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Hacohen, yael

Yael Hacohen, Sukhvir Wright, Jonathan Gadian, Angela Vincent, Ming Lim, Evangeline Wassmer, Jean-Pierre Lin
Expressive dysphasia and mutism are common clinical features in children and adults with N-methyl-d-aspartate receptor antibodies (NMDAR-Ab) encephalitis, and are likely to result from NMDAR hypofunction. A prodromal loss of social and communication skills can typify that of an autistic regression, particularly when presenting under the age of 3 years. Here we describe two toddlers who presented with developmental regression, particularly of their social communication skills, mimicking an autistic regression, who were found to have NMDAR-Ab in the serum and cerebrospinal fluid...
October 2016: Developmental Medicine and Child Neurology
Yael Hacohen, Yukihiro Nishimoto, Yuki Fukami, Bethan Lang, Patrick Waters, Ming J Lim, Nobuhiro Yuki, Angela Vincent
AIM: Central nervous system (CNS) autoantibodies have been reported in a range of neuroimmune diseases, but there has not been a systematic evaluation of autoantibodies in paediatric patients with brainstem encephalitis. METHOD: Serum samples from 57 children (40 male, 17 female, median age 12y, range 0.6-18y) with a diagnosis of brainstem encephalitis were tested retrospectively for antibodies to GQ1b, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), N-methyl-D-aspartate receptor, LGI1, CASPR2, glycine receptor (GlyR), DPPX, and the voltage gated potassium channel (VGKC)-complex...
August 2016: Developmental Medicine and Child Neurology
Nicholas M Allen, Yael Hacohen, Jacqueline Palace, David Beeson, Angela Vincent, Heinz Jungbluth
No abstract text is available yet for this article.
February 16, 2016: Neurology
Sekhar C Pillai, Shekeeb S Mohammad, Yael Hacohen, Esther Tantsis, Kristina Prelog, Elizabeth H Barnes, Deepak Gill, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale
To define the risk factors for postencephalitic epilepsy (PE) and drug-resistant epilepsy (DRE) in childhood following infectious and autoimmune encephalitis, we included 147 acute encephalitis patients with a median follow-up of 7.3 years (range 2-15.8 years). PE was defined as the use of antiepileptic drugs (AEDs) for ≥24 months, and DRE was defined as the persistence of seizures despite ≥2 appropriate AEDs at final follow-up. PE and DRE were diagnosed in 31 (21%) and 15 (10%) of patients, respectively...
January 2016: Epilepsia
Sanduni Kariyawasam, Rahul R Singh, Jonathan Gadian, Daniel E Lumsden, Jean-Pierre Lin, Ata Siddiqui, Yael Hacohen, Michael Absoud, Ming Lim
OBJECTIVE: To identify clinical and radiological features of children that relapse following an initial presentation of acute disseminated encephalomyelitis (ADEM). METHODS: Clinical records and neuroimaging of children under the age of 16 years presenting with ADEM to a pediatric neurology referral center between 2006 and 2010 were evaluated. RESULTS: Of the 32 children with ADEM, 24 (7 female) with a median age of 4.8 (range 3-15) had a monophasic course...
September 2015: Multiple Sclerosis and related Disorders
Yael Hacohen, Rahul Singh, Meghan Rossi, Bethan Lang, Cheryl Hemingway, Ming Lim, Angela Vincent
OBJECTIVE: To assess the clinical and immunologic findings in children with voltage-gated potassium channel (VGKC)-complex antibodies (Abs). METHODS: Thirty-nine of 363 sera, referred from 2 pediatric centers from 2007 to 2013, had been reported positive (.100 pM) for VGKC-complex Abs. Medical records were reviewed retrospectively and the patients’ condition was independently classified as inflammatory (n 5 159) or noninflammatory (n 5 204). Positive sera (.100 pM) were tested/retested for the VGKC complex Ab–positive complex proteins LGI1 and CASPR2, screened for binding to live hippocampal neurons, and 12 high-titer sera (...
September 15, 2015: Neurology
Susan Byrne, Cathal Walsh, Yael Hacohen, Eyal Muscal, Joseph Jankovic, Amber Stocco, Russell C Dale, Angela Vincent, Ming Lim, Mary King
No abstract text is available yet for this article.
