochemical biosensor was developed by merging the features of Molecular Imprinting technique and Screen-Printed Electrode (SPE) for the simple and fast screening of cardiac biomarker myoglobin (Myo) in point-of-care (POC). The MIP artificial receptor for Myo was prepared by electrooxidative polymerization of phenol (Ph) on a AuSPE in the presence of Myo as template molecule. The choice of the most effective protein extraction procedure from the various extraction methods tested (mildly acidic/basic solutions, pure/mixed organic solvents, solutions containing surfactants and enzymatic digestion methods), and the optimization of the thickness of the polymer film was carefully undertaken in order to improve binding characteristics of Myo to the imprinted polymer receptor and increase the sensitivity of the MIP biosensor...
August 15, 2017: Analytica Chimica Acta
keyword
keyword
50058
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"