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https://www.readbyqxmd.com/read/27914769/clinicopathological-and-molecular-characteristics-of-ku-70-80-expression-in-nigerian-breast-cancer-and-its-potential-therapeutic-implications
#1
Ayodeji O J Agboola, Henry O Ebili, Victoria O Iyawe, Adekunbiola A F Banjo, Babatunde A Salami, Emad A Rakha, Chrstopher C Nolan, Ian O Ellis, Andrew R Green
Ku 70/80 is a regulator of the Non-Homologous End Joining (NHEJ) roles in clinicopathological features, and has prognostic significance in breast cancer (BC) in Caucasian populations. However, its significance in the Nigerian BC population, which is characterized by a higher rate of the triple-negative and basal phenotype, p53 mutation rate and BRCA1 deficiency, still needs to be investigated. We hypothesize that Ku70/80 expression shows adverse expression in Nigerian BC and, furthermore, that it is likely to have a therapeutic implication for Black BC management...
October 25, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27895098/brain-aluminium-accumulation-and-oxidative-stress-in-the-presence-of-calcium-silicate-dental-cements
#2
K Demirkaya, B Can Demirdöğen, Z Öncel Torun, O Erdem, E Çırak, Y M Tunca
Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27891629/capping-carious-exposures-in-adults-a-randomized-controlled-trial-investigating-mineral-trioxide-aggregate-versus-calcium-hydroxide
#3
R Kundzina, L Stangvaltaite, H M Eriksen, E Kerosuo
AIM: The aim of this multicentre, parallel-group randomized clinical trial was to compare the effectiveness of mineral trioxide aggregate (MTA) and a conventional calcium hydroxide liner (CH) as direct pulp capping materials in adult molars with carious pulpal exposure. METHODOLOGY: Seventy adults aged 18-55 years were randomly allocated to two parallel arms: MTA (White ProRoot, Dentsply, Tulsa Dental, Tulsa, OK, USA; n = 33) and CH (Dycal(®) , Dentsply DeTrey GmbH, Konstanz, Germany; n = 37)...
November 7, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27857514/the-use-of-bioceramics-in-endodontics-literature-review
#4
REVIEW
Stefan Jitaru, Ioana Hodisan, Lucia Timis, Anamaria Lucian, Marius Bud
BACKGROUND AND AIM: Bioceramics are ceramic compounds obtained both in situ and in vivo, by various chemical processes. Bioceramics exhibit excellent biocompatibility due to their similarity with biological materials, like hydroxyapatite. Bioceramics and multi-substituted hydroxyapatite or similar compounds have the ability to induce a regenerative response in the organism. The aim of this paper is to make a literature review on the main bioceramic materials currently used in endodontics and on their specific characteristics...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27856798/the-synthetic-diazonamide-dz-2384-has-distinct-effects-on-microtubule-curvature-and-dynamics-without-neurotoxicity
#5
Michal Wieczorek, Joseph Tcherkezian, Cynthia Bernier, Andrea E Prota, Sami Chaaban, Yannève Rolland, Claude Godbout, Mark A Hancock, Joseph C Arezzo, Ozhan Ocal, Cecilia Rocha, Natacha Olieric, Anita Hall, Hui Ding, Alexandre Bramoullé, Matthew G Annis, George Zogopoulos, Patrick G Harran, Thomas M Wilkie, Rolf A Brekken, Peter M Siegel, Michel O Steinmetz, Gordon C Shore, Gary J Brouhard, Anne Roulston
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical compound that exhibits potent antitumor activity in models of multiple cancer types. It has an unusually high safety margin and lacks neurotoxicity in rats at effective plasma concentrations. DZ-2384 binds the vinca domain of tubulin in a distinct way, imparting structurally and functionally different effects on microtubule dynamics compared to other vinca-binding compounds...
