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https://www.readbyqxmd.com/read/28423108/-potential-health-risks-from-consumption-of-water-with-arsenic-in-colima-mexico
#1
Oliver Mendoza-Cano, Ramón Alberto Sánchez-Piña, Julián Barrón-Quintana, Herguin Benjamin Cuevas-Arellano, Pilar Escalante-Minakata, Ramón Solano-Barajas
Objective: To estimate potential health risks due to chronic ingestion of arsenic from groundwater in Colima, Mexico. Materials and methods: Samples were randomly taken in 36 wells from 10 local aquifers. Analysis was performed by ICP-OES following international standards. Geostatistical interpolation was performed with ArcGIS, implementing a model weighting inverse distance to estimate arsenic routes of exposure and consumption on each locality. The Hazard Quotient Ratio (HQ) and carcinogenic risk (R) for As were estimated...
January 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28416382/isolation-pathogenicity-and-characterization-of-a-novel-bacterial-pathogen-streptococcus-uberis-from-diseased-mandarin-fish-siniperca-chuatsi
#2
Xia Luo, Xiaozhe Fu, Guoli Liao, Ouqin Chang, Zhibin Huang, Ningqiu Li
In recent years, mandarin fish had a high mortality rate associated with abnormal swimming, exophthalmia, corneal opacity and eye hemorrhage on a fish farm located at Foshan city, Guangdong province, China. Three isolates of Gram-positive, chain-forming cocci were recovered from moribund fish, and designated as SS131025-1, SS131025-2, and SS131025-3. These isolates were identified as Streptococcus uberis according to their morphologic and physio-biochemical characteristics as well as phylogenetic analysis based on their 16S rRNA and GapC gene sequences...
April 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28415051/cross-interference-of-two-model-peroxisome-proliferators-in-peroxisomal-and-estrogenic-pathways-in-brown-trout-hepatocytes
#3
Tânia Vieira Madureira, Ivone Pinheiro, Fernanda Malhão, Célia Lopes, Ralph Urbatzka, L Filipe C Castro, Eduardo Rocha
Peroxisome proliferators cause species-specific effects, which seem to be primarily transduced by peroxisome proliferator-activated receptor alpha (PPARα). Interestingly, PPARα has a close interrelationship with estrogenic signaling, and this latter has already been promptly activated in brown trout primary hepatocytes. Thus, and further exploring this model, we assess here the reactivity of two PPARα agonists in direct peroxisomal routes and, in parallel the cross-interferences in estrogen receptor (ER) mediated paths...
April 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28412507/transcriptomic-analyses-of-human-bronchial-epithelial-cells-beas-2b-exposed-to-atmospheric-fine-particulate-matter-pm2-5
#4
Yang Li, Junchao Duan, Man Yang, Yanbo Li, Li Jing, Yang Yu, Ji Wang, Zhiwei Sun
Respiratory exposure is the major route of atmospheric PM2.5 entering the human body. Epidemiological studies have indicated that exposure to PM2.5 is associated with increased risk of pulmonary diseases, but the underlying mechanisms remain less clear. In this study, human bronchial epithelial cells (BEAS-2B) were used to investigate the toxic effect and gene expression changes induced by PM2.5 collected from Beijing, China, based on microarray and following bioinformatic analyses. Gene ontology (GO) analysis indicated that PM2...
April 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28403561/iron-deficiency-anemia-in-chronic-kidney-disease-uncertainties-and-cautions
#5
Rajiv Agarwal
Anemia in chronic kidney disease is common and iron deficiency is an important cause. To repair iron-deficiency anemia, replacement of iron is needed. Iron can be replaced either by the oral route or by the intravenous route. In a meta-analysis, 5 of the 6 trials were short-term, 1 to 3 months, and compared to oral iron, the mean increase in hemoglobin with intravenous iron was only 0.31 g/dL. However, one of the studies included in this meta-analysis was 6 months long and had a mean decline in hemoglobin of 0...
