Alice Nodari, Ilaria Scambi, Daniele Peroni, Elisa Calabria, Donatella Benati, Silvia Mannucci, Marcello Manfredi, Andrea Frontini, Silvia Visonà, Andrea Bozzato, Andrea Sbarbati, Federico Schena, Emilio Marengo, Mauro Krampera, Mirco Galiè
Dysregulated immunity and widespread metabolic dysfunctions are the most relevant hallmarks of the passing of time over the course of adult life, and their combination at midlife is strongly related to increased vulnerability to diseases; however, the causal connection between them remains largely unclear. By combining multi-omics and functional analyses of adipose-derived stromal cells established from young (1 month) and midlife (12 months) mice, we show that an increase in expression of interferon regulatory factor 7 (IRF7) during adult life drives major metabolic changes, which include impaired mitochondrial function, altered amino acid biogenesis and reduced expression of genes involved in branched-chain amino acid (BCAA) degradation...
June 1, 2021: Journal of Cell Science