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Diagnosis of hepatitis c

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https://www.readbyqxmd.com/read/28089429/diagnosis-and-quantification-of-fibrosis-steatosis-and-hepatic-siderosis-through-multiparametric-magnetic-resonance-imaging
#1
M Stoopen-Rometti, E R Encinas-Escobar, C R Ramirez-Carmona, E Wolpert-Barraza, E Kimura-Hayama, L A Sosa-Lozano, R Favila, Y Kimura-Fujikami, J A Saavedra-Abril, A Loaeza-Del Castillo
BACKGROUND: The presence of liver fibrosis is the common denominator in numerous chronic liver diseases that can progress to fibrosis and hepatocellular carcinoma. Most important, with respect to frequency, are viral hepatitis and non-alcoholic fatty liver disease, the prevalence of which is increasing in epidemic proportions. Liver biopsy, albeit imperfect, continues to be the criterion standard, but in many clinical situations tends to be replaced with noninvasive imaging methods. OBJECTIVES: The aim of the present article was to describe our imaging department experience with magnetic resonance elastography and to analyze and discuss recently published results in gastroenterology, hepatology, and radiology from other authors in the literature, complemented with a PubMed search covering the last 10 years...
January 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28087291/primary-care-perspectives-on-hepatitis-c-virus-screening-diagnosis-and-linking-patients-to-appropriate-care
#2
Edward Lebovics, Richard Torres, Lucinda K Porter
Enormous progress has been made in recent years toward effectively treating and curing patients with chronic hepatitis C (CHC). However, at least half of the possible 7 million individuals infected with hepatitis C virus (HCV) in the US remain undiagnosed. The formidable task of increasing the number of patients diagnosed, and subsequently linked to appropriate care has fallen to primary care clinicians, who are mandated by some US States to offer screening to individuals born between 1945 and 1965 (the Baby Boomer Generation)...
January 10, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28079668/noninvasive-assessment-of-portal-hypertension-and-detection-of-esophageal-varices-in-cirrhosis-state-of-the-art
#3
Ana C de Oliveira
Portal hypertension (PHT) is a major consequence of any chronic liver disease and it is the main cause of complications in patients with cirrhosis. Measurement of hepatic vein pressure gradient is considered the gold standard for PHT assessment, together with its diagnosis and prognosis relevance. Even though hepatic vein pressure gradient measurement is a safe procedure, it is still considered an invasive technique and not widely available. There is thus a need for noninvasive methods that can predict the progression of PHT as well as the presence and the risk of complications related to esophageal varices...
January 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28074540/complications-of-percutaneous-liver-biopsy-with-klatskin-needles-a-36-year-single-centre-experience
#4
V Takyar, O Etzion, T Heller, D E Kleiner, Y Rotman, M G Ghany, N Fryzek, V H Williams, E Rivera, S Auh, T J Liang, J H Hoofnagle, C Koh
BACKGROUND: Liver biopsy is the gold standard in evaluating liver diseases but is susceptible to complications. Safety data on aspiration needle biopsies remain limited. AIM: To evaluate the safety of percutaneous liver biopsy performed with Klatskin needle. METHODS: Clinical and biochemical data were retrospectively retrieved from sequential subjects who underwent liver biopsy with Klatskin needle from 1978 to 2015. Subjects with complications underwent thorough chart reviews for hospital course...