April 12, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28400558/a-universal-primer-independent-next-generation-sequencing-approach-for-investigations-of-norovirus-outbreaks-and-novel-variants
#6
Jannik Fonager, Marc Stegger, Lasse Dam Rasmussen, Mille Weismann Poulsen, Jesper Rønn, Paal Skytt Andersen, Thea Kølsen Fischer
Norovirus (NoV) is the most common cause of non-bacterial gastroenteritis and is a major agent associated with outbreaks of gastroenteritis. Conventional molecular genotyping analysis of NoV, used for the identification of transmission routes, relies on standard typing methods (STM) by Sanger-sequencing of only a limited part of the NoV genome, which could lead to wrong conclusions. Here, we combined a NoV capture method with next generation sequencing (NGS), which increased the proportion of norovirus reads by ~40 fold compared to NGS without prior capture...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376875/tgfbr2-dependent-alterations-of-exosomal-cargo-and-functions-in-dna-mismatch-repair-deficient-hct116-colorectal-cancer-cells
#7
Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz, Johannes Gebert
BACKGROUND: Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA sequences (microsatellites). These tumors recurrently show inactivating frameshift mutations in the tumor suppressor Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) thereby abrogating downstream signaling. How altered TGFBR2 signaling affects exosome-mediated communication between MSI tumor cells and their environment has not been resolved...
April 4, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28374636/project-safefoodpack-design-case-study-indirect-migration-from-paper-and-boards
#8
Phuong-Mai Nguyen, Jean Mario Julien, Colette Breysse, Cédric Lyathaud, Jacques Thébault, Olivier Vitrac
Migration due to indirect contact with packaging caused several major sanitary crises, including the spread contamination of dry food by mineral oils and printing ink constituents from cardboard. The issues are still not fully resolved because the mechanisms have been insufficiently described and the relationship between design, the contamination level, the type of contaminant, the conditions of storage (time and temperature) are poorly understood. This study proposes a forensic analysis of these phenomena, when food is separated from cardboard by a plastic layer...
April 4, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28371563/placental-stromal-cell-therapy-for-experimental-autoimmune-encephalomyelitis-the-role-of-route-of-cell-delivery
#9
Ilona Shapira, Nina Fainstein, Maria Tsirlin, Ilana Stav, Evgenia Volinsky, Claudia Moresi, Tamir Ben-Hur, Raphael Gorodetsky
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) with no effective treatment available for the chronic-progressive stage. Cell therapy is a promising therapeutic approach for attenuating the immune-mediated CNS process. Isolated and expanded human placental stromal cells (hPSCs) possess potent immunomodulatory and trophic properties, making them a good candidate for MS therapy. We examined the potential of hPSC therapy in preventing the onset or attenuating the course of established disease in a murine MS model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28369303/transaortic-transcatheter-aortic-valve-implantation-as-a-first-line-choice-or-as-a-last-resort-an-analysis-based-on-the-route-registry
#10
Nikolaos Bonaros, Rainer Petzina, Riccardo Cocchieri, Dariusz Jagielak, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Vinayak Bapat, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Hardy Baumbach, Markus Kofler, Peter Bramlage, Cornelia Deutsch, Martin Thoenes, Derk Frank, Mauro Romano
OBJECTIVES: Transaortic transcatheter aortic valve implantation (TAo-TAVI) is a recently developed alternative to transapical (TA) or transfemoral (TF) TAVI. We aimed to analyse the effectiveness and safety of TAo-TAVI as a first line approach and to compare it to patients receiving TAo-TAVI as a last resort, which is current practice. METHODS: ROUTE is a prospective, multicentre registry to assess the clinical outcomes of TAo-TAVI. Patients without contraindications for TA- and TF-TAVI (TAo-first) were compared to patients with contraindications for both of these access routes (TAo-last)...
