keyword
MENU ▼
Read by QxMD icon Read
search

Branched-chain amino acid

keyword
https://www.readbyqxmd.com/read/28721839/branched-chain-amino-acid-meat-intake-and-risk-of-type-2-diabetes-in-the-women-s-health-initiative
#1
Masoud Isanejad, Andrea Z LaCroix, Cynthia A Thomson, Lesley Tinker, Joseph C Larson, Qibin Qi, Lihong Qi, Rhonda M Cooper-DeHoff, Lawrence S Phillips, Ross L Prentice, Jeannette M Beasley
Knowledge regarding association of dietary branched-chain amino acid (BCAA) and type 2 diabetes (T2D), and the contribution of BCAA from meat to the risk of T2D are scarce. We evaluated associations between dietary BCAA intake, meat intake, interaction between BCAA and meat intake and risk of T2D. Data analyses were performed for 74 155 participants aged 50-79 years at baseline from the Women's Health Initiative for up to 15 years of follow-up. We excluded from analysis participants with treated T2D, and factors potentially associated with T2D or missing covariate data...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28719620/endurance-performance-and-energy-metabolism-during-exercise-in-mice-with-a-muscle-specific-defect-in-the-control-of-branched-chain-amino-acid-catabolism
#2
Minjun Xu, Yasuyuki Kitaura, Takuya Ishikawa, Yoshihiro Kadota, Chihaya Terai, Daichi Shindo, Takashi Morioka, Miki Ota, Yukako Morishita, Kengo Ishihara, Yoshiharu Shimomura
It is known that the catabolism of branched-chain amino acids (BCAAs) in skeletal muscle is suppressed under normal and sedentary conditions but is promoted by exercise. BCAA catabolism in muscle tissues is regulated by the branched-chain α-keto acid (BCKA) dehydrogenase complex, which is inactivated by phosphorylation by BCKA dehydrogenase kinase (BDK). In the present study, we used muscle-specific BDK deficient mice (BDK-mKO mice) to examine the effect of uncontrolled BCAA catabolism on endurance exercise performance and skeletal muscle energy metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28717254/the-molecular-mechanisms-of-monascus-purpureus-m9-responses-to-blue-light-based-on-the-transcriptome-analysis
#3
Di Chen, Mianhua Chen, Shufen Wu, Zhenjing Li, Hua Yang, Changlu Wang
Light is an important environmental factor that regulates various physiological processes of fungi. To thoroughly study the responses of Monascus to blue light, transcriptome sequencing was performed on mRNAs isolated from samples of Monascus purpureus M9 cultured under three conditions: darkness (D); exposure to blue light for 15 min/d (B15); and exposure to blue light for 60 min/d over 8 days (B60). The number of differentially expressed genes between the three pairs of samples-B15 vs D, B60 vs B15, and B60 vs D-was 1167, 1172, and 220, respectively...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717019/3-hydroxyisobutyryl-coa-hydrolase-involved-in-isoleucine-catabolism-regulates-triacylglycerol-accumulation-in-phaeodactylum-tricornutum
#4
Yufang Pan, Juan Yang, Yangmin Gong, Xiaolong Li, Hanhua Hu
Since methylmalonyl-CoA epimerase appears to be absent in the majority of photosynthetic organisms, including diatoms, (S)-methylmalonyl-CoA, the intermediate of isoleucine (Ile) catabolism, cannot be metabolized to (R)-methylmalonyl-CoA then to succinyl-CoA. In this study, propionyl-CoA carboxylase (PCC) RNAi silenced strains and 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) overexpression strains were constructed to elucidate the Ile degradation pathway and its influence on lipid accumulation in Phaeodactylum tricornutum based on growth, neutral lipid content and metabolite profile analysis...
September 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28713581/short-term-elevation-in-dietary-protein-intake-does-not-worsen-insulin-resistance-or-lipids-in-older-adults-with-metabolic-syndrome-a-randomized-controlled-trial
#5
Il-Young Kim, Scott E Schutzler, Gohar Azhar, Robert R Wolfe, Arny A Ferrando, Robert H Coker
BACKGROUND: There is a great deal of controversy as to whether higher protein intake improves or worsens insulin sensitivity in humans. The purpose of the study was to determine the influence of a short-term elevation in dietary protein on hepatic and peripheral insulin sensitivity in twelve older subjects (51-70 yrs) with metabolic syndrome. METHODS: Individuals were randomly assigned to one of the dietary groups: recommended protein intake (RPI, 10% of daily calorie intake) or elevated protein intake (EPI, 20% of daily calorie intake) for 4 weeks...
