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MTA study

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https://www.readbyqxmd.com/read/28709123/subclinical-white-matter-lesions-and-medial-temporal-lobe-atrophy-are-associated-with-eeg-slowing-in-a-memory-clinic-cohort
#1
Milica G Kramberger, Katarina Giske, Lena Cavallin, Ingemar Kåreholt, Thomas Andersson, Bengt Winblad, Vesna Jelic
OBJECTIVE: The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population. METHODS: Patients with Alzheimer's disease (AD, n=58), mild cognitive impairment (MCI, n=141), subjective cognitive impairment (SCI, n=194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording...
June 15, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28708217/evaluation-of-calcium-ca2-and-hydroxide-oh-ion-diffusion-rates-of-indirect-pulp-capping-materials
#2
Merve Kurun Aksoy, Firdevs Tulga Oz, Kaan Orhan
INTRODUCTION: The aim of this study was to evaluate and compare the calcium (Ca2+) and hydroxide (OH-) ion release of 4 artificially produced pulp capping materials (MTA, Biodentin, TheraCal LC, Calsimol) used for indirect pulp capping treatment. METHODS: In total, 70 freshly extracted human third molar teeth were used for the study. Cavities of extracted teeth were prepared by round burs. The remaining dentin thickness (1 ± 0.3 mm) tissue was measured by a micrometer and cone beam computerized tomography...
July 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28707807/accuracy-of-computer-assisted-navigation-significant-augmentation-by-facial-recognition-software
#3
Jordan T Glicksman, Christine Reger, Arjun K Parasher, David W Kennedy
BACKGROUND: Over the past 20 years, image guidance navigation has been used with increasing frequency as an adjunct during sinus and skull base surgery. These devices commonly utilize surface registration, where varying pressure of the registration probe and loss of contact with the face during the skin tracing process can lead to registration inaccuracies, and the number of registration points incorporated is necessarily limited. The aim of this study was to evaluate the use of novel facial recognition software for image guidance registration...
July 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28698646/plasma-biomarkers-are-associated-with-agitation-and-regional-brain-atrophy-in-alzheimer-s-disease
#4
Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Jiing-Feng Lirng, Shuu-Jiun Wang, Jong-Ling Fuh
This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer's disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108). The Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and Neuropsychiatric Inventory (NPI) subscales were administered to subjects. Magnetic resonance imaging was performed and medial temporal atrophy (MTA) and posterior atrophy (PA) were assessed visually...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691752/mineral-trioxide-aggregate-improves-healing-response-of-periodontal-tissue-to-injury-in-mice
#5
I Vidovic Zdrilic, I O de Azevedo Queiroz, B G Matthews, J E Gomes-Filho, M Mina, I Kalajzic
BACKGROUND AND OBJECTIVE: Mineral trioxide aggregate (MTA) is a biomaterial used in endodontic procedures as it exerts beneficial effects on regenerative processes. In this study, we evaluate the effect of MTA on healing of periodontal ligament (PDL) and surrounding tissue, following injury, in a transgenic mouse model and on the differentiation of murine mesenchymal progenitor cells in vitro. MATERIAL AND METHODS: We used an inducible Cre-loxP in vivo fate mapping approach to examine the effects of MTA on the contributions of descendants of cells expressing the αSMA-CreERT2 transgene (SMA9(+) ) to the PDL and alveolar bone after experimental injury to the root furcation on the maxillary first molars...
July 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28689827/subacromial-corticosteroid-injections-transiently-decrease-suture-anchor-pullout-strength-biomechanical-studies-in-rats
#6
Oleg Dolkart, Ofir Chechik, Assaf Bivas, Tamar Brosh, Michael Drexler, Zachary Weinerman, Eran Maman
BACKGROUND: Arthroscopic rotator cuff (RC) repair incorporates suture anchors to secure torn RC tendons to the greater tuberosity (GT) bone. RC repair strength depends on the anchor-bone interface and on the quality of the GT. We evaluated the effect of single and multiple corticosteroid injections on the pullout strength of suture anchors. METHODS: Fifty rats were divided into those receiving saline solution injection (control group), a single methylprednisolone acetate (MTA) injection (MTA1 group), or 3 once-weekly MTA injections (MTA3 group)...
