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Diagnosis of hepatitis c

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https://www.readbyqxmd.com/read/29934358/factors-associated-with-anal-cancer-screening-follow-up-by-high-resolution-anoscopy
#1
Kaan Z Apaydin, Andrew Nguyen, Christina P C Borba, Derri L Shtasel, Sharon Ulery, Kenneth H Mayer, Alex S Keuroghlian
OBJECTIVES: High-resolution anoscopy (HRA) is a potential screening method for detection of anal cancer precursors. We evaluated factors associated with adherence to recommended HRA follow-up time intervals among men who have sex with men (MSM). METHODS: We employed a retrospective, observational cohort study with 155 MSM screened by HRA between 1 April 2011 and 31 March 2016 at a Federally Qualified Health Centre in Boston, Massachusetts. RESULTS: The sample was 80% white, with a median age of 48 (non-normal distribution, IQR 15)...
June 22, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29932040/estimating-the-prevalence-of-chronic-hepatitis-c-virus-infection-in-new-york-city-2015
#2
A Bocour, S K Greene, F Laraque, A Winters
Chronic hepatitis C virus (HCV) infection is the most common blood-borne infection in the USA. Estimating prevalence is critical for monitoring diagnosis, treatment, and cure and for allocating resources. Surveillance data reported to the New York City (NYC) Health Department, 2000-2015, were used to estimate HCV prevalence in NYC in 2015. The numbers who died, out-migrated or whose last RNA test was negative were removed from the count of people reported with HCV. A simulation model was used to remove estimates of people whose infection spontaneously cleared or was cured and to add an estimate of people unaware of infection...
June 22, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29929549/association-of-viral-hepatitis-and-bipolar-disorder-a-nationwide-population-based-study
#3
Lee-Won Chong, Chih-Chao Hsu, Chang-Yin Lee, Ruey-Hwang Chou, Cheng-Li Lin, Kuang-Hsi Chang, Yi-Chao Hsu
BACKGROUND: Bipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent mood fluctuations. This study aims to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for BD. METHODS: A total of 48,215 patients with newly diagnosed viral hepatitis from 2000 to 2010 were identified and frequency-matched with 192,860 people without hepatitis. Both groups were followed until diagnosis with BD, withdrawal from the national health insurance program, or the end of 2011...
June 22, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29928402/overexpression-of-%C3%AE-3-%C3%AE-3-and-%C3%AE-2-chains-of-laminin-332-is-associated-with-poor-prognosis-in-pancreatic-ductal-adenocarcinoma
#4
Jun Chen, Hao Zhang, Jiansheng Luo, Xiaokang Wu, Xueming Li, Xinyi Zhao, Dongkai Zhou, Shian Yu
Pancreatic ductal adenocarcinoma (PDA) is a worldwide health problem. Early diagnosis and assessment may enhance the quality of life and survival of patients. The present study investigated the potential correlations between the gene and protein expression of laminin-332 (LM-332 or laminin-5) and clinicopathological factors as well as evaluating its influence on the survival of patients with PDA. The expression of LM-332 subunit mRNAs in pancreatic carcinoma specimens from 37 patients was investigated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29923087/apparent-acetaminophen-toxicity-in-a-patient-with-transaldolase-deficiency
#5
Jasmine Lee-Barber, Taylor E English, Jacquelyn F Britton, Nara Sobreira, Jason Goldstein, David Valle, Hans Tomas Bjornsson
Transaldolase deficiency (MIM#: 606003) is a rare autosomal recessive defect in the pentose phosphate pathway. Affected individuals are at risk for progressive liver failure and hepatocarcinoma. In the transaldolase-deficient mouse model (Taldo1 -/- ), these hepatic complications are accentuated by oxidative stress related to acetaminophen administration. We report a 13-month-old transaldolase-deficient male who developed mild liver failure after receiving standard doses of acetaminophen during a febrile respiratory syncytial virus infection...
