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https://www.readbyqxmd.com/read/28334956/prune-is-crucial-for-normal-brain-development-and-mutated-in-microcephaly-with-neurodevelopmental-impairment
#1
Massimo Zollo, Mustafa Ahmed, Veronica Ferrucci, Vincenzo Salpietro, Fatemeh Asadzadeh, Marianeve Carotenuto, Reza Maroofian, Ahmed Al-Amri, Royana Singh, Iolanda Scognamiglio, Majid Mojarrad, Luca Musella, Angela Duilio, Angela Di Somma, Ender Karaca, Anna Rajab, Aisha Al-Khayat, Tribhuvan Mohan Mohapatra, Atieh Eslahi, Farah Ashrafzadeh, Lettie E Rawlins, Rajniti Prasad, Rashmi Gupta, Preeti Kumari, Mona Srivastava, Flora Cozzolino, Sunil Kumar Rai, Maria Monti, Gaurav V Harlalka, Michael A Simpson, Philip Rich, Fatema Al-Salmi, Michael A Patton, Barry A Chioza, Stephanie Efthymiou, Francesca Granata, Gabriella Di Rosa, Sarah Wiethoff, Eugenia Borgione, Carmela Scuderi, Kshitij Mankad, Michael G Hanna, Piero Pucci, Henry Houlden, James R Lupski, Andrew H Crosby, Emma L Baple
PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily of molecules important for cell motility, and implicated in cancer progression. Here we investigated multiple families from Oman, India, Iran and Italy with individuals affected by a new autosomal recessive neurodevelopmental and degenerative disorder in which the cardinal features include primary microcephaly and profound global developmental delay. Our genetic studies identified biallelic mutations of PRUNE1 as responsible. Our functional assays of disease-associated variant alleles revealed impaired microtubule polymerization, as well as cell migration and proliferation properties, of mutant PRUNE...
February 28, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28330893/analysis-of-mic-and-disk-diffusion-testing-variables-for-gepotidacin-and-comparator-agents-against-select-bacterial-pathogens
#2
L K Koeth, J M DiFranco-Fisher, N E Scangarella-Oman, L A Miller
This study was conducted to determine the effect of testing parameters on the in vitro activity of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of conventional and biothreat pathogens. CLSI methods, and variations of these methods were used to test 10 Staphylococcus aureus, 10 Streptococcus pneumoniae, 10 Haemophilus influenzae, and 5 Escherichia coli by MIC and 30 S. aureus, 15 S. pneumoniae and 15 S. pyogenes by disk diffusion (DD) methods. Levofloxacin and linezolid were tested as comparator agents for MIC and DD methods, respectively...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28330584/central-line-associated-sepsis-in-children-receiving-parenteral-nutrition-in-oman
#3
Tawfiq T Al Lawati, Adawaiya Al Jamie, Nasra Al Mufarraji
Parenteral Nutrition (PN) is used when gut fails to provide complete nutrition. Central line Associate Blood Stream Infection (CLABSI) a major complication of this therapy. The objective of the study was to report the incidence of CLABSI and associated mortality in children receiving PN in the Royal Hospital and study the indication and duration of PN use. All children from the age of 0-48 months who received TPN outside NICU from the period between 1/1/2011 till 31/12/2014 were included. Data were retrieved from the hospital electronic data base...
March 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28330456/genome-wide-expression-profiling-in-leaves-and-roots-of-date-palm-phoenix-dactylifera-l-exposed-to-salinity
#4
Mahmoud W Yaish, Himanshu V Patankar, Dekoum V M Assaha, Yun Zheng, Rashid Al-Yahyai, Ramanjulu Sunkar
BACKGROUND: Date palm, as one of the most important fruit crops in North African and West Asian countries including Oman, is facing serious growth problems due to salinity, arising from persistent use of saline water for irrigation. Although date palm is a relatively salt-tolerant plant species, its adaptive mechanisms to salt stress are largely unknown. RESULTS: In order to get an insight into molecular mechanisms of salt tolerance, RNA was profiled in leaves and roots of date palm seedlings subjected to NaCl for 10 days...