January 10, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28072961/-a-case-report-of-childhood-farber-s-disease-and-literature-review
#5
X H Bao, J M Tian, T Y Ji, X Z Chang
Objective: To explore the clinical features, diagnosis, treatment and the prognosis of Farber disease by case report and literature review. Method: The clinical information of a case with farber's disease diagnosed in October 2015 at Peking University First Hospital was collected and analyzed, including clinical manifestation, electrophysiology, magnetic resonance imaging, pathology, treatments and prognosis.ASAH1 gene mutational analysis was conducted in the patient and her parents.By using "Farber's disease, ASAH1" as keywords, literature was searched from Pubmed, CHKD and HGMD database from January 1951 to January 2016...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28068185/prevalence-of-antibodies-against-coxiella-burnetii-in-korean-native-cattle-dairy-cattle-and-dogs-in-south-korea
#6
Kwang-Soo Lyoo, Doo Kim, Hyung Gwan Jang, Seung-Joon Lee, Mi Yeoun Park, Tae-Wook Hahn
Coxiella burnetii is a zoonotic agent and causes coxiellosis, which is a cause of reproductive failure in a range of animal species, including abortion and stillbirth and Q fever, which is most often characterized by an acute flu-like illness, mild pneumonia, and/or hepatitis in humans. While livestock are well recognized worldwide as a source of infection, the zoonotic risk of C. burnetii infection in companion animals such as dogs may be overlooked. For serological diagnosis, indirect immunofluorescent assay (IFA) and enzyme-linked immunosorbent assay (ELISA) are generally considered good methods for prevalence surveys of coxiellosis...
January 9, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28066793/characterizing-failure-to-establish-hepatitis-c-care-of-baby-boomers-diagnosed-in-the-emergency-department
#7
Ricardo A Franco, E Turner Overton, Ashutosh R Tamhane, Jordan M Forsythe, Joel B Rodgers, Julie K Schexnayder, Deanne Guthrie, Suneetha Thogaripally, Anne Zinski, Michael S Saag, Michael J Mugavero, Henry E Wang, James W Galbraith
BACKGROUND: Emergency departments (EDs) are high-yield sites for hepatitis C virus (HCV) screening, but data regarding linkage to care (LTC) determinants are limited. METHODS: Between September 2013 and June 2014, 4371 baby boomers unaware of their HCV status presented to the University of Alabama at Birmingham ED and underwent opt-out screening. A linkage coordinator facilitated referrals for positive cases. Demographic data, International Classification of Diseases, Ninth Revision codes, and clinic visits were collected, and patients were (retrospectively) followed up until February 2015...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28060834/estimating-the-cost-effectiveness-of-one-time-screening-and-treatment-for-hepatitis-c-in-korea
#8
Do Young Kim, Kwang-Hyub Han, Byungyool Jun, Tae Hyun Kim, Sohee Park, Thomas Ward, Samantha Webster, Phil McEwan
BACKGROUND AND AIMS: This study aims to investigate the cost-effectiveness of a one-time hepatitis C virus (HCV) screening and treatment program in South Korea where hepatitis B virus (HBV) prevails, in people aged 40-70, compared to current practice (no screening). METHODS: A published Markov model was used in conjunction with a screening and treatment decision tree to model patient cohorts, aged 40-49, 50-59 and 60-69 years, distributed across chronic hepatitis C (CHC) and compensated cirrhosis (CC) health states (82...
2017: PloS One
https://www.readbyqxmd.com/read/28051834/interferon-%C3%AE-induced-protein-10-in-dengue-virus-infection
#9
P Fallahi, G Elia
Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Interferons (IFNs), and IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ-induced protein 10 (IP-10), CXCL9/MIG and CXCL11/I-TAC, and their common receptor chemokine (C-X-C motif) receptor (CXCR)3 are induced by DENV infection; however it has been shown that the latter two could not compensate for the absence of IP-10. This paper reviews studies about DENV and IP-10. Evidences show the importance of IP-10 induction during DENV infection, in macrophages, lymphocytes, hepatic cells, denritic cells, in skin and in the brain...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28050236/hepatitis-c-eradication-with-sofosbuvir-leads-to-significant-metabolic-changes
#10
Amilcar L Morales, Zachary Junga, Manish B Singla, Maria Sjogren, Dawn Torres
AIM: To assess the effect of sofosbuvir (SOF) based regimens on glycemic and lipid control. METHODS: This is a retrospective analysis of hepatitis C virus (HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir (LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C (HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study...
