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https://www.readbyqxmd.com/read/29142562/drug-poisoning-and-associated-factors-in-western-saudi-arabia-a-five-year-retrospective-chart-review-2011-2016
#1
Sami H Alzahrani, Ali H Alqahtani, Fayssal Mostafa Farahat, Mohammed Abdel Galil Elnour, Jamil Bashawri
Objective: Drug poisoning is a globally common cause of emergency-room admissions. This study explores drug-poisoning prevalence patterns, associated risk factors (gender, age and exposure circumstances), and outcomes in western Saudi Arabia. Methods: Retrospective analysis of Clinical drug poisoning cases (2011-2016). The data were retrieved from the Saudi Ministry of Health's record and Patients' medical charts were analyzed. Results: The Ministry of Health received 1,474 reports of drug poisoning during 2011-2016...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142416/protective-effect-of-pluchea-lanceolata-against-aluminum-chloride-induced-neurotoxicity-in-swiss-albino-mice
#2
Ravi Mundugaru, Senthilkumar Sivanesan, Padmaja Udaykumar, Niranjan Rao, Naveen Chandra
Background: Aluminum chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in the brain. The herb Pluchea lanceolata is commonly known as "Rasana" and used as a nerve tonic in neuroinflammatory conditions in Indian system of medicine. Objective: To evaluate the neuroprotective activity of hydroalcoholic extract of P. lanceolata in chronic AlCl3-induced neurotoxicity in Swiss albino mice. Materials and Methods: Albino mice were categorized into four different groups; Group 1served as vehicle control, Group 2 mice were administered with AlCl3, 40 mg/kg body weight by intraperitoneal route for 45 consecutive days...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137243/ionising-radiation-increases-permeability-of-endothelium-through-adam10-mediated-cleavage-of-ve-cadherin
#3
Sylwia Kabacik, Ken Raj
The association between ionising radiation (IR) exposure and risk of cardiovascular diseases (CVD) is well documented, but the underlying mechanism is still poorly understood. As atherosclerotic plaques are the most common cause of CVD, we investigated the effects of IR on one of the critical parameters for atherosclerotic plaque formation - endothelium permeability to macromolecules. We used endothelial cells from human coronary artery as a model of the endothelial layer. Our results show that exposure of this endothelial layer to IR increased its permeability to macromolecules of various sizes in a dose-dependent manner...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29130769/neuroprotective-effects-and-uplc-q-tof-ms-based-active-components-identification-of-external-applied-a-novel-wen-luo-tong-microemulsion
#4
Hong-Mei Lin, Long-Fei Lin, Zhen-Zhen Xia, Yong Mao, Jia Liu, Ling-Yan Xu, Qing Wu
Chemotherapy induced neuropathy causes excruciating pain to cancer patients. Wen-Luo-Tong (WLT), a traditional Chinese medicinal compound, has been used to alleviate anti-cancer drug such as oxaliplatin-induced neuropathic pain for many years. However, the current route of administration of WLT is inconvenient and the active ingredients and mechanism of action of WLT are still unclear. To address these issues, we developed a novel formulation of WLT (W/O microemulsion) for the ease of application. New ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) methods were employed for analysis of the ingredients...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29126978/toxoplasma-gondii-seroprevalence-in-goats-cats-and-humans-in-russia
#5
Eduard A Shuralev, Nikolai D Shamaev, Malik N Mukminov, Kisaburo Nagamune, Yuji Taniguchi, Taizo Saito, Katsuya Kitoh, Marina I Arleevskaya, Anastasiya Yu Fedotova, Diana R Abdulmanova, Natalya M Aleksandrova, Marina A Efimova, Aynur I Yarullin, Anna R Valeeva, Kamil S Khaertynov, Yasuhiro Takashima
Toxoplasmosis, a most common zoonosis, is caused by the protozoan parasite Toxoplasma gondii. However, there is little epidemiological information on T. gondii infections in humans and livestock animals in Russia. Therefore, in this study, the seroprevalence of T. gondii in goats in Russia was investigated. A total of 216 goats from 32 farms were investigated and 95 of them were seropositive for T. gondii. The difference in seroprevalence between the examined regions was not statistically significant. We next collected serum samples from 99 cats and 181 humans in Kazan city, the state capital of the Republic of Tatarstan, Russia, and examined their T...
