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Cardiovascular complications of Diabetes mellitus

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https://www.readbyqxmd.com/read/29784563/limited-benefit-of-haemoglobin-glycation-index-as-risk-factor-for-cardiovascular-disease-in-type-2-diabetes-patients
#1
H B Østergaard, T Mandrup-Poulsen, G F N Berkelmans, Y van der Graaf, F L J Visseren, J Westerink
BACKGROUND: The haemoglobin glycation index (HGI) has been proposed as a marker of interindividual differences in haemoglobin glycosylation. Previous studies have shown a relationship between high HGI and risk of cardiovascular disease (CVD) in patients with diabetes. However, no studies have investigated the role of previous CVD in this association. METHODS: The study cohort comprised patients with type 2 diabetes mellitus (T2DM; n=1910) included in the Second Manifestations of Arterial Disease (SMART) study...
May 8, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29784059/diabetes-intervention-accentuating-diet-and-enhancing-metabolism-diadem-i-a-randomised-controlled-trial-to-examine-the-impact-of-an-intensive-lifestyle-intervention-consisting-of-a-low-energy-diet-and-physical-activity-on-body-weight-and-metabolism-in-early
#2
Shahrad Taheri, Odette Chagoury, Hadeel Zaghloul, Sara Elhadad, Salma Hayder Ahmed, Omar Omar, Sherryl Payra, Salma Ahmed, Neda El Khatib, Rasha Abou Amona, Katie El Nahas, Matthew Bolton, Henem Chaar, Noor Suleiman, Amin Jayyousi, Mahmoud Zirie, Ibrahim Janahi, Wahiba Elhag, Abdulla Alnaama, Abduljaleel Zainel, Dahlia Hassan, Tim Cable, Mary Charlson, Martin Wells, Abdulla Al-Hamaq, Samya Al-Abdulla, Abdul Badi Abou-Samra
BACKGROUND: Type 2 diabetes mellitus (T2DM) and obesity are syndemic and will have a significant impact on affected individuals and healthcare services worldwide. Evidence shows that T2DM remission can be achieved with significant weight loss in those who are younger with early diabetes and requiring fewer medications for glycaemic control. DIADEM-I aims to examine the impact of an intensive lifestyle intervention (ILI) using a low-energy diet (LED) meal replacement approach combined with physical activity in younger individuals with early T2DM...
May 21, 2018: Trials
https://www.readbyqxmd.com/read/29783249/prognosis-of-ischaemic-heart-disease-in-patients-with-newly-diagnosed-dm-type-2-by-logistic-regression
#3
Alina Urbanovych, Halyna Suslyk
OBJECTIVE: Introduction: Diabetes Mellitus (DM) type 2 is an important medical and social problem all around the world. One of the most serious and widespread complications of DM type 2 is a damage to the cardiovascular system. The aim was to study the way of how to predict the IHD development in patients with the newly diagnosed DM type 2 by building a mathematical model with the help of statistical method, in particular, a logistic regression, which allows predicting the occurrence of IHD by the levels of proven biochemical and anthropometric indices...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780358/sex-and-gender-differences-in-prevention-of-type-2-diabetes
#4
REVIEW
Jürgen Harreiter, Alexandra Kautzky-Willer
Lifestyle intervention programs are effective in the prevention of type 2 diabetes mellitus (T2DM) in high risk populations. However, most studies only give limited information about the influence of sex and/or gender effectiveness of these interventions. So far, similar outcome was reported for diabetes progression and weight loss. Nevertheless, long-term data on cardiovascular outcome are sparse but favoring women regarding all-cause and cardiovascular mortality. In both men and women, sex hormone imbalances and reproductive disorders are associated with a higher risk of T2DM development...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29764908/management-of-endocrine-disease-which-metabolic-procedure-comparing-outcomes-in-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#5
Adrian T Billeter, Javier de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat Müller-Stich
Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss...
May 15, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29764436/prevalence-and-incidence-of-complications-at-diagnosis-of-t2dm-and-during-follow-up-by-bmi-and-ethnicity-a-matched-case-control-analysis
#6
Ebenezer S Owusu Adjah, Srikanth Bellary, Wasim Hanif, Kiran Patel, Kamlesh Khunti, Sanjoy K Paul
AIMS: To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and South Asian (SA) patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Patients with new diagnosis of T2DM, aged ≥ 18 years from January 2000 (n = 69,436) and their age-sex-ethnicity matched non-diabetic controls (n = 272,190) were identified from UK primary care database...
