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Giovanni A Fava, Giada Benasi, Marcella Lucente, Emanuela Offidani, Fiammetta Cosci, Jenny Guidi
BACKGROUND: Serotonin-noradrenaline reuptake inhibitors (SNRI) are widely used in medical practice. Their discontinuation has been associated with a wide range of symptoms. The aim of this paper is to identify the occurrence, frequency, and features of withdrawal symptoms after SNRI discontinuation. METHODS: PRISMA guidelines were followed to conduct a systematic review. Electronic databases included PubMed, the Cochrane Library, Web of Science, and MEDLINE from the inception of each database to June 2017...
July 17, 2018: Psychotherapy and Psychosomatics
Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, Rodolfo Baldinotti, Mariana G Fronza, Renata Balaguez, Diego Alves, César Augusto Brüning, Lucielli Savegnago
Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antinociceptive activities in animal models, without showing acute toxicity. In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis...
July 14, 2018: Brain Research Bulletin
Agnieszka Ewa Laudy
Non-antibiotic medicinal products consist of drugs with diverse activity against bacteria. Many non-antibiotics demonstrate direct anti-bacterial activity against Gram-positive cocci. The activity observed against Gram-negative rods is much lower and non-antibiotics primarily from the following groups: non-steroidal anti-inflammatory drugs, cardiovascular and antidepressant medicinal products demonstrate this activity. It has been shown that the low activity of some non-antibiotics or the absence of activity against Gram-negative rods is related, among other things, to the extrusion of these compounds from bacterial cells by multi-drug resistance efflux pumps...
June 30, 2018: Polish Journal of Microbiology
Tong-Hua Yang, Yun-Bao Ma, Chang-An Geng, De-Xiu Yan, Xiao-Yan Huang, Tian-Ze Li, Xue-Mei Zhang, Ji-Jun Chen
Depression is associated with high mortality and morbidity rates worldwide. By our random screening, it was first revealed that 23 magnolol derivatives were synthesized followed by in vitro and in vivo evaluation of their antidepressive potential. Compound 7c was found to be the most promising compound, with EC50 values of 396.5 and 383.0 μM agitating on MT1 and MT2 receptors, respectively. Additionally, we carried out in vivo experiments to confirm the efficacy and safety of compound 7c; the compound was found to be orally bioavailable and highly effective, leading to a significant reduction of immobility time in a mouse model of depression (forced swimming test and tail suspension test); the acting mechanism was explored by determining its effect on the levels of monoamine neurotransmitters and their metabolites in different mice brain regions; the acute toxicity study showed that the 50% lethal dose (LD50) of 7c was higher than 2000 mg/kg, p...
July 10, 2018: European Journal of Medicinal Chemistry
Rai Khalid Farooq, Arnaud Tanti, Samia Ainouche, Sébastien Roger, Catherine Belzung, Vincent Camus
A polymorphism in the P2RX7 gene that encodes for the P2X7 ionotropic ATP-gated receptor (P2X7R) protein has been shown to be associated with an increased risk for developing depressive illnesses. However, the role of P2X7R in depression is still unclear. To better understand the role of P2X7R and its subsequent impact on microglial activation, we compared the effect of the P2X7R antagonist Brilliant Blue G (BBG) with that of fluoxetine in an unpredictable chronic mild stress (UCMS) model of depression in mice...
July 10, 2018: Psychoneuroendocrinology
Han Qu, Ruixue Ma, Bin Wang, Yizhe Zhang, Lina Yin, Gang Yu, Shubo Deng, Jun Huang, Yujue Wang
In this study, we investigated the enantioselective environmental behaviors of the chiral antidepressant venlafaxine (VFX) in lab-scale aquatic ecosystems in the presence of microplastics (MPs). To determine the bioaccumulation, distribution, and metabolism as well as the effects of MPs on aquatic ecosystems, water-sediment, water-Lemna.minor (L.minor), water-Misgurnus.anguillicaudatus (M.anguillicaudatus), and water-sediment-L.minor-M.anguillicaudatus ecosystems were set up and exposed to venlafaxine and two levels of microplastics over a 90-day period...
