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https://www.readbyqxmd.com/read/28520464/suvorexant-for-the-treatment-of-insomnia-in-adolescents
#1
Kentaro Kawabe, Fumie Horiuchi, Marina Ochi, Kayoko Nishimoto, Shu-Ichi Ueno, Yasunori Oka
OBJECTIVES: Suvorexant is the first dual orexin receptor antagonist for treating insomnia. This study aimed to evaluate the tolerability, efficacy, and safety of suvorexant on insomnia in adolescents. METHODS: Thirty patients (8 male and 22 female; mean standard deviation age: 15.7 ± 2.4 years; range: 10-20) with insomnia were administered suvorexant. Clinical background, persistence rate, the Clinical Global Impression (CGI), and the Athens Insomnia Scale (AIS) were compared between patients who continued and discontinued suvorexant treatment...
May 18, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28515493/sleep-dream-a-little-dream
#2
Sian Lewis
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28513079/rem-sleep-behavior-disorder-in-parkinson-s-disease-and-other-synucleinopathies
#3
REVIEW
Erik K St Louis, Angelica R Boeve, Bradley F Boeve
Rapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography. Rapid eye movement sleep behavior disorder may be idiopathic or symptomatic and in both settings is highly associated with synucleinopathy neurodegeneration, especially Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure...
May 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28513054/is-there-a-common-motor-dysregulation-in-sleepwalking-and-rem-sleep-behaviour-disorder
#4
Mehdi Haridi, Sebastian Weyn Banningh, Marion Clé, Smaranda Leu-Semenescu, Marie Vidailhet, Isabelle Arnulf
This study sought to determine if there is any overlap between the two major non-rapid eye movement and rapid eye movement parasomnias, i.e. sleepwalking/sleep terrors and rapid eye movement sleep behaviour disorder. We assessed adult patients with sleepwalking/sleep terrors using rapid eye movement sleep behaviour disorder screening questionnaires and determined if they had enhanced muscle tone during rapid eye movement sleep. Conversely, we assessed rapid eye movement sleep behaviour disorder patients using the Paris Arousal Disorders Severity Scale and determined if they had more N3 awakenings...
May 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28482107/phasic-rem-transiently-approaches-wakefulness-in-the-human-cortex-a-single-pulse-electrical-stimulation-study
#5
Kiyohide Usami, Riki Matsumoto, Katsuya Kobayashi, Takefumi Hitomi, Masao Matsuhashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Study Objectives: To investigate the changes in cortical neural responses induced by external inputs during phasic rapid eye movement (REM) sleep. Methods: Single-pulse electrical stimulation (SPES) was directly applied to the human cortex during REM sleep through subdural electrodes, in seven patients who underwent invasive presurgical evaluation for intractable partial epilepsy. SPES was applied to parts of the cortex through the subdural electrodes, and induced cortical responses were recorded from adjacent and remote cortical areas...
May 8, 2017: Sleep
https://www.readbyqxmd.com/read/28476256/-the-post-traumatic-nightmare-or-the-ghost-of-past-trauma
#6
REVIEW
Pierrick Disdier
The post-traumatic nightmare is the reliving of traumatic scenes during sleep and is linked to post-traumatic stress disorder. Unlike other forms of dreams, it can happen at any stage of sleep, invasively, and makes the person relive their traumatic scenario, which can plunge them into a state of terror and shock. Post-traumatic nightmares thereby maintain and reactivate the traumatic memory. However, narration techniques can lead to a marked improvement and even the disappearance of these nightmares.
May 2017: Soins. Psychiatrie
https://www.readbyqxmd.com/read/28472777/anesthetic-dreaming-anesthesia-awareness-and-patient-satisfaction-after-deep-sedation-with-propofol-target-controlled-infusion-a-prospective-cohort-study-of-patients-undergoing-day-case-breast-surgery
#7
Marco Cascella, Roberta Fusco, Domenico Caliendo, Vincenza Granata, Domenico Carbone, Maria Rosaria Muzio, Giuseppe Laurelli, Stefano Greggi, Francesca Falcone, Cira Antonietta Forte, Arturo Cuomo
BACKGROUND: Anesthetic dreaming and anesthesia awareness are well distinct phenomena. Although the incidence of intraoperative awareness is more common among patients who reported a dream after surgery, the exact correlation between the two phenomena remains an unsolved rebus. The main purpose of this study was to investigate anesthetic dreaming, anesthesia awareness and psychological consequences eventually occurred under deep sedation. Intraoperative dreaming experiences were correlated with dream features in natural sleep...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28456054/nightmares-and-nonsuicidal-self-injury-the-mediating-role-of-emotional-dysregulation
#8
Chelsea R Ennis, Nicole A Short, Allison J Moltisanti, Caitlin E Smith, Thomas E Joiner, Jeanette Taylor
INTRODUCTION: Nonsuicidal self-injury (NSSI) is a transdiagnostic behavior associated with significant psychopathology. Research has shown a positive association between sleep disturbances, (e.g., nightmares and insomnia), and suicidal behavior, however, the relation between NSSI and sleep disturbances has yet to be examined. Sleep disturbances have been found to have a causal role in problems with emotional dysfunction. Specifically, sleep disturbances inhibit the emotion processing function of sleep...
