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https://www.readbyqxmd.com/read/28527265/-profile-of-lithium-carbonate-use-in-patients-with-bipolar-disorder-in-colombia
#1
Manuel Enrique Machado-Duque, Catalina Alzate-Carvajal, Kevin Zapata-Castañeda, Jorge Enrique Machado-Alba
INTRODUCTION: Lithium is the drug of choice for the treatment of bipolar affective disorder. OBJECTIVE: To define lithium therapeutic profile and adverse reactions to its use in patients with bipolar affective disorder in Colombia. MATERIALS AND METHODS: We conducted an observational retrospective cohort study between January 1 and December 31, 2013, which included patients with a diagnosis of bipolar disorder treated with lithium carbonate in 25 Colombian cities; we evaluated socio-demographic variables, lithium dose, co-medication, drug interactions and adverse reactions...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28525775/the-association-between-systemic-lupus-erythematosus-and-bipolar-disorder%C3%A2-%C3%A2-a-big-data-analysis
#2
S Tiosano, Z Nir, O Gendelman, D Comaneshter, H Amital, A D Cohen, D Amital
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has a wide variety of physical manifestations, including neuropsychiatric features. Bipolar disorder (BD) is a chronic, episodic illness, that may present as depression or as mania. The objective of this study was to investigate the association between SLE and BD using big data analysis methods. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of BD in a cross-sectional study...
April 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28511406/effect-of-sodium-valproate-and-docosahexaenoic-acid-on-pain-in-rats
#3
REVIEW
Sushil Kiran Kunder, Laxminarayana Kurady Bairy, Avinash Arivazhahan
INTRODUCTION: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient's consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508277/surgical-management-of-obesity-among-people-with-schizophrenia-and-bipolar-disorder-a-systematic-review-of-outcomes-and-recommendations-for-future-research
#4
Youssef Kouidrat, Ali Amad, Brendon Stubbs, Suzan Moore, Fiona Gaughran
BACKGROUND: People with schizophrenia or bipolar disorder (BD) exhibit very high levels of obesity. Little is known about the potential benefits/risks of obesity surgery. We conducted a narrative review to summarize the available knowledge on bariatric surgery in people with schizophrenia or BD. METHODS: A systematic search was conducted of major electronic databases from inception to October 2016 for studies investigating bariatric surgery among people with schizophrenia or BD...
May 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#5
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28503113/who-s-the-leader-mania-or-depression-predominant-polarity-and-alcohol-polysubstance-use-in-bipolar-disorders
#6
Delfina Janiri, Marco Di Nicola, Giovanni Martinotti, Luigi Janiri
BACKGROUND: Predominant polarity characterises patients who mainly manifest recurrences of depression or mania/hypomania. Alcohol use disorder (AUD) and polysubstance use (PSU), which often complicate bipolar disorder (BD) and affect its clinical course, can influence predominant polarity. Nevertheless, previous studies have not clarified if BD patients differ in predominant polarity from BD patients with substance use disorder (SUD) comorbidity. OBJECTIVE: The aim of this study was to compare predominant polarity between BD without SUD, BD with AUD and BD with PSU...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503112/athanasios-koukopoulos-psychiatry-the-primacy-of-mania-and-the-limits-of-antidepressants
#7
REVIEW
S Nassir Ghaemi, Paul A Vohringer
BACKGROUND: Athanasios Koukopoulos provided a radical model for understanding depressive and manic conditions. OBJECTIVE: To review, explain, and analyze Koukopoulos' concept of the primacy of mania, with special attention to the role of antidepressants. METHOD: A conceptual review of Koukopoulos' writings and lectures on this topic is given. RESULTS: Koukopoulos held that depressive states are caused by manic states; the former do not occur without the latter...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28503109/parental-reports-of-prodromal-psychopathology-in-pediatric-bipolar-disorder
#8
Mariely Hernandez, Ciro Marangoni, Marie C Grant, Jezelle Estrada, Gianni L Faedda
OBJECTIVES: Early psychopathology in children diagnosed with Bipolar Disorder (BD) remains poorly characterized. Parental retrospective reports provide helpful details on the earliest manifestations and their evolution over time. These symptoms occur early in the course of BD, often before a formal diagnosis is made and/or treatment is implemented, and are of great importance to early recognition and prevention. METHODS: Parents of pre-pubertal children and adolescents with DSM-IV diagnoses of BD attending an outpatient mood disorders clinic provided retrospective ratings of 37 symptoms of child psychopathology...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28501506/defective-neuronal-migration-and-inhibition-of-bipolar-to-multipolar-transition-of-migrating-neural-cells-by-mesoderm-specific-transcript-mest-in-the-developing-mouse-neocortex
#9
Liting Ji, Kausik Bishayee, Ali Sadra, Seunghyuk Choi, Wooyul Choi, Sungho Moon, Eek-Hoon Jho, Sung-Oh Huh
Brain developmental disorders such as lissencephaly can result from faulty neuronal migration and differentiation during the formation of the mammalian neocortex. The cerebral cortex is a modular structure, where developmentally, newborn neurons are generated as a neuro-epithelial sheet and subsequently differentiate, migrate and organize into their final positions in the cerebral cortical plate via a process involving both tangential and radial migration. The specific role of Mest, an imprinted gene, in neuronal migration has not been previously studied...