June 20, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29914381/a-qualitative-assessment-of-the-acceptability-of-hepatitis-c-remote-self-testing-and-self-sampling-amongst-people-who-use-drugs-in-london-uk
#6
Andy Guise, T Charles Witzel, Sema Mandal, Caroline Sabin, Tim Rhodes, Anthony Nardone, Magdalena Harris
BACKGROUND: Hepatitis C (HCV) diagnosis and care is a major challenge for people who use illicit drugs, and is characterised by low rates of testing and treatment engagement globally. New approaches to fostering engagement are needed. We explored the acceptability of remote forms of HCV testing including self-testing and self-sampling among people who use drugs in London, UK. METHODS: A qualitative rapid assessment was undertaken with people who use drugs and stakeholders in London, UK...
June 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29913531/volumetric-laser-endomicroscopy-in-the-biliary-and-pancreatic-ducts-a-feasibility-study-with-histological-correlation
#7
Juan E Corral, Omar Y Mousa, Murli Krishna, Iris J M Levink, Khela R Pursell, Mohammad Afsh, Paul T Kröner, Denise M Harnois, Herbert C Wolfsen, Michael B Wallace, Frank J Lukens
BACKGROUND:  Volumetric laser endomicroscopy (VLE) provides circumferential images 3 mm into the biliary and pancreatic ducts. We aimed to correlate VLE images with the normal and abnormal microstructure of these ducts. METHODS: Samples from patients undergoing hepatic or pancreatic resection were evaluated. VLE images were collected using a low-profile VLE catheter inserted manually into the biliary and pancreatic ducts ex vivo. Histological correlation was assessed by two unblinded investigators...
June 18, 2018: Endoscopy
https://www.readbyqxmd.com/read/29912761/inadequate-hepatocellular-carcinoma-screening-in-patients-with-nonalcoholic-steatohepatitis-cirrhosis
#8
Elizabeth Aby, Jennifer Phan, Emily Truong, Jonathan Grotts, Sammy Saab
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a common cause of liver disease which can progress to cirrhosis and hepatocellular carcinoma (HCC). American Association for the Study of Liver Diseases (AASLD) guidelines recommend abdominal ultrasound, with or without serum alpha-fetoprotein, every 6 months for HCC surveillance in cirrhotic patients. GOALS: Describe HCC surveillance rates in NASH cirrhosis compared with hepatitis C (HCV) cirrhosis and the impact of surveillance on tumor size, treatment, and mortality...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29910570/the-role-of-biochemical-variations-and-genotype-testing-in-determining-the-virological-response-of-patients-infected-with-hepatitis-c-virus
#9
Abid Shoukat, Mosin S Khan, Syed Mudassar, Zaffar Kawoosa, Altaf H Shah, Showkat Ali Zargar
Background: In hepatitis C virus (HCV), infection viral and IL28B genotype along with many clinical and biochemical factors can influence response rates to pegylated interferon plus ribavirin (Peg-IFN-a/R) therapy and progression to chronic hepatitis C (CHC). Aims: The present study was conducted to determine the effect of biochemical and risk factors on treatment outcome in CHC patients in relation to their viral and host genotype. Settings and Design: The present study was a prospective Pe- IFN efficacy study consisting of Peg-IFN-a/R therapy for 24-48 weeks including 250 HCV infected patients...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29910226/a-compound-heterozygous-mutation-of-lipase-maturation-factor-1-is-responsible-for-hypertriglyceridemia-of-a-patient
#10
Yihui Liu, Jiang Xu, Wanyun Tao, Rong Yu, Xinjiang Zhang
AIM: Dyslipidemia is the most common lipid metabolism disorder in humans, and its etiology remains elusive. Hypertriglyceridemia (HTG) is a type of dyslipidemia that contributes to atherosclerosis and coronary heart disease. Previous studies have demonstrated that mutations in lipoprotein lipase (LPL), apolipoprotein CII (APOC2), apolipoprotein AV (APOA5), glycosylphosphatidylinositol anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1), and glycerol-3 phosphate dehydrogenase 1 (GPD1) are responsible for HTG by using genomic microarrays and next-generation sequencing...
