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https://www.readbyqxmd.com/read/28205180/methods-for-monitoring-abca1-dependent-sterol-release
#1
Yoshio Yamauchi, Shinji Yokoyama, Ta-Yuan Chang
Releasing sterols to the extracellular milieu is an important part of sterol homeostasis in cells and in the body. ATP-binding cassette transporter A1 (ABCA1) plays an essential role in cellular phospholipid and sterol release to lipid-free or lipid-poor apolipoprotein A-I (apoA-I), the major apolipoprotein in high-density lipoprotein (HDL), and constitutes the first step in the formation of nascent HDL. Loss-of-function mutations in the ABCA1 gene lead to a rare disease known as Tangier disease that causes severe deficiency in plasma HDL level...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28178320/variations-in-the-structural-and-functional-diversity-of-zooplankton-over-vertical-and-horizontal-environmental-gradients-en-route-to-the-arctic-ocean-through-the-fram-strait
#2
Marta Gluchowska, Emilia Trudnowska, Ilona Goszczko, Anna Maria Kubiszyn, Katarzyna Blachowiak-Samolyk, Waldemar Walczowski, Slawomir Kwasniewski
A multi-scale approach was used to evaluate which spatial gradient of environmental variability is the most important in structuring zooplankton diversity in the West Spitsbergen Current (WSC). The WSC is the main conveyor of warm and biologically rich Atlantic water to the Arctic Ocean through the Fram Strait. The data set included 85 stratified vertical zooplankton samples (obtained from depths up to 1000 metres) covering two latitudinal sections (76°30'N and 79°N) located across the multi-path WSC system...
2017: PloS One
https://www.readbyqxmd.com/read/28177515/methadone-for-cancer-pain
#3
REVIEW
Alexander B Nicholson, Graeme R Watson, Sheena Derry, Philip J Wiffen
BACKGROUND: This is an updated review originally published in 2004 and first updated in 2007. This version includes substantial changes to bring it in line with current methodological requirements. Methadone is a synthetic opioid that presents some challenges in dose titration and is recognised to cause potentially fatal arrhythmias in some patients. It does have a place in therapy for people who cannot tolerate other opioids but should be initiated only by experienced practitioners. This review is one of a suite of reviews on opioids for cancer pain...
February 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28166926/-neuroprotection-for-preterm-infants-with-antenatal-magnesium-sulphate
#4
S Marret, P-Y Ancel
OBJECTIVE: To evaluate in preterm born children the neuroprotective benefits and the risks, at short- and long-term outcome, of the antenatal administration of magnesium sulphate (MgSO4) in women at imminent risk of preterm delivery. MATERIAL AND METHODS: Computer databases Medline, the Cochrane Library and the recommendations of various international scientific societies. RESULTS: Given the demonstrated benefit of antenatal MgSO4 intravenous administration on the reduction of cerebral palsy rates and the improvement of motor development in children born preterm, it is recommended for all women whose imminent delivery is expected or programmed before 32 weeks of gestation (WG) (grade A)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28164440/effect-of-human-umbilical-cord-blood-mesenchymal-stem-cells-administered-by-intravenous-or-intravitreal-routes-on-cryo-induced-retinal-injury
#5
Eman M Mohamed, Shaimaa A Abdelrahman, Samia Hussein, Sally M Shalaby, Hala Mosaad, Ahmed M B Awad
Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure, apoptotic, antiapoptotic, oxidant and antioxidant markers in an experimental model of cryo-induced retinal damage in mice. Forty-eight mice were included with 4 major groups; group I contained 18 mice as controls...
