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https://www.readbyqxmd.com/read/28060554/current-molecular-and-genetic-aspects-of-pancreatic-cancer-the-role-of-metastasis-associated-proteins-mta-a-review
#1
Efstathios T Pavlidis, Theodoros E Pavlidis
: Purpose/aim: To focus on current molecular and genetic aspects and MTA proteins, since pancreatic cancer is a lethal malignant with poor prognosis. Early diagnosis is essential step, contributing to potential curative resection. MATERIALS AND METHODS: A PubMed search of relevant articles published up to August 2016 was performed to identify current information about pancreatic cancer regarding molecular biomarkers, with emphasis on carcinogenesis, novel therapeutic targets, and MTA proteins...
January 6, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28060180/new-single-stage-double-osteotomy-for-late-presenting-infantile-tibia-vara-a-comprehensive-approach
#2
Edward Abraham, David Toby, Michelle Welborn, Cory W Helder, Angela Murphy
BACKGROUND: Successful surgical treatment of late-presenting infantile tibia vara (ITV) patient requires the correction of oblique deformities. The purpose of this study was to report on a new comprehensive approach to correct and prevent recurrence of these deformities with a single procedure. METHODS: Medical records of 23 consecutive children (7 to 18 y) with advanced ITV (29 knees) were retrospectively reviewed after a mean of 7.3 years postoperatively (range, 2 to 22 y)...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28045315/composition-and-microstructure-of-mta-and-aureoseal-plus-xrf-eds-xrd-and-fesem-evaluation
#3
L Cianconi, P Palopoli, V Campanella, M Mancini
AIM: The aim of this study was to determine the chemical composition and the phases' microstructure of Aureoseal Plus (OGNA, Italy) and ProRoot MTA (Dentsply Tulsa Dental, USA) and to compare their characteristics. MATERIALS AND METHODS: Study Design: Comparing Aureoseal Plus and ProRoot MTA microstructure by means of several analyses type. The chemical analysis of the two cements was assessed following the UNI EN ISO 196-2 norm. X-Ray fluorescence (XRF) was used to determine the element composition...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043847/nanoscale-chemical-surface-characterization-of-four-different-types-of-dental-pulp-capping-materials
#4
Victor Gong, Rodrigo França
OBJECTIVES: The surface of any dental pulp-capping material has important implications for its clinical success because it is in direct contact with dental tissue, which influences its cytotoxicity. The aim was to determine the chemical composition of the first atomic layers of four pulp-protection agents because these atoms can initiate the pulp healing process. METHODS: Biodentine (Septodont), ProRoot MTA (Dentsply), Dycal (Caulk) and TheraCal (Bisco) were prepared (n=5) according to manufacturer recommendations...
December 30, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/28043087/long-term-treatment-outcomes-in-immature-permanent-teeth-by-revascularisation-using-mta-and-gic-as-canal-sealing-materials-a-retrospective-study
#5
Chufang Peng, Yuan Yang, Yuming Zhao, He Liu, Zheng Xu, Dianhong Zhao, Man Qin
BACKGROUND: Pulp revascularisation with MTA sealing has been accepted as an alternative treatment for non-vital immature permanent teeth. Successful revascularisation cases with GIC sealing were also reported, but lack of long-term researches. AIM: To evaluate long-term outcomes of revascularisation using MTA and GIC as canal-sealing materials in non-vital immature permanent teeth. DESIGN: Clinical and radiographic data of 60 non-vital immature permanent teeth treated with revascularisation (36...
January 2, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28041685/treatment-outcomes-of-mineral-trioxide-aggregate-pulpotomy-in-vital-permanent-teeth-with-carious-pulp-exposure-the-retrospective-study
#6
Pairoj Linsuwanont, Kongthum Wimonsutthikul, Uht Pothimoke, Busayarat Santiwong
INTRODUCTION: This study aimed to illustrate the treatment outcomes of mineral trioxide aggregate (MTA) pulpotomy in vital permanent teeth with carious pulp exposure. METHODS: MTA pulpotomy was performed in 66 vital permanent teeth with carious pulp exposure including teeth with signs and symptoms of irreversible pulpitis and the presence of periapical radiolucency. Patients were assessed for clinical and radiographic outcomes by 2 examiners. The relationship between treatment outcomes and factors was analyzed by means of univariate analysis and binary logistic regression...