December 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/28040474/deep-sequencing-in-the-management-of-hepatitis-virus-infections
#11
REVIEW
Josep Quer, Francisco Rodríguez-Frias, Josep Gregori, David Tabernero, Maria Eugenia Soria, Damir García-Cehic, Maria Homs, Albert Bosch, Rosa María Pintó, Juan Ignacio Esteban, Esteban Domingo, Celia Perales
The hepatitis viruses represent a major public health problem worldwide. Procedures for characterization of the genomic composition of their populations, accurate diagnosis, identification of multiple infections, and information on inhibitor-escape mutants for treatment decisions are needed. Deep sequencing methodologies are extremely useful for these viruses since they replicate as complex and dynamic quasispecies swarms whose complexity and mutant composition are biologically relevant traits. Population complexity is a major challenge for disease prevention and control, but also an opportunity to distinguish among related but phenotypically distinct variants that might anticipate disease progression and treatment outcome...
December 28, 2016: Virus Research
https://www.readbyqxmd.com/read/28035496/the-role-of-current-and-historical-alcohol-use-in-hepatic-fibrosis-among-hiv-infected-individuals
#12
H Nina Kim, Heidi M Crane, Carla V Rodriguez, Stephen Van Rompaey, Kenneth H Mayer, Katerina Christopoulos, Sonia Napravnik, Geetanjali Chander, Heidi Hutton, Mary E McCaul, Edward R Cachay, Michael J Mugavero, Richard Moore, Elvin Geng, Joseph J Eron, Michael S Saag, Joseph O Merrill, Mari M Kitahata
We examined risk factors for advanced hepatic fibrosis [fibrosis-4 (FIB)-4 >3.25] including both current alcohol use and a diagnosis of alcohol use disorder among HIV-infected patients. Of the 12,849 patients in our study, 2133 (17%) reported current hazardous drinking by AUDIT-C, 2321 (18%) had a diagnosis of alcohol use disorder, 2376 (18%) were co-infected with chronic hepatitis C virus (HCV); 596 (5%) had high FIB-4 scores >3.25 as did 364 (15%) of HIV/HCV coinfected patients. In multivariable analysis, HCV (adjusted odds ratio (aOR) 6...
December 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/28032696/high-incidence-of-respiratory-involvement-in-a-cluster-of-brucella-suis-infected-workers-from-a-pork-processing-plant-in-argentina
#13
J C Wallach, J L García, P S Cardinali, A P Seijo, A G Benchetrit, S E Echazarreta, S L Garro, B Deodato, P C Baldi
Epidemiological and clinical aspects of Brucella suis infection in 17 workers from a pork processing plant in Argentina occurring between January 2014 and July 2015 are presented. All patients reported working 9 h daily without adequate personal protection garment. Blood cultures were positive for Brucella spp. in 14 of the 17 patients (82.3%). All isolates were identified as B. suis biovar 1. Although fever, sweats, asthenia, myalgia and hepatic involvement were the most frequent clinical manifestations, an unusually high incidence of respiratory involvement was found...
December 29, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28031848/spontaneous-hepatic-artery-dissection-a-rare-presentation-of-fibromuscular-dysplasia
#14
Kevin Y C Su, Melanie L Stanhope, Brendan P W Kaufman
Fibromuscular dysplasia (FMD) is a rare condition that causes structural compromise of the blood vessel presenting either as an incidental radiological finding, dissection or stenosis usually of the renal or craniocervical arteries. Seldom, patients present with spontaneous dissection in visceral arteries and there are few reports of hepatic involvement. This report outlines the case of a 43-year-old female who presented with severe right upper quadrant pain with a subsequent diagnosis of FMD manifesting as spontaneous hepatic artery dissection...
November 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28028821/sarcopenia-is-associated-with-severe-liver-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#15
S Petta, S Ciminnisi, V Di Marco, D Cabibi, C Cammà, A Licata, G Marchesini, A Craxì
BACKGROUND: Sarcopenia recognises insulin resistance and obesity as risk factors, and is frequently associated with cardiometabolic disorders, including non-alcoholic fatty liver disease (NAFLD). AIM: To test the prevalence of sarcopenia and its relation with the severity of fibrosis (main outcome) and the entire spectrum of liver histology in patients with NAFLD. METHODS: We considered 225 consecutive patients with histological diagnosis of NAFLD (Kleiner score)...