July 6, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28688183/evaluation-of-ph-and-calcium-ion-diffusion-from-calcium-hydroxide-pastes-and-mta
#7
María Del M Sáez, Gabriela L López, Diana Atlas, María L de la Casa
The aim of this ex vivo study was to evaluate changes in pH and calcium ion diffusion through root dentin from calcium hydroxide (Ca (OH) 2) and mineral trioxide aggregate (MTA) pastes at 7, 30 and 60 days; and the relationship between pH and ion diffusion. Thirty-two human premolars were used. Crowns were sectioned and root canals instrumented and filled in with the following preparations: 1) Ca(OH) 2 + distilled water (n=7); 2) Ca(OH) 2 + 0.1% chlorhexidine gluconate (n=7); 3) MTA + distilled water (n=7); 4) MTA + 0...
April 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28673494/partial-pulpotomy-in-mature-permanent-teeth-with-clinical-signs-indicative-of-irreversible-pulpitis-a-randomized-clinical-trial
#8
Nessrin A Taha, Mohammad A Khazali
INTRODUCTION: This study aimed to assess the outcome of partial pulpotomy using mineral trioxide aggregate (MTA) compared with calcium hydroxide (CH) in mature cariously exposed permanent molars. METHODS: Fifty permanent molar teeth with carious exposures in 50 patients >20 years old were included. Preoperative pulpal and periapical diagnosis was established based on a history of presenting pain, results of cold testing, and radiographic findings. After informed consent, the tooth was anesthetized, isolated via a dental dam, and disinfected with 5% sodium hypochlorite before caries excavation...
June 30, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28671114/associations-of-caide-dementia-risk-score-with-mri-pib-pet-measures-and%C3%A2-cognition
#9
Ruth Stephen, Yawu Liu, Tiia Ngandu, Juha O Rinne, Nina Kemppainen, Riitta Parkkola, Tiina Laatikainen, Teemu Paajanen, Tuomo Hänninen, Timo Strandberg, Riitta Antikainen, Jaakko Tuomilehto, Sirkka Keinänen Kiukaanniemi, Ritva Vanninen, Seppo Helisalmi, Esko Levälahti, Miia Kivipelto, Hilkka Soininen, Alina Solomon
BACKGROUND: CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile. OBJECTIVES: This observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden evaluated with PIB-PET, and detailed cognition measures. METHODS: FINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous national surveys (mean age 52...
June 27, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28665105/characterization-of-a-novel-drosophila-sert-mutant-insights-on-the-contribution-of-the-serotonin-neural-system-to-behaviors
#10
Sergio Hidalgo, Daniela Molina-Mateo, Pía Escobedo, Rafaella V Zarate, Elsa Fritz, Angélica Fierro, Edwin G Pérez, Patricio Iturriaga-Vasquez, Miguel Reyes-Parada, Rodrigo Varas, Nicolás Fuenzalida-Uribe, Jorge M Campusano
A better comprehension on how different molecular components of the serotonergic system contribute to the adequate regulation of behaviors in animals is essential in the interpretation on how they are involved in neuropsychiatric and pathological disorders. It is possible to study these components in "simpler" animal models including the fly Drosophila melanogaster, given that most of the components of the serotonergic system are conserved between vertebrates and invertebrates. Here we decided to advance our understanding on how the serotonin plasma membrane transporter (SERT) contributes to serotonergic neurotransmission and behaviors in Drosophila...
