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https://www.readbyqxmd.com/read/29226638/reference-values-of-certain-serum-indicators-of-liver-fibrosis
#1
Blagovesta Pencheva, Rossen Mihajlov, Adelaida Ruseva, Rumyana Mitova, Kaloyan Petrov, Gergana Taneva, Jordan Genov
BACKGROUND: Liver fibrosis shows a continuously increasing trend worldwide, due to alcohol abuse, obesity, and, to a lesser extent, chronic hepatitis B and C. Biopsy is still considered the "gold standard" for diagnosis of liver fibrosis. However, it has a number of limitations, such as invasiveness, high cost, need for specialists to conduct and interpret biopsy results, risk of complications, inability to dynamically monitor the pathological process, low patient compliance, and uneven fibrosis distribution...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29225896/incidence-of-diabetes-mellitus-and-factors-associated-with-its-development-in-hiv-positive-patients-over-the-age-of-50
#2
Faizal Samad, Marianne Harris, Cathy M Puskas, Monica Ye, Jason Chia, Sarah Chacko, Gregory P Bondy, Viviane D Lima, Julio Sg Montaner, Silvia A Guillemi
Objective: We sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. Research design and methods: We analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29225673/update-on-hepatitis-c-and-implications-for-pregnancy
#3
REVIEW
Jeffrey J Post
Mother-to-child transmission of hepatitis C virus infection occurs in a significant minority of cases and the diagnosis, treatment and cure of hepatitis C virus infection with direct acting antivirals prior to pregnancy can eliminate this risk in almost all cases. Women with hepatitis C virus infection have increased risks of adverse events in pregnancy and poor perinatal outcomes for their children, although the contribution of hepatitis C virus per se is difficult to determine. Altering the mode of delivery does not reduce mother to child transmission of hepatitis C virus infection, although avoidance of fetal scalp electrodes and other potential high risk procedures is recommended during pregnancy and delivery...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29224513/infectious-necrotic-hepatitis-caused-by-clostridium-novyi-type-b-in-a-horse-case-report-and-review-of-the-literature
#4
Akinyi C Nyaoke, Mauricio A Navarro, Juliann Beingesser, Francisco A Uzal
A 14-y-old bay Quarter Horse gelding was presented with progressive neurologic signs, elevated rectal temperature, and icterus for 3 d prior to death. Postmortem examination revealed icterus, large amounts of serosanguineous fluid in the abdominal cavity, widespread petechiae and ecchymoses in several organs, and a large, pale, and well-demarcated focus of necrosis in the liver. Histologically, there was coagulative necrosis surrounded by a rim of inflammatory cells and large numbers of gram-positive rods, which were identified as Clostridium novyi by immunohistochemistry...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29222581/fractures-in-children-with-newly-diagnosed-hepatoblastoma
#5
Alexander J Towbin, Fernanda D C Braojos Braga, Bin Zhang, James I Geller, Greg M Tiao, Daniel J Podberesky
BACKGROUND: Hepatoblastoma is the most common primary hepatic malignancy in children. We have recently noticed an increased incidence of unsuspected fractures in children with newly diagnosed hepatoblastoma. This association has been suggested in the past, but the incidence and pathophysiology remain uncertain. OBJECTIVE: To define the incidence and imaging features of fractures in children with newly diagnosed hepatoblastoma. MATERIALS AND METHODS: We searched the oncology database and the radiology picture archiving and communication system of our large tertiary care children's hospital between January 2000 and August 2013 for all patients who presented to our institution with newly diagnosed hepatoblastoma...
December 8, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29221457/capillaria-hepatica-calodium-hepaticum-infection-in-a-horse-a-case-report
#6
Akihiro Ochi, Tatsuro Hifumi, Takanori Ueno, Yoshinari Katayama
BACKGROUND: Capillaria hepatica is a zoonotic parasite in humans and animals and has a worldwide distribution. However, infections in mammals apart from rodents, which are natural hosts of the parasite, have rarely been reported. This report describes the first known case of C. hepatica infection in a horse in Japan. CASE PRESENTATION: A 3-year-old filly without clinical signs was presented at a slaughterhouse in Japan. Gross examination revealed white to tan nodules 0...
