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MTA study

Elanagai Rathinam, Sivaprakash Rajasekharan, Ravi Teja Chitturi, Heidi Declercq, Luc Martens, Peter De Coster
INTRODUCTION: The aim of this study was to present a systematic review investigating the gene expression of various cells (other than dental pulp cells) in response to different variants of tricalcium silicate cements (TSCs). METHODS: A systematic search of the literature was performed by 2 independent reviewers followed by article selection and data extraction. Studies analyzing any cell type except dental pulp stem cells and any variant of tricalcium silicate cement either as the experimental or as the control group were included...
October 21, 2016: Journal of Endodontics
X Wang, T Henzler, J Gawlitza, S Diehl, T Wilhelm, S O Schoenberg, Z Y Jin, H D Xue, A Smakic
PURPOSE: Dynamic volume perfusion CT (dVPCT) provides valuable information on tissue perfusion in patients with hepatocellular carcinoma (HCC) and pancreatic cancer. However, currently dVPCT is often performed in addition to conventional CT acquisitions due to the limited morphologic image quality of dose optimized dVPCT protocols. The aim of this study was to prospectively compare objective and subjective image quality, lesion detectability and radiation dose between mean temporal arterial (mTA) and mean temporal portal venous (mTPV) images calculated from low dose dynamic volume perfusion CT (dVPCT) datasets with linearly blended 120-kVp arterial and portal venous datasets in patients with HCC and pancreatic cancer...
November 2016: European Journal of Radiology
Stephanie Lemos Martins Sicuro, Marilisa Carneiro Leão Gabardo, Carla Castiglia Gonzaga, Nathaly Dias Morais, Flares Baratto-Filho, Gisele Maria Correr Nolasco, Denise Piotto Leonardi
INTRODUCTION: Different materials have been used for intervening in root perforations. These materials are often in contact with resin cements used for cementation of intraradicular retainers. The aim of this study was to evaluate the bond strength of self-adhesive resin cement to different materials used to treat root perforations (mineral trioxide aggregate [MTA], Portland cement [PORT], and glass ionomer cement [GIC]). METHODS: Four discs (10 × 1 mm) of each material (the MTA, PORT, and GIC groups) were embedded into polyvinyl chloride tubes using acrylic resin, ground, and polished until a flat surface was exposed...
October 18, 2016: Journal of Endodontics
Lakshmi Rasaratnam
Data sourcesPubMed, the Cochrane Library, Embase, and the Web of Knowledge.Study selectionRandomised controlled trials (RCTs) or retrospective non-randomised trials (RNTs) of direct pulp capping in patients comparing mineral trioxide aggregate (MTA) with calcium hydroxide (CH) were considered.Data extraction and synthesisTwo reviewers independently abstracted data. Risk of bias for the RCTs was assessed using the Cochrane risk of bias tool and RNTs were assessed according to the methodological index for non-randomised studies...
September 2016: Evidence-based Dentistry
H Bakhtiar, H Mirzaei, M R Bagheri, N Fani, F Mashhadiabbas, M Baghaban Eslaminejad, D Sharifi, M H Nekoofar, Pmh Dummer
OBJECTIVES: The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs. MATERIAL AND METHODS: DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group...
October 20, 2016: Clinical Oral Investigations
Massimo Del Fabbro, Stefano Corbella, Patrick Sequeira-Byron, Igor Tsesis, Eyal Rosen, Alessandra Lolato, Silvio Taschieri
BACKGROUND: When primary root canal therapy fails, periapical lesions can be retreated with or without surgery. Root canal retreatment is a non-surgical procedure that involves removal of root canal filling materials from the tooth, followed by cleaning, shaping and obturating of the canals. Root-end resection is a surgical procedure that involves exposure of the periapical lesion through an osteotomy, surgical removal of the lesion, removal of part of the root-end tip, disinfection and, commonly, retrograde sealing or filling of the apical portion of the remaining root canal...
October 19, 2016: Cochrane Database of Systematic Reviews
Mohammad Farhadur Rahman, Anubrata Ghosal, Mohammad Firoz Alam, Ahmad Humayan Kabir
Cadmium (Cd) is an important phytotoxic element causing health hazards. This work investigates whether and how silicon (Si) influences the alleviation of Cd toxicity in field peas at biochemical and molecular level. The addition of Si in Cd-stressed plants noticeably increased growth and development as well as total protein and membrane stability of Cd-stressed plants, suggesting that Si does have critical roles in Cd detoxification in peas. Furthermore, Si supplementation in Cd-stressed plants showed simultaneous significant increase and decrease of Cd and Fe in roots and shoots, respectively, compared with Cd-stressed plants...
