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Cancer of the esophagus

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https://www.readbyqxmd.com/read/29333062/helicobacter-pylori-infection-and-esophageal-adenocarcinoma-a-review-and-a-personal-view
#1
REVIEW
Stergios A Polyzos, Christos Zeglinas, Fotini Artemaki, Michael Doulberis, Evangelos Kazakos, Panagiotis Katsinelos, Jannis Kountouras
Esophageal adenocarcinoma (EAC) is etiologically associated with gastroesophageal reflux disease (GERD). There is evidence to support the sequence GERD, Barrett's esophagus (BE), dysplasia, and finally EAC, with Helicobacter pylori (H. pylori) being implicated in each step to EAC. On the other side of this relation stands the hypothesis of the protective role of H. pylori against EAC. Based on this controversy, our aim was to review the literature, specifically original clinical studies and meta-analyses linking H...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29330747/recent-advances-in-screening-for-barrett-s-esophagus
#2
REVIEW
Sarmed S Sami, Prasad G Iyer
OPINION STATEMENT: PURPOSE OF REVIEW: There is a pressing need for effective strategies to halt the increase in both the incidence and mortality of esophageal adenocarcinoma (EAC). Screening for Barrett's esophagus, which is the only known precursor of EAC, remains a ripe area for research, particularly with regard to identifying the target population, screening tools, and management of screen-detected populations. This review aims to explore in depth the rationale for screening for Barrett's esophagus, recent biotechnological advances which may have the potential of making screening feasible, and also highlight the challenges which will have to be overcome in order make screening for BE a realistic prospect...
January 13, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29327473/risk-assessment-for-metalworking-fluids-and-cancer-outcomes
#3
Robert M Park
BACKGROUND: Metalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk. METHODS: Using published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation. RESULTS: Cancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix...
January 12, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29321605/trends-and-patterns-of-cancer-mortality-in-north-china-hebei-province-1973-2013
#4
Di Liang, Daojuan Li, Jianghui Liu, Jing Jin, Jin Shi, Baoen Shan, Yutong He
Little was known about the cancer burden for the last 40 years in middle-income province in China. This study aimed to assess the overall, cause-specific mortality cancer trend and disability-adjusted life years (DALYs) between 1973-1975 and 2011-2013 in North China (Hebei Province). The collected data were stratified by 5-year age groups, gender and different types of cancer. We found that mortality from cancer showed an upward trend in the 1973-2013. The mortality rate of 0-79 year-old in 2011-2013 was lower than that in other periods...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316808/impact-of-prior-malignancy-on-outcomes-of-stage-iv-esophageal-carcinoma-seer-based-study
#5
Anas M Saad, Muneer J Al-Husseini, Ahmed Elgebaly, Omar A Aboshady, Sami Salahia, Omar Abdel-Rahman
INTRODUCTION: Usually, clinical trials on esophageal cancer exclude patients with a prior malignancy, assuming that this may influence survival outcomes. However, little is known about the impact of a prior malignancy on its prognosis. METHODOLOGY: The Surveillance, Epidemiology, and End Results database (SEER) was used to review patients with stage IV squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus during 1973-2014. We calculated overall and esophageal cancer-specific survival using unadjusted Kaplan-Meier and multivariable covariate-adjusted Cox models...
January 10, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29313724/early-enteral-nutrition-is-associated-with-faster-post-esophagectomy-recovery-in-chinese-esophageal-cancer-patients-a-retrospective-cohort-study
#6
Hongyu Han, Meixia Pan, Yang Tao, Runzhong Liu, Zhiliang Huang, Korinne Piccolo, Caiyun Zhong, Ranyi Liu
We retrospectively examined a large cohort of esophageal carcinoma patients who received early enteral nutrition (EEN) to clarify the validity of EEN compared with total parenteral nutrition (TPN). Included were a total of 665 consecutive patients with histologically confirmed carcinoma of the esophagus or esophagogastric junction; and all patients underwent esophagectomy. The patients were divided into two groups: TPN (n = 262) and EEN (n = 403). The TPN group consisted of patients who only received intravenous nutrition support after operation...