December 29, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28032041/in-vitro-and-ex-vivo-microbial-leakage-assessment-in-endodontics-a-literature-review
#7
REVIEW
Sohrab Tour Savadkouhi, Hengameh Bakhtiar, Safoura Emami Ardestani
The aim of this study was to perform a literature review of published in-vitro and ex-vivo studies, which evaluated microbial leakage in endodontics in the past 10 years. A comprehensive electronic literature search was carried out in PubMed database for English articles published from 2005 to 2016 using the keywords "endodontics," "in vitro," "ex vivo," "microbial leakage," "microbial penetration," "saliva," "Enterococcus faecalis," "E. faecalis," "endodontic sealers," "temporary filling material," "apical plug," "mineral trioxide aggregate," and "MTA...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28030582/therapeutic-targeting-of-the-mitochondria-initiates-excessive-superoxide-production-and-mitochondrial-depolarization-causing-decreased-mtdna-integrity
#8
Kaytee L Pokrzywinski, Thomas G Biel, Dmitry Kryndushkin, V Ashutosh Rao
Mitochondrial dysregulation is closely associated with excessive reactive oxygen species (ROS) production. Altered redox homeostasis has been implicated in the onset of several diseases including cancer. Mitochondrial DNA (mtDNA) and proteins are particularly sensitive to ROS as they are in close proximity to the respiratory chain (RC). Mitoquinone (MitoQ), a mitochondria-targeted redox agent, selectively damages breast cancer cells possibly through damage induced via enhanced ROS production. However, the effects of MitoQ and other triphenylphosphonium (TPP+) conjugated agents on cancer mitochondrial homeostasis remain unknown...
2016: PloS One
https://www.readbyqxmd.com/read/28026167/heat-capacity-changes-for-transition-state-analogue-binding-and-catalysis-with-human-5-methylthioadenosine-phosphorylase
#9
Ross S Firestone, Scott A Cameron, Jerome M Karp, Vickery L Arcus, Vern L Schramm
Human 5'-methylthioadenosine phosphorylase (MTAP) catalyzes the phosphorolysis of 5'-methylthioadenosine (MTA). Its action regulates cellular MTA and links polyamine synthesis to S-adenosylmethionine (AdoMet) salvage. Transition state analogues with picomolar dissociation constants bind to MTAP in an entropically driven process at physiological temperatures, suggesting increased hydrophobic character or dynamic structure for the complexes. Inhibitor binding exhibits a negative heat capacity change (-ΔCp), and thus the changes in enthalpy and entropy upon binding are strongly temperature-dependent...
December 27, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/28004936/computational-study-of-the-degradation-of-s-adenosyl-methionine-in-water
#10
Timm Lankau, Tzu Nung Kuo, Chin Hui Yu
The degradation of S-adenosyl methionine (SAM) to homoserine-γ-lactone (HSL) and methyltioadenine (MTA) in water is studied with MD simulations. The AM1 Hamiltonian is used for the quantum part and the flexible AMBER force field for the H2O molecules. The MD simulations predict the free energy barrier for the degradation reaction to be between 109 and 112 kJ mol(-1) and an overall gain in free energy of -26 kJ mol(-1). The high barrier and the low energy gain of this reaction can be linked to interactions among the carboxylate group of the SAM molecule and solvent H2O molecules, which are not observed on the product side...
