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MTA study

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https://www.readbyqxmd.com/read/28210434/effect-of-the-tio2-nanoparticles-on-the-selected-physical-properties-of-mineral-trioxide-aggregate
#1
Mohammad Samiei, Maryam Janani, Naser Asl-Aminabadi, Negin Ghasemi, Baharak Divband, Sajjad Shirazi, Kayvan Kafili
BACKGROUND: Some of the efforts to improve the properties of Mineral Trioxide Aggregate (MTA) include incorporation of some nanoparticles such as Titanium dioxide (TiO2). The aim of this study was to evaluate the effect of TiO2 nanoparticles on the setting time, working time, push-out bond strength and compressive strength of MTA. MATERIAL AND METHODS: The physical properties to be evaluated were determined using the ISO 6786:2001 and 9917 specifications. Fifteen samples of each material (MTA or MTA with 1% weight ratio of TiO2 Nanoparticles) were prepared for any evaluated physical property...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210432/biocompatibility-of-mineral-trioxide-aggregate-with-tio2-nanoparticles-on-human-gingival-fibroblasts
#2
Mohammad Samiei, Negin Ghasemi, Marzieh Aghazadeh, Baharak Divband, Farzaneh Akbarzadeh
BACKGROUND: The New compositions of white mineral trioxide aggregate (WMTA) or use of various additives like nanoparticles might affect MTA's ideal characteristics This study was performed to evaluate the cytotoxicity of WMTA and WMTA with Titanium dioxide (TiO2) nanoparticles (1% weight ratio) at different storage times after mixing on human gingival fibroblasts (HGFs). MATERIAL AND METHODS: HGFs were obtained from the attached gingiva of human premolars. HGFs were cultured in Dulbecco's Modified Eagle medium, supplemented with 10% fetal calf serum, penicillin and streptomycin...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210431/vertical-root-fracture-resistance-of-simulated-immature-permanent-teeth-filled-with-mta-using-different-vehicles
#3
Hacer Aksel, Sevinc Askerbeyli-Örs, Derya Deniz-Sungur
BACKGROUND: The aim of the study is to evaluate the resistance vertical root fracture (VRF) of mineral trioxide aggregate (MTA) filled-immature permanent roots by using three different vehicles. MATERIAL AND METHODS: Forty-extracted human single-rooted mandibular premolars were selected and the root length was standardized to the length of 9 mm. For simulation of immature tooth apices, peeso reamers were introduced into the root canals and the prepared roots were assigned into three experimental groups according the used vehicle (distilled water-DW, prophylene glycol-PG, chlorhexidine-CHX) and control group (n=10)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28203091/expression-of-microrna-30c-via-lentivirus-vector-inhibits-the-proliferation-and-enhances-the-sensitivity-of-highly-aggressive-ccrcc-caki-1-cells-to-anticancer-agents
#4
Honglin Yang, Erlin Song, Guorong Shen, Tonghua Zhu, Tingwang Jiang, Hao Shen, Liping Niu, Biao Wang, Zhaoyang Lu, Jianping Qian
The clear cell renal cell carcinoma (ccRCC) is one of the most fatal urologic tumors, and the prognosis remains very poor for advanced or metastatic ccRCC. This study reveals the roles of microRNA (miR)-30c in regulating a highly aggressive ccRCC cell line proliferation by targeting MTA-1, which is a key mediator for human cancer metastasis. Results from quantitative real-time polymerase chain reaction showed that the expression of MTA-1, the target of miR-30c, was significantly higher in metastatic ccRCC specimens than in nonmetastatic ccRCC or nontumor specimens...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28190811/histological-evaluation-of-direct-pulp-capping-with-all-in-one-adhesives-in-rat-teeth
#5
Koichi Shinkai, Yoshihisa Taira, Satoki Kawashima, Shiro Suzuki, Masaya Suzuki
The aim of this study was to histologically evaluate direct pulp capping using different all-in-one adhesives in rat teeth. Five all-in-one adhesives and a control material (MTA) were used. Each material was applied on the exposed pulp, and each cavity was subsequently restored with the resin composite. Rats were sacrificed 14 days after the surgical procedure. Serial stained sections were histologically evaluated for examining pulp tissue disorganization (PTD), inflammatory cell infiltration (ICI), dentin bridge formation (DBF), and bacterial penetration (BP)...