November 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27843254/success-rate-of-mta-pulpotomy-on-vital-pulp-of-primary-molars-a-3-year-observational-study
#6
REVIEW
Brinda Godhi, Rishi Tyagi
INTRODUCTION: Vital pulp therapy is a major contributor in the preservation of primary dentition after caries affliction. Introduction of mineral trioxide aggregate (MTA) has revolutionized such treatment. AIM: The aim of our study was to evaluate and correlate the effects of MTA clinically and radiographically on pulpotomized primary molars till their exfoliation or extraction followed by histological evaluation. STUDY DESIGN: This is an observational study...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27835915/unveiling-changes-in-the-landscape-of-patient-populations-in-cancer-early-drug-development
#7
REVIEW
Cinta Hierro, Analía Azaro, Guillem Argilés, Elena Elez, Patricia Gómez, Joan Carles, Jordi Rodon
The introduction of new Molecularly Targeted Agents (MTA) has changed the landscape in Early Drug Development (EDD) over the last two decades, leading to an improvement in clinical trial design. Previous Phase 1 (Ph1) studies with cytotoxics focused on safety objectives, only recruiting heavily pre-treated cancer patients, have been left behind. In this review, we will illustrate the slow although unstoppable change that has increasingly been observed in those populations candidate to participate in EDD trials with the advent of MTA...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27812618/interaction-of-dental-pulp-stem-cells-with-biodentine-and-mta-after-exposure-to-different-environments
#8
Anastasia Agrafioti, Vasiliki Taraslia, Vanessa Chrepa, Stefania Lymperi, Panos Panopoulos, Ema Anastasiadou, Evangelos G Kontakiotis
Objective: The aim of the present study was to evaluate and compare the cytotoxic effects of Biodentine and MTA on dental pulp stem cells (DPSCs) and to assess cell viability and adherence after material exposure to an acidic environment. Material and Methods: DPSCs were cultured either alone or in contact with either: Biodentine; MTA set for 1 hour; or MTA set for 24 hours. After 4 and 7 days, cell viability was measured using the MTT assay. Biodentine and MTA were also prepared and packed into standardized bovine dentin disks and divided into three groups according to the storage media (n=6/group): freshly mixed materials without storage medium (Group A); materials stored in saline (Group B); materials stored in citric acid buffered at pH 5...
September 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/27806862/functional-adult-outcomes-16-years-after-childhood-diagnosis-of-attention-deficit-hyperactivity-disorder-mta-results
#9
Lily Hechtman, James M Swanson, Margaret H Sibley, Annamarie Stehli, Elizabeth B Owens, John T Mitchell, L Eugene Arnold, Brooke S G Molina, Stephen P Hinshaw, Peter S Jensen, Howard B Abikoff, Guillermo Perez Algorta, Andrea L Howard, Betsy Hoza, Joy Etcovitch, Sylviane Houssais, Kimberley D Lakes, J Quyen Nichols
OBJECTIVE: To compare educational, occupational, legal, emotional, substance use disorder, and sexual behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA). METHOD: Data were collected 12, 14, and 16 years postbaseline (mean age 24.7 years at 16 years postbaseline) from 476 participants with ADHD diagnosed at age 7 to 9 years, and 241 age- and sex-matched classmates...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27806861/childhood-factors-affecting-persistence-and-desistence-of-attention-deficit-hyperactivity-disorder-symptoms-in-adulthood-results%C3%A2-from%C3%A2-the-mta
#10
Arunima Roy, Lily Hechtman, L Eugene Arnold, Margaret H Sibley, Brooke S G Molina, James M Swanson, Andrea L Howard
OBJECTIVE: To determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood. METHOD: Regression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent-child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27790267/apical-sealing-ability-of-mineral-trioxide-aggregate-intermediate-restorative-material-and-calcium-enriched-mixture-cement-a-bacterial-leakage-study
#11
Shahriar Shahriari, Farhad Faramarzi, Mohammad-Yousef Alikhani, Maryam Farhadian, Seyedeh Sareh Hendi