March 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28298861/retinopathy-of-prematurity-revisiting-incidence-and-risk-factors-from-oman-compared-to-other-countries
#5
Zenaida Soriano Reyes, Sharef Waadallah Al-Mulaabed, Flordeliz Bataclan, Cheryl Montemayor, Anuradha Ganesh, Sanaa Al-Zuhaibi, Huda Al-Waili, Fatma Al-Wahibi
PURPOSE: The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries. PATIENTS AND METHODS: A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. The incidence of ROP was reported...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298855/day-care-ophthalmic-surgeries-at-a-secondary-care-hospital-in-oman-our-experience
#6
EDITORIAL
Jagdish Bhatia, Bindu Narayanadas, Albert Alfy Hafez Gad, Mathew Varghese, Makari Adel Mansi
No abstract text is available yet for this article.
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28296228/coronavirus-infections-in-horses-in-saudi-arabia-and-oman
#7
M G Hemida, D K W Chu, R A P M Perera, R L W Ko, R T Y So, B C Y Ng, S M S Chan, S Chu, A A Alnaeem, M A Alhammadi, R J Webby, L L M Poon, U B R Balasuriya, M Peiris
Equine coronaviruses (ECoV) are the only coronavirus known to infect horses. So far, data on ECoV infection in horses remain limited to the USA, France and Japan and its geographic distribution is not well understood. We carried out RT-PCR on 306 nasal and 315 rectal swabs and tested 243 sera for antibodies to detect coronavirus infections in apparently healthy horses in Saudi Arabia and Oman. We document evidence of infection with ECoV and HKU23 coronavirus by RT-PCR. There was no conclusive evidence of Middle East respiratory syndrome coronavirus infection in horses...
March 13, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28293401/alloimmunization-in-patients-with-sickle-cell-disease-and-thalassemia-experience-of-a-single-centre-in-oman
#8
Salam Alkindi, Saba AlMahrooqi, Sumaiya AlHinai, Ali AlMarhoobi, Saif Al-Hosni, Shahina Daar, Naglaa Fawaz, Anil Pathare
BACKGROUND: Blood transfusion is an integral part of the supportive care for patients with sickle cell disease (SCD) and thalassaemia. The hazard of red cell alloimmunization, however, is one of the main complications of this therapy. OBJECTIVES: The aim of this study was to evaluate the prevalence of red cell alloimmunization in Omani patients with sickle cell anaemia and thalassemia. METHODS: This study included 262 patients whose historical transfusion records were available...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28286360/biogeography-and-molecular-diversity-of-coral-symbionts-in-the-genus-symbiodinium-around-the-arabian-peninsula
#9
Maren Ziegler, Chatchanit Arif, John A Burt, Sergey Dobretsov, Cornelia Roder, Todd C LaJeunesse, Christian R Voolstra
AIM: Coral reefs rely on the symbiosis between scleractinian corals and intracellular, photosynthetic dinoflagellates of the genus Symbiodinium making the assessment of symbiont diversity critical to our understanding of ecological resilience of these ecosystems. This study characterizes Symbiodinium diversity around the Arabian Peninsula, which contains some of the most thermally diverse and understudied reefs on Earth. LOCATION: Shallow water coral reefs throughout the Red Sea (RS), Sea of Oman (SO), and Persian/Arabian Gulf (PAG)...
March 2017: Journal of Biogeography
https://www.readbyqxmd.com/read/28264393/two-new-species-of-i-mendozellus-i-linnavuori-hemiptera-cicadellidae-deltocephalinae-deltocephalini-with-redescription-of-i-mendozellus-i-i-asunctia-i-cheng
#10
Yani Duan, Christopher H Dietrich, Yalin Zhang
Mendozellus paralaredanus sp. n. from Uruguay and M. rakitovi sp. n. from Peru are described. M. asunctia Cheng is redescribed, the ovipositor is illustrated for the first time, and newly recorded from Argentina. M. serratus DeLong is transferred to Haldorus Oman based on the male genitalia structure, creating the new combination H. serratus (DeLong), comb. n. A checklist and key to species of Mendozellus are provided.