May 15, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29763911/clinical-correlates-of-ambulatory-blood-pressure-phenotypes-at-a-tertiary-care-hospital-in-turkey
#7
Siyar Erdogmus, Sim Kutlay, Zeynep Kendi Celebi, Tolga Aydın, Damla Ors Sendogan, Gizem Kumru, Kenan Keven, Gokhan Nergizoglu, Sehsuvar Erturk, Sule Sengul
BACKGROUND/AIMS: Hypertension and its complications are major public health issues worldwide due to their association with high cardiovascular morbidity and mortality. Despite significant progress in health, the prevalence of hypertension is increasing. Ambulatory blood pressure monitoring (ABPM) is becoming increasingly important for the management of hypertension. In this study, we aimed to investigate the clinical and laboratory correlates of ambulatory blood pressure (ABP) phenotypes at a tertiary care hospital in Turkey...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29763709/fenofibrate-effects-on-carotid-artery-intima-media-thickness-in-adults-with-type-2-diabetes-mellitus-a-field-substudy
#8
Jason A Harmer, Anthony C Keech, Anne-Sophie Veillard, Michael R Skilton, Gerald F Watts, David S Celermajer
AIM: Dyslipidemia in type 2 diabetes contributes to an increased risk of cardiovascular disease. Fenofibrate, a lipid-regulating peroxisome proliferator-activated receptor-α (PPARα) agonist, has been shown to reduce vascular complications in adults with type 2 diabetes. The mechanisms for such benefit, however, are not yet well understood. We examined the effects of fenofibrate on carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in adults with type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29755036/pregnancy-related-risk-factors-are-associated-with-a-significant-burden-of-treated-hypertension-within-10-years-of-delivery-findings-from-a-population-based-norwegian-cohort
#9
Grace M Egeland, Svetlana Skurtveit, Anne Cathrine Staff, Geir Egil Eide, Anne-Kjersti Daltveit, Kari Klungsøyr, Lill Trogstad, Per M Magnus, Anne Lise Brantsæter, Margaretha Haugen
BACKGROUND: The association between pregnancy complications and women's later cardiovascular disease has, primarily, been evaluated in studies lacking information on important covariates. This report evaluates the prospective associations between pregnancy-related risk factors (preeclampsia/eclampsia, gestational hypertension, pregestational and gestational diabetes mellitus, preterm delivery, and fetal growth restriction) and pharmacologically treated hypertension within 10 years after pregnancy, while adjusting for a wide range of covariates...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29753422/prevalence-of-diabetes-and-dyslipidemia-in-hypertensive-patients-in-the-area-of-blida-algeria
#10
A Bachir Cherif, S Bennouar, A Bouamra, A Taleb, F Hamida, M Temmar, M T Bouafia
PURPOSE: Diabetes mellitus (DM) and lipid disorders (LD) in hypertensive patients are associated with an increased risk of cardiovascular complications requiring follow-up and more aggressive therapeutic strategies. The main objective of this study was to describe the prevalence of DM and LD in adult hypertensive patients followed in specialized consultation of hypertension in the region of Blida (North Algeria) during the period from January 2013 to June 2017. MATERIALS AND METHODS: We included 3268 hypertensive patients (1453 men and 1815 women), mean age of 58...
May 9, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29750228/hypertension-among-newly-diagnosed-diabetic-patients-at-mulago-national-referral-hospital-in-uganda-a-cross-sectional-study
#11
Martin Muddu, Edrisa Mutebi, Isaac Ssinabulya, Samuel Kizito, Charles Kiiza Mondo
BACKGROUND: The prevalence of hypertension in patients with diabetes is approximately two-fold higher than in age-matched subjects without the disease and, conversely, individuals with hypertension are at increased risk of developing diabetes compared with normotensive persons. Up to 75% of cases of cardiovascular disease (CVD) in patients with diabetes are attributed to hypertension. Diabetics who have hypertension are more likely to develop complications and die, and appropriate blood pressure control in these individuals reduces the risk...
April 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29745919/type-2-diabetes-mellitus-and-cerebral-small-vessel-disease-case-report
#12
S Sopromadze
Patients with type 2 diabetes mellitus have an increased risk of cardiovascular (CV) morbidity and mortality. Recently, brain has been described also as a target organ for diabetic microvascular complications. Cerebral small vessel disease (SVD) may cause lacunar infarcts and cognitive dysfunction. In our case a brain MRI scan showed distinct lesions, which are mainly caused and seen by long lasting diabetes and hypertension.
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29745916/fournier-s-gangrene-a-rare-complication-of-diabetes-mellitus-case-report
#13
Sh Muharremi
The presented case reports on 54-years old patient with T2 Diabetes mellitus who, due to hypoglycemic episodes on Insulin therapy, was treated with oral anti-hyperglycemic medications. Patient was on hemodialysis due to the stage 5 chronic kidney failure and had various comorbid conditions: arterial hypertension, history of acute myocardial infarction, dilative cardiomyopathy, amaurosis and peripheral neuropathy. Besides his complicated medical history, patient developed an early stage of Fournier's gangrene...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29730785/may-the-force-be-with-you-why-resistance-training-is-essential-for-subjects-with-type-2-diabetes-mellitus-without-complications
#14
REVIEW
Roberto Codella, Marta Ialacqua, Ileana Terruzzi, Livio Luzi
Physical activity, together with diet and pharmacological therapy, represents one of the three cornerstones in type 2 diabetes mellitus treatment and care. The therapeutic appeal of regular physical activity stems from: (i) its non-pharmacological nature; (ii) its beneficial effects on the metabolic risk factors associated with diabetes complications; (iii) its low costs. Evidence accumulated in the last years suggests that aerobic training-endurance training-constitutes a safe modality of intervention, achievable, and effective in diabetes treatment, whenever it is not limited by comorbidities...
