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https://www.readbyqxmd.com/read/29341893/targeting-bdnf-modulation-by-plant-glycosides-as-a-novel-therapeutic-strategy-in-the-treatment-of-depression
#1
REVIEW
Haroon Khan, Surriya Amin, Seema Patel
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of this review is to focus on the antidepressant effects of glycosides in preclinical studies, with an emphasis on the possible mechanisms. The literature search revealed that only a few phytoglycosides have been evaluated for their relevance in depression alleviation...
January 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29341340/bias-from-restricting-to-live-births-when-estimating-effects-of-prescription-drug-use-on-pregnancy-complications-a-simulation
#2
Elizabeth A Suarez, Suzanne N Landi, Mitchell C Conover, Michele Jonsson Funk
PURPOSE: Administrative claim databases are increasingly being used to study the safety of medication exposures during pregnancy. These studies are restricted to live births due to a reliance on algorithms for estimating gestational age that are based on codes associated with live delivery. Conditioning on live birth may induce selection bias when studying the effect of a drug on a pregnancy complication if fetal death is a competing risk for the complication or is caused by the complication...
January 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29340866/-in-silico-study-of-the-binding-of-two-novel-antagonists-to-the-nociceptin-receptor
#3
Stefano Della Longa, Alessandro Arcovito
Antagonists of the nociceptin receptor (NOP) are raising interest for their possible clinical use as antidepressant drugs. Recently, the structure of NOP in complex with some piperidine-based antagonists has been revealed by X-ray crystallography. In this study, a multi-flexible docking (MF-docking) procedure, i.e. docking to multiple receptor conformations extracted by preliminary molecular dynamics trajectories, together with hybrid quantum mechanics/molecular mechanics (QM/MM) simulations have been carried out to provide the binding mode of two novel NOP antagonists, one of them selective (BTRX-246040, formerly named LY-2940094) and one non selective (AT-076), i...
January 16, 2018: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29340802/longitudinal-trajectories-of-antidepressant-use-in-pregnancy-and-the-postnatal-period
#4
Gretchen Bandoli, Grace M Kuo, Renu Sugathan, Christina D Chambers, Matthieu Rolland, Kristin Palmsten
Studies of antidepressant safety in pregnancy typically do not address complex patterns of use throughout pregnancy. We performed longitudinal trajectory modeling to describe patterns of antidepressant use in the first 32 weeks of pregnancy, and test whether these trajectories are associated with a reduction in birth weight or gestational age at delivery. Our study included 166 pregnant women with deliveries between 2011 and 2015 who were prescribed an antidepressant between 91 days prior to last menstrual period and 32 weeks of gestation...
January 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29340272/migraine-preventive-prescription-patterns-by-physician-specialty-in-ambulatory-care-settings-in-the-united-states
#5
Hiroko Takaki, Daisuke Onozuka, Akihito Hagihara
Many adults with migraine who require preventive therapy are often not prescribed the proper medications. The most likely reason is that primary care physicians are unacquainted with preventive medications for migraine. The present study assessed the migraine-preventive prescription patterns in office visits using data from the National Ambulatory Medical Care Survey from 2006 to 2009 in the United States. Patients who were 18 years or older and diagnosed with migraine were included in the analysis. In accordance with the recommendations of the headache guidelines, we included beta-blockers, antidepressants, triptans for short-term prevention of menstrual migraine, and other triptans for acute treatment...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29339968/analysis-of-questions-about-use-of-drugs-in-breastfeeding-to-norwegian-drug-information-centres
#6
Jan Anker Jahnsen, Sofia Frost Widnes, Jan Schjøtt
Background: Health professionals may advise women to either stop breastfeeding or drug treatment due to restrictive advice in drug monographs. Regional medicines information and pharmacovigilance centres in Norway (RELIS) provide free and industry-independent answers to questions about drugs and breastfeeding documented in a full-text, searchable database (RELIS database). We used the RELIS database to describe which health care practitioners sought information about medication safety in lactation, most common drugs involved, advice provided and which resources were used to provide the advice...
2018: International Breastfeeding Journal
https://www.readbyqxmd.com/read/29339292/selective-hcn1-block-as-a-strategy-to-control-oxaliplatin-induced-neuropathy
#7
F Resta, L Micheli, A Laurino, V Spinelli, T Mello, L Sartiani, L Di Cesare Mannelli, E Cerbai, C Ghelardini, M N Romanelli, G Mannaioni, A Masi
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is the most frequent adverse effect of pharmacological cancer treatments. The occurrence of neuropathy prevents the administration of fully-effective drug regimen, affects negatively the quality of life of patients, and may lead to therapy discontinuation. CIPN is currently treated with anticonvulsants, antidepressants, opioids and non-opioid analgesics, all of which are flawed by insufficient anti-hyperalgesic efficacy or addictive potential. Understandably, developing new drugs targeting CIPN-specific pathogenic mechanisms would dramatically improve efficacy and tolerability of anti-neuropathic therapies...