December 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29220868/incidence-and-prevalence-of-hepatitis-b-in-patients-with-diabetes-mellitus-in-the-uk-a-population-based-cohort-study-using-the-uk-clinical-practice-research-datalink
#7
Germano L C Ferreira, Cinzia Marano, Laurence De Moerlooze, Adrienne Guignard, Yang Feng, Yassine El Hahi, Tjeerd van Staa
We assessed the incidence and prevalence of hepatitis B (Hep B) in patients with or without diabetes mellitus using the UK Clinical Practice Research Datalink. This was a retrospective, observational study of diabetic and non-diabetic cohorts aged 0-80 years using Clinical Practice Research Datalink (NCT02324218). Incidence rates (IR) for each cohort were calculated. Crude and adjusted (Poisson Regression) IR ratios (IRR) were estimated with 95% confidence intervals (CI) to compare the cohorts. Hep B prevalence stratified by age, and hospitalisation related to Hep B were also calculated...
December 8, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29217891/trimethoprim-sulfamethoxazole-induced-hepatotoxicity-in-a-renal-transplant-patient
#8
R Slim, N Asmar, C Yaghi, K Honein, R Sayegh, D Chelala
Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been made after a careful history taking, exclusion of competing etiologies and reversal of biochemical abnormalities after withdrawal of the antibiotic. TMP-SMX liver toxicity is well known but remains unpredictable and is rarely reported...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29214477/prevalence-of-occult-hepatitis-c-virus-among-hemodialysis-patients-in-tanta-university-hospitals-a-single-center-study
#9
Ghada Abdelmoemen, Samy Abdelkader Khodeir, Sabry Abou-Saif, Abdelrahman Kobtan, Sherief Abd-Elsalam
Occult hepatitis C virus infection (OCI) is a newly defined type of infection by the chronic hepatitis virus (HCV) distinguished by the existence of HCV RNA in liver tissue and/or peripheral blood mononuclear cells (PBMCs) in patients whose plasma are devoid of both positive serology and RNA. Patients on maintenance hemodialysis evince a higher HCV prevalence than the general population due to high nosocomial transmission by the dialysis units. We investigated the prevalence of occult HCV infection in patients attending our university hemodialysis centers for maintenance hemodialysis...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29211109/metagenomic-analysis-reveals-hepatitis-a-virus-in-suspected-yellow-fever-cases-in-brazil
#10
Liliane C Conteville, Ana Maria B de Filippis, Rita Maria R Nogueira, Marcos César L de Mendonça, Ana Carolina P Vicente
Using a metagenomic approach, we identified hepatitis A virus among cases of acute febrile illnesses that occurred in 2008-2012 in Brazil suspected as yellow fever. These findings reinforce the challenge facing routine clinical diagnosis in complex epidemiological scenarios.
January 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29209108/pathological-process-of-liver-sinusoidal-endothelial-cells-in-liver-diseases
#11
REVIEW
Yao Ni, Juan-Mei Li, Ming-Kun Liu, Ting-Ting Zhang, Dong-Ping Wang, Wen-Hui Zhou, Ling-Zi Hu, Wen-Liang Lv
Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix, which is closely related to liver sinusoidal endothelial cells (LSECs). Damaged LSECs can synthesize transforming growth factor-beta and platelet-derived growth factor, which activate hepatic stellate cells and facilitate the synthesis of extracellular matrix...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208877/significance-of-age-spleen-platelet-ratio-index-aspri-to-exclude-cirrhosis-in-patients-with-chronic-hepatitis-b
#12
F Ahmed, M A Mahtab, S Rahman, M F Karim, M Khan, T Akther, A H Manik, C R Debnath
Liver biopsy is an integral part of management of patients with Chronic Hepatitis B (CHB), which is helpful in confirming diagnosis, assessing grade of inflammation and stage of fibrosis and also in guiding treatment strategy. Although liver biopsy is relatively safe, morbidity occurs in 0.2-2% of patients. Hence various non-invasive markers, like AST-ALT Ratio (AAR), Age-Platelet Index (API), AST to Platelet Ratio Index (APRI), Fibroscan etc. have been developed worldwide to asses liver histology. Age-Spleen-Platelet Ratio Index (ASPRI) is new in this series...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208852/extremely-high-serum-ferritin-an-instrumental-marker-of-masquerading-adult-onset-still-s-disease-with-hemophagocytic-syndrome
#13
Shun Yamashita, Naoko E Furukawa, Tomoyo Matsunaga, Yuka Hirakawa, Masaki Tago, Shu-Ichi Yamashita
BACKGROUND Adult-onset Still's disease (AOSD) is a rare multi-systemic inflammatory disorder of unknown etiology characterized by spiking fever, characteristic rash, and arthritis. It often associates with high serum ferritin levels. CASE REPORT An 88-year-old woman had fever of over 39°C without response to extended-spectrum antibiotics for 6 days. She had non-specific erythema with infiltration on her trunk. She had leukocytosis with neutrophilia of 80%, mild hepatic dysfunction, normal level of rheumatoid factor and antinuclear antibody, thrombocytopenia, elevated d-dimer and soluble interleukin2 receptor, extremely high serum ferritin (78 662 ng/mL), and splenomegaly...