November 7, 2017: Parasitology International
https://www.readbyqxmd.com/read/29116002/ice-associated-norovirus-outbreak-predominantly-caused-by-gii-17-in-taiwan-2015
#6
Hao-Yuan Cheng, Min-Nan Hung, Wan-Chin Chen, Yi-Chun Lo, Ying-Shih Su, Hsin-Yi Wei, Meng-Yu Chen, Yen-Chang Tuan, Hui-Chen Lin, Hsu-Yang Lin, Tsung-Yen Liu, Yu-Ying Wang, Fang-Tzy Wu
BACKGROUND: On 5 March 2015, Taiwan Centers for Disease Control was notified of more than 200 students with gastroenteritis at a senior high school during excursion to Kenting. We conducted an outbreak investigation to identify the causative agent and possible vehicle of the pathogen. METHODS: We conducted a retrospective cohort study by using a structured questionnaire to interview all students for consumed food items during their stay at the resort. Students were defined as a gastroenteritis case while having vomiting or diarrhea after the breakfast on 4 March...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29107028/toxic-equivalency-factors-tefs-after-acute-oral-exposure-of-azaspiracid-1-2-and-3-in-mice
#7
M Pelin, J Kilcoyne, C Nulty, S Crain, P Hess, A Tubaro, S Sosa
Azaspiracids (AZAs) are marine algal toxins that can be accumulated by edible shellfish to cause a foodborne gastrointestinal poisoning in humans. In the European Union, only AZA1, -2 and -3 are currently regulated and their concentration in shellfish is determined through their toxic equivalency factors (TEFs) derived from the intraperitoneal lethal potency in mice. Nevertheless, considering the potential human exposure by oral route, AZAs TEFs should be calculated by comparative oral toxicity data. Thus, the acute oral toxicity of AZA1, -2 and -3 was investigated in female CD-1 mice treated with different doses (AZA1: 135-1100μg/kg; AZA2 and AZA3: 300-1100μg/kg) and sacrificed after 24h or 14days...
November 6, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29104752/combined-analysis-of-the-safety-of-intra-coronary-drug-delivery-during-primary-percutaneous-coronary-intervention-for-acute-myocardial-infarction-a-study-of-three-clinical-trials
#8
Krishnaraj S Rathod, Stephen Hamshere, Rayomand S Khambata, Mervyn Andiapen, Mark Westwood, Anthony Mathur, Amrita Ahluwalia, Daniel A Jones
Background: The local injection of novel cardioprotective study drugs prior to percutaneous coronary intervention could cause embolisation of thrombus, resulting in increased reperfusion injury and subsequent infarct size. The aim of this study was to assess the safety of the delivery of an intracoronary therapy delivered during primary percutaneous coronary intervention for acute myocardial infarction prior to the re-establishment of thrombolysis in myocardial infarction III flow. Methods: One hundred sixty-seven patients with acute myocardial infarction successfully reperfused through primary percutaneous coronary intervention and undergoing Cardiac MRI within the first week after reperfusion were studied...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29103063/the-effect-of-biological-rhythms-and-personality-traits-on-the-incidence-of-unsafe-behaviors-among-bus-drivers-in-shiraz-iran
#9
Fatemeh Kamari Ghanavati, Mehdi Jahangiri, Maryam Khalifeh, Sareh Keshavarzi, Mahnaz Shakerian
BACKGROUND: Unsafe behaviors are main causes of accidents mostly influenced by personal characteristics, social environment and also individual biorhythm cycles. This study was carried out to find out whether personality traits and biorhythm could affect the incidence of unsafe behaviors among city bus drivers. METHODS: This cross-sectional study was conducted on 224 bus drivers in Shiraz, Iran, 2014. The data were collected using NEO personality traits questionnaire...