May 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28500983/night-sleep-influences-white-matter-microstructure-in-bipolar-depression
#10
Francesco Benedetti, Elisa M T Melloni, Sara Dallaspezia, Irene Bollettini, Clara Locatelli, Sara Poletti, Cristina Colombo
BACKGROUND: Alteration of circadian rhythms and sleep disruption are prominent trait-like features of bipolar disorder (BD). Diffusion tensor imaging (DTI) measures suggest a widespread alteration of white matter (WM) microstructure in patients with BD. Sleep promotes myelination and oligodendrocyte precursor cells proliferation. We hypothesized a possible association between DTI measures of WM microstructure and sleep quantity measures in BD. METHODS: We studied 69 inpatients affected by a depressive episode in course of type I BD...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28500982/abnormal-sleep-duration-associated-with-hastened-depressive-recurrence-in-bipolar-disorder
#11
Anda Gershon, Dennis Do, Satyanand Satyanarayana, Saloni Shah, Laura D Yuen, Farnaz Hooshmand, Shefali Miller, Po W Wang, Terence A Ketter
BACKGROUND: Abnormal sleep duration (ASD, <6 or ≥9h) is common in bipolar disorder (BD), and often persists beyond acute mood episodes. Few longitudinal studies have examined the ASD's impact upon BD illness course. The current study examined the longitudinal impact of ASD upon bipolar depressive recurrence/recovery. METHODS: Outpatients referred to the Stanford BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation at baseline, and with the Clinical Monitoring Form at monthly follow-ups for up to two years of naturalistic treatment...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28500175/spatial-resolution-requirements-for-accurate-identification-of-drivers-of-atrial-fibrillation
#12
Caroline H Roney, Chris D Cantwell, Jason D Bayer, Norman A Qureshi, Phang Boon Lim, Jennifer H Tweedy, Prapa Kanagaratnam, Nicholas S Peters, Edward J Vigmond, Fu Siong Ng
BACKGROUND: Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping may lead to misinterpretation of the underlying mechanism in persistent AF. METHODS AND RESULTS: Simulations of rotors and focal sources were performed to estimate the minimum number of recording points required to correctly identify the underlying AF mechanism...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28497736/-implication-of-human-endogenous-retroviruses-in-schizophrenia-and-bipolar-disorder
#13
Pierre Ellul, Laurent Groc, Marion Leboyer
Schizophrenia and bipolar disorder are neuropsychiatric disorders of unknown origin. It seems that these two disorders share some common etiopathogenic mechanisms including genetic, environmental and inflammatory ones. Reactivation of the human endogenous retrovirus type W (HERV-W) can be a shared element in the pathophysiology of schizophrenia and bipolar disorder, linked to immuno-genetic and environment risk factors. We will present studies that have highlighted the presence of HERV-W in schizophrenic and bipolar disorder patients...
April 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28497721/scale-effects-in-moral-relevance-assessment
#14
Jonas Nagel, Andrej Rybak
Research on moral judgment often employs bipolar rating scales to assess whether the difference between two contrasted options is judged to be morally relevant. We give an account of how different numbers of response options provided on such scales (odd vs. even) change the meaning of the test question by communicating different implicit presuppositions. We demonstrate experimentally that these changes can qualitatively affect the moral relevance judgments that subjects express in response to a given judgment problem...