May 5, 2018: Endocrine
https://www.readbyqxmd.com/read/29728993/the-crosstalk-of-gut-microbiota-and-chronic-kidney-disease-role-of-inflammation-proteinuria-hypertension-and-diabetes-mellitus
#15
REVIEW
Mehmet Kanbay, Emine M Onal, Baris Afsar, Tuncay Dagel, Aslihan Yerlikaya, Adrian Covic, Nosratola D Vaziri
Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD...
May 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29726706/-i-hibiscus-sabdariffa-i-roselle-polyphenol-rich-extract-averts-cardiac-functional-and-structural-abnormalities-in-type-1-diabetic-rats
#16
Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Norsyahida Mohd Fauzi, Siti Balkis Budin
Diabetes mellitus is often associated with cardiac functional and structural alteration, an initial event leading to cardiovascular complications. <i>Hibiscus sabdariffa</i> or roselle has been widely proven as an antioxidant and recently has incited research interest for its potential in treating cardiovascular disease. Therefore, this study aimed to determine the cardioprotective effects of <i>H. sabdariffa </i>(roselle) polyphenol-rich extract (HPE) in type-1 induced diabetic rats...
May 4, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29721015/a-comparative-assessment-of-cardiovascular-autonomic-reflex-testing-and-cardiac-123-i-metaiodobenzylguanidine-imaging-in-patients-with-type-1-diabetes-mellitus-without-complications-or-cardiovascular-risk-factors
#17
Triantafyllos Didangelos, Efstratios Moralidis, Eleni Karlafti, Konstantinos Tziomalos, Charalambos Margaritidis, Zisis Kontoninas, Ioannis Stergiou, Maria Boulbou, Marianthi Papagianni, Emmanouel Papanastasiou, Apostolos I Hatzitolios
Aim: To compare the cardiovascular autonomic reflex tests (CARTs) with cardiac sympathetic innervation imaging with 123 I-metaiodobenzylguanidine (MIBG) in patients with type 1 diabetes mellitus (T1DM). Patients and Methods: Forty-nine patients (29 males, mean age 36 ± 10 years, mean T1DM duration 19 ± 6 years) without cardiovascular risk factors were prospectively enrolled. Participants were evaluated for autonomic dysfunction by assessing the mean circular resultant (MCR), Valsalva maneuver (Vals), postural index (PI), and orthostatic hypotension (OH)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29720539/its-reticulated-the-liver-at-the-heart-of-atherosclerosis
#18
Prabhakara R Nagareddy, Sunil K Noothi, Michelle Christine Flynn, Andrew Murphy
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing the risk of myocardial ischemia (MI), stroke, or death due to cardiovascular disease (CVD). However, antiplatelet therapies lose their efficacy in people with diabetes mellitus (DM), increasing the risk of future atherothrombotic events. The molecular mechanisms that promote platelet hyperactivity remain unclear but could be due to glycation-induced conformational changes of platelet membranes resulting in impaired aspirin entry, or less-efficient acetylation/compensatory increase in COX-2 expression in newborn platelets...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29716870/role-of-leptin-and-dyslipidemia-in-chronic-kidney-disease
#19
Sabeela Noor, Faiza Alam, Syeda Sadia Fatima, Mahnur Khan, Rehana Rehman
Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular complications and plasma leptin level is elevated in cardio renal syndrome. We wanted to explore leptin levels in patients with different stages of CKD and find its association with risk of cardiovascular disease. This cross-sectional study was conducted in Nephrology Department of Jinnah Post Graduate Medical Centre (JPMC) from January 2014 to September 2014. Group I comprised of controls (GFR=116±8.3, n = 44) acquired from general population, CKD patients were grouped as II, III and IV respectively with GFR; 85...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29709706/argirein-alleviates-vascular-endothelial-insulin-resistance-through-suppressing-the-activation-of-nox4-dependent-o-2-production-in-diabetic-rats
#20
Qing Li, Jie Su, Shi-Jie Jin, Wei Wei, Xiao-Dong Cong, Xiao-Xue Li, Ming Xu
BACKGROUND: Insulin resistance in endothelial cells contributes to the development of cardiovascular disease in type 2 diabetes mellitus (T2DM). Therefore, there are great potential clinical implications in developing pharmacological interventions targeting endothelial insulin resistance. Our previous studies indicated that argirein which was developed by combining rhein with L-arginine by a hydrogen bond, could substantially relieved stress related exacerbation of cardiac failure and alleviated cardiac dysfunction in T2DM, which was associated with suppressing NADPH oxidase activity...
April 27, 2018: Free Radical Biology & Medicine
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