January 9, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29312726/is-a-clinical-target-volume-ctv-necessary-for-locally-advanced-non-small-cell-lung-cancer-treated-with-intensity-modulated-radiotherapy-a-dosimetric-evaluation-of-three-different-treatment-plans
#7
Fan Xia, Lijun Zhou, Xi Yang, Li Chu, Xiaofei Zhang, Jinjin Chu, Weigang Hu, Zhengfei Zhu
Background: The aim of this study was to determine the feasibility of omitting the clinical target volume (CTV) in patients with locally advanced non-small cell lung cancer (NSCLC) treated with intensity-modulated radiotherapy (IMRT) by comparing dosimetric characteristics of three different IMRT plans with or without CTV implementation. Methods: Thirteen patients with stage III NSCLC were reviewed. Target volumes were contoured such that the planning target volume (PTV) derived from the gross tumor volume (GTV) directly was named PTV_g and that from GTV plus CTV margin was named PTV_c...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29294573/-multivariate-ordinal-logistic-regression-analysis-on-the-association-between-consumption-of-fried-food-and-both-esophageal-cancer-and-precancerous-lesions
#8
L W Guo, S Z Liu, M Zhang, Q Chen, S K Zhang, X B Sun
Objective: To investigate the effect of fried food intake on the pathogenesis of esophageal cancer and precancerous lesions. Methods: From 2005 to 2013, all the residents aged 40-69 years from 11 counties (cities) where cancer screening of upper gastrointestinal cancer had been conducted in rural areas of Henan province, were recruited as the subjects of study. Information on demography and lifestyle was collected. The residents under study were screened with iodine staining endoscopic examination and biopsy samples were diagnosed pathologically, under standardized criteria...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29290788/investigating-esophageal-stent-placement-outcomes-in-patients-with-inoperable-non-cervical-esophageal-cancer
#9
Mojgan Forootan, Morteza Tabatabaeefar, Nariman Mosaffa, Hormat Rahimzadeh Ashkalak, Mohammad Darvishi
Background: Esophageal stent insertion in patients with inoperable esophageal cancer is usually accompanied with relatively high adverse symptoms and even mortality. The current study aims at investigating the outcomes of esophageal stenting in patients with inoperable non-cervical esophageal cancer. Materials and Methods: The current descriptive-analytical research evaluates 25 patients with esophageal cancer. The stent was placed in esophagus based upon endoscopy analysis with or without fluoroscopy and then the stent position and its opening was investigated by making use of CXRand Gastrografin studies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290655/endoscopic-ultrasound-staging-for-early-esophageal-cancer-are-we-denying-patients-neoadjuvant-chemo-radiation
#10
Carrie Luu, Marisa Amaral, Jason Klapman, Cynthia Harris, Khaldoun Almhanna, Sarah Hoffe, Jessica Frakes, Jose M Pimiento, Jacques P Fontaine
AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in early esophageal cancer (EC) performed in a high-volume tertiary cancer center. METHODS: A retrospective review of patients undergoing esophagectomy was performed and patients with cT1N0 and cT2N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29289868/avoiding-the-ingestion-of-cytotoxic-concentrations-of-ethanol-may-reduce-the-risk-of-cancer-associated-with-alcohol-consumption
#11
Emilio Guillén-Mancina, José Manuel Calderón-Montaño, Miguel López-Lázaro
Alcohol consumption is a known risk factor for cancer. Almost 6% of all cancers worldwide are attributable to alcohol use. Approximately half of them occur in tissues highly exposed to ethanol, such as the oral cavity, pharynx, upper larynx and esophagus. However, since ethanol is not mutagenic and the mutagenic metabolite of ethanol (acetaldehyde) is mainly produced in the liver, it is unclear why alcohol consumption preferentially exerts a local carcinogenic effect. Recent findings indicate that the risk of cancer in a tissue is strongly correlated with the number of stem cell divisions accumulated by the tissue; the accumulation of stem cell divisions leads to the accumulation of cancer-promoting errors such as mutations occurring during DNA replication...
December 27, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29288659/the-learning-curve-for-robotic-mckeown-esophagectomy-in-patients-with-esophageal-cancer
#12
Hanlu Zhang, Longqi Chen, Zihao Wang, Yu Zheng, Yingcai Geng, Fuqiang Wang, Dan Liu, Andong He, Lin Ma, Yong Yuan, Yun Wang
BACKGROUND: Robot-assisted McKeown esophagectomy (RAME) is a promising but technically demanding procedure, so a learning curve should be defined to guide training and allow implementation of this technique. METHODS: This study retrospectively reviewed a prospectively collected data of 72 consecutive patients undergoing RAME by a single surgical team experienced in open and thoracolaparoscopic esophagectomy. The cumulative sum (CUSUM) method was used to analyse the learning curve...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29285641/core-body-temperature-but-not-intraabdominal-pressure-predicts-postoperative-complications-following-closed-system-hyperthermic-intraperitoneal-chemotherapy-hipec-administration
#13
M Goldenshluger, D Zippel, A Ben-Yaacov, J Dux, T Yalon, A Zendel, S Rayman, E Mor, H Berkenstadt, H Fogel-Grinvald, M Ventorrero, A Nissan
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery (CRS), performed using closed-abdomen technique (CAT), may affect intraabdominal pressure (IAP). High IAP may increase postoperative complications due to decreased venous return and hypoperfusion to vital organs. Elevated core body temperature (CBT) may cause multiorgan dysfunction. Low IAP or CBT could result in suboptimal HIPEC and potentially translate into early disease recurrence. The aim of the present study is to identify possible correlations between IAP or CBT and postoperative complications...
