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https://www.readbyqxmd.com/read/29679801/metabolic-control-apoe-genotypes-and-dyslipidemia-in-children-adolescents-and-young-adults-with-type-1-diabetes
#1
Maddalena Macedoni, Tinka Hovnik, Emil Plesnik, Primoz Kotnik, Natasa Bratina, Tadej Battelino, Urh Groselj
BACKGROUND AND AIMS: Limited data is available on the factors influencing the lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. We aimed at assessing the influences of metabolic control and ApoE genotypes on lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. METHODS: Children, adolescents and young adults with type 1 diabetes from our nationwide cohort attending the annual check-up were prospectively included...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29679763/leaving-the-nest-improving-food-allergy-management-on-college-campuses
#2
Ashley A Dyer, Amy O'Keefe, Madeleine K Kanaley, Lauren Kao, Ruchi S Gupta
BACKGROUND: The transition from adolescence to young adulthood marks a developmental period where responsibility for management of chronic conditions such as food allergy shifts from the caregiver to the young adult. Fatal food-induced anaphylaxis is most common among adolescents and young adults. However, colleges are currently not well-positioned to provide integrated support for students with food allergies. OBJECTIVE: The study objective was to explore the systems, structures, and policies that currently support students with food allergies at college, assess unmet needs, and develop pilot interventions through the use of patient-centered design processes...
April 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29679735/age-dependent-effects-of-brain-stimulation-on-network-centrality
#3
Daria Antonenko, Till Nierhaus, Marcus Meinzer, Kristin Prehn, Axel Thielscher, Bernd Ittermann, Agnes Flöel
Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate age-associated differential neural tDCS effects. Three "online" tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults...
April 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29679609/cannabis-sativa-marijuana-alters-blood-chemistry-and-the-cytoarchitecture-of-some-organs-in-sprague-dawley-rat-models
#4
Nosarieme Omoregie Abey
There is evidence that Cannabis whose active ingredient is tetrahydrocannabinol (THC) is the most commonly abused neuroactive substance, among young adults. This work investigated the effects of Cannabis sativa on the cytoarchitecture of some key organs and the blood chemistry of rat models. Twenty-one (21) male Sprague Dawley rats were fed different percentage of cannabis chow (0%, 5% and 10%) for a period of seven (7) weeks. Rats were subjected to intermittent cognitive function test and sacrificed after the seventh week, collecting the blood, brain and other important tissues for analysis which include; brain total protein and nitric oxide concentration, blood chemistry and histopathology...
April 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679544/1-f-neural-noise-and-electrophysiological-indices-of-contextual-prediction-in-aging
#5
S Dave, T A Brothers, T Y Swaab
Prediction of upcoming words during reading has been suggested to enhance the efficiency of discourse processing. Emerging models have postulated that predictive mechanisms require synchronous firing of neural networks, but to date, this relationship has been investigated primarily through oscillatory activity in narrow frequency bands. A recently-developed measure proposed to reflect broadband neural activity - and thereby synchronous neuronal firing - is 1/f neural noise extracted from EEG spectral power...
April 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29679503/prosthetic-rehabilitation-of-patients-with-hypohidrotic-ectodermal-dysplasia-a-systematic-review
#6
REVIEW
Dagmar Schnabl, Ingrid Grunert, Matthias Schmuth, Ines Kapferer-Seebacher
BACKGROUND: Hypohidrotic ectodermal dysplasia (HED) comprises a large group of inherited disorders of ectodermal structures, characterized by hypo-/anhidrosis, hypotrichosis and hypo-/oligo-/anodontia. OBJECTIVE: We aimed to systematically assess the spectrum of prosthodontic approaches with regard to the patients' age and to provide clinical implications for practicing dentists. METHODS: An electronic and manual search was conducted in four databases (Medline, LIVIVO, Cochrane Library, Web of Science Core Collection)...
April 21, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29679496/detection-of-bone-marrow-derived-fibrocytes-in-human-dental-pulp-repair
#7
N Yoshiba, N Edanami, A Tohma, R Takeuchi, N Ohkura, A Hosoya, Y Noiri, H Nakamura, K Yoshiba
AIM: To explore the expression profile of CD45+/pro-collagen I+ fibrocytes in intact dental pulps as well as during wound healing in adult dental pulp tissue. METHODOLOGY: A total of 16 healthy permanent teeth were obtained from young patients (18 to 25 years) undergoing orthodontic treatment. Routine pulp capping with mineral trioxide aggregate (MTA) was performed under local anaesthesia to induce a mineralized barrier at the exposed surface. Teeth were extracted from patients after 7, 14, and 35 days...