February 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28163157/intranasal-immunization-with-novel-espa-tir-m-fusion-protein-induces-protective-immunity-against-enterohemorrhagic-escherichia-coli-o157-h7-challenge-in-mice
#6
Ruqin Lin, Bo Zhu, Yiduo Zhang, Yang Bai, Fachao Zhi, Beiguo Long, Yawen Li, Yuhua Wu, Xianbo Wu, Hongying Fan
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and hemolytic uremic syndrome in humans. Due to the risks associated with antibiotic treatment against EHEC O157:H7 infection, vaccines represent a promising method for prevention of EHEC O157:H7 infection. Therefore, we constructed the novel bivalent antigen EspA-Tir-M as a candidate EHEC O157:H7 subunit vaccine. We then evaluated the immunogenicity of this novel EHEC O157:H7 subunit vaccine. Immune responses to the fusion protein administered by intranasal and subcutaneous routes were compared in mice...
February 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28153801/on-the-determination-of-toxoplasma-gondii-virulence-in-mice
#7
REVIEW
Pooja Saraf, E Keats Shwab, Jitender P Dubey, Chunlei Su
Toxoplasma gondii is one of the most successful pathogens on earth, capable of infecting an extremely broad range of mammals and birds and causing potentially fatal disease in humans. The house mouse (Mus musculus) has been used as the primary laboratory animal model for determining the virulence of T. gondii strains. Epidemiological evidence also suggests a potential association between virulence in mice and disease severity in human toxoplasmosis. However, many factors can affect virulence measurements, including route of infection, life stage of the parasite, number of passages of the parasite in mice or cell culture, and the mouse host line used...
January 30, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28152045/comparative-analysis-of-sterol-acquisition-in-the-oomycetes-saprolegnia-parasitica-and-phytophthora-infestans
#8
Paul Dahlin, Vaibhav Srivastava, Sophia Ekengren, Lauren S McKee, Vincent Bulone
The oomycete class includes pathogens of animals and plants which are responsible for some of the most significant global losses in agriculture and aquaculture. There is a need to replace traditional chemical means of controlling oomycete growth with more targeted approaches, and the inhibition of sterol synthesis is one promising area. To better direct these efforts, we have studied sterol acquisition in two model organisms: the sterol-autotrophic Saprolegnia parasitica, and the sterol-heterotrophic Phytophthora infestans...
2017: PloS One
https://www.readbyqxmd.com/read/28147375/fecal-microbiota-transplantation-in-inflammatory-bowel-disease
#9
Walter Reinisch
The etiology of inflammatory bowel disease (IBD) is unknown, but it is thought to arise from an aberrant immune response to a change in colonic environment in a genetically susceptible individual. The intestinal microbiota are located at the complex interface of the epithelial barrier and are sensitive to changes in environmental factors, such as diets, drugs or smoking and signals derived from the intestinal immune system and the gut-brain axis. In patients with IBD, an imbalance in the structural and/or functional configuration of the intestinal microbiota leading to the disruption of the host-microorganism homeostasis (dysbiosis) has been reproducibly reported...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28143584/translationally-controlled-tumour-protein-tctp-is-induced-early-in-human-colorectal-tumours-and-contributes-to-the-resistance-of-hct116-colon-cancer-cells-to-5-fu-and-oxaliplatin
#10
Ulrich-Axel Bommer, Kara L Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead, Morteza Aghmesheh
BACKGROUND: Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protecting cancer cells against the cytotoxic action of anti-cancer drugs. Here we study the early increase of TCTP levels in human colorectal cancer (CRC) and the regulation of TCTP expression in HCT116 colon cancer cells, in response to treatment with the anti-cancer drugs 5-FU and oxaliplatin...
February 1, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28143569/a-large-outbreak-of-acute-gastroenteritis-caused-by-the-human-norovirus-gii-17-strain-at-a-university-in-henan-province-china
#11
Xue-Yong Huang, Jia Su, Qian-Chao Lu, Shi-Zheng Li, Jia-Yong Zhao, Meng-Lei Li, Yi Li, Xiao-Jing Shen, Bai-Fan Zhang, Hai-Feng Wang, Yu-Jiao Mu, Shu-Yu Wu, Yan-Hua Du, Li-Cheng Liu, Wei-Jun Chen, John David Klena, Bian-Li Xu
BACKGROUND: Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks. An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years. There was a large acute gastroenteritis outbreak at a university in Henan Province, China in the past five years. We want to identify the source, transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures...