March 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28494347/structural-brain-abnormalities-in-patients-with-type-i-bipolar-disorder-and-suicidal-behavior
#15
Dante G G Duarte, Maila de Castro L Neves, Maicon R Albuquerque, Gustavo Turecki, Yang Ding, Fabio Luis de Souza-Duran, Geraldo Busatto, Humberto Correa
Some studies have identified brain morphological changes in the frontolimbic network (FLN) in bipolar subjects who attempt suicide (SA). The present study investigated neuroanatomical abnormalities in the FLN to find a possible neural signature for suicidal behavior in patients with bipolar disorder type I (BD-I). We used voxel-based morphometry to compare euthymic patients with BD-I who had attempted suicide (n=20), who had not attempted suicide (n=19) and healthy controls (HCs) (n=20). We also assessed the highest medical lethality of their previous SA...
May 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28490234/are-self-rated-and-behavioural-measures-of-impulsivity-in-bipolar-disorder-mainly-related-to-comorbid-substance-use-problems
#16
Isabelle E Bauer, Thomas D Meyer, Marsal Sanches, Danielle Spiker, Giovana Zunta-Soares, Jair C Soares
INTRODUCTION: Impulsivity is a multidimensional feature observed in bipolar disorder (BD) and substance use disorder (SUD). We previously found a relationship between SUD and risk taking in BD. It is still unclear whether self-rated and behavioral impulsivity measures differ between BD with and without comorbid SUD, or are specific to BD. METHODS: 93 adults with BD with comorbid SUD, 91 BD without SUD, and 93 healthy controls (HC) were administered the Barratt Impulsivity Scale (BIS), the Behavioral Inhibition/Behavioral Activation System Scale (BIS/BAS), and the Cambridge Neuropsychological Test Automated Battery...
May 11, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28488895/sleep-quality-chronotype-temperament-and-bipolar-features-as-predictors-of-depressive-symptoms-among-medical-students
#17
Łukasz Mokros, Andrzej Witusik, Julia Michalska, Wojciech Łężak, Michał Panek, Katarzyna Nowakowska-Domagała, Adam Antczak, Tadeusz Pietras
The assessment of risk factors is a crucial step in the prevention and treatment of affective disorders and should encompass personal dispositions. The aim of this study was to assess the value of chronotype and temperament as independent predictors of depressive symptoms among medical students. The study surveyed 140 students of the Faculty of Medicine with a battery of questionnaires: the Beck Depression Index (BDI), Hypomania Checklist 32 (HCL-32), Pittsburgh Sleep Quality Index (PSQI), Chronotype Questionnaire and Eysenck Personality Questionnaire Revised...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28485725/sensory-integration-deficits-support-a-dimensional-view-of-psychosis-and-are-not-limited-to-schizophrenia
#18
O Carter, D Bennett, T Nash, S Arnold, L Brown, R Y Cai, Z Allan, A Dluzniak, K McAnally, D Burr, S Sundram
Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28484349/one-year-follow-up-of-patients-with-a-diagnosis-of-first-episode-psychosis
#19
Atena Enderami, Fatemeh Sheikh Monesi, Mehran Zarghami
INTRODUCTION: Early diagnosis of symptoms related to psychotic disorders causes hyper responsiveness, recurrence reduction and quality of life improvement. The aim of this study was one-year follow-up of the clinical course and outcomes of hospitalized patients with first episode psychotic disorders and detection of factors affecting consequences. METHODS: This longitudinal descriptive study was conducted during 2012 to 2013 on hospitalized patients at Zare Hospital in Sari, Iran, with any psychotic symptoms and with diagnosis of first episode psychosis...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28483662/the-management-of-polyps-in-female-reproductive-organs
#20
REVIEW
Vasilios Tanos, Kelsey Elizabeth Berry, Jaana Seikkula, Elissa Abi Raad, Andreas Stavroulis, Zaki Sleiman, Rudi Campo, Stephan Gordts
Polyps of the lower reproductive tract are found in 7.8-50% of women. It has been hypothesized that cytogenetic modifications on chromosomes 6, 7 and 12 as well as epigenetic factors involving enzyme and metabolic activities may cause polyps to develop. Cervical polyps found in 2-5% of cases are of low clinical significance and can cause, although rarely, post coital bleedings. Cervical polyps grow during pregnancy and mucorrhoea. Trans vaginal ultrasound (TVU) provides an excellent diagnostic technique to diagnose the size and the anatomic location of endometrial polyps (EPs)...
May 5, 2017: International Journal of Surgery
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