December 27, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28028370/incidence-of-hepatocellular-carcinoma-in-outpatients-with-cirrhosis-in-brazil-a-10-year-retrospective-cohort-study
#16
Marcelo Campos Appel-da-Silva, Suelen Aparecida da Silva Miozzo, Isabella de Azevedo Dossin, Cristiane Valle Tovo, Fernanda Branco, Angelo Alves de Mattos
AIM: To determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS: In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28024920/hepatic-adenomas-in-adolescents-and-young-women-with-endometriosis-treated-with-norethindrone-acetate
#17
P C Brady, S A Missmer, M R Laufer
BACKGROUND: Endometriosis-ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. First-line treatment includes progesterone-only (such as norethindrone acetate, NET-A) or combined estrogen/progestin oral contraceptive pills. Estrogen-containing contraceptives confer increased risk of hepatic adenomas, while the association with NET-A is very rarely reported. CASE: Three adolescents with Stage I-II endometriosis managed with NET-A (up to 15 mg/day for 28-78 months) were diagnosed with hepatic adenomas at ages 17-22 years...
December 23, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28013117/hepatocellular-carcinoma-is-the-most-common-indication-for-liver-transplantation-and-placement-on-the-waitlist-in-the-united-states
#18
Ju Dong Yang, Joseph J Larson, Kymberly D Watt, Alina M Allen, Russell H Wiesner, Gregory J Gores, Lewis R Roberts, Julie A Heimbach, Michael D Leise
BACKGROUND & AIMS: Management strategies for patients with hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) have changed, along with liver allocation policies based on model for end-stage liver disease (MELD) score. We investigated etiologic-specific trends in liver transplantation in the United States (US) during different time periods. METHODS: We performed a retrospective study, using the United Network for Organ Sharing/ Organ Procurement and Transplantation Network registry data to identify all adult patients registered for liver transplantation in the US from January 1, 2004 through December 31, 2015...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28009328/seroprevalence-and-diagnosis-of-hiv-hbv-hcv-and-syphilis-infections-among-blood-donors
#19
Tadesse Bekele Tafesse, Addis Adera Gebru, Semgne Gobalee, Gosaye Degu Bely, Molla Teferi Belew, Demelash Arso, Belay Ali Ebrahim, Getachew Mekonnon Shebeshi, Yonas Yimam
BACKGROUND: Blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. However, it is associated with certain risks which can lead to adverse consequences that may cause acute or delayed complications and bring the risk of transfusion-transmissible infections including HIV, Hepatitis B & C and Syphilis. So, there might be a fatal risk instead of life saving. This paper aims to provide a comprehensive and reliable tabulation of available data on seroprevalence and diagnosis of HIV, HBV, HCV and Syphilis infections among blood donors...
December 16, 2016: Human Antibodies
https://www.readbyqxmd.com/read/28007791/factors-associated-with-seminal-impairment-in-hiv-infected-men-under-antiretroviral-therapy
#20
A Jerónimo, M B Baza, I Río, M Vera, V Hernando, J Castilla, C Rodriguez, J Del Romero
STUDY QUESTION: How do semen parameters of HIV-infected men under antiretroviral treatment compare with WHO parameters of normal semen, and what factors are associated with any differences? SUMMARY ANSWER: Semen quality in most HIV-infected patients under antiretroviral treatment exceeds WHO limits, but the number falling below them is higher than would be expected in a healthy population. Exposure to efavirenz has a significant association with dysmotility. WHAT IS KNOWN ALREADY: Dysmotility is the most frequently described sperm alteration related to HIV infection, and it has recently been linked to treatment with non-nucleoside reverse transcriptase inhibitors, particularly to efavirenz...
December 21, 2016: Human Reproduction
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