Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Coline H M van Moorsel, Hendrik W van Es, Frouke T van Beek, Marjolijn H L Struik, Maria Kokosi, Ryoko Egashira, Anne Laure Brun, Arjun Nair, Simon L F Walsh, Gary Cross, Joseph Barnett, Angelo de Lauretis, Eoin P Judge, Sujal Desai, Ronald Karwoski, Sebastien Ourselin, Elisabetta Renzoni, Toby M Maher, Andre Altmann, Athol U Wells
AIMS: To determine whether computer-derived computed tomography measures, specifically measures of pulmonary vessel-related structures, can better predict functional decline and survival in idiopathic pulmonary fibrosis (IPF) and reduce requisite sample sizes in drug trial populations. METHODS: IPF patients undergoing volumetric non-contrast CT imaging at the Royal Brompton Hospital, London and St Antonius Hospital, Utrecht, were examined to identify pulmonary functional measures (including forced vital capacity), and visual and computer-derived (CALIPER) CT features predictive of mortality and forced vital capacity decline...
April 23, 2018: American Journal of Respiratory and Critical Care Medicine