November 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/29102894/effect-of-nitrogen-on-the-microstructure-and-mechanical-properties-of-co-33cr-9w-alloys-prepared-by-dental-casting
#10
Kenta Yamanaka, Manami Mori, Yasuhiro Torita, Akihiko Chiba
The effect of nitrogen concentration on the mechanical properties of Co-33Cr-9W alloy dental castings fabricated using the "high-Cr and high-N" concept was investigated. Microstructural analysis was performed on the alloys, and findings were discussed in relation to the mechanical properties. Owing to their high nitrogen concentrations (0.25-0.35wt%), all alloys prepared exhibited face-centered cubic (fcc) γ-phase matrices with a-few-millimeter grains consisting of dendritic substructures. Strain-induced martensitic transformations to produce hexagonal close-packed (hcp) ε-phases were not identified under tensile deformation...
October 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29100529/vaccine-related-poliovirus-shedding-in-trivalent-polio-vaccine-and-human-immunodeficiency-virus-status-analysis-from-under-five-children
#11
Joanne Hassan, Laura Wangai, Peter Borus, Christopher Khayeka-Wandabwa, Lucy Wanja Karani, Mercy Kithinji, Michael Kiptoo
BACKGROUND: Poliomyelitis is an acute viral infection caused by poliovirus and transmitted via the fecal-oral route. The causative agent is one of the three serotypes of poliovirus (serotypes 1, 2, 3) that differ slightly in capsid protein. Prolonged vaccine-related poliovirus shedding in human immunodeficiency virus (HIV) positive individuals has been linked to possible reservoir for reintroduction of polioviruses after eradication. The study therefore aimed at estimating the duration for vaccine-related poliovirus shedding among potentially and HIV-infected persons...
November 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29099543/vitamin-d-supplementation-for-chronic-liver-diseases-in-adults
#12
REVIEW
Goran Bjelakovic, Dimitrinka Nikolova, Marko Bjelakovic, Christian Gluud
BACKGROUND: Vitamin D deficiency is often reported in people with chronic liver diseases. Therefore, improving vitamin D status could have a beneficial effect on people with chronic liver diseases. OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation in people with chronic liver diseases. SEARCH METHODS: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Science Citation Index Expanded, and Conference Proceedings Citation Index - Science...
November 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29091957/hepatitis-e-virus-hev-egress-role-of-bst2-tetherin-and-interferon-induced-long-non-coding-rna-lncrna-bispr
#13
Daizy Paliwal, Prashant Joshi, Subrat Kumar Panda
BACKGROUND: The biology of Hepatitis E Virus (HEV), a common cause of epidemic and sporadic hepatitis, is still being explored. HEV exits liver through bile, a process which is essential for its natural transmission by feco-oral route. Though the process of this polarised HEV egress is not known in detail, HEV pORF3 and hepatocyte actin cytoskeleton have been shown to play a role. METHODS: Our transcriptome analysis in Hepatitis E virus (HEV) replicon transfected Huh7 cells at 24 and 72 hrs indicated that at 24hrs, both LncBISPR and BST2, expressed by a bidirectional promoter were highly upregulated whereas at 72 hrs, BST2 expression was comparatively reduced accompanied by normal levels of BISPR...
2017: PloS One
https://www.readbyqxmd.com/read/29082412/the-biodistribution-excretion-and-potential-toxicity-of-different-sized-pd-nanosheets-in-mice-following-oral-and-intraperitoneal-administration
#14
Xiaolan Chen, Jingchao Li, Yizhuan Huang, Jingping Wei, Duo Sun, Nanfeng Zheng
Two-dimensional (2D) Pd-based nanomaterials with strong near-infrared absorption have recently shown great application prospects in cancer diagnosis and therapy. Most previous studies mainly focused on understanding the in vivo behaviors and treatment effects of these Pd-based nanomaterials after intravenous injection into mice. However, it remains unclear whether other administration routes will affect the in vivo biodistribution, excretion and potential toxicity of Pd-based nanomaterials. In this study, for the first time we systematically explored the in vivo behaviors of different-sized Pd nanosheets (NSs) (approximately 5 nm, 30 nm and 80 nm) following oral feeding and intraperitoneal injection...
