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Diagnosis of hepatitis c

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https://www.readbyqxmd.com/read/29034998/the-albumin-bilirubin-grade-uncovers-the-prognostic-relationship-between-hepatic-reserve-and-immune-dysfunction-in-hiv-associated-hepatocellular-carcinoma
#1
D J Pinato, R Sharma, C Citti, H Platt, M Ventura-Cots, E Allara, T-Y Chen, A Dalla Pria, M Jain, B Mínguez, L Kikuchi, E Kaufman West, M Merli, D E Kaplan, H Hasson, K Marks, M Nelson, M Núñez, A Aytaman, M Bower, N Bräu
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of liver-related mortality in people living with HIV, where co-infection with hepatotropic viruses accelerates the course of chronic liver disease. AIM: To evaluate whether the albumin-bilirubin (ALBI) grade, a more accurate marker of liver dysfunction in HCC, might identify patients with progressive liver dysfunction in the context of HIV/hepatitis co-infection. METHODS: Using uni- and multi-variable analyses, we studied the albumin-bilirubin grade as a predictor of overall survival (OS) in a large, multi-center cohort of patients with HIV-associated HCC recruited from 44 centres in 9 countries within the Liver Cancer in HIV study group...
October 16, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29027535/transplant-glomerulopathy
#2
REVIEW
Edward J Filippone, Peter A McCue, John L Farber
In the renal allograft, transplant glomerulopathy represents a morphologic lesion and not a specific diagnosis. The hallmark pathologic feature is glomerular basement membrane reduplication by light microscopy or electron microscopy in the absence of immune complex deposits. Transplant glomerulopathy results from chronic, recurring endothelial cell injury that can be mediated by HLA alloantibodies (donor-specific antibodies), various autoantibodies, cell-mediated immune injury, thrombotic microangiopathy, or chronic hepatitis C...
October 13, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29023176/induction-of-vogt-koyanagi-harada-disease-by-interferon-alpha-and-ribavirin-treatment-in-patients-with-hepatitis-c-a-case-report-and-review-of-the-literature
#3
Jialiang Duan, Yang Wang, Danyan Liu, Jingxue Ma
PURPOSE: To describe a case of Vogt-Koyanagi-Harada disease (VKH) presenting in a hepatitis C patient after interferon-alpha (IFN-α) and ribavirin treatment. METHODS: A retrospective review of our patient and a review of the published literature. RESULTS: A 59 year-old man developed VKH after the four months of IFN-α and ribavirin therapy for hepatitis C. The patient's VKH was controlled by systemic corticosteroids. The relationship between VKH and IFN-α is discussed based on the published literature...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29023152/primary-hepatic-neoplasms-of-vascular-origin-key-imaging-features-and-differential-diagnoses-with-radiology-pathology-correlation
#4
Hailey Hye-In Choi, Maria A Manning, Anupamjit K Mehrotra, Sean Wagner, Reena C Jha
OBJECTIVE: This article describes, illustrates, and correlates imaging and pathologic features of primary vascular mesenchymal neoplasms of the liver, which arise from the vascular endothelium and perivascular epithelioid cells. CONCLUSION: Familiarity with the spectrum of benign, malignant-potential and malignant vascular neoplasms, and nonneoplastic mimickers allows consideration in the differential diagnosis of enhancing hepatic masses. Understanding relevant pathologic features facilitates recognition of key imaging features, specifically dynamic contrast enhancement patterns on CT and MRI, which provide a useful classification system...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29021079/blood-borne-virus-transmission-in-an-urban-culturally-diverse-neighbourhood-results-from-a-cross-sectional-bio-behavioural-survey-using-innovative-outreach-methods-in-a-hard-to-reach-population
#5
Elizabeth Peach, Shelley Cogger, Kat Byron, Penny Francis, Daniel O'Keefe, Peter Higgs, Mark Stoove, Kasey Elmore, Paul Dietze, Margaret Hellard
Background: Following a HIV outbreak among Aboriginal people in a culturally diverse inner-city suburb of Melbourne, a blood-borne virus (BBV) screening program was conducted to inform public health interventions to prevent transmission and facilitate timely diagnosis and linkage to care. Methods: In August-September 2014, community health workers recruited people who inject drugs (PWID) from a local needle and syringe program. Participants were tested for hepatitis C virus (HCV), hepatitis B virus (HBV), HIV and syphilis and completed a bio-behavioural questionnaire...