May 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28363959/microbiota-analysis-of-environmental-slurry-and-its-potential-role-as-a-reservoir-of-bovine-digital-dermatitis-pathogens
#11
Kirstine Klitgaard, Mikael L Strube, Anastasia Isbrand, Tim K Jensen, Martin W Nielsen
At present, very little information exists regarding what role the environmental slurry may play as an infection reservoir and/or route of transmission for bovine digital dermatitis (DD), a disease which is a global problem in dairy herds. To investigate, if DD-related bacteria belong to the indigenous microbiota of the dairy herd environment, we used deep amplicon sequencing of the 16S rRNA gene in 135 slurry samples collected from different sites in 22 dairy farms, with and without DD-infected cows. Both the general bacterial populations as well as digital dermatitis-associated Treponema were targeted in this study...
March 31, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28362945/complex-routes-of-nosocomial-vancomycin-resistant-enterococcus-faecium-transmission-revealed-by-genome-sequencing
#12
Kathy E Raven, Theodore Gouliouris, Hayley Brodrick, Francesc Coll, Nicholas M Brown, Rosy Reynolds, Sandra Reuter, M Estée Török, Julian Parkhill, Sharon J Peacock
Background: Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of nosocomial infection. Here, we describe the utility of whole-genome sequencing in defining nosocomial VREfm transmission. Methods: A retrospective study at a single hospital in the United Kingdom identified 342 patients with E. faecium bloodstream infection over 7 years. Of these, 293 patients had a stored isolate and formed the basis for the study. The first stored isolate from each case was sequenced (200 VREfm [197 vanA, 2 vanB, and 1 isolate containing both vanA and vanB], 93 vancomycin-susceptible E...
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28362140/occurrence-of-giardia-in-swedish-red-foxes-vulpes-vulpes
#13
John J Debenham, Hanne Landuyt, Karin Troell, Kristoffer Tysnes, Lucy J Robertson
Giardia duodenalis is an intestinal protozoan capable of causing gastrointestinal disease in a range of vertebrate hosts. It is transmitted via the fecal-oral route. Understanding the epidemiology of G. duodenalis in animals is important, both for public health and for the health of the animals it infects. We investigated the occurrence of G. duodenalis in wild Swedish red foxes ( Vulpes vulpes ), with the aim of providing preliminary information on how this abundant predator might be involved in the transmission and epidemiology of G...
March 31, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28347521/-detection-and-early-treatment-of-subjects-at-high-risk-of-clinical-psychosis-definitions-and-recommendations
#14
C Michel, E Toffel, S J Schmidt, S Eliez, M Armando, A Solida-Tozzi, F Schultze-Lutter, M Debbané
In children and adolescents, psychotic disorders already represent one of the leading causes of disability-adjusted life years. During the past two decades, early detection of risk for psychosis has been intensively investigated, and in particular, predictive power for early signs of risk has been initiated and translated into clinical practice. In particular, the attenuated and transient positive symptoms of the ultra-high risk criteria, and the basic symptom criterion "cognitive disturbances", open promising routes to an indicated prevention and have recently been considered by the European Psychiatric Association (EPA) as diagnostic criteria of a psychosis-risk syndrome...
March 24, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28346094/drug-library-screening-for-the-identification-of-ionophores-that-correct-the-mistrafficking-disorder-associated-with-oxalosis-kidney-disease
#15
Shurong Hou, Franck Madoux, Louis Scampavia, Jo Ann Janovick, P Michael Conn, Timothy P Spicer
Primary hyperoxaluria is the underlying cause of oxalosis and is a life-threatening autosomal recessive disease, for which treatment may require dialysis or dual liver-kidney transplantation. The most common primary hyperoxaluria type 1 (PH1) is caused by genetic mutations of a liver-specific enzyme alanine:glyoxylate aminotransferase (AGT), which results in the misrouting of AGT from the peroxisomes to the mitochondria. Pharmacoperones are small molecules with the ability to modify misfolded proteins and route them correctly within the cells, which may present an effective strategy to treat AGT misrouting in PH1 disorders...
