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https://www.readbyqxmd.com/read/29055248/simultaneous-quantification-of-direct-oral-anticoagulants-currently-used-in-anticoagulation-therapy
#1
Kathrin I Foerster, Andrea Huppertz, Oliver J Müller, Timolaos Rizos, Lisa Tilemann, Walter E Haefeli, Jürgen Burhenne
Direct oral anticoagulants (DOACs) are among the most effective options to prevent serious thromboembolic events in patients with atrial fibrillation. Coagulation assays are used to assess DOAC activity, but lack the possibility to quantify drugs with concurrent pharmacodynamic effect. We developed a selective multi-drug assay to analyze apixaban, betrixaban, dabigatran, edoxaban, edoxaban M4, and rivaroxaban with ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) in plasma fulfilling all requirements of the FDA und EMA guidelines for bioanalytical method validation...
October 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#2
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055108/semi-quantitative-analysis-of-tramadol-dextromethorphan-and-metabolites-in-decomposed-skeletal-tissues-by-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-qtof-ms
#3
H M Cornthwaite, L Labine, J H Watterson
The use of filtration/pass-through extraction (FPTE) and ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-qTOF-MS) to detect tramadol (TRAM), dextromethorphan (DXM) and metabolites from skeletal remains is described. Rats (n=5) received 50 mg/kg tramadol and were euthanized by CO2 asphyxiation approximately 30 min post-dose. Rats (n=4) received 75 mg/kg dextromethorphan and were euthanized by CO2 asphyxiation approximately 45 min post-dose. Remains decomposed to skeleton outdoors and vertebral bones were collected...
October 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29055065/simultaneous-determination-of-usnic-diffractaic-evernic-and-barbatic-acids-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-quadrupole-exactive-orbitrap-mass-spectrometry-and-its-application-to-pharmacokinetic-studies
#4
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang
Usnea longissima Ach. (Usnea) has been used in pharmaceuticals, food, cosmetics. Evernic acid (EA), barbatic acid (BA), diffractaic acid (DA), and usnic acid (UA) are the most typical ingredients in U. longissima and exert a wide variety of biological functions. The study aim to develop a sensitive method for simultaneous analysis of EA, BA, DA, and UA in rat plasma and applied to pharmacokinetic studies after consumption of UA and ethanol extract from U. longissima (UE). The samples were separated on BEH C18 column by gradient elution with 0...
October 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29054905/ultra-wide-imaging-in-a-case-of-retinal-vasculitis-with-macular-star
#5
Abhishek Sheemar, Brijesh Takkar, Shreyas Temkar, Pradeep Venkatesh
No abstract text is available yet for this article.
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054616/green-synthesized-nanoclusters-of-ultra-small-zero-valent-iron-nanoparticles-as-a-novel-dye-removing-material
#6
Alireza Ebrahiminezhad, Saeed Taghizadeh, Younes Ghasemi, Aydin Berenjian
Iron based nanoparticles have gained much attention in recent years due to their unique physicochemical properties especially in the environmental remediation practices. There has been an increasing demand for new sustainable techniques for production of these nanoparticles. In the present work, a novel iron nanostructure was successfully fabricated by a facile and green approach using the aqueous extract of Mediterranean cypress (Cupressus sempervirens). In fact, nanoclusters of highly reactive ultra-small (~1...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054369/exosome-is-a-mechanism-of-intercellular-drug-transfer-application-of-quantitative-pharmacology
#7
Jin Wang, Bertrand Z Yeung, Minjian Cui, Cody J Peer, Ze Lu, William D Figg, M Guillaume Wientjes, Sukyung Woo, Jessie L-S Au
PURPOSE: Exosomes are small membrane vesicles (30-100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and quantified the contribution of exosomes to intercellular drug transfer and pharmacodynamics. METHODS: Human cancer cells (breast MCF7, breast-to-lung metastatic LM2, ovarian A2780 and OVCAR4) were treated with paclitaxel (PTX, 2-1000nM) or doxorubicin (DOX, 20-1000nM) for 24-48h...
October 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29054150/pesticides-in-essential-oils-occurrence-and-concentration-in-organic-and-conventional-orange-essential-oils-from-eleven-geographical-origins
#8
Yoann Fillâtre, François-Xavier Gray, Céline Roy
In this paper is described for the first time the application of both gas chromatography-tandem mass spectrometry (GC-MS/MS) and ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-QTOF-MS) to the determination of 75 priority pesticides in orange essential oils (EOs). The sample preparation consisted in a 10-fold dilution of orange EO followed by a direct injection for GC-MS/MS technique and a freeze-out step in the case of UPLC-QTOF-MS analysis. The analytical methods were validated using the SANCO criteria and gave reporting limits (RLs) of 10 μg L(-1), 25 μg L(-1), 50 μg L(-1) and 100 μg L(-1) for 57, 13, 4 and 1 pesticides, respectively...
