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Hacohen, yael

Yael Hacohen, Olga Ciccarelli, Cheryl Hemingway
No abstract text is available yet for this article.
May 1, 2017: Brain: a Journal of Neurology
Alvin C C Ho, Shekeeb S Mohammad, Sekhar C Pillai, Esther Tantsis, Hannah Jones, Reena Ho, Ming Lim, Yael Hacohen, Angela Vincent, Russell C Dale
AIM: To determine the validity of the proposed clinical diagnostic criteria for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in paediatric patients. METHOD: The diagnostic criteria for anti-NMDAR encephalitis proposed by Graus et al. (2016) use clinical features and conventional investigations to facilitate early immunotherapy before antibody status is available. The criteria are satisfied if patients develop four out of six symptom groups within 3 months, together with at least one abnormal investigation (electroencephalography/cerebrospinal fluid) and reasonable exclusion of other disorders...
October 3, 2017: Developmental Medicine and Child Neurology
Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway
The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
Yael Hacohen, Kshitij Mankad, W K Chong, Frederik Barkhof, Angela Vincent, Ming Lim, Evangeline Wassmer, Olga Ciccarelli, Cheryl Hemingway
OBJECTIVE: To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main RDS for clinical use. METHODS: A panel reviewed the clinical characteristics, MOG-Ab and aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, and Epstein-Barr virus serology results of 110 children with RDS. A neuroradiologist blinded to the diagnosis scored the MRI scans...
July 18, 2017: Neurology
Yael Hacohen, Chirag B Patel, Rogier Hintzen
No abstract text is available yet for this article.
April 5, 2017: Neurology
Giulia Berzero, Yael Hacohen, Lars Komorowski, Madeleine Scharf, Caroline Dehais, Delphine Leclercq, Virginie Fourchotte, Bruno Buecher, Jérôme Honnorat, Francesc Graus, Jean-Yves Delattre, Dimitri Psimaras
No abstract text is available yet for this article.
March 2017: Neurology® Neuroimmunology & Neuroinflammation
Yael Hacohen, Sukhvir Wright, Jonathan Gadian, Angela Vincent, Ming Lim, Evangeline Wassmer, Jean-Pierre Lin
Expressive dysphasia and mutism are common clinical features in children and adults with N-methyl-d-aspartate receptor antibodies (NMDAR-Ab) encephalitis, and are likely to result from NMDAR hypofunction. A prodromal loss of social and communication skills can typify that of an autistic regression, particularly when presenting under the age of 3 years. Here we describe two toddlers who presented with developmental regression, particularly of their social communication skills, mimicking an autistic regression, who were found to have NMDAR-Ab in the serum and cerebrospinal fluid...
October 2016: Developmental Medicine and Child Neurology
Yael Hacohen, Yukihiro Nishimoto, Yuki Fukami, Bethan Lang, Patrick Waters, Ming J Lim, Nobuhiro Yuki, Angela Vincent
AIM: Central nervous system (CNS) autoantibodies have been reported in a range of neuroimmune diseases, but there has not been a systematic evaluation of autoantibodies in paediatric patients with brainstem encephalitis. METHOD: Serum samples from 57 children (40 male, 17 female, median age 12y, range 0.6-18y) with a diagnosis of brainstem encephalitis were tested retrospectively for antibodies to GQ1b, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), N-methyl-D-aspartate receptor, LGI1, CASPR2, glycine receptor (GlyR), DPPX, and the voltage gated potassium channel (VGKC)-complex...
August 2016: Developmental Medicine and Child Neurology
Nicholas M Allen, Yael Hacohen, Jacqueline Palace, David Beeson, Angela Vincent, Heinz Jungbluth
No abstract text is available yet for this article.
February 16, 2016: Neurology
Sekhar C Pillai, Shekeeb S Mohammad, Yael Hacohen, Esther Tantsis, Kristina Prelog, Elizabeth H Barnes, Deepak Gill, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale
To define the risk factors for postencephalitic epilepsy (PE) and drug-resistant epilepsy (DRE) in childhood following infectious and autoimmune encephalitis, we included 147 acute encephalitis patients with a median follow-up of 7.3 years (range 2-15.8 years). PE was defined as the use of antiepileptic drugs (AEDs) for ≥24 months, and DRE was defined as the persistence of seizures despite ≥2 appropriate AEDs at final follow-up. PE and DRE were diagnosed in 31 (21%) and 15 (10%) of patients, respectively...
January 2016: Epilepsia
Sanduni Kariyawasam, Rahul R Singh, Jonathan Gadian, Daniel E Lumsden, Jean-Pierre Lin, Ata Siddiqui, Yael Hacohen, Michael Absoud, Ming Lim
OBJECTIVE: To identify clinical and radiological features of children that relapse following an initial presentation of acute disseminated encephalomyelitis (ADEM). METHODS: Clinical records and neuroimaging of children under the age of 16 years presenting with ADEM to a pediatric neurology referral center between 2006 and 2010 were evaluated. RESULTS: Of the 32 children with ADEM, 24 (7 female) with a median age of 4.8 (range 3-15) had a monophasic course...