June 30, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28663594/metabolite-profiling-in-identifying-metabolic-biomarkers-in-older-people-with-late-onset-type-2-diabetes-mellitus
#11
Zhi Yang Tam, Sean Pin Ng, Ling Qiao Tan, Chih-Hsien Lin, Dietrich Rothenbacher, Jochen Klenk, Bernhard Otto Boehm
Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in all age groups. T2D in older adults is associated with higher mortality and reduced functional status, leading to higher rate of institutionalization. Despite the potential healthcare challenges associated with the presence of T2D in the elderly, the pathogenesis and phenotype of late-onset T2D is not well studied...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28650994/abnormal-global-functional-network-connectivity-and-its-relationship-to-medial-temporal-atrophy-in-patients-with-amnestic-mild-cognitive-impairment
#12
Can Sheng, Mingrui Xia, Haikuo Yu, Yue Huang, Yan Lu, Fang Liu, Yong He, Ying Han
BACKGROUND: Amnestic mild cognitive impairment (aMCI), which is recently considered as a high risk status for developing Alzheimer's disease (AD), manifests with gray matter atrophy and increased focal functional activity in the medial temporal lobe (MTL). However, the abnormalities of whole-brain functional network connectivity in aMCI and its relationship to medial temporal atrophy (MTA) remain unknown. METHODS: In this study, thirty-six aMCI patients and thirty-five healthy controls (HCs) were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28645857/exploring-the-effect-of-end-binding-proteins-and-microtubule-targeting-chemotherapy-drugs-on-microtubule-dynamic-instability
#13
Diana White, Stéphane Honoré, Florence Hubert
Microtubules (MTs) play a key role in normal cell development and are a primary target for many cancer chemotherapy MT targeting agents (MTAs). As such, understanding MT dynamics in the presence of such agents, as well as other proteins that alter MT dynamics, is extremely important. In general, MTs grow relatively slowly and shorten very fast (almost instantaneously), an event referred to as a catastrophe. These dynamics, referred to as dynamic instability, have been studied in both experimental and theoretical settings...
June 20, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28643130/retreatability-of-three-calcium-silicate-containing-sealers-and-one-epoxy-resin-based-root-canal-sealer-with-four-different-root-canal-instruments
#14
David Donnermeyer, Clarissa Bunne, Edgar Schäfer, Till Dammaschke
OBJECTIVES: The objective of the study was to compare the retreatability of three calcium silicate-containing sealers (BioRoot RCS, MTA Fillapex, Endo C.P.M.) and an epoxy resin-based sealer (AH Plus) with different root canal instruments (Hedström files, Reciproc R40, Mtwo retreatment file R 25/.05 + Mtwo 40/.06, and F6 SkyTaper) concerning sealer remnants and retreatment time. MATERIALS AND METHODS: Root canals of 192 teeth were instrumented with Reciproc R40...
June 22, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28642908/methodologies-for-measuring-the-setting-times-of-mineral-trioxide-aggregate-and-portland-cement-products-used-in-dentistry
#15
William Nguyen Ha, Timothy Nicholson, Bill Kahler, Laurence James Walsh
Objective The current standard used to measure setting time for Mineral Trioxide Aggregate (MTA) involves indentation testing with arbitrary weights. This study compared indentation testing against rheological measurements and assessed the influences of particle size and the inclusion of bismuth oxide on the setting time of experimental MTA and Portland cement (PC). Material and methods Two PCs (P1 and P2) of different particle sizes were produced using the same clinker. From these two PCs, two experimental MTAs (M1 and M2) were created with the addition of bismuth oxide...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28638556/effects-of-different-powder-to-liquid-ratios-on-the-push-out-bond-strength-of-cem-cement-on-simulated-perforations-in-the-furcal-area
#16
Mohammad-Frough Reyhani, Negin Ghasemi, Vahid Zand, Saba Mosavizadeh