April 18, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28451897/sleeping-paranoia-away-an-actigraphy-and-experience-sampling-study-with-adolescents
#9
Timo Hennig, Tania M Lincoln
Paranoid symptoms co-occur with distress and poor functioning and constitute a risk for psychosis and other mental disorders. Poor sleep is known to be associated with paranoid symptoms, but the direction of the effect and the mediating factors have not been studied thoroughly. In an experience-sampling study, 61 adolescents wore an actigraph over eight nights and also rated their sleep, symptoms of paranoia, and potentially mediating factors. Shorter sleep time and more dreaming predicted paranoid symptoms in multilevel regression models...
April 27, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28434101/predicting-dream-recall-eeg-activation-during-nrem-sleep-or-shared-mechanisms-with-wakefulness
#10
Serena Scarpelli, Aurora D'Atri, Anastasia Mangiaruga, Cristina Marzano, Maurizio Gorgoni, Cinzia Schiappa, Michele Ferrara, Luigi De Gennaro
The common knowledge of a uniqueness of REM sleep as a privileged scenario of dreaming still persists, although consolidated empirical evidence shows that the assumption that dreaming is just an epiphenomenon of REM sleep is no longer tenable. However, the brain mechanisms underlying dream generation and its encoding in memory during NREM sleep are still mostly unknown. In fact, only few studies have investigated on the mechanisms of dream phenomenology related to NREM sleep. For this reason, our study is specifically aimed to elucidate the electrophysiological (EEG) correlates of dream recall (DR) upon NREM sleep awakenings...
April 22, 2017: Brain Topography
https://www.readbyqxmd.com/read/28398690/use-of-nicotine-replacement-therapy-in-young-people-entering-custody-in-new-south-wales-australia
#11
Leigh Haysom, Dianne Lawrence, Donna Mellish, Peter Burns, Pariza Khale, Ariana Arulampalam, Catherine Stapylton
AIM: To describe the prevalence of nicotine dependence and acceptance of nicotine replacement therapy (NRT) in young people entering custody, where smoking is not allowed. METHODS: Cross-sectional study in 2013. SETTING: All New South Wales Juvenile Justice Centres. PARTICIPANTS: Incarcerated youth, aged 12-21 years. MAIN EXPOSURES: gender, age, ethnicity, cannabis use. MAIN OUTCOMES: rates of smoking, cannabis use, nicotine dependence, NRT acceptance...
April 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28394322/the-neural-correlates-of-dreaming
#12
Francesca Siclari, Benjamin Baird, Lampros Perogamvros, Giulio Bernardi, Joshua J LaRocque, Brady Riedner, Melanie Boly, Bradley R Postle, Giulio Tononi
Consciousness never fades during waking. However, when awakened from sleep, we sometimes recall dreams and sometimes recall no experiences. Traditionally, dreaming has been identified with rapid eye-movement (REM) sleep, characterized by wake-like, globally 'activated', high-frequency electroencephalographic activity. However, dreaming also occurs in non-REM (NREM) sleep, characterized by prominent low-frequency activity. This challenges our understanding of the neural correlates of conscious experiences in sleep...
April 10, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28390699/deciphering-neural-codes-of-memory-during-sleep
#13
REVIEW
Zhe Chen, Matthew A Wilson
Memories of experiences are stored in the cerebral cortex. Sleep is critical for the consolidation of hippocampal memory of wake experiences into the neocortex. Understanding representations of neural codes of hippocampal-neocortical networks during sleep would reveal important circuit mechanisms in memory consolidation and provide novel insights into memory and dreams. Although sleep-associated ensemble spike activity has been investigated, identifying the content of memory in sleep remains challenging. Here we revisit important experimental findings on sleep-associated memory (i...