October 10, 2016: Ecotoxicology and Environmental Safety
Yan Zhang, Fei Bao, Yan Wang, Zhihong Wu
As two major non-operative methods, physiotherapy and acupuncture have been proved to be safe and effective in osteoarthritis (OA) treatment. However, only a little study focused on functions of both methods on cartilage repairing. The main goal of this research is to prove and compare effectiveness of acupuncture and physiotherapy on OA, and to explore their possible efficacy on cartilage repairing. One hundred knees of 50 participants with knee osteoarthritis (KOA) were randomly divided into acupuncture group and physiotherapy group...
2016: American Journal of Translational Research
Muzaffer Emir Dinçol, Hakan Ozbas, Bulent Yılmaz, Handan Ersev, Selcuk Gokyay, Vakur Olgac
BACKGROUND: Due to the detrimental effect of blood contamination on the physico-chemical properties of mineral trioxide aggregate (MTA), obtaining an effective hemostasis in the surgical crypt during apical surgery is of paramount importance. The purpose of this in vivo study was to analyze the effect of Ankaferd Blood Stopper® (ABS) contamination on the biocompatibility of MTA. METHODS: Forty of 56 Wistar-Albino rats were divided randomly and equally into two groups (MTA and MTA-ABS) according to whether or not a hemostatic agent was used...
October 11, 2016: BMC Oral Health
Charlotte L Hall, John A Taylor, Karen Newell, Laurence Baldwin, Kapil Sayal, Chris Hollis
BACKGROUND: The landmark US Multimodal Treatment of ADHD (MTA) study established the benefits of individualised medication titration and optimisation strategies to improve short- to medium-term outcomes in attention-deficit hyperactivity disorder (ADHD). This individualised medication management approach was subsequently incorporated into the National Institute for Health and Care Excellence (NICE) ADHD Clinical Guidelines (NICE CG78). However, little is known about clinicians' attitudes towards implementing these medication management strategies for ADHD in routine care...
January 2016: BJPsych Open
Anja Baraba, Sonja Pezelj-Ribaric, Marija Roguljić, Ivana Miletic
OBJECTIVE: The aim of this study was to investigate the cytotoxicity of two different bioactive root canal sealers: one based on mineral trioxide aggregate, MTA Fillapex (Angelus, Solucoes Odontologicas, Londrina, PR, Brazil), and the other based on bioceramics, Endosequence BC Sealer (Brasseler, Savannah, Georgia, USA), in culture of mouse L929 fibroblasts. MATERIALS AND METHODS: Mouse fibroblasts (L929), obtained from subcutaneous connective tissue of mouse line C3Hf, were cultivated in plastic culture flasks in an incubator at 37şC, with 5% CO2 and 90% humidity...
March 2016: Acta Stomatologica Croatica
P Schembri Wismayer, C Y K Lung, F Rappa, F Cappello, J Camilleri
Portland cement used in the construction industry improves its properties when wet. Since most dental materials are used in a moist environment, Portland cement has been developed for use in dentistry. The first generation material is mineral trioxide aggregate (MTA), used in surgical procedures, thus in contact with blood. The aim of this study was to compare the setting of MTA in vitro and in vivo in contact with blood by subcutaneous implantation in rats. The tissue reaction to the material was also investigated...
September 29, 2016: Scientific Reports
Babita Niranjan, Nandihalli Devendrappa Shashikiran, Shilpy Singla, Ruchi Thakur, Aashutosh Dubey, Satish Maran
INTRODUCTION: A major objective in restorative dentistry is the control of marginal leakage, which may occur because of dimensional changes or lack of adaptation of restorative material to the cavity preparation. Numerous techniques have been advocated to overcome polymerization shrinkage in composite restorations. AIM AND OBJECTIVES: This study investigated microleakage of three different bases under composite resin in sandwich technique using dye penetration and dentin surface interface using scanning electron microscope (SEM)...
October 2016: Journal of the Indian Society of Pedodontics and Preventive Dentistry
M Collado-González, D García-Bernal, R E Oñate-Sánchez, P S Ortolani-Seltenerich, A Lozano, L Forner, C Llena, F J Rodríguez-Lozano
AIM: To evaluate the biocompatibility of three calcium silicate-based endodontic sealers, Bioroot BC Sealer (Septodont, Saint-Maur-des-Fosses, France), Endoseal MTA (EndoSeal, Maruchi, Seoul, Korea) and Nano Ceramic Sealer (B&L Biotech, Fairfax, VA, USA) (NCS) on human periodontal ligament stem cells (hPDLSCs). METHODOLOGY: hPDLSCs cells were cultured in the presence of various endodontic sealer eluates for 24h. Cell viability was determined using the MTT assay...