January 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29338677/vitamin-b-6-and-depressive-symptomatology-over-time-in-older-latino-adults
#8
Sandra P Arévalo, Tammy M Scott, Luis M Falcón, Katherine L Tucker
BACKGROUND: Low vitamin B-6 status has been linked to depressive symptomatology. We examined the longitudinal association of vitamin B-6 status with depressive symptomatology across 3-time points over ∼5-7 years in a cohort of older Hispanic adults. METHODS: We used two-level hierarchical linear regression models for continuous outcomes. Vitamin B-6 status was associated with depressive symptomatology across these time points. RESULTS: Plasma pyridoxyl-5-phosphate (PLP) concentration, a time-varying predictor, was significantly associated with depressive symptomatology...
January 16, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29338537/antidepressant-prescriptions-and-mental-health-nurses-an-observational-study-in-dutch-general-practice-from-2011-to-2015
#9
Tessa Magnée, Derek P de Beurs, Francois G Schellevis, Peter F Verhaak
PURPOSE: The purpose of this study was to investigate developments in antidepressant prescriptions by Dutch general practitioners, alongside the national introduction of mental health nurses. Antidepressant prescriptions are very common in general practice, but are often not in line with recommendations. The recent introduction of mental health nurses may have decreased antidepressant prescriptions, as general practitioners (GPs) have greater potential to offer psychological treatment as a first choice option instead of medication...
January 17, 2018: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29337859/effects-of-pharmacists-interventions-on-inappropriate-drug-use-and-drug-related-readmissions-in-people-with-dementia-a-secondary-analysis-of-a-randomized-controlled-trial
#10
Maria Gustafsson, Maria Sjölander, Bettina Pfister, Jörn Schneede, Hugo Lövheim
Age-associated physiological changes and extensive drug treatment including use of potentially inappropriate medications (PIMs) pose a significant risk of drug-drug interactions and adverse drug events among elderly people with dementia. This study aimed at analysing the effects of clinical pharmacists' interventions on use of PIMs, risk of emergency department visits, and time to institutionalization. Furthermore, a descriptive analysis was conducted of circumstances associated with drug-related readmissions...
January 16, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29337584/is-antidepressant-use-associated-with-difficulty-identifying-feelings-a-brief-report
#11
Jani Kajanoja, Noora M Scheinin, Max Karukivi, Linnea Karlsson, Hasse Karlsson
Studies on the subjective effects of antidepressants suggest that they may not only improve depressed mood, but as an adverse effect also cause "emotional blunting." This phenomenon is poorly understood and little studied. The aim of this study was to examine the association of serotonergic antidepressant use and subjective emotional awareness. Emotional awareness was assessed using the Difficulty Identifying Feelings subscale from the 20-Item Toronto Alexithymia Scale. Fifty-seven individuals on antidepressant medication and 441 controls were compared...
January 15, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29337001/antidepressant-treatment-duration-in-pediatric-depressive-and-anxiety-disorders-how-long-is-long-enough
#12
Elizabeth E Hathaway, John T Walkup, Jeffrey R Strawn
Anxiety and depressive disorders are common in the pediatric primary care setting, and respond to both psychotherapeutic and psychopharmacologic treatment. However, there are limited data regarding the optimal treatment duration. This article systematically reviews guidelines and clinical trial data related to antidepressant treatment duration in pediatric patients with depressive and anxiety disorders. The extant literature suggests 9-12 months of antidepressant treatment for youth with major depressive disorder...
January 11, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29336714/urinary-retention-and-medication-utilization-on-a-palliative-care-unit-a-retrospective-observational-study
#13
T Graham Bergstra, Iris Gutmanis, Janette Byrne, Cathy Faulds, Patricia Whitfield, Sarah McCallum, Joshua Shadd
Urinary retention is a common problem at end-of-life that may be a result of medications used to control other symptoms. To determine whether use of retention-causing drugs was associated with catheterization for urinary retention among palliative care unit (PCU) patients, the authors reviewed charts of 91 consecutively admitted patients to a hospital-based PCU. Utilization of eight classes of retention-causing medications (opioids, antidopaminergics, benzodiazepines, anticholinergics, antidepressants, calcium channel antagonists, nonsteroidal anti-inflammatory drugs [NSAIDs], and H1 histamine antagonists) was compared between those catheterized for urinary retention (n = 34) and those never catheterized (n = 31)...