April 21, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29679360/mental-health-of-the-male-adolescent-and-young-man-the-copenhagen-statement
#8
REVIEW
Timothy R Rice, Lesha D Shah, Pilar Trelles, Shih-Ku Lin, Dinne Skjærlund Christensen, Andreas Walther, Leo Sher
BACKGROUND: Male adolescents and young men benefit when their mental health care is specialized to match their unique gendered and developmental needs. Sensitivity to the social circumstances of this population is important; additionally, the emerging ability to tailor care through knowledge gleaned from the intersection of psychiatry, neurology, and endocrinology informs care. DATA SOURCES: This article summarized the views of six experts in the area of the adolescent and young adult male mental health...
April 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29679203/a-window-into-extreme-longevity-the-circulating-metabolomic-signature-of-the-naked-mole-rat-a-mammal-that-shows-negligible-senescence
#9
Kaitlyn N Lewis, Nimrod D Rubinstein, Rochelle Buffenstein
Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not conform to Gompertzian laws of age-related mortality; adults show no age-related change in mortality risk. Moreover, we observe negligible hallmarks of aging with well-maintained physiological and molecular functions, commonly altered with age in other species. We questioned whether naked mole-rats, living an order of magnitude longer than laboratory mice, exhibit different plasma metabolite profiles, which could then highlight novel mechanisms or targets involved in disease and longevity...
April 20, 2018: GeroScience
https://www.readbyqxmd.com/read/29679072/polyunsaturated-fatty-acids-metabolism-purine-metabolism-and-inosine-as-potential-independent-diagnostic-biomarkers-for-major-depressive-disorder-in-children-and-adolescents
#10
Xinyu Zhou, Lanxiang Liu, Xinghui Lan, David Cohen, Yuqing Zhang, Arun V Ravindran, Shuai Yuan, Peng Zheng, David Coghill, Lining Yang, Sarah E Hetrick, Xiaofeng Jiang, Jean-Jacques Benoliel, Andrea Cipriani, Peng Xie
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to explore the potential biomarkers of depression in children and adolescents with MDD. We identified several perturbed pathways, including fatty acid metabolism-particularly the polyunsaturated fatty acids metabolism, and purine metabolism-that were associated with MDD in these young patients...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29678801/stigma-and-its-association-with-glycemic-control-and-hypoglycemia-in-adolescents-and-young-adults-with-type-1-diabetes-cross-sectional-study
#11
Anne-Sophie Brazeau, Meranda Nakhla, Michael Wright, Mélanie Henderson, Constadina Panagiotopoulos, Daniele Pacaud, Patricia Kearns, Elham Rahme, Deborah Da Costa, Kaberi Dasgupta
BACKGROUND: Qualitative studies in type 1 diabetes indicate that visibility of diabetes supplies, self-care, and hypoglycemia symptoms are associated with stigma and suboptimal management. This may be particularly salient in youth who face concurrent challenges such as establishing autonomy and making vocational choices. OBJECTIVE: The aim of the study was to estimate stigma prevalence in youth (aged 14-24 years) with type 1 diabetes and its associations with glycemic control...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29678800/the-korean-ehealth-literacy-scale-k-eheals-reliability-and-validity-testing-in-younger-adults-recruited-online
#12
SeonYoon Chung, Bu Kyung Park, Eun-Shim Nahm
BACKGROUND: In this digital era, eHealth literacy is an essential skill set to leverage health information available online to promote health outcomes. South Korea has an advanced health information technology infrastructure, including widespread use of the internet and mobile phones. A few studies have explored eHealth literacy in South Korea using translated versions of the eHEALS; however, they were not fully validated. A unified reliable and valid assessment tool is critical to assess and enhance the eHealth literacy level across the population...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29678798/analysis-of-college-students-personal-health-information-activities-online-survey
#13
Sujin Kim, Donghee Sinn, Sue Yeon Syn
BACKGROUND: With abundant personal health information at hand, individuals are faced with a critical challenge in evaluating the informational value of health care records to keep useful information and discard that which is determined useless. Young, healthy college students who were previously dependents of adult parents or caregivers are less likely to be concerned with disease management. Personal health information management (PHIM) is a special case of personal information management (PIM) that is associated with multiple interactions among varying stakeholders and systems...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29678777/a-10-year-review-of-sudden-death-during-sporting-activities
#14
Mark Dennis, Alexander Elder, Christopher Semsarian, John Orchard, Isabel Brouwer, Rajesh Puranik
BACKGROUND: Sudden death during sport is a rare but devastating event. Previous research has mostly focused on sudden deaths in young competitive athletes. OBJECTIVE: To characterise the demographics and aetiology of sudden cardiac death (SCD) during sport in Australia. METHODS: All autopsies conducted at our forensic medicine facility between the years 2006-2015 (inclusive) were reviewed. Sporting related deaths amongst those 7-65 years of age were identified...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29678393/positive-correlations-between-free-vitamin-d-and-bone-variables-in-a-group-of-young-lebanese-women
#15
Abir Alwan, Maroun Rizkallah, Ghassan Maalouf, Joseph Matta, Fabienne Frenn, Angélique Barakat, Falah Bachour, Amer Sebaaly, Abdel-Jalil Berro, Nathalie Al Rassy, Mirza Howayek, Hassane Zouhal, Rawad El Hage
Optimizing bone mass in adulthood is of great importance to prevent the occurrence of osteoporosis in later age. Vitamin D is an essential component of bone health. Low-serum vitamin D is associated with low bone mineral density (BMD), which is an important predictor of fracture risk. However, most cells, apart from renal tubular cells, are exposed to free rather than to total 25-hydroxyvitamin D. Whether free vitamin D would be a better marker than total vitamin D is still under debate. The aim of the present study was to explore the relationships between serum total vitamin D, vitamin D-binding protein (BP), free vitamin D, and bone parameters in a group of young Lebanese women...