February 15, 2017: Zootaxa
https://www.readbyqxmd.com/read/28264272/-i-persianorchestia-i-a-new-talitrid-genus-crustacea-amphipoda-talitridae-from-gulf-of-oman-iran
#11
Farzaneh Momtazi, Jim Lowry, Maryam Hekmatara
A new genus and species, Persianorchestia nirvana gen. et sp. nov., is described from the south coast of Iran along the Gulf of Oman. The new genus is characterized by large eyes, gnathopod 1 posterior margin of carpus and propodus each with lobe covered in palmate setae, smooth posterior margin on dactylus of male gnathopod 2, a slender dactylus on pereopod 5, uropod 1 outer ramus without marginal robust setae and with apical spear-shaped setae on the rami of uropods 1 and 2. Persianorchestia is most similar to Pseudorchestoidea Bousfield, 1982...
March 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28260132/imported-talaromycosis-in-oman-in-advanced-hiv-a-diagnostic-challenge-outside-the-endemic-areas
#12
Jalila Mohsin, Sulin Al Khalili, A H G Gerrits van den Ende, Faryal Khamis, Eskild Petersen, G Sybren de Hoog, Jacques F Meis, Abdullah M S Al-Hatmi
A 37-year-old male living in Oman was seen by his physician with complaints of cough, body aches with bilateral lower limb weakness and on and off fever. He was diagnosed with HIV infection and culture from blood and bone marrow grew Talaromyces marneffei. He had travelled to Malaysia on several occasions. Treatment with liposomal amphotericin B resulted in complete cure. This case is reported for its rarity and unusual presentation to alert clinicians and microbiologists to consider T. marneffei as an etiology in high risk individuals...
March 4, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28259724/current-status-of-crimean-congo-hemorrhagic-fever-in-who-eastern-mediterranean-region-issues-challenges-and-future-directions
#13
REVIEW
Seif S Al-Abri, Idris Al Abaidani, Mehdi Fazlalipour, Ehsan Mostafavi, Hakan Leblebicioglu, Natalia Pshenichnaya, Ziad A Memishemish, Roger Hewson, Jorgen Eskild Petersen, Peter Mala, Tran Minh Nhu Nguyen, Mamunur Rahman Malik, Pierre Formenty, Rosanna Lucy Jeffries
Crimean-Congo hemorrhagic fever (CCHF) is the most wide-spread, tick-borne viral disease affecting humans. The disease is endemic in many regions such as Africa, Asia, Eastern and Southern Europe, and Central Asia. Recently, the incidence of CCHF has increased rapidly in the countries of the Eastern Mediterranean Region of the World Health Organization (WHO), with sporadic human cases and outbreaks of CCHF being reported from a number of countries in the region. Despite the rapidly growing incidence of the disease, there is currently no accurate data on the burden of the disease in the region due to different surveillance systems for CCHF in the countries...
March 1, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28259621/long-term-improvements-in-knowledge-and-psychosocial-factors-of-a-teen-pregnancy-prevention-intervention-implemented-in-group-homes
#14
Jennifer Green, Roy F Oman, Minggen Lu, Kristen D Clements-Nolle
PURPOSE: Youth in out-of-home care have higher rates of sexual risk behaviors and pregnancy than youth nationally. This study aimed to determine if Power Through Choices (PTC), a teen pregnancy prevention program developed for youth in out-of-home care, significantly improves knowledge and psychosocial outcomes regarding HIV and sexually transmitted infections (STIs), sexual activity and contraception methods, long term. METHODS: A cluster randomized controlled trial was conducted with 1,036 ethnically diverse youths (aged 13-18 years) recruited from 44 residential group homes in three states...
March 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28256205/assessment-of-226-ra-238-u-232-th-137-cs-and-40-k-activities-from-the-northern-coastline-of-oman-sea-water-and-sediments
#15
F Darabi-Golestan, A Hezarkhani, M R Zare
Water and sediment samples were collected from northern coast of Oman Sea covering from Goatr to Hormoz canyon seaport. Water and sediment quality assessment for naturally or anthropogenic radionuclides at Oman Sea as a main strategic golf for trade and transit, is an important issue. Correspondence analysis (CA) by R-mode analysis represents that sigma(T)-temperature-conductivity-O2 parameters are well-correlated with (226)Ra, (232)Th and (40)K. Accordingly Q-mode analysis revealed an indicator samples of ST13W for different radionuclides, ST03W for O2, and simultaneously ST34W-ST21W-ST08W-ST04W for sigma(T) parameters...