February 11, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28184981/association-mapping-utilizing-diverse-barley-lines-reveals-net-form-net-blotch-seedling-resistance-susceptibility-loci
#6
Jonathan K Richards, Timothy L Friesen, Robert S Brueggeman
A diverse collection of barley lines was phenotyped with three North American Pyrenophora teres f. teres isolates and association analyses detected 78 significant marker-trait associations at 16 genomic loci. Pyrenophora teres f. teres is a necrotrophic fungal pathogen and the causal agent of the economically important foliar disease net form net blotch (NFNB) of barley. The deployment of effective and durable resistance against P. teres f. teres has been hindered by the complexity of quantitative resistance and susceptibility...
February 9, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28182250/determinants-of-the-recommended-phase-2-dose-of-molecular-targeted-agents
#7
Aaron R Hansen, Natalie Cook, Eitan Amir, Lillian L Siu, Albiruni Ryan Abdul Razak
BACKGROUND: The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose-limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be relevant to molecularly targeted agents (MTAs). METHODS: A systematic review identified all monotherapy phase 1 studies of MTAs in solid tumors published between 2001 and 2013. Dose, dosing schedule, and determinants of RP2D were collected from each study...
February 9, 2017: Cancer
https://www.readbyqxmd.com/read/28179935/shear-bond-strength-of-self-adhering-flowable-composite-and-resin-modified-glass-ionomer-to-two-pulp-capping-materials
#8
Maryam Doozaneh, Fatemeh Koohpeima, Maryam Firouzmandi, Forugh Abbassiyan
INTRODUCTION: The aim of this study was to compare the shear bond strength of a self-adhering flowable composite (SAFC) and resin-modified glass ionomer (RMGI) to mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement. METHODS AND MATERIALS: A total of 72 acrylic blocks with a central hole (4 mm in diameter and 2 mm in depth) were prepared. The holes were filled with MTA (sub group A) and CEM cement. The specimens of both restorative materials were divided into 6 groups; overall there were 12 groups...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28179934/antifungal-activity-of-two-root-canal-sealers-against-different-strains-of-candida
#9
Farnaz Jafari, Sanaz Jafari, Hossein Samadi Kafil, Tahereh Momeni, Helen Jamloo
INTRODUCTION: Microorganisms and microbial products are the main etiologic factors in pulp and periapical diseases. The present study aimed to compare the antifungal activity of two different sealers, AH-26 and MTA Fillapex against three strains of Candida, 24, 48, 72 h and 7 days after mixing. METHODS AND MATERIALS: The microorganisms used in this study were Candidia albicans (ATCC 10231), Candidia glabrata (ATCC 90030) and Candidia krusei (DSM 70079). This test was based on growth of microorganisms and turbidity measurement technique using a spectrophotometer...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28179916/postoperative-pain-following-pulpotomy-of-primary-molars-with-two-biomaterials-a-randomized-split-mouth-clinical-trial
#10
Leili Shafie, Hamide Barghi, Masoud Parirokh, Hamed Ebrahimnejad, Nozar Nakhae, Sara Esmaili
INTRODUCTION: The aim of this randomized clinical trial split-mouth study was to compare the postoperative pain following use of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement as pulpotomy agents in carious primary molars. METHODS AND MATERIALS: Forty-seven children aged between 6-10 years old were enrolled in this study. Each child had two cariously involved primary molar in need of pulpotomy. After caries removal and preparing access cavity in one of the carious teeth, either MTA or CEM cement was randomly used as the pulpotomy agent, while the other cariously involved primary molar tooth was capped with the other material in a separate visit...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28179136/expression-purification-and-characterization-of-the-human-mta2-rbbp7-complex