May 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28390613/self-reported-postoperative-recovery-in-children-after-tonsillectomy-compared-to-tonsillotomy
#14
Mats Eriksson, Ulrica Nilsson, Ann-Cathrine Bramhagen, Ewa Idvall, Elisabeth Ericsson
OBJECTIVES: Tonsil surgery is associated with significant morbidity during recovery. Patient-reported outcome measures (PROM) are the golden standard for the planning and follow-up of delivered care, which should also be an axiom for children. The current aims were to describe self-reported postoperative recovery in children after tonsil surgery, and to compare tonsillotomy and tonsillectomy in this respect. METHODS: In total, 238 children (4-12 years old) with a history of obstructive problems and/or recurrent tonsillitis, and undergoing tonsil surgery were included...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28377708/increased-evoked-potentials-to-arousing-auditory-stimuli-during-sleep-implication-for-the-understanding-of-dream-recall
#15
Raphael Vallat, Tarek Lajnef, Jean-Baptiste Eichenlaub, Christian Berthomier, Karim Jerbi, Dominique Morlet, Perrine M Ruby
High dream recallers (HR) show a larger brain reactivity to auditory stimuli during wakefulness and sleep as compared to low dream recallers (LR) and also more intra-sleep wakefulness (ISW), but no other modification of the sleep macrostructure. To further understand the possible causal link between brain responses, ISW and dream recall, we investigated the sleep microstructure of HR and LR, and tested whether the amplitude of auditory evoked potentials (AEPs) was predictive of arousing reactions during sleep...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28365447/suvorexant-for-the-treatment-of-primary-insomnia-a-systematic-review-and-meta-analysis
#16
REVIEW
Akira Kuriyama, Hiromitsu Tabata
Suvorexant is a dual orexin receptor agonist and is currently approved for the treatment of insomnia in the United States and Japan. We conducted a systematic review and meta-analysis to assess the efficacy and safety of suvorexant for the treatment of primary insomnia. We searched PubMed, EMBASE, and the Cochrane central register of controlled trials, contacted a relevant pharmaceutical company, and accessed websites of the U.S. Food and Drug Administration (FDA) and Pharmaceuticals and Medical Devices Agency (PMDA) for published and unpublished data...
October 28, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28364416/periodic-limb-movements-during-sleep-mimicking-rem-sleep-behavior-disorder-a-new-form-of-periodic-limb-movement-disorder
#17
Carles Gaig, Alex Iranzo, Montserrat Pujol, Hernando Perez, Joan Santamaria
Study Objectives: To describe a group of patients referred because of abnormal sleep behaviors that were suggestive of rapid eye movement (REM) sleep behavior disorder (RBD) in whom video-polysomnography ruled out RBD and showed the reported behaviors associated with vigorous periodic limb movements during sleep (PLMS). Aims and Methods: Clinical history and video-polysomnography review of patients identified during routine visits in a sleep center. Results: Patients were 15 men and 2 women with a median age of 66 (range: 48-77) years...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28357055/recent-advances-in-treating-parkinson-s-disease
#18
REVIEW
Wolfgang H Oertel
This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson's disease (PD) symptoms, (2) the still-few attempts to systematically search for symptomatic therapy of non-motor symptoms in PD, and (3) the advances in the development and clinical testing of compounds which promise to offer disease modification in already-manifest PD. However, prevention (that is, slowing or stopping PD in a prodromal stage) is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder (RBD) -a methodological challenge to be met in the future...
2017: F1000Research
https://www.readbyqxmd.com/read/28332861/treatment-of-nightmares-in-psychiatric-inpatients-with-imagery-rehearsal-therapy-an-open-trial-and-case-series
#19
Thomas E Ellis, Katrina A Rufino, Michael R Nadorff
OBJECTIVES: This study sought to assess the utility of Imagery Rehearsal Therapy (IRT) for nightmares in an inpatient psychiatric setting. Although IRT enjoys a substantial evidence base for efficacy in various populations, data with psychiatric inpatients are lacking. PARTICIPANTS: Participants were 20 adult psychiatric inpatients (11 male, 9 female; mean age=43.4), in an extended stay psychiatric inpatient facility. All participants were diagnosed with multiple, treatment resistant, comorbid conditions, including mood disorders, anxiety disorders, personality disorders, and substance-related disorders...
March 23, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28327005/to-sleep-perchance-to-dream
#20
Jane Bates
'Ne'er the good counsel of thy nurse despise; forsooth! Instil these drops into thine eyes. Not thrice but four times, as the hours do run, from the day's break to the setting of the sun.'
March 22, 2017: Nursing Standard
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