February 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28134390/effects-of-surface-oxidation-of-cu-substrates-on-the-growth-kinetics-of-graphene-by-chemical-vapor-deposition
#12
Ren-Jie Chang, Chia-Hao Lee, Min-Ken Lee, Chun-Wei Chen, Cheng-Yen Wen
Although the success of graphene research has opened up a new route for wearable electronic and optoelectronic devices, producing graphene with controllable quality and cost-effective growth on a large scale remains challenging due to the lack of understanding about its growth kinetics. Domain boundaries interrupt lattice continuity of graphene; therefore, lowering the nucleation density at the initial stage of graphene growth in the chemical vapor deposition (CVD) process is beneficial for improving the quality of graphene for applications...
January 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/28131534/the-first-sixty-five-craniopharyngioma-operations-in-france
#13
REVIEW
I Castro-Dufourny, R Carrasco, R Prieto, L Barrios, J-M Pascual
Craniopharyngiomas (CPs) are benign epithelial tumors that develop along the hypothalamus-hypophyseal axis and were first described by Jakob Erdheim in 1904. These tumors have represented a challenge for surgeons since the rise of modern neurosurgery. The study of CPs is linked to the development of this surgical discipline in parallel with neuroendocrinology within the French school of neurology, led by Joseph Babinski. For the present study, all CP cases published in the French scientific literature before the development of modern neuroradiology were gathered, and 65 cases that underwent surgical procedures between 1921 and 1973 were selected...
January 25, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28110777/streptococcus-suis-small-rna-rss04-contributes-to-the-induction-of-meningitis-by-regulating-capsule-synthesis-and-by-inducing-biofilm-formation-in-a-mouse-infection-model
#14
Genhui Xiao, Huanyu Tang, Shouming Zhang, Haiyan Ren, Jiao Dai, Liying Lai, Chengping Lu, Huochun Yao, Hongjie Fan, Zongfu Wu
Streptococcus suis (SS) is an important pathogen for pigs, and it is also considered as a zoonotic agent for humans. Meningitis is one of the most common features of the infection caused by SS, but little is known about the mechanisms of SS meningitis. Recent studies have revealed that small RNAs (sRNAs) have emerged as key regulators of the virulence in several bacteria. In the previous study, we reported that SS sRNA rss04 was up-regulated in pig cerebrospinal fluid and contributes to SS virulence in a zebrafish infection model...
February 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28110538/deciphering-the-effect-of-polymer-assisted-doping-on-the-optoelectronic-properties-of-block-copolymer-anchored-graphene-oxide
#15
Nabasmita Maity, Atanu Kuila, Arun K Nandi
Doping facilitates the tuning of band gap, providing an opportunity to tailor the optoelectronic properties of graphene in a simple way, and polymer-assisted doping is a new route to combine the optoelectronic properties of graphene with the properties of a polymer. In this endeavor, a linear diblock copolymer, polycaprolactone-block-poly(dimethyl aminoethyl methacrylate) (PCL13-b-PDMAEMA117) (GPCLD) is grafted from the graphene oxide (GO) surface via consecutive ring opening and atom transfer radical polymerization...
February 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28098995/a-chemometrics-approach-to-the-investigation-of-the-intraspecific-variability-of-the-volatile-oil-of-eupatorium-tremulum-from-southern-brazil
#16
Tiago J T de Souza, Sérgio A L Bordignon, Miriam A Apel
Eupatorium tremulum is a South American shrub reported to cause cattle digestive intoxication, of which the volatile oil, mainly composed by bisabolane- and amorphane-type sesquiterpenoids, exhibits high quantitative variability. This report describes the application of chemometric tools for the identification of volatile compounds that characterize phenophasical changes in the plant. Preblooming, blooming, and postblooming specimens were paired-sampled and submitted to hydrodistillation and GC-MS analysis...