January 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28000038/management-of-pulps-exposed-during-carious-tissue-removal-in-adults-a-multi-national-questionnaire-based-survey
#11
Lina Stangvaltaite, Falk Schwendicke, Christopher Holmgren, Marion Finet, Marisa Maltz, Karim Elhennawy, Eero Kerosuo, Sophie Doméjean
OBJECTIVES: The aim of the present study was to investigate and compare the management of pulps exposed during carious tissue removal by French, German, and Norwegian general dental practitioners (GDPs). We further aimed to assess possible dentist- and patient-related factors associated with these management decisions. MATERIALS AND METHODS: A structured questionnaire was send via mail to a simple random sample of dentists. RESULTS: The analyzed sample consisted of 661 (33%) French GDPs, 622 (25%) German GDPs, and 199 (34%) Norwegian GDPs...
December 20, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27995139/carious-exposure-versus-mechanical-exposure-for-mta-pulpotomy-in-primary-teeth
#12
Burcu Nihan Çelik, Şaziye Sarı
Introduction. The etiology of exposure determines pulpal response, making it crucial to distinguish between mechanical and carious exposure. This study clinically and radiographically evaluated the success of MTA pulpotomies conducted to treat carious and mechanical pulp exposure. Materials and Methods. This study was conducted with 50 mandibular primary molar teeth. Teeth were divided into 2 groups according to status of the exposure site, with teeth surrounded by carious dentin placed in a carious exposure group and those surrounded by sound dentin in a mechanical exposure group...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27995073/distinct-effects-of-childhood-adhd-and-cannabis-use-on-brain-functional-architecture-in-young-adults
#13
Clare Kelly, F Xavier Castellanos, Olivia Tomaselli, Krista Lisdahl, Leanne Tamm, Terry Jernigan, Erik Newman, Jeffery N Epstein, Brooke S G Molina, Laurence L Greenhill, Steven G Potkin, Stephen Hinshaw, James M Swanson
One of the most salient long-term implications of a childhood diagnosis of ADHD is an increased risk for substance use, abuse, or dependence in adolescence and adulthood. The extent to which cannabis use affects ADHD-related alterations in brain functional organization is unknown, however. To address this research gap, we recruited a sample of 75 individuals aged 21-25 years with and without a childhood diagnosis of ADHD Combined Type, who were either frequent users or non-users of cannabis. These participants have been followed longitudinally since age 7-9...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27994420/comparative-evaluation-of-platelet-rich-fibrin-mineral-trioxide-aggregate-and-calcium-hydroxide-as-pulpotomy-agents-in-permanent-molars-with-irreversible-pulpitis-a-randomized-controlled-trial
#14
Varun Kumar, Ruchi Juneja, Jigyasa Duhan, Pankaj Sangwan, Sanjay Tewari
BACKGROUND: Pulpotomy has been proposed as an alternative for the management of irreversible pulpitis in permanent molars with closed apices. AIM: To compare the performances of calcium hydroxide (CH), mineral trioxide aggregate (MTA), and platelet-rich fibrin (PRF) as pulpotomy agents in mature permanent molars with irreversible pulpitis. MATERIALS AND METHODS: Fifty-four permanent mandibular molars with carious exposure and symptoms of irreversible pulpitis were randomly allocated to three groups, and full pulpotomy was performed using CH, MTA, or PRF as pulpotomy agents...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27994416/sealing-ability-of-mineral-trioxide-aggregate-plus%C3%A2-and-biodentine%C3%A2-for-repair-of-furcal-perforation-in-primary-molars-an-in-vitro-study
#15
Farhin A Katge, Pooja Ravindra Shivasharan, Devendra Patil
BACKGROUND: One of the unfavorable outcomes of endodontic treatment in primary molars is furcal perforation. During treatment, bacterial infection at the site of perforation should be prevented for better prognosis. AIM: This study aims to compare sealing ability of mineral trioxide aggregate (MTA) Plus™ and Biodentine™ for the repair of furcal perforation in primary molars using spectrophotometry. MATERIALS AND METHODS: Access opening was done for all ninety extracted teeth...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27994321/comparison-of-the-antimicrobial-activity-of-direct-pulp-capping-materials-mineral-trioxide-aggregate-angelus-and-biodentine