October 12, 2017: Sexual Health
https://www.readbyqxmd.com/read/29020023/the-continuous-reaction-time-test-for-minimal-hepatic-encephalopathy-validated-by-a-randomized-controlled-multi-modal-intervention-a-pilot-study
#6
M M Lauridsen, S Mikkelsen, T Svensson, J Holm, C Klüver, J Gram, H Vilstrup, O B Schaffalitzky de Muckadell
BACKGROUND: Minimal hepatic encephalopathy (MHE) is clinically undetectable and the diagnosis requires psychometric tests. However, a lack of clarity exists as to whether the tests are in fact able to detect changes in cognition. AIM: To examine if the continuous reaction time test (CRT) can detect changes in cognition with anti-HE intervention in patients with cirrhosis and without clinically manifest hepatic encephalopathy (HE). METHODS: Firstly, we conducted a reproducibility analysis and secondly measured change in CRT induced by anti-HE treatment in a randomized controlled pilot study: We stratified 44 patients with liver cirrhosis and without clinically manifest HE according to a normal (n = 22) or abnormal (n = 22) CRT...
2017: PloS One
https://www.readbyqxmd.com/read/29019744/pediatric-liver-transplant-techniques-and-complications
#7
Natally Horvat, Antonio Sergio Zafred Marcelino, Joao Vicente Horvat, Tássia Regina Yamanari, Jose de Arimateia Batista Araújo-Filho, Pedro Panizza, Joao Seda-Neto, Eduardo Antunes da Fonseca, Francisco Cesar Carnevale, Luciana Mendes de Oliveira Cerri, Paulo Chapchap, Giovanni Guido Cerri
Liver transplant is considered to be the last-resort treatment approach for pediatric patients with end-stage liver disease. Despite the remarkable advance in survival rates, liver transplant remains an intricate surgery with significant morbidity and mortality. Early diagnosis of complications is crucial for patient survival but is challenging given the lack of specificity in clinical presentation. Knowledge of the liver and vascular anatomy of the donor and the recipient or recipients before surgery is also important to avoid complications...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28994127/the-negative-impact-of-hbv-hcv-coinfection-on-cirrhosis-and-its-consequences
#8
S Pol, G Haour, H Fontaine, C Dorival, V Petrov-Sanchez, M Bourliere, J Capeau, P Carrieri, D Larrey, C Larsen, P Marcellin, J-M Pawlostky, P Nahon, F Zoulim, P Cacoub, V de Ledinghen, P Mathurin, F Negro, G-P Pageaux, Y Yazdanpanah, L Wittkop, J-P Zarski, F Carrat
BACKGROUND: Hepatitis B virus (HBV)/hepatitis C virus (HCV) confection has been rarely studied in nonasian series. AIM: To compare the characteristics of HBV/HCV coinfected patients to those of HBV- or HCV-monoinfected patients in the ANRS CO22 HEPATHER cohort study. PATIENTS AND METHODS: Of the 20 936 included patients, 95 had HBV/HCV coinfection (hepatitis B surface antigen, anti-HCV antibody and HCV RNA positive) and were matched with 375 HBV- and 380 HCV-monoinfected patients on age, gender and time since HBV or HCV diagnosis...
October 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28989828/magnetic-resonance-imaging-of-primary-hepatic-malignancies-in-patients-with-and-without-chronic-liver-disease-a-pictorial-review
#9
REVIEW
Lauren F Alexander, Peter Harri, Brent Little, Courtney C Moreno, Pardeep K Mittal
Primary hepatic malignancies are less common than metastatic diseases, but a recognition of these lesions is important for diagnosis and treatment planning. Magnetic resonance imaging (MRI) provides the most imaging information to diagnose lesions noninvasively and to narrow differential diagnoses. This paper reviews the imaging findings of chronic liver disease and primary hepatic malignancies, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA), epithelioid hemangioendothelioma, hepatic angiosarcoma, and primary hepatic lymphoma...
August 4, 2017: Curēus
https://www.readbyqxmd.com/read/28984055/daily-cannabis-and-reduced-risk-of-steatosis-in-human-immunodeficiency-virus-and-hepatitis-c-virus-co-infected-patients-anrs-co13-hepavih
#10
Sandra Nordmann, Antoine Vilotitch, Perrine Roux, Laure Esterle, Bruno Spire, Fabienne Marcellin, Dominique Salmon-Ceron, François Dabis, Julie Chas, David Rey, Linda Wittkop, Philippe Sogni, Patrizia Carrieri
Liver steatosis is common in Human Immunodeficiency Virus (HIV) - Hepatitis C Virus (HCV) co-infected patients. Some recent studies have found that cannabis use is negatively associated with insulin resistance in the general population and in HIV-HCV co-infected patients. Given the causal link between insulin resistance and steatosis, we hypothesized that cannabis use has a positive impact on steatosis. Therefore, we aimed to study whether cannabis use in this population was associated with a reduced risk of steatosis, measured by ultrasound examination...