July 8, 2018: Journal of Hazardous Materials
Qin Xiang Ng, Alex Yu Sen Soh, Donovan Yutong Lim, Wee-Song Yeo
WHAT IS KNOWN AND OBJECTIVE: Irritable bowel syndrome (IBS) is a complex and chronic, relapsing gastrointestinal condition that affects more than 10% of the population worldwide. There is a pressing need for new therapeutic strategies in the management of IBS. Increasing research has shed light on the modulatory functions of melatonin on pain, local inflammation and motility in the gastrointestinal tract. However, melatonin's effects are limited by its extensive first-pass metabolism and short half-life...
July 16, 2018: Journal of Clinical Pharmacy and Therapeutics
Natalie Bareis, Trisha A Sando, Briana Mezuk, Steven A Cohen
OBJECTIVE: Psychotropic medications (e.g., antidepressants, anxiolytics, and neuroleptics) are increasingly prescribed with two or more taken concurrently (polypharmacy), and have been associated with an increased risk of falling. The aim of this study was to examine the association between psychotropic medication use and balance impairment using an objective balance measure. METHODS: We derived data from participants aged 40 years and older in the US National Health and Nutrition Examination Survey (1999/00-2003/04) who completed the Modified Clinical Trial of Sensory Interaction and Balance and indicated current medications (n = 3090)...
July 16, 2018: CNS Drugs
Parineeta Thapa, Pramote Euasobhon
Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain...
July 2018: Korean Journal of Pain
Okan Arihan, Samiye Ciftci Yabanoglu, Gulberk Ucar, Neslihan Dikmenoglu Falkmarken
BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs), antidepressants commonly used in cardiovascular diseases (CVDs), inhibit the re-uptake of serotonin not only into neurons but also into platelets. Hence they increase the level of serotonin in plasma. OBJECTIVE: This study was aimed to clarify the effects of two selected SSRIs on plasma serotonin level, hemorheological parameters (hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity) and selected oxidative stress markers (MDA, GSH, GSSG levels in plasma and erythrocytes)...
July 11, 2018: Clinical Hemorheology and Microcirculation
Caroline Park, Elisa Brietzke, Joshua D Rosenblat, Natalie Musial, Hannah Zuckerman, Renee-Marie Ragguett, Zihang Pan, Carola Rong, Dominika Fus, Roger S McIntyre
During the past decade, there has been renewed interest in the relationship between brain-based disorders, the gut microbiota, and the possible beneficial effects of probiotics. Emerging evidence suggests that modifying the composition of the gut microbiota via probiotic supplementation may be a viable adjuvant treatment option for individuals with major depressive disorder. Convergent evidence indicates that persistent low-grade inflammatory activation is associated with the diagnosis of MDD as well as the severity of depressive symptoms and probability of treatment response...
July 13, 2018: Brain, Behavior, and Immunity
Marya S Sabir, Mark R Haussler, Sanchita Mallick, Ichiro Kaneko, Daniel A Lucas, Carol A Haussler, G Kerr Whitfield, Peter W Jurutka
Background: Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We reported previously that 1,25D induces expression of tryptophan hydroxylase-2 (TPH2), the initial and rate-limiting enzyme in the biosynthetic pathway to 5-HT, in cultured rat serotonergic neuronal cells...
2018: Genes & Nutrition
Nathan J Smischney, Emily M Pollard, Asha U Nookala, Oludare O Olatoye
BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications. As the use of antidepressant medications has increased, the incidence of perioperative serotonin syndrome has transitioned from a rare diagnosis to one that should be considered as a differential diagnosis for any patient displaying signs of neuroexcitation. CASE REPORT A 70-year-old man (ASA 2) with a history of vestibular migraines (treated with venlafaxine), gastroesophageal reflux disease, and benign prostatic hyperplasia presented to our institution for photoselective vaporization of the prostate...
July 16, 2018: American Journal of Case Reports
Michael Yang, Danielle F Loeb, Andrew J Sprowell, Katy E Trinkley
Registries are fundamental to the success of population health initiatives to improve care and outcomes for patients, including those with depression. The purpose of this article is to describe the design and clinical implementation of a depression registry as part of a collaborative care for depression intervention at 2 large academic outpatient internal medicine practices. The primary objective of the registry was to identify and track patients with depression and monitor antidepressant therapy. Secondary objectives of the registry were to assist in addressing pay-for-performance and value-based reimbursement metrics for depression screening and remission...