November 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29054145/simple-high-efficiency-detection-of-microcystins-and-nodularin-r-in-water-by-fluorescence-polarization-immunoassay
#9
Huiyan Zhang, Shupeng Yang, Ross C Beier, Natalia V Beloglazova, Hongtao Lei, Xiulan Sun, Yuebin Ke, Suxia Zhang, Zhanhui Wang
This manuscript describes the development of a sensitive, fast and easily-performed fluorescence polarization immunoassay (FPIA) for detection of microcystins (MCs) and nodularin-R (NOD) in water. MCs and NOD, the most widespread cyanobacterial toxin are hepatotoxins and tumor promoters, and their acute exposure may result in severe health problems in animals and humans. The fluorescein-based tracers were synthesized, and for the first time preparative high performance liquid chromatography (HPLC) was employed for their purification...
November 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29054142/elemental-hair-analysis-a-review-of-procedures-and-applications
#10
REVIEW
D Pozebon, G L Scheffler, V L Dressler
Although exogenous contamination and unreliable reference values have limited the utility of scalp hair as a biomarker of chemical elements exposure, its use in toxicological, clinical, environmental and forensic investigations is growing and becoming more extensive. Therefore, hair elemental analysis is reviewed in the current manuscript which spans articles published in the last 10 years. It starts with a general discussion of history, morphology and possible techniques for elemental analysis, where inductively coupled plasma-mass spectrometry (ICP-MS) is clearly highlighted since this technique is leading quantitative ultra-trace elemental analysis...
November 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29053892/ultra-fast-molecular-rotors-within-porous-organic-cages
#11
Ashlea R Hughes, Nick J Brownbill, Rachel C Lalek, Michael E Briggs, Anna G Slater, Andrew I Cooper, Frederic Blanc
Using variable temperature 2H static NMR spectra and 13C spin-lattice relaxation times (T1), we show that two different porous organic cages with tubular architectures are ultra-fast molecular rotors. The central para-phenylene rings that frame the 'windows' to the cage voids display very rapid rotational rates of the order of 1.2-8 x106 Hz at 230 K with low activation energy barriers in the 12-18 kJ mol-1 range. These cages act as hosts to iodine guest molecules, which dramatically slows down the rotational rates of the phenylene groups (5- 10 x104 Hz at 230 K), demonstrating potential use in applications that require molecular capture and release...
October 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29053798/in-vivo-characterization-of-cortical-and-white-matter-neuroaxonal-pathology-in-early-multiple-sclerosis
#12
Tobias Granberg, Qiuyun Fan, Constantina Andrada Treaba, Russell Ouellette, Elena Herranz, Gabriel Mangeat, Céline Louapre, Julien Cohen-Adad, Eric C Klawiter, Jacob A Sloane, Caterina Mainero
Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis; however, its underlying pathophysiological mechanisms, including its link to inflammatory demyelination and temporal occurrence in the disease course are still unknown. We used ultra-high field (7 T), ultra-high gradient strength diffusion and T1/T2-weighted myelin-sensitive magnetic resonance imaging to characterize microstructural changes in myelin and neuroaxonal integrity in the cortex and white matter in early stage multiple sclerosis, their distribution in lesional and normal-appearing tissue, and their correlations with neurological disability...
October 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053618/the-application-of-ultra-high-performance-liquid-chromatography-coupled-with-a-ltq-orbitrap-mass-technique-to-reveal-the-dynamic-accumulation-of-secondary-metabolites-in-licorice-under-aba-stress
#13
Da Li, Guojie Xu, Guangxi Ren, Yufeng Sun, Ying Huang, Chunsheng Liu
The traditional medicine licorice is the most widely consumed herbal product in the world. Although much research work on studying the changes in the active compounds of licorice has been reported, there are still many areas, such as the dynamic accumulation of secondary metabolites in licorice, that need to be further studied. In this study, the secondary metabolites from licorice under two different methods of stress were investigated by ultra-high-performance liquid chromatography coupled with hybrid linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS)...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053595/magnetic-properties-of-fibonacci-modulated-fe-au-multilayer-metamaterials
#14
Tomomi Suwa, Satoshi Tomita, Nobuyoshi Hosoito, Hisao Yanagi
Herein we experimentally study magnetic multilayer metamaterials with broken translational symmetry. Epitaxially-grown iron-gold (Fe-Au) multilayers modulated using Fibonacci sequence-referred to as magnetic inverse Fibonacci-modulated multilayers (IFMs)-are prepared using ultra-high-vacuum vapor deposition. Experimental results of in-situ reflection high-energy electron diffraction, magnetization curves, and ferromagnetic resonance demonstrate that the epitaxially-grown Fe-Au IFMs have quasi-isotropic magnetization, in contrast to the in-plane magnetization easy axis in the periodic multilayers...