October 6, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28975833/the-role-of-diagnosis-and-treatment-of-underlying-liver-disease-for-the-prognosis-of-primary-liver-cancer
#11
Ashok Shiani, Shreya Narayanan, Luis Pena, Mark Friedman
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Underlying chronic liver disease has been associated with an increased risk of developing HCC. This study is a review of the current literature regarding the diagnosis, prognostic significance, and role of treating underlying liver disease in patients who are at risk of primary liver cancer. Relevant peer review of the English literature between 1980 and 2017 within PubMed and the Cochrane library was conducted for scientific content on current advances in managing chronic liver diseases and the development of hepatocellular carcinoma...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28975595/risk-factors-for-non-alcoholic-fatty-liver-disease-are-common-in-patients-with-non-b-non-c-hepatocellular-carcinoma-in-india
#12
Deepu David, Anantharam Raghavendran, Ashish Goel, C Bharath Kumar, Thomas Alex Kodiatte, Deepak Burad, Priya Abraham, Banumathi Ramakrishna, Philip Joseph, Jeyamani Ramachandran, C E Eapen
AIM OF THE STUDY: The aim of the study was to analyze the prevalence of risk factors for non-alcoholic fatty liver disease (NAFLD) in patients with non-B non-C hepatocellular carcinoma (HCC). METHODS: Between June 2012 and November 2014, patients with HCC, negative for hepatitis B surface antigen and hepatitis C virus antibody, were included in this study. All patients were assessed for risk factors for NAFLD such as diabetes mellitus (DM), hypertension, dyslipidemia, metabolic syndrome, and obesity...
October 4, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28974899/natural-history-of-covert-hepatic-encephalopathy-an-observational-study-of-366-cirrhotic-patients
#13
An-Jiang Wang, A-Ping Peng, Bi-Min Li, Na Gan, Li Pei, Xue-Lian Zheng, Jun-Bo Hong, Hai-Ying Xiao, Jia-Wei Zhong, Xuan Zhu
AIM: To explore the natural history of covert hepatic encephalopathy (CHE) in absence of medication intervention. METHODS: Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and evaluated for CHE diagnosis. They were followed up for a mean of 11.2 ± 1.3 mo. Time to the first cirrhosis-related complications requiring hospitalization, including overt HE (OHE), resolution of CHE and death/transplantation, were compared between CHE and no-CHE patients...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28974107/comparison-of-the-hepatitis-c-continua-of-care-between-hcv-hiv-co-infected-and-hcv-mono-infected-patients-in-two-treatment-eras-during-2008-2015
#14
Jeffrey Landon Roberson, Alicia M Lagasca, Virginia L Kan
Treatment of chronic Hepatitis C Virus (HCV) infection included use of pegylated interferon-based regimens prior to 2014 and direct acting agents (DAA) since 2014 at the VA Medical Center in Washington, DC. We compared the continua of care between our HCV/HIV co-infected and HCV mono-infected patients during 2008-2015. A review of summary data from our local HCV Clinical Case Registry was conducted for the interferon treatment era (2008-2013) and the DAA era (2014-2015). Data were analyzed on a modified HCV Continuum of Care (CoC) based on these stages: HCV diagnosis, engagement in medical care, HCV treatment, and HCV sustained virologic response (SVR) for differences between HCV/HIV co-infected and HCV mono-infected patients...
October 3, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28969594/identification-of-compound-heterozygous-patients-with-primary-hyperoxaluria-type-1-clinical-evaluations-and-in-silico-investigations
#15
Houda Kanoun, Faiçal Jarraya, Bayen Maalej, Amina Lahiani, Hichem Mahfoudh, Fatma Makni, Jamil Hachicha, Faiza Fakhfakh
BACKGROUND: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder of glyoxylate metabolism in which excessive oxalates are formed by the liver and excreted by the kidneys. Calcium oxalate crystallizes in the urine, leading to urolithiasis, nephrocalcinosis, and consequent renal failure if treatment is not initiated promptly. Mutations in the AGXT gene which encodes the hepatic peroxisomal enzyme alanine:glyoxylate aminotransferase are responsible of PH1. In the present work, we aimed to analyze AGXT gene and in silico investigations performed in four patients with PH1 among two non consanguineous families...