June 15, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29909701/prevalence-and-outcome-of-post-transfusion-hepatitis-c-acquired-at-different-ages-and-detected-in-look-back-screening
#11
Charlotta Millbourn, Afrodite Psaros Einberg, Gudrun Lindh, Ingegerd Hökeberg, Björn Fischler, Karin Lindahl
OBJECTIVES: The prevalence of hepatitis C virus (HCV) infection in Sweden is estimated to 0.5%. Before 1992, blood transfusion posed a risk of HCV transmission. The primary aim of this study was to estimate anti-HCV prevalence in Stockholm County among individuals receiving blood transfusions 1965-1991. The secondary aim was to study the effect of age at transfusion on the development of liver disease and treatment outcome. MATERIALS AND METHODS: This is a retrospective analysis of individuals found to be anti-HCV tested positive in Stockholm County during a national screening campaign in Sweden 2008-2010...
June 18, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909559/a-successful-treatment-for-hepatocellular-carcinoma-with-osler-rendu-weber-disease-using-radiofrequency-ablation-under-laparoscopy
#12
Yoshinari Takaoka, Naoki Morimoto, Kouichi Miura, Hiroaki Nomoto, Kozue Murayama, Takuya Hirosawa, Shunji Watanabe, Takeshi Fujieda, Mamiko Ttsukui, Hirotoshi Kawata, Toshiro Niki, Norio Isoda, Makoto Iijima, Hironori Yamamoto
Hepatocellular carcinoma (HCC) can be difficult to diagnose and treat in patients with Osler-Rendu-Weber disease due to vascular malformation and regenerative nodular hyperplasia. In addition, percutaneous liver puncture should be avoided for the diagnosis and treatment as the procedure carries a high risk of bleeding. We herein report the successful treatment of HCC in a patient with Osler-Rendu-Weber disease using radiofrequency ablation (RFA) under laparoscopy. A 71-year-old man with Osler-Rendu-Weber disease was admitted to our hospital for the treatment of HCC...
June 16, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29907367/a-pilot-study-on-the-implementation-of-reflex-testing-for-the-diagnosis-of-active-hepatitis-c-virus-infection
#13
Paz Casas, Daniel Navarro, Antonio Aguilera, Federico García
No abstract text is available yet for this article.
June 12, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29905754/a-novel-signal-on-photoelectrochemical-sensor-for-ultrasensitive-detection-of-alkaline-phosphatase-activity-based-on-a-tio-2-g-c-3-n-4-heterojunction
#14
Feng Xia Wang, Cui Ye, Shi Mo, Liu Li Liao, Xiao Fang Zhang, Yu Ling, Lu Lu, Hong Qun Luo, Nian Bing Li
The use of alkaline phosphatase (ALP) as a biomarker in some diseases including hepatitis, obstructive jaundice, osteoblastic bone cancer, and osteomalacia is important in clinical diagnosis. Furthermore, ALP activity detection is an essential hot topic in environmental monitoring, biomedical research, and other research fields. In this study, a novel "signal-on" photoelectrochemical (PEC) biosensor based on the ALP-catalyzed phosphorylation reaction was designed to sensitively detect ALP activity...