#11
Christoffer Brasen, Jerzy Dorosz, Anders Wiuf, Thomas Boesen, Osman Mirza, Michael Gajhede
The repressive Nucleosome Remodeling and histone Deacetylation (NuRD) complex remodels the chromatin structure by coupling ATP-dependent remodeling activity with histone deacetylase function and plays important roles in regulating gene transcription, DNA damage repair and chromatin assembly. The complex is composed of six subunits: Metastasis Associated proteins MTA1/2/3 initially recruit histone chaperones RBBP4/7 followed by the histone deacetylases HDAC1/2 forming a core complex. Further association of the CpG-binding protein MBD2/3, p66α/β and the ATP-dependent helicase CDH3/4 constitutes the NuRD complex...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28169432/cytotoxicity-and-bioactivity-of-various-pulpotomy-materials-on-stem-cells-from-human-exfoliated-primary-teeth
#12
M Collado-González, D García-Bernal, R E Oñate-Sánchez, P S Ortolani-Seltenerich, T Álvarez Muro, A Lozano, L Forner, C Llena, J M Moraleda, F J Rodríguez-Lozano
AIMS: To investigate the cytotoxicity and bioactivity of several pulpotomy materials: Biodentine (Septodont, Saint- Maur-des-Fosses, France) MTA (Angelus, Londrina, PR, Brazil), Theracal LC (Bisco Inc., Schamburg, IL, USA) and IRM (Dentsply DeTrey GmbH, Konstanz, Germany), after contact with stem cells isolated from human exfoliated deciduous teeth (SHEDs). METHODOLOGY: SHEDs were cultured in the presence of the eluates of various pulpotomy materials for 24, 48 and 72h...
February 7, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28166690/how-substance-users-with-adhd-perceive-the-relationship-between-substance-use-and-emotional-functioning
#13
John T Mitchell, Thomas S Weisner, Peter S Jensen, Desiree W Murray, Brooke S G Molina, Eugene L Arnold, Lily Hechtman, James M Swanson, Stephen P Hinshaw, Elizabeth C Victor, Scott H Kollins, Karen C Wells, Katherine A Belendiuk, Andrew Blonde, Celeste Nguyen, Lizeth Ambriz, Jenny L Nguyen
OBJECTIVE: Although substance use (SU) is elevated in ADHD and both are associated with disrupted emotional functioning, little is known about how emotions and SU interact in ADHD. We used a mixed qualitative-quantitative approach to explore this relationship. METHOD: Narrative comments were coded for 67 persistent (50 ADHD, 17 local normative comparison group [LNCG]) and 25 desistent (20 ADHD, 5 LNCG) substance users from the Multimodal Treatment Study of Children with ADHD (MTA) adult follow-up (21...
February 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28166468/dose-finding-designs-for-trials-of-molecularly-targeted-agents-and-immunotherapies
#14
Cody Chiuzan, Jonathan Shtaynberger, Gulam A Manji, Jimmy K Duong, Gary K Schwartz, Anastasia Ivanova, Shing M Lee
Recently, there has been a surge of early phase trials of molecularly targeted agents (MTAs) and immunotherapies. These new therapies have different toxicity profiles compared to cytotoxic therapies. MTAs can benefit from new trial designs that allow inclusion of low-grade toxicities, late-onset toxicities, addition of an efficacy endpoint, and flexibility in the specification of a target toxicity probability. To study the degree of adoption of these methods, we conducted a Web of Science search of articles published between 2008 and 2014 that describe phase 1 oncology trials...