2017: BMC Nutrition
https://www.readbyqxmd.com/read/28706002/micrornas-that-contribute-to-coordinating-the-immune-response-in-drosophila-melanogaster
#6
Magda L Atilano, Marcus Glittenberg, Annabel Monteiro, Richard Copley, Petros Ligoxygakis
Small noncoding RNAs called microRNAs (miRNAs) have emerged as post-transcriptional regulators of gene expression related to host defences. Here, we have used Drosophila melanogaster to explore the contribution of individual or clusters of miRNAs in countering systemic C. albicans infection. From a total of 72 tested, we identify six miRNAs allelic mutant backgrounds that modulate the survival response to infection and ability to control pathogen number. These mutants also exhibit dysregulation of the Toll pathway target transcripts Drosomycin (Drs) and Immune-Induced Molecule 1 (IM1)...
July 13, 2017: Genetics
https://www.readbyqxmd.com/read/28705827/3-hydroxyisobutyrate-dehydrogenase-is-involved-in-valine-and-isoleucine-degradation-in-a-thaliana
#7
Peter Schertl, Lennart Danne, Hans-Peter Braun
In plants, amino acid catabolism is especially relevant at metabolic stress situations, e.g. limited carbohydrate availability during extended darkness. Under these conditions, amino acids are used as alternative substrates for respiration. Complete oxidation of the branched chain amino acids (BCAAs) Leucine, Isoleucine and Valine in the mitochondria efficiently allows formation of ATP by oxidative phosphorylation. However, the metabolic pathways for BCAA breakdown are largely unknown so far in plants. A systematic search for Arabidopsis genes encoding proteins resembling enzymes involved in BCAA catabolism in animals, fungi and bacteria as well as proteomic analyses of mitochondrial fractions from Arabidopsis allowed identification of a putative 3-Hydroxyisobutyrate dehydrogenase, AtHDH1 (At4g20930), involved in Valine degradation...
July 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28701315/effect-of-endurance-training-and-branched-chain-amino-acids-on-the-signaling-for-muscle-protein-synthesis-in-ckd-model-rats-fed-a-low-protein-diet
#8
Takuya Yoshida, Sachika Kakizawa, Yuri Totsuka, Miho Sugimoto, Shinji Miura, Hiromichi Kumagai
A low-protein diet (LPD) protects against the progression of renal injury in patients with chronic kidney disease (CKD). However, LPD may accelerate muscle wasting in these patients. Both exercise and branched chain amino acids (BCAA) are known to increase muscle protein synthesis by activating the mammalian target of rapamycin (mTOR) pathway. The aim of this study is to investigate whether endurance exercise and BCAA play a role for increasing muscle protein synthesis in LPD-fed CKD (5/6 nephrectomized) rats...