#16
Taha Özyürek, Ebru Özsezer Demiryürek
PURPOSE: To compare the antimicrobial activity of the tricalcium silicate-based Biodentine (BD) and mineral trioxide aggregate (MTA)-Angelus cement with the aid of agar diffusion test. MATERIALS AND METHODS: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecium were inoculated in the Brucella liquid medium and were incubated at 37°C for 24 h. Thereafter, 100 >μl of the liquid culture of bacteria inoculated in the Mueller-Hinton agar with spread plate technique...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27994315/histological-evaluation-of-mineral-trioxide-aggregate-and-enamel-matrix-derivative-combination-in-direct-pulp-capping-an-in-vivo-study
#17
Indira Priyadarshini Bollu, L Deepa Velagula, Nagesh Bolla, K Kiran Kumar, Archana Hari, Jayaprakash Thumu
AIM: The aim of this study is to evaluate the response of human pulp tissue to mineral trioxide aggregate (MTA), Emdogain (EMD), and combination of MTA/EMD. MATERIALS AND METHODS: This study was performed on sixty intact first and second premolars of human maxillary and mandibular teeth. A standard pulpal exposure was done on all the teeth and was divided into three groups of twenty teeth each and was capped with MTA, EMD, and MTA/EMD combination. The final restoration was done with resin-modified glass ionomer cement...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27994312/cytotoxicity-of-two-available-mineral-trioxide-aggregate-cements-and-a-new-formulation-on-human-gingival-fibroblasts
#18
Maryam Torshabi, Reza Amid, Mahdi Kadkhodazadeh, Sara Eslami Shahrbabaki, Fahimeh S Tabatabaei
AIM: The purpose of this study was to investigate the cytotoxicity of nanohybrid mineral trioxide aggregate (MTA) in comparison with calcium-enriched mixture (CEM) cement and MTA-Angelus, using human gingival fibroblasts (HGFs). MATERIALS AND METHODS: Nine disc-shaped specimens of each material (in 2 set stat: A, set for 24 h; B, set for 30 min; and C, fresh stat) were prepared. HGFs were exposed to tested materials' extracts or control media. Cytotoxicity testing was performed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay in two time intervals...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27993804/randomized-phase-ii-trial-comparing-molecularly-targeted-therapy-based-on-tumor-molecular-profiling-versus-conventional-therapy-in-patients-with-refractory-cancer-cross-over-analysis-from-the-shiva-trial
#19
L Belin, M Kamal, C Mauborgne, C Plancher, F Mulot, Jean-P Delord, A Gonçalves, C Gavoille, C Dubot, N Isambert, M Campone, O Trédan, F Ricci, M Alt, D Loirat, M-P Sablin, X Paoletti, V Servois, C Le Tourneau
BACKGROUND: Several studies used the ratio of progression-free survival (PFS) on genotype-matched treatment to PFS on genotype-unmatched treatment to assess the efficacy of therapy guided by patients' tumor molecular profiling. We evaluated the PFS ratio from patients who cross-oved in the SHIVA trial. PATIENTS AND METHODS: The primary end point of the SHIVA trial was to compare PFS on molecularly targeted agents (MTAs) based on tumor molecular profiling and treatment at physician's choice (TPC) in patients with any kind of cancer who had failed standard-of-care therapy...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27991646/materials-for-retrograde-filling-in-root-canal-therapy
#20
REVIEW
Xiangyu Ma, Chunjie Li, Liuhe Jia, Yan Wang, Wenwen Liu, Xuedong Zhou, Trevor M Johnson, Dingming Huang
BACKGROUND: Root canal therapy is a sequence of treatments involving root canal cleaning, shaping, decontamination and obturation. It is conventionally performed through a hole drilled into the crown of the affected tooth, namely orthograde root canal therapy. For teeth that cannot be treated with orthograde root canal therapy, or for which it has failed, retrograde root filling, which seals the root canal from the root apex, is a good alternative. Many materials, such as amalgam, zinc oxide eugenol and mineral trioxide aggregate (MTA), are generally used...
December 17, 2016: Cochrane Database of Systematic Reviews
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