September 2015: Multiple Sclerosis and related Disorders
Yael Hacohen, Rahul Singh, Meghan Rossi, Bethan Lang, Cheryl Hemingway, Ming Lim, Angela Vincent
OBJECTIVE: To assess the clinical and immunologic findings in children with voltage-gated potassium channel (VGKC)-complex antibodies (Abs). METHODS: Thirty-nine of 363 sera, referred from 2 pediatric centers from 2007 to 2013, had been reported positive (.100 pM) for VGKC-complex Abs. Medical records were reviewed retrospectively and the patients’ condition was independently classified as inflammatory (n 5 159) or noninflammatory (n 5 204). Positive sera (.100 pM) were tested/retested for the VGKC complex Ab–positive complex proteins LGI1 and CASPR2, screened for binding to live hippocampal neurons, and 12 high-titer sera (...
September 15, 2015: Neurology
Susan Byrne, Cathal Walsh, Yael Hacohen, Eyal Muscal, Joseph Jankovic, Amber Stocco, Russell C Dale, Angela Vincent, Ming Lim, Mary King
No abstract text is available yet for this article.
August 2015: Neurology® Neuroimmunology & Neuroinflammation
Alasdair Bamford, Belinda H A Crowe, Yael Hacohen, Jean-Pierre Lin, Antonia Clarke, Gareth Tudor-Williams, Vanessa Sancho-Shimizu, Angela Vincent, Ming Lim, Sunil P Pullaperuma
N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.
June 2015: Journal of the Pediatric Infectious Diseases Society
Yael Hacohen, Sameer Zuberi, Angela Vincent, Yanick J Crow, Nuno Cordeiro
No abstract text is available yet for this article.
July 28, 2015: Neurology
Ming Lim, Yael Hacohen, Angela Vincent
Antibody-mediated diseases of the central nervous system are a relatively new and challenging field in autoimmune neurologic disease and of major clinical importance in children and adults. The antibodies bind to cell-surface epitopes on neuronal or glial proteins, and the patients demonstrate either focal or more generalized clinical signs depending on the extent of brain regions targeted by the antibodies. The presence of seizures, movement disorders, autonomic dysfunction and sleep disorders, alongside neuroimaging and electrophysiological features may indicate a specific antibody-mediated disorder...
June 2015: Pediatric Clinics of North America
Sekhar C Pillai, Yael Hacohen, Esther Tantsis, Kristina Prelog, Vera Merheb, Alison Kesson, Elizabeth Barnes, Deepak Gill, Richard Webster, Manoj Menezes, Simone Ardern-Holmes, Sachin Gupta, Peter Procopis, Christopher Troedson, Jayne Antony, Robert A Ouvrier, Yann Polfrit, Nicholas W S Davies, Patrick Waters, Bethan Lang, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale
BACKGROUND AND OBJECTIVES: Pediatric encephalitis has a wide range of etiologies, clinical presentations, and outcomes. This study seeks to classify and characterize infectious, immune-mediated/autoantibody-associated and unknown forms of encephalitis, including relative frequencies, clinical and radiologic phenotypes, and long-term outcome. METHODS: By using consensus definitions and a retrospective single-center cohort of 164 Australian children, we performed clinical and radiologic phenotyping blinded to etiology and outcomes, and we tested archived acute sera for autoantibodies to N-methyl-D-aspartate receptor, voltage-gated potassium channel complex, and other neuronal antigens...
April 2015: Pediatrics
Yael Hacohen, Michael Absoud, Kumaran Deiva, Cheryl Hemingway, Petra Nytrova, Mark Woodhall, Jacqueline Palace, Evangeline Wassmer, Marc Tardieu, Angela Vincent, Ming Lim, Patrick Waters
OBJECTIVE: To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). METHOD: Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France...
April 2015: Neurology® Neuroimmunology & Neuroinflammation
Yael Hacohen, Leslie W Jacobson, Susan Byrne, Fiona Norwood, Abhimanu Lall, Stephanie Robb, Robertino Dilena, Monica Fumagalli, Alfred Peter Born, Debbie Clarke, Ming Lim, Angela Vincent, Heinz Jungbluth
BACKGROUND: Transient neonatal myasthenia gravis (TNMG) affects a proportion of infants born to mothers with myasthenia gravis (MG). Symptoms usually resolve completely within the first few months of life, but persistent myopathic features have been reported in a few isolated cases. METHODS: Here we report 8 patients from 4 families born to mothers with clinically manifest MG or mothers who were asymptomatic but had elevated acetylcholine receptor (AChR) antibody levels...
February 2015: Neurology® Neuroimmunology & Neuroinflammation
Richard E Rosch, Alasdair Bamford, Yael Hacohen, Elizabeth Wraige, Angela Vincent, Leena Mewasingh, Ming Lim
The pathogenesis of Guillain-Barré syndrome (GBS) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens. Antibodies to contactin-associated protein-like 2 (CASPR2), part of the voltage-gated potassium channel complex (VGKC-complex), are associated with neurological disease predominantly affecting the peripheral nervous system but are not known to be associated with GBS. We report two cases of ganglioside antibody-negative paediatric GBS associated with CASPR2 antibodies...
September 2014: Journal of the Peripheral Nervous System: JPNS
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