July 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
Gabriel Hancu, Monica Budău, Daniela Lucia Muntean, Laszlo Gagyi, Aura Rusu
Chirality is a primordial subject in modern drug research as well as in pharmaceutical industry and development. Almost all second-generation modern antidepressants are chiral substances; however in therapy some are used as racemic mixtures while others as pure enantiomers. The development of enantioseparation methods of chiral antidepressants and their metabolites is one of the keys towards understanding their enantioselective drug action. For this purpose, efficient and reliable analytical methods are needed, and capillary electrophoresis proved to be an interesting and advantageous alternative to the more frequently used chromatographic techniques...
July 13, 2018: Biomedical Chromatography: BMC
Elizabeth Wall-Wieler, Leslie L Roos, Marni Brownell, Nathan C Nickel, Dan Chateau, Kendra Nixon
Objectives This study examines whether mothers involved with child protection services (CPS) at the birth of their first child had higher rates of postpartum depression and anxiety. Methods A retrospective cohort of mothers whose first child was born in Manitoba, Canada between April 1, 1995 and March 31, 2015 is used. Postpartum depression and anxiety among mothers whose first child was placed in care at birth (n = 776) was compared with mothers who received services from CPS (but whose children were not placed in care) (n = 4,270), and a 3:1 matched group of mothers who had no involvement with CPS in the first year of their firstborn's life (n = 2,328)...
July 13, 2018: Maternal and Child Health Journal
Carmen Nanclares, Isabel Gameiro-Ros, Iago Mendez-Lopez, Carmen Martinez-Ramirez, Juan F Padin-Nogueira, Ines Colmena, Andres M Baraibar, Luis Gandia Juan, Antonio Garcia Garcia
The inhibition of nicotinic acetylcholine receptors (nAChRs) has been proposed as a potential strategy to develop new antidepressant drugs. This is based in the observation that antidepressants that selectively block noradrenaline (NA) or serotonin (5-HT) reuptake, also inhibit nAChRs. Dual antidepressants blocking both NA and 5-HT reuptake were proposed to shorten the delay in exerting their clinical effects; whether duloxetine, prototype of dual antidepressants, also block nAChRs is unknown. Here we explored this question in bovine chromaffin cells (BCCs) that express native α3, α5 and α7 nAChR and in cell lines expressing human α7, α3β4 or α4β2 nAChRs...
July 13, 2018: Journal of Pharmacology and Experimental Therapeutics
Mauricio P Cunha, Francis L Pazini, Vicente Lieberknecht, Ana Lúcia S Rodrigues
Creatine has been shown to play a significant role in the pathophysiology and treatment of major depressive disorder (MDD) in preclinical and clinical studies. However, the biological mechanisms underlying its antidepressant effect is still not fully elucidated. This study investigated the effect of creatine (p.o.) administered for 21 days in the behavior of mice submitted to tail suspension test (TST), a predictive test of antidepressant activity. Creatine reduced the immobility time in the TST (1-10 mg/kg), without affecting locomotor activity, a finding consistent with an antidepressant profile...
July 6, 2018: Journal of Psychiatric Research
G Fond, A Bourbon, P Auquier, J-A Micoulaud-Franchi, C Lançon, L Boyer
Medical student wellness has emerged as an important issue in medical education. OBJECTIVE: To evaluate the gender influence on psychiatric and/or psychological follow-up, psychotropic and illicit drug consumption, addictive behaviors, quality of life and motives for consumption in a large multicentric national sample of medical students. METHODS: Medical students of the 35 French Medicine faculties were recruited through mailing lists and social networks between December 2016 and May 2017 and fulfilled Internet anonymized questionnaires...
July 6, 2018: Journal of Affective Disorders
Alexey P Sarapultsev, Pavel M Vassiliev, Petr A Sarapultsev, Oleg N Chupakhin, Laura R Ianalieva, Larisa P Sidorova
This review focuses on the biological action of the compounds from the group of substituted 1,3,4-thiadiazines on stress response and myocardial infarction. The aim of this review is to propose the possible mechanisms of action of 1,3,4-thiadiazines and offer prospectives in the development of new derivatives as therapeutic agents. It is known, that compounds that have biological effects similar to those used as antidepressants can down-regulate the secretion of proinflammatory cytokines, up-regulate the release of anti-inflammatory ones and affect cell recruitment, which allows them to be considered immunomodulators as well...
July 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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