July 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28699638/bcat1-controls-metabolic-reprogramming-in-activated-human-macrophages-and-is-associated-with-inflammatory-diseases
#9
Adonia E Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K Srivastava, Hong A Vu, Danilo Cucchi, Stephen P McAdoo, Elitsa A Ananieva, Claudio Mauro, Jacques Behmoaras
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show that BCAT1 is the predominant BCAT isoform in human primary macrophages. We identify ERG240 as a leucine analogue that blocks BCAT1 activity. Selective inhibition of BCAT1 activity results in decreased oxygen consumption and glycolysis. This decrease is associated with reduced IRG1 levels and itaconate synthesis, suggesting involvement of BCAA catabolism through the IRG1/itaconate axis within the tricarboxylic acid cycle in activated macrophages...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28698587/a-novel-dual-eigen-analysis-of-mouse-multi-tissues-expression-profiles-unveils-new-perspectives-into-type-2-diabetes
#10
Lei M Li, Xiuxiu Liu, Lin Wang, Yong Wang, Xiuqin Liu, Xue Tian, Fuzhou Gong, Li Shen, Xiao-Ding Peng
Type 2 diabetes (T2D) is a complex and polygenic disease yet in need of a complete picture of its development mechanisms. To better understand the mechanisms, we examined gene expression profiles of multi-tissues from outbred mice fed with a high-fat diet (HFD) or regular chow at weeks 1, 9, and 18. To analyze such complex data, we proposed a novel dual eigen-analysis, in which the sample- and gene-eigenvectors correspond respectively to the macro- and micro-biology information. The dual eigen-analysis identified the HFD eigenvectors as well as the endogenous eigenvectors for each tissue...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696987/nutritional-supplements-for-the-treatment-and-prevention-of-sports-related-concussion-evidence-still-lacking
#11
Thomas H Trojian, David H Wang, John J Leddy
Concussions are common neurologic events that affect many athletes. Very little has been studied on the treatment of concussions with supplements and medications. The U.S. Food and Drug Administration (FDA) reminds us that no supplement has been proven to treat concussions. Many animal studies show that supplements have potential for improving the effects of a brain injury but none have been shown to be of consistent benefit in human studies. Animal studies on severe traumatic brain injury (TBI) may not therefore be applicable transfer to sports-related concussions (SRC)...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28696790/competitive-inhibition-of-amino-acid-transport-in-human-preovulatory-ovarian-follicles
#12
Maciej Jóźwik, Marcin Jóźwik, Anna Justyna Milewska, Frederick C Battaglia, Michał Jóźwik
To date we have yet to examine whether amino acid (AA) transport in human ovarian follicles is affected by competitive inhibition. In contrast, transplacental transfer of AAs in late-gestation sheep is characterized by reciprocal competition. This phenomenon has been described by algebraic equations of umbilical uptake of AAs based on maternal arterial concentrations. In the present translational study at a university teaching hospital, we verified whether these equations apply to the transport of AAs from blood to follicular fluid (FF) in human preovulatory follicles...
July 11, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28695065/-13-c-based-proteinogenic-amino-acid-paa-and-metabolic-flux-ratio-analysis-of-lactococcus-lactis-reveals-changes-in-pentose-phosphate-pp-pathway-in-response-to-agitation-and-temperature-related-stresses
#13
Kamalrul Azlan Azizan, Habtom W Ressom, Eduardo R Mendoza, Syarul Nataqain Baharum
Lactococcus lactis subsp. cremoris MG1363 is an important starter culture for dairy fermentation. During industrial fermentations, L. lactis is constantly exposed to stresses that affect the growth and performance of the bacterium. Although the response of L. lactis to several stresses has been described, the adaptation mechanisms at the level of in vivo fluxes have seldom been described. To gain insights into cellular metabolism, (13)C metabolic flux analysis and gas chromatography mass spectrometry (GC-MS) were used to measure the flux ratios of active pathways in the central metabolism of L...
2017: PeerJ
https://www.readbyqxmd.com/read/28690380/identification-of-inhibitors-against-%C3%AE-isopropylmalate-synthase-of-mycobacterium-tuberculosis-using-docking-mm-pbsa-hybrid-approach
#14
Preeti Pandey, Andrew M Lynn, Pradipta Bandyopadhyay
α-Isopropylmalate Synthase (α-IPMS) encoded by leuA in Mycobacterium tuberculosis (M.tb) is involved in the leucine biosynthesis pathway and is extremely critical for the synthesis of branched-chain amino acids (leucine, isoleucine and valine). α-IPMS activity is required not only for the proliferation of M.tb but is also indispensable for its survival during the latent phase of infection. It is absent in humans and is widely regarded as one of the validated drug targets against Tuberculosis (TB). Despite its essentiality, any study on designing of potential chemical inhibitors against α-IPMS has not been reported so far...
2017: Bioinformation
https://www.readbyqxmd.com/read/28686938/quantitative-proteomic-analyses-of-the-microbial-degradation-of-estrone-under-various-background-nitrogen-and-carbon-conditions
#15
Zhe Du, Yinguang Chen, Xu Li
Microbial degradation of estrogenic compounds can be affected by the nitrogen source and background carbon in the environment. However, the underlying mechanisms are not well understood. The objective of this study was to elucidate the molecular mechanisms of estrone (E1) biodegradation at the protein level under various background nitrogen (nitrate or ammonium) and carbon conditions (no background carbon, acetic acid, or humic acid as background carbon) by a newly isolated bacterial strain. The E1 degrading bacterial strain, Hydrogenophaga atypica ZD1, was isolated from river sediments and its proteome was characterized under various experimental conditions using quantitative proteomics...