September 26, 2016: International Endodontic Journal
Young-Chang Cho, Ye Rang Kim, Ba Reum Kim, Tran The Bach, Sayeon Cho
Thunbergia alata (Acanthaceae) has been used traditionally to treat various inflammatory diseases such as fever, cough and diarrhea in East African countries including Uganda and Kenya. However, systemic studies elucidating the anti-inflammatory effects and precise mechanisms of action of T. alata have not been conducted, to the best of our knowledge. To address these concerns, we explored the anti-inflammatory effects of a methanol extract of T. alata (MTA) in macrophages. Non-cytotoxic concentrations of MTA (≤300 µg/ml) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)‑stimulated RAW 264...
September 21, 2016: International Journal of Molecular Medicine
Kenshi Kimoto, Tsubasa Satoh, Munetaka Iwamura, Koichi Nozaki, Takafumi Horikoshi, Shuichi Suzuki, Masatoshi Kozaki, Keiji Okada
Photoinduced electron transfer was studied in dyads (dyad1 and dyad2) containing triphenylamine (MTA) and naphthalenediimide (MNDI) linked with oligo(phenyleneethynylene) dispersed in rigid polymer matrices of polystyrene (PS), poly(vinyl chloride), and poly(methyl methacrylate). Photoexcitation of these dyads yielded long-lived charge-separated (CS) states involving MTA(+) and MNDI(-). The quantum yields of charge separation in dyad1 and dyad2 were approximately 0.4 and 0.3, respectively, in the polymer matrices...
October 6, 2016: Journal of Physical Chemistry. A
Nessrin A Taha, Rima A Safadi, Manal S Alwedaie
INTRODUCTION: The aim of this study was to evaluate the subcutaneous connective tissue response to EndoSequence root repair paste (Brasseler, Savannah, GA) compared with mineral trioxide aggregate (MTA). METHODS: Thirty-six Wistar rats each received 3 sterile tubes, containing 1 of the tested materials and control. The animals were killed 1, 3 and 6 weeks after implantation. The specimens were evaluated histologically for type of inflammation, intensity and extent of inflammatory cells, foreign body reaction, fibrous capsule thickness, perivascular fragments, calcific deposits and vascular congestion...
October 2016: Journal of Endodontics
Yuan-Ling Lee, Wen-Hsi Wang, Feng-Huie Lin, Chun-Pin Lin
BACKGROUND/PURPOSE: Calcium silicate (CS)-based biomaterials, such as mineral trioxide aggregate (MTA), have become the most popular and convincing material used in restorative endodontic treatments. However, the commercially available CS-based biomaterials all contain different minor additives, which may affect their hydration behaviors and material properties. The purpose of this study was to evaluate the hydration behavior of CS-based biomaterials with/without minor additives. METHODS: A novel CS-based biomaterial with a simplified composition, without mineral oxides as minor additives, was produced...
September 20, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Shahrouz Taranejoo, Mohsen Janmaleki, Mohammad Pachenari, Seyed Morteza Seyedpour, Ramya Chandrasekaran, Wenlong Cheng, Kerry Hourigan
A recent approach to colon cancer therapy is to employ selective drugs with specific extra/intracellular sites of action. Alteration of cytoskeletal protein reorganization and, subsequently, to cellular biomechanical behaviour during cancer progression highly affects the cancer cell progress. Hence, cytoskeleton targeted drugs are an important class of cancer therapy agents. We have studied viscoelastic alteration of the human colon adenocarcinoma cell line, SW48, after treatment with a drug delivery system comprising chitosan as the carrier and albendazole as the microtubule-targeting agent (MTA)...
September 20, 2016: International Journal of Pharmaceutics
Maria T Acosta, James Swanson, Annamarie Stehli, Brooke S G Molina, Ariel F Martinez, Mauricio Arcos-Burgos, Maximilian Muenke
BACKGROUND: ADHD is the most common neuropsychiatric condition affecting individuals of all ages. Long-term outcomes of affected individuals and association with severe comorbidities as SUD or conduct disorders are the main concern. Genetic associations have been extensively described. Multiple studies show that intronic variants harbored in the ADGRL3 (LPHN3) gene are associated with ADHD, especially associated with poor outcomes. METHODS: In this study, we evaluated this association in the Multimodal Treatment Study of children with ADHD (MTA), initiated as a 14-month randomized clinical trial of 579 children diagnosed with DSM-IV ADHD-Combined Type (ADHD-C), that transitioned to a 16-year prospective observational follow-up, and 289 classmates added at the 2-year assessment to serve as a local normative comparison group (LNCG)...
September 2016: Molecular Genetics & Genomic Medicine
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