August 2015: Neurology® Neuroimmunology & Neuroinflammation
Alasdair Bamford, Belinda H A Crowe, Yael Hacohen, Jean-Pierre Lin, Antonia Clarke, Gareth Tudor-Williams, Vanessa Sancho-Shimizu, Angela Vincent, Ming Lim, Sunil P Pullaperuma
N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.
June 2015: Journal of the Pediatric Infectious Diseases Society
Yael Hacohen, Sameer Zuberi, Angela Vincent, Yanick J Crow, Nuno Cordeiro
No abstract text is available yet for this article.
July 28, 2015: Neurology
Ming Lim, Yael Hacohen, Angela Vincent
Antibody-mediated diseases of the central nervous system are a relatively new and challenging field in autoimmune neurologic disease and of major clinical importance in children and adults. The antibodies bind to cell-surface epitopes on neuronal or glial proteins, and the patients demonstrate either focal or more generalized clinical signs depending on the extent of brain regions targeted by the antibodies. The presence of seizures, movement disorders, autonomic dysfunction and sleep disorders, alongside neuroimaging and electrophysiological features may indicate a specific antibody-mediated disorder...
June 2015: Pediatric Clinics of North America
Sekhar C Pillai, Yael Hacohen, Esther Tantsis, Kristina Prelog, Vera Merheb, Alison Kesson, Elizabeth Barnes, Deepak Gill, Richard Webster, Manoj Menezes, Simone Ardern-Holmes, Sachin Gupta, Peter Procopis, Christopher Troedson, Jayne Antony, Robert A Ouvrier, Yann Polfrit, Nicholas W S Davies, Patrick Waters, Bethan Lang, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale
BACKGROUND AND OBJECTIVES: Pediatric encephalitis has a wide range of etiologies, clinical presentations, and outcomes. This study seeks to classify and characterize infectious, immune-mediated/autoantibody-associated and unknown forms of encephalitis, including relative frequencies, clinical and radiologic phenotypes, and long-term outcome. METHODS: By using consensus definitions and a retrospective single-center cohort of 164 Australian children, we performed clinical and radiologic phenotyping blinded to etiology and outcomes, and we tested archived acute sera for autoantibodies to N-methyl-D-aspartate receptor, voltage-gated potassium channel complex, and other neuronal antigens...
April 2015: Pediatrics
Yael Hacohen, Michael Absoud, Kumaran Deiva, Cheryl Hemingway, Petra Nytrova, Mark Woodhall, Jacqueline Palace, Evangeline Wassmer, Marc Tardieu, Angela Vincent, Ming Lim, Patrick Waters
OBJECTIVE: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). METHOD: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France...
April 2015: Neurology® Neuroimmunology & Neuroinflammation
Yael Hacohen, Leslie W Jacobson, Susan Byrne, Fiona Norwood, Abhimanu Lall, Stephanie Robb, Robertino Dilena, Monica Fumagalli, Alfred Peter Born, Debbie Clarke, Ming Lim, Angela Vincent, Heinz Jungbluth
BACKGROUND: Transient neonatal myasthenia gravis (TNMG) affects a proportion of infants born to mothers with myasthenia gravis (MG). Symptoms usually resolve completely within the first few months of life, but persistent myopathic features have been reported in a few isolated cases. METHODS: Here we report 8 patients from 4 families born to mothers with clinically manifest MG or mothers who were asymptomatic but had elevated acetylcholine receptor (AChR) antibody levels...
February 2015: Neurology® Neuroimmunology & Neuroinflammation
Richard E Rosch, Alasdair Bamford, Yael Hacohen, Elizabeth Wraige, Angela Vincent, Leena Mewasingh, Ming Lim
The pathogenesis of Guillain-Barré syndrome (GBS) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens. Antibodies to contactin-associated protein-like 2 (CASPR2), part of the voltage-gated potassium channel complex (VGKC-complex), are associated with neurological disease predominantly affecting the peripheral nervous system but are not known to be associated with GBS. We report two cases of ganglioside antibody-negative paediatric GBS associated with CASPR2 antibodies...