January 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28345751/tsunami-evacuation-buildings-and-evacuation-planning-in-banda-aceh-indonesia
#16
Hendri Yuzal, Karl Kim, Pradip Pant, Eric Yamashita
Indonesia, a country of more than 17,000 islands, is exposed to many hazards. A magnitude 9.1 earthquake struck off the coast of Sumatra, Indonesia, on December 26, 2004. It triggered a series of tsunami waves that spread across the Indian Ocean causing damage in 11 countries. Banda Aceh, the capital city of Aceh Province, was among the most damaged. More than 31,000 people were killed. At the time, there were no early warning systems nor evacuation buildings that could provide safe refuge for residents. Since then, four tsunami evacuation buildings (TEBs) have been constructed in the Meuraxa subdistrict of Banda Aceh...
January 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28344493/volatile-constituents-and-biological-activities-of-the-leaf-and-root-of-echinacea-species-from-south-africa
#17
M Nyalambisa, I A Oyemitan, R Matewu, O O Oyedeji, O S Oluwafemi, S P Songca, B N Nkeh-Chungag, A O Oyedeji
Echinacea is used ethnomedicinally for the treatment of various diseases such as cough, respiratory infections, and bronchitis among other uses in Eastern Cape region of South Africa. This study evaluated the volatile components of the essential oil of the plant, its toxicity, anti-inflammatory and analgesic activities in rodents. Dried leaf and root of the plant were separately processed by hydrodistillation for 4 h and their essential oils (EOs) were collected. Extracted oils were subjected to GC/GC-MS analysis...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28341546/co-circulation-of-two-usutu-virus-strains-in-northern-italy-between-2009-and-2014
#18
Mattia Calzolari, Chiara Chiapponi, Paolo Bonilauri, Davide Lelli, Laura Baioni, Ilaria Barbieri, Antonio Lavazza, Stefano Pongolini, Michele Dottori, Ana Moreno
Usutu virus is an arbovirus closely related to West Nile virus (genus Flavivirus), which circulates between mosquitoes and wild birds. This virus has been increasingly reported in Europe, raising concerns for its possible pathogenic potential for wild birds and humans. This study reports the whole genome sequences of 15 strains of USUV, isolated between 2010 and 2014 from mosquitoes and wild birds in the course of West Nile virus surveillance in the Emilia-Romagna and Lombardy regions of Northern Italy. Both whole and 656 partial genome sequences, obtained from isolated viruses and field samples (mosquitoes and wild birds), were analyzed to describe the temporal and geographical spread of USUV in the surveyed area...
March 22, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28339472/vector-status-of-aedes-species-determines-geographical-risk-of-autochthonous-zika-virus-establishment
#19
Lauren Gardner, Nan Chen, Sahotra Sarkar
BACKGROUND: The 2015-16 Zika virus pandemic originating in Latin America led to predictions of a catastrophic global spread of the disease. Since the current outbreak began in Brazil in May 2015 local transmission of Zika has been reported in over 60 countries and territories, with over 750 thousand confirmed and suspected cases. As a result of its range expansion attention has focused on possible modes of transmission, of which the arthropod vector-based disease spread cycle involving Aedes species is believed to be the most important...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28336494/minocycline-reduces-inflammatory-parameters-in-the-brain-structures-and-serum-and-reverses-memory-impairment-caused-by-the-administration-of-amyloid-%C3%AE-1-42-in-mice
#20
Michelle Lima Garcez, Francielle Mina, Tatiani Bellettini-Santos, Franciellen Gonçalves Carneiro, Aline Pereira Luz, Gustavo Luis Schiavo, Matheus Scopel Andrighetti, Maylton Grégori Scheid, Renan Pereira Bolfe, Josiane Budni
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common type of age-related dementia. Cognitive decline, beta-amyloid (Aβ) accumulation, neurofibrillary tangles, and neuroinflammation are the main pathophysiological characteristics of AD. Minocycline is a tetracycline derivative with anti-inflammatory properties that has a neuroprotective effect. The aim of this study was to evaluate the effect of minocycline on memory, neurotrophins and neuroinflammation in an animal model of AD induced by the administration of Aβ (1-42) oligomer...
March 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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