BACKGROUND: Proper bond strength to dentin is one of the properties of biomaterials used for therapeutic purposes such as repair of furcal perforations. The aim of the present study to evaluate the effects of different powder to liquid ratios of Calcium-enriched mixture (CEM) on the push-out bond strengths in simulated perforations in the furcal area and compare it with Mineral trioxide aggregate (MTA). MATERIAL AND METHODS: Furcal perforations, measuring 1.3 mm in diameter and 2 mm in height, were prepared in 120 mandibular first molars...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28638549/antibacterial-activity-of-different-root-canal-sealers-against-enterococcus-faecalis
#17
Claudio Poggio, Federico Trovati, Matteo Ceci, Marco Colombo, Giampiero Pietrocola
BACKGROUND: The aim of the present study was to compare in vitro the antimicrobial activity of different root canal sealers against Enterococcus faecalis, prior and subsequent to setting. MATERIAL AND METHODS: Agar diffusion test (ADT) was used for evaluating the antibacterial activity of non-set sealer while the direct contact test (DCT) was used for after setting. RESULTS: ADT: Except for TotalFill BC Sealer all the others sealers tested showed antibacterial activity...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28635511/the-immunohistochemical-expression-mta-1-protein-and-its-prognostic-value-in-pancreatic-cancer
#18
Efstathios T Pavlidis, Maria Lambropoulou, Nikolaos G Symeonidis, Constantinos Anagnostopoulos, Alexandra Tsaroucha, Athanasia Kotini, Christina Nikolaidou, Anastasia Kiziridou, Constantinos Simopoulos
Purpose/aim: To examine with immunohistochemical assay MTA1 protein expression levels in pancreatic cancer tissues defining its prognostic value. MATERIAL AND METHODS: The specimens derived from 51 patients who underwent surgery. The levels of MTA1 protein were compared with the age of the patients, their survival, and prognosis. Also, we studied clinical and histopathological factors such as the degree of tumor differentiation and its stage in correlation with MTA1 protein levels. In parallel, there was correlation between the expression of the ΜΤΑ1 protein and the aforementioned factors regarding survival rate...
February 10, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28621272/radiopacity-of-mineral-trioxide-aggregate-with-and-without-inclusion-of-silver-nanoparticles
#19
Mariana Ss Mendes, Leonardo D Resende, Cláudia A Pinto, Denise P Raldi, Flavia Gr Cardoso, Sandra M Habitante
AIM: The aim of this study was to investigate the inclusion of silver nanoparticles (Ag NPs) in the mineral trioxide aggregate (MTA) composition to know which changes will result in the radiopacity of the material. MATERIALS AND METHODS: The experiment was performed according to the American National Standard Institute/American Dental Association specification no. 57/2000 and ISO 6876/2001. Five plates with five holes measuring 1 mm in depth and 5 mm in internal diameter were filled according to the different experimental groups as follows: white mineral trioxide aggregate (WMTA) + NP50 - W MTA with liquid Ag NP 50 ppm, WMTA + NP30 - W MTA with liquid Ag NP 30 ppm, WMTA + NP22 - W MTA with liquid Ag NP 22 ppm, WMTA + NPP - white MTA with liquid Ag NP and powder 1%, WMTA (control)...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28617075/follow-up-of-young-adults-with-adhd-in-the-mta-design-and-methods-for-qualitative-interviews
#20
Thomas S Weisner, Desiree W Murray, Peter S Jensen, John T Mitchell, James M Swanson, Stephen P Hinshaw, Karen Wells, Lily Hechtman, Brooke S G Molina, L Eugene Arnold, Page Sorensen, Annamarie Stehli
OBJECTIVE: Qualitative interviews with 183 young adults (YA) in the follow-up of the Multimodal Treatment Study of Children With and Without ADHD (MTA) provide rich information on beliefs and expectations regarding ADHD, life's turning points, medication use, and substance use (SU). METHOD: Participants from four MTA sites were sampled to include those with persistent and atypically high SU, and a local normative comparison group (LNCG). Respondents were encouraged to "tell their story" about their lives, using a semistructured conversational interview format...
June 1, 2017: Journal of Attention Disorders
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