December 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29207078/characterizing-key-nucleotide-polymorphisms-of-hepatitis-c-virus-disease-associations-via-mass-spectrometric-genotyping
#14
Yuta Horiuchi, Jason Lin, Yui Shinojima, Kyoko Fujiwara, Mitsuhiko Moriyama, Hiroki Nagase
As more than 80% of hepatocellular carcinoma patients in Japan also suffer from hepatitis C virus infections some time in their medical history, identifying genetic aberrations associated to hepatitis C virulence in these individuals remains a high priority in the diagnosis and treatment of hepatocellular carcinoma. From the BioBank Japan Project, we acquired 480 subjects of hepatocellular carcinoma, chronic hepatitis and liver cirrhosis, and genotyped 131 clinically relevant host single nucleotide polymorphisms to survey the potential association between certain risk alleles and genes to a patient's predisposition to hepatitis C and liver cancer...
November 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29201802/hepatic-metastasis-from-colorectal-cancer
#15
Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva, Eduardo E Montalvo-Javé
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs...
July 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29201773/epidemiology-of-hepatitis-b-and-c-in-republic-of-indonesia
#16
REVIEW
David H Muljono
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections pose serious problems in terms of public health and clinical intervention in a country with approximately 250 million people, who live in more than 17,000 islands. Efforts to combat HBV and HCV have been made through the implementation of universal infant hepatitis B immunization, blood screening, and other health promotion actions, and building epidemiological data to develop intervention strategies. A nationwide study in 2013 revealed hepatitis B surface antigen (HBsAg) prevalence of 7...
January 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29200131/validation-of-an-algorithm-to-identify-infective-endocarditis-in-people-who-inject-drugs
#17
Laura J Ball, Adeel Sherazi, Dora Laczko, Kaveri Gupta, Sharon Koivu, Matthew A Weir, Tina Mele, Rommel Tirona, John K McCormick, Michael Silverman
INTRODUCTION: Infective endocarditis is associated with high morbidity and mortality. Currently, there is concern that the incidence of infective endocarditis associated with people who inject drugs (PWID) is increasing. However, it is difficult to monitor population-wide trends in PWID-associated infective endocarditis, as there is no International Statistical Classification of Diseases, 10th Revision (ICD-10) code for injection drug use. To address this barrier, we sought to develop a validated algorithm using ICD-10 discharge diagnosis codes...
December 1, 2017: Medical Care
https://www.readbyqxmd.com/read/29194861/trends-in-hepatocellular-carcinoma-incidence-and-survival-among-people-with-hepatitis-c-an-international-comparison
#18
Maryam Alavi, Naveed Z Janjua, Mei Chong, Jason Grebely, Esther J Aspinall, Hamish Innes, Heather Valerio, Behzad Hajarizadeh, Peter C Hayes, Mel Krajden, Janaki Amin, Matthew G Law, Jacob George, David J Goldberg, Sharon J Hutchinson, Gregory J Dore
This study evaluates trends in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) incidence and survival in three settings, prior to introduction of direct-acting antiviral (DAA) therapies. HCV notifications from British Columbia (BC), Canada, New South Wales (NSW), Australia, and Scotland (1995-2011/2012/2013, respectively) were linked to HCC diagnosis data via hospital admissions (2001-2012/2013/2014, respectively), and mortality (1995-2013/2014/2015, respectively). Age-standardised HCC incidence rates were evaluated, associated factors were assessed using Cox regression, and median survival time after HCC diagnosis was calculated...
November 30, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29193034/hypermanganesemia-with-dystonia-polycythemia-and-cirrhosis-in-10-patients-six-novel-slc30a10-mutations-and-further-phenotype-delineation
#19
M S Zaki, M Y Issa, H M Elbendary, H El-Karaksy, H Hosny, C Ghobrial, A El Safty, A El-Hennawy, A Oraby, L Selim, M S Abdel-Hamid
Biallelic mutations in the SLC30A10 gene cause an inborn error of Mn metabolism characterized by hypermanganesemia, polycythemia, early-onset dystonia, and liver cirrhosis (HMDPC). To-date only 14 families from various ethnic groups have been reported. Here, we describe 10 patients from 7 unrelated Egyptian families with HMDPC. Markedly elevated blood Mn levels, the characteristic basal ganglia hyperintensity on T1W images, and variable degrees of extrapyramidal manifestations with or without liver disease were cardinal features in all patients...
November 28, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#20
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
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