INTRODUCTION: This in vitro study compared the apical sealing ability of three common root end filling materials namely mineral trioxide aggregate (MTA), intermediate restorative material (IRM) and calcium-enriched mixture (CEM) cement using a bacterial leakage model. METHODS AND MATERIALS: The study was conducted on 83 single-rooted human teeth. Tooth crowns were cut and root canals were prepared using the step-back technique. Apical 3 mm of the roots were cut and a three-mm-deep cavity was prepared using an ultrasonic instrument...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27790266/comparison-of-marginal-adaptation-of-mta-and-cem-cement-apical-plugs-in-three-different-media
#12
Fatemeh Ayatollahi, Mahdi Tabrizizadeh, Fatemeh Zare Bidoki, Reza Ayatollahi, Milad Hazeri Baqdad Abad
INTRODUCTION: The aim of this study was to compare the marginal adaptation of mineral trioxide aggregate (MTA) and calcium-enriched mixture(CEM) cement apical plugs in open apex teeth in dry, blood- and saliva-contaminated canals. METHODS AND MATERIALS: A total of 120 human extracted single-rooted teeth were used. The teeth were decoronated and canals were cleaned and shaped up to #80 K-Files. After simulating open apex condition, samples were randomly divided into two groups (Group 1: MTA plug and group 2 CEM cement plug) and each group was then further divided into 3 subgroups (dry canal, blood- and saliva-contaminated canals)...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27790264/compressive-strength-of-mineral-trioxide-aggregate-with-propylene-glycol
#13
Negin Ghasemi, Saeed Rahimi, Shahriar Shahi, Amin Salem Milani, Yashar Rezaei, Mahnaz Nobakht
INTRODUCTION: The aim of this study was to evaluate the effect of adding propylene glycol (PG) to mineral trioxide aggregate (MTA) liquid with volume ratio of 20% on the compressive strength (CS) of MTA in two time periods (4 and 21 days) after mixing. METHODS AND MATERIALS: Four groups of steel cylinders (n=15) with an internal diameter of 3 and a height of 6 mm were prepared and MTA (groups 1 and 2) and MTA+PG (80% MTA liquid+20% PG) (groups 3 and 4) were placed in to the cylinders...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27790263/the-effect-of-mineral-trioxide-aggregate-mixed-with-chlorhexidine-as-direct-pulp-capping-agent-in-dogs-teeth-a-histologic-study
#14
Hamed Manochehrifar, Masoud Parirokh, Sina Kakooei, Mohammad Mehdi Oloomi, Saeed Asgary, Mohammad Jafar Eghbal, Fatemeh Mashhadi Abbas
INTRODUCTION: The aim of the present investigation was to compare the efficacy of mineral trioxide aggregate (MTA) and 0.2% chlorhexidine (CHX) mixture to pure MTA, as a pulp capping material. METHODS AND MATERIALS: The pulp of 24 lateral incisors and canines from four dogs were exposed and capped either with MTA or MTA+0.2% CHX. After 2 months the animals were sacrificed and the teeth were prepared for histological evaluation in terms of calcified bridge formation, the degree of inflammation and presence of necrosis...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27790256/the-effects-of-various-endodontic-irrigants-on-the-push-out-bond-strength-of-calcium-enriched-mixture-cement-and-mineral-trioxide-aggregate
#15
Safoora Sahebi, Fereshte Sobhnamayan, Sina Naghizade
INTRODUCTION: The aim of this in vitro study was to evaluate the effect of various irrigants on the push-out bond strength of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA). METHODS AND MATERIALS: A total of 140 dentin disks with a thickness of 1.5±0.2 mm and lumen size of 1.3 mm, were randomly divided into 12 groups (n=10) and 4 control groups (n=5). The lumen of disks in groups 1, 2, 3, 7, 8, 9 were filled with CEM and groups 4, 5, 6, 10, 11, 12 were filled with MTA...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27776883/gene-expression-profiling-and-molecular-signaling-of-various-cells-in-response-to-tricalcium-silicate-cements-a-systematic-review
#16
Elanagai Rathinam, Sivaprakash Rajasekharan, Ravi Teja Chitturi, Heidi Declercq, Luc Martens, Peter De Coster
INTRODUCTION: The aim of this study was to present a systematic review investigating the gene expression of various cells (other than dental pulp cells) in response to different variants of tricalcium silicate cements (TSCs). METHODS: A systematic search of the literature was performed by 2 independent reviewers followed by article selection and data extraction. Studies analyzing any cell type except dental pulp stem cells and any variant of tricalcium silicate cement either as the experimental or as the control group were included...