October 30, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29073919/a-review-of-virulent-newcastle-disease-viruses-in-the-united-states-and-the-role-of-wild-birds-in-viral-persistence-and-spread
#15
REVIEW
Vienna R Brown, Sarah N Bevins
Newcastle disease is caused by virulent strains of Newcastle disease virus (NDV), which causes substantial morbidity and mortality events worldwide in poultry. The virus strains can be differentiated as lentogenic, mesogenic, or velogenic based on a mean death time in chicken embryos. Currently, velogenic strains of NDV are not endemic in United States domestic poultry; however, these strains are present in other countries and are occasionally detected in wild birds in the U.S. A viral introduction into domestic poultry could have severe economic consequences due to the loss of production from sick and dying birds, the cost of control measures such as depopulation and disinfection measures, and the trade restrictions that would likely be imposed as a result of an outbreak...
October 26, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29065126/giardiasis-as-a-neglected-disease-in-brazil-systematic-review-of-20-years-of-publications
#16
Camila Henriques Coelho, Maurício Durigan, Diego Averaldo Guiguet Leal, Adriano de Bernardi Schneider, Regina Maura Bueno Franco, Steven M Singer
INTRODUCTION: Giardiasis is an intestinal infection that affects more than two hundred million people annually worldwide; it is caused by the flagellated protozoan Giardia duodenalis. In tropical countries and in low or middle-income settings, like Brazil, its prevalence can be high. There is currently no systematic review on the presence of G. duodenalis in patients, animals or water sources in Brazil. METHODS: This systematic review was performed according to recommendations established by Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29061347/reactogenicity-and-safety-assessment-of-an-attenuated-nanovaccine-against-scorpion-envenomation-preclinical-study
#17
Faez Amokrane Nait Mohamed, Abdelmounaim Nouri, Fatima Laraba-Djebari
An attenuated nanovaccine (Nps - V(∗)) has been developed to protect humans from fatal scorpion envenomation in at-risk regions. This study was conducted to evaluate the toxicity and the local reactogenicity of the Nps - V(∗) nanovaccine developed against Androctonus australis hector (Aah) venom. Assessment of the systemic inflammatory response and serum cytokine levels were evaluated in vaccinated mice with 100μg of irradiated Aah venom (V(∗)) encapsulated or not into polymeric calcium-alginate nanoparticles (Nps) and injected by subcutaneous (s...
October 20, 2017: Vaccine
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#18
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29044712/inferring-the-geographic-origin-of-a-range-expansion-latitudinal-and-longitudinal-coordinates-inferred-from-genomic-data-in-an-abc-framework-with-the-program-x-origin
#19
Qixin He, Joyce R Prado, L Lacey Knowles
Climatic or environmental change is not only driving distributional shifts in species today, but it has also caused distributions to expand and contract in the past. Inferences about the geographic locations of past populations, especially regions that served as refugia (i.e., source populations) and migratory routes are a challenging endeavor. Refugial areas may be evidenced from fossil records or regions of temporal stability inferred from ecological niche models. Genomic data offer an alternative and broadly applicable source of information about the locality of refugial areas, especially relative to fossil data, which are either unavailable or incomplete for most species...
October 16, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29033504/procedural-characteristics-and-outcomes-of-transcatheter-aortic-valve-implantation-a-single-center-experience-of-the-first-100-inoperable-or-high-surgical-risk-patients-with-severe-aortic-stenosis
#20
Ying-Hwa Chen, Hsiao-Huang Chang, Po-Lin Chen, Zen-Chung Weng, I-Ming Chen, Hsin-Bang Leu, Chun-Yang Huang, Su-Man Lin, Mei-Han Wu
BACKGROUND: This is the first study of a Taiwanese population reporting transcatheter aortic valve implantation (TAVI) outcomes of the first 100 cases from a single center offering two different transcatheter heart valve technologies via six types of approaches. We herein report the 30-day and one-year outcomes in our first 100 TAVI patients at Taipei Veterans General Hospital. METHODS: From May 2010 to April 2016, 100 consecutive patients with severe aortic stenosis (AS) who were considered unsuitable or at high risk for surgical aortic valve replacement underwent TAVI...
July 2017: Acta Cardiologica Sinica
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