October 20, 2017: Materials
https://www.readbyqxmd.com/read/29053537/thermal-ultra-short-photodynamic-therapy-heating-fibroblasts-during-sub-30-minute-incubation-of-5-aminolevulinic-acid-increases-photodynamic-therapy-induced-cell-death
#15
Eugene Koo, Evan Austin, Andrew Mamalis, Jared Jagdeo
BACKGROUND: Actinic keratoses (AKs) prevalence was estimated at 39.5 million Americans in 2004, and the cost to treat AKs that year was approximately 1 billion dollars. Photodynamic therapy (PDT) is an FDA-approved therapy for the treatment of AK. Recent studies have focused on reducing PDT treatment time while maintaining efficacy. OBJECTIVE: To investigate the use of thermal modulation to improve the efficacy of ultra short aminolevulinic acid (ALA) incubation PDT...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29053250/hierarchically-designed-3d-flower-like-composite-nanostructures-as-an-ultra-stable-reproducible-and-sensitive-sers-substrate
#16
Sezin Yüksel, Mario Ziegler, Sebastian Goerke, Uwe Huebner, Karina Weber, Peter Schaaf, Hans-Georg Meyer, Dana Cialla-May, Jürgen Popp
Surface enhanced Raman spectroscopy (SERS) is an attractive tool in analytical sciences due to its high specificity and sensitivity. Since the SERS active substrates are only available as 2D arrays, the fabrication of 3D nanostructures allows for an increased number of hot spots in the focus volume, thus further amplifying the SERS signal. Although a great number of fabrication strategies for powerful SERS substrates exist, the generation of 3D nanostructures with high complexity and periodicity is still challenging...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29053249/holistic-lipidomics-of-the-human-gut-phenotype-using-validated-ultra-high-performance-liquid-chromatography-coupled-to-hybrid-orbitrap-mass-spectrometry
#17
Lieven Van Meulebroek, Ellen De Paepe, Vicky Vercruysse, Beata Pomian, Simon Bos, Bruno Lapauw, Lynn Vanhaecke
As lipids are assigned a plethora of biological functions, it is evident that a dysregulated lipid metabolism signifies a key element in many pathological conditions. With this rationale, this study presents a validated lipidomics platform to map the fecal lipidome, which integrates unique information about the host-gut microbiome interactions, gastrointestinal functionality, and dietary pattern. This particular method accomplished coverage across all eight lipid categories; the fatty acyls, glycerolipids, phosphoglycerolipids, polyketides, prenols, saccharolipids, sphingolipids, and sterols...
October 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29052978/natural-biowaste-cocoons-derived-granular-activated-carbon-coated-zno-nanorods-a-simple-route-to-synthesis-core-shell-structure-and-their-highly-enhanced-uv-and-hydrogen-sensing-properties
#18
Adhimoorthy Saravanan, Bohr-Ran Huang, Deepa Kathiravan, Adhimoorthy Prasannan
Granular activated carbon (GAC) materials were prepared via simple gas activation of silk-worm cocoon, and coated on ZnO nanorods (ZNRs) by facile hydrothermal method. The present combination of GAC and ZNRs show a core-shell structure (where the GAC is coated on the surface of ZNRs), is exposed by the systematic material analysis. The as-prepared samples were then fabricated as dual-functional sensors and, most fascinatingly, the as-fabricated core shell structure exhibits better UV and H2 sensing properties than those of as-fabricated ZNRs and GAC...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29052514/five-fraction-sbrt-for-ultra-central-nsclc-in-field-recurrences-following-high-dose-conventional-radiation
#19
Michael C Repka, Nima Aghdam, Shaan K Kataria, Lloyd Campbell, Simeng Suy, Sean P Collins, Eric Anderson, Jonathan W Lischalk, Brian T Collins
PURPOSE/OBJECTIVE: Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body radiation therapy (SBRT) is a promising modality to achieve reasonable local control, although toxicity remains a concern. MATERIALS/METHODS: Patients previously treated with high-dose CF-EBRT (≥59.4 Gy, ≤3 Gy/fraction) for non-metastatic NSCLC who underwent salvage SBRT for localized ultra-central in-field recurrence were included in this analysis...
October 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29052403/-serum-metabonomics-in-mice-infected-with-mycoplasma-pneumoniae-by-uplc-q-tof-ms
#20
Wen-Feng Wei, Yan-Tao Chu, Ye Liu, Jin-Hai Huo, Wei-Ming Wang
Ultra high performance liquid chromatography coupled with tandem quadrupole time of flight mass spectrometry(UPLC-Q-TOF-MS) was applied to metabonomics study in BALB/c mice infected with mycoplasma pneumoniae(MP) to analyze the changes in serum endogenous metabolites, identify potential biomarkers associated with mycoplasma pneumoniae pneumonia(MPP), analyze the metabolic pathway and explore the pathogenic mechanism of MPP. The BALB/c mice were inoculated with MP by repeated intranasal infectious routes to establish MPP models, and the results of the lung tissue biopsy, IgM and mycoplasma nucleic acid content determination showed that the models of MP in BALB/c mice were successfully established...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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