February 27, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28238347/liver-and-kidney-toxicity-induced-by-afzal-smokeless-tobacco-product-in-oman
#16
Nawal Al-Mukhaini, Taher Ba-Omar, Elsadig Eltayeb, Aisha Al-Shihi, Nafila Al-Riyami, Jamila Al-Belushi, Kawthar Al-Adawi
Afzal, the common smokeless tobacco product (STP) in Oman, is believed to contain toxins that may impair the function of some organs such as liver and kidney. An aqueous extract from Afzal was added to drinking water to be administrated orally to Wistar albino rats (n=72) young and adult from both genders weighing between 60-80g and 150-240g respectively for 8 weeks. Animals were divided into three groups: control (distilled water instead of Afzal extract), low-dose (3mgnicotine/kgbodyweight/day) and high-dose (6mgnicotine/kgbodyweight/day)...
February 6, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28236255/a-call-for-more-research-from-the-arabian-gulf
#17
Fatemah AlMarri, Salman Al Sabah, Eliana Al Haddad, Jonathan D Vaz
INTRODUCTION: Obesity has become an epidemic in the Arabian Gulf, with the prevalence of obesity according to the latest report from the World Health Organization (WHO) showing the gulf region to be countries with the highest incidence of obesity in the 30% plus group. This study aims to examine publications on bariatric surgery and compare them with the other countries with a high incidence of obesity in the world. METHODS: A literature review on bariatric surgery published from the earliest detected year of publication up until March 2016 using SCOPUS, PubMed, Ovid, and Google Scholar was conducted...
February 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28223966/geological-and-geochemical-controls-on-subsurface-microbial-life-in-the-samail-ophiolite-oman
#18
Kaitlin R Rempfert, Hannah M Miller, Nicolas Bompard, Daniel Nothaft, Juerg M Matter, Peter Kelemen, Noah Fierer, Alexis S Templeton
Microbial abundance and diversity in deep subsurface environments is dependent upon the availability of energy and carbon. However, supplies of oxidants and reductants capable of sustaining life within mafic and ultramafic continental aquifers undergoing low-temperature water-rock reaction are relatively unknown. We conducted an extensive analysis of the geochemistry and microbial communities recovered from fluids sampled from boreholes hosted in peridotite and gabbro in the Tayin block of the Samail Ophiolite in the Sultanate of Oman...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28223866/cross-national-analysis-of-estimated-narcotic-utilization-for-twelve-arabic-speaking-countries-in-the-middle-east
#19
Kyle John Wilby, Kerry Wilbur
BACKGROUND: Access to narcotics has been described as suboptimal in the Middle East. The objectives of this study were to characterize estimated narcotic use in twelve Arabic-speaking nations and compare across world regions. METHODS: This was a population-based cross-sectional analysis of estimated average consumption of narcotic drugs in defined daily doses per million inhabitants, as provided by the International Narcotics Control Board Technical Reports (2008-2012)...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28216955/patterns-of-prescription-drugs-use-among-pregnant-women-at-sultan-qaboos-university-hospital-and-sultan-qaboos-university-hospital-family-and-community-medicine-clinic-oman
#20
J Z Al-Hamimi, K A Al Balushi
OBJECTIVE: This study evaluates the patterns of prescription drugs use among women attending antenatal clinic at Sultan Qaboos University Hospital (SQUH) and SQUH Family and Community Medicine clinic (FAMCO), Oman. METHODS: The study was a descriptive retrospective cross-sectional study on pregnant women who attended the antenatal clinic at SQUH and FAMCO from February to April 2014 and received a prescription containing at least one drug. Patients' information was extracted from SQUH electronic records...
October 2016: Journal of Pharmacy & Bioallied Sciences
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