January 16, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29335402/a-partially-open-inward-facing-intermediate-conformation-of-leut-is-associated-with-na-release-and-substrate-transport
#14
Daniel S Terry, Rachel A Kolster, Matthias Quick, Michael V LeVine, George Khelashvili, Zhou Zhou, Harel Weinstein, Jonathan A Javitch, Scott C Blanchard
Neurotransmitter:sodium symporters (NSS), targets of antidepressants and psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na+)-coupled transport. Substrate and Na+ are thought to be transported from the extracellular to intracellular space through an alternating access mechanism by coordinated conformational rearrangements in the symporter that alternately expose the binding sites to each side of the membrane. However, the mechanism by which the binding of ligands coordinates conformational changes occurring on opposite sides of the membrane is not well understood...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29335038/what-is-the-prevalence-of-untreated-depression-and-death-ideation-in-older-people-data-from-the-irish-longitudinal-study-on-aging
#15
Robert Briggs, Katy Tobin, Rose Anne Kenny, Sean P Kennelly
OBJECTIVE: Late life depression (LLD) confers significant morbidity and mortality but is well recognized that it often goes undetected or untreated. The objective of this study is to quantify the burden of untreated depression and death ideation (DI) at a population level. DESIGN: Cross-sectional study ascertaining the prevalence of, and factors associated with, untreated depression and DI. SETTING: This study, embedded within the Irish Longitudinal Study on Ageing, involves over 7,000 community-dwelling people aged ≥50 years...
January 16, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29334877/utilization-of-mental-health-services-by-children-displaced-by-hurricane-katrina
#16
Troy Quast, Sean Gregory, Eric A Storch
OBJECTIVE: This study examined changes in utilization of mental health services after Hurricane Katrina among children with preexisting conditions who were displaced from their homes in Louisiana disaster counties and resettled in Texas. METHODS: A retrospective analysis was performed on Medicaid claims data for 101,950 children from 2004 to 2006. Pre-post changes in utilization of mental health services by the displaced children and three control groups were compared...
January 16, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29334874/a-comparison-of-collaborative-care-outcomes-in-two-health-care-systems-va-clinics-and-federally-qualified-health-centers
#17
Kathleen M Grubbs, John C Fortney, Jeffrey Pyne, Dinesh Mittal, John Ray, Teresa J Hudson
OBJECTIVE: Collaborative care for depression results in symptom reduction when compared with usual care. No studies have systematically compared collaborative care outcomes between veterans treated at Veterans Affairs (VA) clinics and civilians treated at publicly funded federally qualified health centers (FQHCs) after controlling for demographic and clinical characteristics. METHODS: Data from two randomized controlled trials that used a similar collaborative care intervention for depression were combined to conduct post hoc analyses (N=759)...
January 16, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29334809/accidental-pharmacological-poisonings-in-young-children-population-based-study-in-three-settings
#18
Jane C Bell, Jason P Bentley, Catriona Downie, Rose Cairns, Nicholas A Buckley, Annette Katelaris, Sallie-Anne Pearson, Natasha Nassar
INTRODUCTION: Pharmacological poisonings in young children are avoidable. Previous studies report calls to poisons centres, presentations to emergency departments (ED) or hospital admissions. There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals. METHODS: A population-based study in New South Wales, Australia, of PIC calls, ED presentations and hospital admissions for accidental pharmacological poisoning in children aged <5 years, 2007-2013...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29334636/impact-of-demographic-factors-on-the-antidepressant-effect-a-patient-level-data-analysis-from-depression-trials-submitted-to-the-pharmaceuticals-and-medical-devices-agency-in-japan
#19
Tetsuo Nakabayashi, Ayako Hara, Hirofumi Minami
A substantial and variable placebo response can cause unreliable findings in clinical trials designed to demonstrate the efficacy of antidepressants, and the high rate of failed trials represents a major obstacle in the development of new drugs for major depressive disorder (MDD). However, the influence of demographic and symptom factors on the antidepressant effect remains to be established. The purpose of this study was to estimate the magnitude of this influence. A patient-level meta-analysis of data from double-blind, randomized, placebo-controlled trials involving the use of antidepressants for adults with MDD was performed...
January 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29334322/plasma-brain-derived-neurotrophic-factor-pbdnf-and-executive-dysfunctions-in-patients-with-major-depressive-disorder
#20
Stefanie Wagner, Sarah Kayser, Jan Engelmann, Konrad F Schlicht, Nadine Dreimüller, Oliver Tüscher, Florian Müller-Dahlhaus, Dieter F Braus, André Tadić, Alexandra Neyazi, Helge Frieling, Klaus Lieb
OBJECTIVES: Executive dysfunctions are frequently seen in patients with Major Depressive Disorder (MDD) and normalize in many cases during effective antidepressant therapy. This study investigated whether a normalization of executive dysfunctions during antidepressant treatment correlates with or can be predicted by clinical parameters or levels of brain-derived neurotrophic factor (BDNF). METHODS: In 110 MDD patients with executive dysfunctions (percentile < 16), executive functions and plasma BDNF levels were analysed at baseline, day 14 and 56 of an antidepressant treatment...
January 15, 2018: World Journal of Biological Psychiatry
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