September 2014: Journal of the Peripheral Nervous System: JPNS
Yael Hacohen, Michael Absoud, Cheryl Hemingway, Leslie Jacobson, Jean-Pierre Lin, Mike Pike, Sunil Pullaperuma, Ata Siddiqui, Evangeline Wassmer, Patrick Waters, Sarosh R Irani, Camilla Buckley, Angela Vincent, Ming Lim
OBJECTIVE: To report the clinical and radiologic findings of children with NMDA receptor (NMDAR) antibodies and white matter disorders. METHOD: Ten children with significant white matter involvement, with or without anti-NMDAR encephalitis, were identified from 46 consecutive NMDAR antibody-positive pediatric patients. Clinical and neuroimaging features were reviewed and the treatment and outcomes of the neurologic syndromes evaluated. RESULTS: THREE DISTINCT CLINICORADIOLOGIC PHENOTYPES WERE RECOGNIZED: brainstem encephalitis (n = 3), leukoencephalopathy following herpes simplex virus encephalitis (HSVE) (n = 2), and acquired demyelination syndromes (ADS) (n = 5); 3 of the 5 with ADS had myelin oligodendrocyte glycoprotein as well as NMDAR antibodies...
June 2014: Neurology® Neuroimmunology & Neuroinflammation
Yael Hacohen, Rahul Singh, Vhari Forsyth, Michael Absoud, Ming Lim
OBJECTIVE: To evaluate the utility of qualitative and quantitative analyses of CSF immunoglobulins as part of the diagnostic workup of CNS inflammatory conditions. METHODS: One hundred eighty-nine children who underwent CSF investigation for their neurologic condition had CSF and serum testing to (1) qualitatively identify oligoclonal band (OCB) patterns and (2) quantitatively measure the immunoglobulin (Ig) G index and albumin quotient (QAlb). Case notes were retrospectively reviewed and patients were grouped according to whether their primary diagnosis was due to an inflammatory (n = 104) or noninflammatory (n = 85) etiology...
June 2014: Neurology® Neuroimmunology & Neuroinflammation
Yael Hacohen, Michael Absoud, Mark Woodhall, Carole Cummins, Christian G De Goede, Cheryl Hemingway, Philip E Jardine, Rachel Kneen, Michael G Pike, William P Whitehouse, Evangeline Wassmer, Patrick Waters, Angela Vincent, Ming Lim
BACKGROUND: Autoantibodies to glial, myelin and neuronal antigens have been reported in a range of central demyelination syndromes and autoimmune encephalopathies in children, but there has not been a systematic evaluation across the range of central nervous system (CNS) autoantibodies in childhood-acquired demyelinating syndromes (ADS). METHODS: Children under the age of 16 years with first-episode ADS were identified from a national prospective surveillance study; serum from 65 patients had been sent for a variety of diagnostic tests...
April 2014: Journal of Neurology, Neurosurgery, and Psychiatry
Yael Hacohen, Nomazulu Dlamini, Tammy Hedderly, Elaine Hughes, Martin Woods, Angela Vincent, Ming Lim
N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a well-recognized clinico-immunological syndrome that presents with a movement disorder, cognitive decline, psychiatric symptoms, and epileptic seizures. A pure monosymptomatic presentation is rare; however, some patients present predominantly with a movement disorder in the absence of encephalopathy. Here, we describe three paediatric patients with an NMDAR antibody-mediated movement disorder: a 5-year-old female with acute onset hemichorea, a 10-year-old female with generalized chorea, and a 12-year-old male with abdominal myoclonus...
February 2014: Developmental Medicine and Child Neurology
Yael Hacohen, Kumaran Deiva, Phillipa Pettingill, Patrick Waters, Ata Siddiqui, Pascale Chretien, Esse Menson, Jean-Pierre Lin, Marc Tardieu, Angela Vincent, Ming J Lim
Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity...
January 2014: Movement Disorders: Official Journal of the Movement Disorder Society
Yael Hacohen, Sonia Joseph, Rachel Kneen, Paul Eunson, Jean-Pierre Lin, Angela Vincent, Ming Lim
Immune-mediated limbic encephalitis affects both adults and children. Patients typically present with seizures, memory problems, and imaging changes in the medial temporal lobes. Both paraneoplastic and nonparaneoplastic forms have been described in which the antibody to the voltage-gated potassium channel-complex associated protein, leucine-rich glioma-inactivated 1, is most commonly reported. Elevated antithyroid antibodies have also been reported in a range of neurological syndromes with encephalopathy, such as limbic encephalitis, often collectively termed Hashimoto encephalopathy, a condition whereby corticosteroids responsiveness with a complete recovery is commonly observed...
June 2014: Journal of Child Neurology
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