December 29, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29285374/stereotactic-body-radiotherapy-for-oligo-recurrence-in-the-liver-in-a-patient-with-esophageal-carcinoma-a-case-report
#14
Atsuto Katano, Hideomi Yamashita, Keiichi Nakagawa
Stereotactic body radiation therapy (SBRT) is a safe and effective treatment for solitary cancerous lesions. The present study reported a rare case of sustained remission after SBRT for oligorecurrence in the liver in a patient with esophageal carcinoma. A 60-year-old Japanese man presented with a chief complaint of dysphagia. On medical examination, the patient was diagnosed as having squamous cell carcinoma of the esophagus that was clinically staged as T4bN1M0. The patient received definitive concurrent chemoradiotherapy, consisting of four 28-day cycles of chemotherapy comprising nedaplatin 80 mg/m2 on day 1 and S-1 120 mg/body orally on days 1-14, with radiotherapy comprising a total of 50 Gy in daily fractions of 2 Gy...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285246/gene-function-analysis-and-underlying-mechanism-of-esophagus-cancer-based-on-microarray-gene-expression-profiling
#15
Ying Yue, Mengjia Song, Yamin Qiao, Pupu Li, Yiqiang Yuan, Jingyao Lian, Suying Wang, Yi Zhang
Esophageal cancer (EC) is one of the most common digestive malignant tumors worldwide. Over the past decades, there have been minimal improvements in outcomes for patients with EC. New targets and novel therapies are needed to improve outcomes for these patients. This study aimed to explore the molecular mechanisms of EC by integrated bioinformatic analyses of the feature genes associated with EC and correlative gene functions which can distinguish cancerous tissues from non-cancerous tissues. Gene expression profile GSE20347 was downloaded from Gene Expression Omnibus (GEO) database, including 17 EC samples and their paired adjacent non-cancerous samples...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282511/locoregional-tumor-extension-and-preoperative-smoking-are-significant-risk-factors-for-early-recurrence-after-esophagectomy-for-cancer
#16
Styliani Mantziari, Pierre Allemann, Michael Winiker, Nicolas Demartines, Markus Schäfer
BACKGROUND: Tumor recurrence during the first year after oncological esophagectomy has been reported in up to 17-66% of patients. However, little is known as to the risk factors potentially associated with this adverse outcome. The aim of this retrospective observational study was to identify clinically relevant parameters associated with early recurrence. METHODS: All patients with squamous cell cancer or adenocarcinoma of the esophagus or gastroesophageal junction, operated with curative intent in our center from 2000 to 2014, were screened for this study...
December 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29279695/undiagnosed-esophageal-adenocarcinoma-presenting-as-multiple-brain-metastases
#17
Vincent Grzywacz, Ernie Balcueva
Brain metastases from gastrointestinal malignancies are exceedingly rare occurrences that carry a very poor prognosis. This holds especially true in cases where brain metastases from esophageal primaries are the initial presentation of a previously unidentified gastrointestinal malignancy. Our patient, a 60-year-old male with a past history of a right temporal teratoma, family history of breast cancer, and no smoking history, presented with a chief complaint of recurrent headaches. His history of present illness and physical examination included a two-month history of frontal headache, progressive fatigue, and unintentional weight loss...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29250106/update-on-the-management-of-barrett-s-esophagus-in-austria
#18
M Riegler, I Kristo, M Nikolic, E Rieder, S F Schoppmann
Background: Barrett's esophagus (BE) is the premalignant manifestation of gastroesophageal reflux disease (GERD). Radiofrequency ablation (RFA) with and without endoscopic resection (ER) is a novel treatment for BE. Methods: Here we present a single-center update of the recommendations of a recent (June 2015) interdisciplinary expert panel meeting on the management of BE with dysplasia as well as cancer-positive and cancer-negative BE. We conducted a PubMed search of studies published in 2016 and 2017 on the topic of BE and RFA...
2017: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29249048/a-14-year-study-of-398-esophageal-adenocarcinomas-diagnosed-among-156-256-egds-performed-at-two-large-hospitals-an-inlet-patch-is-proposed-as-a-significant-risk-factor-for-proximal-esophageal-adenocarcinoma
#19
Molly Orosey, Mitual Amin, Mitchell S Cappell
BACKGROUND: An association between inlet patches and proximal esophageal adenocarcinomas is currently suspected because of numerous case reports of simultaneous occurrence of both diseases. AIMS: To analyze whether inlet patches are significantly associated with proximal esophageal adenocarcinomas in a large population. METHODS: Computerized search of pathology and EGD reports revealed 398 cases of esophageal adenocarcinomas among 156,236 EGDs (performed on 106,510 patients) diagnosed by histopathology performed at Royal Oak/Troy, William Beaumont Hospitals, 2003-2016...
December 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29248129/the-distribution-of-cancer-cases-in-somalia
#20
Yılmaz Baş, Hussein Abshir Hassan, Cevdet Adıgüzel, Oktay Bulur, İkram Abdikarim Ibrahim, Seçil Soydan
OBJECTIVE: The aim of this study was to investigate the frequency and distribution of cancer cases in a defined time period in Somalia. MATERIALS AND METHODS: A total of 403 cancer cases were diagnosed between January 01, 2016 and March 01, 2017 in the Department of Pathology at the Somalia Mogadishu-Turkey Education and Research Hospital or the Department of Oncology at Uniso Hospital, Somalia University. Data on cancer type, patient age, and gender were obtained from pathology reports and hospital records...
June 2017: Seminars in Oncology
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