October 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28960812/pilot-study-for-hepatitis-virus-screening-among-employees-and-effective-approach-to-encourage-screened-positive-employees-to-receive-medical-care-in-japan
#16
Aya Sugiyama, Toshiko Fujii, Shintaro Nagashima, Masayuki Ohisa, Chikako Yamamoto, Chuon Channarena, Tomoyuki Akita, Junko Matsuo, Keiko Katayama, Kazuaki Takahashi, Junko Tanaka
BACKGROUND & AIMS: Countermeasures against hepatitis B and C virus (HBV, HCV) infection at work sites in Japan have not yet been implemented. This study aimed to determine the status of viral hepatitis infection among the employees in Japan. METHODS: We conducted a workplace-based cross-sectional study from 2011 to 2016 in Hiroshima. HBV and HCV markers were identified during a routine checkup of employees in 15 enterprises. The screening results were sent to employees directly and not to employers...
September 27, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28960360/survival-after-treatment-with-curative-intent-for-hepatocellular-carcinoma-among-patients-with-vs-without-non-alcoholic-fatty-liver-disease
#17
C R Wong, B Njei, M H Nguyen, A Nguyen, J K Lim
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully selected patients. AIM: To compare survival after receipt of curative treatment for NAFLD and non-NAFLD-HCC aetiologies (HCV, chronic hepatitis C; HBV, chronic hepatitis B; ALD, alcoholic liver disease) and by treatment was performed...
September 28, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28957037/evaluation-of-the-impact-of-mandating-health-care-providers-to-offer-hepatitis-c-virus-screening-to-all-persons-born-during-1945-1965-new-york-2014
#18
Colleen A Flanigan, Shu-Yin J Leung, Kirsten A Rowe, Wendy K Levey, Andrea King, Jamie N Sommer, Johanne E Morne, Howard A Zucker
Approximately 75% of all hepatitis C virus (HCV) infections in the United States and 73% of HCV-associated mortality occur in persons born during 1945-1965, placing this birth cohort at increased risk for liver cancer and other HCV-related liver disease (1). In the United States, an estimated 2.7 million persons are living with HCV infection, and it is estimated that up to 75% of these persons do not know their status. Since 2012, CDC has recommended that persons born during 1945-1965 receive one-time HCV testing...
September 29, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28954412/rising-rates-of-hepatocellular-carcinoma-leading-to-liver-transplantation-in-baby-boomer-generation-with-chronic-hepatitis-c-alcohol-liver-disease-and-nonalcoholic-steatohepatitis-related-liver-disease
#19
George Cholankeril, Eric R Yoo, Ryan B Perumpail, Andy Liu, Jeevin S Sandhu, Satheesh Nair, Menghan Hu, Aijaz Ahmed
We aim to study the impact of the baby boomer (BB) generation, a birth-specific cohort (born 1945-1965) on hepatocellular carcinoma (HCC)-related liver transplantation (LT) in patients with chronic hepatitis C virus (HCV), alcoholic liver disease (ALD), and non-alcoholic steatohepatitis (NASH). We performed a retrospective analysis using the United Network for Organ Sharing (UNOS)/Organ Procurement Transplant Network (OPTN) database from 2003 to 2014 to compare HCC-related liver transplant surgery trends between two cohorts-the BB and non-BB-with a secondary diagnosis of HCV, ALD, or NASH...
September 26, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28951076/incidental-finding-of-severe-hypertriglyceridemia-in-children-role-of-multiple-rare-variants-in-genes-affecting-plasma-triglyceride
#20
Paola Sabrina Buonuomo, Claudio Rabacchi, Marina Macchiaiolo, Chiara Trenti, Tommaso Fasano, Patrizia Tarugi, Andrea Bartuli, Stefano Bertolini, Sebastiano Calandra
BACKGROUND: The incidental finding of severe hypertriglyceridemia (HyperTG) in a child may suggest the diagnosis of familial chylomicronemia syndrome (FCS), a recessive disorder of the intravascular hydrolysis of triglyceride (TG)-rich lipoproteins. FCS may be due to pathogenic variants in lipoprotein lipase (LPL), as well as in other proteins, such as apolipoprotein C-II and apolipoprotein A-V (activators of LPL), GPIHBP1 (the molecular platform required for LPL activity on endothelial surface) and LMF1 (a factor required for intracellular formation of active LPL)...
September 4, 2017: Journal of Clinical Lipidology
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