March 26, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29678123/binge-drinking-among-young-adults-in-israel-application-of-the-theory-of-planned-behavior
#16
Maayan Lawental, Anna Kipnis, Khary Rigg
Binge drinking is common among young people, and is an area of concern in many countries worldwide. Israel has seen a steady increase in binge drinking behaviors in recent years among youth and young adults. Using the Theory of Planned Behavior (TPB) as a guiding theoretical framework, this study examines whether attitudes, subjective norms, perceived behavioral control and intention to engage in binge drinking are correlated with individual participation in binge drinking among young adults aged 18-35 in Israel...
April 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29677688/relating-shape-weight-based-self-esteem-depression-and-anxiety-with-weight-and-perceived-physical-health-among-young-adults
#17
Rebecca C Kamody, Idia B Thurston, Kristina M Decker, Caroline C Kaufman, Kendrin R Sonneville, Tracy K Richmond
Simultaneous contributions of self-esteem, depression, and anxiety to weight and perceived physical health in young adults is understudied. A diverse sample of 424 young adults completed measures of shape/weight based self-esteem, depression, anxiety, and perceived physical health. Height and weight were measured to calculate body mass index (BMI). Latent profile analysis was conducted to derive patterns of depression, anxiety, and shape/weight based self-esteem. Then, we examined the association of the profiles with weight status and perceived physical health...
April 17, 2018: Body Image
https://www.readbyqxmd.com/read/29677465/the-effect-of-sex-menstrual-cycle-phase-and-monophasic-oral-contraceptive-pill-use-on-local-and-central-arterial-stiffness-in-young-adults
#18
Stacey E Priest, Ninette Shenouda, Maureen J MacDonald
Arterial stiffness is associated with increased cardiovascular disease risk. Previous sex-based investigations of local and central stiffness report inconsistent findings and have not controlled for menstrual cycle phase in women. There is also evidence that sex hormones influence the vasculature, but their impact on arterial stiffness across a natural menstrual (NAT) or oral contraceptive pill (OCP) cycle has been understudied. This study sought to 1) examine potential sex differences in local and central stiffness, 2) compare stiffness profiles between NAT and OCP cycles, and 3) investigate the relationship between duration of OCP use and arterial stiffness...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29676999/sex-differences-in-transcriptomic-profiles-in-aged-kidney-cells-of-renin-lineage
#19
Yuliang Wang, Diana G Eng, Jeffrey W Pippin, Sina A Gharib, Aaron McClelland, Kenneth W Gross, Stuart J Shankland
Renin expressing cells in the kidney's juxta-glomeruluar compartment likely also serve as progenitors for adult glomerular cells in disease. Although these cells of renin lineage (CoRL) decrease in number with advancing kidney age, accompanied by less responsiveness to typical stimuli such as ACE-inhibition, mechanisms and the impact of sex as a biological variable with age are not known. Accordingly, labeled CoRL were sorted from individual young (2m) and aged (27m) male and female Ren1cCre|ZsGreen reporter mice, and their transcriptomic profiles analyzed by RNA seq...
April 18, 2018: Aging
https://www.readbyqxmd.com/read/29676652/-here-s-to-a-night-of-drunken-mistakes-exploring-experiences-regrets-and-optimism-in-young-adult-drinkers
#20
Emma L Davies, Mary Sissons Joshi
BACKGROUND: Studies exploring "anticipated regret" concerning alcohol rarely consider the broader consequences of excessive drinking that might be regretted. Even if specific regrettable experiences are identified, interventions targeting them may not succeed because individuals are often optimistic about their risk susceptibility. OBJECTIVES: This study examined the consequences young adult drinkers reported, and the extent to which these were regretted...
April 20, 2018: Substance Use & Misuse
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