October 21, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27776665/image-quality-of-mean-temporal-arterial-and-mean-temporal-portal-venous-phase-images-calculated-from-low-dose-dynamic-volume-perfusion-ct-datasets-in-patients-with-hepatocellular-carcinoma-and-pancreatic-cancer
#17
X Wang, T Henzler, J Gawlitza, S Diehl, T Wilhelm, S O Schoenberg, Z Y Jin, H D Xue, A Smakic
PURPOSE: Dynamic volume perfusion CT (dVPCT) provides valuable information on tissue perfusion in patients with hepatocellular carcinoma (HCC) and pancreatic cancer. However, currently dVPCT is often performed in addition to conventional CT acquisitions due to the limited morphologic image quality of dose optimized dVPCT protocols. The aim of this study was to prospectively compare objective and subjective image quality, lesion detectability and radiation dose between mean temporal arterial (mTA) and mean temporal portal venous (mTPV) images calculated from low dose dynamic volume perfusion CT (dVPCT) datasets with linearly blended 120-kVp arterial and portal venous datasets in patients with HCC and pancreatic cancer...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27769677/bond-strength-of-self-adhesive-resin-cement-to-different-root-perforation-materials
#18
Stephanie Lemos Martins Sicuro, Marilisa Carneiro Leão Gabardo, Carla Castiglia Gonzaga, Nathaly Dias Morais, Flares Baratto-Filho, Gisele Maria Correr Nolasco, Denise Piotto Leonardi
INTRODUCTION: Different materials have been used for intervening in root perforations. These materials are often in contact with resin cements used for cementation of intraradicular retainers. The aim of this study was to evaluate the bond strength of self-adhesive resin cement to different materials used to treat root perforations (mineral trioxide aggregate [MTA], Portland cement [PORT], and glass ionomer cement [GIC]). METHODS: Four discs (10 × 1 mm) of each material (the MTA, PORT, and GIC groups) were embedded into polyvinyl chloride tubes using acrylic resin, ground, and polished until a flat surface was exposed...
October 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27767114/review-suggests-direct-pulp-capping-with-mta-more-effective-than-calcium-hydroxide
#19
Lakshmi Rasaratnam
Data sourcesPubMed, the Cochrane Library, Embase, and the Web of Knowledge.Study selectionRandomised controlled trials (RCTs) or retrospective non-randomised trials (RNTs) of direct pulp capping in patients comparing mineral trioxide aggregate (MTA) with calcium hydroxide (CH) were considered.Data extraction and synthesisTwo reviewers independently abstracted data. Risk of bias for the RCTs was assessed using the Cochrane risk of bias tool and RNTs were assessed according to the methodological index for non-randomised studies...
September 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27761672/histologic-tissue-response-to-furcation-perforation-repair-using-mineral-trioxide-aggregate-or-dental-pulp-stem-cells-loaded-onto-treated-dentin-matrix-or-tricalcium-phosphate
#20
H Bakhtiar, H Mirzaei, M R Bagheri, N Fani, F Mashhadiabbas, M Baghaban Eslaminejad, D Sharifi, M H Nekoofar, Pmh Dummer
OBJECTIVES: The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs. MATERIAL AND METHODS: DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group...
October 20, 2016: Clinical Oral Investigations
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