January 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28089914/arachidonic-acid-with-taurine-enhances-pulmonary-absorption-of-macromolecules-without-any-serious-histopathological-damages
#17
Masateru Miyake, Takanori Minami, Hiroyuki Yamazaki, Chie Emoto, Tadashi Mukai, Hajime Toguchi
Therapeutic peptides and protein are being used in several indications; however, their poor permeability still remains to be solved. This study focused on the pulmonary route of macromolecules. First, the effects of arachidonic acid (AA) as an absorption enhancer on drug serum concentration, after intratracheal administration, were investigated in rats. Second, the safety of AA was assessed in rats in an acute toxicity study for 7 days. AA enhanced the exposure of both interferon-α (IFN-α) and fluorescein isothiocyanate 4000 (FD-4)...
January 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28089549/modified-live-infectious-bursal-disease-virus-ibdv-vaccine-delays-infection-of-neonatal-broiler-chickens-with-variant-ibdv-compared-to-turkey-herpesvirus-hvt-ibdv-vectored-vaccine
#18
Shanika Kurukulasuriya, Khawaja Ashfaque Ahmed, Davor Ojkic, Thushari Gunawardana, Kalhari Goonewardene, Ashish Gupta, Betty Chow-Lockerbie, Shelly Popowich, Philip Willson, Suresh K Tikoo, Susantha Gomis
Chickens are commonly processed around 35-45days of age in broiler chicken industry hence; diseases that occur at a young age are of paramount economic importance. Early age infection with infectious bursal disease virus (IBDV) results in long-lasting immunosuppression and profound economic losses. To our knowledge, this is the first study comparing the protection efficacy of modified live (MdLV) IBDV and herpesvirus turkey (HVT)-IBDV vaccines against early age variant IBDV (varIBDV) infection in chicks. Experiments were carried out in IBDV maternal antibody (MtAb) positive chicks (n=330), divided into 6 groups (n=50-60/group), namely Group 1 (saline), Group 2 (saline+varIBDV), Group 3 (HVT-IBDV), Group 4 (HVT-IBDV+varIBDV), Group 5 (MdLV) and Group 6 (MdLV+varIBDV)...
January 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28088858/from-blue-to-green-fine-tuning-of-photoluminescence-and-electrochemiluminescence-in-bifunctional-organic-dyes
#19
Fabio Rizzo, Federico Polo, Gregorio Bottaro, Simona Fantacci, Sabrina Antonello, Lidia Armelao, Silvio Quici, Flavio Maran
We describe the synthesis, computational analysis, photophysics, electrochemistry and electrochemiluminescence (ECL) of a series of compounds formed of two triphenylamines linked by a fluorene or spirobifluorene bridge. The phenylamine moieties were modified at the para-position of the two external rings by electron-withdrawing or electron-donating substituents. These modifications allowed for fine-tuning of the photoluminescence (PL) and ECL emission from blue to green, with an overall wavelength span of 73 (PL) and 67 (ECL) nm, respectively...
January 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28081235/comprehensive-rna-seq-profiling-to-evaluate-the-sheep-mammary-gland-transcriptome-in-response-to-experimental-mycoplasma-agalactiae-infection
#20
Rohini Chopra-Dewasthaly, Melanie Korb, René Brunthaler, Reinhard Ertl
Mycoplasma agalactiae is a worldwide serious pathogen of small ruminants that usually spreads through the mammary route causing acute to subacute mastitis progressing to chronic persistent disease that is hard to eradicate. Knowledge of mechanisms of its pathogenesis and persistence in the mammary gland are still insufficient, especially the host-pathogen interplay that enables it to reside in a chronic subclinical state. This study reports transcriptome profiling of mammary tissue from udders of sheep experimentally infected with M...
2017: PloS One
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