February 6, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28149459/sealing-efficacy-of-mineral-trioxide-aggregate-with-and-without-nanosilver-for-root-end-filling-an-in-vitro-bacterial-leakage-study
#15
Mahsa Eskandarinezhad, Naiemeh Shahveghar-Asl, Reza Sharghi, Sajjad Shirazi, Sahar Shakouie, Amin-Salem Milani, Esrafil Balaei
BACKGROUND: Various materials have been added to mineral trioxide aggregate to enhance its properties. This study was aimed to compare the sealing efficacy of MTA with and without nanosilver using bacterial leakage approach. MATERIAL AND METHODS: Seventy canine teeth were prepared and obturated. Then, after apical resection, the root-end cavities were prepared by ultrasonic retrotips. Teeth were randomly divided into 4 groups containing two experimental groups (n=30) and two negative and positive controls (n=5)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28132710/treatment-outcomes-of-apexification-or-revascularization-in-nonvital-immature-permanent-teeth-a-retrospective-study
#16
Jidapa Silujjai, Pairoj Linsuwanont
INTRODUCTION: The purposes of this retrospective study were to evaluate the clinical and radiographic outcomes of mineral trioxide aggregate apexification and revascularization in nonvital immature permanent teeth and to analyze factors influencing treatment outcome. METHODS: Forty-six cases (29 cases of apexification and 17 cases of revascularization) were recruited into this study. Patients' preoperative and postoperative information was analyzed. Treatment outcomes were categorized as a success or failure and functional retention...
February 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28128328/antimicrobial-activity-of-proroot-mta-in-contact-with-blood
#17
C Farrugia, P Baca, J Camilleri, M T Arias Moliz
Dental materials based on Portland cement, which is used in the construction industry have gained popularity for clinical use due to their hydraulic properties, the interaction with tooth tissue and their antimicrobial properties. The antimicrobial properties are optimal in vitro. However in clinical use contact with blood may affect the antimicrobial properties. This study aims to assess whether antimicrobial properties of the Portland cement-based dental cements such as mineral trioxide aggregate (MTA) are also affected by contact with blood present in clinical situations...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060554/current-molecular-and-genetic-aspects-of-pancreatic-cancer-the-role-of-metastasis-associated-proteins-mta-a-review
#18
Efstathios T Pavlidis, Theodoros E Pavlidis
: Purpose/aim: To focus on current molecular and genetic aspects and MTA proteins, since pancreatic cancer is a lethal malignant with poor prognosis. Early diagnosis is essential step, contributing to potential curative resection. MATERIALS AND METHODS: A PubMed search of relevant articles published up to August 2016 was performed to identify current information about pancreatic cancer regarding molecular biomarkers, with emphasis on carcinogenesis, novel therapeutic targets, and MTA proteins...
January 6, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28060180/new-single-stage-double-osteotomy-for-late-presenting-infantile-tibia-vara-a-comprehensive-approach
#19
Edward Abraham, David Toby, Michelle Welborn, Cory W Helder, Angela Murphy
BACKGROUND: Successful surgical treatment of late-presenting infantile tibia vara (ITV) patient requires the correction of oblique deformities. The purpose of this study was to report on a new comprehensive approach to correct and prevent recurrence of these deformities with a single procedure. METHODS: Medical records of 23 consecutive children (7 to 18 y) with advanced ITV (29 knees) were retrospectively reviewed after a mean of 7.3 years postoperatively (range, 2 to 22 y)...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28045315/composition-and-microstructure-of-mta-and-aureoseal-plus-xrf-eds-xrd-and-fesem-evaluation
#20
L Cianconi, P Palopoli, V Campanella, M Mancini
AIM: The aim of this study was to determine the chemical composition and the phases' microstructure of Aureoseal Plus (OGNA, Italy) and ProRoot MTA (Dentsply Tulsa Dental, USA) and to compare their characteristics. MATERIALS AND METHODS: Study Design: Comparing Aureoseal Plus and ProRoot MTA microstructure by means of several analyses type. The chemical analysis of the two cements was assessed following the UNI EN ISO 196-2 norm. X-Ray fluorescence (XRF) was used to determine the element composition...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
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