June 15, 2018: Analyst
https://www.readbyqxmd.com/read/29902988/additional-hepatic-166-ho-radioembolization-in-patients-with-neuroendocrine-tumours-treated-with-177-lu-dotatate-a-single-center-interventional-non-randomized-non-comparative-open-label-phase-ii-study-hepar-plus-trial
#15
Arthur J A T Braat, Dik J Kwekkeboom, Boen L R Kam, Jaap J M Teunissen, Wouter W de Herder, Koen M A Dreijerink, Rob van Rooij, Gerard C Krijger, Hugo W A M de Jong, Maurice A A J van den Bosch, Marnix G E H Lam
BACKGROUND: Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases. Treatment with peptide receptor radionuclide therapy (PRRT) shows a high objective response rate and long median survival after treatment. However, complete remission is almost never achieved. The liver is the most commonly affected organ in metastatic disease and is the most incriminating factor for patient survival...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29902392/a-surveillance-based-hepatitis-c-care-cascade-new-york-city-2017
#16
Miranda S Moore, Angelica Bocour, Fabienne Laraque, Ann Winters
OBJECTIVES: The care cascade, a method for tracking population-level progression from diagnosis to cure, is an important tool in addressing and monitoring the hepatitis C virus (HCV) epidemic. However, little agreement exists on appropriate care cascade steps or how best to measure them. The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) sought to construct a care cascade by using laboratory surveillance data with clinically relevant categories that can be readily updated over time...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29897132/association-between-proton-pump-inhibitors-and-the-risk-of-hepatocellular-carcinoma
#17
Y-H J Shao, T-S Chan, K Tsai, S-Y Wu
BACKGROUND: Proton pump inhibitor (PPI) use has been reported to be associated with liver damage and might possibly be carcinogenic. AIMS: We examined whether long-term PPI use increases the risk of hepatocellular carcinoma (HCC) in patients without viral hepatitis B or C. METHODS: We conducted a nested case-control study in a cohort of patients without viral hepatitis in Taiwan from 2000 to 2013. In total, 29 473 HCC cases and 294 508 matched controls were included...
June 13, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29895548/primary-carnitine-deficiency-in-a-57-year-old-patient-with-recurrent-exertional-rhabdomyolysis
#18
Andoni Echaniz-Laguna, Valérie Biancalana, Pauline Gaignard, Jean-Baptiste Chanson
Rhabdomyolysis is an emergency requiring rapid diagnosis and suitable aetiological treatment. We describe the case of a 57-year-old man with recurrent exertional rhabdomyolysis who was diagnosed with systemic primary carnitine deficiency (SPCD). Clinical examination was normal, creatine kinase levels were elevated, plasma free carnitine concentration was mildly decreased, muscle biopsy demonstrated lipid accumulation, carnitine uptake in cultured fibroblasts was decreased and genetic analysis identified a homozygous pathologic c...
June 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29893705/pattern-of-vascular-involvement-in-egyptian-patients-with-budd-chiari-syndrome-relation-to-etiology-and-impact-on-clinical-presentation
#19
Mohammad A Sakr, Sara M Abdelhakam, Hany M Dabbous, Ahmed S Abdelmoaty, Hend E Ebada, Wael M Al-Banna, Mohamed S Ghazy, Mohamed E Aboelmaaty, Ahmed K Eldorry
INTRODUCTION AND AIM: Budd-Chiari syndrome (BCS) is caused by hepatic venous outflow obstruction. This work aims to analyze the pattern of vascular involvement in Egyptian patients with BCS, demonstrates its relation to etiology and shows its impact on clinical presentation. MATERIAL AND METHODS: The current retrospective study was conducted at The Tropical Medicine Department, Ain Shams University on one hundred Egyptian patients with confirmed diagnosis of primary BCS who were presented to the Budd-Chiari Study Group (BCSG) from April 2014 to May 2016 by collecting clinical, laboratory and radiological data from their medical records...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29893698/association-between-serum-hemoglobin-levels-and-non-alcoholic-fatty-liver-disease-in-a-mexican-population
#20
Eva Juárez-Hernández, Norberto C Chávez-Tapia, Diana C Brizuela-Alcántara, Misael Uribe, Martha H Ramos-Ostos, Natalia Nuño-Lámbarri
INTRODUCTION AND AIM: Nonalcoholic fatty liver disease (NAFLD) is closely associated with overweight and obesity, becoming one of the most prevalent hepatic diseases nowadays. Circulating hemoglobin (Hb) concentration is significantly higher in people with NAFLD, compared to healthy patients. While liver biopsy remains the gold standard for NAFLD diagnosis, it is not the best technique due to adverse events that may occur. Therefore it is important to find less invasive and more sensitive markers...
July 2018: Annals of Hepatology
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