June 26, 2017: Water Research
https://www.readbyqxmd.com/read/28681360/intact-protein-analysis-at-21-tesla-and-x-ray-crystallography-define-structural-differences-in-single-amino-acid-variants-of-human-mitochondrial-branched-chain-amino-acid-aminotransferase-2-bcat2
#16
Lissa C Anderson, Maria Håkansson, Björn Walse, Carol L Nilsson
Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogenomic screen of patient-derived glioblastoma (GBM) tumor materials, we identified a sequence variant of human mitochondrial branched-chain amino acid aminotransferase 2 as a putative factor of resistance of GBM to standard-of-care-treatments...
July 5, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28672086/circulating-branched-chain-amino-acids-in-children-with-obstructive-sleep-apnea
#17
Antonia Barceló, Josep Miquel Bauça, José Antonio Peña-Zarza, Daniel Morell-Garcia, Aina Yáñez, Gerardo Pérez, Javier Piérola, Nuria Toledo, Mónica de la Peña
INTRODUCTION: The effects of obstructive sleep apnea (OSA) on the metabolic system are not well understood, especially in children. Recent studies have provided evidence of the modulation of insulin action by branched-chain amino acids (BCAAs) and suggested novel mechanistic relationships between glucose and amino acid metabolic pathways. We hypothesized that plasma BCAA levels may serve as biomarkers of insulin resistance and metabolic dysfunction in children with OSA. METHODS: A polysomnography was conducted for the diagnosis of OSA in 90 snoring children, in a tertiary hospital...
July 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28671274/hepatocytes-of-wistar-and-sprague-dawley-rats-differ-significantly-in-their-central-metabolism
#18
Richa Garg, Elmar Heinzle, Fozia Noor
Wistar and Sprague-Dawley (SD) rats are the most commonly used experimental rats. They have similar genetic background and are therefore, not discriminated in practical research. In this study, we compared metabolic profiles of Wistar and SD rat hepatocytes from middle (6 months) and old (23 months) age groups. Specific uptake and production rates of amino acids, glucose, lactate and urea showed clear differences between Wistar and SD rats as shown by principle component analysis (PCA). SD rat hepatocytes showed higher uptake rates of various essential and non-essential amino acids, particularly in early culture phases (0-12 h) compared to later phases (12-24 h)...
July 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28668976/abscisic-acid-regulated-protein-degradation-causes-osmotic-stress-induced-accumulation-of-branched-chain-amino-acids-in-arabidopsis-thaliana
#19
Tengfang Huang, Georg Jander
Whereas proline accumulates through de novo biosynthesis in plants subjected to osmotic stress, leucine, isoleucine, and valine accumulation in drought-stressed Arabidopsis thaliana is caused by abscisic acid-regulated protein degradation. In response to several kinds of abiotic stress, plants greatly increase their accumulation of free amino acids. Although stress-induced proline increases have been studied the most extensively, the fold-increase of other amino acids, in particular branched-chain amino acids (BCAAs; leucine, isoleucine, and valine), is often higher than that of proline...
July 1, 2017: Planta
https://www.readbyqxmd.com/read/28668481/life-extending-dietary-restriction-and-ovariectomy-each-increase-leucine-oxidation-and-alter-leucine-allocation-in-grasshoppers
#20
John D Hatle, Ayesha Awan, Justin Nicholas, Ryan Koch, Julie R Vokrri, Marshall D McCue, Caroline M Williams, Goggy Davidowitz, Daniel A Hahn
Reduced reproduction and dietary restriction each extend lifespan in many animal models, but possible contributions of nutrient oxidation and allocation are largely unknown. Ovariectomy and eating 70% of ad libitum-feeding each extend lifespan in lubber grasshoppers. When feeding levels between the two groups are matched, ovariectomy increases fat and protein storage while dietary restriction reduces fat storage. Because of these disparities in nutrient investment, metabolism may differ between these two life-extending treatments...
June 28, 2017: Experimental Gerontology
keyword
keyword
49998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"